128,127 results match your criteria Expert Opinion on Drug Metabolism & Toxicology[Journal]


[Use of Negative Pressure Wound Therapy with Instillation and Dwell Time for Wound Treatment - Results of an Expert Consensus Conference].

Zentralbl Chir 2018 Dec 11;143(6):609-616. Epub 2018 Dec 11.

Unfallchirurgie, Bundeswehrkrankenhaus Berlin, Deutschland.

Rinsing wounds with wound cleansing solutions has long been a recognised cornerstone in wound management as a means of removing cell debris and surface pathogens in wound exudates. In combination with surgical debridement and topical negative pressure wound therapy (NPWT), this can facilitate the intended progression from the inflammatory to the proliferative phase of wound healing. Procedures of topical negative pressure wound therapy with instillation and a defined exposure/dwell-time of topical solutions under cyclic compression and decompression with foam dressings (NPWTi-d) can remove cellular remnants and debris that may inhibit the healing process. Read More

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December 2018
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The refractory epilepsy screening tool for Lennox-Gastaut syndrome (REST-LGS).

Epilepsy Behav 2018 Dec 8;90:148-153. Epub 2018 Dec 8.

Icahn School of Medicine at Mount Sinai Health Systems, 10 Union Square East, Suite 5G, New York, NY 10003, USA. Electronic address:

Background: The complex clinical presentation and progression of Lennox-Gastaut syndrome (LGS) can complicate the accurate diagnosis of this severe, lifelong, childhood-onset epilepsy, often resulting in suboptimal treatment. The Refractory Epilepsy Screening Tool for LGS (REST-LGS) was developed to improve the identification of patients with LGS.

Methods: Using the Modified Delphi Consensus, a group of experts developed and tested the REST-LGS Case Report Form (CRF) comprising 8 criteria (4 major, 4 minor) considered potentially indicative of LGS. Read More

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December 2018

Why we can't determine reliably the age of a subject on the basis of his maturation degree.

J Forensic Leg Med 2018 Dec 5;61:97-101. Epub 2018 Dec 5.

Past Director of the Complex Unit of Auxology, Faculty of Medicine and Surgery, Università degli Studi di Torino, Turin, Italy. Electronic address:

Background: Maturation is the irreversible biological process leading to adult form or function. The degree of maturation can be derived from the examination of maturity indicators, i.e. Read More

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December 2018
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Fabrication, modeling and optimization of lyophilized advanced platelet rich fibrin in combination with collagen-chitosan as a guided bone regeneration membrane.

Int J Biol Macromol 2018 Dec 8. Epub 2018 Dec 8.

Department of Chemical & Petroleum Engineering, Sharif University of Technology, Tehran, Iran.

In this study, lyophilized advanced platelet rich fibrin (A-PRF) was used in combination with collagen-chitosan membrane for the first time to combine advantages of both collagen and A-PRF membranes. Response surface methodology (RSM) was used to design the experimental condition and to correlate the effects of parameters, including chitosan/collagen (chit/col) weight ratio and A-PRF concentration on Young's modulus, mesenchymal stem cell (MSCs) viability and degradation rate of the membranes. Results showed that Young's modulus of the membranes was intensified by increasing chit/col weight ratio and decreasing A-PRF concentration from 3 to 8 MPa. Read More

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December 2018

The value of immunotherapy in head and neck cancer.

Expert Opin Biol Ther 2018 Dec 11. Epub 2018 Dec 11.

d Marlene and Stewart Greenebaum Comprehensive Cancer Center , University of Maryland School of Medicine , Baltimore , Maryland.

Introduction: Head and neck squamous cell carcinomas (HNSCC) previously had limited treatment options once patients had progressed on systemic chemotherapy. With recent advances, immunotherapy now plays an important role in the treatment of advanced disease with improved outcomes as compared to cytotoxic chemotherapy. Areas covered: This article reviews the effects of the immune system and how it influences the development and response to HNSCC therapy. Read More

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December 2018
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Simultaneous Co-segmentation of Tumors in PET-CT Images Using Deep Fully Convolutional Networks.

Med Phys 2018 Dec 8. Epub 2018 Dec 8.

Department of Electrical and Computer Engineering, the University of Iowa.

Purpose: To investigate the use and efficiency of 3-D deep learning, fully convolutional networks (DFCN) for simultaneous tumor co-segmentation on dual-modality non-small cell lung cancer (NSCLC) PET-CT images.

Methods: We used DFCN co-segmentation for NSCLC tumors in PET-CT images, considering both the CT and PET information. The proposed DFCN-based co-segmentation method consists of two coupled 3D-UNets with an encoder-decoder architecture, which can communicate with the other in order to share complementary information between PET and CT. Read More

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December 2018

Transforming Weakness into Strength: Photothermal-Therapy-Induced Inflammation Enhanced Cytopharmaceutical Chemotherapy as a Combination Anticancer Treatment.

Adv Mater 2018 Dec 9:e1805936. Epub 2018 Dec 9.

State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, Center of Advanced Pharmaceuticals and Biomaterials, China Pharmaceutical University, No. 24 Tongjiaxiang, Nanjing, 210009, China.

A new synergistic treatment that combines photothermal therapy (PTT) and inflammation-mediated active targeting (IMAT) chemotherapy based on cytopharmaceuticals is developed. During PTT, the photothermal tumor ablation is accompanied by an inflammatory effect and upregulation of inflammatory factors at the tumor site, which may accelerate tumor regeneration. Moreover, PTT-induced inflammation can also recruit neutrophils (NEs) to the tumor site. Read More

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December 2018

Evaluating the performance of a deep learning-based computer-aided diagnosis (DL-CAD) system for detecting and characterizing lung nodules: Comparison with the performance of double reading by radiologists.

Thorac Cancer 2018 Dec 8. Epub 2018 Dec 8.

Department of Radiology, National Cancer Center/Cancer Hospital and Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, China.

Background: The study was conducted to evaluate the performance of a state-of-the-art commercial deep learning-based computer-aided diagnosis (DL-CAD) system for detecting and characterizing pulmonary nodules.

Methods: Pulmonary nodules in 346 healthy subjects (male: female = 221:125, mean age 51 years) from a lung cancer screening program conducted from March to November 2017 were screened using a DL-CAD system and double reading independently, and their performance in nodule detection and characterization were evaluated. An expert panel combined the results of the DL-CAD system and double reading as the reference standard. Read More

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December 2018

Fetal myelomeningocele surgery: Only treating the tip of the iceberg.

Prenat Diagn 2018 Dec 10. Epub 2018 Dec 10.

Fetal Medicine Unit, Department of Obstetrics & Gynaecology, Mount Sinai Hospital and University of Toronto, Toronto, Canada.

Objective: Fetal myelomeningocele (fMMC) surgery improves infant outcomes when compared with postnatal surgery. Surgical selection criteria and the option of pregnancy termination, however, limit the number of cases that are eligible for prenatal surgery. We aimed to quantify what proportion of cases could ultimately benefit from fetal therapy. Read More

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December 2018

A resistance exercise set for a total body workout for adults with intellectual disabilities, a pilot study.

J Appl Res Intellect Disabil 2018 Dec 10. Epub 2018 Dec 10.

Intellectual Disability Medicine, Department of General Practice, Erasmus MC University Medical Centre, Rotterdam, The Netherlands.

Background: Resistance training has beneficial effects on fitness levels, cardiovascular disease risk, risk of sarcopenia and on performing activities of daily living. The focus of this study is to design a total body resistance exercise set for adults with intellectual disabilities (RESID) with minimal equipment required and to test its feasibility.

Method: The RESID was selected in an expert meeting, and its feasibility was determined in a cross-sectional pilot study. Read More

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December 2018

The American Headache Society Position Statement On Integrating New Migraine Treatments Into Clinical Practice.

Authors:

Headache 2018 Dec 10. Epub 2018 Dec 10.

Objective: To provide healthcare professionals with updated guidance in the use of novel preventive and acute treatments for migraine in adults.

Background: The principles of preventive and acute pharmacotherapy for patients with migraine have been outlined previously, but the emergence of new technologies and treatments, as well as new formulations of previously established treatments, has created a need for an updated guidance on the preventive and acute treatment of migraine.

Methods: This statement is based on a review of existing guidelines and principles for preventive and acute treatment of migraine, as well as the results of recent clinical trials of drugs and devices for these indications. Read More

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December 2018

The genetic profile of bone marrow transplant patients in different samples of forensic interest.

Forensic Sci Med Pathol 2018 Dec 10. Epub 2018 Dec 10.

Unit of Legal Medicine, Department of Physiology and Pharmacology, University of Cantabria, Av Cardenal Herrera Oria s/n, 39011, Santander, Spain.

Humans constantly lose epithelial cells, and these biological traces are frequently studied in the context of criminal investigations. The objective of this work was to examine the genetic profile in samples of forensic interest (nail and skin epithelial cells) of bone marrow transplant patients and discuss its forensic and clinical implications. The genetic profile of nail, epidermal cells and blood samples of patients receiving HSCT was analyzed by the amplification and sequencing of 38 insertion/deletion polymorphisms and 15 short tandem repeat polymorphisms. Read More

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December 2018
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Integrating self-management into daily life following primary treatment: head and neck cancer survivors' perspectives.

J Cancer Surviv 2018 Dec 8. Epub 2018 Dec 8.

School of Nursing and Human Sciences, Dublin City University, Dublin, Ireland.

Background: Self-management may help cancer survivors to better deal with challenges to their physical, functional, social and psychological well-being presented by cancer and its treatment. Nonetheless, little is known about how people integrate cancer self-management practices into their daily lives. The aim of this study was to describe and characterise the processes through which head and neck cancer (HNC) survivors attempt to integrate self-management into their daily lives following primary treatment. Read More

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December 2018
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Introducing off-the-job training to cardiovascular surgical residency training: a new era of developing competent cardiovascular surgeons.

Authors:
Hitoshi Yokoyama

Surg Today 2018 Dec 7. Epub 2018 Dec 7.

Department of Cardiovascular Surgery, Fukushima Medical University, 1 Hikarigaoka, Fukushima City, Fukushima, 960-8072, Japan.

Purpose: This review summarizes the recent progress made in understanding the skill acquisition process of achieving expert status in various fields that require fine motor skills. We discuss the attempts to apply this progress to develop competent surgeons.

Methods: We reviewed the existing literature, using the keywords "surgical training", "skill acquisition", and "simulator-based training", using Medline, as well as recent books and chapters related to these issues. Read More

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December 2018

EDUCATION AND TRAINING IN EUROPE TO SUPPORT LOW-DOSE RADIATION PHYSICS AND RADIOBIOLOGY.

Radiat Prot Dosimetry 2018 Dec 11. Epub 2018 Dec 11.

Physics Department, University of Pavia, Pavia, Italy.

The success of any research programme is dependent on a continuing influx of new expertise, and continuing education to ensure the newest technologies and methods are exploited. In the past decade, a strategic approach has been used to build up the research expertise in the area of radiation protection and risk estimation. The High Level Expert Group (HLEG, www. Read More

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December 2018

Predicting the Future: Using Simulation Modeling to Forecast Patient Flow on General Medicine Units.

J Hosp Med 2018 Nov 28. Epub 2018 Nov 28.

Assistant Vice President of Health Sciences for Interprofessional Education and Collaborative Care, Virginia Commonwealth University Health System, Richmond, Virginia, USA.

Background: Hospitals are complex adaptive systems within which multiple components such as patients, practitioners, facilities, and technology interact. A careful approach to optimization of this complex system is needed because any change can result in unexpected deleterious effects. One such approach is discrete event simulation, in which what-if scenarios allow researchers to predict the impact of a proposed change on the system. Read More

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November 2018

Costs and consequences of chronic pain due to musculoskeletal disorders from a health system perspective in Chile.

Pain Rep 2018 Sep-Oct;3(5):e656. Epub 2018 Sep 10.

Health Technology Assessment Unit, Center of Clinical Research, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.

Background: Chronic pain is a prevalent and distressing condition caused by an unceasing pain lasting more than 3 months or a pain that persists beyond the normal healing time. There is evidence of inadequate management partly explained by the unawareness regarding the magnitude of the problem.

Objectives: To estimate the annual expected costs and consequences of chronic pain caused by musculoskeletal diseases from the health system perspective in Chile. Read More

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September 2018

Learning to Predict Ischemic Stroke Growth on Acute CT Perfusion Data by Interpolating Low-Dimensional Shape Representations.

Front Neurol 2018 26;9:989. Epub 2018 Nov 26.

Institute of Medical Informatics, University of Lübeck, Lübeck, Germany.

Cerebrovascular diseases, in particular ischemic stroke, are one of the leading global causes of death in developed countries. Perfusion CT and/or MRI are ideal imaging modalities for characterizing affected ischemic tissue in the hyper-acute phase. If infarct growth over time could be predicted accurately from functional acute imaging protocols together with advanced machine-learning based image analysis, the expected benefits of treatment options could be better weighted against potential risks. Read More

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November 2018

A Novel Interface for the Graphical Analysis of Music Practice Behaviors.

Front Psychol 2018 26;9:2292. Epub 2018 Nov 26.

School of Electronic Engineering and Computer Science, Queen Mary University of London, London, United Kingdom.

Practice is an essential part of music training, but critical content-based analyses of practice behaviors still lack tools for conveying informative representation of practice sessions. To bridge this gap, we present a novel visualization system, the Music Practice Browser, for representing, identifying, and analysing music practice behaviors. The Music Practice Browser provides a graphical interface for reviewing recorded practice sessions, which allows musicians, teachers, and researchers to examine aspects and features of music practice behaviors. Read More

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November 2018

Insights in Public Health: Ke A'o Mau: Strengthening Cultural Competency in Interdisciplinary Education.

Hawaii J Med Public Health 2018 Dec;77(12):333-336

Myron B. Thompson School of Social Work, University of Hawai'i at Manoa, Honolulu, HI.

In order to successfully address social determinants of health and to achieve social justice for and all the people of Hawai'i, we must broaden our understanding of and approach to healing/health through interdisciplinary, culturally-informed education. Strengthening cultural competence within an Interprofessional Education framework, has potential in meeting important challenges in patient and population health, including meeting the increased demand for culturally trained professionals, increasing access to providers, and reducing health inequities in (Native Hawaiians). We present a model of course design and delivery, (Learning Preserved), intended to provide (students) with a unique body of culturally-anchored and community-based knowledge, skills and values that facilitate work with was implemented in the 2017-2018 academic year at University of Hawai'i (UH) at Manoa and optimized the authenticity of cultural learning through the engagement of (expert teachers) to instruct in their area of expertise. Read More

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December 2018

Combination of the tubular retractor and brain spatulas provides an adequate operative field in surgery for deep-seated lesions: Case series and technical note.

Surg Neurol Int 2018 1;9:220. Epub 2018 Nov 1.

Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2-5-1 Shikata, Kita-ku, Okayama 700-8558, Japan.

Background: Surgeries for deep-seated lesions are challenging because making a corridor and observing the interface between lesions and normal brain tissue are difficult. The ViewSite Brain Access System, which is a clear plastic tubular retractor system, is used for resection of deep-seated lesions. However, the tapered shape of this system may result in limitation of the surgical field and cause brain injury to observe the interface between lesions and normal tissue. Read More

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November 2018

Modifier Ontologies for frequency, certainty, degree, and coverage phenotype modifier.

Biodivers Data J 2018 28(6):e29232. Epub 2018 Nov 28.

University of Arizona, Tucson, United States of America University of Arizona Tucson United States of America.

When phenotypic characters are described in the literature, they may be constrained or clarified with additional information such as the location or degree of expression, these terms are called "modifiers". With effort underway to convert narrative character descriptions to computable data, ontologies for such modifiers are needed. Such ontologies can also be used to guide term usage in future publications. Read More

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November 2018

Developing key performance indicators for guaranteeing right to health and access to medical service for persons with disabilities in Korea: Using a modified Delphi.

PLoS One 2018 7;13(12):e0208651. Epub 2018 Dec 7.

Department of Medical Education and Medical Humanities, Kyung Hee University School of Medicine, Dongdaemun-gu, Seoul, Korea.

Recently, the Act on Guarantee of Right to Health and Access to Medical Service for Persons with Disabilities was implemented to legally define the health care system for persons with disabilities (PWDs) and the guarantee of access to medical care in Korea. This study aimed to develop specific goals and performance indicators to establish a system to guarantee right to health and access to medical service for PWDs. The first procedure was the establishment of the performance indicators, and the second was the content validity verification of the established performance indicators. Read More

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December 2018

Non-GVHD ocular complications after hematopoietic cell transplantation: expert review from the Late Effects and Quality of Life Working Committee of the CIBMTR and Transplant Complications Working Party of the EBMT.

Bone Marrow Transplant 2018 Dec 7. Epub 2018 Dec 7.

Department of Ophthalmology, Hospital Universitario Puerta de Hierro, Madrid, Spain.

Non-graft-vs.-host disease (non-GVHD) ocular complications are generally uncommon after hematopoietic cell transplantation (HCT), but can cause prolonged morbidity affecting activities of daily living and quality of life. Here we provide an expert review of non-GVHD ocular complications in a collaboration between transplant physicians and ophthalmologists through the Late Effects and Quality of Life Working Committee of the Center for International Blood and Marrow Transplant Research and the Transplant Complications Working Party of the European Society of Blood and Marrow Transplantation. Read More

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December 2018

Ocular graft-versus-host disease after hematopoietic cell transplantation: Expert review from the Late Effects and Quality of Life Working Committee of the CIBMTR and Transplant Complications Working Party of the EBMT.

Bone Marrow Transplant 2018 Dec 7. Epub 2018 Dec 7.

Department of Ophthalmology, University Clinical Hospital Zagreb, Zagreb, Croatia.

Ocular graft-versus-host disease (GVHD) occurs in more than half of patients who develop chronic GVHD after allogeneic hematopoietic cell transplantation (HCT), causing prolonged morbidity, which affects activities of daily living and quality of life. Here we provide an expert review of ocular GVHD in a collaboration between transplant physicians and ophthalmologists through the Late Effects and Quality of Life Working Committee of the Center for International Blood and Marrow Transplant Research and the Transplant Complications Working Party of the European Society of Blood and Marrow Transplantation. Recent updates in ocular GVHD, regarding pathophysiology, preclinical models, risk factors, prevention, screening, diagnosis, response criteria, evaluation measures, and treatment are discussed in this review. Read More

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December 2018

Secondary research uses of residual newborn screening dried bloodspots: a scoping review.

Genet Med 2018 Dec 10. Epub 2018 Dec 10.

School of Medicine, Department of Ob/Gyn and Pediatrics, University of Utah, Salt Lake City, UT, USA.

Purpose: Residual newborn screening dried bloodspots (DBS) are a valuable resource for research but the extent, type, and nature of uses are unknown. The objective of this research was to systematically review the published literature about secondary research uses of residual DBS using a scoping review protocol.

Methods: A total of 654 publications meeting the inclusion criteria with a 94% interrater reliability were identified. Read More

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December 2018

Using Theory to Inform and Guide Perinatal Bereavement Care.

MCN Am J Matern Child Nurs 2019 Jan/Feb;44(1):20-26

Marianne H. Hutti is a Professor, University of Louisville, School of Nursing, Louisville, KY. The author can be reached via e-mail at Rana Limbo is Director Emeritus, Resolve Through Sharing, Gundersen Medical Foundation.

Providing nursing care to perinatally bereaved women and their families is difficult, emotionally demanding, and complicated. Here we demonstrate how, through understanding the theoretical underpinnings of Guided Participation and perinatal grief intensity, nurses can significantly expand their competence and confidence in their ability to provide highly individualized, supportive, relationship-based perinatal bereavement care. The way that parents respond to a perinatal loss may range from little response to highly intense, long-lasting grief. Read More

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December 2018

Influenza and Pregnancy: No Time for Complacency.

Obstet Gynecol 2018 Dec 4. Epub 2018 Dec 4.

University of Florida College of Medicine & College of Public Health and Health Professions, Departments of Pediatrics and Epidemiology, Gainesville, Florida; and Emory University, Department of Gynecology and Obstetrics, Atlanta, Georgia.

The 2009 H1N1 pandemic demonstrated the severe effects of influenza illness on pregnant women. This experience stimulated efforts to improve influenza vaccination coverage among pregnant women and resulted in a substantial increase in coverage from less than 30% before 2009 to more than 50% a few years later. As memories fade of the pandemic year, influenza vaccination coverage has stagnated at around 50%, despite considerable information becoming available on strategies to improve vaccination coverage during pregnancy. Read More

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December 2018

Six Lessons to Guide Intentional Career Action: Homage to the Queen of Soul and a Maverick Senator.

Prof Case Manag 2018 Dec 6. Epub 2018 Dec 6.

Ellen Fink-Samnick, MSW, ACSW, LCSW, CCM, CRP, is an award-winning, industry thought leader who empowers health care's transdisciplinary workforce through professional speaking, writing, mentoring, and consultation. A subject matter expert on Ethics, Ellen is an esteemed author with more than 100 publications to her credit. She has authored content for many of the industry's knowledge projects for case managers, including chapters on the Ethical Use of Case Management Technology, Workplace Bullying, Collaborative Care, and the Social Determinants of Health. Her contributions to professional case management, ethics, and clinical social work transverse professional associations and credentialing organizations, including roles as subject matter expert, examination item writer, and leadership positions. She is a vibrant professional voice.

Independent of political perspective or musical preferences, the deaths of two individuals who played a major role in history was worthy of a moment of pause. The life lessons inspired by the efforts of these icons, plus the work of motivational author Jon Acuff together serve to empower the intentional action of professional case managers in defining a successful career path. Read More

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December 2018

Development of a simplified Cold Intolerance Symptom Severity questionnaire in patients with peripheral nerve injury.

Int J Rehabil Res 2018 Dec 10. Epub 2018 Dec 10.

Istituti Clinici Scientifici Maugeri, IRCCS, Bioengineering Unit of Veruno Institute (NO) Italy.

The aim of this study was to analyse the Cold Intolerance Symptom Severity (CISS) questionnaire in its Italian validated version, using Rasch analysis, to gain insights for a possible refinement of the questionnaire. The CISS was administered to a convenience sample of 96 consecutively recruited outpatients with upper limb peripheral nerve injury. Data were analysed using Rasch analysis. Read More

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December 2018

Expert Commentary on Anastomotic Leak After Colonic Resection.

Dis Colon Rectum 2019 Jan;62(1):12-13

Duke University Medical Center, Durham, North Carolina.

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January 2019

The Adaption of the Client Sociodemographic and Service Receipt Inventory for Costing Mental Health Services in Brazil.

J Ment Health Policy Econ 2018 Sep;21(3):131-142

Centro de Economia em Saude Mental (CESM) Departamento de Psiquiatria, Universidade Federal de Sao Paulo (UNIFESP) Rua Borges Lagoa 570, 1 andar, Vila Clementino, Sao Paulo, 04038-000, Brazil,

Background: There is a scarcity of tested instruments for measuring mental health services and costs. The Client Sociodemographic Service Receipt Inventory (CSSRI) is the most used tool in economic evaluation in mental health in Europe; it was translated into five languages, and it was mainly used to evaluate deinstitutionalisation process in mental health system reform.

Aims Of The Study: To translate and adapt to the Brazilian healthcare system, and to test its inter-rater reliability, validity and its feasibility in a deinstitutionalized sample of psychiatric hospital living in residential facilities. Read More

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September 2018

Creation of an Enhanced Recovery After Surgery (ERAS) Guideline for neonatal intestinal surgery patients: a knowledge synthesis and consensus generation approach and protocol study.

BMJ Open 2018 Dec 9;8(12):e023651. Epub 2018 Dec 9.

Department of Surgery, Alberta Children's Hospital, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

Introduction: Enhanced Recovery After Surgery (ERAS) guidelines integrate evidence-based practices into multimodal care pathways designed to optimise patient recovery following surgery. The objective of this project is to create an ERAS protocol for neonatal abdominal surgery. The protocol will identify and attempt to bridge the gaps between current practices and best evidence. Read More

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December 2018

Evidence synthesis, practice guidelines and real-world prescriptions of new generation antidepressants in the treatment of depression: a protocol for cumulative network meta-analyses and meta-epidemiological study.

BMJ Open 2018 Dec 9;8(12):e023222. Epub 2018 Dec 9.

Department of Health Promotion and Human Behavior, School of Public Health in the Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Introduction: Depressive disorders are the most common, burdensome and costly mental disorders. Their treatments have developed through the past decades and we now have more than a dozen new generation antidepressants, while a series of guidelines have been published to provide recommendations over the years. However, there still may exist important gaps in this evidence synthesis and implementation process. Read More

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December 2018

The evolution of hazardous drug safety: Thirty-five years of protecting healthcare personnel.

Am J Health Syst Pharm 2018 Dec;75(24):1970-1971

Assistant Vice President, Drug Information.

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December 2018

Deep Learning in Cardiology.

IEEE Rev Biomed Eng 2018 Dec 10. Epub 2018 Dec 10.

The medical field is creating large amount of data that physicians are unable to comprehend and use efficiently. Moreover, rule-based expert systems are inefficient in solving complicated medical tasks or creating insights using big data. Deep learning has emerged as a more accurate and effective technology in a wide range of medical problems such as diagnosis, prediction and intervention. Read More

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December 2018

Evaluating the hip-flask defence in subjects with alcohol on board: An experimental study.

Forensic Sci Int 2018 Nov 26;294:189-195. Epub 2018 Nov 26.

Department of Forensic Genetics and Forensic Toxicology, National Board of Forensic Medicine, Linköping, Sweden; Division of Drug Research, Department of Medical and Health Sciences, Linköping University, Linköping, Sweden. Electronic address:

Driving under the influence of alcohol is a major problem for traffic-safety and a popular defence argument is alleged consumption after driving, commonly referred to as the hip-flask defence. Forensic toxicologists are often called as expert witnesses in drinking and driving cases where the suspect has claimed the hip-flask defence, to assess the credibility of the explanation. Several approaches to help the expert have been introduced but the scientific data used to support or challenge this is solely based on data from controlled single doses of ethanol administered during a short time and in abstinent subjects. Read More

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November 2018

Experimental Ethology of Learning in Desert Ants: Becoming Expert Navigators.

Behav Processes 2018 Dec 5. Epub 2018 Dec 5.

Department of Biological Sciences, Macquarie University, Sydney, Australia.

Foraging desert ants are repeatedly presented with the challenge of leaving the nest, searching the scorching desert landscape to find food, and then transporting it back home. To accomplish this task, foragers have a navigational toolbox, which relies on olfactory, idiothetic, visual and magnetic cues. Desert ants have been widely studied with regards to these abilities, including a heavy focus on learned visual cues, the most prominent being the terrestrial panorama. Read More

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December 2018

Efficacy of the cardiac septal occluder in the treatment of post-bariatric surgery leaks and fistulas.

Gastrointest Endosc 2018 Dec 6. Epub 2018 Dec 6.

Brigham and Women's Hospital - Harvard Medical School - USA. Electronic address:

Introduction: Endoscopy has evolved to become first-line therapy for the treatment of post-bariatric leaks; however, many sessions are often required with variable success rates. Due to these limitations, the use of the cardiac septal defect occluder (CSDO) has recently been reported in this population.

Methods: This is a multicenter retrospective series in patients with post-bariatric surgical leaks who underwent treatment with CSDO placement. Read More

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December 2018

Threshold of Metabolic Acidosis Associated with Newborn Cerebral Palsy: Medical Legal Implications.

Authors:
Michael G Ross

Am J Obstet Gynecol 2018 Dec 6. Epub 2018 Dec 6.

Los Angeles, California, Department of Obstetrics and Gynecology, Geffen School of Medicine at UCLA. Electronic address:

Obstetricians and gynecologists belong to one of the medical specialties with the highest rate of litigation claims. Among birth injury cases, those with cerebral palsy outcomes account for litigation settlements or judgements often in the millions of dollars. In cases of potential perinatal asphyxia, a threshold level of metabolic acidosis (base deficit (BD) >12 mmol/l) is necessary to attribute neonatal encephalopathy to an intrapartum hypoxic event. Read More

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December 2018

Software-assisted manual review of clinical next-generation sequencing data An alternative to routine Sanger sequencing confirmation with equivalent results in >15,000 germline DNA screens.

J Mol Diagn 2018 Dec 4. Epub 2018 Dec 4.

Counsyl, Inc., South San Francisco, Califormia.

Clinical genomic tests increasingly utilize a next-generation sequencing (NGS) platform due in part to the high fidelity of variant calls, yet rare errors are still possible. In germline DNA screening, failure to correct such errors could have serious consequences for patients, who may follow an unwarranted screening or surgical-management path. It has been suggested that routine orthogonal confirmation via Sanger sequencing is required to verify NGS results, especially low-confidence positives with depressed allele fraction (<30% of alternate allele). Read More

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December 2018

Identification of a robust methylation classifier for cutaneous melanoma diagnosis.

J Invest Dermatol 2018 Dec 6. Epub 2018 Dec 6.

Department of Dermatology, School of Medicine, University of North Carolina, Chapel Hill, NC; Lineberger Comprehensive Cancer Center (LCCC), University of North Carolina at Chapel Hill, Chapel Hill, NC.

Early diagnosis improves melanoma survival, yet the histopathological diagnosis of cutaneous primary melanoma can be challenging even for expert dermatopathologists. Analysis of epigenetic alterations, such as DNA methylation, that occur in melanoma can aid in its early diagnosis. Using a genome-wide methylation screen, we assessed CpG methylation in a diverse set of 89 primary invasive melanomas, 73 nevi, and 41 melanocytic proliferations of uncertain malignant potential, classified based on interobserver review by dermatopathologists. Read More

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December 2018

Sensory quality control of dry-cured ham: A comprehensive methodology for sensory panel qualification and method validation.

Meat Sci 2018 Nov 29;149:149-155. Epub 2018 Nov 29.

Department of Analytical Chemistry, University of Granada, c/ Fuentenueva, s.n. E-18071 Granada, Spain.

In this study, a specific sensory panel was created and qualified for sensory assessment of Spanish dry-cured ham. A strict control was carried out in order to recruit, select, train and qualify the assessors. At the beginning, 29 candidates to assessors were considered and at the end only 9 candidates satisfied the conditions required to be qualified as expert assessors of the sensory panel. Read More

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November 2018

The impact of transmission dynamics of rabies control: Systematic review.

Vaccine 2018 Dec 5. Epub 2018 Dec 5.

Health Technology Assessment Postgraduate Program, Mahidol University, 447 Sri-Ayuthaya Road, Phaya Thai, Ratchathewi, Bangkok 10400, Thailand; Department of Epidemiology, Faculty of Public Health, Mahidol University, 420/1 Ratchawithi Road, Phaya Thai, Ratchathewi, Bangkok 10400, Thailand. Electronic address:

The public health and economic burden of rabies has led to major intersectoral initiatives worldwide to reduce its burden. Over the last decade, the impact of rabies prevention and control programmes in real-world settings has become increasingly evident, especially in countries where most rabies exposures and deaths occur, but they have yet to successfully eradicate rabies due to limited access to health care services. We aimed to systematically review published transmission dynamic modelling studies of rabies in both humans and dogs with a focus on studies which estimated the epidemiological and economic impact of different preventive measures. Read More

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December 2018

Psychometric evaluation of a patient-reported outcome measure in pancreatic exocrine insufficiency (PEI).

Pancreatology 2018 Nov 27. Epub 2018 Nov 27.

University Medicine Greifswald, Greifswald, Germany.

Background/objectives: Pancreatic exocrine insufficiency (PEI) is commonly caused by chronic pancreatitis (CP) or cystic fibrosis (CF). There are no PEI-specific patient-reported assessments of symptoms and impacts. The PEI Questionnaire (PEI-Q) was developed through qualitative research with PEI patients and expert clinical input. Read More

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November 2018
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