132,415 results match your criteria Expert Opinion on Drug Delivery[Journal]


National Institutes of Health Pathways to Prevention Workshop: Research Gaps for Long-Term Drug Therapies for Osteoporotic Fracture Prevention.

Ann Intern Med 2019 Apr 23. Epub 2019 Apr 23.

University of South Carolina, Arnold School of Public Health, Columbia, South Carolina (M.L.).

On 30 and 31 October 2018, the National Institutes of Health convened the Pathways to Prevention (P2P) Workshop: Appropriate Use of Drug Therapies for Osteoporotic Fracture Prevention to assess the available evidence on long-term (>3 years) use of drug therapies to prevent osteoporotic fractures and identify research gaps and needs for advancing the field. The workshop was cosponsored by the NIH Office of Disease Prevention (ODP), National Institute of Arthritis and Musculoskeletal and Skin Diseases, and National Institute on Aging. A multidisciplinary working group developed the agenda, and an Evidence-based Practice Center prepared an evidence report through a contract with the Agency for Healthcare Research and Quality to facilitate the discussion. Read More

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http://dx.doi.org/10.7326/M19-0961DOI Listing

Development and Pilot Testing of an Assessment Tool for Performance of Invasive Mediastinal Staging.

Ann Thorac Surg 2019 Apr 19. Epub 2019 Apr 19.

Thoracic Surgery, University of Alberta.

Background: To develop and evaluate a surgical trainee competency assessment instrument for invasive mediastinal staging, including cervical mediastinoscopy and endobronchial ultrasound (EBUS), a comprehensive instrument was developed utilizing expert review and simulated and clinical pilot-testing: Thoracic Competency Assessment Tool-Invasive Staging (TCAT-IS).

Methods: Validity and reliability evidence was collected and item analysis was performed. Initially, a 27-item instrument was developed, which underwent expert review with members of the Canadian Association of Thoracic Surgeons (n=86) in 2014-2015 (response rate 57%). Read More

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http://dx.doi.org/10.1016/j.athoracsur.2019.03.050DOI Listing

Artificial Neural Network Learns Clinical Assessment of Spasticity in Modified Ashworth Scale.

Arch Phys Med Rehabil 2019 Apr 19. Epub 2019 Apr 19.

Department of Mechanical Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Korea. Electronic address:

Objective: To propose an artificial intelligence (AI)-based decision-making rule in modified Ashworth scale (MAS) that draws maximum agreement from multiple human raters and to analyze how various biomechanical parameters affect scores in MAS.

Design: Prospective observational study SETTING: Two university hospitals PARTICIPANTS: Hemiplegic adults with elbow flexor spasticity due to acquired brain injury INTERVENTION: Not applicable MAIN OUTCOME MEASURES: 28 rehabilitation doctors and occupational therapists examined MAS of elbow flexors in 34 subjects with hemiplegia due to acquired brain injury while the MAS score and biomechanical data (i.e. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00039993193024
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http://dx.doi.org/10.1016/j.apmr.2019.03.016DOI Listing

Recent advances in gelatin-based therapeutics.

Expert Opin Biol Ther 2019 Apr 22. Epub 2019 Apr 22.

a NanoBioCel Group, Laboratory of Pharmaceutics, School of Pharmacy, University of the Basque Country UPV/EHU, Paseo de la Universidad 7 , Vitoria-Gasteiz 01006 , Spain .

Introduction: Biomaterials have provided a wide range of exciting opportunities in tissue engineering and regenerative medicine. Gelatin, a collagen-derived natural biopolymer, has been extensively used in regenerative medicine applications over the years, due to its cell-responsive properties and the capacity to deliver a wide range of biomolecules. Areas covered: The most relevant properties of gelatin as biomaterial are presented together with its main therapeutic applications. Read More

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http://dx.doi.org/10.1080/14712598.2019.1610383DOI Listing

An Evaluation of Mepolizumab for the Treatment of Severe Asthma.

Expert Opin Biol Ther 2019 Apr 22. Epub 2019 Apr 22.

c Department of Clinical and Experimental Medicine , University of Catania , Catania (CT) , Italy.

Introduction Asthma is considered one of the most common chronic conditions globally, characterized by variable airflow obstruction and symptoms. Severe asthma is diagnosed when asthma control requires high-intensity therapy or continues to remain uncontrolled despite treatment. Eosinophilic inflammation is known to be perpetuated by the activity of IL-5 in a proportion of severe asthma subjects, and targeting IL-5 may offer a therapeutic option. Read More

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https://www.tandfonline.com/doi/full/10.1080/14712598.2019.1
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http://dx.doi.org/10.1080/14712598.2019.1610382DOI Listing
April 2019
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Plant Proteome Databases and Bioinformatic Tools: An Expert Review and Comparative Insights.

OMICS 2019 Apr;23(4):190-206

1 Center for Systems Biology and Molecular Medicine, Yenepoya Research Centre, Yenepoya (Deemed to be University), Mangalore, India.

Historically, plant biology studies have lagged behind systems biology studies in animals and humans. However, there are signs of positive change as evidenced by the rise of big data in plant proteomics, and the availability of data science tools and next-generation sequencing technologies. Currently, the sequence information on nearly 300 plant species is available although they are curated to varying degrees of sophistication. Read More

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http://dx.doi.org/10.1089/omi.2019.0024DOI Listing

Eighteen Years of Holmium Laser Enucleation of the Prostate: A Single Center Experience.

J Urol 2019 Apr 22:101097JU0000000000000280. Epub 2019 Apr 22.

Department of Surgery, Division of Urology, McGill University Health Center , Montreal QC , Canada.

Purpose: To report our experience with long-term outcomes of the HoLEP procedure over a period of 18 years.

Materials And Methods: A review was performed of a prospectively collected database (March 1998 through June 2016) for patients undergoing HoLEP for symptomatic BPH performed or supervised by a single expert surgeon. Demographic and perioperative data were collected including the International Prostate Symptoms Score (IPSS), Quality of Life (QoL), peak flow rate (Qmax), post-void residual urine (PVR), and Prostate Specific Antigen (PSA). Read More

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http://dx.doi.org/10.1097/JU.0000000000000280DOI Listing
April 2019
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Development and Validation of a Canine Castration Model and Rubric.

J Vet Med Educ 2019 Apr 22:1-13. Epub 2019 Apr 22.

Veterinary educators use models to allow repetitive practice of surgical skills leading to clinical competence. Canine castration is a commonly performed procedure that is considered a Day One competency for a veterinarian. In this study, we sought to create and evaluate a canine pre-scrotal closed castration model and grading rubric using a validation framework of content evidence, internal structure evidence, and relationship with other variables. Read More

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http://dx.doi.org/10.3138/jvme.1117-158r1DOI Listing

Selection of adjuvants for vaccines targeting specific pathogens.

Expert Rev Vaccines 2019 Apr 22:1-17. Epub 2019 Apr 22.

a VIDO-InterVac , University of Saskatchewan , Saskatoon , Canada.

Introduction: Adjuvants form an integral component in most of the inactivated and subunit vaccine formulations. Careful and proper selection of adjuvants helps in promoting appropriate immune responses against target pathogens at both innate and adaptive levels such that protective immunity can be elicited. Areas covered: Herein, we describe the recent progress in our understanding of the mode of action of adjuvants that are licensed for use in human vaccines or in clinical or pre-clinical stages at both innate and adaptive levels. Read More

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http://dx.doi.org/10.1080/14760584.2019.1604231DOI Listing

Dataset for reporting of carcinoma of the urethra (in urethrectomy specimens): recommendations from the International Collaboration on Cancer Reporting (ICCR).

Histopathology 2019 Apr 22. Epub 2019 Apr 22.

Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, IUH Pathology Laboratory, Indianapolis, IN, USA.

Aims: The International Collaboration on Cancer Reporting (ICCR) is a not-for-profit organisation sponsored by the Royal Colleges of Pathologists of Australasia and the United Kingdom, the College of American Pathologists, the Canadian Association of Pathologists in association with the Canadian Partnership Against Cancer, the European Society of Pathology, the American Society of Clinical Pathology and the Faculty of Pathology, Royal College of Physicians of Ireland. Its goal is to produce standardized, internationally agreed upon, evidence-based datasets for cancer pathology reporting throughout the world.

Methods And Results: This paper describes the development of a cancer dataset by the multidisciplinary ICCR expert panel for the reporting of carcinoma of the urethra in urethrectomy specimens. Read More

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http://dx.doi.org/10.1111/his.13877DOI Listing

Smartphone Apps Targeting Alcohol and Illicit Substance Use: Systematic Search in in Commercial App Stores and Critical Content Analysis.

JMIR Mhealth Uhealth 2019 Apr 22;7(4):e11831. Epub 2019 Apr 22.

Department of Population Health, New York University School of Medicine, New York, NY, United States.

Background: Smartphone apps promise to enhance the reach of evidence-based interventions (cognitive behavior therapy, contingency management and therapeutic education system) for populations with substance use disorders, with minimal disruption to health systems. However, further studies are needed to systematically evaluate smartphone apps targeting alcohol and illicit substances.

Objective: The aim of this study was to evaluate the functionality, aesthetics, and quality of information of free or low-cost apps claiming to target alcohol, benzodiazepine, cocaine, crack/cocaine, crystal methamphetamine, and heroin use using the validated Mobile App Rating Scale (MARS) and critical content analysis. Read More

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http://dx.doi.org/10.2196/11831DOI Listing

Clinical pharmacokinetics and pharmacogenetics of tamoxifen and endoxifen.

Expert Rev Clin Pharmacol 2019 Apr 22. Epub 2019 Apr 22.

a Leiden Network for Personalised Therapeutics , Leiden University Medical Center , Leiden , The Netherlands.

Introduction: Tamoxifen dominates the anti-estrogenic therapy in the early and metastatic breast cancer setting. Tamoxifen has a complex metabolism, being mainly metabolized by CYP2D6 into its 30-100 times more potent metabolite, endoxifen. Recently, a phase I study in which endoxifen as an orally z-endoxifen hydrochloride, has been successfully evaluated. Read More

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http://dx.doi.org/10.1080/17512433.2019.1610390DOI Listing

Drug discovery strategies for acute radiation syndrome.

Expert Opin Drug Discov 2019 Apr 22:1-15. Epub 2019 Apr 22.

b Scientific Research Department , Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences , Bethesda , MD , USA.

Introduction: There are at the minimum two major, quite different approaches to advance drug discovery. The first being the target-based drug discovery (TBDD) approach that is commonly referred to as the molecular approach. The second approach is the phenotype-based drug discovery (PBDD), also known as physiology-based drug discovery or empirical approach. Read More

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http://dx.doi.org/10.1080/17460441.2019.1604674DOI Listing

Three-year outcome of everolimus-eluting bioresorbable vascular scaffold versus everolimus-eluting metallic stents: a comprehensive updated meta-analysis of randomized controlled trials.

Expert Rev Med Devices 2019 Apr 22. Epub 2019 Apr 22.

a Department of Cardiology , Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College 100037 Beijing China.

Objectives: To compare the efficacy of everolimus-eluting bioresorbable vascular scaffolds (EE-BRS) vs everolimus-eluting metallic stents (EES) for treatments of coronary artery diseases.

Methods: Searches were conducted in MEDLINE, EMBASE, EBSCO, Springer, Ovid, TCTMD, Cardiosource, Clinical Trial Results and the Cochrane Library with combined key words such as bioresorbable vascular scaffold, BVS, everolimus-eluting metallic stents, EES, coronary artery disease, CAD and randomized-Controlled Trials. Finally, 5,474 patients were enrolled for comparison of device-induced thrombosis, ischemia-driven target lesion revascularization (ID-TLR), device-oriented composite endpoints (DOCE), patient-oriented composite endpoints (POCE), and target vessel failure (TVF) between EE-BRS and EES treatments. Read More

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http://dx.doi.org/10.1080/17434440.2019.1610389DOI Listing

Fear of imminent death - use of evidence in forensic-psychiatric expertise.

Psychiatr Pol 2019 Feb 28;53(1):191-201. Epub 2019 Feb 28.

Instytut Psychologii, Wydział Filozofii Chrześcijańskiej, Uniwersytet Kardynała Stefana Wyszyńskiego w Warszawie.

In accordance with the Polish civil law, there are at least several ways to dispose of property in the event of death. One of them is a special form of oral testament. The main issue to be determined by the court is to either confirm or deny the existence of fear of imminent death of the testator at the time of bequest. Read More

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http://dx.doi.org/10.12740/PP/OnlineFirst/84797DOI Listing
February 2019

An Emergency Medicine Remediation Consult Service: Access to Expert Remediation Advice and Resources.

AEM Educ Train 2019 Apr 14;3(2):193-196. Epub 2019 Mar 14.

Department of Emergency Medicine Rutgers New Jersey Medical School Newark NJ.

Resident remediation is a complex and common issue in emergency medicine programs and requires a specific knowledge base. The Remediation Task Force (RTF) of the Council of Residency Directors in Emergency Medicine (CORD-EM) was created to identify remediation best practices and to develop tools for program directors. Initially housed on a Wiki page, and now located within the CORD-EM website, the RTF provides resources including accepted universal language for documentation and sample remediation plans. Read More

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http://dx.doi.org/10.1002/aet2.10330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457352PMC

Development and Empirical Testing of a Novel Team Leadership Assessment Measure: A Pilot Study Using Simulated and Live Patient Encounters.

AEM Educ Train 2019 Apr 19;3(2):163-171. Epub 2019 Feb 19.

Department of Emergency Medicine University of Washington School of Medicine Seattle WA.

Background: Team leadership is critical to health care resuscitation team performance. There has been increased focus on competency in team leadership behaviors; however, there is still variability in how team leadership is assessed within emergency medicine. The objective of this study was to develop and pilot a novel team leadership assessment measure for emergency medicine resuscitation teams. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/aet2.10321
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http://dx.doi.org/10.1002/aet2.10321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457354PMC
April 2019
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Next generation physiologically based kinetic (NG-PBK) models in support of regulatory decision making.

Comput Toxicol 2019 Feb;9:61-72

School of Engineering, University of Liverpool, Liverpool L69 3GH, UK.

The fields of toxicology and chemical risk assessment seek to reduce, and eventually replace, the use of animals for the prediction of toxicity in humans. In this context, physiologically based kinetic (PBK) modelling based on and kinetic data has the potential to a play significant role in reducing animal testing, by providing a methodology capable of incorporating human data to facilitate the development of to extrapolation of hazard information. In the present article, we discuss the challenges in: 1) applying PBK modelling to support regulatory decision making under the toxicology and risk-assessment paradigm shift towards animal replacement; 2) constructing PBK models without animal kinetic data, while relying solely on or methods for model parameterization; and 3) assessing the validity and credibility of PBK models built largely using non-animal data. Read More

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http://dx.doi.org/10.1016/j.comtox.2018.11.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472623PMC
February 2019

The effectiveness of narrative exposure therapy: a review, meta-analysis and meta-regression analysis.

Eur J Psychotraumatol 2019 25;10(1):1550344. Epub 2019 Mar 25.

Arq Psychotrauma Expert Group, Diemen, The Netherlands.

: Narrative exposure therapy (NET) is a short-term psychological treatment for post-traumatic stress disorder (PTSD) that has been investigated in various contexts among traumatized refugees and other trauma survivors. Sustained treatment results have been reported, but the methodological quality of the trials needs a more thorough examination. : To evaluate the effectiveness of NET for survivors of trauma, using a quality assessment, an updated meta-analysis, and a meta-regression analysis. Read More

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http://dx.doi.org/10.1080/20008198.2018.1550344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450467PMC

Determination of Visual Portfolio for Surgeons OverSeas Assessment of Surgical Needs Nigeria Study: Consensus Generation through an e-Delphi Process.

Niger J Surg 2019 Jan-Jun;25(1):30-35

Department of Surgery, College of Medicine, University of Lagos, Lagos, Nigeria.

Background: Surgery as a public health priority has received little attention until recently. There is a significant unmeasured and unmet burden of surgical illness in low- and middle-income countries (LMICs). Our aim was to generate a consensus among expert pediatric surgeons practicing in LMICs regarding the spectrum of pediatric surgical conditions that we should look out for in a community-based survey for Surgeons OverSeas Assessment of Surgical Needs Nigeria study. Read More

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http://dx.doi.org/10.4103/njs.NJS_30_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452749PMC

Expert Group Meeting on Aphasia: A Report.

Ann Indian Acad Neurol 2019 Apr-Jun;22(2):137-146

Aphasia Research Center, Maryland, USA.

A multidisciplinary team of experts took stock of the current state of affairs about many aspects of aphasia in India, including community burden, diagnostic assessment, therapy, rehabilitation, research, education, and advocacy. The broad spectrum of aphasiology was matched by the types of participants ranging from neurologists, speech-language pathologists, clinical psychologists, linguists, to experts in neuroimaging and computer sciences. Threadbare discussion in 16 sessions over 3 days leads to the identification of pressing problems and possible solutions. Read More

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http://dx.doi.org/10.4103/aian.AIAN_330_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472241PMC

How are clinician-educators evaluated for educational excellence? A survey of promotion and tenure committee members in the United States.

Med Teach 2019 Apr 21:1-7. Epub 2019 Apr 21.

d Department of Pediatrics , Renaissance School of Medicine at Stony Brook University , New York , NY , USA.

Background: In recent years, educational leaders have proposed domains of educational excellence and corresponding metrics to objectively measure contributions of clinician-educators for promotion and tenure (P&T). The purpose of this study was to explore whether P&T committees in United States (US) have incorporated these recommendations into practice.

Method: The authors conducted a survey of P&T leaders across institutions in US. Read More

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https://www.tandfonline.com/doi/full/10.1080/0142159X.2019.1
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http://dx.doi.org/10.1080/0142159X.2019.1596237DOI Listing
April 2019
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Selective drug deposition in lungs through pulmonary drug delivery system for effective management of drug-resistant TB.

Expert Opin Drug Deliv 2019 Apr 22. Epub 2019 Apr 22.

c Department of Chemistry & Biochemistry , Laurentian University , Sudbury , Canada.

Introduction: The emergence of multidrug resistant tuberculosis (MDR-TB) and extensively drug resistant tuberculosis (XDR-TB) is a major health issue and continues to be a global health concern. Despite significant advancements in treatment modalities, approximately 1.6 million deaths worldwide occur due to TB infection. Read More

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http://dx.doi.org/10.1080/17425247.2019.1609937DOI Listing

Total hip arthroplasty in the setting of tuberculosis infection of the hip: a systematic analysis of the current evidence.

Expert Rev Med Devices 2019 Apr 22:1-9. Epub 2019 Apr 22.

a Department of Orthopaedic Surgery , Cleveland Clinic , Cleveland , OH , USA.

Introduction: Total hip arthroplasty (THA) is a viable option to restore mobility and relieve pain in patients with severe post-tuberculous arthritis, but has been controversial due to concerns of disease reactivation. Over the past several decades, a number of authors have reported outcomes of THA for tuberculosis (TB) infections. However, there is marked heterogeneity in regard to disease activity, surgical approaches, and the use of chemoprophylaxis in these studies. Read More

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http://dx.doi.org/10.1080/17434440.2019.1606710DOI Listing

Detection and management of early stage inflammatory bowel disease: an update for clinicians.

Expert Rev Gastroenterol Hepatol 2019 Apr 22:1-9. Epub 2019 Apr 22.

a IBD Center, Department of Gastroenterology , Humanitas Research Hospital , Rozzano, Milan , Italy.

Introduction: Inflammatory bowel diseases, which include Crohn's disease and ulcerative colitis, are lifetime chronic and progressive disorders of poorly known etiology. Over the past few decades, new therapeutic approaches, including early and more aggressive intervention with immunomodulators and biological agents have offered the possibility of a favorable modification in the natural history of inflammatory bowel diseases. Area covered: Here, we review the literature about the effectiveness of early detection and intervention in adult inflammatory bowel diseases patients. Read More

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http://dx.doi.org/10.1080/17474124.2019.1605291DOI Listing

Emerging drugs for progressive supranuclear palsy.

Expert Opin Emerg Drugs 2019 Apr 21. Epub 2019 Apr 21.

a Parkinson's disease and Movement Disorders department , Hygeia Hospital , Athens , Greece.

Introduction: Progressive supranuclear palsy (PSP) is a common cause of atypical parkinsonism and a rapidly progressive disease that greatly burdens both patients and caregivers. Drugs with disease-modifying potential, targeting mechanisms implicated in the disease's pathogenesis are currently tested in Phase 1 and 2 trials. If proven efficacious, these compounds might provide substantial benefits not only to patients with PSP, but to patients with other tauopathies as well. Read More

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http://dx.doi.org/10.1080/14728214.2019.1609450DOI Listing

Recent advances in the development of polyethylenimine-based gene vectors for safe and efficient gene delivery.

Expert Opin Drug Deliv 2019 Apr 22:1-14. Epub 2019 Apr 22.

a Department of Pharmaceutics , China Pharmaceutical University , Nanjing , PR China.

Introduction: Despite the great therapeutic potential of gene therapy for treating critical diseases, the clinical application is limited by lack of safe and effective gene delivery vectors. Nonviral gene vectors have attracted tremendous attention due to the favorable loading capacity and facile manufacture. Among them, polyethylenimine-based gene vectors (PEIs) hold great promise for highly efficient gene delivery. Read More

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http://dx.doi.org/10.1080/17425247.2019.1604681DOI Listing

An update on contribution of hot-melt extrusion technology to novel drug delivery in the 21st century: part I.

Expert Opin Drug Deliv 2019 Apr 22. Epub 2019 Apr 22.

a Department of Pharmaceutics and Drug Delivery , The University of Mississippi, University , MS 38677.

Introduction: Currently, hot melt extrusion (HME) is a promising technology in the pharmaceutical industry, as evidenced by its application to manufacture various FDA-approved commercial products in the market. HME is extensively researched for enhancing the solubility and bioavailability of poorly water-soluble drugs, taste masking, and modifying release in drug delivery systems. Additionally, its other novel opportunities or pharmaceutical applications, and capability for continuous manufacturing are being investigated. Read More

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http://dx.doi.org/10.1080/17425247.2019.1609448DOI Listing

Clinico-pathologic and mammographic characteristics of inflammatory and non-inflammatory breast cancer at six centers in North Africa.

Breast Cancer Res Treat 2019 Apr 22. Epub 2019 Apr 22.

Medical School of the City University of New York, New York, NY, USA.

Purpose: We describe the clinico-pathologic and mammographic characteristics of inflammatory breast cancer (IBC) and non-IBC cases enrolled in a case-control study. Because IBC is a clinico-pathologic entity with rapid appearance of erythema and other signs, its diagnosis is based on clinical observation and thus, by necessity, subjective. Therefore, we evaluate our cases by photographic review by outside expert clinicians and by degree of adherence to the two most recent definitions of IBC: the international expert panel consensus statement and American Joint Committee on Cancer (AJCC) 8th edition (we used the slightly less restrictive 7th edition definition for our study). Read More

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http://dx.doi.org/10.1007/s10549-019-05237-5DOI Listing

Joint Indian Chest Society-National College of Chest Physicians (India) guidelines for spirometry.

Lung India 2019 Apr;36(Supplement):S1-S35

Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Although a simple and useful pulmonary function test, spirometry remains underutilized in India. The Indian Chest Society and National College of Chest Physicians (India) jointly supported an expert group to provide recommendations for spirometry in India. Based on a scientific grading of available published evidence, as well as other international recommendations, we propose a consensus statement for planning, performing and interpreting spirometry in a systematic manner across all levels of healthcare in India. Read More

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http://www.lungindia.com/text.asp?2019/36/7/1/256042
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http://dx.doi.org/10.4103/lungindia.lungindia_300_18DOI Listing

Prediction of long-term outcome after cognitive behavioral therapy for chronic fatigue syndrome.

J Psychosom Res 2019 Mar 19. Epub 2019 Mar 19.

Expert Center for Chronic Fatigue, Amsterdam University Medical Centers, Department of Medical Psychology, VU University, Amsterdam Public Health research institute, Amsterdam, The Netherlands; Amsterdam University Medical Centers, Department of Medical Psychology, University of Amsterdam, Amsterdam Public Health research institute, Amsterdam, The Netherlands. Electronic address:

Objective: To determine which variables predicted long-term outcome after cognitive behavioral therapy (CBT) for chronic fatigue syndrome (CFS).

Methods: A cohort of 511 CFS patients from four different CBT for CFS studies, i.e. Read More

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http://dx.doi.org/10.1016/j.jpsychores.2019.03.017DOI Listing

Consensus statements and expert guidance: interpret with care.

Authors:
Simon J Howell

Br J Anaesth 2019 Apr 19. Epub 2019 Apr 19.

Leeds Institute of Medical Research at St James's, University of Leeds, St James's University Hospital, Leeds, UK. Electronic address:

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http://dx.doi.org/10.1016/j.bja.2019.03.013DOI Listing

The fractal dimension of chromatin - a potential molecular marker for carcinogenesis, tumor progression and prognosis.

Expert Rev Mol Diagn 2019 Apr;19(4):299-312

b Department of Applied Mathematics , Institute of Mathematics, Statistics and Scientific Computing, State University of Campinas , Campinas , Brazil.

Introduction: Fractality is omnipresent in medicine and life sciences. In particular, the fractal principle is found simultaneously at different organization levels of the cell nucleus. The aim of this review is to show whether fractal characteristics of chromatin could be related to tumor pathology and pathophysiology. Read More

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http://dx.doi.org/10.1080/14737159.2019.1597707DOI Listing

Developments on antibiotics for multidrug resistant bacterial Gram-negative infections.

Expert Rev Anti Infect Ther 2019 Apr 20. Epub 2019 Apr 20.

a Alfa Institute of Biomedical Sciences , Athens , Greece.

Introduction: The constantly increasing spread of severe infections due to multi-drug resistant (MDR) Gram-negative bacteria (GNB) is a critical threat to the global medical community. After a long period of antibiotic pipeline pause, new antibiotic compounds are commercially available or are at late stages of clinical evaluation, promising to augment the therapeutic armamentarium of clinicians against deadly pathogens. Areas covered: This review summarizes available data regarding agents with potent activity against critical MDR Gram-negative pathogens, which urgently require new efficient antibiotics. Read More

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http://dx.doi.org/10.1080/14787210.2019.1610392DOI Listing

Hip Arthroscopy: Extra-articular Procedures.

Hip Int 2019 Apr 21:1120700019840729. Epub 2019 Apr 21.

2 American Hip Institute, Des Plaines, USA.

Hip preservation is one of the fastest growing fields in orthopaedics and indications of intra-articular procedures are well established. In the last decade, extra-articular procedures have gained momentum and arthroscopic solutions to peri-articular hip pathologies have been offered. It should be noted that many of these pathologies are well-treated conservatively and only those who fail conservative management should be treated operatively. Read More

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http://dx.doi.org/10.1177/1120700019840729DOI Listing

Novel Oral Lichen Planus Symptom Severity Measure for assessing patients' daily symptom experience.

Oral Dis 2019 Apr 21. Epub 2019 Apr 21.

AFYX Therapeutics, formerly known as Dermtreat, 2300, Copenhagen S, Denmark.

Objective: A novel Oral Lichen Planus Symptom Severity Measure was developed as a clinical outcome assessment of the daily symptom experience of patients with oral lichen planus.

Methods: A literature review and expert input were followed by open-ended concept elicitation interviews with 17 adults with oral lichen planus in the US and Ireland. Item content was generated and the interviews continued until input saturation was reached. Read More

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http://dx.doi.org/10.1111/odi.13109DOI Listing

Roche Troponin T hs-STAT meets all expert opinion analytical laboratory practice recommendations for the use of the differential diagnosis of acute coronary syndrome.

Clin Chem Lab Med 2019 Apr 22. Epub 2019 Apr 22.

Clinical Laboratory, Catharina Hospital, Eindhoven, The Netherlands.

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http://dx.doi.org/10.1515/cclm-2019-0267DOI Listing

Establishment of an international autoantibody reference standard for human anti-DFS70 antibodies: proof-of-concept study for a novel Megapool strategy by pooling individual specific sera.

Clin Chem Lab Med 2019 Apr 22. Epub 2019 Apr 22.

Rheumatology Division, Escola Paulista de Medicina, Universidade Federal de São Paulo, Rua Botucatu 740 3° andar, 04023-062 São Paulo, Brazil.

Background International autoantibody standards, traditionally based on material obtained from plasmapheresis of single subjects, represent individual immune response and may not comprehend the heterogeneity of the general population. The anti-DFS70 autoantibody yields a characteristic dense fine speckled (DFS) nuclear pattern on indirect immunofluorescence assay on HEp-2 cells (HEp-2 IFA) and speaks against autoimmunity. We propose a novel strategy for developing autoantibody reference standards, based on stepwise pooling of serum samples from hundreds of individuals with anti-DFS70 antibodies. Read More

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http://www.degruyter.com/view/j/cclm.ahead-of-print/cclm-201
Publisher Site
http://dx.doi.org/10.1515/cclm-2019-0087DOI Listing
April 2019
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Outcome of kidney transplantation from young pediatric donors (aged less than 6 years) to young size-matched recipients.

J Pediatr Urol 2019 Mar 28. Epub 2019 Mar 28.

Department of Pediatric Nephrology, University Hospital Vall d'Hebron, Hospital Vall d'Hebron, Passeig de la Vall d'Hebrón 119-129, 08035, Barcelona, Spain; School of Medicine, Universitat Autonoma de Barcelona, Hospital Vall d'Hebron, Passeig de la Vall d'Hebrón 119-129, 08035, Barcelona, Spain.

Introduction: Pediatric donation is underutilized because of presumed increased risk of vascular thrombosis (VT) and graft loss. Using young pediatric donors (YPDs) for young pediatric recipients (YPRs) is suggested to be even at greater risk and therefore precluded in many centers. The aim of this study was to analyze the outcome of kidney transplantation (KT) from YPD to age-matched YPR. Read More

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http://dx.doi.org/10.1016/j.jpurol.2019.03.015DOI Listing

French Society of ENT (SFORL) guidelines. Indications for cochlear implantation in adults.

Eur Ann Otorhinolaryngol Head Neck Dis 2019 Apr 17. Epub 2019 Apr 17.

Service ORL et chirurgie cervico-faciale, hôpital Edouard Herriot, HCL, 5, place d'Arsonval, 69003 Lyon, France.

The authors present the guidelines of the French Society of ENT and Head and Neck Surgery (SFORL) regarding indications for cochlear implantation in adults. After a literature review by a multidisciplinary workgroup, guidelines were drawn up based on retrieved articles and group-members' experience, then read over by an independent reading group to edit the final version. Guidelines were graded A, B, C or "expert opinion" according to decreasing level of evidence. Read More

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http://dx.doi.org/10.1016/j.anorl.2019.04.006DOI Listing

Invited review: Completeness of reporting of experiments: REFLECTing on a year of animal trials in the Journal of Dairy Science.

J Dairy Sci 2019 Apr 17. Epub 2019 Apr 17.

Department of Population Medicine, University of Guelph, 50 Stone Road East, Guelph, Ontario, N1G 2W1, Canada.

Reproducibility is an essential element of the scientific process, and it requires clear and complete reporting of study design, conduct, and analysis. In the human and animal health literature, incomplete reporting is associated with biased effect estimates. Moreover, incomplete reporting precludes knowledge synthesis and undervalues the resources allocated to the primary research. Read More

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http://dx.doi.org/10.3168/jds.2018-15797DOI Listing

ECG interpretation skill acquisition: A review of learning, teaching and assessment.

J Electrocardiol 2019 Apr 12. Epub 2019 Apr 12.

School of Nursing, Ulster University, Shore Road, Jordanstown Campus, BT37 0QB, United Kingdom of Great Britain and Northern Ireland; Institute of Nursing and Health Research, Ulster University, Shore Road, Jordanstown Campus, BT37 0QB, United Kingdom of Great Britain and Northern Ireland.

The recording of 12 lead electrocardiograms (ECG) is one of the most useful and commonly performed medical procedures. ECGs are used in diagnosis, risk-stratification management decision-making, and assessment in response to therapy. The correct interpretation of 12 lead ECG recordings is complex and clinically challenging with misinterpretation having the potential to result in poor outcomes or even patient fatality. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00220736183064
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http://dx.doi.org/10.1016/j.jelectrocard.2019.03.010DOI Listing
April 2019
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Qualitative versus quantitative lumbar spinal stenosis grading by machine learning supported texture analysis-Experience from the LSOS study cohort.

Eur J Radiol 2019 May 19;114:45-50. Epub 2019 Feb 19.

Institute of Diagnostic and Interventional Radiology, University Hospital Zurich, Zurich, Switzerland.

Purpose: To investigate and compare the reproducibility and accuracy of qualitative ratings and quantitative texture analysis (TA) in detection and grading of lumbar spinal stenosis (LSS) in magnetic resonance imaging (MR) scans of the lumbar spine.

Materials And Methods: From a nationwide multicenter and multidisciplinary lumbar stenosis outcome study (LSOS) register 82 patients, undergoing MR scans of the lumbar spine due to clinical indication of spinal claudication, with a single level central or lateral severe LSS were included. In total 343 transaxial T2-weighted images of the lumbar spine were included from one to five levels (L1 to S1) per patient. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0720048X193007
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http://dx.doi.org/10.1016/j.ejrad.2019.02.023DOI Listing
May 2019
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Neutrophil and Monocyte Counts in Heparin-Induced Thrombocytopenia.

Thromb Haemost 2019 Apr 20. Epub 2019 Apr 20.

Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.

Background:  Heparin-induced thrombocytopenia (HIT) antibodies activate platelets, monocytes and neutrophils. Despite these findings, it is unknown whether white blood cell (WBC) counts, including neutrophils and monocytes, are altered during HIT.

Materials And Methods:  We evaluated changes in total WBC counts (including WBC subsets), in 50 post-cardiac surgery patients with serologically confirmed HIT (30 patients with HIT-associated thrombosis). Read More

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http://dx.doi.org/10.1055/s-0039-1683913DOI Listing
April 2019
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Association between preoperative adenomyosis detection rate during pelvic ultrasonography and the specialty of the reading physician.

J Minim Invasive Gynecol 2019 Apr 17. Epub 2019 Apr 17.

Department of Obstetrics and Gynecology, University of South Florida, Morsani College of Medicine, Tampa, FL. Electronic address:

Study Objective: To compare the detection rate of adenomyosis when ultrasound is performed by a radiologist compared to a gynecologic expert sonologist.

Design: A retrospective, single center study.

Setting: University teaching hospital PATIENTS: All women above 18 years of age with a positive histopathology diagnosis of adenomyosis obtained in a hysterectomy specimen from October 1, 2011 - October 1, 2017 were screened for inclusion. Read More

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http://dx.doi.org/10.1016/j.jmig.2019.04.015DOI Listing

Systematic optimization of cationic surface engineered mucoadhesive vesicles employing Design of Experiment (DoE): A preclinical investigation.

Int J Biol Macromol 2019 Apr 17. Epub 2019 Apr 17.

Pharmaceutics Research Projects Laboratory, Department of Pharmaceutical Sciences, Dr Hari Singh Gour Central University, Sagar, M.P. 470 003, India. Electronic address:

Fungal keratitis (FK) is treated by topical natamycin (Nat) which is an effective antifungal agent. However, it has numerous therapeutic limitations i.e. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.04.118DOI Listing
April 2019
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The anatomic location of Barrett's esophagus recurrence after endoscopic eradication therapy: development of a simplified surveillance biopsy strategy.

Gastrointest Endosc 2019 Apr 17. Epub 2019 Apr 17.

University of California - Los Angeles, Los Angeles, California, USA. Electronic address:

Background And Aims: Surveillance endoscopy is recommended after endoscopic eradication therapy (EET) for Barrett's esophagus (BE) due to the risk recurrence. Currently recommended biopsy protocols are based on expert opinion and consist of sampling visible lesions followed by random 4-quadrant biopsies throughout the length of the original BE segment. Despite this protocol, some recurrences are not visibly identified. Read More

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http://dx.doi.org/10.1016/j.gie.2019.04.216DOI Listing

Data impress… but beliefs seduce.

Authors:
Michael Gitlin

Bipolar Disord 2019 Apr 20. Epub 2019 Apr 20.

Geffen School of Medicine at UCLA.

Aside from the quest/development of a reliable diagnostic system-e.g. the DSM and/or ICD- in which the meanings and definitions of words and diagnoses are consensually agreed upon, the most important development in modern clinical psychiatry has been the evolution of a data base of clinical studies, using research designs so that efficacy can be demonstrated by studies as opposed to being opined by one expert or another. Read More

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http://dx.doi.org/10.1111/bdi.12777DOI Listing

A Realistic Review of the Drug-Injury Relief System in Taiwan: Challenges, Lessons, and Achievements.

Clin Pharmacol Ther 2019 Apr 20. Epub 2019 Apr 20.

Taiwan Drug Relief Foundation, Taipei, Taiwan.

The drug injury relief system in Taiwan was implemented 20 years ago, with the goal of providing timely relief for drug injuries incurred by the proper use of legal drugs. This system utilizes a non-litigation expert review process to evaluate drug injury relief applications, and 2,732 applications have been reviewed from 1999 to 2016. Of these, 1,572 applications received relief payments, an approval rate of 58%. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/cpt.1474
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http://dx.doi.org/10.1002/cpt.1474DOI Listing
April 2019
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Scabies PCR with standardized dry swab sampling Easy tool for cluster diagnosis of human scabies.

Br J Dermatol 2019 Apr 20. Epub 2019 Apr 20.

Urgences pédiatriques, Centre Hospitalier Universitaire Hôpital pédiatrique Lenval, Nice, France.

Background: Expert visualization of Sarcoptes scabiei remains essential for diagnosing human scabies but access to experts can be difficult. PCR is a very specific tool for the detection and confirmation of Sarcoptes scabiei but this test has a poor sensitivity because of the requirement of previous expertise when collecting appropriate samples to gain a positive result.

Objective: Evaluate PCR as a diagnostic method for scabies using non expert-dependent standardized sampling. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/bjd.18017
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http://dx.doi.org/10.1111/bjd.18017DOI Listing
April 2019
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