1,443,150 results match your criteria Experimental biology and medicine Maywood N.J.[Journal]


Quantitative analysis of the yeast pheromone pathway.

Yeast 2019 Apr 25. Epub 2019 Apr 25.

Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.

The pheromone response pathway of the yeast S. cerevisiae is a well-established model for the study of G proteins and mitogen-activated protein kinase (MAPK) cascades. Our longstanding ability to combine sophisticated genetic approaches with established functional assays has provided a thorough understanding of signaling mechanisms and regulation. Read More

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http://dx.doi.org/10.1002/yea.3395DOI Listing
April 2019
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1.634 Impact Factor

Artificial Intelligence in Primary Health Care: Perceptions, Issues, and Challenges.

Yearb Med Inform 2019 Apr 25. Epub 2019 Apr 25.

Department of Clinical & Experimental Medicine, University of Surrey, Guildford, Surrey, UK.

Background: Artificial intelligence (AI) is heralded as an approach that might augment or substitute for the limited processing power of the human brain of primary health care (PHC) professionals. However, there are concerns that AI-mediated decisions may be hard to validate and challenge, or may result in rogue decisions.

Objective: To form consensus about perceptions, issues, and challenges of AI in primary care. Read More

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http://dx.doi.org/10.1055/s-0039-1677901DOI Listing

Peptide-Binding Groove Contraction Linked to the Lack of T Cell Response: Using Complex Structure and Energy To Identify Neoantigens.

Immunohorizons 2018 Aug 10;2(7):216-225. Epub 2018 Aug 10.

Department of Immunology, Mayo Clinic, Rochester, MN 55905; and.

Using personalized peptide vaccines (PPVs) to target tumor-specific nonself-antigens (neoantigens) is a promising approach to cancer treatment. However, the development of PPVs is hindered by the challenge of identifying tumor-specific neoantigens, in part because current in silico methods for identifying such neoantigens have limited effectiveness. In this article, we report the results of molecular dynamics simulations of 12 oligopeptides bound with an HLA, revealing a previously unrecognized association between the inability of an oligopeptide to elicit a T cell response and the contraction of the peptide-binding groove upon binding of the oligopeptide to the HLA. Read More

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http://dx.doi.org/10.4049/immunohorizons.1800048DOI Listing

Gender- and age-dependencies of oxidative stress, as detected based on the steady state concentrations of different biomarkers in the MARK-AGE study.

Redox Biol 2019 Apr 15;24:101204. Epub 2019 Apr 15.

Department of Physiology and Pharmacology, Sackler Medical School, Tel Aviv University, Tel Aviv, Israel. Electronic address:

Recently, Weber et al. published a thorough investigation of the age-dependency of oxidative stress (OS) determined by the steady state concentrations of different compounds - oxidation products and antioxidants - that are in common use as biomarkers of OS in 2207 healthy individuals of the cross-sectional MARK-AGE Project. The correlations among biomarkers were significant but weak. Read More

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http://dx.doi.org/10.1016/j.redox.2019.101204DOI Listing

In vitro, in cellulo and structural characterizations of the interaction between the integrase of Porcine Endogenous Retrovirus A/C and proteins of the BET family.

Virology 2019 Apr 16;532:69-81. Epub 2019 Apr 16.

INRA, Université Lyon 1, UMR754, Viral Infections Compared Pathology, 69007, Lyon, France; Université de Lyon, 69000, Lyon, France; UMSl3444 Biosciences Gerland Lyon Sud, 69007, Lyon, France. Electronic address:

Retroviral integrase (IN) proteins catalyze the permanent integration of the viral genome into host DNA. They can productively recruit cellular proteins, and the human Bromodomain and Extra-Terminal domain (hBET) proteins have been shown to be co-factors for integration of gamma-retroviruses such as Murine Leukemia Virus (MLV) into human cells. By using two-hybrid, co-immunoprecipitation and in vitro interaction assays, we showed that IN of the gamma- Porcine Endogenous Retrovirus-A/C (PERV IN) interacts through its C-terminal domain (CTD) with hBET proteins. Read More

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http://dx.doi.org/10.1016/j.virol.2019.04.002DOI Listing

Comparative transcriptomics analysis of potassium uptake pathways mediated cesium accumulation differences and related molecular mechanisms in Brassica juncea and Vicia faba.

Ecotoxicol Environ Saf 2019 Apr 22;179:31-39. Epub 2019 Apr 22.

Engineering Research Center of Biomass Materials, Ministry of Education, Southwest University of Science and Technology, Mianyang, 621010, China; School of Life Science and Engineering, Southwest University of Science and Technology, Mianyang, 621010, China. Electronic address:

To analyze the differences between high- and low-accumulation plants in cesium (Cs) uptake and its related mechanism, Brassica juncea (a hyperaccumulation plant for Cs) and Vicia faba (a low-accumulation plant for Cs) were selected as comparative experimental materials. The contributions to Cs uptake of a K-transporter-mediated high-affinity transport system and a K-channel-mediated low-affinity transport system in the two plants were compared and analyzed. The difference between the two plants in the mechanism of Cs uptake was further analyzed using transcription sequence technology. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2019.04.043DOI Listing

Synergetic effects of novel aromatic brominated and chlorinated disinfection byproducts on Vibrio qinghaiensis sp.-Q67.

Environ Pollut 2019 Apr 14;250:375-385. Epub 2019 Apr 14.

College of Environmental Science and Engineering, Guilin University of Technology, Guilin, 541004, China; Guangxi Key Laboratory of Environmental Pollution Control Theory and Technology, Guilin University of Technology, Guilin, 541004, China; Collaborative Innovation Center for Water Pollution Control and Water Safety in Karst Area, Guilin University of Technology, Guili, 541004, China.

Aromatic halogenated chemicals are an unregulated class of byproducts (DBPs) generated from disinfection processes in the water environment. Information on the toxicological interactions, such as antagonism and synergism, present in DBP mixtures remains limited. This study aimed to determine the toxicological effects of aromatic halogenated DBP mixtures on the freshwater bacterium Vibrio qinghaiensis sp. Read More

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http://dx.doi.org/10.1016/j.envpol.2019.04.009DOI Listing

Brainstem biopsy in pediatric diffuse intrinsic pontine glioma in the era of precision medicine: the INFORM study experience.

Eur J Cancer 2019 Apr 22;114:27-35. Epub 2019 Apr 22.

Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany; Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, Heidelberg, Germany; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany. Electronic address:

Purpose: Diffuse intrinsic pontine glioma (DIPG) is a highly aggressive paediatric brain tumour with fatal outcome. The Individualised Therapy For Relapsed Malignancies In Childhood (INFORM) registry study offers comprehensive molecular profiling of high-risk tumours to identify target alterations for potential precision therapy. We analysed molecular characteristics and clinical data after brainstem biopsy of all enrolled newly diagnosed DIPGs. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09598049193022
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http://dx.doi.org/10.1016/j.ejca.2019.03.019DOI Listing
April 2019
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Glycogen synthase kinase-3 inhibition as a potential pharmacological target for vascular dementia: In silico and in vivo evidence.

Comput Biol Med 2019 Mar 16;108:305-316. Epub 2019 Mar 16.

Department of Pharmaceutical Sciences & Drug Research, Punjabi University, Patiala, India. Electronic address:

Vascular dementia is a serious problem as it creates significant disability and dependency in the affected person. Lives of these patients can be improved through the advent of novel drug targets which can be targeted by pharmacological therapies. However, finding a precise and druggable target for vascular dementia is experimentally impossible and challenging task owing to a complex and mostly unknown interplay between the cognitive abilities of the brain with a diversity of vascular diseases. Read More

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http://dx.doi.org/10.1016/j.compbiomed.2019.03.002DOI Listing

The stability of different housekeeping genes in human periodontal ligament cells under inflammatory conditions.

Ann Anat 2019 Apr 22. Epub 2019 Apr 22.

Department of Orthodontics, University of Bonn, Medical Faculty, Bonn 53111, Germany. Electronic address:

Purpose: Stability of housekeeping genes as internal reference for RT-qPCR analyses is mandatory for a correct interpretation of results. As no normalization benchmark exists and reference gene va-lidation is highly specific for individual experiments, it was the purpose of this study to identify stable candidates for investigations on periodontal inflammation.

Basic Procedures: Human PDL cells from one cell line (Lonza) and three primary donors were challenged with IL-1ß (5 ng/ml) or centrifugation (170 x g) for six hours under serum-free conditions. Read More

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http://dx.doi.org/10.1016/j.aanat.2019.04.001DOI Listing

Genome-wide and functional analyses of tyrosine kinase-like family genes reveal potential roles in development and virulence in mosquito pathogen Pythium guiyangense.

Fungal Genet Biol 2019 Apr 22. Epub 2019 Apr 22.

Department of Entomology, Nanjing Agricultural University, Nanjing, China. Electronic address:

The tyrosine kinase-like (TKL) gene family is widely existed in most eukaryotes and participates in many biological processes, however, has been rarely studied in oomycetes. In this study we performed bioinformatic and experimental analyses to characterize TKLs in Pythium guiyangense, a promising mosquito biological control agent. Our results revealed that TKLs were widely distributed in all the detected oomycetes, but were largely expanded in P. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10871845183032
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http://dx.doi.org/10.1016/j.fgb.2019.04.009DOI Listing
April 2019
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Exposure to carbon black nanoparticles during pregnancy persistently damages the cerebrovascular function in female mice.

Toxicology 2019 Apr 22. Epub 2019 Apr 22.

Department of Occupational and Environmental Health, School of Public Health and Management, Research Center for Medicine and Social Development, Innovation Center for Social Risk Governance in Health, Chongqing Medical University, Chongqing, 400016, People's Republic of China; Post-doctoral Research Stations of Nursing Science, School of Nursing, Chongqing Medical University, Chongqing, 400016, People's Republic of China. Electronic address:

Maternal exposure to carbon black nanoparticles (CBNPs) during pregnancy have been well documented to induce harmful outcomes of offspring on brain function. However, it remains largely unknown whether females exposed to CBNPs during sensitive period of pregnancy can cause the neurotoxic effects on their own body after parturition. In this study, our results showed that pregnancy CBNPs exposure induced the persistent pathological changes in the cerebral cortex tissues and impaired cerebrovascular function of mice manifested by significant alterations of endothelin-1, endothelial nitric oxide synthase, vascular endothelial growth factor-A and ATP-binding cassette transporter G1. Read More

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http://dx.doi.org/10.1016/j.tox.2019.04.014DOI Listing

Stress changes amphetamine response, D2 receptor expression and epigenetic regulation in low-anxiety rats.

Prog Neuropsychopharmacol Biol Psychiatry 2019 Apr 22. Epub 2019 Apr 22.

Department of Neurochemistry, Institute of Psychiatry and Neurology, 9 Sobieskiego Street, 02-957 Warsaw, Poland.

The aim of this study was to assess the influence of chronic restraint stress on amphetamine (AMPH)-related appetitive 50-kHz ultrasonic vocalisations (USVs) in rats differing in freezing duration in a contextual fear test (CFT), i.e. HR (high-anxiety responsive) and LR (low-anxiety responsive) rats. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02785846183097
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http://dx.doi.org/10.1016/j.pnpbp.2019.04.009DOI Listing
April 2019
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Enhancing effect of cystamine in its amides with betulinic acid as antimicrobial and antitumor agent in vitro.

Steroids 2019 Apr 22. Epub 2019 Apr 22.

University of Chemistry and Technology, Department of Chemistry of Natural Compounds, Technická 5, 166 28 Prague 6, Czech Republic; Institute of Experimental Botany AS CR, v.v.i., Isotope Laboratory, Vídeňská 1083, 142 20, Prague 4, Czech Republic. Electronic address:

Amides of betulinic acid with cystamine were synthesized to investigate their antimicrobial and antitumor activity, and their influence on the cell cycle and cell apoptosis. The former target amide (6) displayed cytotoxicity in CEM cell line after 72 h of treatment (IC = 3.0 ± 0. Read More

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http://dx.doi.org/10.1016/j.steroids.2019.04.004DOI Listing

Antiadipogenic effects of açai seed extract on high fat diet-fed mice and 3T3-L1 adipocytes: A potential mechanism of action.

Life Sci 2019 Apr 22. Epub 2019 Apr 22.

Laboratory for Studies of Interactions Between Nutrition and Genetics, LEING, Department of Basic and Experimental Nutrition, Rio de Janeiro State University, Rio de Janeiro, Brazil. Electronic address:

Body adiposity is an important risk factor for the development of chronic non-transmissible diseases. Studies on the process of adipogenesis have been extensively performed in vivo and in vitro models to describe the molecular and cellular bases of adipose tissue development and the effect of natural products in this process. The açai seed extract (ASE) has been evidenced as a potential regulator of body mass. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.04.051DOI Listing

Integrated immunochromatographic assay for qualitative and quantitative detection of clenbuterol.

Anal Biochem 2019 Apr 22. Epub 2019 Apr 22.

State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, 330047, China. Electronic address:

In this study, colloidal gold (CG) and time-resolved fluorescent nanobead (TRFN) probes were used to establish an integrated immunochromatographic assay (ICA) to qualitatively and quantitatively detect clenbuterol (CLE). The best experimental conditions for the two probes in separate ICAs were obtained by optimizing the antibody labeling concentration, the amount of antigen, and the concentration of probe. When the CG and TRFN probes co-existed in the ICA, the latter had no effect on the sensitivity of qualitative detection of the CG probe-based ICA. Read More

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http://dx.doi.org/10.1016/j.ab.2019.04.013DOI Listing

Critical appraisal of STAT3 pattern in adult cardiomyocytes.

J Mol Cell Cardiol 2019 Apr 22. Epub 2019 Apr 22.

Univ-Lyon, CarMeN Laboratory, INSERM 1060, INRA 1397, University Claude Bernard Lyon1, INSA Lyon, Oullins, France; IHU OPeRa, Groupement Hospitalier EST, Bâtiment B13, 59 boulevard Pinel, F-69500 Bron, France. Electronic address:

The signal transducer and activator of transcription 3, STAT3, transfers cellular signals from the plasma membrane to the nucleus, acting as a signaling molecule and a transcription factor. Reports proposed an additional n-canical role of STAT3 that could regulate the activity of complexes I and II of the electron transport chain and the opening of the mitochondrial permeability transition pore (PTP) after ischemia-reperfusion in various cell types. The native expression of STAT3 in heart mitochondria, together with a direct versus an indirect transcriptional role in mitochondrial functions, have been recently questioned. Read More

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http://dx.doi.org/10.1016/j.yjmcc.2019.04.021DOI Listing

Emerging therapeutic strategies for transplantation-induced acute kidney injury: protecting the organelles and the vascular bed.

Expert Opin Ther Targets 2019 Apr 25. Epub 2019 Apr 25.

b Inserm U1082 , Poitiers , F-86000 , France.

Introduction: Renal ischemia-reperfusion injury (IRI) is a significant clinical challenge faced by clinicians in a broad variety of clinical settings such as perioperative and intensive care. Renal IRI induced acute kidney injury (AKI) is a global public health concern associated with high morbidity, mortality, and healthcare costs. Areas covered: This paper focuses on the pathophysiology of transplantation-related AKI and recent findings on cellular stress responses at the intersection of 1. Read More

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http://dx.doi.org/10.1080/14728222.2019.1609451DOI Listing

The effects of vitamins and selenium mixture against brain tissue induced by d-galactosamine.

J Biochem Mol Toxicol 2019 Apr 25:e22347. Epub 2019 Apr 25.

Department of Chemistry, Faculty of Engineering, Istanbul University-Cerrahpasa, Istanbul, Turkey.

Brain damage is a major complication of fulminant hepatic failure. d-Galactosamine (d-GalN)-induced liver toxicity causes damage to brain. The effects of vitamins and selenium mixture against d-GalN stimulated brain injury were investigated in this study. Read More

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http://dx.doi.org/10.1002/jbt.22347DOI Listing

Propensity to sell stocks in an artificial stock market.

PLoS One 2019 25;14(4):e0215685. Epub 2019 Apr 25.

Department of Economics, Federal University of Santa Catarina, Florianopolis, Brazil.

This experimental study of an artificial stock market investigates what explains the propensity to sell stocks and thus the disposition effect. It is a framed field experiment that follows the steps of a previous observational study of investor behavior in the Finnish stock market. Our experimental approach has an edge over the observational study in that it can control extraneous variables and two or more groups can be compared. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215685PLOS
April 2019
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A geometric calibration method for the digital chest tomosynthesis with dual-axis scanning geometry.

PLoS One 2019 25;14(4):e0216054. Epub 2019 Apr 25.

Health Physics Division, Institute of Nuclear Energy Research, Atomic Energy Council, Taoyuan, Taiwan.

The aim of this study was to develop a geometric calibration method capable of eliminating the reconstruction artifacts of geometric misalignments in a tomosynthesis prototype with dual-axis scanning geometry. The potential scenarios of geometric misalignments were demonstrated, and their effects on reconstructed images were also evaluated. This method was a phantom-based approach with iterative optimization, and the calibration phantom was designed for specific tomosynthesis scanning geometry. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0216054PLOS
April 2019
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Aerobic exercise training prevents obesity and insulin resistance independent of the renin angiotensin system modulation in the subcutaneous white adipose tissue.

PLoS One 2019 25;14(4):e0215896. Epub 2019 Apr 25.

School of Arts, Science and Humanities, University of Sao Paulo, São Paulo, Brazil.

We investigate the effects of aerobic exercise training (AET) on the thermogenic response, substrate metabolism and renin angiotensin system (RAS) in the subcutaneous white adipose tissue (SC-WAT) of mice fed cafeteria diet (CAF). Male C57BL/6J mice were assigned into groups CHOW-SED (chow diet, sedentary; n = 10), CHOW-TR (chow diet, trained; n = 10), CAF-SED (CAF, sedentary; n = 10) and CAF-TR (CAF, trained; n = 10). AET consisted in running sessions of 60 min at 60% of maximal speed, five days per week for eight weeks. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215896PLOS

Cephalometric studies of the mandible, its masticatory muscles and vasculature of growing Göttingen Minipigs-A comparative anatomical study to refine experimental mandibular surgery.

PLoS One 2019 25;14(4):e0215875. Epub 2019 Apr 25.

Institute of Veterinary Anatomy, Department of Veterinary Medicine, Freie Universität Berlin, Berlin, Germany.

Over many decades, the Göttingen Minipig has been used as a large animal model in experimental surgical research of the mandible. Recently several authors have raised concerns over the use of the Göttingen Minipig in this research area, observing problems with post-operative wound healing and loosening implants. To reduce these complications during and after surgery and to improve animal welfare in mandibular surgery research, the present study elucidated how comparable the mandible of minipigs is to that of humans and whether these complications could be caused by specific anatomical characteristics of the minipigs' mandible, its masticatory muscles and associated vasculature. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215875PLOS

Anomaly detection over differential preserved privacy in online social networks.

PLoS One 2019 25;14(4):e0215856. Epub 2019 Apr 25.

Computer Science Department, King Saud University, Riyadh, Kingdom of Saudi Arabia.

The massive reach of social networks (SNs) has hidden their potential concerns, primarily those related to information privacy. Users increasingly rely on social networks for more than merely interactions and self-representation. However, social networking environments are not free of risks. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215856PLOS

Achieving optimal best practice: An inquiry into its nature and characteristics.

PLoS One 2019 25;14(4):e0215732. Epub 2019 Apr 25.

Department of Industrial Engineering and Management Information, Huafan University, New Taipei City, Taiwan.

The study of optimal best practice within the context of academia has produced both empirical and theoretical contributions. Optimal best practice, also coined as optimal functioning, is concerned with a person's personal best-that is, "what is the best that I can do for this academic subject?" Research in the social sciences has, to date, explored different types of optimal best-physical, cognitive, emotional, and social. What is of considerable interest, as a related matter, is a question of how a person reaches and experiences a level of optimal best practice. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215732PLOS

Electrolyte imbalances in an unselected population in an emergency department: A retrospective cohort study.

PLoS One 2019 25;14(4):e0215673. Epub 2019 Apr 25.

Department of Internal Medicine, Diakonhjemmet Hospital, Oslo, Norway.

Background: Although electrolyte imbalances (EIs) are common in the emergency department (ED), few studies have examined the occurrence of such conditions in an unselected population.

Objectives: To investigate the frequency of EI among adult patients who present to the ED, with regards to type and severity, and the association with age and sex of the patient, hospital length of stay (LOS), readmission, and mortality.

Methods: A retrospective cohort study. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215673PLOS

Evaluation of enterotoxin gene expression and enterotoxin production capacity of the probiotic strain Bacillus toyonensis BCT-7112T.

PLoS One 2019 25;14(4):e0214536. Epub 2019 Apr 25.

Department of Physiology, University of Veterinary Medicine Hannover, Foundation, Hannover, Germany.

The aim of the present study was to evaluate the safety of the probiotic strain Bacillus toyonensis BCT-7112T (active ingredient of Toyocerin) in relation to the enterotoxins haemolysin BL (Hbl) and the non-haemolytic enterotoxin (Nhe) by performing a quantitative reverse transcription (RT) real-time polymerase chain reaction (PCR) and a Western blot assay. The expression levels of the enterotoxin genes hblA, hblD, nheA, nheB and nheC, determined by means of RT real-time PCR in B. toyonensis, were lower than those in B. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214536PLOS

Applying hydrodynamic pressure to efficiently generate induced pluripotent stem cells via reprogramming of centenarian skin fibroblasts.

PLoS One 2019 25;14(4):e0215490. Epub 2019 Apr 25.

Division of Pathology, Department of Laboratory Medicine, Karolinska Institute, Stockholm, Sweden.

Induced pluripotent stem cell (iPSC)-technology is an important platform in medicine and disease modeling. Physiological degeneration and disease onset are common occurrences in the aging population. iPSCs could offer regenerative medical options for age-related degeneration and disease in the elderly. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215490PLOS

The evolution of a super-swarm of foot-and-mouth disease virus in cattle.

PLoS One 2019 25;14(4):e0210847. Epub 2019 Apr 25.

Foreign Animal Disease Research Unit, Plum Island Animal Disease Center, ARS, USDA, Greenport, NY, United States of America.

Foot-and-mouth disease (FMD) is a highly contagious viral disease that severely impacts global food security and is one of the greatest constraints on international trade of animal products. Extensive viral population diversity and rapid, continuous mutation of circulating FMD viruses (FMDVs) pose significant obstacles to the control and ultimate eradication of this important transboundary pathogen. The current study investigated mechanisms contributing to within-host evolution of FMDV in a natural host species (cattle). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210847PLOS

Leveraging heterogeneity for neural computation with fading memory in layer 2/3 cortical microcircuits.

PLoS Comput Biol 2019 Apr 25;15(4):e1006781. Epub 2019 Apr 25.

Institute of Neuroscience and Medicine (INM-6), Institute for Advanced Simulation (IAS-6) and JARA Institute Brain Structure-Function Relationships (JBI-1 / INM-10), Jülich Research Centre, Jülich, Germany.

Complexity and heterogeneity are intrinsic to neurobiological systems, manifest in every process, at every scale, and are inextricably linked to the systems' emergent collective behaviours and function. However, the majority of studies addressing the dynamics and computational properties of biologically inspired cortical microcircuits tend to assume (often for the sake of analytical tractability) a great degree of homogeneity in both neuronal and synaptic/connectivity parameters. While simplification and reductionism are necessary to understand the brain's functional principles, disregarding the existence of the multiple heterogeneities in the cortical composition, which may be at the core of its computational proficiency, will inevitably fail to account for important phenomena and limit the scope and generalizability of cortical models. Read More

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http://dx.doi.org/10.1371/journal.pcbi.1006781DOI Listing

Structure of the human ClC-1 chloride channel.

PLoS Biol 2019 Apr 25;17(4):e3000218. Epub 2019 Apr 25.

Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.

ClC-1 protein channels facilitate rapid passage of chloride ions across cellular membranes, thereby orchestrating skeletal muscle excitability. Malfunction of ClC-1 is associated with myotonia congenita, a disease impairing muscle relaxation. Here, we present the cryo-electron microscopy (cryo-EM) structure of human ClC-1, uncovering an architecture reminiscent of that of bovine ClC-K and CLC transporters. Read More

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http://dx.doi.org/10.1371/journal.pbio.3000218DOI Listing

Hydrodynamics of transient cell-cell contact: The role of membrane permeability and active protrusion length.

PLoS Comput Biol 2019 Apr 25;15(4):e1006352. Epub 2019 Apr 25.

Department of Mathematics, University of California Irvine, Irvine, California, United States of America.

In many biological settings, two or more cells come into physical contact to form a cell-cell interface. In some cases, the cell-cell contact must be transient, forming on timescales of seconds. One example is offered by the T cell, an immune cell which must attach to the surface of other cells in order to decipher information about disease. Read More

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http://dx.doi.org/10.1371/journal.pcbi.1006352DOI Listing

Is microcirculatory assessment ready for regular use in clinical practice?

Authors:
Daniel De Backer

Curr Opin Crit Care 2019 Jun;25(3):280-284

Department of Intensive Care, CHIREC Hospitals, Université Libre de Bruxelles, Brussels, Belgium.

Purpose Of Review: The present review discusses the current role of microcirculatory assessment in the hemodynamic monitoring of critically ill patients.

Recent Findings: Videomicroscopic techniques have demonstrated that microvascular perfusion is altered in critically ill patients, and especially in sepsis. These alterations are associated with organ dysfunction and poor outcome. Read More

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http://dx.doi.org/10.1097/MCC.0000000000000605DOI Listing

Effectiveness of avatar-based technology in patient education for improving chronic disease knowledge and self-care behavior: a systematic review.

JBI Database System Rev Implement Rep 2019 Apr 23. Epub 2019 Apr 23.

College of Nursing and Health Sciences, Flinders University, Adelaide, Australia.

Objective: The objective of the review was to examine the effectiveness of patient education using avatar-based technology on knowledge and self-care behaviors in patients with chronic disease.

Introduction: Chronic disease is a major global problem. Patients with chronic disease who engage in self-care and self-management of their illnesses have better health outcomes and fewer hospitalizations and complications. Read More

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http://dx.doi.org/10.11124/JBISRIR-2017-003905DOI Listing

The Impact of a Stress Management Program on the Stress Response of Nurses in Neonatal Intensive Care Units: A Quasi-Experimental Study.

J Perinat Neonatal Nurs 2019 Apr/Jun;33(2):189-195

Nursing Care Research Center (Dr Borimnejad), School of Nursing and Midwifery (Ms Lary and Dr Mardani-Hamooleh), Iran University of Medical Sciences, Tehran, Iran.

This study was conducted with the aim to determine the effect of a stress management program on the response to stress by nurses working in neonatal intensive care units. This quasi-experimental study was conducted on 70 nurses in Iran. The nurses were assigned to the 2 groups: experimental and control groups, with each group comprising 35 participants. Read More

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http://dx.doi.org/10.1097/JPN.0000000000000396DOI Listing

The Effect of Intraoperative Vertebral Anesthesia on Osteoporotic Fractures Treated With Percutaneous Kyphoplasty: A Prospective Cohort Study.

Clin Spine Surg 2019 Apr 23. Epub 2019 Apr 23.

Department of Orthopedics, State Key Clinical Department of China.

Study Design: A prospective randomized cohort study.

Objective: The objective of this study was to investigate the effect of intraoperative vertebral anesthesia on osteoporotic vertebral compression fractures (OVCFs) when treated with percutaneous kyphoplasty (PKP).

Summary Of Background Data: Only a few studies have evaluated the intraoperative pain reducing strategies during PKP. Read More

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http://dx.doi.org/10.1097/BSD.0000000000000823DOI Listing

Nonlocal Low-Rank Tensor Completion for Visual Data.

IEEE Trans Cybern 2019 Apr 24. Epub 2019 Apr 24.

In this paper, we propose a novel nonlocal patch tensor-based visual data completion algorithm and analyze its potential problems. Our algorithm consists of two steps: the first step is initializing the image with triangulation-based linear interpolation and the second step is grouping similar nonlocal patches as a tensor then applying the proposed tensor completion technique. Specifically, with treating a group of patch matrices as a tensor, we impose the low-rank constraint on the tensor through the recently proposed tensor nuclear norm. Read More

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http://dx.doi.org/10.1109/TCYB.2019.2910151DOI Listing

A Mixture-of-Experts Prediction Framework for Evolutionary Dynamic Multiobjective Optimization.

IEEE Trans Cybern 2019 Apr 24. Epub 2019 Apr 24.

Dynamic multiobjective optimization requires the robust tracking of varying Pareto-optimal solutions (POS) in a changing environment. When a change is detected in the environment, prediction mechanisms estimate the POS by utilizing information from previous populations to accelerate search toward the true POS. To achieve a robust prediction of POS, a mixture-of-experts-based ensemble framework is proposed. Read More

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http://dx.doi.org/10.1109/TCYB.2019.2909806DOI Listing

Deep Attentive Features for Prostate Segmentation in 3D Transrectal Ultrasound.

IEEE Trans Med Imaging 2019 Apr 25. Epub 2019 Apr 25.

Automatic prostate segmentation in transrectal ultrasound (TRUS) images is of essential importance for image-guided prostate interventions and treatment planning. However, developing such automatic solutions remains very challenging due to the missing/ambiguous boundary and inhomogeneous intensity distribution of the prostate in TRUS, as well as the large variability in prostate shapes. This paper develops a novel 3D deep neural network equipped with attention modules for better prostate segmentation in TRUS by fully exploiting the complementary information encoded in different layers of the convolutional neural network (CNN). Read More

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http://dx.doi.org/10.1109/TMI.2019.2913184DOI Listing

Latent Representation Learning for Alzheimer's Disease Diagnosis with Incomplete Multi-modality Neuroimaging and Genetic Data - Supplementary Materials.

IEEE Trans Med Imaging 2019 Apr 25. Epub 2019 Apr 25.

The fusion of complementary information contained in multi-modality data (e.g., Magnetic Resonance Imaging (MRI), Positron Emission Tomography (PET) and genetic data) has advanced the progress of automated Alzheimer's disease (AD) diagnosis. Read More

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http://dx.doi.org/10.1109/TMI.2019.2913158DOI Listing
April 2019
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Person Reidentification via Unsupervised Cross-View Metric Learning.

IEEE Trans Cybern 2019 Apr 22. Epub 2019 Apr 22.

Person reidentification (Re-ID) aims to match observations of individuals across multiple nonoverlapping camera views. Recently, metric learning-based methods have played important roles in addressing this task. However, metrics are mostly learned in supervised manners, of which the performance relies heavily on the quantity and quality of manual annotations. Read More

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http://dx.doi.org/10.1109/TCYB.2019.2909480DOI Listing

Granular Fuzzy Modeling Guided Through the Synergy of Granulating Output Space and Clustering Input Subspaces.

IEEE Trans Cybern 2019 Apr 19. Epub 2019 Apr 19.

As an augmentation of classic fuzzy models, granular fuzzy models (GFMs) have been applied to many fields being in rapport with experimental data, models, and users. However, most of the existing methods used to construct GFMs are based on the principle of optimal allocation of information granularity, which requires that a numeric model be provided in advance. In this paper, a straightforward and convincing modeling method is proposed to directly construct GFM on a basis of experimental data. Read More

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http://dx.doi.org/10.1109/TCYB.2019.2909037DOI Listing

Stacking-Based Deep Neural Network: Deep Analytic Network for Pattern Classification.

IEEE Trans Cybern 2019 Apr 22. Epub 2019 Apr 22.

Stacking-based deep neural network (S-DNN) is aggregated with pluralities of basic learning modules, one after another, to synthesize a deep neural network (DNN) alternative for pattern classification. Contrary to the DNNs trained from end to end by backpropagation (BP), each S-DNN layer, that is, a self-learnable module, is to be trained decisively and independently without BP intervention. In this paper, a ridge regression-based S-DNN, dubbed deep analytic network (DAN), along with its kernelization (K-DAN), are devised for multilayer feature relearning from the pre-extracted baseline features and the structured features. Read More

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http://dx.doi.org/10.1109/TCYB.2019.2908387DOI Listing

Differential Evolution for Multimodal Optimization With Species by Nearest-Better Clustering.

IEEE Trans Cybern 2019 Apr 22. Epub 2019 Apr 22.

Multimodal optimization problems (MMOPs) are common in real-world applications and involve identifying multiple optimal solutions for decision makers to choose from. The core requirement for dealing with such problems is to balance the ability of exploration in the global space and exploitation in the multiple optimal areas. In this paper, based on the differential evolution (DE), we propose a novel algorithm focusing on the formulation, balance, and keypoint of species for MMOPs, called FBK-DE. Read More

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http://dx.doi.org/10.1109/TCYB.2019.2907657DOI Listing

Segmenting diabetic retinopathy lesions in multispectral images using low-dimensional spatial-spectral matrix representation.

IEEE J Biomed Health Inform 2019 Apr 22. Epub 2019 Apr 22.

Multispectral Imaging (MSI) provides a sequence of en-face fundus spectral slices and allows for the examination of structures and signatures throughout the thickness of retina to characterize diabetic retinopathy (DR) lesions comprehensively. Manual interpretation of MSI images is commonly conducted by qualitatively analyzing both the spatial and spectral properties of multiple spectral slices. Meanwhile, there exist few computer-based algorithms that can effectively exploit the spatial and spectral information of MSI images for the diagnosis of DR. Read More

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http://dx.doi.org/10.1109/JBHI.2019.2912668DOI Listing

Deep Residual Inception Encoder-Decoder Network for Medical Imaging Synthesis.

IEEE J Biomed Health Inform 2019 Apr 22. Epub 2019 Apr 22.

Image synthesis is a novel solution in precision medicine for scenarios where important medical imaging is not otherwise available. Convolutional neural network is an ideal model for this task because of its powerful learning capabilities through the large number of layers and trainable parameters. In this research, we propose a new architecture of Residual Inception Encoder-Decoder Neural Network (RIED-Net) to learn the nonlinear mapping between the input images and targeting output images. Read More

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http://dx.doi.org/10.1109/JBHI.2019.2912659DOI Listing

Joint and Direct Optimization for Dictionary Learning in Convolutional Sparse Representation.

Authors:
Guan-Ju Peng

IEEE Trans Neural Netw Learn Syst 2019 Apr 19. Epub 2019 Apr 19.

Convolutional sparse coding (CSC) is a useful tool in many image and audio applications. Maximizing the performance of CSC requires that the dictionary used to store the features of signals can be learned from real data. The so-called convolutional dictionary learning (CDL) problem is formulated within a nonconvex, nonsmooth optimization framework. Read More

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http://dx.doi.org/10.1109/TNNLS.2019.2906074DOI Listing

Enhanced Diagnosis of Pneumothorax with an Improved Real-time Augmentation for Imbalanced Chest X-rays Data Based on DCNN.

IEEE/ACM Trans Comput Biol Bioinform 2019 Apr 19. Epub 2019 Apr 19.

Pneumothorax is a common pulmonary disease that can lead to dyspnea and can be life-threatening. X-ray examination is the main means to diagnose this disease. Computer-aided diagnosis of pneumothorax on chest X-ray, as a prerequisite for timely cure, has been widely studied, but it is still not satisfactory to achieve highly accurate results. Read More

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http://dx.doi.org/10.1109/TCBB.2019.2911947DOI Listing

Adversarial Learning Semantic Volume for 2D/3D Face Shape Regression in the Wild.

IEEE Trans Image Process 2019 Apr 19. Epub 2019 Apr 19.

Regression based methods have revolutionized 2D landmark localization with the exploitation of deep neural networks and massive annotated datasets in the wild. However, it remains challenging for 3D landmark localization due to the lack of annotated datasets and the ambiguous nature of landmarks under 3D perspective. This paper revisits regression based methods and proposes an adversarial voxel and coordinate regression framework for 2D and 3D facial landmark localization in real-world scenarios. Read More

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http://dx.doi.org/10.1109/TIP.2019.2911114DOI Listing
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