1,414,888 results match your criteria Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation[Journal]


Infection of HeLa cells with Chlamydia trachomatis inhibits protein synthesis and causes multiple changes to host cell pathways.

Cell Microbiol 2018 Dec 14:e12993. Epub 2018 Dec 14.

Institute for Microbiology and Hygiene, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.

The obligate intracellular bacterium Chlamydia trachomatis replicates in a cytosolic vacuole in human epithelial cells. Infection of human cells with C. trachomatis causes substantial changes to many host cell signalling pathways but the molecular basis of such influence is not well understood. Read More

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December 2018

Centrifugation affects the purity of liquid biopsy-based tumor biomarkers.

Cytometry A 2018 Dec;93(12):1207-1212

Amsterdam UMC, University of Amsterdam, Laboratory of Experimental Clinical Chemistry, Amsterdam, the Netherlands.

Biomarkers in the blood of cancer patients include circulating tumor cells (CTCs), tumor-educated platelets (TEPs), tumor-derived extracellular vesicles (tdEVs), EV-associated miRNA (EV-miRNA), and circulating cell-free DNA (ccfDNA). Because the size and density of biomarkers differ, blood is centrifuged to isolate or concentrate the biomarker of interest. Here, we applied a model to estimate the effect of centrifugation on the purity of a biomarker according to published protocols. Read More

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December 2018

Work Loss Before and After Diagnosis of Crohn's Disease.

Inflamm Bowel Dis 2018 Dec 14. Epub 2018 Dec 14.

Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.

Background: The aim of this study was to examine work loss in patients with Crohn's disease.

Methods: Using nationwide registers, we identified incident patients with Crohn's disease (2007-2010) and population comparator subjects without inflammatory bowel disease, matched by age, sex, calendar year, health care region, and education level. We assessed the number of lost workdays due to sick leave and disability pension from 5 years before to 5 years after first diagnosis of Crohn's disease or end of follow-up (September 30, 2015). Read More

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December 2018
1 Read

Cytological and molecular aspects of the ageing sperm.

Hum Reprod 2018 Dec 14. Epub 2018 Dec 14.

Laboratory of Seminology - Sperm Bank 'Loredana Gandini' Department of Experimental Medicine, 'Sapienza' University of Rome, Italy.

Study Question: Is ageing associated with a decline in semen quality and molecular changes to human sperm?

Summary Answer: Semen quality declines with advancing age and characteristic molecular changes take place during the ageing process, including increased sperm DNA damage, altered sperm protamination and altered seminal plasma miRNA profile.

What Is Known Already: During ageing, the reproductive system is exposed to physiological changes and potentially damaging factors that may impair testicular function. Reactive oxygen species (ROS) can induce errors during DNA replication, transcription or post-transcriptional events (fragmentation, chromatin condensation abnormalities and protamine expression defects). Read More

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December 2018

Promoting access equity and improving health care for women, children and people living with HIV/AIDS in Burkina Faso through mHealth.

J Public Health (Oxf) 2018 Dec;40(suppl_2):ii42-ii51

Université de Montréal, CHU Sainte-Justine, Canada.

Background: In Burkina Faso, access to health services for women, children and people living with HIV/AIDS (PLWHAs) remains limited. Mobile telephony offers an alternative solution for reaching these individuals. The objective of the study was to improve equity of access to health care and information among women and PLWHAs by reinforcing community participation. Read More

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December 2018

Significant inhibition of photosynthesis and respiration in leaves of Cucumis sativus L. by oxybenzone, an active ingredient in sunscreen.

Chemosphere 2018 Dec 3;219:456-462. Epub 2018 Dec 3.

State Key Laboratory of Crop Biology, China; College of Life Sciences, Shandong Agricultural University, China. Electronic address:

Oxybenzone (OBZ), an active ingredient in most sunscreens, was recently shown to be toxic to humans, corals and other animals. This study is the first to demonstrate that OBZ can significantly inhibit photosynthesis and respiration in the leaves of a higher plant, cucumber. An OBZ suspension content as low as 0. Read More

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December 2018
1 Read

Origin of neck pain and direction of movement influence dynamic cervical joint motion and pressure pain sensitivity.

Clin Biomech (Bristol, Avon) 2018 Dec 5;61:120-128. Epub 2018 Dec 5.

Center for Neuroplasticity and Pain (CNAP), SMI, Department of Health and Science Technology, Faculty of Medicine, Aalborg University, Denmark.

Background: Patients with neck pain normally showed alterations in cervical motion and pressure pain sensitivity. Cervical joints show scattered motions opposite to (anti-directional) the primary motion direction (pro-directional) during dynamic cervical flexion and extension. This study aimed to assess dynamic cervical joint motion and pressure pain sensitivity when pain originated from different cervical muscles which may have clinical relevance in diagnosis of impairments related with neck pain. Read More

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December 2018

Common genetic variants contribute to incomplete penetrance: evidence from cancer-free BRCA1 mutation carriers.

Eur J Cancer 2018 Dec 11;107:68-78. Epub 2018 Dec 11.

Department of Genetics, Cell Biology and Anatomy, College of Medicine, USA; Cancer Centre and Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Taipa, Macau, SAR, China. Electronic address:

Purpose: The presence of pathogenic germline mutation in BRCA1 gene is considered as the most penetrant genetic predisposition for breast cancer. However, a portion of BRCA1 mutation carriers never develops breast cancer throughout their lifetime. This phenomenon is called incomplete penetrance. Read More

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December 2018

A prediction method of speed-dependent walking patterns for healthy individuals.

Gait Posture 2018 Dec 5;68:280-284. Epub 2018 Dec 5.

Federal University of ABC, Neuroscience and Biomedical Engineering Programs, São Bernardo do Campo, São Paulo, Brazil. Electronic address:

Background: Gait speed is one of the main biomechanical determinants of human movement patterns. However, in clinical gait analysis, the effect of gait speed is generally not considered, and people with disabilities are usually compared with able-bodied individuals even though disabled people tend to walk slower.

Research Questions: This study proposes a simple way to predict the gait pattern of healthy individuals at a specific speed. Read More

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December 2018

Signal enhanced proteomics: a biological perspective on dissecting the functional organisation of cell proteomes.

Curr Opin Chem Biol 2018 Dec 11;48:114-122. Epub 2018 Dec 11.

Laboratory of Quantitative Proteomics, Centre for Gene Regulation and Expression, School of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK. Electronic address:

Proteomes are highly dynamic and can respond rapidly to environmental and cellular signals. Within cells, proteins often form distinct pools with different functions and properties. However, in quantitative proteomics studies it is common to measure averaged values for proteins that do not reflect variations that may occur between different protein isoforms, different subcellular compartments, or in cells at different cell cycle stages and so on. Read More

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December 2018

Synaptic potentiation and rapid antidepressant response to ketamine in treatment-resistant major depression: A replication study.

Psychiatry Res Neuroimaging 2018 Sep 12;283:64-66. Epub 2018 Sep 12.

Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA.

Preclinical and clinical evidence has demonstrated that ketamine has rapid antidepressant effects. Studies using pre-treatment with an AMPA inhibitor suggest that enhancing AMPA throughput is crucial to ketamine's effects, including increases in both basal and evoked gamma power. This study sought to replicate previous findings of increased gamma response to a somatosensory stimulus at 230 min and Day 1 in ketamine responders versus non-responders in 31 depressed subjects and 25 healthy controls. Read More

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September 2018

Neutral/negative α-AR antagonists and calcium channel blockers at comparison in functional tests on guinea-pig smooth muscle and myocardium.

Pharmacol Rep 2018 Oct 11;71(1):128-132. Epub 2018 Oct 11.

Dipartimento di Farmacia e Biotecnologie, Università degli Studi di Bologna, Bologna, Italy. Electronic address:

Background: Constitutive (agonist-independent) activity is a prerogative of many G protein-coupled receptors (GPCRs) including α-adrenoceptors (α-ARs). Inhibition of such an activity at α-AR subtypes by antagonists with negative efficacy is difficult to be adequately tested.

Methods: In the present experimental approach, we compared the activity of three calcium channel blockers (nifedipine, diltiazem and verapamil) and of three potent benzodioxane-based α-AR antagonists, differing for subtype selectivity and inverse agonist properties, in producing smooth muscle relaxation and negative inotropy under the same test conditions. Read More

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October 2018

A randomized controlled trial to test efficacy of digital enhancements of storybooks in support of narrative comprehension and word learning.

J Exp Child Psychol 2018 Dec 11;179:212-226. Epub 2018 Dec 11.

Institute of Education, ELTE Eötvös Loránd University, 1053 Budapest, Hungary; Department of Language, Literature and Communication, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, the Netherlands; Faculty of Arts and Education, University of Stavanger, 4036 Stavanger, Norway.

Experiments with film-like story presentations have been found to be beneficial in supporting children's story comprehension and word learning. The main goal of the current study was to disentangle the effects of visual and auditory enhancements in digital books. Participants were 99 typically developing children (41 boys and 58 girls) aged 4-6 years from two public kindergartens in Bursa, Turkey. Read More

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December 2018

Characterization of locomotor response to psychostimulants in the parthenogenetic marbled crayfish (Procambarus fallax forma virginalis): A promising model for studying the neural and molecular mechanisms of drug addiction.

Behav Brain Res 2018 Dec 11. Epub 2018 Dec 11.

J.P. Scott Center for Neuroscience, Mind & Behavior, and Department of Biological Sciences, Bowling Green State University, Bowling Green, OH 43403, USA.

Although scientific research using mammalian models has made great strides in uncovering the enigmatic neural and molecular mechanisms orchestrating the state of drug addiction, a complete understanding has thus far eluded researchers. The complexity of the task has led to the use of invertebrate model systems to complement the research of drug-induced reward in mammalian systems. Invertebrates, such as crayfish, offer excellent model systems to help reveal the underlying mechanisms of drug addiction as they retain the ancestral neural reward circuit that is evolutionarily conserved across taxa, and they possess relatively few, large neurons, laid out in an accessible, modularly organized nervous system. Read More

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December 2018

Distinct regulation pattern of Egr-1, BDNF and Arc during morphine-withdrawal conditioned place aversion paradigm: role of glucocorticoids.

Behav Brain Res 2018 Dec 11. Epub 2018 Dec 11.

Department of Pharmacology, University of Murcia, Murcia, Spain; Murcia Institute of Biomedical Research (IMIB), University of Murcia, Spain.

Negative affective aspects of opiate abstinence contribute to the persistence of substance abuse. Importantly, interconnected brain areas involved in aversive motivational processes, such as the ventral tegmental area (VTA) and medial prefrontal cortex (mPFC), become activated when animals are confined to withdrawal-paired environments. In the present study, place aversion was elicited in sham and adrenalectomized (ADX) animals by conditioned naloxone-precipitated drug withdrawal following exposure to chronic morphine. Read More

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December 2018

Effect of education using the virtual social network on the knowledge and attitude of emergency nurses of disaster preparedness: A quasi-experiment study.

Nurse Educ Today 2018 Dec 6;73:88-93. Epub 2018 Dec 6.

School of Nursing and Midwifery, Iran University of Medical Sciences, Tehran, Iran. Electronic address:

Background: Nurses play an important role in helping people to cope with disasters. Dealing with disasters requires proper knowledge, attitudes and skills that can be achieved through education. Education through virtual social networks as a method of distance education can be used due to its accessibility and ease of use. Read More

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December 2018

Levels of circulating soluble LR11, a regulator of smooth muscle cell migration, are highly associated with atherosclerotic plaques in patients with carotid artery stenosis.

Clin Chim Acta 2018 Dec 11. Epub 2018 Dec 11.

Department of Clinical-Laboratory and Experimental-Research Medicine, Toho University Sakura Medical Center, 564-1 Shimoshizu, Sakura 285-8741, Japan. Electronic address:

Background: The levels of plasma sLR11, released from intimal SMCs, are positively associated with intima-media thickness (IMT) in asymptomatic subjects. We have evaluated the yet unknown pathological significance of sLR11 for plaque conditions in patients with carotid artery stenosis.

Methods: The presence of LR11 in carotid plaques was investigated using autopsy specimens. Read More

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December 2018

Combining land preparation and vegetation restoration for optimal soil eco-hydrological services in the Loess Plateau, China.

Sci Total Environ 2018 Dec 3;657:535-547. Epub 2018 Dec 3.

State Key Laboratory of Urban and Regional Ecology, Research Center for Eco-environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; Department of Sediment Research, China Institute of Water Resource and Hydropower Research, Beijing 100048.

In semiarid terrestrial ecosystems, optimized eco-rehabilitation strategies, such as land preparations and planting vegetation, are keys to achieve a successful ecological restoration. Land preparations and vegetation are supposed to have the coupled and respective impacts on soil ecosystem services, which are still unclear now. In this study, eighteen experimental plots with six different combinations and repetitions of land preparations and vegetation were built in the Chinese Loess Plateau in 2014 and soil moisture storages (SMS), soil carbon stocks (SCS) and other soil nutrient stocks were calculated at 0-100 cm, also the effects of land preparations and planting vegetation on soil eco-hydrological services are analyzed by mathematical methods. Read More

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December 2018

The effects of filters for an intelligent air pollutant control system considering natural ventilation and the occupants.

Sci Total Environ 2018 Dec 5;657:410-419. Epub 2018 Dec 5.

Department of Architecture and Architectural Engineering, Yonsei University, Seoul 03722, Republic of Korea.

Experimental analysis was conducted on the indoor air pollutant concentration using natural ventilation and filters. The study targeted two office rooms each of which was occupied by four people, and with the same outdoor environments. A non-woven fabric filter (room A) and an electrostatic filter (room B) were installed on the window frame, and the indoor air pollutant concentration and indoor climate factors were monitored based on the number of occupants and the occupants' activities. Read More

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December 2018

Fog collection as a strategy to sequester carbon in drylands.

Sci Total Environ 2018 Dec 5;657:391-400. Epub 2018 Dec 5.

Department of Agricultural, Food and Forestry Systems (GESAAF), Università degli Studi di Firenze, Florence, Italy. Electronic address:

Advection fog is the sole source of water for many near-the-sea arid areas worldwide such as the lomas, i.e. fog-dependant landscapes of the coastal zone of Peru and Northern Chile, where deforestation occurred since 16th century, leading to a progressive and severe desertification. Read More

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December 2018

Cellular landmarks of Trypanosoma brucei and Leishmania mexicana.

Mol Biochem Parasitol 2018 Dec 11. Epub 2018 Dec 11.

The Peter Medawar Building for Pathogen Research, University of Oxford, South Parks Road, Oxford, OX1 3SY, UK. Electronic address:

The kinetoplastids Trypanosoma brucei and Leishmania mexicana are eukaryotes with a highly structured cellular organisation that is reproduced with great fidelity in each generation. The pattern of signal from a fluorescently tagged protein can define the specific structure/organelle that this protein localises to, and can be extremely informative in phenotype analysis in experimental perturbations, life cycle tracking, post-genomic assays and functional analysis of organelles. Using the vast coverage of protein subcellular localisations provided by the TrypTag project, an ongoing project to determine the localisation of every protein encoded in the T. Read More

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December 2018

Traditional attributes moo-ve over for some consumer segments: Relative ranking of fluid milk attributes.

Appetite 2018 Dec 11. Epub 2018 Dec 11.

Dept. of Agricultural Economics, Purdue University, 403 West State Street, West Lafayette, IN, 47907, USA.

Due to the decrease in fluid milk consumption as a beverage in the United States, the importance for dairy industry stakeholders to understand attribute preferences for consumer segments has increased. This paper uses a representative sample of U.S. Read More

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December 2018

Emergent neural turing machine and its visual navigation.

Neural Netw 2018 Nov 27;110:116-130. Epub 2018 Nov 27.

Department of Computer Science and Engineering, Michigan State University, East Lansing, MI, 48824, USA; Cognitive Science Program, Michigan State University, East Lansing, MI, 48824, USA; Neuroscience Program, Michigan State University, East Lansing, MI, 48824, USA.

Traditional Turing Machines (TMs) are symbolic whose hand-crafted representations are static and limited. Developmental Network 1 (DN-1) uses emergent representation to perform Turing Computation. But DN-1 lacks hierarchy in its internal representations, and is hard to handle the complex visual navigation tasks. Read More

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November 2018

Reducing the Complexity of Mathematical Models for the Plant Circadian Clock by Distributed Delays.

J Theor Biol 2018 Dec 11. Epub 2018 Dec 11.

Sainsbury Laboratory, University of Cambridge, Bateman Street, Cambridge, CB2 1LR, UK. Electronic address:

A major bottleneck in the modelling of biological networks is the parameter explosion problem - the exponential increase in the number of parameters that need to be optimised to data as the size of the model increases. Here, we address this problem in the context of the plant circadian clock by applying the method of distributed delays. We show that using this approach, the system architecture can be simplified efficiently - reducing the number of parameters - whilst still preserving the core mechanistic dynamics of the gene regulatory network. Read More

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December 2018

Osteocytes reflect a pro-inflammatory state following spinal cord injury in a rodent model.

Bone 2018 Dec 11. Epub 2018 Dec 11.

Department of Neuroscience and Experimental Therapeutics, Texas A&M Health Science Center, Bryan, TX, United States of America.

Profound bone loss occurs following spinal cord injury (SCI) resulting in a high incidence of fractures. While likely caused in part by loss of weight-bearing, there is greater bone loss following SCI when compared to that observed in other disuse animal models. Patients with SCI have a protracted inflammatory response, with elevated circulating levels of pro-inflammatory markers. Read More

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December 2018

Somatosensory Evoked Potential Changes and Decompression Timing for Spinal Cord Function Recovery and Evoked Potentials in Rats with Spinal Cord Injury.

Brain Res Bull 2018 Dec 11. Epub 2018 Dec 11.

Department of Anesthesiology, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei, 442000, China. Electronic address:

Objective: The study aimed to evaluate changes of somatosensory evoked potentials and the effects of decompression timing on spinal cord recovery and evoked potentials by measuring the somatosensory evoked potentials of rats with spinal cord injury at different time points.

Methods: A total of 70 SD rats were divided into the control group (group A) and the experimental group. The experimental groups included group B, C and D according to the severity of spinal cord injury. Read More

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December 2018

Degradation Rate Observations as a Function of Drug Load in Solid State Drug Products.

J Pharm Sci 2018 Dec 11. Epub 2018 Dec 11.

Analytical Research & Development, Pfizer Inc, Sandwich, UK.

Degradation rates of solid state drug products generally increase as the drug load decreases. A model for quantifying this effect based on surface area ratios is proposed here. This model relates the degradation rate to an estimate of the proportion of drug substance in contact with the excipient, and that the drug substance in contact with excipients degrades more quickly. Read More

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December 2018

Predicting drug-target interactions using Lasso with random forest based on evolutionary information and chemical structure.

Genomics 2018 Dec 11. Epub 2018 Dec 11.

College of Mathematics and Physics, Qingdao University of Science and Technology, Qingdao 266061, China; Artificial Intelligence and Biomedical Big Data Research Center, Qingdao University of Science and Technology, Qingdao 266061, China; School of Life Sciences, University of Science and Technology of China, Hefei 230027, China. Electronic address:

The identification of drug-target interactions has great significance for pharmaceutical scientific research. Since traditional experimental methods identifying drug-target interactions is costly and time-consuming, the use of machine learning methods to predict potential drug-target interactions has attracted widespread attention. This paper presents a novel drug-target interactions prediction method called LRF-DTIs. Read More

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December 2018

Resveratrol prevents cognitive deficits by attenuating oxidative damage and inflammation in rat model of streptozotocin diabetes induced vascular dementia.

Physiol Behav 2018 Dec 11. Epub 2018 Dec 11.

Kocaeli University Faculty of Medicine, Department of Pharmacology, Kocaeli, Turkey; Kocaeli University, Experimental Medical Research and Application Centre, Kocaeli, Turkey.

Diabetes is one of the risk factors for the development of vascular dementia (VD), leading to endothelial dysfunction and cognitive impairment. Resveratrol has been shown to have antioxidant, antiinflammatory, and neuroprotective effects. The previous studies have also reported that resveratrol improves cognitive and vascular endothelial functions in several pathological conditions. Read More

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December 2018

Combined Raman- and AFM-based detection of biochemical and nanomechanical features of endothelial dysfunction in aorta isolated from ApoE/LDLR-/- mice.

Nanomedicine 2018 Dec 11. Epub 2018 Dec 11.

Institute of Physiology II, University of Münster, Münster, Germany; Institute of Physiology, University of Lübeck, Lübeck, Germany. Electronic address:

Endothelial dysfunction is recognized as a critical condition in the development of cardiovascular disorders. This multifactorial process involves changes in the biochemical and mechanical properties of endothelial cells leading to disturbed release of vasoprotective mediators. Hypercholesterolemia and increased stiffness of the endothelial cortex are independently shown to result in reduced release of nitric oxide and thus endothelial dysfunction. Read More

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December 2018

Assessment of GFP Tag Position on Protein Localization and Growth Fitness in Yeast.

J Mol Biol 2018 Dec 12. Epub 2018 Dec 12.

Department of Plant and Environmental Sciences, Weizmann Institute of Science, Rehovot 7610001, Israel. Electronic address:

While protein tags are ubiquitously utilized in molecular biology, they harbor the potential to interfere with functional traits of their fusion counterparts. Systematic evaluation of the effect of protein tags on function would promote accurate use of tags in experimental setups. Here we examine the effect of Green Fluorescent Protein (GFP) tagging at either the N or C terminus of budding yeast proteins on subcellular localization and functionality. Read More

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December 2018

Impact of material properties and process variables on the residence time distribution in twin screw feeding equipment.

Int J Pharm 2018 Dec 11. Epub 2018 Dec 11.

Laboratory of Pharmaceutical Technology, Department of Pharmaceutics, Ghent University, Ottergemsesteenweg 460, B-9000 Ghent, Belgium.

Screw feeders are integrated as dispensing units in most continuous manufacturing platforms. Hence, characterizing and modelling the residence time distribution (RTD) of materials in feeders is indispensable to understand the traceability of raw materials from the drum till tablet, enabling the separation of non-confirming material. The proposed methodology addressed this leap in knowledge by characterizing materials, performing RTD trials according to an experimental design, applying RTD models and establishing a partial least square (PLS) regression model that links the material properties and process variables with the RTD responses as outputs. Read More

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December 2018

3D simulation of solutes concentration in urinary concentration mechanism in rat renal medulla.

Math Biosci 2018 Dec 11. Epub 2018 Dec 11.

Division of General Internal Medicine, Department of Medicine, Toronto General Hospital, Toronto.

In this work, a mathematical model was developed to simulate the urinary concentration mechanism. A 3-D geometry was derived based on the detail physiological pictures of rat kidney. The approximate region of each tubule was obtained from the volume distribution of structures based on Walter Pfaller's monograph and Layton's region-based model. Read More

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December 2018

The cytochrome b lysine 329 residue is critical for ubihydroquinone oxidation and proton release at the Q site of bacterial cytochrome bc.

Biochim Biophys Acta Bioenerg 2018 Dec 11. Epub 2018 Dec 11.

Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

The ubihydroquinone:cytochrome (cyt) c oxidoreductase (or cyt bc) is an important enzyme for photosynthesis and respiration. In bacteria like Rhodobacter capsulatus, this membrane complex has three subunits, the iron‑sulfur protein (ISP) with its FeS cluster, cyt c and cyt b, forming two catalytic domains, the Q (hydroquinone (QH) oxidation) and Q (quinone (Q) reduction) sites. At the Q site, the electron transfer pathways originating from QH oxidation are known, but their associated proton release routes are less well defined. Read More

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December 2018

What Regulates Gratitude Response of Women and Men? The Role of the Received Good, Psychosocial Factors, and Repayment.

Psychol Rep 2018 Dec 14:33294118811620. Epub 2018 Dec 14.

Department of Psychiatry, Pomeranian Medical University in Szczecin, Poland.

This paper touches upon gender differences concerning psychosocial factors related to the emotional reaction of gratitude and forms of expressing gratitude in quasi-experimental conditions. It is based on findings from a study conducted on 576 participants of both sexes, aged 14 to 86 years. There were used three versions of the same questionnaire, depending on the type of the received good-material, intangible, or none. Read More

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December 2018

The Role of Common Factors in Psychotherapy Outcomes.

Annu Rev Clin Psychol 2018 Dec 14. Epub 2018 Dec 14.

Department of Clinical, Neuro-, and Developmental Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, 1081 BT Amsterdam, The Netherlands; email:

Psychotherapies may work through techniques that are specific to each therapy or through factors that all therapies have in common. Proponents of the common factors model often point to meta-analyses of comparative outcome studies that show all therapies have comparable effects. However, not all meta-analyses support the common factors model; the included studies often have several methodological problems; and there are alternative explanations for finding comparable outcomes. Read More

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December 2018

Evaluating the Efficiency of Primer Extension Capture as a Method to Enrich DNA Extractions.

J Forensic Sci 2018 Dec 14. Epub 2018 Dec 14.

Laboratories of Molecular Anthropology and Microbiome Research, Norman, OK, 73019.

In this study, we sought to document the efficiency of primer extension capture (PEC) as a method to enrich DNA eluates of targeted DNA molecules and remove nontarget molecules from pools containing both. Efficiency of the method was estimated by comparing number of "copies in" to "copies out" by quantitative polymerase chain reaction. PEC retention of DNA targets ranging 109-288 base pairs (bps) in length was 15. Read More

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December 2018

Extended Duration of Hyperglycemia Result in Human-Like Corneal Nerve Lesions in Mice With Alloxan- and Streptozotocin-Induced Type 1 Diabetes.

Invest Ophthalmol Vis Sci 2018 Dec;59(15):5868-5875

Laboratory of Pathology, Faculty of Pharmaceutical Science, Setsunan University, Osaka, Japan.

Purpose: Previous experimental studies assessing corneal nerves as a measure of the severity of diabetic peripheral neuropathy have yielded discordant results; this may have been due to the effect of the short duration of the induced diabetes. We investigated whether increases in the duration of hyperglycemia result in the development of corneal lesions in a mouse model of alloxan (AL)- or streptozotocin (STZ)-induced type 1 diabetes. We further determined whether corneal nerve fiber density, intraepidermal nerve fiber density (IENFD), and sural nerve morphology can be used as morphologic markers of diabetic peripheral neuropathy in rodent models. Read More

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December 2018

Stochastic resonance improves visuomotor temporal integration in healthy young adults.

PLoS One 2018 14;13(12):e0209382. Epub 2018 Dec 14.

Neurorehabilitation Research Center, Kio University, Nara, Japan.

Mechanical and electrical noise stimulation to the body is known to improve the sensorimotor system. This improvement is related to stochastic resonance (SR), a phenomenon described as a "noise benefit" to various sensory and motor systems. The current study investigated the influence of SR on visuomotor temporal integration and hand motor function under delayed visual feedback in healthy young adults. Read More

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December 2018

Multiscale computational model of Achilles tendon wound healing: Untangling the effects of repair and loading.

PLoS Comput Biol 2018 Dec 14;14(12):e1006652. Epub 2018 Dec 14.

Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, United States of America.

Mechanical stimulation of the healing tendon is thought to regulate scar anisotropy and strength and is relatively easy to modulate through physical therapy. However, in vivo studies of various loading protocols in animal models have produced mixed results. To integrate and better understand the available data, we developed a multiscale model of rat Achilles tendon healing that incorporates the effect of changes in the mechanical environment on fibroblast behavior, collagen deposition, and scar formation. Read More

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December 2018

Detection of size of manufactured sand particles based on digital image processing.

PLoS One 2018 14;13(12):e0206135. Epub 2018 Dec 14.

Department of Radiation Oncology, Xiamen Cancer Hospital, First Affiliated Hospital of Xiamen University, Xiamen, Fujian Province, China.

The size distribution of manufactured sand particles has a significant influence on the quality of concrete. To overcome the shortcomings of the traditional vibration-sieving method, a manufactured sand casting/dispersing system was developed, based on the characteristics of the sand particle contours (as determined by backlit image acquisition) and an extraction mechanism. Algorithms for eliminating particles from the image that had be repeatedly captured, as well as for identifying incomplete particles at the boundaries of the image, granular contour segmentation, and the determination of an equivalent particle size, are studied. Read More

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December 2018

Augmented ILT3/LILRB4 Expression of Peripheral Blood Antibody Secreting Cells in the Acute-Phase of Kawasaki Disease.

Pediatr Infect Dis J 2018 Dec 13. Epub 2018 Dec 13.

Department of Pediatrics, Sendai Medical Center, 2-8-8 Miyagino, Sendai 983-8520, Japan.

Background: Kawasaki disease (KD) is an acute, systemic vasculitis syndrome that occurs in children. The clinical symptoms and epidemiological features of KD strongly suggest that KD is triggered by unidentified infectious agents in genetically predisposed patients. In addition, a number of studies have described the role of B cells in the development of KD. Read More

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December 2018

Structural deciphering of the NG2/CSPG4 proteoglycan multifunctionality.

FASEB J 2018 Dec 14:fj201801670R. Epub 2018 Dec 14.

Centre for Molecular and Translational Oncology (COMT), University of Parma, Parma, Italy.

The chondroitin sulfate proteoglycan 4 ( CSPG4) gene encodes a transmembrane proteoglycan (PG) constituting the largest and most structurally complex macromolecule of the human surfaceome. Its transcript shows an extensive evolutionary conservation and, due to the elaborated intracellular processing of the translated protein, it generates an array of glycoforms with the potential to exert variant-specific functions. CSPG4-mediated molecular events are articulated through the interaction with more than 40 putative ligands and the concurrent involvement of the ectodomain and cytoplasmic tail. Read More

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December 2018

Distinction of sporadic and familial forms of ALS based on mitochondrial characteristics.

FASEB J 2018 Dec 14:fj201801843R. Epub 2018 Dec 14.

Laboratory of Bioenergetics and Biomembranes, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland.

Bioenergetic failure, oxidative stress, and changes in mitochondrial morphology are common pathologic hallmarks of amyotrophic lateral sclerosis (ALS) in several cellular and animal models. Disturbed mitochondrial physiology has serious consequences for proper functioning of the cell, leading to the chronic mitochondrial stress. Mitochondria, being in the center of cellular metabolism, play a pivotal role in adaptation to stress conditions. Read More

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December 2018

The relationship between second language acquisition and nonverbal cognitive abilities.

J Exp Psychol Gen 2018 Dec 13. Epub 2018 Dec 13.

Department of Experimental Psychology.

We monitored the progress of 40 children when they first started to acquire a second language (L2) implicitly through immersion. Employing a longitudinal design, we tested them before they had any notions of an L2 (Time 0) and after 1 school year of L2 exposure (Time 1) to determine whether cognitive abilities can predict the success of L2 learning. Task administration included measures of intelligence, cognitive control, and language skills. Read More

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December 2018

Handshaking promotes deal-making by signaling cooperative intent.

J Pers Soc Psychol 2018 Dec 13. Epub 2018 Dec 13.

Department of Marketing, Harvard Business School.

We examine how a simple handshake-a gesture that often occurs at the outset of social interactions-can influence deal-making. Because handshakes are social rituals, they are imbued with meaning beyond their physical features. We propose that during mixed-motive interactions, a handshake is viewed as a signal of cooperative intent, increasing people's cooperative behavior and affecting deal-making outcomes. Read More

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December 2018

How mindfulness training promotes positive emotions: Dismantling acceptance skills training in two randomized controlled trials.

J Pers Soc Psychol 2018 Dec;115(6):944-973

Department of Psychology, Carnegie Mellon University.

Mindfulness meditation interventions-which train skills in monitoring present-moment experiences with a lens of acceptance-have shown promise for increasing positive emotions. Using a theory-based approach, we hypothesized that learning acceptance skills in mindfulness interventions helps people notice more positive experiences in daily life, and tested whether removing acceptance training from mindfulness interventions would eliminate intervention-related boosts in positive affect. In 2 randomized controlled trials (RCTs) of stressed community adults, mindfulness skills were dismantled into 2 structurally equivalent interventions: (a) training in both monitoring and acceptance (Monitor + Accept) and (b) training in monitoring only (Monitor Only) without acceptance training. Read More

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December 2018

Timing of antisynchronous calling: A case study in a harbor seal pup (Phoca vitulina).

Authors:
Andrea Ravignani

J Comp Psychol 2018 Dec 13. Epub 2018 Dec 13.

Research Department, Sealcentre Pieterburen.

Alternative mathematical models predict differences in how animals adjust the timing of their calls. Differences can be measured as the effect of the timing of a conspecific call on the rate and period of calling of a focal animal, and the lag between the two. Here, I test these alternative hypotheses by tapping into harbor seals' (Phoca vitulina) mechanisms for spontaneous timing. Read More

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December 2018

Modelling on Fragmentation of Clusters Inside a Mass Spectrometer.

J Phys Chem A 2018 Dec 14. Epub 2018 Dec 14.

Atmospheric clusters are weakly bound and can fragment inside the measuring instruments, particularly, mass spectrometers. Since the clusters accelerate under electric fields, the fragmentation cannot be described in terms of rate constants under equilibrium conditions. Using basic statistical principles, we have developed a model for fragmentation of clusters moving under an external force. Read More

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December 2018

Structural and Physical Properties of ZrSi under High Pressure: Experimental Study and First-Principles Calculations.

Inorg Chem 2018 Dec 14. Epub 2018 Dec 14.

High Pressure Science and Engineering Center , University of Nevada, Las Vegas , Las Vegas , Nevada 89154 , United States.

Zirconium disilicide (ZrSi) has been investigated experimentally and theoretically for its structural and physical properties at high pressures. In situ compression experiments demonstrate that at low pressure, ZrSi adopts the C49 structure (space group Cmcm), which persists up to 54.5 GPa at room temperature, and the unit cell of ZrSi along b-axis is at least twice as compressible as along a- and c-axis. Read More

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December 2018
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