1,427,858 results match your criteria Experimental biology and medicine Maywood N.J.[Journal]


Rear Admiral (Astronaut) Alan Shepard: Ménière's disease and the race to the moon.

J Neurosurg 2019 Feb 15:1-7. Epub 2019 Feb 15.

6Department of Neurosurgery, University of South Alabama, Mobile, Alabama.

On May 5, 1961, Alan B. Shepard Jr. piloted the Freedom 7 craft into a suborbital flight to become the first American man in space. Read More

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http://dx.doi.org/10.3171/2018.9.JNS182522DOI Listing
February 2019

Leptomeningeal dissemination: a sinister pattern of medulloblastoma growth.

J Neurosurg Pediatr 2019 Feb 15:1-9. Epub 2019 Feb 15.

3Cancer Research Program, Research Institute of the McGill University Health Center and Department of Surgery, McGill University, Montreal, Quebec, Canada.

Leptomeningeal dissemination (LMD) is the defining pattern of metastasis for medulloblastoma. Although LMD is responsible for virtually 100% of medulloblastoma deaths, it remains the least well-understood part of medulloblastoma pathogenesis. The fact that medulloblastomas rarely metastasize outside the CNS but rather spread almost exclusively to the spinal and intracranial leptomeninges has fostered the long-held belief that medulloblastoma cells spread directly through the CSF, not the bloodstream. Read More

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http://dx.doi.org/10.3171/2018.11.PEDS18506DOI Listing
February 2019

Validation of a methodology for neuro-urological and lumbosacral stimulation studies in domestic pigs: a humanlike animal model.

J Neurosurg Spine 2019 Feb 15:1-11. Epub 2019 Feb 15.

7Neurosurgery, Pellegrin Hospital, Bordeaux, Nouvelle Aquitaine; and.

OBJECTIVESpinal cord injuries (SCIs) result in loss of movement and sensory feedback, but also organ dysfunction. Nearly all patients with complete SCI lose bladder control and are prone to kidney failure if intermittent catheterization is not performed. Electrical stimulation of sacral spinal roots was initially considered to be a promising approach for restoring continence and micturition control, but many patients are discouraged by the need for surgical deafferentation as it could lead to a loss of sensory functions and reflexes. Read More

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http://dx.doi.org/10.3171/2018.11.SPINE18676DOI Listing
February 2019

Associations of blood levels of trace elements and heavy metals with metabolic syndrome in Chinese male adults with microRNA as mediators involved.

Environ Pollut 2019 Feb 6;248:66-73. Epub 2019 Feb 6.

Department of Occupational Health and Environmental Health, School of Public Health, Capital Medical University, Beijing, 100069, PR China; Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, 100069, PR China. Electronic address:

Metabolic syndrome (MetS) is a global health problem with an increasing prevalence. However, effects of trace elements and heavy metals on MetS and the mechanism underlying this effect are poorly understood. A preliminary cross-sectional study was conducted in 2015. Read More

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http://dx.doi.org/10.1016/j.envpol.2019.02.015DOI Listing
February 2019

MnO nanosheets as the biomimetic oxidase for rapid and sensitive oxalate detection combining with bionic E-eye.

Biosens Bioelectron 2019 Jan 21;130:254-261. Epub 2019 Jan 21.

Biosensor National Special Laboratory, Key Laboratory of Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, China; State Key Laboratory of Transducer Technology, Chinese Academy of Sciences, Shanghai 200050, China. Electronic address:

Urolithiasis commonly occurs in kidney and ureteral, and may cause local organ/tissue damage, even kidney failure. The incidence of this disease is increasing worldwide, in which calcium oxalate is the major composition forming the urinary calculus. Therefore, to monitor this disease for the prevention and treatment, measuring the oxalate in the urine is of great significance. Read More

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http://dx.doi.org/10.1016/j.bios.2019.01.026DOI Listing
January 2019

Direct and indirect effects of perception on generalization gradients.

Behav Res Ther 2019 Jan 18;114:44-50. Epub 2019 Jan 18.

Center for the Psychology of Learning and Experimental Psychopathology, Faculty of Psychology and Educational Sciences, KU Leuven, Tiensestraat 102, Box 3712, 3000, Leuven, Belgium.

For more than a century, researchers have attempted to understand why organisms behave similarly across situations. Despite the robust character of generalization, considerable variation in conditioned responding both between and within humans remains a challenge for contemporary generalization models. The current study aims to investigate the extent to which variation in behavior in a context of generalization can be attributed to differences in perception. Read More

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http://dx.doi.org/10.1016/j.brat.2019.01.006DOI Listing
January 2019

Fish Oil Increases Specialized Pro-resolving Lipid Mediators in PAD (The OMEGA-PAD II Trial).

J Surg Res 2019 Feb 13;238:164-174. Epub 2019 Feb 13.

Division of Vascular and Endovascular Surgery, Department of Surgery, University of California, San Francisco, California. Electronic address:

Background: N-3 polyunsaturated fatty acid (PUFA) supplementation has been associated with reduced mortality and inflammation in patients with cardiovascular disease. There are limited data on the effects of n-3 PUFA supplementation in patients with peripheral artery disease (PAD).

Materials And Methods: The OMEGA-PAD II trial was a double-blinded, randomized, placebo-controlled trial to assess the effect of 3 mo of high-dose oral n-3 PUFA supplementation on inflammation, endothelial function, and walking ability in patients with PAD. Read More

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http://dx.doi.org/10.1016/j.jss.2019.01.038DOI Listing
February 2019

Photocatalytic degradation of local dyeing wastewater by iodine-phosphorus co-doped tungsten trioxide nanocomposites under natural sunlight irradiation.

J Environ Manage 2019 Feb 13;236:519-533. Epub 2019 Feb 13.

Department of Physics, University of the Free State, P.O. Box 339, ZA-9300 Bloemfontein, South Africa.

In the present work, one-step green synthesis of WO based on the interaction of ammonium paratungstate and Spondias mombin leaves extract is reported. Different concentrations of iodine and phosphorus in the range of (2%, 5% and 10%) were firstly incorporated into the prepared WO nanoparticles to obtain Iodine doped and Phosphorus doped WO nanoparticles respectively. Subsequently, iodine and phosphorus co-doped WO nanocomposites was prepared using a wet impregnation method followed by calcination at high temperature. Read More

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http://dx.doi.org/10.1016/j.jenvman.2019.02.027DOI Listing
February 2019

Migration regularity of six preservatives from wooden children's products to saliva and sweat based on microstructure-related migration models.

Ecotoxicol Environ Saf 2019 Feb 13;173:149-155. Epub 2019 Feb 13.

Institute of Industrial and Consumer Product Safety, Chinese Academy of Inspection and Quarantine, Beijing 100176, China.

Wood preservatives in wooden children's products (WCPs) may migrate into children's body through oral and dermal exposure, resulting in a potential health risk. In this paper, a systematic investigation on the migration regularity of lindane and five chlorophenols preservatives from WCPs to saliva and sweat was introduced. Migration models were established based on the abundant migration data among different time periods (2 min-96 h). Read More

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http://dx.doi.org/10.1016/j.ecoenv.2019.01.108DOI Listing
February 2019

Concentrations of brominated and phosphorous flame retardants in Finnish house dust and insights into children's exposure.

Chemosphere 2019 Feb 8;223:99-107. Epub 2019 Feb 8.

Norwegian Institute of Public Health, Department of Environmental Exposure and Epidemiology, P.O. Box 4404, Nydalen, 0403, Oslo, Norway.

Brominated and phosphorous flame retardants (BFRs, PFRs) are added to household and consumer products to reduce their flammability. Some FRs are persistent in the environment and may have adverse health effects. As exposure indoors contributes significantly to total exposure, we wanted to estimate the exposure of children (3 years of age) through dust ingestion, inhalation, and dermal absorption. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2019.02.027DOI Listing
February 2019

Comparison of TSNAs concentration in saliva according to type of tobacco smoked.

Environ Res 2018 Dec 6;172:73-80. Epub 2018 Dec 6.

Group of Evaluation of Health Determinants and Health Policies, Department of Basic Sciences, Universitat Internacional de Catalunya, Carrer de Josep Trueta s/n, 08195 Sant Cugat del Vallès, Barcelona, Spain; Tobacco Control Unit, Cancer Prevention and Control Program, Institut Català d'Oncologia, L'Hospitalet de Llobregat, Barcelona, Spain; Cancer Prevention and Control Group, Institut d'Investigació Biomèdica de Bellvitge - IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain. Electronic address:

Objective: To compare tobacco-specific nitrosamines (TSNAs) measured in saliva according to different types of tobacco smoked in a sample of smokers of the city of Barcelona (Spain).

Methods: We used data from a cross-sectional study of a sample of the adult smoking population of Barcelona, Spain in 2013-2014 (n = 165). We classified smokers in five groups according to the type of tobacco smoked: a) manufactured cigarettes only, b) roll-your-own (RYO) cigarettes only, c) dual smokers (both manufactured and RYO cigarettes), d) manufactured plus other types of tobacco products different from RYO and e) other types of tobacco products different from manufactured and RYO cigarettes. Read More

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http://dx.doi.org/10.1016/j.envres.2018.12.006DOI Listing
December 2018

Movie violence acutely affects food choices in young adults.

Eat Behav 2019 Feb 10;33:7-12. Epub 2019 Feb 10.

Nutrition Division, Department of Natural Sciences, School of Arts and Sciences, Lebanese American University, Lebanon.

Background: Extensive research has been conducted to investigate the effects of media violence on attitudes, behaviors, and cardiovascular health; however, only few studies have examined its effect on appetite, eating behavior and food preferences. Little attention has been given to understand how movie genre manipulates the physiology and the eating behavior of individuals. The present study aimed at investigating the acute effect of violence content in movies on appetite perception, heart rate and blood pressure, along with food preferences and intake in young individuals. Read More

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http://dx.doi.org/10.1016/j.eatbeh.2019.02.002DOI Listing
February 2019

Cellulose nanocrystals/fluorinated polyacrylate soap-free emulsion prepared via RAFT-assisted Pickering emulsion polymerization.

Colloids Surf B Biointerfaces 2019 Feb 10;177:321-328. Epub 2019 Feb 10.

College of Bioresources Chemical and Materials Engineering, Shaanxi University of Science and Technology, Xi'an, 710021, China; National Demonstration Center for Experimental Light Chemistry Engineering Education (Shaanxi University of Science and Technology), China.

Cellulose nanocrystals/fluorinated polyacrylate soap-free emulsion was successfully synthesized via RAFT-assisted Pickering emulsion process using modified cellulose nanocrystals as particle stabilizers. The cellulose nanocrystals were organically modified by linear triblock copolymer poly(2-(dimethylamino) ethyl methacrylate)-b-poly(glycidyl methacrylate)-b-poly(2,2,3,4,4,4-Hexafluorobutyl acrylate) (PDMAEMA-b-PGMA-b-PHFBA) with reactive trithiocarbonate group. Transmission electron microscopy (TEM) and scanning electron microscopy (SEM) analyses showed that modified cellulose nanocrystals were armored on the surface of spherical particles. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2019.02.005DOI Listing
February 2019

Syngas production from biomass using Fe-based oxygen carrier: Optimization.

Bioresour Technol 2019 Feb 2;280:183-187. Epub 2019 Feb 2.

Collaborative Innovation Center of Biomass Energy, Henan Agricultural University, Henan Province, Zhengzhou 450002, China.

Chemical looping gasification is a promising technology to convert biomass into syngas with low adverse effects by heat loss and production dilution. This study utilized 60% loading FeO/AlO oxygen carrier (OC) for gasification tests on four biomass samples: rice straw, corn stalk, peanut shell and wheat straw under OC/biomass (OC/B) ratio of 1.0, steam/biomass (S/B) ratio of 2. Read More

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http://dx.doi.org/10.1016/j.biortech.2019.02.012DOI Listing
February 2019

Competitive dynamics of anaerobes during long-term biological sulfate reduction process in a UASB reactor.

Bioresour Technol 2019 Feb 5;280:173-182. Epub 2019 Feb 5.

Faculty of Environmental Engineering, The University of Kitakyushu, 1-1 Hibikino, Wakamatsu, Kitakyushu, Fukuoka 808-0135, Japan.

To reveal the long-term competitive dynamics of anaerobes in anaerobic bioreactors with sulfate reduction, a comprehensive structured mathematical model was designed for an extension of the Anaerobic Digestion Model No. 1 (ADM1). Sulfate reduction bacteria (SRB) were categorized into acetogenic-likewise SRB (ASRB) and methanogenic-likewise SRB (MSRB). Read More

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http://dx.doi.org/10.1016/j.biortech.2019.02.023DOI Listing
February 2019
4.494 Impact Factor

The Combination of MEK inhibitor with Immunomodulatory Antibodies Targeting PD-1 and PD-L1 Results in Prolonged Survival in Kras/p53-Driven Lung Cancer.

J Thorac Oncol 2019 Feb 13. Epub 2019 Feb 13.

Section of Medical Oncology, Department of Internal Medicine; Developmental Therapeutics Translational Research Program, Yale Comprehensive Cancer Center, New Haven, Connecticut , USA. Electronic address:

Purpose: To characterize the tumor-infiltrating immune cells population in Kras/p53-driven lung tumors and to evaluate the combinatorial anti-tumor effect with MEK inhibitor (MEKi), trametinib, and immunomodulatory monoclonal antibodies (mAbs) targeting either programmed cell death protein-1 (PD-1) or programmed cell death protein ligand 1 (PD-L1) in vivo.

Experimental Design: Trp53;Kras;Rosa26 (PKL) genetically engineered mice were utilized to develop autochthonous lung tumors with intratracheal delivery of adenoviral Cre recombinase. Using these tumor-bearing lungs, tumor-infiltrating immune cells were characterized by both mass cytometry and flow cytometry. Read More

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http://dx.doi.org/10.1016/j.jtho.2019.02.004DOI Listing
February 2019

Acute and sub-acute toxicity of the aqueous extract from the stem bark of Tetrapleura tetrapteura Taub. (Fabaceae) in mice and rats.

J Ethnopharmacol 2019 Feb 13. Epub 2019 Feb 13.

H.E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan; Department of Biochemistry, Dr. Panjwani Center for Molecular Medicine and Drug Research (P.C.M.D.), International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan. Electronic address:

Ethnopharmacological Relevance: Tetrapleura tetrapteura Taub. is a leguminous multipurpose tree (Fabaceae) indigenous to tropical Africa. Fruits, seeds and stem bark infusions or decoctions of Tetrapleura tetrapteura Taub. Read More

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http://dx.doi.org/10.1016/j.jep.2019.02.026DOI Listing
February 2019

Multiple retrieval case-based reasoning for incomplete datasets.

J Biomed Inform 2019 Feb 13:103127. Epub 2019 Feb 13.

Experimental Radiation Oncology, Department of Radiation Oncology, University Medical Center Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany. Electronic address:

The performance of case-based reasoning (CBR) depends on an accurate ranking of similar cases in the retrieval phase that affects all subsequent phases and profits from the potential of large databases. Unfortunately, growing databases come along with a rising amount of missing data that reduces the stability of the ranking since incomplete cases cannot be ranked as reliable as complete ones. In context of CBR hardly any work was done so far to rigorously analyze the impact of missing data and solutions to tackle this issue. Read More

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http://dx.doi.org/10.1016/j.jbi.2019.103127DOI Listing
February 2019

Optimizing intracellular signaling domains for CAR NK cells in HIV immunotherapy: a comprehensive review.

Drug Discov Today 2019 Feb 13. Epub 2019 Feb 13.

Tulane National Primate Research Center, Tulane University School of Medicine, Covington, LA 70433, USA; Department of Pharmacology, Tulane University School of Medicine, New Orleans, LA 70112, USA. Electronic address:

Natural killer (NK) cells are innate immune lymphocytes with a key role in host defense against HIV infection. Recent advances in chimeric antigen receptors (CARs) have made NK cells a prime target for expressing recombinant receptors capable of redirecting NK cytotoxic functions towards HIV-infected cells. In this review, we discuss the role of NK cells in HIV and the mechanisms of actions of HIV-targeting CAR strategies. Read More

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http://dx.doi.org/10.1016/j.drudis.2019.02.002DOI Listing
February 2019

The representation of symmetry in multi-voxel response patterns and functional connectivity throughout the ventral visual stream.

Neuroimage 2019 Feb 13. Epub 2019 Feb 13.

Brain and Cognition, KU Leuven, Leuven, Belgium; Leuven Brain Institute, KU Leuven, Leuven, Belgium. Electronic address:

Several computational models explain how symmetry might be detected and represented in the human brain. However, while there is an abundance of psychophysical studies on symmetry detection and several neural studies showing where and when symmetry is detected in the brain, important questions remain about how this detection happens and how symmetric patterns are represented. We studied the representation of (vertical) symmetry in regions of the ventral visual stream, using multi-voxel pattern analyses (MVPA) and functional connectivity analyses. Read More

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http://dx.doi.org/10.1016/j.neuroimage.2019.02.030DOI Listing
February 2019

USP39 regulates DNA damage response and chemo-radiation resistance by deubiquitinating and stabilizing CHK2.

Cancer Lett 2019 Feb 13. Epub 2019 Feb 13.

Research Center for Translational Medicine, East Hospital, Tongji University School of Medicine, Shanghai, 200120, China; Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of Medicine, Shanghai, 200120, China. Electronic address:

The serine/threonine kinase, CHK2 (checkpoint kinase 2), is a key mediator in DNA damage response and a tumor suppressor, which is implicated in promoting cell cycle arrest, apoptosis and DNA repair. Accumulating evidence suggests that these functions are primarily exerted through phosphorylation downstream factors such as p53 and BRCA1. Recent studies have shown that ubiquitination is an important mode of regulation of CHK2. Read More

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http://dx.doi.org/10.1016/j.canlet.2019.02.015DOI Listing
February 2019

Caveolin-1 enhances metastasis formation in a human model of embryonal rhabdomyosarcoma through Erk signaling cooperation.

Cancer Lett 2019 Feb 13. Epub 2019 Feb 13.

Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy. Electronic address:

Rhabdomyosarcoma (RMS) is a pediatric soft tissue tumor classified in two major subtypes namely embryonal and alveolar, which have distinctive histopathological and genetic signatures and worse outcomes in the presence of metastases. Here, in order to evaluate the role of Caveolin-1 (Cav-1) in embryonal RMS dissemination, we employed an experimental in vivo metastasis assay using immunodeficient NOD/SCID mice. We found that the intravenous injection of human RD cells engineered for Cav-1 overexpression promoted the formation of lung metastases compared to parental cells. Read More

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http://dx.doi.org/10.1016/j.canlet.2019.02.013DOI Listing
February 2019

A combined immunodeficiency with severe infections, inflammation and allergy caused by ARPC1B deficiency.

J Allergy Clin Immunol 2019 Feb 13. Epub 2019 Feb 13.

Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, Department of Pediatric Immunology, Rheumatology and Infectious diseases, Meibergdreef 9, Amsterdam, The Netherlands; Department of Blood Cell Research, Sanquin Research and Landsteiner Laboratory AMC, University of Amsterdam, The Netherlands. Electronic address:

We report the natural history, clinical manifestations, genetics, and immunohematological findings in 14 patients from 11 families with ARPC1B deficiency, delineating the spectrum of the disease that appears progressive and challenging to manage clinically. Read More

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http://dx.doi.org/10.1016/j.jaci.2019.02.003DOI Listing
February 2019

H NMR characterization of chitin tetrasaccharide in binary HO:DMSO solution: Evidence for anomeric end-effect propagation.

Int J Biol Macromol 2019 Feb 13. Epub 2019 Feb 13.

Department of Chemistry, University of California - Riverside, Riverside, CA 92521, United States. Electronic address:

Chitin oligosaccharides, composed of homogeneous β(1 → 4)-linked N-acetyl-D-glucosamine (GlcNAc) sequences, is a well-known elicitor of plant immune defense, and also occur as structural elements of chitosan and nodulation (Nod) factor. Detailed microstructure characterization is required for understanding the function mode of these bioactive molecules. Herein, experimental conditions for detection and elucidation of the H NMR resonances of amide groups in chitin oligosaccharides are presented. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.02.062DOI Listing
February 2019

The role of type I interferons in CD4 T cell differentiation.

Immunol Lett 2019 Feb 13. Epub 2019 Feb 13.

Division of Immunology, Transplantation and Infectious Diseases and Experimental Imaging Center, IRCCS San Raffaele Scientific Institute and Vita-Salute San Raffaele University, Milan, 20132, Italy. Electronic address:

Type I interferons (IFNs) released upon viral infections play different and opposing roles in disease outcome. This pleiotropic effect is mainly influenced by the cellular sources, timing and target cells for these molecules. The effect of type I IFN signaling on the activation and differentiation of antiviral CD4 T cells remains ill defined, with studies reporting either a beneficial or a detrimental role, depending on the context of infection. Read More

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http://dx.doi.org/10.1016/j.imlet.2019.01.013DOI Listing
February 2019

Effects of Nicotinamide on Spatial Memory and Inflammation After Juvenile Traumatic Brain Injury.

Behav Brain Res 2019 Feb 13. Epub 2019 Feb 13.

Neurotrauma and Rehabilitation Laboratory, Southern Illinois University, Carbondale, IL, United States. Electronic address:

Age is a consistent predictor of outcome following traumatic brain injury (TBI). Although children and adolescents have the highest rate of hospitalizations and long-term disabilities, few preclinical studies have attempted to model and treat TBI in this population. Studies using nicotinamide (NAM), a soluble B-group vitamin, in older animals (3-6 months) have shown improved functional recovery in experimental models of TBI. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.02.024DOI Listing
February 2019

Nitroglycerin as a comparative experimental model of migraine pain: from animal to human and back.

Prog Neurobiol 2019 Feb 13. Epub 2019 Feb 13.

Headache Science Center, IRCCS C. Mondino Foundation, Pavia, Italy; Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy. Electronic address:

Migraine is a disease for which there is still no defined pathophysiological etiology and few translational models. The organic nitrate nitroglycerin has been in use as an experimental model of migraine in both human and animal studies for several years. The drug produces a number of effects within the head, that includes blood vessels, nerves and brain areas that may produce a response similar to a migraine attack in predisposed subjects. Read More

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http://dx.doi.org/10.1016/j.pneurobio.2019.02.002DOI Listing
February 2019

Progenesis and facultative life cycle abbreviation in trematode parasites: are there more constraints than costs?

Int J Parasitol 2019 Feb 13. Epub 2019 Feb 13.

Department of Biological Sciences, University of Alberta, Edmonton T6G 2E9, Alberta, Canada. Electronic address:

Complex life cycles provide advantages to parasites (longer life span, higher fecundity, etc.), but also represent a series of unlikely events for which many adaptations have evolved (asexual multiplication, host finding mechanisms, etc.). Read More

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http://dx.doi.org/10.1016/j.ijpara.2018.11.009DOI Listing
February 2019

Pitolisant and intravenous cocaine self-administration in mice.

Eur J Pharmacol 2019 Feb 13. Epub 2019 Feb 13.

Département de Psychologie, Cognition et Comportement, Université de Liège, Place des Orateurs, 2/B-32, Liège, Belgium.

Pitolisant, a selective inverse agonist for the histamine H3 receptor, is a new treatment for adults suffering from narcolepsy. Numerous studies have shown that striatal H3 receptors can modulate the activity of the dopamine mesolimbic system, a pathway that plays a crucial role in drug addiction. Therefore, it is important to guarantee that pitolisant has no abuse potential and does not potentiate the behavioral effects of psychostimulants. Read More

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http://dx.doi.org/10.1016/j.ejphar.2019.02.019DOI Listing
February 2019

Immunoglobulin G4 Inflammatory Aortic Aneurysm Mimicking Acute Aortic Syndrome.

Ann Thorac Surg 2019 Feb 13. Epub 2019 Feb 13.

Department of Orthopedics and Trauma - Surgery, Division of Trauma - Surgery, General Hospital of Vienna, Austria.

Immunoglobulin-G4-related disease (IgG4RD) is a novel clinical entity characterized by lymphoplasmacytic infiltrates presenting as an excessive fibrosis such as retroperitoneal inflammatory pseudotumor but rarely affecting the heart or the aorta. We describe a case of IgG4RD with multifocal aortic involvement presenting as an acute aortic syndrome. Read More

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http://dx.doi.org/10.1016/j.athoracsur.2019.01.029DOI Listing
February 2019

Identification of mineralocorticoid and glucocorticoid receptors on peripheral nociceptors: translation of experimental findings from animal to human biology.

Brain Res 2019 Feb 13. Epub 2019 Feb 13.

Charité - Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Anaesthesiology and Intensive Care Medicine, Charité University Berlin, Campus Virchow Klinikum, Berlin, Germany.

Evidence is accumulating that activation of mineralocorticoid (MR) and glucocorticoid (GR) receptors on peripheral sensory neurons modulates pain sensation. While the expression and exact anatomical localization of MR and GR in the various subpopulations of peripheral sensory neurons has been shown in animals, it is still unknown for the human skin. Therefore, we aimed to identify MR and GR mRNA and protein as well as the exact subpopulations of sensory neurons in human versus rat skin. Read More

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http://dx.doi.org/10.1016/j.brainres.2019.02.015DOI Listing
February 2019

Interventions for the control of Aedes aegypti in Latin America and the Caribbean: Systematic Review and Meta-Analysis.

Trop Med Int Health 2019 Feb 16. Epub 2019 Feb 16.

Instituto de Efectividad Clínica y Sanitaria, Centro de Investigación de Epidemiología y Salud Pública, Argentina.

Objective: To determine the effectiveness and degree of implementation of interventions for the control of Aedes aegypti in Latin America and the Caribbean (LAC) as reported in scientific literature.

Methods: We searched MEDLINE, EMBASE, CENTRAL, SOCINDEX and LILACS, for experimental and observational studies, economic assessments and qualitative experiences carried out in LAC from 2000 to 2016. We assessed incidence and morbimortality of Aedes aegypti-related diseases and entomological indices: Breteau (containers), House, and Pupae per Person. Read More

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http://dx.doi.org/10.1111/tmi.13217DOI Listing
February 2019

Placental Growth Factor Blunts Uterine Artery Responses to Angiotensin II.

BJOG 2019 Feb 16. Epub 2019 Feb 16.

Department of Obstetrics and Gynecology, Baylor College of Medicine and Texas Children's Hospital-Pavilion for Women, Houston, TX, United States.

Objective: Changes in maternal serum concentration of placental growth factor (PlGF) and vascular response to intravascular infusion of Angiotensin II (Ang II) follow a bell-shaped curve pattern during gestation. This study evaluates the effects of PlGF and soluble vascular endothelial growth factor receptor-1 (sFlt-1) on responses of human uterine arteries (UA) to Ang II.

Design: Experimental. Read More

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http://dx.doi.org/10.1111/1471-0528.15656DOI Listing
February 2019

Disruption of gene SPL35, encoding a novel CUE domain-containing protein, leads to cell death and enhanced disease response in rice.

Plant Biotechnol J 2019 Feb 16. Epub 2019 Feb 16.

Institute of Crop Sciences, Chinese Academy of Agricultural Sciences/ National Key Facility for Crop Gene Resources and Genetic Improvement, Beijing, 100081, China.

Lesion mimic mutants that exhibit spontaneous hypersensitive response (HR)-like necrotic lesions are ideal experimental systems for elucidating molecular mechanisms involved in plant cell death and defense responses. Here we report identification of a rice lesion mimic mutant, spotted leaf 35 (spl35), and cloning of the causal gene by TAIL-PCR strategy. spl35 exhibited decreased chlorophyll content, higher accumulation of H O , up-regulated expression of defense-related marker genes, and enhanced resistance to both fungal and bacterial pathogens of rice. Read More

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http://dx.doi.org/10.1111/pbi.13093DOI Listing
February 2019

Weak effects of geolocators on small birds: a meta-analysis controlled for phylogeny and publication bias.

J Anim Ecol 2019 Feb 16. Epub 2019 Feb 16.

The Czech Academy of Sciences, Institute of Vertebrate Biology, Květná 8, 603 65, Brno, Czech Republic.

Currently, the deployment of tracking devices is one of the most frequently used approaches to study movement ecology of birds. Recent miniaturisation of light-level geolocators enabled studying small bird species whose migratory patterns were widely unknown. However, geolocators may reduce vital rates in tagged birds and may bias obtained movement data. Read More

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http://dx.doi.org/10.1111/1365-2656.12962DOI Listing
February 2019

Early maladaptive schemas and borderline personality disorder features in a non-clinical sample: A network analysis.

Clin Psychol Psychother 2019 Feb 16. Epub 2019 Feb 16.

Department of Experimental, Clinical and Health Psychology, Ghent University, Ghent, Belgium.

Borderline personality disorder (BPD) is a challenging problem. Early Maladaptive Schema (EMSs) are considered as important vulnerability factors for the development and maintenance of BPD. Literature suggests a complex relationship between BPD and EMSs. Read More

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http://dx.doi.org/10.1002/cpp.2360DOI Listing
February 2019

Focal spleen lesions in visceral leishmaniasis, a neglected manifestation of a neglected disease: report of three cases and systematic review of literature.

Infection 2019 Feb 15. Epub 2019 Feb 15.

Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.

Background: The Mediterranean area is endemic for the zoonotic form of visceral leishmaniasis (VL) caused by Leishmania infantum, a species which has been recently associated with unexpected epidemiological and clinical features.

Method: We report the result of a systematic review of the literature on VL unusually presenting with spleen focal lesions, including three previously unpublished cases.

Results: A total of 28 cases of VL with multiple spleen focal lesions were retrieved. Read More

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http://dx.doi.org/10.1007/s15010-019-01279-5DOI Listing
February 2019

Simultaneous Isolation of Stem and Niche Cells of Skeletal Muscle: Applicability for Aging Studies.

Methods Mol Biol 2019 Feb 16. Epub 2019 Feb 16.

Cell Biology Group, Department of Experimental and Health Sciences, Pompeu Fabra University (UPF), CIBER on Neurodegenerative Diseases (CIBERNED), Barcelona, Spain.

The maintenance of adult stem cells in their normal quiescent state depends on intrinsic factors and extrinsic signals originating from their microenvironment (also known as the stem cell niche). In skeletal muscle, its stem cells (satellite cells) lose their regenerative potential with aging, and this has been attributed, at least in part, to both age-associated changes in the satellite cells as in the niche cells, which include resident fibro-adipogenic progenitors (FAPs), macrophages, and endothelial cells, among others. To understand the regenerative decline of skeletal muscle with aging, there is a need for methods to specifically isolate stem and niche cells from resting muscle. Read More

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http://dx.doi.org/10.1007/7651_2019_210DOI Listing
February 2019

Probing Alpha-Synuclein Conformations by Electron Paramagnetic Resonance (EPR) Spectroscopy.

Methods Mol Biol 2019 ;1948:247-260

Department of Chemistry and Konstanz Research School Chemical Biology, University of Konstanz, Konstanz, Germany.

Electron paramagnetic resonance (EPR) spectroscopy in combination with site-directed spin labeling is ideally suited to study structure, dynamics, and interactions of intrinsically disordered proteins as alpha-synuclein.Here we describe all steps required for a corresponding study: the spin labeling procedure, sample preparation, spectroscopic experimental procedure, and data analysis. Read More

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http://dx.doi.org/10.1007/978-1-4939-9124-2_19DOI Listing
January 2019

Yeast-Based Screens to Target Alpha-Synuclein Toxicity.

Methods Mol Biol 2019 ;1948:145-156

Department of Experimental Neurodegeneration, Center for Biostructural Imaging of Neurodegeneration, University Medical Center Goettingen, Goettingen, Germany.

The budding yeast Saccharomyces cerevisiae (S. cerevisiae) has been a remarkable experimental model for the discovery of fundamental biological processes. The high degree of conservation of cellular and molecular processes between the budding yeast and higher eukaryotes has made it a valuable system for the investigation of the molecular mechanisms behind various types of devastating human pathologies. Read More

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http://dx.doi.org/10.1007/978-1-4939-9124-2_12DOI Listing
January 2019

Stereotaxic Targeting of Alpha-Synuclein Pathology in Mouse Brain Using Preformed Fibrils.

Methods Mol Biol 2019 ;1948:45-57

Center for Neurodegenerative Disease Research, Institute on Aging, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

The accumulation of intraneuronal inclusions containing misfolded alpha-synuclein (aSyn) within the central nervous system (CNS) is a common feature found in several neurodegenerative disorders including Parkinson's disease (PD). Emerging evidence indicates that aSyn amyloid fibrils, a configuration that is present within these characteristic inclusions, are capable of self-replicating by templating the conversion of endogenously expressed aSyn in neurons. Stereotaxic administration of synthetic α-synuclein preformed fibrils (PFFs) into the mouse brain has been shown to seed the formation of intracellular aSyn pathology reminiscent of Lewy body (LB) inclusions present in human PD and related synucleinopathies. Read More

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http://dx.doi.org/10.1007/978-1-4939-9124-2_5DOI Listing
January 2019

Assays for Neuronal Defects Caused by Early Formation of α-Synuclein Inclusions in Primary Cultured Neurons.

Methods Mol Biol 2019 ;1948:1-14

Department of Neurology, Center for Neurodegeneration and Experimental Therapeutics, University of Alabama at Birmingham, Birmingham, AL, USA.

Parkinson's disease (PD) and dementia with Lewy bodies (DLB) are characterized by intracellular inclusions composed mostly of α-synuclein (Baba et al., Am J Pathol 152:879-884, 1998). How inclusion formation impacts neuronal function prior to death is key to understanding disease progression and identifying therapeutic windows. Read More

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http://dx.doi.org/10.1007/978-1-4939-9124-2_1DOI Listing
January 2019

A novel nano zero-valent iron biomaterial for chromium (Cr to Cr) reduction.

Environ Sci Pollut Res Int 2019 Feb 15. Epub 2019 Feb 15.

Department of Chemical Engineering, Indian Institute of Technology Roorkee, Roorkee, Uttarakhand, 247 667, India.

This research work aims to develop a biomaterial entrapped with iron nanoparticles by green synthesis method in which biomass act as both reducing and capping agent. Iron nanoparticles embedded in Citrus limetta peels were characterised using ICP-MS for determination of metal loading, XRD, XPS for crystallinity and oxidation states, TEM followed by FESEM-EDS for particle size and morphology. Sizes of nanoparticles were found to be in the range of 4-70 nm. Read More

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http://dx.doi.org/10.1007/s11356-019-04528-0DOI Listing
February 2019

Regional pulmonary effects of bronchoalveolar lavage procedure determined by electrical impedance tomography.

Intensive Care Med Exp 2019 Feb 15;7(1):11. Epub 2019 Feb 15.

Pediatric and Neonatal Intensive Care Unit, Children's Hospital, University of Geneva, Geneva, Switzerland.

Background: The provision of guidance in ventilator therapy by continuous monitoring of regional lung ventilation, aeration and respiratory system mechanics is the main clinical benefit of electrical impedance tomography (EIT). A new application was recently described in critically ill patients undergoing diagnostic bronchoalveolar lavage (BAL) with the intention of using EIT to identify the region where sampling was performed. Increased electrical bioimpedance was reported after fluid instillation. Read More

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http://dx.doi.org/10.1186/s40635-019-0225-6DOI Listing
February 2019

SERS-based chip for discrimination of formaldehyde and acetaldehyde in aqueous solution using silver reduction.

Mikrochim Acta 2019 Feb 15;186(3):175. Epub 2019 Feb 15.

Shanghai Key Laboratory of Functional & School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai, 200237, People's Republic of China.

A method is described for surface-enhanced Raman scattering (SERS) discrimination of formaldehyde (FA) and acetaldehyde (AA) in aqueous sample solutions. It is based on the use of a paper strip containing 4-aminothiophenol (Atp)-modified reduced graphene oxide (rGO)/[Ag(NH)] (rGO/[Ag(NH)]/Atp). The addition of FA or AA induces the conversion of [Ag(NH)] complex to silver nanoparticles (AgNPs) because of aldehyde-induced silver reduction reaction. Read More

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http://dx.doi.org/10.1007/s00604-019-3305-0DOI Listing
February 2019

Determination of alkaline phosphatase activity based on enzyme-triggered generation of a thiol and the fluorescence quenching of silver nanoclusters.

Mikrochim Acta 2019 Feb 15;186(3):180. Epub 2019 Feb 15.

The Key Lab of Health Chemistry and Molecular Diagnosis of Suzhou, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, 199 Ren'ai Road, Industrial Park, Suzhou, 215123, China.

A fluorimetric method is described for the determination of alkaline phosphatase (ALP) activity. It is based on the use of polyethyleneimine-coated silver nanoclusters (AgNCs), which display an intense blue fluorescence peaking at 450 nm (under 375 nm excitation). ALP catalyzes the dephosphorylation of the thiophosphate amifostine to generate a thiol that binds to the AgNCs and causes its fluorescence to be quenched. Read More

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http://dx.doi.org/10.1007/s00604-019-3301-4DOI Listing
February 2019

Stomaching Acute Brain Injury.

Neurocrit Care 2019 Feb 15. Epub 2019 Feb 15.

Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.

Gastrointestinal complications, including hemorrhage, can occur with intracranial lesions and after craniotomy. As early as the 19th century, surgeons were aware that brain tumors could cause gastric ulcers and acute perforations. Investigators used animal experiments both to reproduce these clinical observations and to seek ways to block the effects. Read More

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http://dx.doi.org/10.1007/s12028-019-00685-9DOI Listing
February 2019

A process account of the uncontrolled manifold structure of joint space variance in pointing movements.

Biol Cybern 2019 Feb 15. Epub 2019 Feb 15.

Institute for Neural Computation, Ruhr-University, Bochum, Germany.

In many situations, the human movement system has more degrees of freedom than needed to achieve a given movement task. Martin et al. (Neural Comput 21(5):1371-1414, 2009) accounted for signatures of such redundancy like self-motion and motor equivalence in a process model in which a neural oscillator generated timed end-effector virtual trajectories that a neural dynamics transformed into joint virtual trajectories while decoupling task-relevant and task-irrelevant combinations of joint angles. Read More

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http://dx.doi.org/10.1007/s00422-019-00794-wDOI Listing
February 2019

Safety first: significant risk of air embolism in laparoscopic gasketless insufflation systems.

Surg Endosc 2019 Feb 15. Epub 2019 Feb 15.

Department of Surgery, St. Luke's Regional Medical Center, Boise, ID, USA.

Background: Gasketless laparoscopic insufflator systems are marketed for the ability to prevent desufflation of pneumoperitoneum during laparoscopy. However, surgeons raised concern for possible introduction of non-absorbable room air, including oxygen (O), with these systems. A community-university collaborative was created to test this hypothesis. Read More

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http://dx.doi.org/10.1007/s00464-019-06683-4DOI Listing
February 2019
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