128,230 results match your criteria Expert Review of Clinical Immunology[Journal]
Eur J Cardiothorac Surg 2019 Jan;55(1):163-171
Department of Cardiovascular Surgery, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Int J Drug Policy 2018 Dec 11;64:30-33. Epub 2018 Dec 11.
British Columbia Centre on Substance Use, 400-1045 Howe Street, Vancouver, BC, V6Z 2A9, Canada; Department of Medicine, University of British Columbia, St. Paul's Hospital, 608-1081 Burrard Street, Vancouver, BC, V6Z 1Y6, Canada; School of Medicine, University College Dublin, Health Sciences Centre, Belfield, Dublin 4, Ireland. Electronic address:
Background: Opioid agonist therapy (OAT) is a first-line treatment for opioid use disorder (OUD); however, the efficacy and role of urine drug screening (UDS) in OAT has received little research attention. Prior evidence suggests that UDS frequency reflects philosophy and practice context rather than differences in patient characteristics or clinical need. Therefore, we reviewed the literature on the effect of and recommendations for the frequency of UDS on health outcomes for persons with OUD who receive OAT. Read More
Sci Total Environ 2018 Dec 3;657:517-534. Epub 2018 Dec 3.
Department of Biology & CESAM, University of Aveiro, Campus de Santiago, 3810-193 Aveiro, Portugal.
Global initiatives have been increasingly focusing on mainstreaming the values of biodiversity and ecosystem services into decision-making at all levels. Due to the accelerated rate at which biodiversity is declining and its consequences for the functioning of ecosystems and subsequently, the services they provide, there is need to develop comprehensive assessments of the services and the benefits nature delivers to society. Based on expert evaluation, we identified relevant flow linkages in the supply-side of the socio-ecological system, i. Read More
PLoS Negl Trop Dis 2018 Dec 14;12(12):e0006938. Epub 2018 Dec 14.
Faculty of Medicine, National Autonomous University of Mexico, Mexico City, Mexico.
Background: Given that dengue disease is growing and may progress to dengue hemorrhagic fever (DHF), data on economic cost and disease burden are important. However, data for Mexico are limited.
Methodology/principal Findings: Burden of dengue fever (DF) and DHF in Mexico was assessed using official databases for epidemiological information, disabilities weights from Shepard et al, the reported number of cases and deaths, and costs. Read More
Anesth Analg 2019 Jan;128(1):33-42
Department of Perioperative Medicine, Barts Heart Centre, St Bartholomew's Hospital, London, United Kingdom.
Postoperative atrial fibrillation (poAF) is the most common adverse event after cardiac surgery and is associated with increased morbidity, mortality, and hospital and intensive care unit length of stay. Despite progressive improvements in overall cardiac surgical operative mortality and postoperative morbidity, the incidence of poAF has remained unchanged at 30%-50%. A number of evidence-based recommendations regarding the perioperative management of atrial fibrillation (AF) have been released from leading cardiovascular societies in recent years; however, it is unknown how closely these guidelines are being followed by medical practitioners. Read More
J Thorac Imaging 2018 Dec 13. Epub 2018 Dec 13.
Department of Diagnostic and Interventional Radiology, University Hospital of Heidelberg.
Novel therapeutic options in chronic obstructive pulmonary disease (COPD) require delicate patient selection and thus demand for expert radiologists visually and quantitatively evaluating high-resolution computed tomography (CT) with additional functional acquisitions such as paired inspiratory-expiratory scans or dynamic airway CT. The differentiation between emphysema-dominant and airway-dominant COPD phenotypes by imaging has immediate clinical value for patient management. Assessment of emphysema severity, distribution patterns, and fissure integrity are essential for stratifying patients for different surgical and endoscopic lung volume reduction procedures. Read More
J Med Econ 2018 Dec 14:1-28. Epub 2018 Dec 14.
e Market Access, Health Economics and Outcomes Research , Bayer Yakuhin, Ltd , Tokyo , Japan.
Aims: To estimate the impact of anti-vascular endothelial growth factor (VEGF) agents on visual impairment and blindness avoided in patients with diabetic macular edema (DME) and on associated patient and caregiver productivity loss in Japan.
Methods: We compared the impact of current care (estimated at 53.8% utilization of anti-VEGF agents using current data) with that of hypothetical care (characterized by a higher utilization of anti-VEGF agents [80. Read More
G Ital Nefrol 2018 Dec;35(6)
Psicologa Clinica, Psicoterapeuta Sistemico Relazionale IIPR, Psicologa Clinica Ismett, Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione - IRCCS, Palermo.
Health care workers need artificial intelligence. Artificial intelligence is a set of studies and techniques that tend to the realization of machines, which solve complex problems automatically, simulating or emulating human intelligence activities. Human intelligence is innate, creative, emotional, sporting, social in the collective and connected future. Read More
Small 2018 Dec 14:e1804191. Epub 2018 Dec 14.
State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, Center of Advanced Pharmaceuticals and Biomaterials, China Pharmaceutical University, Nanjing, 210009, P. R. China.
Gastric cancer remains one of the most lethal cancers with high incidence and mortality worldwide. The majority of gastric cancer patients are those who have first been diagnosed in advanced stage, in which the standard chemo-radiotherapy produces limited benefit along with severe general toxicity, thus the demand for improved therapeutic efficacy and decreased side effects drives the development of novel therapeutic strategies. Here, a neoadjuvant chemotherapy based on Abraxane/human neutrophils (NEs) cytopharmaceuticals with radiotherapy is presented for effective cancer treatment. Read More
J Cosmet Dermatol 2018 Dec;17(6):1200-1204
Department of Dermatology & Venereology, Medical School, Zagazig University, Cairo, Egypt.
Skin aging is a complex biological process that arises from two basic processes: intrinsic aging (influenced by genetics factors, cellular metabolism, hormone, and metabolic processes) and extrinsic aging caused by chronic light exposure, pollution, ionizing radiation, chemicals, toxins (Expert Opin Biol Ther. 2008;8:393). Intrinsic aging called also chronological aging is observed in sun-protected skin of elderly persons. Read More
Int J Dermatol 2018 Dec 13. Epub 2018 Dec 13.
Dermatology and Plastic Surgery Institute, Cleveland Clinic, Cleveland, OH, USA.
Background: A significant number of pigmented lesions are biopsied to rule out melanoma, but most will be benign. MelaFind is a highly sensitive, noninvasive computer-assisted system to aid in clinical diagnosis of melanoma.
Methods: A total of 140 high-risk patients were followed by one expert dermatologist. Read More
Community Dent Oral Epidemiol 2018 Dec 13. Epub 2018 Dec 13.
Department of Preventive and Social Dentistry, Kyung Hee University, Seoul, Korea.
Aim: The aims of this study were to examine inequalities in periodontitis and tooth loss among South Korean adults using the Wright's Neo-Marxian social class (NMSC) indicator and to assess the impact of material, psychosocial, health behavioural and workplace environmental factors in the association of social class with oral health.
Methods: This study used the data from the 4th Korea National Health and Nutrition Examination Survey with 6710 participants aged 19-54 years old. Participants were classified into 12 social class positions based on the Wright's social class map. Read More
AIDS Rev 2018 ;20(4):187-204
Sexually Transmitted infections Unit, Centro Sanitario Sandoval. Madrid, Spain.
Nearly 1 million people become infected every day with any of the four major curable sexually transmitted infections (STIs), namely trichomoniasis, chlamydia, gonorrhea, and syphilis. Despite huge global incidence, STIs remain as neglected diseases. The success of antiretrovirals for halting progression to AIDS in HIV-infected individuals and for stopping HIV transmission to uninfected contacts, either as pre- or post-exposure -prophylaxis, has to lead to increased risky sexual behaviors through risk compensation. Read More
BMC Infect Dis 2018 Dec 14;18(1):659. Epub 2018 Dec 14.
Département des Maladies infectieuses et tropicales, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, 103, Grande-Rue de la Croix-Rousse, 69317, cedex 04, Lyon, France.
Background: Nontuberculous mycobacteria (NTM) lung diseases are increasingly recognized as chronic opportunistic infections, occurring in individuals with a wide variety of underlying conditions. In the absence of systemic immunodeficiency, decision of NTM lung disease treatment must relies on a careful risk/benefit assessment, given the requirement of long-term administration of multidrug therapies supported by limited evidence. The primary objective was to identify the factors associated with anti-NTM treatment initiation. Read More
J Cardiol Cases 2015 Jan 26;11(1):10-13. Epub 2014 Sep 26.
Department of Cardiology and Angiology I, Heart Center, University of Freiburg, Freiburg, Germany.
Background: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is characterized by recurrent syncopes and sudden cardiac death triggered by sympathetic activation in young individuals without structural heart disease and a normal baseline electrocardiogram. There is reason to question whether the current expert consensus treatment recommendation, tolerated β-blockade alone or in combination with low-dose flecainide, is the antiarrhythmic treatment strategy in CPVT, as high doses of β-blockers may eventually lead to adverse side effects and β-blocker discontinuation. Indeed, β-blocker non-compliance accounts for around 5% of sudden cardiac deaths in CPVT patients. Read More
Am J Lifestyle Med 2018 Nov-Dec;12(6):436-447. Epub 2017 May 19.
Department of Exercise & Sport Sciences, Ithaca College, Ithaca, New York (GAS, SH, KC, LC).
Health and wellness coaching (HWC) for lifestyle behavior change is emerging as a practice, role, and profession, in diverse health care, employee wellness, and community settings. Health care professionals apply HWC as a behavior change methodology for the prevention and treatment of diabetes, hypertension, hyperlipidemia, heart disease, cancer, and other chronic disorders. The purpose of this systematic review was to provide a comprehensive and organized compendium of HWC literature. Read More
Rev Esp Quimioter 2018 Dec 13. Epub 2018 Dec 13.
Benito Almirante, Servicio de Enfermedades Infecciosas, Hospital Universitario Vall d'Hebron Passeig de la Vall d'Hebron, 119-129 - 08035 Barcelona, Spain.
Objective: Clostridium difficile infections have a high recurrence rate, which can complicate the prognosis of affected patients. It is therefore important to establish an early detection and an appropriate therapeutic strategy. The objective of this manuscript was to gather the opinion of an expert group about the predictive factors of poor progression, as well as when to use fidaxomicin in different groups of high-risk patients. Read More
J Spine Surg 2018 Sep;4(3):638-644
Department of Orthopedic Surgery, Norton Leatherman Spine Center, Louisville, KY, USA.
Achieving fixation and fusion across the lumbosacral junction has been a challenge for spinal deformity surgeons ever since the development of instrumentation. The S2 alar-iliac (S2AI) trajectory has been introduced as a method of pelvic fixation to decrease strain on S1 screws. The S2AI screws differ in several ways from traditional iliac screws. Read More
IEEE J Transl Eng Health Med 2018 23;6:2800810. Epub 2018 Nov 23.
Computer Science DepartmentThe University of Texas at DallasRichardsonTX75080USA.
Management of heart failure is a major health care challenge. Healthcare providers are expected to use best practices described in clinical practice guidelines, which typically consist of a long series of complex rules. For heart failure management, the relevant guidelines are nearly 80 pages long. Read More
Eur Respir J 2018 Dec 13. Epub 2018 Dec 13.
San Diego School of Medicine, University of California, La Jolla, CA, USA.
Until 20 years ago the treatment of pulmonary arterial hypertension (PAH) was based on case reports and small series, and was largely ineffectual. As a deeper understanding of the pathogenesis and pathophysiology of PAH evolved over the subsequent two decades, coupled with epidemiological studies defining the clinical and demographic characteristics of the condition, a renewed interest in treatment development emerged through collaborations between international experts, industry and regulatory agencies. These efforts led to the performance of robust, high-quality clinical trials of novel therapies that targeted putative pathogenic pathways, leading to the approval of more than 10 novel therapies that have beneficially impacted both the quality and duration of life. Read More
Eur Respir J 2018 Dec 13. Epub 2018 Dec 13.
Dept of Pulmonary Circulation and Cardidology, Medical Center for Postgraduate Education, ECZ-Otwock, Otwock, Poland.
A revised diagnostic algorithm provides guidelines for the diagnosis of patients with suspected pulmonary hypertension, both prior to and following referral to expert centres, and includes recommendations for expedited referral of high-risk or complicated patients and patients with confounding comorbidities. New recommendations for screening high-risk groups are given, and current diagnostic tools and emerging diagnostic technologies are reviewed. Read More
Pharmacol Rev 2019 Jan 13;71(1):1-19. Epub 2018 Dec 13.
Genomic Medicine Institute, Lerner Research Institute (F.C., C.E.) and Taussig Cancer Institute (C.E.), Cleveland Clinic, Cleveland, Ohio; Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio (F.C., C.E.); CASE Comprehensive Cancer Center (F.C., C.E.) and Department of Genetics and Genome Sciences (C.E.), Case Western Reserve University School of Medicine, Cleveland, Ohio; Departments of Bioinformatics and Computational Biology and Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas (H.L.); Bakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, California (A.J.B.); Center for Data-Driven Insights and Innovation, University of California Health, Oakland, California (A.J.B.); Cancer and Inflammation Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, National Cancer Institute at Frederick, Frederick, Maryland (R.N.); and Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel (R.N.)
Recent remarkable advances in genome sequencing have enabled detailed maps of identified and interpreted genomic variation, dubbed "mutanomes." The availability of thousands of exome/genome sequencing data has prompted the emergence of new challenges in the identification of novel druggable targets and therapeutic strategies. Typically, mutanomes are viewed as one- or two-dimensional. Read More
J Craniomaxillofac Surg 2018 Nov 16. Epub 2018 Nov 16.
University of Bordeaux, Institut de Mécanique et d'Ingénierie, CNRS UMR 5295, FR-33405 Talence, France.
Purpose: The purpose of this study is to pre-validate an inovative implant concept, and to compare the behavior of the mandibular condyle against a commercial Biomet implant in an ex vivo model and present results of the first cadaveric studies.
Materials And Methods: Three experimental cadaveric condyles were tested under three conditions: one intact, another with the Biomet model, and one with the innovative concept. The condyle was tested with a reaction of 300 N in all situations and the principal strains were measured. Read More
Vaccine 2018 Dec 10. Epub 2018 Dec 10.
Department of Infectious Disease Epidemiology, Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, Keppel Street, WC1E 7HT London, United Kingdom; Modelling and Economics Unit, Public Health England, 61 Colindale Avenue, NW9 5EQ London, United Kingdom. Electronic address:
Background: National Immunisation Technical Advisory Groups (NITAGs) are multi-disciplinary expert groups that provide policy-makers with independent, evidence-based advice on vaccination. Between 2008 and 2017, the SIVAC Initiative supported establishment and strengthening of NITAGs in low and lower-middle income countries though its impact was never assessed quantitatively.
Aim: To quantitatively assess whether SIVAC support is associated with a faster rate at which NITAGs became functional based on six performance indicators. Read More
Neuroimage Clin 2018 Dec 3. Epub 2018 Dec 3.
Dept. of Neuroradiology, University Hospital Carl Gustav Carus', Technische Universität Dresden, Dresden, SN, Germany.
Background: Magnetic resonance imaging (MRI) is used to follow-up multiple sclerosis (MS) and evaluate disease progression and therapy response via lesion quantification. However, there is a lack of automated post-processing techniques to quantify individual MS lesion change.
Objective: The present study developed a secondary post-processing algorithm for MS lesion segmentation routine to quantify individual changes in volume over time. Read More
Int J Nurs Stud 2018 Nov 30. Epub 2018 Nov 30.
Centre for Research in Public Health and Community Care, University of Hertfordshire, College Lane, Hatfield, Hertfordshire, AL10 9AB, United Kingdom. Electronic address:
Background: There are an increasing number of interventions to improve hospital care for patients with dementia. Evidence for their impact on staff actions and patient outcomes is, however, limited and context dependent.
Objective: To explain the factors that support hospital staff to provide dementia sensitive care and with what outcomes for patients with dementia. Read More
J Am Coll Cardiol 2018 Dec;72(24):3158-3176
Heidelberg University Hospital, Heidelberg, Germany; Department of Cardiology, McGill University Health Centre, Montreal, Canada; Department of Diagnostic Radiology, McGill University Health Centre, Montreal, Canada. Electronic address:
This JACC Scientific Expert Panel provides consensus recommendations for an update of the cardiovascular magnetic resonance (CMR) diagnostic criteria for myocardial inflammation in patients with suspected acute or active myocardial inflammation (Lake Louise Criteria) that include options to use parametric mapping techniques. While each parameter may indicate myocardial inflammation, the authors propose that CMR provides strong evidence for myocardial inflammation, with increasing specificity, if the CMR scan demonstrates the combination of myocardial edema with other CMR markers of inflammatory myocardial injury. This is based on at least one T2-based criterion (global or regional increase of myocardial T2 relaxation time or an increased signal intensity in T2-weighted CMR images), with at least one T1-based criterion (increased myocardial T1, extracellular volume, or late gadolinium enhancement). Read More
Addict Sci Clin Pract 2018 Dec 13;13(1):25. Epub 2018 Dec 13.
Center for Innovation to Implementation, Palo Alto Health Care System, 795 Willow Rd, MC152, Palo Alto, CA, 94304, USA.
Background: In the US, emergency room visits and overdoses related to prescription opioids have soared and the rates of illicit opioid use, including heroin and fentanyl, are increasing. Opioid use disorder (OUD) is associated with higher morbidity and mortality, higher HIV and HCV infection rates, and criminal behavior. Opioid agonist therapy (OAT; methadone and buprenorphine) is proven to be effective in treating OUD and decreasing its negative consequences. Read More
Int J Environ Res Public Health 2018 Dec 9;15(12). Epub 2018 Dec 9.
Biomedical Informatics Group, Departamento de Lenguajes Sistemas Informáticos e Ingeniería de Software & Departamento de Inteligencia Artificial, Escuela Técnica Superior de Ingenieros Informáticos, Universidad Politécnica de Madrid, 28660 Madrid, Spain.
The Internet and social media is an enormous source of information. Health social networks and online collaborative environments enable users to create shared content that afterwards can be discussed. The aim of this paper is to present a novel methodology designed for quantifying relevant information provided by different participants in clinical online discussions. Read More
Int J Environ Res Public Health 2018 Dec 7;15(12). Epub 2018 Dec 7.
Department of Health Psychology, Faculty of Medicine, PJ Safarik University in Kosice, Trieda SNP 1, 04011 Kosice, Slovakia.
Careful conceptualization and differentiation of both spirituality and religiosity is a necessary precondition for understanding the potential role they play in health, whether physical or mental. The aim of this study was to explore the associations of spirituality with self-rated health, health complaints, and life satisfaction of adolescents with the moderating role of religiosity. Data from the Health Behaviour in School-aged Children study conducted in 2014 in Slovakia were used. Read More
Neurosurg Focus 2018 Dec;45(6):E10
OBJECTIVESymptomatic cervical spondylosis with or without radiculopathy can ground an active-duty military pilot if left untreated. Surgically treated cervical spondylosis may be a waiverable condition and allow return to flying status, but a waiver is based on expert opinion and not on recent published data. Previous studies on rates of return to active duty status following anterior cervical spine surgery have not differentiated these rates among military specialty occupations. Read More
J Neurosurg 2018 Dec;129(Suppl1):111-117
OBJECTIVEThe authors developed a new, real-time interactive inverse planning approach, based on a fully convex framework, to be used for Gamma Knife radiosurgery.METHODSThe convex framework is based on the precomputation of a dictionary composed of the individual dose distributions of all possible shots, considering all their possible locations, sizes, and shapes inside the target volume. The convex problem is solved to determine the plan, i. Read More
Respiration 2018 Dec 13:1-12. Epub 2018 Dec 13.
Department of Pulmonary Disease, Erasmus Medical Centre, University Hospital Rotterdam, Rotterdam, The Netherlands.
Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease with a dismal survival rate of only 3 years and no curative pharmacological therapy. The recent approval of 2 anti-fibrotic drugs (nintedanib and pirfenidone) that slow disease progression has provided some hope for patients. However, effectively managing anti-fibrotic treatment can be a challenge due to tolerability issues, the presence of pulmonary and extra-pulmonary comorbidities, and the need for concomitant medications in many patients. Read More
Nurse Educ Pract 2018 Dec 1;34:145-149. Epub 2018 Dec 1.
Northern Michigan University, School of Nursing, 2301 New Science Facility, 1401 Presque Isle Avenue, Marquette, MI, 49855, USA. Electronic address:
Faculty in a baccalaureate nursing (BSN) program recognized that fundamentals students often expressed a lack of confidence regarding translating knowledge and skills from long-term care environments into acute medical-surgical environments. This study used Benner's novice to expert framework as the basis for designing and implementing a peer-coached student led simulation with the aim of easing student transition from novice to advanced beginner. A mixed-methods descriptive design was used to gather and analyze qualitative data from peer-coach and learner focus groups. Read More
Cogn Psychol 2018 Dec 10;109:1-25. Epub 2018 Dec 10.
Cognitive Science Department, Rensselaer Polytechnic Institute, United States.
Tetris is a complex task notable for the increasingly substantial demands it makes on perception, decision-making, and action as the game is played. To investigate these issues, we collected data on 39 features of Tetris play for each Tetris zoid (piece), for up to 16 levels of difficulty, as each of 240 players played an hour of Tetris under laboratory conditions. Using only early (level 1) data, we conducted a Principle Component Analysis which found intriguing differences among its three, statistically significant, principle components. Read More
PLoS One 2018 13;13(12):e0208888. Epub 2018 Dec 13.
Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Canada.
Background: An increasing number of people are living with multiple chronic conditions and it is unclear which quality indicators should be used to guide care for this population.
Objective: To critically appraise and select the most appropriate set of quality indicators for ambulatory care for older adults with five selected disease combinations.
Methods: A two-round web-based Delphi process was used to critically appraise and select quality of care indicators for older adults with diabetes and comorbidities. Read More
PLoS One 2018 13;13(12):e0208714. Epub 2018 Dec 13.
International Livestock Research Institute, Sustainable Livestock Systems, Nairobi, Kenya.
To target food security interventions for smallholder households, decision makers need large-scale information, such as maps on poverty, food security and key livelihood activities. Such information is often based on expert knowledge or aggregated data, despite the fact that food security and poverty are driven largely by processes at the household level. At present, it is unclear if and how household level information can contribute to the spatial prediction of such welfare indicators or to what extent local variability is ignored by current mapping efforts. Read More
Traffic Inj Prev 2018 Dec 13:1-6. Epub 2018 Dec 13.
d Department of Orthopaedics and Traumatology , North Kymi Hospital , Kouvola , Finland.
Objective: In Finland, the severity of road traffic injuries is determined using the International Classification of Diseases, 10th Revision, Finnish Modification (ICD-10-FM) injury codes from Finnish Hospital Discharge data and the automatic conversion tool (ICD-AIS map) developed by the Association for the Advancement of Automotive Medicine (AAAM). The aim of this study was to evaluate the ability of the ICD-AIS map to identify seriously injured patients due to traffic accidents in Finnish injury data by comparing the severity rating generated by an expert and by the ICD-AIS map.
Methods: Our data came from the North Kymi Hospital (level 2 trauma center at the time of the study). Read More
Neuroinformatics 2018 Dec 12. Epub 2018 Dec 12.
Biomedical Imaging Group Rotterdam, Departments of Medical Informatics and Radiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Microscopic images of neuronal cells provide essential structural information about the key constituents of the brain and form the basis of many neuroscientific studies. Computational analyses of the morphological properties of the captured neurons require first converting the structural information into digital tree-like reconstructions. Many dedicated computational methods and corresponding software tools have been and are continuously being developed with the aim to automate this step while achieving human-comparable reconstruction accuracy. Read More
Neurology 2018 Dec 12. Epub 2018 Dec 12.
From Université Lyon (S.P., T.D., C.L., E.M., E.B., S.T.), Institut des Sciences Cognitives-Marc Jeannerod, CNRS, UMR 5229, Bron; Hospices Civils de Lyon (S.P., T.D., C.C., C.L., E.M., H.M., E.B., S.T.), Hôpital Neurologique Pierre Wertheimer, Service de Neurologie C, Centre Expert Parkinson, Bron; Université Lyon (C.L., E.B., D.M.-B., S.T.), Faculté de Médecine Lyon Sud Charles Mérieux, Oullins; Hospices Civils de Lyon (D.M.-B.), Service de Biostatistique, Lyon; and Université Lyon (D.M.-B.), Laboratoire de Biométrie et Biologie Évolutive, CNRS, UMR 5558, Pierre Benite, France.
Objective: To determine the time course of hazard for motor and nonmotor milestones of Parkinson disease (PD) in the long term and to investigate whether risk scales nonlinearly with time is instrumental in identifying changes in pathological processes and evaluating disease-modifying therapies in PD.
Methods: Outpatients with PD at the Lyon University Movement Disorders Center were evaluated for 7 clinical milestones in this retrospective cohort study, encompassing 4 domains of PD progression: (1) motor (motor fluctuations, dyskinesias); (2) axial (postural instability and falls, freezing of gait); (3) neuropsychiatric (impulse control disorders, hallucinations); and (4) cognitive (dementia) complications. For each complication, we estimated the outcome-specific hazard using parsimonious smooth parametric Poisson regression models allowing for nonlinear scaling over disease duration, age at diagnosis, current age, and their interaction. Read More
BMJ 2018 Dec 12;363:k5028. Epub 2018 Dec 12.
Centre for Diet & Activity Research, MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.
BMJ 2018 Dec 12;363:k5163. Epub 2018 Dec 12.
Queen Mary University, London, UK
Acta Biomater 2019 Jan 26;83:37-54. Epub 2018 Oct 26.
LBPS/CSPBAT, UMR CNRS 7244, Institut Galilée, Université Paris 13, Sorbonne Paris Cité, 99 Avenue JB Clément, 93340 Villetaneuse, France.
Implanted biomaterials play a key role in the current success of orthopedic and dental procedures. Pure titanium and its alloys are the most commonly used materials for permanent implants in contact with bone. However, implant-related infections remain among the leading reasons for failure. Read More
BMC Public Health 2018 Dec 13;18(Suppl 4):1309. Epub 2018 Dec 13.
World Health Organization Country Office, Abuja, Nigeria.
Background: Despite concerted global efforts being made to eradicate poliomyelitis, the wild poliovirus still circulates in three countries, including Nigeria. In addition, Nigeria experiences occasional outbreaks of the circulating vaccine-derived poliovirus type 2 (cVDPV2). Vaccine rejection by caregivers persists in some parts of northern Nigeria, which compromises the quality of supplemental immunization activities (SIAs). Read More
BMC Public Health 2018 Dec 13;18(Suppl 4):1304. Epub 2018 Dec 13.
World Health Organization, Country Representative Office, Abuja, Nigeria.
Background: The Global Commission for the Certification of the Eradication of Poliomyelitis will declare the world free of wild poliovirus transmission when no wild virus has been found in at least 3 consecutive years, and all laboratories possessing wild poliovirus materials have adopted appropriate measures of containment. Nigeria has made progress towards poliomyelitis eradication with the latest reported WPV type 1 on 21 Aug 2016 after 2 years without any case. This milestone achievement was followed by an inventory of biomedical laboratories completed in November 2015 with the destruction of all identified infectious materials. Read More
J Med Screen 2018 Dec 12:969141318814869. Epub 2018 Dec 12.
1 Department for Health Evidence, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
Objectives: We investigated whether changes in mammographic technique and screening policy have improved mammographic sensitivity, and elongated the mean sojourn time, since the introduction of biennial breast cancer screening in Nijmegen, the Netherlands, in 1975.
Methods: Maximum likelihood estimation, non-linear regression, and Markov Chain Monte Carlo simulation were used to estimate test sensitivity, mean sojourn time, and underlying breast cancer incidence in four time periods, covering 40 years of breast cancer screening in Nijmegen (1975-2012).
Results: Maximum likelihood estimation generated an estimated test sensitivity of approximately 90% and a mean sojourn time around three years, while the estimates based on non-linear regression and Markov Chain Monte Carlo simulation were 80% and four years, respectively. Read More
Mult Scler 2018 Dec 13:1352458518815602. Epub 2018 Dec 13.
Department of Neurology, CHU de Toulouse, Toulouse, France.
The care of multiple sclerosis (MS) in France is based on two complementary interlinked networks: MS expert centers in university hospitals and regional networks of neurologists. The routine use of European database for multiple sclerosis (EDMUS) in all those centers has paved the way for the constitution of a national registry, designated as Observatoire Français de la Sclérose En Plaques (OFSEP). It promotes a prospective, standardized, high-quality, and multimodal collection of data. Read More
Expert Opin Biol Ther 2018 Dec 13:1-11. Epub 2018 Dec 13.
a Biotechnology Research Institute, Celltrion Inc , Incheon , Republic of Korea.
Objectives: Therapeutic monoclonal antibody biosimilars are expected to help reduce the sizeable economic burden of targeted treatments. Trastuzumab (Herceptin®), a recombinant humanized monoclonal antibody that binds to the extracellular domain of HER2, is approved for use in HER2-overexpressing breast cancer (in both the adjuvant and metastatic settings) and HER2-positive gastric cancer. CT-P6 (Herzuma®) is a biosimilar of trastuzumab, designed to bind with high affinity and specificity to the same HER2 epitope as the reference product. Read More