1,428,675 results match your criteria Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation[Journal]


Bi-frequency symmetry difference electrical impedance tomography - a novel technique for perturbation detection in static scenes.

Physiol Meas 2019 Feb 20. Epub 2019 Feb 20.

Electrical and Electronic Engineering, National University of Ireland - Galway, Galway, Galway, IRELAND.

Objective: A novel method for the imaging of static scenes using Electrical Impedance Tomography (EIT) is reported with implementation and validation using numerical and phantom models. The technique is applicable to regions featuring symmetry in the normal case, asymmetry in the presence of a perturbation, and where there is a known, frequency-dependent change in the electrical conductivity of the materials in the region.

Methods: The stroke diagnostic problem is used as a motivating sample application. Read More

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http://dx.doi.org/10.1088/1361-6579/ab08baDOI Listing
February 2019

The effect of fermented superphosphate pretreatment and step-feed mode on biological denitrification of piggery wastewater.

Sci Total Environ 2019 Feb 1;665:724-730. Epub 2019 Feb 1.

College of Natural Resources and Environment, South China Agricultural University, Guangzhou 510642, China.

Chemical pretreatment can reduce NH-N levels in piggery wastewater to a certain extent, but the lack of a carbon source for subsequent biological treatment leads to a low denitrification efficiency and poor total nitrogen (TN) removal percentage. Taking superphosphate (SP) pretreatment (SP/Pretreatment) as the control, this research studies the influence of fermented superphosphate (FSP; SP plus a carbon source) pretreatment (FSP/Pretreatment) on biological denitrification in a subsequent biological treatment step. Furthermore, the removal of pollutants under different influent modes is also evaluated. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.02.005DOI Listing
February 2019

Assessing image artifacts from radiotherapy electromagnetic transponders with metal-artifact reduction imaging.

Magn Reson Imaging 2019 Feb 17. Epub 2019 Feb 17.

Department of Physics & Astronomy, University of Manitoba, Canada; Medical Physics, CancerCare Manitoba, Canada.

Image artifacts due to 14 gauge radiotherapy electromagnetic (EM) transponders were assessed on conventional spin echo images, and corrected using metal artifact reduction techniques: high bandwidth, view angle tilting (VAT), and slice encoding for metal artifact correction (SEMAC). Large areas of signal loss and/or pile-up were produced in an area extending up to 15.3 mm in radius for 14G transponders in standard imaging. Read More

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http://dx.doi.org/10.1016/j.mri.2019.02.005DOI Listing
February 2019

Reconstruction of effective connectivity in the case of asymmetric phase distributions.

J Neurosci Methods 2019 Feb 17. Epub 2019 Feb 17.

University of Cologne, Institute of Zoology, Heisenberg Research Group of Computational Neuroscience - Modeling Neural Network Function, Zülpicher Str. 47b, 50674 Cologne, Germany; Research Centre Jülich, Institute of Neuroscience and Medicine (INM-3), Cognitive Neuroscience, 52425 Jülich, Germany. Electronic address:

Background: The interaction of different brain regions is supported by transient synchronization between neural oscillations at different frequencies. Different measures based on synchronization theory are used to assess the strength of the interactions from experimental data. One method of estimating the effective connectivity between brain regions, within the framework of the theory of weakly coupled phase oscillators, was implemented in Dynamic Causal Modelling (DCM) for phase coupling (Penny et al. Read More

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http://dx.doi.org/10.1016/j.jneumeth.2019.02.009DOI Listing
February 2019

Membrane Electroporation and Electropermeabilization: Mechanisms and Models.

Annu Rev Biophys 2019 Feb 20. Epub 2019 Feb 20.

Faculty of Electrical Engineering, University of Ljubljana , SI-1000 Ljubljana, Slovenia; email: ,

Exposure of biological cells to high-voltage, short-duration electric pulses causes a transient increase in their plasma membrane permeability, allowing transmembrane transport of otherwise impermeant molecules. In recent years, large steps were made in the understanding of underlying events. Formation of aqueous pores in the lipid bilayer is now a widely recognized mechanism, but evidence is growing that changes to individual membrane lipids and proteins also contribute, substantiating the need for terminological distinction between electroporation and electropermeabilization. Read More

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http://dx.doi.org/10.1146/annurev-biophys-052118-115451DOI Listing
February 2019

Kinetics of Drug Binding and Residence Time.

Annu Rev Phys Chem 2019 Feb 20. Epub 2019 Feb 20.

Department of Pharmacy and Biotechnology, University of Bologna, I-40126 Bologna, Italy; email:

The kinetics of drug binding and unbinding is assuming an increasingly crucial role in the long, costly process of bringing a new medicine to patients. For example, the time a drug spends in contact with its biological target is known as residence time (the inverse of the kinetic constant of the drug-target unbinding, 1/ k). Recent reports suggest that residence time could predict drug efficacy in vivo, perhaps even more effectively than conventional thermodynamic parameters (free energy, enthalpy, entropy). Read More

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http://dx.doi.org/10.1146/annurev-physchem-042018-052340DOI Listing
February 2019

Development and Applications of Bioluminescent and Chemiluminescent Reporters and Biosensors.

Annu Rev Anal Chem (Palo Alto Calif) 2019 Feb 20. Epub 2019 Feb 20.

Center for Membrane and Cell Physiology, Department of Molecular Physiology and Biological Physics, and Department of Chemistry, University of Virginia, Charlottesville, Virginia 22908, USA; email:

Although fluorescent reporters and biosensors have become indispensable tools in biological and biomedical fields, fluorescence measurements require external excitation light, thereby limiting their use in thick tissues and live animals. Bioluminescent reporters and biosensors may potentially overcome this hurdle because they use enzyme-catalyzed exothermic biochemical reactions to generate excited-state emitters. This review first introduces the development of bioluminescent reporters, and next, their applications in sensing biological changes in vitro and in vivo as biosensors. Read More

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http://dx.doi.org/10.1146/annurev-anchem-061318-115027DOI Listing
February 2019

Peptide Sequence Influence on the Differentiation of Valine and Norvaline by Hot Electron Capture Dissociation.

Anal Chem 2019 Feb 20. Epub 2019 Feb 20.

Isomeric amino acid residues such as valine (Val) and norvaline (Nva) are common in recombinant proteins. The misincorporation of norvaline for Leucine causes heterogeneity and in some cases even toxicity. Previous studies have shown that hot electron capture dissociation (HECD) is able to differentiate Val from Nva by producing diagnostic w ions on custom designed synthetic model peptides. Read More

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http://dx.doi.org/10.1021/acs.analchem.8b04808DOI Listing
February 2019

Sultans of Swing: A Reappraisal of the Intertwined Association Between Affective Lability and Mood Reactivity in a Post Hoc Analysis of the BRIDGE-II-MIX Study.

J Clin Psychiatry 2019 Feb 19;80(2). Epub 2019 Feb 19.

Bipolar Disorder Unit, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain.

Objective: This post hoc analysis of the BRIDGE-II-MIX study is aimed at evaluating affective lability (AL) as a possible clinical feature of mixed depression and assessing the relationship with atypical depressive features, particularly mood reactivity (MR).

Methods: In the BRIDGE-II-MIX multicenter, cross-sectional study, 2,811 individuals suffering from a major depressive episode (MDE; DSM-IV-TR criteria), in the context of bipolar I or II disorder (BD-I, BD-II, respectively) or major depressive disorder, were enrolled between June 2009 and July 2010. Patients with (MDE-AL, n = 694) and without (MDE-noAL, n = 1,883) AL and with (MDE-MR, n = 1,035) or without (MDE-noMR, n = 1,542) MR were compared through χ² test or Student t test. Read More

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https://www.psychiatrist.com/JCP/article/Pages/2019/v80/17m1
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http://dx.doi.org/10.4088/JCP.17m12082DOI Listing
February 2019
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Drug Discovery for Pemphigoid Diseases.

Curr Protoc Pharmacol 2019 Feb 20:e55. Epub 2019 Feb 20.

Lübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany.

Pemphigoid diseases (PDs) are a group of autoimmune bullous diseases characterized and caused by autoantibodies targeting structural proteins of the skin and mucous membranes. Chronic inflammation, subepidermal blistering, and often scaring are the clinical characteristics of PDs. Itching and, in severe cases, disabilities resulting from scaring (i. Read More

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http://dx.doi.org/10.1002/cpph.55DOI Listing
February 2019

An explicit microFE approach to investigate the post-yield behaviour of trabecular bone under large deformations.

Int J Numer Method Biomed Eng 2019 Feb 20:e3188. Epub 2019 Feb 20.

Institute for Surgical Technology and Biomechanics, University of Bern, Stauffacherstr. 78, Bern, CH-3014, Switzerland.

Homogenised finite element (FE) analyses are able to predict osteoporosis-related bone fractures and become useful for clinical applications. The predictions of FE analyses depend on the apparent, heterogeneous, anisotropic, elastic and yield material properties, which are typically determined by implicit μFE analyses of trabecular bone. The objective of this study is to explore an explicit μFE approach to determine the apparent post-yield behaviour of trabecular bone, beyond the elastic and yield properties. Read More

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http://dx.doi.org/10.1002/cnm.3188DOI Listing
February 2019

Integrating Bacterial ChIP-seq and RNA-seq Data With SnakeChunks.

Curr Protoc Bioinformatics 2019 Feb 20:e72. Epub 2019 Feb 20.

Aix-Marseille University, INSERM, Laboratory of Theory and Approaches of Genome Complexity (TAGC), Marseille, France.

Next-generation sequencing (NGS) is becoming a routine approach in most domains of the life sciences. To ensure reproducibility of results, there is a crucial need to improve the automation of NGS data processing and enable forthcoming studies relying on big datasets. Although user-friendly interfaces now exist, there remains a strong need for accessible solutions that allow experimental biologists to analyze and explore their results in an autonomous and flexible way. Read More

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http://doi.wiley.com/10.1002/cpbi.72
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http://dx.doi.org/10.1002/cpbi.72DOI Listing
February 2019
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Bundled Defect-Rich MoS for a High-Rate and Long-Life Sodium-Ion Battery: Achieving 3D Diffusion of Sodium Ion by Vacancies to Improve Kinetics.

Small 2019 Feb 20:e1805405. Epub 2019 Feb 20.

Shaannxi Materials Analysis and Research Center, State Key Laboratory of Solidification Processing, School of Materials Science, Northwestern Polytechnical University, Xi'an, 710072, China.

Molybdenum disulfide (MoS ), a 2D-layered compound, is regarded as a promising anode for sodium-ion batteries (SIBs) due to its attractive theoretical capacity and low cost. The main challenges associated with MoS are the low rate capability suffering from the sluggish kinetics of Na intercalation and the poor cycling stability owning to the stack of MoS sheets. In this work, a unique architecture of bundled defect-rich MoS (BD-MoS ) that consists of MoS with large vacancies bundled by ultrathin MoO is achieved via a facile quenching process. Read More

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http://dx.doi.org/10.1002/smll.201805405DOI Listing
February 2019

pH-Responsive Pillar[6]arene-based Water-Soluble Supramolecular Hexagonal Boxes.

Angew Chem Int Ed Engl 2019 Feb 20. Epub 2019 Feb 20.

Tel Aviv University, School of Chemistry, Ramat Aviv, 69978, Tel Aviv, ISRAEL.

We describe the preparation of the first water-soluble pH-responsive supramolecular hexagonal boxes (SHBs) based on multiple charge-assisted hydrogen bonds between peramino-pillar[6]arenes 2 with the molecular "lid" mellitic acid (1a). The interaction between 2 and 1a, as well as the other "lids" pyromellitic and trimesic acids (1b and 1c, respecively) were studied by a combination of experimental and computational methods. Interestingly, the addition of 1a to the complexes of the protonated form of pillar[6]arene 2, i. Read More

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http://dx.doi.org/10.1002/anie.201900217DOI Listing
February 2019

Electron-Deficient Triborane and Tetraborane Ring Compounds: Synthesis, Structure and Bonding.

Angew Chem Int Ed Engl 2019 Feb 20. Epub 2019 Feb 20.

Ruprecht-Karls-Universität Heidelberg, Institut für Anorganische Chemie, Im Neuenheimer Feld 270, 69120, Heidelberg, GERMANY.

Electron-deficient small boron rings are unique in their formation of sigma- and pi-delocalized electron systems, and the avoidance of "classical" structures in terms of two-center-two-electron (2c,2e) bonds. These rings are tolerant to several skeletal electron numbers, making their redox-chemistry highly interesting. In the past decades, the synthesis of a range of stable compounds with varying electron numbers in the B3 and B4 cores was achieved. Read More

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http://dx.doi.org/10.1002/anie.201900563DOI Listing
February 2019

Rapid and sustained immune tolerance to inhibitors induced by a plasma-derived, VWF-containing FVIII concentrate.

Haemophilia 2019 Feb 20. Epub 2019 Feb 20.

Hematology Department, Hospital Universitario La Paz, Universidad Autónoma de Madrid, Madrid, Spain.

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http://dx.doi.org/10.1111/hae.13676DOI Listing
February 2019

HspBP1 and anti-HspBP1 levels in the serum of HIV-infected individuals are associated to the disease progression.

J Appl Microbiol 2019 Feb 20. Epub 2019 Feb 20.

Laboratory of Cellular and Molecular Immunology - Federal University of Health Sciences of Porto Alegre, Av. Sarmento Leite, 245, Centro Historico, 90050-170, Porto Alegre, RS, Brazil.

Aims: The objective of this research was to quantify the levels of circulating HspBP1 and anti-HspBP1 IgG in HIV-infected individuals and to correlate them with CD4 T cell counts and viral load, as well as to determine the kinetics of those proteins during acute phase.

Methods And Results: Sixty serum samples from HIV-positive outpatients, thirty with high viral load and thirty with low viral load were analyzed. The HspBP1and anti-HspBP1 were quantified by ELISA. Read More

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http://dx.doi.org/10.1111/jam.14230DOI Listing
February 2019

Coordinating Tissue Regeneration through TGF-β Activated Kinase 1 (TAK1) In-activation and Re-activation.

Stem Cells 2019 Feb 20. Epub 2019 Feb 20.

Department of Surgery, University of Michigan, Ann Arbor, Michigan.

Aberrant wound healing presents as inappropriate or insufficient tissue formation. Using a model of musculoskeletal injury, we demonstrate that loss of TGF-β activated kinase 1 (TAK1) signaling reduces inappropriate tissue formation (heterotopic ossification) through reduced cellular differentiation. Upon identifying increased proliferation with loss of TAK1 signaling, we considered a regenerative approach to address insufficient tissue production through coordinated inactivation of TAK1 to promote cellular proliferation, followed by re-activation to elicit differentiation and extracellular matrix (ECM) production. Read More

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http://dx.doi.org/10.1002/stem.2991DOI Listing
February 2019

The use of human and bovine commercial media for oocyte maturation and embryo development in the domestic cat (Felis catus).

Reprod Domest Anim 2019 Feb 20. Epub 2019 Feb 20.

Foundation Municipal Park and the Zoological Garden in Cracow, ul. Kasy Oszczędności Miasta Krakowa 14, 30-232, Kraków.

The aim of this study was to examine the suitability of commercial media designed for humans and cattle for oocyte maturation and embryo culture in the domestic cat. In Exp. I, feline oocytes collected ex vivo were subjected to in vitro maturation in a laboratory-made culture medium (based on M199) or a commercial medium designed for cattle cells (BO-IVM ). Read More

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http://dx.doi.org/10.1111/rda.13418DOI Listing
February 2019

Effect of a mHealth program on coronary heart disease prevention among working population in Singapore: a single group pretest-posttest design.

J Adv Nurs 2019 Feb 20. Epub 2019 Feb 20.

Alice Lee Centre for Nursing Studies, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

Aim: To develop and examine the effectiveness of a 4-week mHealth program using the smartphone app Care4Heart on awareness, knowledge, perceived stress and a heart-related lifestyle among working population in Singapore.

Design: A quasi-experimental single group pre- and repeated post-test design.

Methods: A total of 160 nonhealth-related working adults were recruited from February 2016 - April 2016. Read More

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http://dx.doi.org/10.1111/jan.13980DOI Listing
February 2019

Riluzole promotes neurological function recovery and inhibits damage extension in rats following spinal cord injury: a meta-analysis and systematic review.

J Neurochem 2019 Feb 20. Epub 2019 Feb 20.

Spine Disease Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China.

Spinal cord injury (SCI) is a devastating condition that has few treatment options. Riluzole, a sodium channel blocker used to treat amyotrophic lateral sclerosis, has been initially trialed in human SCI. We performed a systematic review to critically assess the efficacy of riluzole in locomotor recovery and damage extension in SCI rat models, and the potential for clinical translation. Read More

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http://dx.doi.org/10.1111/jnc.14686DOI Listing
February 2019

Editorial: Can dysregulated myelination be linked to ADHD pathogenesis and persistence?

J Child Psychol Psychiatry 2019 Mar;60(3):229-231

Converging evidence from new epidemiologic, genetic, epigenetic, neuroimaging, and experimental model findings are further refining a long-standing concept, regarding the underlying neurobiology of attention-deficit/hyperactivity disorder (ADHD): that ADHD onset and its persistence into adulthood are the result of dysregulated myelination and associated alterations in neuronal plasticity - linked to disrupted brain maturation and the persistence of cognitive and emotional impairments across the life span. If supported by further work, this concept represents a pathophysiologic mechanism amenable to therapeutic intervention. Read More

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http://dx.doi.org/10.1111/jcpp.13031DOI Listing

Molecular features of steroid-binding antidins and their use for assaying serum progesterone.

PLoS One 2019 20;14(2):e0212339. Epub 2019 Feb 20.

Structural Bioinformatics Laboratory, Biochemistry, Faculty of Science and Engineering, Åbo Akademi University, Turku, Finland.

Chicken avidin (Avd) and streptavidin from Streptomyces avidinii are extensively used in bionanotechnology due to their extremely tight binding to biotin (Kd ~ 10-15 M for chicken Avd). We previously reported engineered Avds known as antidins, which have micro- to nanomolar affinities for steroids, non-natural ligands of Avd. Here, we report the 2. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212339PLOS
February 2019

Sexual dimorphism of acute doxorubicin-induced nephrotoxicity in C57Bl/6 mice.

PLoS One 2019 20;14(2):e0212486. Epub 2019 Feb 20.

Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota, United States of America.

Doxorubicin (DOX) is a chemotherapeutic agent that has been reported to cause nephrotoxicity in rodent models and to a lesser degree in cancer patients. Female rodents have been shown to be protected against several features of DOX-induced nephrotoxicity. Nevertheless, the underlying mechanisms of this sexual dimorphism are not fully elucidated. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212486PLOS
February 2019

Socioeconomic gap between neighborhoods of Budapest: Striking impact on stroke and possible explanations.

PLoS One 2019 20;14(2):e0212519. Epub 2019 Feb 20.

Semmelweis University, Department of Neurology, Budapest, Hungary.

Introduction: Hungary has a single payer health insurance system offering free healthcare for acute cerebrovascular disorders. Within the capital, Budapest, however there are considerable microregional socioeconomic differences. We hypothesized that socioeconomic deprivation reflects in less favorable stroke characteristics despite universal access to care. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212519PLOS
February 2019

Development of a human milk concentrate with human milk lyophilizate for feeding very low birth weight preterm infants: A preclinical experimental study.

PLoS One 2019 20;14(2):e0210999. Epub 2019 Feb 20.

Department of Pediatrics, Neonatology, Children´s Hospital, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.

Breast milk is considered the gold standard nutritional resource for very low birth weight (VLBW) infants in terms of nutrients and protective factors. If mother's milk is not available, the second choice is donated and fortified human milk (HM) from the Human Milk Bank (HMB). This study hypothesized that HM could be lyophilized and used as an additive to increase the levels of macronutrients and micronutrients available to VLBW infants. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210999PLOS
February 2019

Does aerobic exercise associated with tryptophan supplementation attenuates hyperalgesia and inflammation in female rats with experimental fibromyalgia?

PLoS One 2019 20;14(2):e0211824. Epub 2019 Feb 20.

Department of Physical Education, Federal University of Viçosa, Viçosa, MG-Brazil.

The objective of this study was to verify the effects of aerobic exercise associated with tryptophan (TRP) supplementation on hyperalgesia, as well as on cortisol, IL-6 and TNF concentrations in female rats with experimental fibromyalgia (FM). Female Wistar rats (initial body weight: ~ 350 g; age: 12 months) were randomly divided into 5 groups: CON (Control); F (Fibromyalgia induced); FE (Fibromyalgia induced plus exercise); FES (Fibromyalgia induced plus exercise and TRP supplementation) and FS (Fibromyalgia induced plus TRP supplementation). Fibromyalgia was induced with two injections (20 μL) of acidic saline (pH 4. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211824PLOS
February 2019

Mandarin Chinese modality exclusivity norms.

PLoS One 2019 20;14(2):e0211336. Epub 2019 Feb 20.

Department of Chinese and Bilingual Studies, The Hong Kong Polytechnic University, Kowloon, Hong Kong.

Modality exclusivity norms have been developed in different languages for research on the relationship between perceptual and conceptual systems. This paper sets up the first modality exclusivity norms for Chinese, a Sino-Tibetan language with semantics as its orthographically relevant level. The norms are collected through two studies based on Chinese sensory words. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211336PLOS
February 2019

Effects of aerobic exercise on molecular aspects of asthma: involvement of SOCS-JAK-STAT.

Exerc Immunol Rev 2019 ;25:50-62

Universidade Brasil, Post-graduation Program in Bioengineering and in Biomedical Engineering, Campus Itaquera, Rua Carolina Fonseca 235, São Paulo - SP, Brazil, 08230-030. Brazilian Institute of Teaching and Research in Pulmonary and Exercise Immunology (IBEPIPE). Rua Pedro Ernesto 240, São José dos Campos - SP, Brazil, 12245-520. Post-Graduation Program in Sciences of Human Movement and Rehabilitation, Federal University of Sao Paulo (UNIFESP), Campus Baixada Santista, Av. Ana Costa, 95 - Vila Mathias - Santos/SP - CEP: 11060-001.

Background: Aerobic training (AT) decreases airway inflammation in asthma, but the underlying cellular and molecular mechanisms are not completely understood. Thus, this study evaluated the participation of SOCS-JAK-STAT signaling in the effects of AT on airway inflammation, remodeling and hyperresponsiveness in a model of allergic airway inflammation.

Methods: C57Bl/6 mice were divided into Control (Co), Exercise (Ex), HDM (HDM), and HDM+Exercise (HDM+ Ex). Read More

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January 2019

Unconscious Detection of One's Own Image.

Psychol Sci 2019 Feb 20:956797618822971. Epub 2019 Feb 20.

1 Laboratory of Language Neurobiology, Nencki Institute of Experimental Biology of Polish Academy of Sciences.

A key mechanism behind preferential processing of self-related information might be an early and automatic capture of attention. Therefore, the present study tested a hypothesis that one's own face will attract bottom-up attention even without conscious identification. To test this, we used a dot-probe paradigm with electrophysiological recordings, in which participants ( N = 18) viewed masked and unmasked pairs of faces (other, self) presented laterally. Read More

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http://dx.doi.org/10.1177/0956797618822971DOI Listing
February 2019

Discriminating between anticipatory and visually triggered saccades: Measuring minimal visual saccadic response time using luminance.

J Neurophysiol 2019 Feb 20. Epub 2019 Feb 20.

Queens University, Canada.

We describe a novel behavioral method to accurately discriminate anticipatory (i.e., saccades are not generated by visual input) from visually triggered saccades and to identify the minimal visual saccadic reaction time (SRT). Read More

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http://dx.doi.org/10.1152/jn.00378.2018DOI Listing
February 2019

Renal Cortical Perfusion, Measured by Superb Microvascular Imaging, During Infusion of Norepinephrine in Experimental Cardiopulmonary Bypass.

Am J Respir Crit Care Med 2019 Feb 20. Epub 2019 Feb 20.

The Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia.

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http://dx.doi.org/10.1164/rccm.201807-1275IMDOI Listing
February 2019

The Effect of Cold Ambient Temperature and Preceding Active Warm-up on Lactate Kinetics in Female Cyclists and Triathletes.

Appl Physiol Nutr Metab 2019 Feb 20. Epub 2019 Feb 20.

Florida State University, Tallahasse, Florida, United States.

Purpose: To evaluate the effect of cold ambient temperature on lactate kinetics with and without a preceding warm-up in female cyclists/triathletes.

Methods: Seven female cyclists/triathletes participated in this study. The randomized, cross-over study included three experimental visits that consisted of the following conditions: 1) thermoneutral temperature (20ºC, NEU); 2) cold temperature (0ºC) with no active warm-up (CNWU); and 3) cold temperature (0ºC) with 25 min active warm-up (CWU). Read More

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http://dx.doi.org/10.1139/apnm-2018-0698DOI Listing
February 2019

Monte Carlo Molecular Modeling of Temperature and Pressure Effects on the Interactions between Crystalline Calcium Silicate Hydrate Layers.

Authors:
Tulio Honorio

Langmuir 2019 Feb 20. Epub 2019 Feb 20.

The interactions of calcium silicate hydrates with water are at the heart of critical features of cement-based materials behavior such as drying and autogenous shrinkage, hysteresis, creep and thermal expansion. In this article, the interactions between nanocrystalline layers of calcium silicate hydrates are computed from Grand Canonical Monte Carlo (GCMC) molecular simulations. The effects of temperature, chemical potential and pressure on these interactions are studied. Read More

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http://dx.doi.org/10.1021/acs.langmuir.8b04156DOI Listing
February 2019

The Stefan-Reynolds model and the modified Stefan-Reynolds model for studying bubble-particle attachment interactions in the context of flotation.

Langmuir 2019 Feb 20. Epub 2019 Feb 20.

Bubble-particle attachment is the key step for successful flotation. Modelling of attachment interactions between air bubbles and particles after their collision can be analysed using the Stefan-Reynolds model (immobile bubble surfaces) and the modified Stefan-Reynolds model (mobile bubble surfaces). However, these models have been rarely used, and the limitations of these models have not yet been reported. Read More

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http://dx.doi.org/10.1021/acs.langmuir.9b00397DOI Listing
February 2019

Experimental Evidence for a Cluster Glass Transition in Concentrated Lysozyme Solutions.

J Phys Chem B 2019 Feb 20. Epub 2019 Feb 20.

Lysozyme is known to form equilibrium clusters at a pH≈7.8 and at low ionic strength as a result of a mixed potential. While this cluster formation and the related dynamic and static structure factors have been extensively investigated, its consequences on the macroscopic dynamic behavior expressed by the zero shear viscosity η remain controversial. Read More

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http://dx.doi.org/10.1021/acs.jpcb.8b11781DOI Listing
February 2019

Unraveling Concomitant Packing Polymorphism in Metallosupramolecular Polymers.

J Am Chem Soc 2019 Feb 20. Epub 2019 Feb 20.

The phenomenon of polymorphism is ubiquitous in biological systems and has been also observed in various types of self-assembled materials in solution and the solid state. In the field of supramolecular polymers, different kinetic vs. thermodynamic self-assembled species may exist in competition, a phenomenon termed as pathway complexity. Read More

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http://pubs.acs.org/doi/10.1021/jacs.8b11011
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http://dx.doi.org/10.1021/jacs.8b11011DOI Listing
February 2019
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[Novel hepatokine in rheumatoid arthritis laboratory diagnostics.]

Klin Lab Diagn 2018 ;63(12):756-760

Federal State Budgetary Institution Institute of Clinical and Experimental Rheumatology named after A.B. Zborovsky, Volgograd.

Fetuin-A (α2-Heremans-Schmid glycoprotein, AHSG) is a glycoprotein mainly secreted by hepar in adults. It was shown, that AHSG is a positive as well as a negative acute-phase protein with pro- and anti-inflammatory effects. We studied serum levels of an AHSG in patients with rheumatoid arthritis (RA) and healthy controls in order to determine its role in the diagnostics of this disease. Read More

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http://dx.doi.org/10.18821/0869-2084-2018-63-12-756-760DOI Listing
January 2018

NetSurfP-2.0: Improved prediction of protein structural features by integrated deep learning.

Proteins 2019 Feb 20. Epub 2019 Feb 20.

Department of Bio and Health Informatics, Technical University of Denmark, Kgs. Lyngby, Denmark.

The ability to predict local structural features of a protein from the primary sequence is of paramount importance for unravelling its function in absence of experimental structural information. Two main factors affect the utility of potential prediction tools: their accuracy must enable extraction of reliable structural information on the proteins of interest, and their runtime must be low to keep pace with sequencing data being generated at a constantly increasing speed. Here, we present NetSurfP-2. Read More

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http://dx.doi.org/10.1002/prot.25674DOI Listing
February 2019

CCL21-expression and accumulation of CCR7 NK cells in livers of patients with primary sclerosing cholangitis.

Eur J Immunol 2019 Feb 20. Epub 2019 Feb 20.

Research Department of Virus Immunology, Heinrich Pette Institute, Hamburg, Germany.

The pathogenesis of primary sclerosing cholangitis (PSC), an autoimmune liver disease, remains unknown. The aim of this study was to characterize peripheral blood and intrahepatic NK cells from patients with PSC. Peripheral blood samples from patients with PSC, other autoimmune liver diseases, and from healthy control individuals were used, as well as liver tissues from PSC patients undergoing liver transplantation. Read More

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http://dx.doi.org/10.1002/eji.201847965DOI Listing
February 2019

Experimental and modeling evidence of carbon limitation of leaf appearance rate for spring and winter wheat.

J Exp Bot 2019 Feb 20. Epub 2019 Feb 20.

LEPSE, Université Montpellier, INRA, Montpellier SupAgro, Montpellier, France.

Accurate predictions of the timing of physiological stages and the development rate are crucial for predicting crop performance under field conditions. Plant development is controlled by the leaf appearance rate (LAR) and our understanding of how LAR responds to environmental factors is still limited. Here, we tested the hypothesis that carbon availability may account for the effects of irradiance, photoperiod, atmospheric CO2 concentration, and ontogeny on LAR. Read More

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http://dx.doi.org/10.1093/jxb/erz012DOI Listing
February 2019

Experimental study on the action of larvicides in Aedes aegypti populations collected in the Brazilian municipality of Itabuna, Bahia, under simulated field conditions.

Epidemiol Serv Saude 2019 Feb 18;28(1):e2017316. Epub 2019 Feb 18.

Universidade Federal da Bahia, Instituto de Ciências da Saúde, Salvador, BA, Brasil.

Objective: to evaluate, under simulated field conditions, the efficacy of pyriproxyfen (juvenile hormone), novaluron (chitin inhibitor) and spinosad (biolarvicide) in controlling Aedes aegypti.

Methods: periodic exposition of Ae. aegypti larvae collected in Itabuna, BA, Brazil, to recipients treated with larvicides and comparison of residual effect of treatment with the Rockefeller strain. Read More

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http://dx.doi.org/10.5123/S1679-49742019000100004DOI Listing
February 2019

Arbovirus control: what is the (real) stone in the way?

Rev Inst Med Trop Sao Paulo 2019 Feb 14;61:e15. Epub 2019 Feb 14.

Fundação Oswaldo Cruz, Instituto Aggeu Magalhães, Departamento de Virologia e Terapia Experimental, Recife, Pernambuco, Brazil.

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http://dx.doi.org/10.1590/S1678-9946201961015DOI Listing
February 2019

Metronidazole concentration in the bloodstream following its topical application, at different concentration levels, on experimental skin wounds during healing by secondary intention1.

Acta Cir Bras 2019 Feb 14;34(1):e20190010000004. Epub 2019 Feb 14.

Associate Professor, Department of Surgery, and Permanent Instructor, Postgraduate in Surgical Medicine, UFPR, Curitiba-PR, Brazil. Technical procedures.

Purpose: To characterize qualitatively and quantitatively the absorption of metronidazole solution, in greater concentrations and for longer periods, when applied topically to an experimental open skin wound model.

Methods: An open skin wound, 2 cm in diameter and total skin thickness was prepared, under anesthetic, in the dorsal region of 108 Wistar rats weighing between 300 and 350 grams. The animals were allocated to groups of 18 animals in accordance with the concentration of metronidazole in the solution to be applied daily to the wound. Read More

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http://dx.doi.org/10.1590/s0102-865020190010000004DOI Listing
February 2019

An experimental study of exenatide effects on renal injury in diabetic rats1.

Acta Cir Bras 2019 Feb 14;34(1):e20190010000001. Epub 2019 Feb 14.

Master, Second Department of Endocrinology, Tai'an Central Hospital, China. Design of the study, critical revision, final approval.

Purpose: To investigate the effects of exenatide on renal injury in streptozotocin-induced diabetic rats.

Methods: Fifty SD rats were randomly divided into normal control, model, exenatide-1, exenatide-2 and exenatide-3 groups, 10 rats in each group. The diabetic nephropathy model was constructed in later 4 groups. Read More

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http://dx.doi.org/10.1590/s0102-865020190010000001DOI Listing
February 2019

Repercussions of low fructose-drinking water in male rats.

An Acad Bras Cienc 2019 Feb 14;91(1):e20170705. Epub 2019 Feb 14.

Laboratório de Fisiologia de Sistemas e Toxicologia Reprodutiva, Instituto de Ciências Biológicas e da Saúde, Universidade Federal de Mato Grosso/UFMT, Avenida Valdon Varjão, 6390, 78600-000 Barra do Garças, MT, Brazil.

Fructose consumption has increased worldwide, and it has been associated with the development of metabolic diseases such as insulin resistance (IR) and steatosis. The aim was to evaluate if lower fructose concentrations may cause pancreatic structural abnormalities, leading to a glucose intolerance without steatosis in male rats. Young male rats orally received 7% fructose solution for 12 weeks. Read More

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http://dx.doi.org/10.1590/0001-3765201920170705DOI Listing
February 2019
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Strong influence of weak hydrogen bonding on actinide-phosphonate complexation: accurate predictions from DFT followed by experimental validation.

Phys Chem Chem Phys 2019 Feb 20. Epub 2019 Feb 20.

Homi Bhabha National Institute, Indira Gandhi Centre for Atomic Research, Kalpakkam, Tamilnadu 603102, India.

Among the varied classes of weak hydrogen bond, the CHO type is one of immense interest as it governs the finer structures of biological and chemical molecules, hence determining their functionalities. In the present work, this weak hydrogen bond has been shown to strongly influence the complexation behaviour of uranyl nitrate [UO2(NO3)2] with diamyl-H-phosphonate (DAHP) and its branched isomer disecamyl-H-phosphonate (DsAHP). The structures of the bare ligands and complexes have been optimized by density functional theory (DFT) calculations. Read More

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http://dx.doi.org/10.1039/c9cp00479cDOI Listing
February 2019

Equilibrium structures of the tetramezine diastereomers and their ratio: joint analysis of gas phase electron diffraction, quantum chemistry, and spectroscopic data.

Phys Chem Chem Phys 2019 Feb 20. Epub 2019 Feb 20.

N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 119991 Moscow, Russia.

For the first time, we applied a gas-phase electron diffraction (GED) method together with vibrational spectroscopy and quantum chemical calculations to investigate the equilibrium geometries of achiral meso and enantiomeric diastereomers of tetramezine [1,2-bis-(3,3-dimethyldiaziridin-1-yl)ethane] and their ratio in the mixture. In the joint structural analysis of these data, a new approach based on PES parameters is used in the framework of a static molecular model (small amplitude motion approximation). The agreement between the theoretical and experimental molecular intensities is characterized by a divergence factor Rf of 5. Read More

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http://dx.doi.org/10.1039/c8cp07607cDOI Listing
February 2019

Membrane pore formation and ion selectivity of the Ebola virus delta peptide.

Phys Chem Chem Phys 2019 Feb 20. Epub 2019 Feb 20.

Department of Physics, Miami, FL 33199, USA and Biomolecular Sciences Institute Florida International University, Miami, FL 33199, USA.

The Ebola virus (EBOV) is a filamentous lipid-enveloped virus that causes severe hemorrhagic fever with a high fatality rate in humans. The EBOV encodes a glycoprotein that when cleaved, produces the delta peptide. Experimental evidence suggests that the delta peptide functions as a viroporin that enhances virus particle release through the host cell membrane. Read More

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http://dx.doi.org/10.1039/c8cp07323fDOI Listing
February 2019

Multimedia Appendix Correction: mHealth Supportive Care Intervention for Parents of Children With Acute Lymphoblastic Leukemia: Quasi-Experimental Pre- and Postdesign Study.

JMIR Mhealth Uhealth 2019 Feb 20;7(2):e13159. Epub 2019 Feb 20.

School of Nursing, Fudan University, Shanghai, China.

[This corrects the article DOI: 10.2196/mhealth.9981. Read More

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http://mhealth.jmir.org/2019/2/e13159/
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http://dx.doi.org/10.2196/13159DOI Listing
February 2019
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