1,524 results match your criteria Expert Opinion on Drug Delivery[Journal]


Blood-brain barrier receptors and transporters: an insight on their function and how to exploit them through nanotechnology.

Expert Opin Drug Deliv 2019 Feb 15. Epub 2019 Feb 15.

a CESPU - Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde , Rua Central de Gandra 1317, 4585-116 Gandra , Portugal.

Introduction: The blood-brain barrier (BBB) is a highly limiting barrier that prevents the brain from contacting with several circulating molecules, including harmful agents. However, certain systemic nutrients and macromolecules are able to cross the BBB and reach the brain parenchyma, involving the interaction with multiple receptors and/or transporters at BBB surface. Nanotechnology allows the creation of drug vehicles, functionalized with targeting ligands for binding specific BBB receptors and/or transporters, hence triggering the transport through this biobarrier. Read More

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http://dx.doi.org/10.1080/17425247.2019.1583205DOI Listing
February 2019

Multi-functional chitosan-based smart hydrogels mediated biomedical application.

Expert Opin Drug Deliv 2019 Feb 12. Epub 2019 Feb 12.

a State Key Laboratory of Biotherapy and Cancer Center , West China Hospital, Sichuan University , R. P. China.

Introduction: Chitosan as a natural polysaccharide have been widely applied in biomedicine due to their outstanding biodegradability, non-toxic, and low-price. As carriers, the multi-functional chitosan hydrogels can be prepared by physical and chemical modification to form smart hydrogels to release cargoes. The smart hydrogels can generate sol-gel phase transition while gaining stimulus from environment including pH, temperature, photo and so forth. Read More

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http://dx.doi.org/10.1080/17425247.2019.1580691DOI Listing
February 2019

Cell membrane capsule: a novel natural tool for antitumour drug delivery.

Expert Opin Drug Deliv 2019 Feb 11. Epub 2019 Feb 11.

c Department of Hepatobiliary Surgery , Zhejiang Provincial People's Hospital , Hangzhou 310000 , China.

Introduction: Chemotherapy plays an important role in antitumour therapy, but causes serious adverse reactions. So, drug delivery system (DDS) with cell-targeting ability is an important method to reduce adverse reactions while ensuring the effectiveness of chemotherapy. Synthetic drug carriers and DDSs based on cells have proven safety and efficacy, but they also have many deficiencies or limitations. Read More

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http://dx.doi.org/10.1080/17425247.2019.1581762DOI Listing
February 2019

Novel cystamine-core dendrimer-formulation rescues ΔF508-CFTR and inhibits Pseudomonas aeruginosa infection by augmenting autophagy.

Expert Opin Drug Deliv 2019 Feb 7;16(2):177-186. Epub 2019 Feb 7.

a College of Medicine , Central Michigan University , Mt Pleasant , MI , USA.

Background: Cystic fibrosis (CF) is challenged with pathophysiological barriers for effective airway drug-delivery. Hence, we standardized the therapeutic efficacy of the novel dendrimer-based autophagy-inducing anti-oxidant drug, cysteamine.

Research Design And Methods: Human primary-CF epithelial-cells, CFBE41o-cells were used to standardize the efficacy of the dendrimer-cystamine in correcting impaired-autophagy, rescuing ΔF508-CFTR and Pseudomonas-aeruginosa (Pa) infection. Read More

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http://dx.doi.org/10.1080/17425247.2019.1575807DOI Listing
February 2019
1 Read

An exploration of aptamer internalization mechanisms and their applications in drug delivery.

Expert Opin Drug Deliv 2019 Jan 28:1-12. Epub 2019 Jan 28.

a The People's Hospital , China Three Gorges University , Yichang , China.

Introduction: As 'chemical antibodies', aptamers have some advantages, such as lack of immunogenicity, rapid tissue penetration, cell internalization and so on. Consequently, more and more aptamers have been screened out by the systematic evolution of ligands through exponential enrichment for the desired cells or membrane receptors. On the basis of the result, researchers use aptamers to guide drug targeting to the desired cells and internalization in vivo. Read More

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http://dx.doi.org/10.1080/17425247.2019.1575808DOI Listing
January 2019

Mesoporous silica nanoparticles: synthesis, classification, drug loading, pharmacokinetics, biocompatibility, and application in drug delivery.

Expert Opin Drug Deliv 2019 Jan 28:1-19. Epub 2019 Jan 28.

a Department of Pharmaceutical Sciences , Shanghai University of Traditional Chinese Medicine , Shanghai , China.

Introduction: Mesoporous silica nanoparticles (MSNs) feature a high surface area and large pore volume, uniform and tunable pore size, and stable framework; thus, they have been used extensively as drug carriers. Areas covered: The synthesis, classification, and the latest generation of MSNs, drug loading methods, modification of MSNs, pharmacokinetic studies, biocompatibility, and toxicity of MSNs, and their application in drug delivery systems (DDS) are covered in this review. Expert opinion: It is crucial to uncover the mechanism for the formation of MSNs. Read More

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http://dx.doi.org/10.1080/17425247.2019.1575806DOI Listing
January 2019

Development challenges and opportunities in aerosol drug delivery systems in non-invasive ventilation in adults.

Expert Opin Drug Deliv 2019 Feb 30;16(2):153-162. Epub 2019 Jan 30.

a Institut de Recherche Expérimentale et Clinique (IREC), Pôle de Pneumologie, ORL & Dermatologie , Université Catholique de Louvain , Bruxelles , Belgium.

Introduction: With the gain in popularity of non-invasive ventilation (NIV), particularly in patients requiring drug delivery by aerosol therapy, the feasibility of the combination between NIV and aerosol therapy has regularly been questioned. Areas covered: This review covers the in vitro and in vivo studies which explored the effects of this combination on pulmonary drug delivery (imaging and pharmacological studies) and on physiological measurements. Expert opinion: Even if the feasibility of the combination is evident, the type of nebulizer influences the lung deposition with a greater delivery with vibrating mesh nebulizers. Read More

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http://dx.doi.org/10.1080/17425247.2019.1572111DOI Listing
February 2019
2 Reads

The burden of at-home preparation of lyophilized parenteral medications: an analysis of contributing factors and implications for chronic disease patients and caregivers.

Expert Opin Drug Deliv 2019 Jan 13:1-12. Epub 2019 Jan 13.

a Matchstick , Boonton , NJ , USA.

Background: In the acute care setting, parenteral medication errors are well-studied. However, there is comparatively little research on how these issues translate to patient- or caregiver-prepared medications in the home, particularly with reconstituted medications.

Methods: This was an ethnographic study designed to identify issues associated with four reconstitution use scenarios. Read More

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http://dx.doi.org/10.1080/17425247.2019.1569626DOI Listing
January 2019

Subcutaneous delivery of biotherapeutics: challenges at the injection site.

Expert Opin Drug Deliv 2019 Feb 24;16(2):143-151. Epub 2019 Jan 24.

a Department of Pharmaceutical Technology, Faculty of Pharmacy , University of Coimbra , Coimbra , Portugal.

Introduction: Biotherapeutics are primarily delivered subcutaneously due to better compliance and prolonged rate of absorption compared to other parenteral administration routes. Recent research has allowed for the development of biotherapeutic formulations for subcutaneous delivery that require a lower frequency of administration by increasing drug half-life. Formulations determine shelf-life stability as well as features and transient behaviors that influence stability once implanted in the subcutaneous space. Read More

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http://dx.doi.org/10.1080/17425247.2019.1568408DOI Listing
February 2019
2 Reads

Evaluating the safety profile of focused ultrasound and microbubble-mediated treatments to increase blood-brain barrier permeability.

Expert Opin Drug Deliv 2019 Feb 29;16(2):129-142. Epub 2019 Jan 29.

a Physical Sciences Platform , Sunnybrook Research Institute , Toronto , ON , Canada.

Introduction: Treatment of several diseases of the brain are complicated by the presence of the skull and the blood-brain barrier (BBB). Focused ultrasound (FUS) and microbubble (MB)-mediated BBB treatment is a minimally invasive method to transiently increase the permeability of blood vessels in targeted brain areas. It can be used as a general delivery system to increase the concentration of therapeutic agents in the brain parenchyma. Read More

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http://dx.doi.org/10.1080/17425247.2019.1567490DOI Listing
February 2019
1 Read

Actinic keratosis and imiquimod: a review of novel carriers and patents.

Expert Opin Drug Deliv 2019 Feb 24;16(2):101-112. Epub 2018 Dec 24.

a UGC Centre of Advanced Studies , University Institute of Pharmaceutical Sciences, Panjab University , Chandigarh , India.

Introduction: Actinic keratosis is one of the most common disorder characterized by erythematic and generally attached scaly lesions which are present either alone or in clusters. World Health Organization defines actinic keratosis as a common intraepidermal neoplasm of sun-damaged skin, characterized by variable atypia of keratinocytes. Area covered: At the beginning of the 20th century, a new immunomodulator molecule, imiquimod, appears in the market for the treatment of actinic keratosis but suffers from the pitfalls of the conventional approach of dosage form preparation including high dose, poor stability and more side effects. Read More

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http://dx.doi.org/10.1080/17425247.2019.1560418DOI Listing
February 2019
1 Read

Toward a new age of patient centricity? The application of eye-tracking to the development of connected self-injection systems.

Expert Opin Drug Deliv 2019 Feb 9;16(2):163-175. Epub 2019 Jan 9.

a Product Development Group Zurich, Department of Mechanical and Process Engineering , ETH Zurich , Zurich , Switzerland.

Background: Increasing interest in digitally enhanced drug delivery tools urges both industry and academia to rethink current approaches to product usability testing. This article introduces mobile eye-tracking, generating detailed contextual data about user engagement with connected self-injection systems as a new methodological approach to formative usability assessment.

Methods: A longitudinal case study with a total of 35 injection-naïve participants was conducted. Read More

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http://dx.doi.org/10.1080/17425247.2019.1563070DOI Listing
February 2019

Nanotheranostics, a future remedy of neurological disorders.

Expert Opin Drug Deliv 2019 Feb 7;16(2):113-128. Epub 2019 Jan 7.

a Institute of Nano Science and Technology , Mohali , India.

Introduction: Effective therapy of various neurological disorders is hindered on account of the failure of various therapeutics crossing blood-brain-barrier (BBB). Nanotheranostics has emerged as a cutting-edge unconventional theranostic nanomedicine, capable of realizing accurate diagnosis together with effective and targeted delivery of therapeutics across BBB to the unhealthy regions of the brain for potential clinical success. Areas covered: We have tried to review the current status of nanotheranostic based approaches followed to manage neurological disorders. Read More

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https://www.tandfonline.com/doi/full/10.1080/17425247.2019.1
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http://dx.doi.org/10.1080/17425247.2019.1562443DOI Listing
February 2019
5 Reads

The prodrug approach in the era of drug design.

Expert Opin Drug Deliv 2018 Dec 18:1-5. Epub 2018 Dec 18.

a Department of Bioorganic & Pharmaceutical Chemistry, Faculty of Pharmacy , Al-Quds University , Jerusalem , Palestine.

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http://dx.doi.org/10.1080/17425247.2019.1553954DOI Listing
December 2018
4.840 Impact Factor

Stimuli-responsive graphene-incorporated multifunctional chitosan for drug delivery applications: a review.

Expert Opin Drug Deliv 2018 Dec 4. Epub 2018 Dec 4.

b Nanotechnology Department , School of New Technologies, Iran University of Science and Technology (IUST) , Tehran , Iran.

Introduction: Recently, the use of chitosan (CS) in the drug delivery has reached an acceptable maturity. Graphene-based drug delivery is also increasing rapidly due to its unique physical, mechanical, chemical and electrical properties. Therefore, the combination of CS and graphene can provide a promising carrier for the loading and controlled release of therapeutic agents. Read More

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http://dx.doi.org/10.1080/17425247.2019.1556257DOI Listing
December 2018
1 Read

Magnetic iron oxide nanoparticles for drug delivery: applications and characteristics.

Expert Opin Drug Deliv 2019 Jan 9;16(1):69-78. Epub 2018 Dec 9.

a Department of General, Organic and Biomedical Chemistry, NMR and Molecular Imaging Laboratory , University of Mons , Mons , Belgium.

Introduction: For many years, the controlled delivery of therapeutic compounds has been a matter of great interest in the field of nanomedicine. Among the wide amount of drug nanocarriers, magnetic iron oxide nanoparticles (IONs) stand out from the crowd and constitute robust nanoplatforms since they can achieve high drug loading as well as targeting abilities stemming from their remarkable properties (magnetic and biological properties). These applications require precise design of the nanoparticles regarding several parameters which must be considered together in order to attain highest therapeutic efficacy. Read More

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https://www.tandfonline.com/doi/full/10.1080/17425247.2019.1
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http://dx.doi.org/10.1080/17425247.2019.1554647DOI Listing
January 2019
14 Reads

Strategies for modifying drug residence time and ocular bioavailability to decrease treatment frequency for back of the eye diseases.

Expert Opin Drug Deliv 2018 Nov 29. Epub 2018 Nov 29.

b School of Pharmaceutical Sciences, University of Geneva & University of Lausanne , CMU - 1 rue Michel Servet, 1211 Geneva 4, Switzerland.

Introduction: Treating posterior eye diseases has become a major area of focus for pharmaceutical and biotechnology companies. Current standard of care for treating posterior eye diseases relies on administration via intravitreal injection. Although effective, this is not without complications and there is great incentive to develop longer-acting therapeutics and/or sustained release delivery systems. Read More

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http://dx.doi.org/10.1080/17425247.2019.1553953DOI Listing
November 2018
1 Read

Future of nanomedicines for treating respiratory diseases.

Expert Opin Drug Deliv 2019 Jan 4;16(1):59-68. Epub 2018 Dec 4.

a Department of Pharmaceutics and Biopharmaceutics , Kiel University , Kiel , Germany.

Introduction: Nanoparticles are under discussion in drug delivery for more than 20 years now, but examples for nanoparticulate formulations in the treatment of respiratory diseases are rare and mostly limited to the administration of sub-micron drug particles (ultrafine particles). However, nanoparticles may also carry specific benefits for respiratory treatment. Are nanoparticles the next-generation drug carrier system to facilitate systemic delivery, sustained release and cancer treatment in the lungs? Areas covered: This review will look into the promises and opportunities of the use of nanoparticles in the treatment of respiratory diseases. Read More

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http://dx.doi.org/10.1080/17425247.2019.1553955DOI Listing
January 2019

Use of computational fluid dynamics deposition modeling in respiratory drug delivery.

Expert Opin Drug Deliv 2018 Nov 21. Epub 2018 Nov 21.

b Department of Pharmaceutics , Virginia Commonwealth University , Richmond , VA , USA.

Introduction: Respiratory drug delivery is a surprisingly complex process with a number of physical and biological challenges. Computational fluid dynamics (CFD) is a scientific simulation technique that is capable of providing spatially and temporally resolved predictions of many aspects related to respiratory drug delivery from initial aerosol formation through respiratory cellular drug absorption. Areas Covered: This review article focuses on CFD-based deposition modeling applied to pharmaceutical aerosols. Read More

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http://dx.doi.org/10.1080/17425247.2019.1551875DOI Listing
November 2018
14 Reads

Yeast-inspired drug delivery: biotechnology meets bioengineering and synthetic biology.

Expert Opin Drug Deliv 2018 Nov 21. Epub 2018 Nov 21.

a College of Pharmaceutical Sciences, Govt. Medical College , Kozhikode - 673008 , Kerala , India .

Introduction: Yeast-based drug delivery offers a promising platform for the treatment of various medical conditions. Even the most promising nanoparticulate delivery systems have challenges from gastrointestinal barriers. The novel approach using bio-inspired yeast microcapsule helps in the delivery of charged nanoparticles like quantum dots, iron oxide nanoparticle and various fluorescent nanoparticles. Read More

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http://dx.doi.org/10.1080/17425247.2019.1551874DOI Listing
November 2018
9 Reads

Lung cancer: active therapeutic targeting and inhalational nanoproduct design.

Expert Opin Drug Deliv 2018 Nov 13:1-25. Epub 2018 Nov 13.

e Dipartimento di Farmacia , Università degli Studi di Parma , Parma , Italy.

Introduction: Pulmonary drug delivery is organ-specific and benefits local drug action for lung cancer. The use of nanotechnology and targeting ligand enables cellular-specific drug action. Combination approaches increase therapeutic efficacy and reduce adverse effects of cancer chemotherapeutics that have narrow therapeutic index window and high cytotoxicity levels. Read More

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https://www.tandfonline.com/doi/full/10.1080/17425247.2018.1
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http://dx.doi.org/10.1080/17425247.2018.1547280DOI Listing
November 2018
18 Reads
4.840 Impact Factor

Pre-filled syringes for immunoglobulin G (IgG) replacement therapy: clinical experience from other disease settings.

Expert Opin Drug Deliv 2018 Nov 13. Epub 2018 Nov 13.

c Infectious Disease Susceptibility Program , Research Institute - McGill University Health Centre , Montreal , Quebec , Canada.

Introduction: Ready-to-use pre-filled syringes for drug delivery are increasingly used across a broad spectrum of clinical specialties. For patients with primary immunodeficiencies manifesting as antibody deficiencies, immunoglobulin G (IgG) replacement therapy (IgRT) by subcutaneous administration is an established treatment modality. Expanding IgRT administration options through the introduction of pre-filled syringes may further improve its utility. Read More

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https://www.tandfonline.com/doi/full/10.1080/17425247.2018.1
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http://dx.doi.org/10.1080/17425247.2018.1546692DOI Listing
November 2018
5 Reads

Characterization of drug delivery vehicles using atomic force microscopy: current status.

Expert Opin Drug Deliv 2018 Nov 10:1-11. Epub 2018 Nov 10.

c School of Pharmacy , Queen's University Belfast , Belfast , UK.

Introduction: The field of nanomedicine, utilizing nano-sized vehicles (nanoparticles and nanofibers) for targeted local drug delivery, has a promising future. This is dependent on the ability to analyze the chemical and physical properties of these drug carriers at the nanoscale and hence atomic force microscopy (AFM), a high-resolution imaging and local force-measurement technique, is ideally suited. Areas covered: Following a brief introduction to the technique, the review describes how AFM has been used in selected publications from 2015 to 2018 to characterize nanoparticles and nanofibers as drug delivery vehicles. Read More

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https://www.tandfonline.com/doi/full/10.1080/17425247.2018.1
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http://dx.doi.org/10.1080/17425247.2018.1546693DOI Listing
November 2018
7 Reads

Sonopermeation to improve drug delivery to tumors: from fundamental understanding to clinical translation.

Expert Opin Drug Deliv 2018 Nov 12:1-13. Epub 2018 Nov 12.

e Department of Pharmaceutics , Utrecht University , Utrecht , The Netherlands.

Introduction: Ultrasound in combination with microbubbles can make cells and tissues more accessible for drugs, thereby achieving improved therapeutic outcomes. In this review, we introduce the term 'sonopermeation', covering mechanisms such as pore formation (traditional sonoporation), as well as the opening of intercellular junctions, stimulated endocytosis/transcytosis, improved blood vessel perfusion and changes in the (tumor) microenvironment. Sonopermeation has gained a lot of interest in recent years, especially for delivering drugs through the otherwise impermeable blood-brain barrier, but also to tumors. Read More

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http://dx.doi.org/10.1080/17425247.2018.1547279DOI Listing
November 2018
1 Read

Novel nicotinamide skin-adhesive hot melt extrudates for treatment of acne.

Expert Opin Drug Deliv 2018 Nov 9:1-9. Epub 2018 Nov 9.

a Centre for Pharmaceutical Engineering Science , University of Bradford , Bradford , UK.

Objectives: Hot melt extrusion is a continuous process with wide industrial applicability. Till current date, there have been no reports on the formulation of extrudates for topical treatment of dermatological diseases.

Methods: The aim of the present work was to prepare and characterize medicated hot melt extrudates based on Soluplus polymer and nicotinamide, and to explore their applicability in acne treatment. Read More

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http://dx.doi.org/10.1080/17425247.2018.1546287DOI Listing
November 2018
3 Reads

QuilliChew extended-release chewable tablets for the treatment of ADHD in patients ages 6 years old and above.

Expert Opin Drug Deliv 2018 Nov 7:1-8. Epub 2018 Nov 7.

c Department of Child/Adolescent Psychiatry , New York University School of Medicine , New York , NY , USA.

Introduction: Attention-deficit/hyperactivity disorder (ADHD) is a common neurobehavioral disorder affecting as many as 6.4 million children and adolescents in the United States. Since amphetamine (AMPH) and methylphenidate (MPH) were found to be effective more than 60 years ago, numerous formulations of these compounds have been developed. Read More

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http://dx.doi.org/10.1080/17425247.2018.1545759DOI Listing
November 2018
7 Reads

Changing the pill: developments toward the promise of an ultra-long-acting gastroretentive dosage form.

Expert Opin Drug Deliv 2018 Dec 13;15(12):1189-1198. Epub 2018 Nov 13.

a Lyndra Inc , Watertown , MA , USA.

Introduction: The development of oral sustained release dosage forms has been a longstanding goal due to the potential for ease of administration, improved pharmacokinetics, reduced dosing frequency, and improved adherence. The benefits of multiday single-dose drug delivery are evident in the success and patient adoption of injected and implanted dosage forms. However, in the space of oral medications, all current commercially available gastric resident dosage forms, and most in development, are limited to gastric residence of less than 1 day. Read More

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http://dx.doi.org/10.1080/17425247.2018.1544615DOI Listing
December 2018
9 Reads
4.840 Impact Factor

Models of deposition, pharmacokinetics, and intersubject variability in respiratory drug delivery.

Expert Opin Drug Deliv 2018 Dec 14;15(12):1175-1188. Epub 2018 Nov 14.

a Department of Mechanical Engineering , University of Alberta , Edmonton , AB , Canada.

Introduction: Aerosol drug delivery to the lungs via inhalation is widely used in the treatment of respiratory diseases. The deposition pattern of inhaled particles within the airways of the respiratory tract is key in determining the initial delivered dose. Thereafter, dose-dependent processes including drug release or dissolution, clearance, and absorption influence local and systemic exposure to inhaled drugs over time. Read More

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http://dx.doi.org/10.1080/17425247.2018.1544616DOI Listing
December 2018

Delivery of amitriptyline by intravenous and intraperitoneal administration compared in the same animal by whole-body mass spectrometry imaging of a stable isotope labelled drug substance in mice.

Expert Opin Drug Deliv 2018 Oct 25:1-7. Epub 2018 Oct 25.

b Department of Pharmacy, Faculty of Health and Medical Sciences , University of Copenhagen , Copenhagen , Denmark.

Background: The distribution and metabolism of a drug in the organism are dependent on the administration route as well as on the drug formulation. It is important to be able to assess which impact the administration route or formulation of a drug has for its distribution and metabolism.

Methods: The antidepressant drug amitriptyline was intravenously (IV) dosed to a mouse and immediately after, a similar amount of a deuterium-labeled version of the drug was intraperitoneally (IP) dosed to the same animal. Read More

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http://dx.doi.org/10.1080/17425247.2018.1541084DOI Listing
October 2018
1 Read

One-step solid-oil-water emulsion for sustained bioactive ranibizumab release.

Expert Opin Drug Deliv 2018 Oct 25:1-14. Epub 2018 Oct 25.

a Institute for Health Technologies, Interdisciplinary Graduate School , Nanyang Technological University , Singapore , Singapore.

Background: The advent of therapeutic proteins highlights the need for delivery systems that protect and extend the duration of its action. Ranibizumab-VEGF is one such drug used for treating wet AMD. This paper describes a facile method to sustain bioactive ranibizumab release from PLGA-based particles. Read More

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http://dx.doi.org/10.1080/17425247.2018.1538209DOI Listing
October 2018
4.840 Impact Factor

Overcoming multiple drug resistance in cancer using polymeric micelles.

Expert Opin Drug Deliv 2018 Nov 25;15(11):1127-1142. Epub 2018 Oct 25.

b Department of Pharmaceutics , National Institute of Pharmaceutical Education and Research (NIPER) , Mohali , India.

Introduction: A major concern that limits the success of cancer chemotherapy is multidrug resistance (MDR). The drug resistance mechanisms are either host related or tumor related. The host tumor interacting factors also contribute to MDR. Read More

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http://dx.doi.org/10.1080/17425247.2018.1537261DOI Listing
November 2018
7 Reads

Nanoparticles in detection and treatment of lymph node metastases: an update from the point of view of administration routes.

Expert Opin Drug Deliv 2018 Nov 21;15(11):1117-1126. Epub 2018 Oct 21.

b Department of Chemistry and Pharmacy , University of Sassari , Sassari , Italy.

Introduction: Lymphatic vessels are the preferential route of most solid tumors to spread their metastases in the body. Therefore, the individuation and elimination of cancer cells within the lymphatic system (LS) is an important goal. Nanoparticles (NPs), thanks to their small size, represent suitable carriers for imaging and for chemotherapeutic transport to the LS. Read More

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https://www.tandfonline.com/doi/full/10.1080/17425247.2018.1
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http://dx.doi.org/10.1080/17425247.2018.1537260DOI Listing
November 2018
7 Reads

Structural and in vitro in vivo evaluation for taste masking.

Expert Opin Drug Deliv 2018 Nov 17;15(11):1105-1116. Epub 2018 Oct 17.

a Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy , Damascus University , Syria.

Introduction: Although many techniques, such as complexation and microencapsulation, are used to mask the unpleasant taste of drugs, the success of all masking processes is evaluated in the same way. To evaluate the success of a masking process, a masked formulation must pass two tests: a structural test and an in vitro in vivo test. Areas covered: This review article highlights structural evaluation and in vitro in vivo evaluation of a taste-masking process. Read More

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https://www.tandfonline.com/doi/full/10.1080/17425247.2018.1
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http://dx.doi.org/10.1080/17425247.2018.1535590DOI Listing
November 2018
4 Reads

Targeted delivery of doxorubicin to cancer cells by a cruciform DNA nanostructure composed of AS1411 and FOXM1 aptamers.

Expert Opin Drug Deliv 2018 Nov 5;15(11):1045-1052. Epub 2018 Oct 5.

d Targeted Drug Delivery Research Center, Pharmaceutical Technology Institute , Mashhad University of Medical Sciences , Mashhad , Iran.

Objectives: Here, a novel cruciform DNA nanostructure was developed for targeted delivery of doxorubicin (Dox), as an anticancer agent, to lung (A549 cells) and breast (4T1 cells) cancer cells. The cruciform DNA nanostructure consisted of AS1411 aptamer as targeting agent and Forkhead Box Protein M1(FOXM1) aptamer as therapeutic agent.

Methods: MTT assay, fluorescence imaging, flow cytometry analysis, and in vivoantitumor efficacy were performed to evaluate the function of the Dox-DNA nanostructure complex. Read More

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http://dx.doi.org/10.1080/17425247.2018.1530656DOI Listing
November 2018
1 Read

Engineered titanium implants for localized drug delivery: recent advances and perspectives of Titania nanotubes arrays.

Expert Opin Drug Deliv 2018 Oct;15(10):1021-1037

a School of Chemical Engineering , The University of Adelaide , Adelaide , Australia.

Introduction: Therapeutics delivery to bones to treat skeletal diseases or prevent postsurgical infections is challenging due to complex and solid bone structure that limits blood supply and diffusion of therapeutics administered by systemic routes to reach effective concentration. Titanium (Ti) and their alloys are employed as mainstream implant materials in orthopedics and dentistry; having superior mechanical/biocompatibility properties which could provide an alternative solution to address this problem. Areas covered: This review presents an overview of recent development of Ti drug-releasing implants, with emphasis on nanoengineered Titania nanotubes (TNTs) structures, for solving key problems to improve implants osseointegration, overcome inflammation and infection together with providing localized drug delivery (LDD) for bone diseases including cancer. Read More

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http://dx.doi.org/10.1080/17425247.2018.1517743DOI Listing
October 2018
5 Reads

Amphiphilic block copolymers in drug delivery: advances in formulation structure and performance.

Expert Opin Drug Deliv 2018 Nov 8;15(11):1085-1104. Epub 2018 Oct 8.

a Department of Chemical and Biological Engineering , University at Buffalo, The State University of New York (SUNY) , Buffalo , NY , USA.

Introduction: Nanostructured delivery vehicles can address key challenges facing drug delivery, including the lipophilic nature of therapeutic compounds and their effective transport through the body. Amphiphilic block copolymers that self-assemble offer advantages compared with homopolymer-, lipid-, and protein-based delivery vehicles. Poly(ethylene oxide)-poly(propylene oxide) amphiphilic block copolymers (Poloxamers) serve well as pharmaceutical excipients because of their highly tunable association properties, low toxicity, and ability to functionalize. Read More

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http://dx.doi.org/10.1080/17425247.2018.1529756DOI Listing
November 2018
11 Reads

Bioresponsive polyplexes - chemically programmed for nucleic acid delivery.

Expert Opin Drug Deliv 2018 Nov 5;15(11):1067-1083. Epub 2018 Oct 5.

a Pharmaceutical Biotechnology, Department of Pharmacy , Ludwig-Maximilians-Universität , Munich , Germany.

Introduction: The whole delivery process of nucleic acids is very challenging. Appropriate carrier systems are needed, which show extracellular stability and intracellular disassembly. Viruses have developed various strategies to meet these requirements, as they are optimized by biological evolution to transfer genetic information into host cells. Read More

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http://dx.doi.org/10.1080/17425247.2018.1526922DOI Listing
November 2018
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RNAi-based therapeutics for lung cancer: biomarkers, microRNAs, and nanocarriers.

Expert Opin Drug Deliv 2018 Oct 21;15(10):965-982. Epub 2018 Sep 21.

a Department of Pharmaceutical Technology, Faculty of Pharmacy , University of Coimbra , Coimbra , Portugal.

Introduction: Despite the current advances in the discovery of the lung cancer biomarkers and, consequently, in the diagnosis, this pathology continues to be the primary cause of cancer-related death worldwide. In most cases, the illness is diagnosed in an advanced stage, which limits the current treatment options available and reduces the survival rate. Therefore, RNAi-based therapy arises as a promising option to treat lung cancer. Read More

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http://dx.doi.org/10.1080/17425247.2018.1517744DOI Listing
October 2018
2 Reads

Dissolving microneedles for intradermal vaccination: manufacture, formulation, and stakeholder considerations.

Expert Opin Drug Deliv 2018 Nov 19;15(11):1039-1043. Epub 2018 Sep 19.

a School of Pharmacy, Medical Biology Centre , Queens University Belfast , Belfast , UK.

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http://dx.doi.org/10.1080/17425247.2018.1522301DOI Listing
November 2018

Optimization of siRNA delivery to target sites: issues and future directions.

Expert Opin Drug Deliv 2018 Nov 25;15(11):1053-1065. Epub 2018 Sep 25.

a Faculty of Pharmaceutical Sciences , Hokkaido University , Sapporo , Japan.

Introduction: The discovery of RNA interference (RNAi) earned the 2006 Nobel Prize in Physiology or Medicine for its biological significance and potential for developing novel therapeutics. The small interfering RNA (siRNA) is the most promising tool for translating RNAi to clinical use. Efforts are ongoing to improve siRNA delivery through developing novel biomaterials and delivery strategies. Read More

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https://www.tandfonline.com/doi/full/10.1080/17425247.2018.1
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http://dx.doi.org/10.1080/17425247.2018.1520836DOI Listing
November 2018
10 Reads

Design and in vitro release study of siRNA loaded Layer by Layer nanoparticles with sustained gene silencing effect.

Expert Opin Drug Deliv 2018 Oct 10;15(10):937-949. Epub 2018 Sep 10.

a School of Materials Science and Engineering , Nanyang Technological University , Singapore.

Objectives: Clinical translation of siRNA therapeutics has been severely limited due to the lack of stable and sustained siRNA delivery systems. Furthermore, when nanocarrier systems with siRNA are administered systemically to treat diseases, insufficient doses reach the target tissue. Here we report the successful development of a new nanocarrier system for the management of fibrosis. Read More

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https://www.tandfonline.com/doi/full/10.1080/17425247.2018.1
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http://dx.doi.org/10.1080/17425247.2018.1518426DOI Listing
October 2018
8 Reads

Overview of intranasally delivered peptides: key considerations for pharmaceutical development.

Expert Opin Drug Deliv 2018 Oct 19;15(10):991-1005. Epub 2018 Sep 19.

c Pharmaceutical Science , Biopharmaceutics and Specialty Dosage Form, Merck & Co., Inc ., Kenilworth , NJ , USA.

Introduction: Intranasal (IN) delivery for peptides provides unique advantages compared to other invasive systemic delivery routes. However, there still lacks a clear understanding on how to evaluate the potential of the peptides for nasal delivery and key considerations for the nasal formulation development. Areas covered: A retrospective analysis of intranasally delivered peptides was conducted. Read More

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http://dx.doi.org/10.1080/17425247.2018.1517742DOI Listing
October 2018
14 Reads

In situ gelling and mucoadhesive polymers: why do they need each other?

Expert Opin Drug Deliv 2018 Oct 7;15(10):1007-1019. Epub 2018 Sep 7.

a Department of Pharmaceutical Technology , Institute of Pharmacy, University of Innsbruck , Innsbruck , Austria.

Introduction: Mucosal drug delivery is an attractive route of administration, particularly in overcoming deficits of conventional dosage forms including high first-pass metabolism and poor bioavailability. Fast drainage from the target mucosa, however, represents a major limitation as it prevents sufficient drug absorption. In order to address these problems, mucoadhesive in situ gelling drug delivery systems have been investigated as they facilitate easy application in combination with a longer residence time at the administration site resulting in more desirable therapeutic effects. Read More

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http://dx.doi.org/10.1080/17425247.2018.1517741DOI Listing
October 2018
13 Reads

Rod-shaped mesoporous silica nanoparticles for nanomedicine: recent progress and perspectives.

Expert Opin Drug Deliv 2018 09 7;15(9):881-892. Epub 2018 Sep 7.

a School of Chemistry, Australian of NanoMedicine and ARC Centre of Excellence in Convergent Bio-Nano Science and Technology , University of New South Wales , Sydney , Australia.

Introduction: Interest in mesoporous silica nanoparticles for drug delivery has resulted in a good understanding of the impact of size and surface chemistry of these nanoparticles on their performance as drug carriers. Shape has emerged as an additional factor that can have a significant effect on delivery efficacy. Rod-shaped mesoporous silica nanoparticles show improvements in drug delivery relative to spherical mesoporous silica nanoparticles. Read More

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https://www.tandfonline.com/doi/full/10.1080/17425247.2018.1
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http://dx.doi.org/10.1080/17425247.2018.1517748DOI Listing
September 2018
17 Reads
4.840 Impact Factor

Use of in vitro performance models in the assessment of drug delivery across the human nail for nail disorders.

Expert Opin Drug Deliv 2018 Oct 7;15(10):983-989. Epub 2018 Sep 7.

a MedPharm Ltd , Guildford , UK.

Introduction: Onychomycosis is the most prevalent nail condition, affecting between 5% and 20% of the population in western countries. Oral therapies are not the treatment of choice due to poor patient compliance, high relapse rates, severe side effects, and contraindication. However, the difficultly in curing the condition using topical delivery is partly due to both the nail structure presenting a complex barrier and the lack of understanding of how best to achieve delivery of drug to the nail bed. Read More

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http://dx.doi.org/10.1080/17425247.2018.1518425DOI Listing
October 2018

Mitochondrial-targeted penetrating peptide delivery for cancer therapy.

Expert Opin Drug Deliv 2018 Oct 14;15(10):951-964. Epub 2018 Sep 14.

b Hubei Key Lab. of Tumor Microenvironment and Immunotherapy , China Three Gorges University , Yichang , China.

Introduction: Mitochondria are promising targeting organelles for anticancer strategies; however, mitochondria are difficult for antineoplastic drugs to recognize and bind. Mitochondria-penetrating peptides (MPPs) are unique tools to gain access to the cell interior and deliver a bioactive cargo into mitochondria. MPPs have combined or delivered a variety of antitumor cargoes and obviously inhibited the tumor growth in vivo and in vitro. Read More

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http://dx.doi.org/10.1080/17425247.2018.1517750DOI Listing
October 2018
3 Reads
4.840 Impact Factor

Advanced fabrication approaches to controlled delivery systems for epilepsy treatment.

Expert Opin Drug Deliv 2018 09 12;15(9):915-925. Epub 2018 Sep 12.

a ARC Centre of Excellence for Electromaterials Science, Intelligent Polymer Research Institute, AIIM Facility , University of Wollongong , Wollongong , Australia.

Introduction: Epilepsy is a chronic brain disease characterized by unprovoked seizures, which can have severe consequences including loss of awareness and death. Currently, 30% of epileptic patients do not receive adequate seizure alleviation from oral routes of medication. Over the last decade, local drug delivery to the focal area of the brain where the seizure originates has emerged as a potential alternative and may be achieved through the fabrication of drug-loaded polymeric implants for controlled on-site delivery. Read More

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https://www.tandfonline.com/doi/full/10.1080/17425247.2018.1
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http://dx.doi.org/10.1080/17425247.2018.1517745DOI Listing
September 2018
8 Reads

Clinical cosmeceutical repurposing of melatonin in androgenic alopecia using nanostructured lipid carriers prepared with antioxidant oils.

Expert Opin Drug Deliv 2018 Oct 10;15(10):927-935. Epub 2018 Sep 10.

a Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmaceutical Sciences and Pharmaceutical Industries , Future University in Egypt , Cairo , Egypt.

Background: The present work aims to formulate nanostructured lipid carriers (NLCs) exhibiting high skin deposition and high inherent antioxidant potential to repurpose the use of melatonin hormone and some antioxidant oils in the treatment of androgenic alopecia (AGA).

Research Design And Methods: NLCs were characterized for their size, charge, drug entrapment, anti-oxidant potential, physical stability, in vitro release, surface morphology, and ex-vivo skin deposition. Their merits were clinically tested on patients suffering from AGA by calculating the degree of improvement, conduction of hair pull test, histometric assessment, and dermoscopic evaluation. Read More

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https://www.tandfonline.com/doi/full/10.1080/17425247.2018.1
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http://dx.doi.org/10.1080/17425247.2018.1517740DOI Listing
October 2018
10 Reads

Clinical translation of immunoliposomes for cancer therapy: recent perspectives.

Expert Opin Drug Deliv 2018 09 12;15(9):893-903. Epub 2018 Sep 12.

a School of Life Sciences , Jilin University , Changchun , China.

Introduction: Liposomes have been extensively investigated as drug delivery vehicles. Immunoliposomes (ILs) are antibody-conjugated liposomes designed to selectively target antigen-expressing cells. ILs can be used to deliver drugs to tumor cells for improving efficacy and reducing toxicity. Read More

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http://dx.doi.org/10.1080/17425247.2018.1517747DOI Listing
September 2018
16 Reads

Delivery approaches for CRISPR/Cas9 therapeutics in vivo: advances and challenges.

Expert Opin Drug Deliv 2018 09 12;15(9):905-913. Epub 2018 Sep 12.

a Department of Chemistry , University of Massachusetts Amherst , Amherst , Massachusetts , USA.

Introduction: Therapeutic gene editing is becoming a viable biomedical tool with the emergence of the CRISPR/Cas9 system. CRISPR-based technologies have promise as a therapeutic platform for many human genetic diseases previously considered untreatable, providing a flexible approach to high-fidelity gene editing. For many diseases, such as sickle-cell disease and beta thalassemia, curative therapy may already be on the horizon, with CRISPR-based clinical trials slated for the next few years. Read More

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http://dx.doi.org/10.1080/17425247.2018.1517746DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295289PMC
September 2018
13 Reads