13,262 results match your criteria Experimental neurology[Journal]


Mitoquinone attenuates blood-brain barrier disruption through Nrf2/PHB2/OPA1 pathway after subarachnoid hemorrhage in rats.

Exp Neurol 2019 Feb 16. Epub 2019 Feb 16.

Department of Physiology and Pharmacology, Loma Linda University, 11041 Campus St, Risley Hall, Room 219, Loma Linda, CA 92354, USA. Electronic address:

Background And Purpose: Mitochondrial dysfunction is involved in the mechanism of early brain injury (EBI) following subarachnoid hemorrhage (SAH). Blood-brain barrier disruption is a devastating outcome in the early stage of SAH. In this study, we aimed to investigate the role of a mitochondria-related drug Mitoquinone (MitoQ) in blood-brain barrier disruption after SAH in rats. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.expneurol.2019.02.009DOI Listing
February 2019

Self-propagating, non-synaptic epileptiform activity propagates by endogenous electric fields.

Exp Neurol 2019 Feb 15. Epub 2019 Feb 15.

Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA. Electronic address:

It is well documented that synapses play a significant role in the transmission of information between neurons. However, in the absence of synaptic transmission, neural activity has been observed to continue to propagate. Previous studies have shown that propagation of epileptiform activity takes place in the absence of synaptic transmission and gap junctions and is outside the range of ionic diffusion and axonal conduction. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.expneurol.2019.02.005DOI Listing
February 2019

Endogenous multidien rhythm of epilepsy in rats.

Exp Neurol 2019 Feb 15. Epub 2019 Feb 15.

Aix Marseille Univ, INSERM, INS, Inst Neurosci Syst, Marseille, France.

Recent trials of chronic EEG in humans showed that epilepsy is a cyclical disorder of the brain with rhythms at multiple time-scales: circadian, multi-day (multidien) or even seasonal. Here, we analyzed chronic EEG data (>30 days) in male epileptic rats and unraveled not only circadian but also, slower, multidien rhythms of interictal epileptiform activity with periodicity of about 2-3 and 5-7 days. Importantly, seizures were not uniformly distributed over time, but rather clustered at preferential phases of these underlying rhythms, delineating critical circadian times and multidien phase of heightened seizure risk. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.expneurol.2019.02.006DOI Listing
February 2019
1 Read

Parkinson's disease and pain: Modulation of nociceptive circuitry in a rat model of nigrostriatal lesion.

Exp Neurol 2019 Feb 14;315:72-81. Epub 2019 Feb 14.

Laboratory of Neuroscience, Hospital Sírio-Libanês, São Paulo, SP, Brazil. Electronic address:

Parkinson's disease (PD) is a neurodegenerative disorder that causes progressive dysfunction of dopaminergic and non-dopaminergic neurons, generating motor and nonmotor signs and symptoms. Pain is reported as the most bothersome nonmotor symptom in PD; however, pain remains overlooked and poorly understood. In this study, we evaluated the nociceptive behavior and the descending analgesia circuitry in a rat model of PD. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.expneurol.2019.02.007DOI Listing
February 2019

Methylphenidate administration reverts attentional inflexibility in adolescent rats submitted to a model of neonatal hypoxia-ischemia: Predictive validity for ADHD study.

Exp Neurol 2019 Feb 13. Epub 2019 Feb 13.

Programa de Pós-Graduação em Neurociências, Instituto de Ciências Básicas da Saúde (ICBS), Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil; Departamento de Ciências Morfológicas, ICBS, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.

Perinatal complications such as birth asphyxia were associated with a higher risk for Attention-Deficit/Hyperactivity Disorder (ADHD) in humans. Data from a rat model of neonatal hypoxia-ischemia (HI) have revealed inattention, impulsive behavior and dopamine (DA) disturbances in the prefrontal cortex (PFC), confirming the face validity and construct validity for ADHD study. However, the predictive validity (similar therapeutic efficacy of the pharmacological treatment available in the clinic) should be considered. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.expneurol.2019.02.004DOI Listing
February 2019
1 Read

Treatment of myotonia congenita with retigabine in mice.

Exp Neurol 2019 Feb 7;315:52-59. Epub 2019 Feb 7.

Department of Neuroscience, Cell Biology and Physiology, Wright State University, Dayton, OH 45435, United States. Electronic address:

Patients with myotonia congenita suffer from muscle stiffness caused by muscle hyperexcitability. Although loss-of-function mutations in the ClC-1 muscle chloride channel have been known for 25 years to cause myotonia congenita, this discovery has led to little progress on development of therapy. Currently, treatment is primarily focused on reducing hyperexcitability by blocking Na current. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.expneurol.2019.02.002DOI Listing
February 2019

Conditioning electrical stimulation promotes functional nerve regeneration.

Exp Neurol 2019 Feb 5;315:60-71. Epub 2019 Feb 5.

Department of Surgery, University of Alberta, Edmonton, AB T6G 2H7, Canada. Electronic address:

Peripheral nerve regeneration following injury is often incomplete, resulting in significant personal and socioeconomic costs. Although a conditioning crush lesion prior to surgical nerve transection and repair greatly promotes nerve regeneration and functional recovery, feasibility and ethical considerations have hindered its clinical applicability. In a recent proof of principle study, we demonstrated that conditioning electrical stimulation (CES) had effects on early nerve regeneration, similar to that seen in conditioning crush lesions (CCL). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.expneurol.2019.02.001DOI Listing
February 2019

Chronic treatment with galantamine rescues reversal learning in an attentional set-shifting test after experimental brain trauma.

Exp Neurol 2019 Jan 31;315:32-41. Epub 2019 Jan 31.

Physical Medicine & Rehabilitation, University of Pittsburgh, Pittsburgh, PA 15213, United States; Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, PA 15213, United States; Neurobiology, University of Pittsburgh, Pittsburgh, PA 15213, United States; Center for Neuroscience, University of Pittsburgh, Pittsburgh, PA 15213, United States. Electronic address:

Approximately 10 million new cases of traumatic brain injury (TBI) are reported each year worldwide with many of these injuries resulting in higher order cognitive impairments. Galantamine (GAL), an acetylcholine esterase inhibitor (AChEI) and positive allosteric modulator of nicotinic acetylcholine receptors (nAChRs), has been reported to ameliorate cognitive deficits after clinical TBI. Previously, we demonstrated that controlled cortical impact (CCI) injury to rats resulted in significant executive function impairments as measured by the attentional set-shifting test (AST), a complex cognitive task analogous to the Wisconsin Card Sorting Test (WCST). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.expneurol.2019.01.019DOI Listing
January 2019

Mild blast-related TBI in a mouse model alters amygdalar neurostructure and circuitry.

Exp Neurol 2019 Jan 31;315:9-14. Epub 2019 Jan 31.

Department of Anatomy and Anthropology, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv 69978, Israel; Dr. Miriam and Sheldon G. Adelson Chair, Center for the Biology of Addictive Diseases, Tel Aviv University, Tel Aviv 69978, Israel.

Traumatic brain injury (TBI) continues to be a signature injury of our modern conflicts. Due in part to increased use of improvised explosive devices (IEDs), we have seen blast trauma make up a significant portion of TBIs sustained by deployed troops and civilians. In addition to the physical injury, TBI is also a common comorbidity with post-traumatic stress disorder (PTSD). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.expneurol.2019.01.020DOI Listing
January 2019

Experimental traumatic brain injury results in estrous cycle disruption, neurobehavioral deficits, and impaired GSK3β/β-catenin signaling in female rats.

Exp Neurol 2019 Jan 31;315:42-51. Epub 2019 Jan 31.

NeuroBehavioral Research Laboratory, Department of Veterans Affairs, New Jersey Health Care System, East Orange, NJ, USA; Graduate School of Biomedical Sciences, Rutgers Biomedical and Health Sciences, 65 Bergen Street, Newark, NJ 07103, USA; Department of Pharmacology, Physiology and Neuroscience, New Jersey Medical School, Rutgers Biomedical and Health Science, Newark, NJ, USA. Electronic address:

An estimated 2.8 million traumatic brain injuries (TBI) occur within the United States each year. Approximately 40% of new TBI cases are female, however few studies have investigated the effects of TBI on female subjects. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.expneurol.2019.01.017DOI Listing
January 2019

GATA-4 regulates neuronal apoptosis after intracerebral hemorrhage via the NF-κB/Bax/Caspase-3 pathway both in vivo and in vitro.

Exp Neurol 2019 Jan 30;315:21-31. Epub 2019 Jan 30.

Department of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou 215006, Jiangsu Province, China.

GATA-binding protein 4 (GATA-4),a member of the GATA family of transcription factors, is expressed in the normal brain and participates in the neural inflammatory response and senescence. However, few studies have investigated whether GATA-4 is involved in the brain damage induced by intracerebral hemorrhage (ICH). The aim of this study was to investigate in vivo and in vitro the role of GATA-4 in ICH-induced secondary brain injury (SBI) and its potential underlying mechanisms. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.expneurol.2019.01.018DOI Listing
January 2019
1 Read

Long non-coding RNA AK038897 aggravates cerebral ischemia/reperfusion injury via acting as a ceRNA for miR-26a-5p to target DAPK1.

Exp Neurol 2019 Apr 29;314:100-110. Epub 2019 Jan 29.

Department of Emergency Medicine, The First Affiliated Hospital of Kunming Medical University, No. 295 Xichang Road, Wu Hua District, Kunming 650032, Yunnan Province, China. Electronic address:

Emerging evidence has suggested a significant role of long non-coding RNAs (lncRNAs) in ischemic stroke by acting as competing endogenous RNAs (ceRNAs) for microRNAs (miRNAs) to regulate certain RNA transcripts. AK038897 is an lncRNA that was reported to be upregulated in rat brains in response to transient focal ischemia. We aimed to investigate the possible regulatory role of AK038897 in ischemic stroke. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00144886183039
Publisher Site
http://dx.doi.org/10.1016/j.expneurol.2019.01.009DOI Listing
April 2019
3 Reads
4.696 Impact Factor

Retinoid x receptor modulation protects against ER stress response and rescues glaucoma phenotypes in adult mice.

Exp Neurol 2019 Apr 28;314:111-125. Epub 2019 Jan 28.

Faculty of Medicine and Health Sciences, Macquarie University, F10A, 2 Technology Place, North Ryde, NSW 2109, Australia. Electronic address:

Retinoid X receptors (RXRs) play an important role in transcription, are involved in numerous cellular networks from cell proliferation to lipid metabolism and are essential for normal eye development. RXRs form homo or heterodimers with other nuclear receptors, bind to DNA response elements and regulate several biological processes including neurogenesis. Mounting evidence suggests that RXR activation by selective RXR modulators (sRXRms) may be neuroprotective in the central nervous system. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.expneurol.2019.01.015DOI Listing

Brain insulin resistance: A treatment target for cognitive impairment and anhedonia in depression.

Exp Neurol 2019 Jan 26;315:1-8. Epub 2019 Jan 26.

Mood Disorders Psychopharmacology Unit (MDPU), Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada; Department of Pharmacology, University of Toronto, Toronto, Ontario, Canada; Brain and Cognition Discovery Foundation (BCDF), Toronto, Ontario, Canada. Electronic address:

Type 2 Diabetes Mellitus (T2DM) and Major Depressive Disorder (MDD) are leading causes of disability worldwide. Indeed, both are costly and burdensome diseases at both individual and socio-economic levels. Notably, there are similar pathophysiological elements, which might explain the overlap in phenotypic symptoms and the high rate of comorbidity. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00144886183063
Publisher Site
http://dx.doi.org/10.1016/j.expneurol.2019.01.016DOI Listing
January 2019
10 Reads

Characterization of leptomeningeal inflammation in rodent experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis.

Exp Neurol 2019 Apr 23;314:82-90. Epub 2019 Jan 23.

Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA; Center for Biomedical Imaging at Clinical Translational Science Institute, University at Buffalo, State University of New York, Buffalo, NY, USA. Electronic address:

Background: Leptomeningeal inflammation, as evidenced by leptomeningeal contrast enhancement (LMCE), is associated to cortical pathology in multiple sclerosis. The temporal pattern of LMCE in experimental autoimmune encephalomyelitis (EAE) myelin oligodendrocyte glycoprotein (MOG) is unknown.

Objective: To investigate LMCE using serial MRI in the EAE model of MS, and its association with clinical disease progression. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00144886193001
Publisher Site
http://dx.doi.org/10.1016/j.expneurol.2019.01.013DOI Listing
April 2019
3 Reads

Opioid receptors inhibit the spinal AMPA receptor Ca permeability that mediates latent pain sensitization.

Exp Neurol 2019 Apr 17;314:58-66. Epub 2019 Jan 17.

Department of Anesthesiology, Pittsburgh Center for Pain Research, University of Pittsburgh School of Medicine, 200 Lothrop St. Pittsburgh, PA 15213, USA; Department of Physiology, University of Kentucky School of Medicine, 800 Rose, St. Lexington, KY 40536-0298, USA. Electronic address:

Acute inflammation induces sensitization of nociceptive neurons and triggers the accumulation of calcium permeable (CP) α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs) in the dorsal horn of the spinal cord. This coincides with behavioral signs of acute inflammatory pain, but whether CP-AMPARs contribute to chronic pain remains unclear. To evaluate this question, we first constructed current-voltage (IV) curves of C-fiber stimulus-evoked, AMPAR-mediated EPSCs in lamina II to test for inward rectification, a key characteristic of CP-AMPARs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.expneurol.2019.01.003DOI Listing
April 2019
2 Reads

Aripiprazole and environmental enrichment independently improve functional outcome after cortical impact injury in adult male rats, but their combination does not yield additional benefits.

Exp Neurol 2019 Apr 17;314:67-73. Epub 2019 Jan 17.

Physical Medicine & Rehabilitation, University of Pittsburgh, Pittsburgh, PA 15213, United States; Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, PA 15213, United States; Center for Neuroscience, University of Pittsburgh, Pittsburgh, PA 15213, United States; Center for the Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, PA 15213, United States; Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15213, United States; Psychology, University of Pittsburgh, Pittsburgh, PA 15213, United States. Electronic address:

Typical antipsychotic drugs (APDs) with Dantagonistic properties impede functional outcome after experimental traumatic brain injury (TBI) and reduce the effectiveness of environmental enrichment (EE). Here we test the hypothesis that aripiprazole (ARIP), an atypical APD with partial Dand 5-HTreceptor agonist activities will improve recovery after TBI and when combined with EE will further enhance the benefits. Anesthetized adult male rats received either a controlled cortical impact of moderate severity or sham injury and then were randomly assigned to EE or standard (STD) housing and once daily intraperitoneal injections of ARIP (0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.expneurol.2019.01.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378113PMC
April 2019
1 Read

Determinants of social behavior deficits and recovery after pediatric traumatic brain injury.

Exp Neurol 2019 Apr 14;314:34-45. Epub 2019 Jan 14.

Department of Neuroscience, Monash University, Prahran, VIC, Australia; Department of Medicine (Royal Melbourne Hospital), The University of Melbourne, Parkville, VIC, Australia. Electronic address:

Traumatic brain injury (TBI) during early childhood is associated with a particularly high risk of developing social behavior impairments, including deficits in social cognition that manifest as reduced social interactions, with profound consequences for the individuals' quality of life. A number of pre-injury, post-injury, and injury-related factors have been identified or hypothesized to determine the extent of social behavior problems after childhood TBI. These include variables associated with the individual themselves (e. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.expneurol.2019.01.007DOI Listing
April 2019
1 Read

Bioenergetic dysfunction in a zebrafish model of acute hyperammonemic decompensation.

Exp Neurol 2019 Apr 14;314:91-99. Epub 2019 Jan 14.

Center for Child and Adolescent Medicine, Division for Pediatric Neurology and Metabolic Medicine, University Hospital Heidelberg, Heidelberg, Germany.

Acute hyperammonemic encephalopathy is a life-threatening manifestation of individuals with urea cycle disorders, which is associated with high mortality rates and severe neurological sequelae in survivors. Cerebral bioenergetic failure has been proposed as one of the key mechanisms underlying hyperammonemia-induced brain damage, but data supporting this hypothesis remain inconclusive and partially contradictory. Using a previously established zebrafish model of acute hyperammonemic decompensation, we unraveled that acute hyperammonemia leads to a transamination-dependent withdrawal of 2-oxoglutarate (alpha-ketoglutarate) from the tricarboxylic acid (TCA) cycle with consecutive TCA cycle dysfunction, ultimately causing impaired oxidative phosphorylation with ATP shortage, decreased ATP/ADP-ratio and elevated lactate concentrations. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.expneurol.2019.01.008DOI Listing
April 2019
7 Reads

Astrocytes migrate from human neural stem cell grafts and functionally integrate into the injured rat spinal cord.

Exp Neurol 2019 Apr 15;314:46-57. Epub 2019 Jan 15.

Department of Neurosciences, University of California - San Diego, La Jolla, CA, USA; VA San Diego Healthcare System, San Diego, CA, USA. Electronic address:

Neural stem cells (NSCs) can differentiate into both neurons and glia after transplantation into spinal cord injury (SCI) sites. The neuronal component of stem cell grafts has the potential to form functional synaptic relays across the lesion site. The glial component may reform a blood-spinal cord barrier, support neuronal function, and contribute to remyelination. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.expneurol.2019.01.006DOI Listing
April 2019
1 Read

EPPS treatment attenuates traumatic brain injury in mice by reducing Aβ burden and ameliorating neuronal autophagic flux.

Exp Neurol 2019 Apr 9;314:20-33. Epub 2019 Jan 9.

Department of Neurosurgery, Neuroscience Institute, Penn State Hershey Medical Center, Hershey 17033, USA. Electronic address:

Beta-amyloid (Aβ) burden and impaired neuronal autophagy contribute to secondary brain injury after traumatic brain injury (TBI). 4-(2-hydroxyethyl)-1-piperazinepropanesulphonic acid (EPPS) treatment has been reported to reduce Aβ aggregation and rescue behavioral deficits in Alzheimer's disease-like mice. Here, we investigated neuroprotective effects of EPPS in a mouse model of TBI. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.expneurol.2019.01.002DOI Listing
April 2019
3 Reads

Childhood trauma and insulin resistance in patients suffering from depressive disorders.

Exp Neurol 2019 Jan 11;315:15-20. Epub 2019 Jan 11.

Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, New York, USA; Center for Neuroscience in Women's Health, Stanford University, Palo Alto, CA 91304, USA. Electronic address:

Objective: Insulin resistance (IR) is a metabolic dysfunction often co-morbid with major depressive disorder (MDD). The paths to development of MDD remain largely unspecified, highlighting a need for identification of risk factors. Here, we tested whether specific subscales of childhood trauma as well as family history of type-2 diabetes (Fam-Hx-Dm2) are risk factors for development of metabolic dysfunction and severity of depressive symptoms. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.expneurol.2019.01.005DOI Listing
January 2019
1 Read

Eternal sunshine of the neuromodulated mind: Altering fear memories through neuromodulation.

Exp Neurol 2019 Apr 10;314:9-19. Epub 2019 Jan 10.

School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region. Electronic address:

Anxiety disorders pose one of the greatest threats to mental health. Modern treatment methods exist but are hindered by relapse, toxicity, and low efficacy. The use of neuromodulation to treat anxiety disorders has shown promising results, yet its underpinning mechanisms remain poorly understood. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.expneurol.2019.01.004DOI Listing
April 2019
3 Reads

Engineering approaches to enhance neural tissue regeneration.

Authors:

Exp Neurol 2019 Jan 4. Epub 2019 Jan 4.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.expneurol.2019.01.001DOI Listing
January 2019
2 Reads

Activation of the hypothalamic paraventricular nucleus by acute intermittent hypoxia: Implications for sympathetic long-term facilitation neuroplasticity.

Exp Neurol 2019 Apr 31;314:1-8. Epub 2018 Dec 31.

Department of Cellular and Integrative Physiology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA; Center for Biomedical Neuroscience, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA. Electronic address:

Exposure to acute intermittent hypoxia (AIH) induces a progressive increase of sympathetic nerve activity (SNA) that reflects a form of neuroplasticity known as sympathetic long-term facilitation (sLTF). Our recent findings indicate that activity of neurons in the hypothalamic paraventricular nucleus (PVN) contributes to AIH-induced sLTF, but neither the intra-PVN distribution nor the neurochemical identity of AIH responsive neurons has been determined. Here, awake rats were exposed to 10 cycles of AIH and c-Fos immunohistochemistry was performed to identify transcriptionally activated neurons in rostral, middle and caudal planes of the PVN. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.expneurol.2018.12.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378125PMC
April 2019
1 Read

Reproducibility - The key towards clinical implementation of spinal cord injury treatments?

Exp Neurol 2019 Mar 31;313:135-136. Epub 2018 Dec 31.

Axon Growth and Regeneration, German Center for Neurodegenerative Diseases, Bonn, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.expneurol.2018.12.010DOI Listing
March 2019
1 Read

Daily acute intermittent hypoxia induced dynamic changes in dendritic mitochondrial ultrastructure and cytochrome oxidase activity in the pre-Bötzinger complex of rats.

Exp Neurol 2019 Mar 23;313:124-134. Epub 2018 Dec 23.

Department of Neurobiology, The Fourth Military Medical University, Xi'an 710032, PR China. Electronic address:

Mitochondria, as primary energy generators and Ca biosensor, are dynamically coupled to neuronal activities, and thus play a role in neuroplasticity. Here we report that respiratory neuroplasticity induced by daily acute intermittent hypoxia (dAIH) evoked adaptive changes in the ultrastructure and postsynaptic distribution of mitochondria in the pre-Bötzinger complex (pre-BötC). The metabolic marker of neuronal activity, cytochrome c oxidase (CO), and dendritic mitochondria were examined in pre-BötC neurons of adult Sprague-Dawley rats preconditioned with dAIH, which is known to induce long-term facilitation (LTF) in respiratory neural activities. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.expneurol.2018.12.008DOI Listing
March 2019
1 Read

Chronic stress increases pain sensitivity via activation of the rACC-BLA pathway in rats.

Exp Neurol 2019 Mar 23;313:109-123. Epub 2018 Dec 23.

Department of Neurobiology, School of Basic Medical Sciences and Neuroscience Research Institute, Peking University, Beijing 100083, China; The Second Affiliated Hospital of Xinxiang Medical University, Henan, Xinxiang 453002, China; Key Laboratory for Neuroscience, Ministry of Education/National Health Commission, Beijing 100083, China. Electronic address:

Exposure to chronic stress can produce maladaptive neurobiological changes in pathways associated with pain processing, which may cause stress-induced hyperalgesia (SIH). However, the underlying mechanisms still remain largely unknown. In previous studies, we have reported that the amygdala is involved in chronic forced swim (FS) stress-induced depressive-like behaviors and the exacerbation of neuropathic pain in rats, of which, the basolateral amygdala (BLA) and the central nucleus of the amygdala (CeA) are shown to play important roles in the integration of affective and sensory information including nociception. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.expneurol.2018.12.009DOI Listing
March 2019
3 Reads

Broadening the definition of brain insulin resistance in aging and Alzheimer's disease.

Exp Neurol 2019 Mar 18;313:79-87. Epub 2018 Dec 18.

University of Kentucky, Department of Pharmacology and Nutritional Sciences, 800 Rose St., Lexington, KY 40536, United States. Electronic address:

It has been >20 years since studies first revealed that the brain is insulin sensitive, highlighted by the expression of insulin receptors in neurons and glia, the presence of circulating brain insulin, and even localized insulin production. Following these discoveries, evidence of decreased brain insulin receptor number and function was reported in both clinical samples and animal models of aging and Alzheimer's disease, setting the stage for the hypothesis that neuronal insulin resistance may underlie memory loss in these conditions. The development of therapeutic insulin delivery to the brain using intranasal insulin administration has been shown to improve aspects of memory or learning in both humans and animal models. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.expneurol.2018.12.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370304PMC
March 2019
1 Read

KU-596 decreases mitochondrial superoxide and improves bioenergetics following downregulation of manganese superoxide dismutase in diabetic sensory neurons.

Exp Neurol 2019 Mar 15;313:88-97. Epub 2018 Dec 15.

Department of Pharmacology and Toxicology, University of Kansas, 5064 Malott Hall, 1251 Wescoe Hall Dr., Lawrence, KS 66045, USA. Electronic address:

Neuronal mitochondrial dysfunction and oxidative stress are key pathophysiologic mechanisms of diabetic peripheral neuropathy (DPN). KU-596 is a small molecule modulator of heat shock protein 90 (Hsp90) that can reverse clinically relevant measures of DPN in diabetic animal models. Mechanistically, drug efficacy requires Hsp70 and correlates with improving mitochondrial maximal respiratory capacity (MRC) and decreasing oxidative stress in diabetic sensory neurons. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.expneurol.2018.12.006DOI Listing
March 2019
4 Reads

Treadmill exercise ameliorates focal cerebral ischemia/reperfusion-induced neurological deficit by promoting dendritic modification and synaptic plasticity via upregulating caveolin-1/VEGF signaling pathways.

Exp Neurol 2019 Mar 13;313:60-78. Epub 2018 Dec 13.

Physical Medicine and Rehabilitation Center, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, No. 109, Xueyuanxi Road, Wenzhou 325027, Zhejiang, China. Electronic address:

Dendritic and synaptic plasticity in the penumbra are important processes and are considered to be therapeutic targets of ischemic stroke. Treadmill exercise is known to be a beneficial treatment following stroke. However, its effects and potential mechanism in promoting dendritic and synaptic plasticity remain unknown. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.expneurol.2018.12.005DOI Listing
March 2019
2 Reads

Mechanisms of decreased cholinergic arousal in focal seizures: In vivo whole-cell recordings from the pedunculopontine tegmental nucleus.

Exp Neurol 2019 Apr 10;314:74-81. Epub 2018 Dec 10.

Department of Neurology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA; Department of Neuroscience, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA; Department of Neurosurgery, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA. Electronic address:

Focal limbic seizures often impair consciousness/awareness with major negative impact on quality of life. Recent work has shown that limbic seizures depress brainstem arousal systems, including reduced action potential firing in a key node: cholinergic neurons of the pedunculopontine tegmental nucleus (PPT). In vivo whole-cell recordings have not previously been achieved in PPT, but are used here with the goal of elucidating the mechanisms of reduced PPT cholinergic neuronal activity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.expneurol.2018.11.008DOI Listing
April 2019
1 Read

GCN2 reduces inflammation by p-eIF2α/ATF4 pathway after intracerebral hemorrhage in mice.

Exp Neurol 2019 Mar 6;313:16-25. Epub 2018 Dec 6.

Department of Physiology and Pharmacology, Loma Linda University, School of Medicine, Loma Linda, CA, USA. Electronic address:

Intracerebral hemorrhage (ICH) is a common and severe neurological disorder, which is associated with high rates of mortality and morbidity. This study aimed to evaluate whether general control non-derepressible-2 (GCN2) stimulation ameliorated neuroinflammation after ICH. Male CD-1 mice were subjected to experimental ICH by infusion of bacterial collagenase. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00144886183037
Publisher Site
http://dx.doi.org/10.1016/j.expneurol.2018.12.004DOI Listing
March 2019
7 Reads

Significant changes in circular RNA in the mouse cerebral cortex around an injury site after traumatic brain injury.

Exp Neurol 2019 Mar 5;313:37-48. Epub 2018 Dec 5.

Department of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China. Electronic address:

Background And Objective: Circular RNA (circRNA) is an important type of non-coding RNA that has not been widely researched in traumatic brain injury (TBI). The present study aimd to detect the altered circRNA expression around an injury site in the mouse cerebral cortex after TBI and explore its potential functions.

Method: C57BL/6 mice were used to construct a controlled cortical impact (CCI) model to simulate TBI. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.expneurol.2018.12.003DOI Listing
March 2019
2 Reads
4.696 Impact Factor

Repetitive transcranial magnetic stimulation promotes functional recovery and differentiation of human neural stem cells in rats after ischemic stroke.

Exp Neurol 2019 Mar 4;313:1-9. Epub 2018 Dec 4.

Department of Rehabilitation Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China. Electronic address:

Stem cells hold great promise as a regenerative therapy for ischemic stroke by improving functional outcomes in animal models. However, there are some limitations regarding the cell transplantation, including low rate of survival and differentiation. Repetitive transcranial magnetic stimulation (rTMS) has been widely used in clinical trials as post-stroke rehabilitation in ischemic stroke and has shown to alleviate functional deficits following stroke. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00144886183042
Publisher Site
http://dx.doi.org/10.1016/j.expneurol.2018.12.002DOI Listing
March 2019
7 Reads

CNB-001, a pleiotropic drug is efficacious in embolized agyrencephalic New Zealand white rabbits and ischemic gyrencephalic cynomolgus monkeys.

Exp Neurol 2019 Mar 4;313:98-108. Epub 2018 Dec 4.

Cellular Neurobiology Laboratories, The Salk Institute, La Jolla, CA, USA.

Ischemic stroke is an acute neurodegenerative disease that is extremely devastating to patients, their families and society. Stroke is inadequately treated even with endovascular procedures and reperfusion therapy. Using an extensive translational screening process, we have developed a pleiotropic cytoprotective agent with the potential to positively impact a large population of brain ischemia patients and revolutionize the process used for the development of new drugs to treat complex brain disorders. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00144886183055
Publisher Site
http://dx.doi.org/10.1016/j.expneurol.2018.11.010DOI Listing
March 2019
12 Reads
4.696 Impact Factor

Comparison of electroencephalogram (EEG) response to MDPV versus the hallucinogenic drugs MK-801 and ketamine in rats.

Exp Neurol 2019 Mar 3;313:26-36. Epub 2018 Dec 3.

Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL, USA. Electronic address:

Synthetic cathinones, often marketed as 'bath salts', have been reported to induce an excited delirium syndrome with characteristic symptoms such as paranoid, hallucination and even aggression. 3,4-Methylenedioxypyrovalerone (MDPV), a norepinephrine-dopamine reuptake inhibitor (NDRI), is one of the psychoactive ingredients in bath salts. The present study utilized cortical EEG and brain microdialysis in rats to compare the effects of MDPV (0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.expneurol.2018.12.001DOI Listing
March 2019
3 Reads

rhIGF-1 reduces the permeability of the blood-brain barrier following intracerebral hemorrhage in mice.

Exp Neurol 2019 Feb 30;312:72-81. Epub 2018 Nov 30.

Department of Physiology, Loma Linda University School of Medicine, Risley Hall, Room 223, Loma Linda, CA 92354, USA; Department of Neurosurgery, Loma Linda University School of Medicine, Loma Linda, CA, USA. Electronic address:

Disruption of the blood-brain barrier results in the formation of edema and contributes to the loss of neurological function following intracerebral hemorrhage (ICH). This study examined insulin-like growth factor-1 (IGF-1) as a treatment and its mechanism of action for protecting the blood-brain barrier after ICH in mice. 171 Male CD-1 mice were subjected to ICH via collagenase or autologous blood. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.expneurol.2018.11.009DOI Listing
February 2019
1 Read

Vitamin D deficiency increases blood-brain barrier dysfunction after ischemic stroke in male rats.

Exp Neurol 2019 Feb 28;312:63-71. Epub 2018 Nov 28.

Department of Emergency Medicine, Brain Research Laboratory, Emory University, Atlanta, GA 30322, USA. Electronic address:

Because vitamin D hormone deficiency (VDH) can worsen severity and outcome for ischemic stroke, we examined the role of VDH in maintaining blood-brain-barrier (BBB integrity) in a rat model of stroke. In most types of stroke, the BBB is markedly compromised, potentially leading to a cascade of injury processes and functional deficits, so we examined a number of biomarkers associated with BBB disruption to determine whether VDH deficiency would further compromise the BBB following a stroke. Male Wistar rats were randomly assigned to one of two diet cohorts, VDH-sufficient (VDH) and VDH. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00144886183027
Publisher Site
http://dx.doi.org/10.1016/j.expneurol.2018.11.005DOI Listing
February 2019
10 Reads

Routes for the delivery of insulin to the central nervous system: A comparative review.

Exp Neurol 2019 Mar 27;313:10-15. Epub 2018 Nov 27.

Geriatric Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA; Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Washington, Seattle, WA, USA. Electronic address:

Central nervous system (CNS) insulin resistance is a condition in which the cells within the CNS do not respond to insulin appropriately and is often linked to aberrant CNS insulin levels. CNS insulin is primarily derived from the periphery. Aberrant CNS insulin levels can arise due to various factors including i) decreased endogenous insulin transport into the brain, across the blood-brain barrier (BBB), ii) reduced CNS sequestration of insulin, and iii) increased CNS degradation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.expneurol.2018.11.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369701PMC
March 2019
7 Reads

Tacrolimus inhibits Th1 and Th17 responses in MuSK-antibody positive myasthenia gravis patients.

Exp Neurol 2019 Feb 22;312:43-50. Epub 2018 Nov 22.

Department of Surgery, Duke University Medical Center, Durham, NC, USA. Electronic address:

Muscle specific tyrosine kinase antibody positive myasthenia gravis (MuSK- MG) is characterized by autoantibodies against the MuSK protein of the neuromuscular junction resulting in weakness of bulbar and proximal muscles. We previously demonstrated that patients with MuSK-MG have increased pro-inflammatory Th1 and Th17 responses. Tacrolimus, an immunosuppressant used in AChR-MG and transplantation patients, inhibits T cell responses through interference with IL-2 transcription. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.expneurol.2018.11.006DOI Listing
February 2019
17 Reads

Validation study of neurotrophin-3-releasing chitosan facilitation of neural tissue generation in the severely injured adult rat spinal cord.

Exp Neurol 2019 Feb 22;312:51-62. Epub 2018 Nov 22.

The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, 1095 NW 14th Terrace, Miami, FL 33136-1060, United States; Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, FL 33136, United States.

It was previously reported that a tube holding chitosan carriers loaded with neurotrophin-3 (NT-3), after insertion into a 5 mm long transection gap in the adult rat spinal cord, triggered de novo neural tissue generation and functional recovery. Here, we report an effort to validate these findings using stringent blinding methodologies, which are crucial for robustness in reproducing biomedical studies. Radio frequency identification (RFID) chips were utilized to label rats that were randomly assigned into three experimental groups: transection with chitosan-NT-3 implant (C-NT3), transection only (T-controls), and laminectomy only (S-controls), blinding the experimenters to the treatments. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.expneurol.2018.11.003DOI Listing
February 2019
4 Reads
4.696 Impact Factor

Genetic ablation of Gpr37l1 delays tumor occurrence in Ptch1 mouse models of medulloblastoma.

Exp Neurol 2019 Feb 16;312:33-42. Epub 2018 Nov 16.

Institute of Cell Biology and Neurobiology, Italian National Research Council (CNR), I-00015, Monterotondo Scalo, Rome, Italy.

The G-protein coupled receptor 37-like 1 (Gpr37l1) is specifically expressed in most astrocytic glial cells, including cerebellar Bergmann astrocytes and interacts with patched 1 (Ptch1), a co-receptor of the sonic hedgehog (Shh)-smoothened (Smo) signaling complex. Gpr37l1 null mutant mice exhibit precocious post-natal cerebellar development, with altered Shh-Smo mitogenic cascade and premature down-regulation of granule cell precursor (GCP) proliferation. Gpr37l1 expression is downregulated in medulloblastoma (MB) and upregulated in glioma and glioblastoma tumors. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.expneurol.2018.11.004DOI Listing
February 2019
12 Reads

Vitronectin from brain pericytes promotes adult forebrain neurogenesis by stimulating CNTF.

Exp Neurol 2019 Feb 6;312:20-32. Epub 2018 Nov 6.

Department of Biomedical Sciences, Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA. Electronic address:

Vitronectin (VTN) is a glycoprotein in the blood and affects hemostasis. VTN is also present in the extracellular matrix of various organs but little is known about its function in healthy adult tissues. We show, in adult mice, that VTN is uniquely expressed by approximately half of the pericytes of subventricular zone (SVZ) where neurogenesis continues throughout life. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.expneurol.2018.11.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326873PMC
February 2019
1 Read

Denervated mouse dentate granule cells adjust their excitatory but not inhibitory synapses following in vitro entorhinal cortex lesion.

Exp Neurol 2019 Feb 25;312:1-9. Epub 2018 Oct 25.

Department of Neuroanatomy, Institute of Anatomy and Cell Biology, Faculty of Medicine, University of Freiburg, Freiburg 79104, Germany. Electronic address:

Neurons adjust their synaptic strength in a homeostatic manner following changes in network activity and connectivity. While this form of plasticity has been studied in detail for excitatory synapses, homeostatic plasticity of inhibitory synapses remains not well-understood. In the present study, we employed entorhinal cortex lesion (ECL) of organotypic entorhino-hippocampal tissue cultures to test for homeostatic changes in GABAergic neurotransmission onto partially denervated dentate granule cells. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00144886183026
Publisher Site
http://dx.doi.org/10.1016/j.expneurol.2018.10.013DOI Listing
February 2019
2 Reads

Parkinsonian GM2 synthase knockout mice lacking mature gangliosides develop urinary dysfunction and neurogenic bladder.

Exp Neurol 2019 Jan 25;311:265-273. Epub 2018 Oct 25.

Department of Biomedical Sciences, Center of Emphasis in Neurosciences, Graduate School of Biomedical Sciences, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, TX 79905, USA.. Electronic address:

Parkinson's disease is a neurodegenerative disorder that reduces a patients' quality of life by the relentless progression of motor and non-motor symptoms. Among the non-motor symptoms is a condition called neurogenic bladder that is associated with detrusor muscle underactivity or overactivity occurring from neurologic damage. In Parkinson's disease, Lewy-body-like protein aggregation inside neurons typically contributes to pathology. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00144886183061
Publisher Site
http://dx.doi.org/10.1016/j.expneurol.2018.10.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319267PMC
January 2019
13 Reads

Sonic hedgehog regulation of cavernous nerve regeneration and neurite formation in aged pelvic plexus.

Exp Neurol 2019 Feb 2;312:10-19. Epub 2018 Nov 2.

Departments of Urology, Physiology and Bioengineering, University of Illinois at Chicago, Chicago, IL 60612, United States. Electronic address:

Introduction: Erectile dysfunction (ED) is a significant health concern that greatly impacts quality of life, and is common in men as they age, impacting 52% of men between the ages of 40 and 70. A significant underlying cause of ED development is injury to the cavernous nerve (CN), a peripheral nerve that innervates the penis. CN injury also occurs in up to 82% of prostatectomy patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.expneurol.2018.11.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342483PMC
February 2019
3 Reads

Impaired chemoreflex correlates with decreased c-Fos in respiratory brainstem centers of the streptozotocin-induced Alzheimer's disease rat model.

Exp Neurol 2019 Jan 23;311:285-292. Epub 2018 Oct 23.

Department of Physiology, Kirksville College of Osteopathic Medicine, A.T. Still University of Health Sciences, Kirksville, MO, USA. Electronic address:

Besides impairment in cognition and memory, patients with Alzheimer's disease (AD) often exhibit marked dysfunction in respiratory control. Sleep-disordered breathing (SDB) is commonly found in cases of AD, resulting in periods of hypoxia during sleep. Early structural changes in brainstem areas controlling respiratory function may account for SDB in the course of AD. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.expneurol.2018.10.012DOI Listing
January 2019
10 Reads

Neurogenesis changes and the fate of progenitor cells after subarachnoid hemorrhage in rats.

Exp Neurol 2019 Jan 23;311:274-284. Epub 2018 Oct 23.

Department of Neurosurgery, The third XiangYa Hospital, Central South University, Changsha 410013, China. Electronic address:

Background: Subarachnoid hemorrhage (SAH) is a devastating cerebrovascular disease that leads to poor outcomes. Neurogenesis, an essential recovery mechanism after brain injury, has not been fully elucidated after SAH.

Methods: A total of 122 SD rats were used in this study. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00144886183060
Publisher Site
http://dx.doi.org/10.1016/j.expneurol.2018.10.011DOI Listing
January 2019
5 Reads

Gene expression profiling in a mouse model of Dravet syndrome.

Exp Neurol 2019 Jan 19;311:247-256. Epub 2018 Oct 19.

Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. Electronic address:

Dravet syndrome is a severe, early-onset epileptic encephalopathy frequently resulting from de novo mutations of SCN1A. Mice with heterozygous deletion of Scn1a (Scn1a) model many features of Dravet syndrome, including spontaneous seizures and premature lethality. Scn1a mice exhibit variable phenotype penetrance and expressivity dependent upon the strain background. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00144886183059
Publisher Site
http://dx.doi.org/10.1016/j.expneurol.2018.10.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287761PMC
January 2019
9 Reads