2,053 results match your criteria Expert Review of Cardiovascular Therapy[Journal]


Link between coffee and atrial fibrillation debunked?

Expert Rev Cardiovasc Ther 2018 Dec 4. Epub 2018 Dec 4.

a Department of Surgical, Medical and Dental Department of Morphological Sciences related to Transplant, Oncology and Regenerative Medicine , University of Modena and Reggio Emilia , Italy.

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http://dx.doi.org/10.1080/14779072.2019.1556096DOI Listing
December 2018
1 Read

Clinical management in the takotsubo syndrome.

Expert Rev Cardiovasc Ther 2018 Dec 4. Epub 2018 Dec 4.

a Department of Cardiology , Sahlgrenska University Hospital , Gothenburg Sweden.

Introduction: Takotsubo syndrome (TS) is an increasingly recognized acute heart failure syndrome which is self-limiting in most cases but can result in life-threatening complications. TS is difficult to distinguish from acute myocardial infarction (AMI) early in the disease course and currently lacks evidence-based treatment recommendations. Areas covered: Based on the available literature this systematic review discusses the clinical management of patients with TS during (i) the diagnostic workup; (ii) acutely after establishing the TS diagnosis; and (iii) after recovery of cardiac function. Read More

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http://dx.doi.org/10.1080/14779072.2019.1556098DOI Listing
December 2018
7 Reads

Getting patients with cardiovascular disease to move more: cardiac rehabilitation and beyond.

Expert Rev Cardiovasc Ther 2018 Dec 3. Epub 2018 Dec 3.

a Department of Physical Therapy , College of Applied Health Sciences, University of Illinois at Chicago , Chicago , IL , USA.

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http://dx.doi.org/10.1080/14779072.2019.1556097DOI Listing
December 2018

Mitral valve prolapse.

Expert Rev Cardiovasc Ther 2018 Nov 28. Epub 2018 Nov 28.

a Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust , London , UK.

Introduction: Mitral valve prolapse is a common valve pathology with a spectrum of disease from isolated prolapse to myxomatous, multi-scallop Barlow's disease. The main complications relate to progression of mitral regurgitation, endocarditis, sudden death and stroke. The timing of intervention in patients with asymptomatic severe mitral regurgitation is controversial. Read More

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http://dx.doi.org/10.1080/14779072.2019.1553619DOI Listing
November 2018
1 Read

Exercise as a therapeutic approach to improve blood pressure in patients with peripheral arterial disease: current literature and future directions.

Expert Rev Cardiovasc Ther 2018 Nov 27. Epub 2018 Nov 27.

b Hospital Israelita Albert Einstein , SaoPaulo-SP , Brazil.

Introduction: Patients with symptomatic peripheral artery disease (PAD) exhibit reduced functional capacity and increased mortality due to cardiovascular disease. Although exercise has been a cornerstone for clinical treatment to improve walking capacity in patients with symptomatic PAD, its effects on cardiovascular parameters have been poorly explored. Areas covered: This review examines the role of exercise in improving blood pressure in patients with symptomatic PAD and summarizes the current evidence on the acute (single bout of exercise) and chronic effects of walking and resistance exercise on blood pressure and its determinants. Read More

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http://dx.doi.org/10.1080/14779072.2019.1553676DOI Listing
November 2018
2 Reads

Is it safe to stop oral anticoagulation after catheter ablation for atrial fibrillation?

Expert Rev Cardiovasc Ther 2018 Nov 21:1-11. Epub 2018 Nov 21.

a Department of Cardiology , Montefiore Medical Center, Albert Einstein College of Medicine , Bronx , NY , USA.

Introduction: Atrial fibrillation is the most common arrhythmia worldwide. Its increasing prevalence has made the use of oral anticoagulants for stroke prevention routine; however, their use after the blanking period of catheter ablation remains uncertain. Areas covered: This review outlines the pros and cons of stopping oral anticoagulation after catheter ablation. Read More

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http://dx.doi.org/10.1080/14779072.2019.1550718DOI Listing
November 2018
2 Reads

How to evaluate patients with congenital heart disease-related pulmonary arterial hypertension.

Expert Rev Cardiovasc Ther 2018 Nov 20. Epub 2018 Nov 20.

a Cardiology Department , AHEPA University Hospital, Aristotle University of Thessaloniki , Greece.

Introduction: Patients with congenital heart disease (CHD), who develop pulmonary arterial hypertension (PAH), live longer and have better quality of life compared to the past due to PAH specific therapy and improved tertiary care. Areas covered: Clinical examination, objective assessment of functional capacity, natriuretic peptide levels, cardiac imaging and haemodynamics all play a pivotal role in the evaluation, general care and management of PAH specific therapy. This review discusses the epidemiology and pathophysiology of PAH-CHD, and provides hints for the optimal evaluation of these patients. Read More

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http://dx.doi.org/10.1080/14779072.2019.1550716DOI Listing
November 2018
2 Reads

Current diagnostic strategies for dilated cardiomyopathy: a comparison of imaging techniques.

Expert Rev Cardiovasc Ther 2018 Nov 20:1-11. Epub 2018 Nov 20.

a Cardiovascular Department , Università degli Studi di Trieste , Trieste , Italy.

Introduction: Dilated cardiomyopathy (DCM) is generally thought as a final common pathway of several conditions leading to the same clinical phenotype. Multiple imaging modalities play a fundamental role in recognizing the underlying pathological substrate in DCM. Areas covered: Echocardiography represents the first reliable and easily accessible diagnostic tool, allowing the identification of associated cardiac abnormalities, such as valve disease and highlighting features associated with an adverse prognosis. Read More

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http://dx.doi.org/10.1080/14779072.2019.1550719DOI Listing
November 2018
5 Reads

Organizing stroke systems in the field for patients with suspected large vessel occlusion acute stroke.

Expert Rev Cardiovasc Ther 2018 Nov 19:1-7. Epub 2018 Nov 19.

a Department of Clinical Neurosciences , Cumming School of Medicine, University of Calgary , Calgary , Canada.

Introduction: The dawn of endovascular stroke therapy has reshaped stroke care. Eligible patients need to be rushed to capable centers for intervention. This may entail bypassing closer hospitals that could confirm the diagnosis, administer thrombolytic therapy, then transfer patients for intervention. Read More

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http://dx.doi.org/10.1080/14779072.2019.1550717DOI Listing
November 2018
1 Read

Determining the best approach to reduce the impact of exercise-induced atrial fibrillation: prevention, screening, or symptom-based treatment?

Expert Rev Cardiovasc Ther 2018 Nov 19. Epub 2018 Nov 19.

a Arrhythmia Unit, Hospital Clinic, Universitat de Barcelona , Barcelona , Catalonia , Spain.

Introduction: Regular endurance exercise over the course of many years appears to increase the risk of atrial fibrillation (AF). These data challenge the notion that the benefits of physical activity have no appreciable limits. The incidence of exercise-induced AF is expected to increase as a consequence of the popularity of extreme endurance sports. Read More

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http://dx.doi.org/10.1080/14779072.2019.1550720DOI Listing
November 2018
5 Reads

Pulmonary arterial hypertension: assessing risk to improve prognosis.

Expert Rev Cardiovasc Ther 2018 Nov 13:1-2. Epub 2018 Nov 13.

d Department of Clinical Sciences Lund , Cardiology, Lund University, and Skåne University Hospital , Lund , Sweden.

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http://dx.doi.org/10.1080/14779072.2019.1548278DOI Listing
November 2018
3 Reads

Neurological complications associated with left ventricular assist device therapy.

Expert Rev Cardiovasc Ther 2018 Dec 13;16(12):909-917. Epub 2018 Nov 13.

c Division of Cardiovascular Surgery , University of Minnesota , Minneapolis , MN , USA.

Introduction: Associated with significant morbidity and mortality, neurological complications in adult patients with left ventricular assist devices (LVAD) approaches a prevalence as high as 25%. As the number of individuals using LVAD support grows, it is increasingly important for providers to understand the hematologic and hemodynamic changes associated with LVAD implantation, the risk factors for neurological complications and their mitigation strategies. Areas covered: PubMed searches were completed using the terms 'Left ventricular assist device and stroke' (994 results) then 'Left ventricular assist device and stroke risk factors' (199 results). Read More

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http://dx.doi.org/10.1080/14779072.2018.1540300DOI Listing
December 2018
9 Reads

Radiation and the heart: systematic review of dosimetry and cardiac endpoints.

Expert Rev Cardiovasc Ther 2018 Dec 1;16(12):931-950. Epub 2018 Nov 1.

b Mayo Clinic - Department of Cardio-Oncology , Scottsdale , AZ , USA.

Introduction: Recent trials in radiotherapy have associated heart dose and survival, inadequately explained by the existing literature for radiation-related late cardiac effects.  Authors aimed to review the recent literature on cardiac dosimetry and survival/cardiac endpoints. Areas covered: Systematic review of the literature in the past 10 years (2008-2017) was performed to identify manuscripts reporting both cardiac dosimetry and survival/cardiac endpoints. Read More

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http://dx.doi.org/10.1080/14779072.2018.1538785DOI Listing
December 2018
14 Reads

Lowering the systolic blood pressure target in hypertensive patients: current controversies and future outlook.

Expert Rev Cardiovasc Ther 2018 Dec 25;16(12):889-895. Epub 2018 Oct 25.

a Division of Cardiovascular Medicine, Department of Medicine , Jichi Medical University School of Medicine , Tochigi , Japan.

Introduction: Randomized controlled trials and meta-analyses have established the benefits of blood pressure (BP) lowering. The 2017 American Heart Association/American College of Cardiology (AHA/ACC) guidelines for the management of hypertension established 130/80 mmHg as the threshold for the diagnosis- and treatment-target BP level. Area covered: The global trends are thought to be heading toward intensive BP-lowering management. Read More

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http://dx.doi.org/10.1080/14779072.2018.1538784DOI Listing
December 2018
3 Reads

Pathophysiology of essential hypertension: an update.

Expert Rev Cardiovasc Ther 2018 Dec;16(12):879-887

b Department Yoga and Physical education , Mittal Hospital and Research Centre , Ajmer , India.

Introduction: Hypertension is caused by increased cardiac output and/or increased peripheral resistance. Areas covered: The various mechanisms affecting cardiac output/peripheral resistance involved in the development of essential hypertension are covered. These include genetics; sympathetic nervous system overactivity; renal mechanisms: excess sodium intake and pressure natriuresis; vascular mechanisms: endothelial cell dysfunction and the nitric oxide pathway; hormonal mechanisms: the renin-angiotensin-aldosterone system (RAAS); obesity, obstructive sleep apnea (OSA); insulin resistance and metabolic syndrome; uric acid; vitamin D; gender differences; racial, ethnic, and environmental factors; increased left ventricular ejection force and hypertension and its association with increased basal sympathetic activity - cortical connections. Read More

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https://www.tandfonline.com/doi/full/10.1080/14779072.2018.1
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http://dx.doi.org/10.1080/14779072.2018.1540301DOI Listing
December 2018
22 Reads

Functional assessment of coronary stenosis: an overview of available techniques. Is quantitative flow ratio a step to the future?

Expert Rev Cardiovasc Ther 2018 Dec 1;16(12):951-962. Epub 2018 Nov 1.

a Division of Clinical Cardiology , A.O.R.N. Sant'Anna e San Sebastiano , Caserta , Italy.

Introduction: The assessment of coronary lesions severity has always been a relevant topic in the management of the patient undergoing coronary angiography. Fractional flow reserve (FFR) has been introduced as an objective index to determine the significance of a coronary stenosis with a positive impact on clinical outcomes has been demonstrated for FFR-guided coronary interventions. However, several technical drawbacks have been pointed out in clinical practice limiting the diffusion of FFR worldwide. Read More

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http://dx.doi.org/10.1080/14779072.2018.1540303DOI Listing
December 2018
1 Read

Targeting sudden death in heart failure with preserved ejection fraction: promise or pipedream?

Expert Rev Cardiovasc Ther 2018 12 29;16(12):875-877. Epub 2018 Oct 29.

b Brigham and Women's Hospital Heart & Vascular Center and Harvard Medical School , Boston , MA , USA.

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http://dx.doi.org/10.1080/14779072.2018.1540302DOI Listing
December 2018

FFR derived from computed tomography angiography: the experience in the UK.

Expert Rev Cardiovasc Ther 2018 Dec 25;16(12):919-929. Epub 2018 Oct 25.

a The Royal London Hospital and St Bartholomew's Hospital, London, Barts Health NHS Trust , London , UK.

Introduction: Non-invasive fractional flow reserve derived from CT coronary angiography (FFR) represents a novel technology to investigate coronary artery disease. The application of computational flow dynamics to anatomical data provides the clinician with a further functional assessment to inform decision-making in patients with coronary artery disease. In the UK FFR has received medical technology approval for use since February 2017. Read More

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http://dx.doi.org/10.1080/14779072.2018.1538786DOI Listing
December 2018
8 Reads

Expecting the unexpected: preventing and managing the consequences of coronary perforations.

Expert Rev Cardiovasc Ther 2018 Nov 19;16(11):805-814. Epub 2018 Oct 19.

a Minneapolis Heart Institute , Abbott Northwestern Hospital , Minneapolis , MN , USA.

Introduction: Coronary artery perforations are more likely to occur during percutaneous coronary intervention of complex coronary lesions, such as heavily calcified lesions and chronic total occlusions. Areas covered: Authors provide an update on the management of coronary perforations by performing a critical review of the related, recently published literature. Expert commentary: Meticulous attention to guidewire position and to device selection is critical for minimizing the risk for coronary perforation. Read More

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http://dx.doi.org/10.1080/14779072.2018.1533402DOI Listing
November 2018

Assessing and minimizing the risk of percutaneous coronary intervention in patients with chronic kidney disease.

Expert Rev Cardiovasc Ther 2018 Nov 16;16(11):825-835. Epub 2018 Oct 16.

a The Icahn School of Medicine at Mount Sinai , The Zena and Michael A. Wiener Cardiovascular Institute , New York , New York , USA.

Introduction: Chronic kidney disease (CKD) is commonly present in patients undergoing percutaneous coronary intervention (PCI). These patients frequently present with more complex coronary artery disease (CAD) and higher risk of peri-procedural and post-procedural adverse events, including bleeding, thrombotic events, and contrast-induced acute kidney injury (CI-AKI). This article contains updated knowledge and management of patients with CKD undergoing PCI. Read More

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http://dx.doi.org/10.1080/14779072.2018.1526082DOI Listing
November 2018
1 Read

Managing complications of hypertension in aortic valve stenosis patients.

Expert Rev Cardiovasc Ther 2018 Dec 19;16(12):897-907. Epub 2018 Oct 19.

b Department of Clinical Science , University of Bergen , Bergen , Norway.

Introduction: Hypertension is highly prevalent in aortic valve stenosis (AS) patients as the prevalence of both disorders increases with age. Hypertension and associated stiffening of the large arteries increase afterload and thereby influence both the transvalvular flow and the remodeling of the aortic root and the left ventricle during AS progression. Area covered: The present review gives an overview on complications of hypertension in AS, how these can be diagnosed, and potentially may be managed. Read More

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https://www.tandfonline.com/doi/full/10.1080/14779072.2018.1
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http://dx.doi.org/10.1080/14779072.2018.1535899DOI Listing
December 2018
6 Reads

Betrixaban for first-line venous thromboembolism prevention in acute medically ill patients with risk factors for venous thromboembolism.

Expert Rev Cardiovasc Ther 2018 Nov 15;16(11):845-855. Epub 2018 Oct 15.

a PERFUSE Study Group, Cardiovascular Division, Departments of Medicine , Beth Israel Deaconess Medical Center, Harvard Medical School , Boston , MA , USA.

Introduction: Compared to other direct oral anticoagulants, betrixaban has a longer half-life, smaller peak-trough variance, minimal renal clearance, and minimal hepatic Cytochrome P (CYP) metabolism. The Acute Medically Ill VTE Prevention with Extended Duration Betrixaban (APEX) trial evaluated the efficacy and safety of extended duration betrixaban compared to standard duration enoxaparin in acutely ill hospitalized patients. Areas covered: This article describes the role of betrixaban in the prevention of venous thromboembolism (VTE) in acutely ill medical patients. Read More

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https://www.tandfonline.com/doi/full/10.1080/14779072.2018.1
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http://dx.doi.org/10.1080/14779072.2018.1534068DOI Listing
November 2018
16 Reads

Optimal medical treatment of hypertension in patients with coronary artery disease.

Expert Rev Cardiovasc Ther 2018 Nov 16;16(11):815-823. Epub 2018 Oct 16.

b Division of Cardiovascular Medicine , University of Florida , Gainesville , FL , USA.

Introduction: Coronary artery disease (CAD) remains the leading cause of mortality and morbidity worldwide, and hypertension is its most prevalent modifiable risk factor. Patients with CAD and concomitant hypertension are a special population with distinct physiologic and structural alterations. Optimal blood pressure (BP) control in this population has been linked with reduction in adverse outcomes, however, excessive lowering of BP could jeopardize myocardial and cerebral perfusion. Read More

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http://dx.doi.org/10.1080/14779072.2018.1534069DOI Listing
November 2018
1 Read

Left ventricular reverse remodeling prediction in non-ischemic cardiomyopathy: present and perspectives.

Expert Rev Cardiovasc Ther 2018 11 11;16(11):771-773. Epub 2018 Oct 11.

a Cardiovascular Department , Azienda Sanitaria-Universitaria Integrata of Trieste (ASUITS) , Trieste , Italy.

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http://dx.doi.org/10.1080/14779072.2018.1533815DOI Listing
November 2018
6 Reads

Relationship between P-wave duration and the risk of atrial fibrillation.

Expert Rev Cardiovasc Ther 2018 Nov 11;16(11):837-843. Epub 2018 Oct 11.

b Epidemiological Cardiology Research Center (EPICARE), Department of Epidemiology and Prevention, and Department of Medicine, Section on Cardiology , Wake Forest School of Medicine , Winston Salem , NC , USA.

Introduction: P-wave duration (PWD) is an electrocardiographic (ECG) marker reflecting atrial conduction, and studies have shown that its prolongation is associated with atrial fibrillation. Areas covered: This review addresses the relationship between PWD and atrial fibrillation, how anatomic and physiologic changes in the atria potentiate the risk for atrial fibrillation, and how these atrial anatomic and physiologic changes relate to PWD. Other P-wave related entities, such as P-wave terminal force in V1, PR interval, and P wave axis are also addressed. Read More

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http://dx.doi.org/10.1080/14779072.2018.1533814DOI Listing
November 2018
1 Read

Associations between socioeconomic status, atrial fibrillation, and outcomes: a systematic review.

Expert Rev Cardiovasc Ther 2018 Nov 15;16(11):857-873. Epub 2018 Oct 15.

a Department of Cardiology , Aalborg University Hospital , Aalborg , Denmark.

Background: Atrial fibrillation (AF) is a growing epidemic and evidence of a relationship to socioeconomic status (SES) is inconsistent. We aimed to summarize the literature about SES and AF and defined two objectives: (1) To examine the association between SES and the risk of AF; (2) To examine the association between SES and AF-related outcomes in an AF-population.

Methods: We performed a separate search for each objective in Ovid-MEDLINE and Ovid-Embase. Read More

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https://www.tandfonline.com/doi/full/10.1080/14779072.2018.1
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http://dx.doi.org/10.1080/14779072.2018.1533118DOI Listing
November 2018
12 Reads

Stress echocardiography in valvular heart disease.

Expert Rev Cardiovasc Ther 2018 Nov 10;16(11):795-804. Epub 2018 Oct 10.

a Echocardiography Laboratory , Barts Heart Centre, St Bartholomew's Hospital , London , UK.

Introduction: The management of patients with heart valve disease can be complex. Patients may have symptoms disproportionate to the severity or the severity may be unclear. In addition, the optimal timing of intervention in patients with severe disease may be controversial. Read More

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https://www.tandfonline.com/doi/full/10.1080/14779072.2018.1
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http://dx.doi.org/10.1080/14779072.2018.1532791DOI Listing
November 2018
2 Reads

Relationship between intra-operative vein graft treatment with DuraGraft® or saline and clinical outcomes after coronary artery bypass grafting.

Expert Rev Cardiovasc Ther 2018 Dec 14;16(12):963-970. Epub 2018 Oct 14.

f Division of Aging , Brigham and Women's Hospital , Boston , MA , USA.

Background: Saphenous vein grafts (SVGs) remain the most often used conduits for coronary bypass grafting (CABG). Progressive intimal hyperplasia contributes to vein-graft disease and vein-graft failure (VGF). We compared the impact of intraoperative preservation of SVGs in a storage solution (DuraGraft®) versus heparinized saline on VGF-related outcomes after CABG. Read More

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http://dx.doi.org/10.1080/14779072.2018.1532289DOI Listing
December 2018
7 Reads

Management of advanced heart failure: a review.

Expert Rev Cardiovasc Ther 2018 Nov 15;16(11):775-794. Epub 2018 Oct 15.

a Department of Cardiology , Montpellier University Hospital , Montpellier , France.

Introduction: Heart failure (HF) has become a global pandemic. Despite recent developments in both medical and device treatments, HF incidences continues to increase. The current definition of HF restricts itself to stages at which clinical symptoms are apparent. Read More

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http://dx.doi.org/10.1080/14779072.2018.1530112DOI Listing
November 2018
9 Reads

A comparison of alternative access routes for transcatheter aortic valve implantation.

Expert Rev Cardiovasc Ther 2018 Oct 28;16(10):749-756. Epub 2018 Sep 28.

a Interventional Cardiology and Cardiovascular Surgery Centre Hospitalier Regional , Universitaire de Lille (CHRU de Lille) , Lille , France.

Introduction: Alternative transcatheter aortic valve implantation (TAVI) approaches offer the possibility of valve replacement in patients ineligible to the transfemoral route. Authors provide an updated review of the existing alternative approaches. Areas covered: A systematic review of alternative approaches for TAVI was undertaken. Read More

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http://dx.doi.org/10.1080/14779072.2018.1524295DOI Listing
October 2018
3 Reads

Contemporary techniques in percutaneous coronary intervention for bifurcation lesions.

Expert Rev Cardiovasc Ther 2018 Oct 3;16(10):725-734. Epub 2018 Oct 3.

a Amsterdam Heart Center, Department of Cardiology , Academic Medical Center, University of Amsterdam , Amsterdam , The Netherlands.

Introduction: Treatment of coronary bifurcation lesions with contemporary state-of-the-art percutaneous coronary intervention (PCI) is still associated with higher rate of adverse cardiovascular events compared to non-bifurcation lesions. Bench testing and virtual computer modeling have increased our understanding of bifurcation PCI guiding refinement in bifurcation techniques. New insights on bifurcation PCI have the potential to further improve clinical outcomes in patients presenting with bifurcation lesions. Read More

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http://dx.doi.org/10.1080/14779072.2018.1523717DOI Listing
October 2018

Optimal duration of dual antiplatelet therapy after PCI: integrating procedural complexity, bleeding risk and the acuteness of clinical presentation.

Expert Rev Cardiovasc Ther 2018 Oct 4;16(10):735-748. Epub 2018 Oct 4.

a The Zena and Michael A. Wiener Cardiovascular Institute , The Icahn School of Medicine at Mount Sinai , New York , NY , USA.

Introduction: Dual antiplatelet therapy (DAPT) with aspirin and a P2Y12 receptor inhibitor constitutes the standard of care to prevent major adverse cardiac events in patients who undergo percutaneous coronary intervention (PCI) with drug-eluting stents (DES). However, the anti-ischemic benefits of DAPT are counterbalanced by an increased risk of hemorrhagic complications, which are known to be associated with increased morbidity and mortality. While the efficacy of DAPT in patients presenting with acute coronary syndrome (ACS) has been well established, the risk-benefit balance of DAPT in other subsets of patients remain controversial. Read More

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http://dx.doi.org/10.1080/14779072.2018.1523718DOI Listing
October 2018
5 Reads

Triple antithrombotic therapy in patients with atrial fibrillation undergoing PCI: current evidence and practice.

Expert Rev Cardiovasc Ther 2018 Oct 20;16(10):715-723. Epub 2018 Sep 20.

c Division of Cardiology, Department of Medicine , University Hospital Limerick, Graduate Entry Medical School (GEMS), University of Limerick , Limerick , Ireland.

Introduction: Patients with atrial fibrillation taking oral anticoagulation and undergoing percutaneous coronary intervention with stent insertion are recommended to receive antithrombotic therapy with aspirin and P2Y receptor antagonist. This combinatory regime encompasses triple therapy (TT). Although TT reduces the risk of ischemic events such as stroke and stent thrombosis, it is associated with an increased bleeding risk. Read More

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http://dx.doi.org/10.1080/14779072.2018.1521721DOI Listing
October 2018
12 Reads

Oxygen therapy in acute myocardial infarctions: do we need to re-evaluate its necessity?

Expert Rev Cardiovasc Ther 2018 10 19;16(10):693-694. Epub 2018 Sep 19.

a Canadian VIGOUR Centre , University of Alberta , Edmonton , Alberta , Canada.

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http://dx.doi.org/10.1080/14779072.2018.1523719DOI Listing
October 2018

Frailty assessment and impact of frailty on outcomes after transcatheter aortic valve replacement.

Expert Rev Cardiovasc Ther 2018 Oct 24;16(10):757-763. Epub 2018 Sep 24.

a Division of Cardiology , St. Michael's Hospital , Toronto , Canada.

Introduction: Certain frail patients fail to achieve adequate functional or mortality benefit despite successful transcatheter aortic valve replacement (TAVR). Therefore, frailty assessment methods are becoming an important tool to identify and intervene on this high-risk patient subset for improving clinical outcomes. Areas covered: The authors provide an overview of frailty and frailty assessment tools being used in clinical practice and discuss the impact of frailty on the cardiac patients, particularly among the TAVR population. Read More

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http://dx.doi.org/10.1080/14779072.2018.1521720DOI Listing
October 2018

Strategies to manage obstructive sleep apnea to decrease the burden of atrial fibrillation.

Expert Rev Cardiovasc Ther 2018 Oct 3;16(10):707-713. Epub 2018 Sep 3.

a Heart Institute (InCor) , University of Sao Paulo Medical School , Sao Paulo , Brazil.

Introduction: In the last decades, consistent data derived from experimental, epidemiological, and clinical studies pointed obstructive sleep apnea (OSA), the most common sleep disordered breathing worldwide, as a potential risk factor for incidence and recurrence of atrial fibrillation (AF). Areas covered: This review article describes the impact of OSA on AF and discusses potential strategies for managing OSA in the AF scenario. Expert commentary: Untreated OSA seems to be one important predictor of AF treatment failure after chemical or electrical cardioversion as well as after a successful AF ablation. Read More

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http://dx.doi.org/10.1080/14779072.2018.1515013DOI Listing
October 2018
1 Read

Comparison of sodium nitroprusside and adenosine for fractional flow reserve assessment: a systematic review and meta-analysis.

Expert Rev Cardiovasc Ther 2018 Oct 24;16(10):765-770. Epub 2018 Aug 24.

a Department of Interventional Cardiology , Hospital El Cruce , Florencio Varela , Argentina.

Background: Fractional flow reserve (FFR) has become a useful tool in the assessment of physiological significance of coronary artery stenosis (CAS), and Adenosine (ADE) is associated with a high incidence of transient side effects. Sodium nitroprusside (NPS) has been proposed as an alternative vasodilator agent. A meta-analysis of studies comparing ADE and NPS for FFR assessment in the same coronary lesions was performed. Read More

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http://dx.doi.org/10.1080/14779072.2018.1513789DOI Listing
October 2018
1 Read

Utility of risk scores to predict adverse events in cardiac lead extraction.

Expert Rev Cardiovasc Ther 2018 Oct 27;16(10):695-705. Epub 2018 Aug 27.

a Second Division of Cardiovascular Diseases, Cardiac and Thoracic Department, New Santa Chiara Hospital , University of Pisa , Pisa , Italy.

Introduction: Increasing device implantations, patient comorbidities, and longer life expectancy contribute to an increased need for lead extraction. Even if transvenous lead extraction (TLE) is a highly successful procedure, some serious procedural complications are reported. In order to identify those patients who are at higher risk, risk stratification scores were proposed. Read More

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http://dx.doi.org/10.1080/14779072.2018.1513325DOI Listing
October 2018
5 Reads

Advances in medical therapy for pericardial diseases.

Expert Rev Cardiovasc Ther 2018 Sep 21;16(9):635-643. Epub 2018 Aug 21.

a University Cardiology, AOU Città della Salute e della Scienza di Torino , Torino , Italy.

Introduction: Medical therapy of pericardial diseases is moving forward to the road of evidence-based medicine and has improved in the last years because of the first randomized clinical trials in the area as well as new therapeutic options for recurrent pericarditis. Areas covered: The present review will focus on more recent advances with a special emphasis on the treatment of pericarditis, the area with more significant improvements in the last years. Medline/Pubmed Library were systematically screened with two specific key searches: 'pericarditis AND therapy' and 'pericardial effusion AND therapy'. Read More

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https://www.tandfonline.com/doi/full/10.1080/14779072.2018.1
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http://dx.doi.org/10.1080/14779072.2018.1510315DOI Listing
September 2018
8 Reads

Catheter ablation for atrial fibrillation: current patient selection and outcomes.

Expert Rev Cardiovasc Ther 2018 Sep 28;16(9):679-692. Epub 2018 Aug 28.

a Cardiac Electrophysiology Section, Cardiovascular Division , Hospital of University of Pennsylvania , Philadelphia , PA , USA.

Introduction: Atrial fibrillation (AF) is the most common cardiac arrhythmia. Ablation is an excellent treatment option for appropriately selected patients. Catheter ablation tools and techniques have evolved since AF ablation was first introduced, but pulmonary vein isolation remains the cornerstone of the procedure. Read More

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http://dx.doi.org/10.1080/14779072.2018.1510317DOI Listing
September 2018
2 Reads

Current challenges in managing comorbid heart failure and COPD.

Expert Rev Cardiovasc Ther 2018 Sep 3;16(9):653-673. Epub 2018 Sep 3.

d Respiratory Investigation Unit , Queen's University & Kingston General Hospital , Kingston , Canada.

Introduction: Heart failure (HF) with reduced ejection fraction and chronic obstructive pulmonary disease (COPD) frequently coexist, particularly in the elderly. Given their rising prevalence and the contemporary trend to longer life expectancy, overlapping HF-COPD will become a major cause of morbidity and mortality in the next decade. Areas covered: Drawing on current clinical and physiological constructs, the consequences of negative cardiopulmonary interactions on the interpretation of pulmonary function and cardiopulmonary exercise tests in HF-COPD are discussed. Read More

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http://dx.doi.org/10.1080/14779072.2018.1510319DOI Listing
September 2018
6 Reads

Cardiovascular impact of testosterone therapy for hypogonadism.

Expert Rev Cardiovasc Ther 2018 Sep 21;16(9):617-625. Epub 2018 Aug 21.

e Endocrinology Unit, Medical Department , Azienda Usl, Maggiore-Bellaria Hospital , Bologna , Italy.

Introduction: Since 2010 some evidence supporting the possible increased cardiovascular (CV) risk related to testosterone treatment (TTh) has created much debate in the scientific community. Based on these results, the US Food and Drug Administration agency has questioned TTh for aging men recognizing its value only for classical hypogonadism due to genetic or organic causes. To better clarify this topic, we scrutinized and summarized, also by using meta-analytic methods, the data generated during the last 7 years, as derived from the analysis of randomized controlled trials (RCTs) on TTh and CV risk. Read More

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https://www.tandfonline.com/doi/full/10.1080/14779072.2018.1
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http://dx.doi.org/10.1080/14779072.2018.1510314DOI Listing
September 2018
7 Reads

Antithrombotic strategies after interventional left atrial appendage closure: an update.

Expert Rev Cardiovasc Ther 2018 Sep 29;16(9):675-678. Epub 2018 Aug 29.

a Cardioangiologisches Centrum Bethanien (CCB) Frankfurt am Main , Frankfurt am Main , Germany.

Introduction: Interventional left atrial appendage occlusion (LAAO) has emerged as a valid alternative to oral anticoagulation (OAC) therapy for the prevention of ischemic stroke and systemic embolism in patients with non-valvular atrial fibrillation (AF). Areas covered: Antithrombotic therapy following interventional LAAO is critical in balancing the risk of thromboembolism and bleeding during the endothelialization of the implanted devices. In this article, the most recent clinical trials are reviewed and the current real-world antithrombotic strategies following LAAO device implantation are discussed. Read More

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http://dx.doi.org/10.1080/14779072.2018.1510316DOI Listing
September 2018

Cardiac rehabilitation and its effects on cognition in patients with coronary artery disease and heart failure.

Expert Rev Cardiovasc Ther 2018 Sep 21;16(9):645-652. Epub 2018 Aug 21.

a Faculty of Medicine and Dentistry , University of Alberta , Edmonton , Canada.

Introduction: Cardiac rehabilitation program is an evidence-based intervention and established model of exercise delivery following myocardial infarction and heart failure. Although it forms an important part of recovery and helps to prevent future events and complications, there has been little focus on its potential cognitive benefits. Areas covered: Coronary artery disease and heart failure are common heart problems associated with significant morbidity and mortality, and cognitive decline is commonly seen in affected individuals. Read More

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https://www.tandfonline.com/doi/full/10.1080/14779072.2018.1
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http://dx.doi.org/10.1080/14779072.2018.1510318DOI Listing
September 2018
14 Reads

eHealth in patients with congenital heart disease: a review.

Expert Rev Cardiovasc Ther 2018 Sep 20;16(9):627-634. Epub 2018 Aug 20.

a Department of Cardiology , Amsterdam UMC, University of Amsterdam , Amsterdam , the Netherlands.

Introduction: Mobile health (mHealth), an advanced form of eHealth is expected to drastically change the field of traditional healthcare in the near future as wearables and mobile applications are rapidly increasing in number. The majority of patients with congenital heart disease (CHD) now reach adulthood and this relative young patient population seems particularly suited for mHealth, as they require lifelong follow-up, experience high morbidity burden, and were raised in this digital era. In patients with acquired heart disease the potential of eHealth has been demonstrated, yet data are still inconclusive. Read More

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http://dx.doi.org/10.1080/14779072.2018.1508343DOI Listing
September 2018

Complications associated with cardiac resynchronization therapy upgrades versus de novo implantations.

Expert Rev Cardiovasc Ther 2018 Aug 16;16(8):607-615. Epub 2018 Jul 16.

a Division of Imaging Sciences and Biomedical Engineering , King's College London , London , UK.

Introduction: A significant number of patients undergo upgrade to cardiac resynchronization therapy (CRT). These patients tend to differ from individuals undergoing de novo CRT implantations both in terms of their baseline demographics and the etiology underlying their heart failure. Areas covered: There are several factors that need to be considered when upgrading patients to CRT, such as, venous patency. Read More

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http://dx.doi.org/10.1080/14779072.2018.1498783DOI Listing
August 2018
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PCSK9 inhibitors and LDL reduction: pharmacology, clinical implications, and future perspectives.

Expert Rev Cardiovasc Ther 2018 Aug 18;16(8):567-578. Epub 2018 Jul 18.

a Cardiology Department , University Hospital Limerick , Limerick , Ireland.

Introduction: PCSK9 inhibitors are monoclonal antibodies to proprotein convertase-subtilisin/kexin type 9 which significantly reduce LDL cholesterol concentration in vivo by inhibiting degradation of the LDL receptor in hepatocytes. The introduction of PCSK9 inhibitors heralded a new era of intensive LDL-C reduction with LDL-C concentrations lowered below levels ever thought possible with conventional treatments such as statins. With their introduction considerations regarding cost, clinical outcomes and long-term safety are paramount. Read More

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http://dx.doi.org/10.1080/14779072.2018.1497975DOI Listing
August 2018
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The current status of homocysteine as a risk factor for cardiovascular disease: a mini review.

Expert Rev Cardiovasc Ther 2018 Aug 17;16(8):559-565. Epub 2018 Jul 17.

b Department of Cardiology , INTEGRIS Baptist Medical Center , Oklahoma City , OK , USA.

Introduction: Hyperhomocysteinemia has been considered as a risk factor for systemic atherosclerosis, cardiovascular disease (CVD) and stroke and many epidemiologic and case-controlled studies have demonstrated its association with these complications. In addition, treatment of hyperhomocysteinemia with folic acid ± B vitamins prevents the development of atherosclerosis, CVD and strokes. However, subsequent prospective, randomized, placebo-controlled trials have not shown an association of high homocysteine levels or their lowering with treatment with the incidence of atherosclerosis, CVD or strokes, due possibly, to the fortification of flower with folic acid. Read More

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http://dx.doi.org/10.1080/14779072.2018.1497974DOI Listing

Mechanisms, diagnosis, and treatment of heart failure with preserved ejection fraction and diastolic dysfunction.

Expert Rev Cardiovasc Ther 2018 Aug 16;16(8):579-589. Epub 2018 Jul 16.

a Department of Clinical & Translational Science , Creighton University School of Medicine , Omaha , NE , USA.

Introduction: Heart failure with preserved ejection fraction (HFpEF) continues to be a major challenge for clinicians. Many crucial aspects of the syndrome remain unclear, including the exact pathophysiology, early diagnosis, and treatment. Patients with HFpEF are often asymptomatic late into the disease process, and treatment with medications commonly used in heart failure with reduced ejection fraction (HFrEF) has not been proven to be beneficial. Read More

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http://dx.doi.org/10.1080/14779072.2018.1497485DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287909PMC
August 2018
1 Read

Is it time to be concerned about the effects of e-cigarettes on cardiovascular health?

Expert Rev Cardiovasc Ther 2018 08 11;16(8):547-549. Epub 2018 Jul 11.

b Department of Physiology, Faculty of Medicine , University of Valencia and INCLIVA Biomedical Research Institute , Valencia , Spain.

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http://dx.doi.org/10.1080/14779072.2018.1497486DOI Listing
August 2018
1 Read