501 results match your criteria Experimental and clinical cardiology[Journal]


Mechanosensitive Ion Channels in Cardiovascular Physiology.

Exp Clin Cardiol 2014;20(10):6550-6560. Epub 2014 Oct 29.

Laboraotry of Cell and Molecular Biology, University of Wisconsin - Madison, WI 53706, USA; Department of Genetics, University of Wisconsin - Madison, WI 53706.

EC coupling is subjected to a mechanical feedback, which originates from physical force-sensing ion channels in the pericardium and elsewhere. Reviewed here are the most recent developments that greatly advanced our understanding of these mechanosensitive (MS) channels, including TRPs and K's. Patch clamp has continued to demonstrate the direct channel activation by membrane stretch. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4713040PMC
October 2014
10 Reads

Detection of left ventricular asynchrony and its relationship with the Tei index in patients with coronary artery ectasia.

Exp Clin Cardiol 2013 ;18(1):e8-e11

Faculty of Medicine, Department of Cardiology, Abant Izzet Baysal University, Bolu;

Objective: To evaluate left ventricular (LV) systolic asynchrony and its relationship with the Tei index using tissue Doppler imaging (TDI); and to evaluate the relationship of thrombolysis in myocardial infarction frame count (TFC) and Tei index with LV asynchrony in patients with coronary artery ectasia (CAE).

Methods: A total of 50 CAE patients and 40 control subjects were evaluated. Diagnosis of CAE was made angiographically and TFC was calculated. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3716492PMC
December 2013
10 Reads
1 Citation
0.760 Impact Factor

Smooth muscle-like cells resident in the media participate in spasm-induced coronary intimal hyperplasia.

Exp Clin Cardiol 2013 ;18(1):e65-70

Department of Pathology, Toho University Medical Center Sakura Hospital, Sakura, Japan;

Background: Coronary intimal hyperplasia occurs at the site of spasm in patients with vasospastic angina. The migration of vascular smooth muscle cells (VSMCs) from the media has been proposed as a potential mechanism; however, this has not been confirmed with supportive evidence.

Objective: To determine which cell types participate in spasm-induced coronary intimal hyperplasia. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3716509PMC
December 2013
6 Reads

Omega-3 polyunsaturated fatty acid-enriched diet differentially protects two subpopulations of myocardial mitochondria against Ca(2+)-induced injury.

Exp Clin Cardiol 2013 ;18(1):e60-4

Department of General and Molecular Pathophysiology, AA Bogomoletz Institute of Physiology, Kiev, Ukraine.

Omega-3 polyunsaturated fatty acids (PUFA) confer protection against myocardial injury after ischemia-reperfusion. There are two subfractions of mitochondria located in different regions of the cell: subsarcolemmal mitochondria (SSM) and interfibrillar mitochondria (IFM). The present study explored possible differences between Ca(2+)-induced mitochondrial swelling in rat SSM and IFM fractions under control conditions (control group [CG]) and after dietary supplementation with omega-3 PUFA (experimental group [EG]). Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3716508PMC
December 2013
8 Reads

Cocaine-induced coronary stent thrombosis.

Exp Clin Cardiol 2013 ;18(1):e57-9

Division of Cardiology, University of Florida at Jacksonville, Jacksonville, Florida;

Cocaine is the most commonly abused drug in patients presenting to emergency rooms. Compliance with medical instructions and medications is poor in patients who use cocaine. A case involving a 41-year-old cocaine user who developed subacute stent thrombosis is described. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3716507PMC
December 2013
8 Reads

What lies beneath: Posterior ST elevation myocardial infarction with underlying right ventricular-paced rhythm.

Exp Clin Cardiol 2013 ;18(1):e55-6

Division of Cardiovascular Medicine, University of California, Davis, Davis, California, USA.

A 66-year-old man with a history of coronary artery disease, stage V chronic kidney disease, peripheral arterial disease and a dual-chamber pacemaker experienced persistent chest and shoulder discomfort following his daily hemodialysis treatment. Treatment with clopidogrel had been discontinued three days previously due to impending vascular surgery. Electrocardiography revealed a right ventricular-paced rhythm with ST abnormalities indicative of posterior ST elevation myocardial infarction. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3716506PMC
December 2013
8 Reads

Patent ductus arteriosus closure using an Amplatzer(™) ventricular septal defect closure device.

Exp Clin Cardiol 2013 ;18(1):e50-4

University of Texas Health Science Center at Houston, Houston, Texas, USA.

The ductus arteriosus originates from the persistence of the distal portion of the left sixth aortic arch. It connects the descending aorta (immediately distal to the left subclavian artery) to the roof of the main pulmonary artery, near the origin of the left pulmonary artery. Persistence of the duct beyond 48 h after birth is abnormal and results in patent ductus arteriosus (PDA). Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3716504PMC
December 2013
8 Reads

Mitral annulus calcification is independently associated with all-cause mortality.

Exp Clin Cardiol 2013 ;18(1):e5-7

University of Arizona School of Medicine, Tucson, Arizona, USA.

Background: Mitral annulus calcification (MAC) is an important echocardiographic finding that is significantly associated with valvular abnormalities. However, the effect of documented MAC on all-cause mortality is not known. Using a large database, associations between MAC and long-term all-cause mortality were evaluated. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3716491PMC
December 2013
4 Reads

Evaluation of left ventricular function, rotation, twist and untwist in patients with hypertrophic cardiomyopathy.

Exp Clin Cardiol 2013 ;18(1):e47-9

Department of Ultrasound, Ruian Maternity & Child Care Hospital, Ruian;

Hypertrophic cardiomyopathy (HCM) is a disease with an autosomal-dominant pattern of inheritance associated with a variety of disease courses, age of onset, symptom severity, left ventricular outflow obstruction and risk for sudden cardiac death. Left ventricular systolic function is typically normal in most HCM patients using conventional echocardiographic indexes; however, myocardial systolic and diastolic function are reduced, and the mechanism of myocardial dysfunction remains unclear. Echocardiography is an invaluable tool for the diagnosis and assessment of hemodynamic condition, evaluation of therapy and outcome, and follow-up of patients with HCM. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3716503PMC
December 2013
9 Reads

Abnormal myocardial perfusion and risk of heart failure in patients with type 2 diabetes mellitus.

Exp Clin Cardiol 2013 ;18(1):e44-6

HF Clinic, Instituto Nacional de Ciencias Médicas y Nutrición "Salvador Zubirán".

Background: Diabetes is a major risk factor for heart failure (HF), although the pathophysiological processes have not been clarified.

Objective: To determine the prevalence of HF and of abnormal myocardial perfusion in diabetic patients evaluated using technetium (99m) sestamibi single-photon emission computed tomography.

Methods: An observational cross-sectional study was conducted that included patients with type 2 diabetes mellitus who underwent echocardiography to diagnose HF and a pharmacological stress test with intravenous dipyridamole to examine cardiac scintigraphic perfusion abnormalities. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3716502PMC
December 2013
6 Reads

Atorvastatin improves endothelial progenitor cell function and reduces pulmonary hypertension in patients with chronic pulmonary heart disease.

Exp Clin Cardiol 2013 ;18(1):e40-3

Department of Health, Liaocheng People's Hospital of Taishan Medical University, Shandong Province, China;

Objective: To explore the effects of atorvastatin on the migration and adhesion of endothelial progenitor cells (EPCs) and on pulmonary artery pressure (PAP) in patients with chronic pulmonary heart disease.

Methods: A total of 68 patients with chronic pulmonary heart disease were randomly assigned to either a control group (n=35) or a treatment group (n=33). In addition, 30 healthy volunteers (17 male, 13 female) were enrolled as healthy controls. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3716501PMC
December 2013
7 Reads

Relationship between serum uric acid levels and ventricular function in patients with idiopathic pulmonary hypertension.

Exp Clin Cardiol 2013 ;18(1):e37-9

Department of Cardiac Surgery, Liaocheng People's Hospital of Taishan Medical University, Liaocheng, Shandong, People's Republic of China;

Objective: To investigate the relationship between serum uric acid levels and pulmonary hypertension in patients with idiopathic pulmonary artery hypertension (IPAH).

Methods: Serum uric acid levels were measured in 86 patients (mean [± SD] age 35.2±12. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3716500PMC
December 2013
26 Reads

Prevalence of mixed dyslipidemia among Australian patients undergoing lipid-modifying therapy.

Exp Clin Cardiol 2013 ;18(1):e32-6

University of Queensland, Brisbane, Australia;

Background: Few studies have assessed the prevalence of mixed dyslipidemia (MD) and the effectiveness of lipid-modifying therapy (LMT) for the treatment of abnormal levels of low-density lipoprotein cholesterol (LDL-C), triglycerides (TG) and high-density lipoprotein cholesterol (HDL-C) in Australian clinical practice.

Objective: To estimate the prevalence of MD in Australian patients undergoing LMT.

Methods: Patients 35 years of age and older undergoing LMT for ≥1 year were enrolled from nine general practice and cardiologist/endocrinologist outpatient clinics in Australia between April 2007 and May 2008. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3716499PMC
December 2013
6 Reads

Combined circumferential and longitudinal left ventricular systolic dysfunction in patients with type 2 diabetes mellitus without myocardial ischemia.

Exp Clin Cardiol 2013 ;18(1):e26-31

Department of Cardiology, Villa Bianca Hospital, Trento;

Background/objective: Left ventricular (LV) circumferential or longitudinal shortening may be impaired in patients with type 2 diabetes mellitus (DM). In the present study, patients with type 2 DM without myocardial ischemia and combined impairment of circumferential and longitudinal (C+L) shortening were studied to assess the prevalence and factors associated with this condition.

Methods: Data from 386 patients with type 2 DM enrolled in the SHORTening of midWall and longitudinAl left Ventricular fibers in diabEtes study were analyzed. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3716498PMC
December 2013
9 Reads

How do cardiorespiratory fitness improvements vary with physical training modality in heart failure patients? A quantitative guide.

Authors:
Neil A Smart

Exp Clin Cardiol 2013 ;18(1):e21-5

University of New England, School of Science and Technology, Armidale, New South Wales, Australia.

Background: Peak oxygen consumption (VO2) is the gold standard measure of cardiorespiratory fitness and a reliable predictor of survival in chronic heart failure patients. Furthermore, any form of physical training usually improves cardiorespiratory fitness, although the magnitude of improvement in peak VO2 may vary across different training prescriptions.

Objective: To quantify, and subsequently rank, the magnitude of improvement in peak VO2 for different physical training prescriptions using data from published meta-analyses and randomized controlled trials. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3716497PMC
December 2013
4 Reads

High prevalence of subclinical thyroid dysfunction and the relationship between thyrotropin levels and cardiovascular risk factors in residents of the coastal area of China.

Exp Clin Cardiol 2013 ;18(1):e16-20

Department of Cardiology, Binzhou Medical College, Yantai, China;

Objectives: To investigate the prevalence of subclinical thyroid dysfunction and the relationship between thyrotropin levels and cardiovascular risk factors in residents of the coastal area of China.

Methods: Atotalof4256individuals(mean[±SD]age50.51±14. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3716495PMC
December 2013
8 Reads

Hematological parameters and coronary collateral circulation in patients with stable coronary artery disease.

Exp Clin Cardiol 2013 ;18(1):e12-5

Abant Izzet Baysal University School of Medicine, Department of Cardiology, Bolu, Turkey.

Background: Although hematological parameters have been associated with prognosis in patients with various cardiovascular diseases, their relationship with coronary collateral (CC) circulation in patients with stable coronary artery disease (CAD) is unknown.

Objective: To investigate the relationship between hematological parameters and CC vessel development in patients with stable CAD.

Methods: A total of 96 patients who underwent coronary angiography were retrospectively enrolled. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3716494PMC
December 2013
11 Reads

Left ventricular systolic and diastolic function in subjects with a bicuspid aortic valve without significant valvular dysfunction.

Authors:
Mehmet Demir

Exp Clin Cardiol 2013 ;18(1):e1-4

Cardiology Department, Bursa Yüksek htisas Education and Research Hospital, Bursa, Turkey.

Background: The bicuspid aortic valve (BAV) represents the most common cardiac congenital malformation in adults. It is frequently associated with dilation, aneurysm and dissection of the ascending aorta.

Objective: To evaluate left ventricular systolic and diastolic function in subjects with BAVs. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3716490PMC
December 2013
10 Reads

Role of gamma-glutamyltransferase in cardiovascular diseases.

Exp Clin Cardiol 2013 ;18(1):53-6

Department of Cardiology, the Third Affiliated Hospital to Nantong University, Wuxi, Jiangsu Province, China.

Cardiovascular diseases are threatening human health with rising morbidity and mortality rates. Gamma-glutamyltransferase (GGT) has been found to be involved in the pathogenesis of cardiovascular diseases, especially coronary artery disease, and the prognosis of cardiovascular disease may be predicted by increasing GGT levels. GGT levels are related to cardiovascular emergencies of chronic heart failure, and an elevated GGT level has been shown to be an independent predictive maker for cardiac death and cardiac transplantation. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3716505PMC
December 2013
5 Reads

A novel measurement technique for the design of fenestrated stent grafts: Comparison with three-dimensional aorta models.

Exp Clin Cardiol 2013 ;18(1):48-52

Seoul Veterans Hospital, Seoul;

Background: Stent graft placement is an acceptable treatment option for aortic disease, particularly for abdominal aortic aneurysm. At present, the use of stent grafts is expanding beyond current indications for use. Fenestrated stent grafts are used in patients with abdominal aortic aneurysms whose aortic anatomy is unsuitable for repair using standard devices. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3716489PMC
December 2013
7 Reads

Validation of the vitronectin knockout mouse as a model for studying myocardial infarction: Vitronectin appears to influence left ventricular remodelling following myocardial infarction.

Exp Clin Cardiol 2013 ;18(1):43-7

Department of Pathology and Laboratory Medicine, University of British Columbia and the James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul's Hospital, Vancouver, British Columbia.

Background: Vitronectin (VN) is an abundant acute-phase plasma protein that regulates cell adhesion and migration as well as interactions with components of the plasminogen activator/plasmin system, specifically plasminogen activator inhibitor type 1. This system plays a major role in tissue remodelling regulating wound healing after myocardial infarction.

Objectives: To investigate the feasibility of using VN knockout mice (VN(-/-)) to study the role of VN on ventricular remodelling following myocardial infarction. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3716488PMC
December 2013
10 Reads

Effect of the stellate ganglion on atrial fibrillation and atrial electrophysiological properties and its left-right asymmetry in a canine model.

Exp Clin Cardiol 2013 ;18(1):38-42

Department of Arrhythmia, Cardiovascular Center, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China;

Objective: To investigate the effect of the stellate ganglion (SG) and its left-right asymmetry on atrial fibrillation (AF) inducibility, AF duration and atrial electrophysiological properties.

Methods: Sixteen adult mongrel dogs were randomly assigned to three groups. The control group (n=4) underwent 6 h rapid atrial pacing (RAP) only; the right SG (RSG) group (n=6) underwent 6 h RSG stimulation plus RAP; and the left SG (LSG) group (n=6) underwent 6 h LSG stimulation plus RAP. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3716487PMC
December 2013
10 Reads

Pacemaker-mediated angina.

Exp Clin Cardiol 2013 ;18(1):35-7

Department of Cardiology, University of South Alabama, Mobile, Alabama, USA.

Angina is a clinical syndrome characterized by discomfort in the chest, jaw, shoulder, back or arm. It is typically aggravated by exertion or emotional stress and relieved by nitroglycerin. Atherosclerotic coronary artery disease is the most common cause of angina. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3716486PMC
December 2013
11 Reads

Cardioverter-defibrillator implantation in myeloma-associated cardiac amyloidosis.

Exp Clin Cardiol 2013 ;18(1):31-4

Department of Cardiology, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan; ; Department of Cardiology, Cliniche Humanitas Gavazzeni, Bergamo;

A 62-year-old woman with multiple myeloma and light-chain amyloidosis with significant heart involvement developed an in-hospital cardiac arrest. After cardiopulmonary resuscitation, a stable sinus rhythm without any cerebral damage was restored, and the patient was admitted to the coronary care unit. A cardioverter-defibrillator was implanted, and it successfully intervened in two sustained ventricular tachycardia episodes and one ventricular fibrillation episode, which were recorded during hospitalization. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3716485PMC
December 2013
7 Reads

Right ventricular myocardial infarction: From pathophysiology to prognosis.

Exp Clin Cardiol 2013 ;18(1):27-30

Department of Internal Medicine and Cardiology, Masaryk University and University Hospital Brno, Brno, Czech Republic.

Right ventricle myocardial infarctions (RVMIs) accompany inferior wall ischemia in up to one-half of cases. The clinical sequelae of RVMIs vary from no hemodynamic compromise to severe hypotension and cardiogenic shock. Diagnosis is based on physical examination, electrocardiography, echocardiography and coronary angiography. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3716484PMC
December 2013
11 Reads

Mitral valve repair versus replacement in simultaneous aortic and mitral valve surgery.

Exp Clin Cardiol 2013 ;18(1):22-6

Department of Cardiovascular Surgery, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.

Background: Double valve replacement for concomitant aortic and mitral valve disease is associated with substantial morbidity and mortality. Excellent results with valve repair in isolated mitral valve lesions have been reported; therefore, whether its potential benefits would translate into better outcomes in patients with combined mitral-aortic disease was investigated.

Methods: A retrospective observational study was performed involving 341 patients who underwent aortic valve replacement with either mitral valve repair (n=42) or double valve replacement (n=299). Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3716483PMC
December 2013
6 Reads
1 Citation
0.760 Impact Factor

Percutaneous coronary intervention delays pacemaker implantation in coronary artery disease patients with established bradyarrhythmias.

Exp Clin Cardiol 2013 ;18(1):17-21

Department of Cardiology, The Fourth Clinical Hospital of Harbin Medical University, Harbin, China.

Background: Pacemakers have long been used to assist the heart under pathological conditions, and they are the first choice in the treatment of systematic bradyarrhythmias. However, the effect of percutaneous coronary intervention (PCI) in patients with coronary artery disease as well as bradyarrhythmias remains unknown.

Methods: In the present study, 42 patients with chest pain and/or abnormal stress test results were surveyed. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3716496PMC
December 2013
7 Reads

Effect of prostaglandin E1 inhalation on pulmonary hypertension following corrective surgery for congenital heart disease.

Exp Clin Cardiol 2013 ;18(1):13-6

Department of Cardiac Surgery, Charles Sturt University, Wagga Wagga, New South Wales, Australia;

Background: Intravenous infusion of prostaglandin E1 (PGE1) has been used to treat pulmonary arterial hypertension (PAH); however, the efficacy and safety of inhaled PGE1 is unclear.

Objectives: To investigate the effect of inhaled PGE1 on PAH following corrective surgery for congenital heart disease.

Methods: Sixty patients with postoperative residual PAH following corrective surgery for congenital heart disease were randomly assigned to a control group, a PGE1 infusion group (intravenous PGE1 infusion; 30 ng/kg/min daily for 10 days) or a PGE1 inhalation group (100 μg nebulized PGE1 every 8 h for 10 days). Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3716482PMC
December 2013
5 Reads

Depression increases the risk for uncontrolled hypertension.

Exp Clin Cardiol 2013 ;18(1):10-2

Metabolic and Research Clinic, Hospital General de Ticomán SS DF and Mexican Group for Basic and Clinical Research in Internal Medicine, México DF, México.

Background: Because hypertension and depression share common pathways, it is possible that each disease has an impact on the natural history of the other.

Objective: To determinate whether depression influences blood pressure control in hypertensive patients.

Methods: Forty hypertensive patients undergoing antihypertensive treatment, excluding beta-blockers and central-acting agents, self-measured their blood pressure several times a day for three days using a validated, commercially available device. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3716493PMC
December 2013
7 Reads

Ischemic postconditioning decreases matrix metalloproteinase-2 expression during ischemia-reperfusion of myocardium in a rabbit model: A preliminary report.

Exp Clin Cardiol 2013 ;18(2):e99-e101

Department of Cardiology, Liaocheng People's Hospital of Shandong University, Liaocheng, Shandong, Peoples' Republic of China;

Objective: To investigate the effect of ischemic postconditioning on the expression of matrix metalloproteinase (MMP)-2 during ischemia-reperfusion of myocardium in a rabbit model.

Methods: Thirty-six male New Zealand white rabbits were randomly divided into sham, ischemia-reperfusion and ischemic postconditioning groups. Myocardial ischemia-reperfusion was created by ligating the left anterior descending coronary artery for 30 min followed by 3 h of reperfusion. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3718608PMC
August 2013
9 Reads

Effects of low-dose hydroxychloroquine on expression of phosphorylated Akt and p53 proteins and cardiomyocyte apoptosis in peri-infarct myocardium in rats.

Exp Clin Cardiol 2013 ;18(2):e95-8

Division of Cardiology, Department of Geriatrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China ; Laboratory Research Center, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China.

Background: Low-dose hydroxychloroquine (HCQ) and ataxia-telangiectasia-mutated (ATM) protein kinase have recently been postulated to be beneficial for the prevention of the age-associated metabolic syndrome including hypertension, hypercholesterolemia and glucose intolerance; however, the effects of low-dose HCQ on the expression of ATM downstream phosphorylated Akt (protein kinase B) and p53 proteins and cardiomyocyte apoptosis in the peri-infarct myocardium remain unclear.

Objective: To explore the effects of low-dose HCQ on the expression of phosphorylated Akt and p53 proteins and cardiomyocyte apoptosis in the peri-infarct myocardium in a rat model.

Methods: Myocardial infarction (MI) was induced experimentally in a subset of rats, while others underwent sham operation (sham). Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3718607PMC
August 2013
9 Reads

Exercise-induced ST-segment elevation during the recovery phase of an exercise stress test.

Exp Clin Cardiol 2013 ;18(2):e92-4

Department of Electrophysiology, Division of Cardiology, University of Florida in Jacksonville, Jacksonville, Florida;

To the authors' knowledge, the present report represents the first case in the medical literature in which an ST-segment elevation during the recovery phase of an exercise stress test indicated significant left main coronary artery stenosis. Although the patient did not complain of chest pain during the test, the ST-segment elevation persisted 20 min into recovery. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3718606PMC
August 2013
5 Reads

Oxidative stress: Predictive marker for coronary artery disease.

Exp Clin Cardiol 2013 ;18(2):e88-91

Third Medical Faculty of Charles University and University Hospital Royal Vineyards, Prague, Czech Republic.

The role of oxidative stress in cardiovascular disease processes, such as atherogenesis, ischemic-reperfusion injury and cardiac remodelling, has been increasingly recognized in the past few decades. Currently, an increasing number of studies suggest that levels of oxidative stress markers in body fluids correlate with atherosclerotic disease activity. This finding may lead to novel clinical approaches in patients with coronary artery disease. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3718605PMC
August 2013
5 Reads

Nitrate-induced paradoxical ischemia predicts adverse outcomes in elderly patients with healed myocardial infarcts.

Exp Clin Cardiol 2013 ;18(2):e82-7

Nuclear Cardiology Service, Università Campus - Bio Medico di Roma, Via Alvaro del Portillo, Rome, Italy.

Background: It is well known that nitrates can induce paradoxical myocardial ischemia.

Methods And Results: Fifty patients (median age 73 years; range 67 to 78 years; 80% male) with healed myocardial infarcts were selected. All patients underwent resting single-photon emission computed tomography (SPECT) and resting baseline gated-SPECT using sestamibi or thallium-201 after the sublingual administration of 5 mg isosorbide dinitrate (ISD). Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3718604PMC
August 2013
9 Reads

Predictors of preinterventional patency of infarct-related artery in patients with ST-segment elevation myocardial infarction: Importance of neutrophil to lymphocyte ratio and uric acid level.

Exp Clin Cardiol 2013 ;18(2):e77-81

Adana Numune Education and Research Hospital, Department of Cardiology, Adana;

Background: Patients with ST-segment elevation myocardial infarction (STEMI) and a patent infarct-related artery (IRA) experience lower mortality and better clinical outcome, but little is known about the predictors of IRA patency before primary percutaneous coronary intervention (PCI) in the setting of STEMI.

Objective: To assess possible predictors of patency of IRA before primary PCI in patients with STEMI.

Methods: A total of 880 patients with STEMI undergoing primary PCI were prospectively included (646 male, 234 female; mean [± SD] age 58. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3718603PMC
August 2013
17 Reads

Correlation between major adverse cardiac events and coronary plaque characteristics.

Exp Clin Cardiol 2013 ;18(2):e71-6

Department of Cardiology, Chinese PLA General Hospital, Beijing, China.

Background: Unstable plaque is believed to be responsible for major adverse cardiac events (MACE).

Objective: To determine whether coronary computed tomography angiography (CCTA) could be used to predict future MACE.

Methods: Patients undergoing CCTA between January 2008 and February 2010 were consecutively enrolled in the study. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3718602PMC
August 2013
18 Reads

Functions of cyclophilin A in atherosclerosis.

Exp Clin Cardiol 2013 ;18(2):e118-24

Department of Cardiology, No.3 People's Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Cyclophilin A (CypA) is a ubiquitously distributed protein present both in intracellular and extracellular spaces. In atherosclerosis, various cells, including endothelial cells, monocytes, vascular smooth muscle cells and platelets, secrete CypA in response to excessive levels of reactive oxygen species. Atherosclerosis, a complicated disease, is the result of the interplay of different risk factors. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3718612PMC
August 2013
5 Reads

A modified murine model for the study of reverse cardiac remodelling.

Exp Clin Cardiol 2013 ;18(2):e115-7

Division of Cardiothoracic Surgery, University of Utah, Salt Lake City, Utah, USA.

Background: The authors previously reported a murine model of left ventricular hypertrophy (LVH) and regression using a suture technique of transverse aortic arch constriction and subsequent removal. A number of issues have limited the widespread adoption of this method. The present study assessed a modification of this model using a titanium clip. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3718611PMC
August 2013
9 Reads
5 Citations
0.760 Impact Factor

The effect of trans-resveratrol on platelet-neutrophil complex formation and neutrophil burst in hypercholesterolemic rats.

Exp Clin Cardiol 2013 ;18(2):e111-4

Department of Biochemistry, Faculty of Medicine, Bozok University, Antalya, Turkey.

Transresveratrol (t-resveratrol; 3,5,4'-trihydroxy-trans-stilbene) is a polyphenolic compound found in fresh grapes, grape juice and wine, and has been found to reduce the total cholesterol level in hypercholesterolemic rats. The objective of the present study was to assess the effects of t-resveratrol on platelet-neutrophil complex formation and neutrophil reactive oxygen species (ROS) status in control and hypercholesterolemic rats using a modified flow cytometric method. Rats (n=80) were divided into five groups (control, ethanol, resveratrol, hypercholesterolemic and resveratrol-administered hypercholesterolemic groups), comprising 16 animals per group. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3718610PMC
August 2013
11 Reads

The effects of cyclooxygenase and nitric oxide synthase inhibition on cardiodynamic parameters and coronary flow in isolated rat hearts.

Exp Clin Cardiol 2013 ;18(2):e102-10

Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia;

Background: Despite the widespread clinical use of cyclooxygenase (COX) inhibitors, dilemmas regarding the potential impact of these drugs on the cardiovascular system persist.

Objective: To estimate the effects of different COX inhibitors (meloxicam, acetylsalicylic acid [ASA] and SC-560) on cardiac function and coronary flow in isolated rat hearts, with special focus on the L-arginine/nitric oxide system.

Methods: The hearts of eight-week-old male Wistar albino rats (n=72; 12 rats per group; body mass 180 g to 200 g) were retrogradely perfused according to the Langendorff technique at gradually increased perfusion pressure (40 cmH2O to 120 cmH2O). Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3718609PMC
August 2013
11 Reads
1 Citation
0.760 Impact Factor

Effectiveness of a new inflatable balloon device for gluing dissected layers in an experimental model of aortic dissection.

Exp Clin Cardiol 2013 ;18(2):166-8

Department of Cardiovasculary Surgery, School of Medicine, Fatih University, Ankara;

Objectives: In the surgical treatment of acute aortic dissection, tissue glues are widely used to reinforce the adhesion between the dissected aortic layers. A new inflatable balloon device was developed to compress the dissected aortic wall during gluing to increase adhesion between the dissected layers. The present study used an ex vivo experimental animal model to test the hypothesis that this device is effective when gluing the true and false channels of dissected aortas. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3718600PMC
August 2013
6 Reads
1 Citation
0.760 Impact Factor

Effect of metoprolol on myocardial apoptosis and caspase-9 activation after coronary microembolization in rats.

Exp Clin Cardiol 2013 ;18(2):161-5

Department of Cardiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.

Objective: To explore the effect of metoprolol on myocardial apoptosis and caspase-9 activation after coronary microembolization (CME) in rats.

Methods: Forty rats were randomly divided into four groups (n=10 each): a sham operation (control) group, CME plus saline (CME) group, CME plus metoprolol (metoprolol) group and caspase-9 inhibitor Z-LEHD-FMK (ZLF) group. CME was induced by injecting 3000 polyethylene microspheres (42 μm diameter) into the left ventricle during a 10 s occlusion of the ascending aorta. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3718599PMC
August 2013
7 Reads

Substrate-dependent modulation of oxidative phosphorylation in isolated mitochondria following in vitro hypoxia and reoxygenation injury.

Exp Clin Cardiol 2013 ;18(2):158-60

Department of Anesthesiology, Sapporo Medical University School of Medicine, Sapporo, Japan.

Background/objectives: Previous studies using isolated mitochondria have provided new insight into the mechanisms and interventions for ischemia and reperfusion (I/R) injury. In in vitro experiments involving isolated mitochondria, hypoxia and reoxygenation (H/R) has been widely used to mimic I/R injury. However, in in vitro H/R mitochondrial experiments, the effects of various substrates on mitochondrial oxidative phosphorylation are unclear. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3718598PMC
August 2013
7 Reads

Wenxin Keli suppresses atrial substrate remodelling after epicardial ganglionic plexi ablation.

Exp Clin Cardiol 2013 ;18(2):153-7

Cardiovascular Research Institute of Wuhan Unviersity, Renmin Hospital of Wuhan University, China.

Background: The chronic effects of ganglionic plexi (GP) ablation on atrial fibrillation (AF) inducibility have not been elucidated.

Objective: To investigate the effect of Wenxin Keli (WK) on the inducibility of AF and atrial substrate remodelling after epicardial GP ablation.

Methods: Twenty dogs were randomly divided into a sham-operated group, a GP ablation group and a WK-treated group. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3718597PMC
August 2013
14 Reads

Chronic diarrhea as the initial clinical manifestation of light-chain amyloidosis with cardiac involvement despite negative duodenal and rectal biopsies.

Exp Clin Cardiol 2013 ;18(2):148-50

University of Technology Dresden, Department of Internal Medicine and Cardiology, Heart Center Dresden, University Hospital, Dresden, Germany.

Early and accurate diagnosis and a prompt initiation of treatment are critical for the prognosis of light-chain amyloidosis. The present article describes a case involving a 62-year-old patient who experienced unexplained, chronic diarrhea with negative duodenal and rectal biopsies. Serum immunofixation, a free light-chain assay, electrocardiography and echocardiography were performed after the patient developed syncope. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3718595PMC
August 2013
12 Reads

Pulmonary embolism, part II: Management.

Exp Clin Cardiol 2013 ;18(2):139-47

2nd Department of Medicine, Department of Cardiovascular Medicine, General University Hospital and 1st Faculty of Medicine, Charles University in Prague, Prague, Czech Republic.

Acute pulmonary embolism (PE) bears a significant burden on health and survival. Rapid and accurate risk stratification and management are of paramount importance to ensure the highest quality of care. This present article summarizes currently available and emerging management strategies for the disease. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3718594PMC
August 2013
4 Reads

Pulmonary embolism, part I: Epidemiology, risk factors and risk stratification, pathophysiology, clinical presentation, diagnosis and nonthrombotic pulmonary embolism.

Exp Clin Cardiol 2013 ;18(2):129-38

2nd Department of Medicine - Department of Cardiovascular Medicine, General University Hospital and 1st Faculty of Medicine, Charles University in Prague, Prague, Czech Republic.

Pulmonary embolism is an important clinical entity with considerable mortality despite advances in diagnosis and treatment. In the present article, the authors offer a comprehensive review focused mainly on epidemiology, risk factors, risk stratification, pathophysiological considerations and clinical presentation. Diagnosis based on assessment of clinical likelihood, electrocardiography, chest x-ray, D-dimer levels, markers of myocardial injury and overload, and blood gases is discussed in detail. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3718593PMC
August 2013
19 Reads

High-sensitivity C-reactive protein levels and treadmill exercise test responses in men and women without overt heart disease.

Exp Clin Cardiol 2013 ;18(2):124-8

Heart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil.

Background: C-reactive protein (CRP) is a marker of systemic inflammatory activity and may be modulated by physical fitness. Treadmill exercise testing is used to evaluate cardiovascular health through different variables including exercise capacity, heart rate and blood pressure responses. It was hypothesized that CRP levels are associated with these variables in men and women without overt heart disease. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3718592PMC
August 2013
12 Reads

The primary anomalies of coronary artery origin and course: A coronary angiographic analysis of 16,573 patients.

Exp Clin Cardiol 2013 ;18(2):121-3

Ondokuz Mayis University, Faculty of Medicine, Cardiology Department, Samsun, Turkey.

Background/objectives: Coronary artery anomalies are present at birth, but relatively few are symptomatic. The majority are discovered incidentally. In the present study, coronary angiograms performed in the authors' centre (Ondokuz Mayis University Hospital, Samsun, Turkey) were analyzed to determine the prevalence and types of coronary artery origin and course anomalies. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3718591PMC
August 2013
13 Reads