15 results match your criteria Expert Review of Dermatology[Journal]

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The role of dynamic infrared imaging in melanoma diagnosis.

Authors:
Cila Herman

Expert Rev Dermatol 2013 Apr;8(2):177-184

Department of Mechanical Engineering, The Johns Hopkins University, Baltimore, MD, USA.

Melanoma incidence and the lifetime risk are increasing at an alarming rate in the United States and worldwide. In order to improve survival rates, the goal is to detect melanoma at an early stage of the disease. Accurate, sensitive and reliable quantitative diagnostic tools can reduce the number of unnecessary biopsies, the associated morbidity as well as the costs of care in addition to improving survival rates. Read More

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http://www.tandfonline.com/doi/full/10.1586/edm.13.15
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http://dx.doi.org/10.1586/edm.13.15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670775PMC
April 2013
7 Reads

Aldehyde dehydrogenase isozymes: markers of cancer stem cells in human melanoma.

Expert Rev Dermatol 2013;8(2):111-113

Department of Dermatology, University of Colorado Denver, Mail Stop 8127, 12801 E 17th Ave., Rm 4124, Aurora, CO 80045, USA and Charles C Gates Center for Regenerative Medicine & Stem Cell Biology, University of Colorado Denver, Aurora, CO 80045, USA and Denver Veterans Affairs Medical Center, Denver, CO, USA.

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http://dx.doi.org/10.1586/edm.13.2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749134PMC
January 2013
6 Reads

Neuro-immune-endocrine functions of the skin: an overview.

Expert Rev Dermatol 2013 ;8(6):581-583

Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, 930 Madison Avenue, 5th Floor, Memphis, TN, USA and Department of Medicine, Center for Adult Cancer Research, University of Tennessee Health Science Center, Memphis, TN, USA, Tel.: +1 901 448 3741.

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http://dx.doi.org/10.1586/17469872.2013.856690DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3938165PMC
January 2013
12 Reads

Human skin organ culture for assessment of chemically induced skin damage.

Authors:
James Varani

Expert Rev Dermatol 2012 Jun;7(3):295-303

Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA, Tel.: +1 734 615 0298,

The move away from animal models for skin safety testing is inevitable. It is a question of when, not if. As skin safety studies move away from traditional animal-based approaches, a number of replacement technologies are becoming available. Read More

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http://dx.doi.org/10.1586/edm.12.24DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792533PMC
June 2012
2 Reads

Radiation therapy in the management of Merkel cell carcinoma: current perspectives.

Expert Rev Dermatol 2011 Aug;6(4):395-404

Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

Merkel cell carcinoma (MCC) is a rare cutaneous neuroendocrine neoplasm with a propensity for metastatic spread. When managing MCC, surgical excision is often the initial treatment. As MCC is generally radiosensitive, many institutions include adjuvant radiation therapy (RT) in their standard treatment protocols. Read More

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http://dx.doi.org/10.1586/edm.11.40DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3615640PMC
August 2011
5 Reads

Update on the regulation of mammalian melanocyte function and skin pigmentation.

Expert Rev Dermatol 2011 Feb;6(1):97-108

Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

Melanogenesis is the unique process of producing pigmented biopolymers that are sequestered within melanosomes, which provides color to the skin, hair and eyes of animals and, in the case of human skin, also protects the underlying tissues from UV damage. We review the current understanding of melanogenesis, focusing on factors important to the biochemistry of pigment synthesis, the biogenesis of melanosomes, signaling pathways and factors that regulate melanogenesis, intramelanosomal pH, transport and transfer of melanosomes, and pigmentary disorders related to the dysfunction of melanosome-related proteins. Although it has been known for some time that many of the factors that affect melanogenesis are derived from keratinocytes, fibroblasts, endothelial cells, hormones, inflammatory cells and nerves, a number of new factors that are involved in that regulation have recently been reported, such as factors that regulate melanosome pH and ion transport. Read More

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http://dx.doi.org/10.1586/edm.10.70DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3093193PMC
February 2011
27 Reads

Neutrophils and natural killer T cells as negative regulators of wound healing.

Expert Rev Dermatol 2011 Feb;6(1):5-8

The Burn and Shock Trauma Institute and Program in Cell Biology, Neurobiology, and Anatomy and Immunology and Aging Program and Stritch School of Medicine, Loyola University Medical Center, 2160 South First Avenue, Maywood, IL 60153, USA.

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http://www.tandfonline.com/doi/full/10.1586/edm.10.66
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http://dx.doi.org/10.1586/edm.10.66DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3063646PMC
February 2011
6 Reads

Staphylococcus colonization of the skin and antimicrobial peptides.

Authors:
Michael Otto

Expert Rev Dermatol 2010 Apr;5(2):183-195

National Institute of Allergy and Infectious Diseases, NIH, 9000 Rockville Pike, Building 33 1W10, Bethesda, MD 20892, USA, Tel.: +1 301 443 5209.

Staphylococci are the most abundant skin-colonizing bacteria and the most important causes of nosocomial infections and community-associated skin infections. Molecular determinants of staphylococcal skin colonization include surface polymers and proteins that promote adhesion and aggregation, and a wide variety of mechanisms to evade acquired and innate host defenses. Antimicrobial peptides (AMPs) likely play a central role in providing immunity to bacterial colonization on human epithelia. Read More

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http://www.tandfonline.com/doi/full/10.1586/edm.10.6
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http://dx.doi.org/10.1586/edm.10.6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2867359PMC
April 2010
5 Reads

Genetics and genomics of melanoma.

Expert Rev Dermatol 2009 Apr;4(2):131

Dana-Farber Cancer Institute, Department of Medical Oncology, 44 Binney Street, Boston, MA 02215, USA, Tel.: +1 617 258 8614, ,

The rapidly increasing incidence of melanoma, coupled with its highly aggressive metastatic nature, is of urgent concern. In order to design rational therapies, it is of critical importance to identify the genetic determinants that drive melanoma formation and progression. To date, signaling cascades emanating from the EGF receptor, c-MET and other receptors are known to be altered in melanoma. Read More

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http://dx.doi.org/10.1586/edm.09.2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2771951PMC
April 2009
9 Reads

Nodal as a biomarker for melanoma progression and a new therapeutic target for clinical intervention.

Expert Rev Dermatol 2009 ;4(1):67-78

Children's Memorial Research Center, 2300 Children's Plaza, Box 222, Chicago, IL 60614, USA Tel.: +1 773 755 6327

Nodal, an embryonic morphogen belonging to the TGF-β superfamily, is an important regulator of embryonic stem cell fate. We have recently demonstrated that Nodal is expressed significantly in aggressive melanoma. Surprisingly, expression of the Nodal coreceptor, Cripto-1, was detected in only a small fraction of the melanoma tumor cell population, indicating a primary role for Cripto-1-independent signaling of Nodal in melanoma. Read More

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http://dx.doi.org/10.1586/17469872.4.1.67DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2682534PMC
January 2009
42 Reads

Current concepts of metastasis in melanoma.

Expert Rev Dermatol 2008 Oct;3(5):569-585

Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, 930 Madison Avenue, Memphis, TN 38163, USA, Tel.: +1 901 448 6300, ,

The main cause of death in melanoma patients is widespread metastases. Staging of melanoma is based on the primary tumor thickness, ulceration, lymph node and distant metastases. Metastases develop in regional lymph nodes, as satellite or in-transit lesions, or in distant organs. Read More

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http://dx.doi.org/10.1586/17469872.3.5.569DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2601641PMC
October 2008
4 Reads

Novel acquisitions on the immunoprotective roles of the EGF receptor in the skin.

Expert Rev Dermatol 2008 Oct;3(5):525-527

Laboratory of Tissue Engineering and Cutaneous Physiopathology, Istituto Dermopatico dell'Immacolata, IRCCS, via Monti di Creta 104, 00167 Roma, Italy Tel.: +39 066 646 4718

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http://dx.doi.org/10.1586/17469872.3.5.525DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2600505PMC
October 2008
2 Reads

Ribosomal stress, p53 activation and the tanning response.

Expert Rev Dermatol 2008 Dec;3(6):649-656

Oncogenomics Laboratory, Queensland Institute of Medical Research, 300 Herston Rd, Herston, 4029, Qld, Australia.

Melanocytes (MC) sit along the epidermal basal layer, largely quiescent except for constitutive melanin production. They are usually only activated after sun exposure. The recent paper by McGowan et al. Read More

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http://dx.doi.org/10.1586/17469872.3.6.649DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3427653PMC
December 2008
4 Reads

Mechanism of UV-related carcinogenesis and its contribution to nevi/melanoma.

Expert Rev Dermatol 2007 ;2(4):451-469

Department of Medical Biology, Nicolaus Copernicus University, Torun, Poland, Tel: (4856)611-4776, , E-mail:

Melanoma consists 4-5 % of all skin cancers, but it contributes to 71-80 % of skin cancers deaths. UV light affects cell and tissue homeostasis due to its damaging effects on DNA integrity and modification of expression of a plethora of genes. DNA repair systems protect cells from UV-induced lesions. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2564815PMC
January 2007
38 Reads

GENE PROFILING: IMPLICATIONS IN DERMATOLOGY.

Expert Rev Dermatol 2007;2(6):763-768

Hospital for Special Surgery, Tissue Repair Lab, Tissue Engineering, Regeneration and Repair Program, 535 E 70 Street, New York, NY 10021 USA; Department of Dermatology, Weill Medical College of the Cornell University, 1300 York Avenue, New York, NY 10021, USA, 212 774-7160.

DNA microarrays are capable of following the level of expression of, virtually, all genes in a human tissue. This has been employed to determine the aberrant gene expression profiles in many skin diseases, including ultraviolet light damage, inflammatory processes and cancers. Because of its accessibility, skin also served as one of the initial targets of basic research using DNA microarrays. Read More

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http://dx.doi.org/10.1586/17469872.2.6.763DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4982393PMC
January 2007
4 Reads
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