5,040 results match your criteria Experimental Gerontology[Journal]


Continuous intracerebroventricular injection of Porphyromonas gingivalis lipopolysaccharide induces systemic organ dysfunction in a mouse model of Alzheimer's disease.

Exp Gerontol 2019 Feb 17. Epub 2019 Feb 17.

Department of Pharmacology and Molecular Therapeutics, Graduate School of Medical Sciences, Kumamoto University, Japan.

Systemic organ dysfunction is one of the important issues for the patients with Alzheimer's disease (AD) and their caregivers. Recent evidences suggest that periodontitis is a possible risk factor for progression of AD and lipopolysaccharide derived from Porphyromonas gingivalis (Pg-LPS) which is a major periodontopathic bacteria induces cognitive impairment in mice. However, the precise relationships between the brain exposure of Pg-LPS and systemic organ dysfunction in AD patients are still undetermined. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.exger.2019.02.007DOI Listing
February 2019

Long-term stimulation of angiotensin II induced endothelial senescence and dysfunction.

Exp Gerontol 2019 Feb 15. Epub 2019 Feb 15.

State Key Laboratory of Cardiovascular Disease, FuWai Hospital, National Center for Cardiovascular Diseases, Peking Union Medical College, Chinese Academy of Medical Sciences, Beilishi Road 167, Xicheng District, Beijing 100037, China. Electronic address:

The role of angiotensin II (Ang II) in hypertension has been clarified, but recent studies show that aging-associated arterial changes and those with hypertension as well as atherosclerosis may have some common pathogenesis. This study aimed to clarify the effects of Ang II on endothelial senescence by establishing a replicative senescence model of human umbilical vein endothelial cells (HUVECs) in vitro. The population-doubling level (PDL) was calculated, PDL5 and PDL25 respectively referred to cells cultured for 2 days and 30 days. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S05315565183049
Publisher Site
http://dx.doi.org/10.1016/j.exger.2019.02.012DOI Listing
February 2019
2 Reads

HSF1/HSP pathway in the hippocampus is involved in SIRT1-mediated caloric restriction-induced neuroprotection after surgery in aged mice.

Exp Gerontol 2019 Feb 14;119:184-192. Epub 2019 Feb 14.

Department of Anesthesia, Zhongshan Hospital, Fudan University, Shanghai 200032, China. Electronic address:

Postoperative cognitive dysfunction is common in the elderly. Endoplasmic reticulum stress (ER-stress) increases neuronal apoptosis after surgery, and chaperone molecules, such as heat shock proteins (HSPs), help reduce unfolded protein reactions, thereby promoting protein homeostasis. Mammal sirtuin1 (SIRT1)-mediated deacetylation of heat shock factor 1 (HSF1) upregulates HSF1 binding to the HSP70 promoter. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.exger.2019.02.011DOI Listing
February 2019

Objective physical activity and physical performance in middle-aged and older adults.

Exp Gerontol 2019 Feb 13. Epub 2019 Feb 13.

Framingham Heart Study, Framingham, MA, USA; Department of General Internal Medicine, Boston University School of Medicine, Boston, MA, USA.

Background: Older adults may have difficulty meeting the Physical Activity (PA) Guidelines. A favorable balance between PA and sedentary time (SED) is an important determinant of physical performance in older adults. Our objective was to explore associations of PA/SED with physical performance across mid-older age in adults without overt mobility disability. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.exger.2019.02.003DOI Listing
February 2019
1 Read

Activity and intracellular localization of senescence-associated β-galactosidase in aging Xenopus oocytes and eggs.

Exp Gerontol 2019 Feb 12;119:157-167. Epub 2019 Feb 12.

Department of Molecular Biosciences, Kyoto Sangyo University, Kamigamo-motoyama, Kita-ku, Kyoto 603-8555, Japan. Electronic address:

Senescence-associated β-galactosidase (SA-β-gal) serves as a marker of senescence in aging somatic cells. However, little is known about SA-β-gal dynamics in aging gamete cells. To address this issue, here we investigated activity and intracellular localization of SA-β-gal in freshly obtained and aging oocytes and eggs of the African clawed frog Xenopus laevis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.exger.2019.02.002DOI Listing
February 2019

The impact of age on cardiac function and extracellular matrix component expression in adverse post-infarction remodeling in mice.

Exp Gerontol 2019 Feb 11. Epub 2019 Feb 11.

Ludwig Boltzmann Cluster for Cardiovascular Research at the Center for Biomedical Research, Medical University of Vienna, Waehringer Guertel 18-20, Leitstelle 1Q, 1090 Wien, Austria; Department of Cardiac Surgery, University Hospital St. Poelten, Dunant-Platz 1, 3100 St. Poelten, Austria. Electronic address:

The aim of this study was to describe the potential associations of the expression of matricellular components in adverse post-infarction remodeling of the geriatric heart. In male geriatric (OM, age: 18 months) and young (YM, age: 11 weeks) OF1 mice myocardial infarction (MI) was induced by permanent ligation of the left anterior descending coronary artery. Cardiac function was evaluated by MRI. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.exger.2019.02.008DOI Listing
February 2019

Immunosenescence in honey bees (Apis mellifera L.) is caused by intrinsic senescence and behavioral physiology.

Exp Gerontol 2019 Feb 8;119:174-183. Epub 2019 Feb 8.

Departamento de Biologia, Faculdade de Filosofia Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil.

Young honey bee workers (0 to 2-3 weeks old) perform tasks inside the colony, including brood care (nursing), whereas older workers undergo foraging tasks during the next 3-4 weeks, when an intrinsic senescence program culminates in worker death. We hypothesized that foragers are less able to react to immune system stimulation than nurse bees and that this difference is due to an inefficient immune response in foragers. To test this hypothesis, we used an experimental design that allowed us to uncouple chronological age and behavior status (nursing/foraging). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.exger.2019.02.005DOI Listing
February 2019

Potassium restriction boosts vacuolar acidity and extends lifespan in yeast.

Exp Gerontol 2019 Feb 8. Epub 2019 Feb 8.

Buck Institute for Research on Aging, Novato, CA, United States of America; Department of Plant and Microbial Biology, UC Berkeley, Berkeley, CA, United States of America. Electronic address:

Lysosome function is compromised during aging and in many disease states. Interventions that promote lysosomal activity and acidification are thus of prime interest as treatments for longevity and health. Intracellular pH can be controlled by the exchange of protons for inorganic ions, and in cells from microbes to man, when potassium is restricted in the growth medium, the cytoplasm becomes acidified. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.exger.2019.02.001DOI Listing
February 2019

Sex-specific stress tolerance, proteolysis, and lifespan in the invertebrate Tigriopus californicus.

Exp Gerontol 2019 Feb 7;119:146-156. Epub 2019 Feb 7.

Department of Biological Sciences, Wrigley Institute for Environmental Studies, University of Southern California, Los Angeles, CA 90089, USA. Electronic address:

Because stress tolerance and longevity are mechanistically and phenotypically linked, the sex with higher acute stress tolerance might be expected to also live longer. On the other hand, the association between stress tolerance and lifespan may be complicated by tradeoffs between acute tolerance and long-term survival. Here we use the copepod Tigriopus californicus to test for sex differences in stress resistance, proteolytic activity and longevity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.exger.2019.02.006DOI Listing
February 2019
1 Read

Diabetic neuropathies influence recovery from hip-fracture surgery in older persons with diabetes.

Exp Gerontol 2019 Feb 7;119:168-173. Epub 2019 Feb 7.

Healthy Aging Research Center, Chang Gung University, 259 Wenhua 1st Road, Guishan District, Taoyuan 33302, Taiwan; School of Nursing, College of Medicine, Chang Gung University, 259 Wenhua 1st Road, Guishan District, Taoyuan 33302, Taiwan; Department of Orthopedic Surgery, Linkou Chang Gung Memorial Hospital, 5 Fuxing Street, Guishan District, Taoyuan 33305, Taiwan; Department of Nursing, Kaohsiung Chang Gung Memorial Hospital, 123 Dapi Road, Niaosng District, Kaohsiung 83301, Taiwan; Department of Gerontology and Health Care Management, Chang Gung University of Science and Technology, 261 Wenhwa 1st Road, Guishan District, Taoyuan 33303, Taiwan. Electronic address:

Background/objectives: To explore the impact of diabetic peripheral neuropathy (DPN) on the recovery of older persons with diabetes mellitus (DM) after hip-fracture surgery.

Design, Setting, Participants: Secondary data for this study came from a clinical trial on the effectiveness of a DM-specific care model for 176 older persons (age ≥ 60) with DM over 2 years following hip-fracture surgery at a medical center in Taiwan. In the original trial, the experimental group (n = 88) received DM-specific care comprising diabetes care plus subacute care, and the control group (n = 88) received only usual care. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.exger.2019.02.004DOI Listing
February 2019
1 Read

Elite athletes have longer telomeres than sedentary subjects: A meta-analysis.

Exp Gerontol 2019 Feb 6;119:138-145. Epub 2019 Feb 6.

Universidade Federal do Pará - UFPA, Pós-Graduação em Genética e Biologia Molecular, Rua Augusto Corrêa 1, Belém 66075-110, PA, Brazil.

The aim of this meta-analysis was to investigate the effects of high levels of physical activity (in elite athletes) and sedentary lifestyle on telomere length. Our meta-analysis was carried out using the following electronic databases: PubMed, Cochrane Library, LILACS, Science Direct and EBSCO. After study selection, nine articles were included in our meta-analysis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.exger.2019.01.023DOI Listing
February 2019

Coupling lifespan and aging? The age at onset of body mass decline associates positively with sex-specific lifespan but negatively with environment-specific lifespan.

Exp Gerontol 2019 Jan 31;119:111-119. Epub 2019 Jan 31.

Groningen Institute for Evolutionary Life Sciences, University of Groningen, Groningen, the Netherlands.

Whether lifespan scales to age-associated changes in health and disease is an urgent question in societies with increasing lifespan. Body mass is associated with organismal functioning in many species, and often changes with age. We here tested in zebra finches whether two factors that decreased lifespan, sex and poor environmental quality, accelerated the onset of body mass declines. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.exger.2019.01.030DOI Listing
January 2019

Sarcopenia-related parameters in adults with Down syndrome: A cross-sectional exploratory study.

Exp Gerontol 2019 Jan 30;119:93-99. Epub 2019 Jan 30.

Fondazione Policlinico Universitario "Agostino Gemelli" IRCCS, Rome, Italy.

Background: People with Down syndrome (DS) experience premature aging. Whether this accelerated aging also involves early declines in muscle mass, strength and physical performance is presently unclear. The present study investigated the prevalence of sarcopenia parameters in adults with DS. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.exger.2019.01.028DOI Listing
January 2019
1 Read

Exogenous testosterone alleviates cardiac fibrosis and apoptosis via Gas6/Axl pathway in the senescent mice.

Exp Gerontol 2019 Jan 30;119:128-137. Epub 2019 Jan 30.

The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese Ministry of Health and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Department of Cardiology, Qilu Hospital of Shandong University, Jinan, China. Electronic address:

Background: Androgen has been implicated in aging-related cardiac remodeling, but its precise role in aging heart remains controversial. We aimed to investigate the role of testosterone in the development of aging-related cardiac remodeling and the mechanisms involved.

Methods: Wild type and Axl knockout mice (Axl) were randomized into three groups: the young group (n = 30, 3 months old), the aging group (n = 30, 18 months old), the testosterone undecanoate treatment group (TU, n = 30, 18 months old). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.exger.2019.01.029DOI Listing
January 2019
3.485 Impact Factor

Autophagy in Alzheimer's disease and promising modulatory effects of herbal medicine.

Exp Gerontol 2019 Jan 30;119:100-110. Epub 2019 Jan 30.

Integrated Chinese and Western Medicine postdoctoral research station, Jinan University, Guangzhou 510632, China; Shenzhen Institute of Geriatrics, Shenzhen 518020, China; The First Affiliated Hospital of Shenzhen University, Shenzhen 518035, China. Electronic address:

Alzheimer's disease (AD) is a progressive and unremitting neurodegenerative disorder characterized by memory loss and cognitive impairment. It affects the quality of life of victims severely. The prevalence of AD has been increasing in recent years. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.exger.2019.01.027DOI Listing
January 2019
1 Read

Effect of pre-exercise and post-exercise creatine supplementation on bone mineral content and density in healthy aging adults.

Exp Gerontol 2019 Jan 29;119:89-92. Epub 2019 Jan 29.

Faculty of Kinesiology and Health Studies, University of Regina, Regina, SK, Canada.

Creatine supplementation, immediately before and immediately following resistance training, has been shown to increase muscle mass and strength. However, the effects of pre- exercise and post-exercise creatine supplementation on aging bone mineral content (BMC) and density (BMD) is unknown. Using a double-blind, repeated measures design, aging adults were randomized to one of three groups: creatine before (CR-B: n = 15; 53 ± 3 years, 170. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.exger.2019.01.025DOI Listing
January 2019
3.485 Impact Factor

Cardioprotection by spermidine does not depend on structural characteristics of the myocardial microcirculation in aged mice.

Exp Gerontol 2019 Jan 28;119:82-88. Epub 2019 Jan 28.

Institute of Functional and Applied Anatomy, Hannover Medical School, 30625 Hannover, Germany; Cluster of Excellence REBIRTH (From Regenerative Biology to Reconstructive Therapy), Hannover, Germany; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Hannover, Germany. Electronic address:

Aims: Ageing is associated with cardiovascular disease and reduced cardiac function. This cardiac functional decline is accompanied by cardiac remodeling and alterations in cardiomyocyte composition. Recently, it was shown that the natural polyamine spermidine preserves cardiac function and cardiomyocyte composition in old mice. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.exger.2019.01.026DOI Listing
January 2019

Influence of aging and visual feedback on the stability of hand grip control in elderly adults.

Exp Gerontol 2019 Jan 26;119:74-81. Epub 2019 Jan 26.

Masters Program in Long-Term Care & School of Gerontology Health Management, College of Nursing, Taipei Medical University, 250 Wu-Xing Street, Taipei 110, Taiwan, ROC.

Aging causes a gradual decrease in maximal grip strength and leads many elderly people to have to rely on visual feedback to compensate for poorer muscle strength in performing daily activities and preventing accidents. Previous studies have investigated age and visual feedback-related changes in grip strength. However, little is known about methods of determining the quality and stability of hand grip strength control in the elderly, which is important for understanding their ability to generate grip force when handling objects with and without visual feedback in daily living. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.exger.2019.01.024DOI Listing
January 2019

Nrf2 deficiency exacerbates frailty and sarcopenia by impairing skeletal muscle mitochondrial biogenesis and dynamics in an age-dependent manner.

Exp Gerontol 2019 Jan 25;119:61-73. Epub 2019 Jan 25.

Department of Gastrointestinal Surgery, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China; Shanghai Tenth People's Hospital Chongming Branch Affiliated to Tongji University, Shanghai, China. Electronic address:

Aim: Mitochondrial dysfunction during aging is a key factor that contributes to sarcopenia. Nuclear factor erythroid 2-related factor 2 (Nrf2) has been increasingly recognized to regulate mitochondrial function. The present study aimed to investigate the role of Nrf2 in the development of frailty and sarcopenia during aging, and to demonstrate whether Nrf2 contributes to the maintenance of muscle mass and function by regulation of mitochondrial biogenesis and dynamics during the aging process. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.exger.2019.01.022DOI Listing
January 2019

Novel biomolecules of ageing, sex differences and potential underlying mechanisms of telomere shortening in coronary artery disease.

Exp Gerontol 2019 Jan 23;119:53-60. Epub 2019 Jan 23.

Center for Clinical Heart Research, Department of Cardiology, Oslo University Hospital, Ullevål, Norway; Center for Heart Failure Research, Oslo University Hospital, Norway; Faculty of Medicine, University of Oslo, Norway.

Telomere length (TL), growth differentiate factor (GDF)11, insulin growth factor (IGF)1, sirtuin (SIRT)1 and inflammatory processes have been related to ageing and age-related diseases, like coronary artery disease (CAD). We aimed to investigate the associations between leukocyte TLs (LTLs), chronological age, sex and comorbidities in CAD patients. Any covariations between LTL, GDF11, IGF1, SIRT-1 and pro-inflammatory cytokines were further assessed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.exger.2019.01.020DOI Listing
January 2019
3 Reads

Standardization of the Fried frailty phenotype improves cardiovascular disease risk discrimination.

Exp Gerontol 2019 Jan 23;119:40-44. Epub 2019 Jan 23.

Faculty of Kinesiology & Recreation Management, Health, Leisure & Human Performance Research Institute, University of Manitoba, Winnipeg, Manitoba, Canada; Institute of Cardiovascular Sciences, St. Boniface Hospital Albrechtsen Research Centre, Winnipeg, Manitoba, Canada. Electronic address:

Background: Standardizing the Fried criteria (S-FC) using cutoffs specific to the patient population improves adverse outcome prediction. However, there is limited evidence to determine if a S-FC assessment can improve discrimination of cardiovascular disease (CVD) risk in middle-aged and older women.

Design: The objective of this cross-sectional analysis was to compare the ability of the Fried frailty phenotype criteria (FC) to discriminate between individuals at higher risk for CVD according to the Framingham Risk Score and Rasmussen Disease Score in comparison to the S-FC. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S05315565183040
Publisher Site
http://dx.doi.org/10.1016/j.exger.2019.01.021DOI Listing
January 2019
4 Reads

Transcriptomic analysis of the life-extending effect exerted by black rice anthocyanin extract in D. melanogaster through regulation of aging pathways.

Exp Gerontol 2019 Jan 22;119:33-39. Epub 2019 Jan 22.

State Key Laboratory of Food Nutrition and Safety, Tianjin University of Science and Technology (TUST), Tianjin 300457, China. Electronic address:

This study examined the beneficial effects of black rice anthocyanin extract (BRAE), which provides as an excellent source of dietary antioxidants, on the lifespan of fruit flies and the underlying molecular mechanisms. Results showed that supplementation of BRAE extended the lifespan of fruit flies by 20% and retarded the loss of locomotor function. Comparison of mRNA transcriptome profile between fruit flies of 20 days and 50 days after the start of normal diet and normal diet supplemented with BRAE (5 mg/mL) identified 6687 differentially expressed coding genes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.exger.2019.01.015DOI Listing
January 2019
1 Read

Orthostatic blood pressure variability is associated with lower visual contrast sensitivity function: Findings from The Irish Longitudinal Study on Aging.

Exp Gerontol 2019 Jan 22;119:14-24. Epub 2019 Jan 22.

Department of Medical Gerontology, School of Medicine, Trinity College Dublin, The University of Dublin, Old Stone Building, Trinity Centre for Health Sciences, St James's Hospital, James's Street, Dublin 8, Ireland; The Irish Longitudinal Study on Aging (TILDA), Lincoln Gate, Trinity College Dublin, The University of Dublin, College Green, Dublin 2, Ireland. Electronic address:

Background: Hypertension is established to cause vascular end-organ damage. Other forms of dysregulated blood pressure (BP) behaviour, such as orthostatic hypotension have also been associated with cardiovascular (CV) events. The eye is potentially vulnerable to dysregulated systemic BP if ocular circulation autoregulation is impaired. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S05315565183022
Publisher Site
http://dx.doi.org/10.1016/j.exger.2019.01.009DOI Listing
January 2019
7 Reads

p38 MAPK-dependent alphaB-crystallin phosphorylation in Alzheimer's disease-like pathology in OXYS rats.

Exp Gerontol 2019 Jan 19;119:45-52. Epub 2019 Jan 19.

Institute of Cytology and Genetics, Novosibirsk, Russia.

Alzheimer's disease (AD) is an age-related neurodegenerative disorder. Development of AD is closely related to alterations of proteostasis including the deposition of amyloid beta (Aβ) and hyperphosphorylated tau in the brain. Molecular chaperones such as αB-crystallin (CryaB) can prevent aggregation of proteins and enable their correct refolding. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.exger.2019.01.017DOI Listing
January 2019
2 Reads

Injecting autologous platelet rich plasma solely into the knee joint is not adequate in treating geriatric patients with moderate to severe knee osteoarthritis.

Exp Gerontol 2019 Jan 19;119:1-6. Epub 2019 Jan 19.

Department of Physical Medicine & Rehabilitation, Chang Gung Memorial Hospital at Linkou and College of Medicine, Chang Gung University, Kwei-Shan, Tao-Yuan City, Taiwan.

Knee pain caused by osteoarthritis (OA) is commonly seen in geriatric patients. Patients with knee OA are often complicated with joint pain, soreness, and weakness. The injection of autologous platelet rich plasma (aPRP) has been proven to be effective in treating mild knee OA. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.exger.2019.01.018DOI Listing
January 2019
3 Reads

Adherence to the Mediterranean diet, dietary factors, and S-Klotho plasma levels in sedentary middle-aged adults.

Exp Gerontol 2019 Jan 17;119:25-32. Epub 2019 Jan 17.

Department of Medical Physiology, School of Medicine, University of Granada, Spain.

Introduction: The ageing process can be influenced by different dietary patterns and dietary factors.

Aim: To analyse the association of dietary factors, which include the Mediterranean diet adherence, the compliance with the "Sociedad Española de Nutrición Comunitaria" food portion recommendations, and the intake of different food groups, with the secreted form of the α-Klotho gene (S-Klotho as an anti-ageing marker) in middle-aged sedentary adults.

Methods: A total of 74 (39 women) middle-aged sedentary adults participated in the study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.exger.2019.01.019DOI Listing
January 2019
2 Reads

Osthole inhibits oleic acid/lipopolysaccharide-induced lipid accumulation and inflammatory response through activating PPARα signaling pathway in cultured hepatocytes.

Exp Gerontol 2019 Jan 16;119:7-13. Epub 2019 Jan 16.

Department of Pharmacology, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, College of Pharmaceutical Sciences, Soochow University, Suzhou 215123, Jiangsu Province, China. Electronic address:

Osthole, a coumarin derivative, can increase hepatic peroxisome proliferator-activated receptor α (PPARα) expression and reduce hepatic steatosis and inflammatory response in rats with non-alcoholic steatohepatitis (NASH). In this study, a cell model of NASH was induced with oleic acid (OA)/lipopolysaccharide (LPS) and treated for 36 h with different osthole concentrations. Results showed that intracellular lipid and inflammatory cytokine levels gradually decreased after osthole treatment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.exger.2019.01.014DOI Listing
January 2019
1 Read

Effects of aerobic fitness on cognitive performance as a function of dual-task demands in older adults.

Exp Gerontol 2019 Apr 16;118:99-105. Epub 2019 Jan 16.

Beckman Institute, University of Illinois at Urbana Champaign, 405 N Mathews Ave, Urbana, IL 61801, USA; Department of Kinesiology and Community Health, University of Illinois at Urbana Champaign, Freer Hall, 906 S Goodwin Ave, Urbana, IL 61801, USA.

The objective of this study was to examine the effects of aerobic fitness on cognitive performance under varying dual-task demands in older adults. Thirty-four participants (mean ± SD age: 68.6 ± 10. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.exger.2019.01.013DOI Listing
April 2019
1 Read

Budesonide, Aclidinium and Formoterol in combination limit inflammaging processes in bronchial epithelial cells exposed to cigarette smoke.

Exp Gerontol 2019 Apr 16;118:78-87. Epub 2019 Jan 16.

Istituto di Biomedicina e Immunologia Molecolare, Consiglio Nazionale delle Ricerche, Palermo, Italy. Electronic address:

Inflammation and cellular senescence (also called inflammaging) are involved in the pathogenesis of premature lung aging, a key driver of chronic obstructive pulmonary disease (COPD). Downregulation of histone deacetylases and FoxO3 expression, activation of the ERK 1/2 pathway and IL-8 increase are hallmarks of lung inflammaging. The effects of Budesonide (BUD), Aclidinium (ACL) and Formoterol (FO) on lung inflammaging are unknown. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.exger.2019.01.016DOI Listing
April 2019
2 Reads

A novel neurocognitive approach for placebo analgesia in neurocognitive disorders.

Exp Gerontol 2019 Apr 15;118:106-116. Epub 2019 Jan 15.

Department of Psychology, University of Turin, Italy; European Innovation Partnership on Active and Healthy Ageing, Brussels, Belgium.

Neural correlates of placebo analgesia (PA) in patients with neurocognitive disorders have not yet been elucidated. The present study aimed to evaluate how and to what extent executive (dys)functions of the medial prefrontal cortex (MPFC) may be related to PA. To this end, twenty-three subjects complaining of different cognitive deficits (from mild cognitive impairment likely due to Alzheimer's disease to mild AD) were recruited. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S05315565183008
Publisher Site
http://dx.doi.org/10.1016/j.exger.2019.01.011DOI Listing
April 2019
6 Reads

Changes in motor function and brain cortex mitochondrial active oxygen species production in aged mice.

Exp Gerontol 2019 Apr 15;118:88-98. Epub 2019 Jan 15.

Centro de Altos Estudios en Ciencias de la Salud, Universidad Abierta Interamericana, Buenos Aires, Argentina.

Neuronal ageing is a complex physiological process, associated to metabolic and motor changes. In this study, 3 and 17 months old male Swiss mice were used. Aged mice exhibited a significant reduction in motor performance and walking footprint pattern. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.exger.2019.01.012DOI Listing
April 2019
1 Read

Superoxide dismutase activity and risk of cognitive decline in older adults: Findings from the Chinese Longitudinal Healthy Longevity Survey.

Exp Gerontol 2019 Apr 14;118:72-77. Epub 2019 Jan 14.

School of Public Health, Capital Medical University, Beijing 100069, China; Beijing Municipal Key Laboratory of Clinical Epidemiology, Capital Medical University, Beijing 100069, China. Electronic address:

Background: The association between superoxide dismutase (SOD) activity and cognitive decline in older adults remains controversial.

Objectives: This study was designed to examine the association between plasma superoxide dismutase (SOD) activity and cognitive decline in older population.

Method: We analyzed the follow-up data from 2012 to 2014 waves of the Chinese Longitudinal Healthy Longevity Survey (CLHLS), a community-based longitudinal survey in Chinese longevity areas. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.exger.2019.01.010DOI Listing
April 2019
2 Reads

Prospective associations of low muscle mass and strength with health-related quality of life over 10-year in community-dwelling older adults.

Exp Gerontol 2019 Apr 12;118:65-71. Epub 2019 Jan 12.

Menzies Institute for Medical Research, University of Tasmania, Australia. Electronic address:

Aims: This study aims to describe the associations of low muscle mass, handgrip (HGS) and lower-limb muscle strength (LMS) with health-related quality of life (HRQoL) over 10 years in community-dwelling older adults.

Methods: Participants (N = 1002; 51% women; mean age 63 ± 7.4 years) were prospectively followed for 10 years. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.exger.2019.01.008DOI Listing
April 2019
1 Read

Prospective association of white matter hyperintensity volume and frailty in older adults.

Exp Gerontol 2019 Apr 10;118:51-54. Epub 2019 Jan 10.

Gérontopôle de Toulouse, Institut du Vieillissement, Centre Hospitalo-Universitaire de Toulouse, 37 allée Jules Guesdes, 31000 Toulouse, France; UMR INSERM, 1027 University of Toulouse III, Faculté de médecine, 37 allées Jules Guesde, 31000 Toulouse, France.

Background: Frailty is a prevalent geriatric condition and its association with brain health is still weakly investigated. The objective of this study was to examine whether brain white matter hyperintensities (WMH) were related to longitudinal changes in frailty severity in community-dwelling older adults.

Methods: 113 community-dwelling older adults, aged 70 years and over, enrolled in the placebo group from the 3-year Multidomain Alzheimer's Preventive Trial (MAPT). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.exger.2019.01.007DOI Listing
April 2019
1 Read

Trimetazidine and l‑carnitine prevent heart aging and cardiac metabolic impairment in rats via regulating cardiac metabolic substrates.

Exp Gerontol 2019 Jan 9;119:120-127. Epub 2019 Jan 9.

Department of Gerontology, Qilu Hospital, Shandong University, Jinan 250012, China. Electronic address:

Background: This study aimed to investigate the effects of trimetazidine and l‑carnitine on heart aging and cardiac metabolism in the natural aging rats and explore the possible mechanism regarding the regulation of cardiac metabolic substrates.

Methods: A total of 28 young (2-month-old) and 28 aged (14-month-old) male Sprague-Dawley rats were randomly allocated to the following groups: young control (YC, n = 8), young trimetazidine (YT, n = 10), young l‑carnitine (YL, n = 10), aging control (AC, n = 8), aging trimetazidine (AT, n = 10), and aging l‑carnitine (AL, n = 10). All rats were intragastrically treated with saline, trimetazidine, or l‑carnitine for 4 weeks. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.exger.2018.12.019DOI Listing
January 2019
1 Read

Age-related alterations in swallowing biomechanics.

Exp Gerontol 2019 Apr 8;118:45-50. Epub 2019 Jan 8.

Division of Otolaryngology-Head and Neck Cancer, Department of Surgery, University of Wisconsin School of Medicine and Public Health, United States of America; Department of Biomedical Engineering, University of Wisconsin-Madison, United States of America; Department of Communication Sciences and Disorders, University of Wisconsin-Madison, United States of America.

Background: Aging rodent models allow for the discovery of underlying mechanisms of cranial muscle dysfunction. Methods are needed to allow quantification of complex, multivariate biomechanical movements during swallowing. Videofluoroscopic swallow studies (VSS) are the standard of care in assessment of swallowing disorders in patients and validated quantitative, kinematic, and morphometric analysis methods have been developed. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S05315565183061
Publisher Site
http://dx.doi.org/10.1016/j.exger.2019.01.006DOI Listing
April 2019
7 Reads

Neural control of postural sway: Relationship to strength measures in young and elderly adults.

Exp Gerontol 2019 Apr 8;118:39-44. Epub 2019 Jan 8.

Bone-Muscle Collaborative Sciences, College of Nursing and Health Innovation, University of Texas, Arlington, TX, USA.

Age-related changes in postural sway are well-established, and studied from a control perspective using an inverted pendulum model. The purpose of the present work was to expand previous research in this area by investigating relationships between sway-related control parameters and musculoskeletal measures of muscle function and health. Eleven female older adults and eight female young adults completed blood draw, grip, leg extension, and balance tests. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S05315565183046
Publisher Site
http://dx.doi.org/10.1016/j.exger.2019.01.005DOI Listing
April 2019
3 Reads

Impact of aging and caloric restriction on fibroblast growth factor 21 signaling in rat white adipose tissue.

Exp Gerontol 2019 Apr 5;118:55-64. Epub 2019 Jan 5.

Laboratory of Molecular Pathology and Metabolic Disease, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, Japan; Translational Research Center, Research Institute of Science and Technology, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, Japan. Electronic address:

Caloric restriction (CR) suppresses age-related pathophysiology and extends lifespan. We recently reported that metabolic remodeling of white adipose tissue (WAT) plays an important role in the beneficial actions of CR; however, the detailed molecular mechanisms of this remodeling remain to be established. In the present study, we aimed to identify CR-induced alterations in the expression of fibroblast growth factor 21 (FGF21), a regulator of lipid and glucose metabolism, and of its downstream signaling mediators in liver and WAT, across the lifespan of rats. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.exger.2019.01.001DOI Listing
April 2019
3 Reads

Association between naturally occurring spine osteoarthritis in geriatric rats and neurogenic inflammation within neurosegmentally linked skeletal muscle.

Exp Gerontol 2019 Apr 4;118:31-38. Epub 2019 Jan 4.

Department of Human Health and Nutritional Science, University of Guelph, 50 Stone Road East, Guelph, ON N1G 2W1, Canada. Electronic address:

Objective: This study aimed to investigate the association between naturally occurring spinal osteoarthritis (OA) (L3-L5), the expression of substance P (SP) centrally (L4-L5) and the presence of neurogenic inflammation within the neurosegmentally linked quadriceps (L2-L5) in elderly rats versus young controls.

Design: Eight aged (27 ± 3.2 months) and six young (4 ± 0. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S05315565183056
Publisher Site
http://dx.doi.org/10.1016/j.exger.2019.01.002DOI Listing
April 2019
7 Reads

Effects of short-term resistance training on endothelial function and inflammation markers in elderly patients with type 2 diabetes: A randomized controlled trial.

Exp Gerontol 2019 Apr 3;118:19-25. Epub 2019 Jan 3.

Exercise Research Laboratory, School of Physical Education, Phisiotherapy and Dance, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS 90690-200, Brazil.

Purpose: To evaluate the effects of 12-weeks of strength training on endothelial function and inflammatory markers in elderly individuals with T2DM.

Methods: Forty-four elderly patients with T2DM were screened for participation. After completion of the baseline assessment, participants were randomly assigned to either the resistance training group (RT) or an active control group (AC). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.exger.2019.01.003DOI Listing
April 2019
2 Reads

Longitudinal association between brain volume change and gait speed in a general population.

Exp Gerontol 2019 Apr 4;118:26-30. Epub 2019 Jan 4.

Institute of Human Genomic Study, School of Medicine, Korea University Ansan Hospital, Ansan, Republic of Korea; Division of Pulmonary, Sleep and Critical Care Medicine, Department of Internal Medicine, Korea University, Ansan Hospital, Ansan, Republic of Korea. Electronic address:

Objective: To determine the association between brain structural changes and gait speed in a four-year longitudinal prospective cohort study.

Measurements: A total of 767 well-functioning community-dwelling participants, free of arthritis, silent infarct, stroke, dementia, head injury, and cancer, completed baseline brain magnetic resonance imaging scan and gait speed tests between 2011 and 2014, and follow-up tests between 2015 and 2017. The gait test consisted of measuring the elapsed time to walk four meters at usual speed. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S05315565183053
Publisher Site
http://dx.doi.org/10.1016/j.exger.2019.01.004DOI Listing
April 2019
5 Reads

The age-related changes and differences in energy metabolism and glutamate-glutamine recycling in the d-gal-induced and naturally occurring senescent astrocytes in vitro.

Exp Gerontol 2019 Apr 2;118:9-18. Epub 2019 Jan 2.

Zhejiang Provincial Key Laboratory of Medical Genetics, Key Laboratory of Laboratory Medicine, Ministry of Education, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou 325035, PR China. Electronic address:

Previously, we successfully established a d-galactose (d-gal)-induced astrocyte aging model in vitro. However, whether the changes in the aged astrocytes induced by d-gal are similar to those occurred in naturally are unknown. Therefore, in current study, we simultaneously established d-gal-induced and naturally aged astrocyte aging models in vitro to explore the age-related changes and to compare the differences in these two astrocyte aging models. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.exger.2018.12.018DOI Listing
April 2019
1 Read

Deficiency of Bmal1 disrupts the diurnal rhythm of haemostasis.

Exp Gerontol 2019 Apr 2;118:1-8. Epub 2019 Jan 2.

Center for Molecular and Vascular Biology, Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium. Electronic address:

Background: Mice deficient in the circadian clock gene BMAL1 (Brain and Muscle ARNT-like protein-1) exhibit a hypercoagulable state and an enhanced arterial and venous thrombogenicity, which aggravates with age. We investigated the effect of BMAL1 deficiency in mice at a different age on the diurnal rhythm of factors involved in coagulation and fibrinolysis.

Materials And Methods: Hepatic, cardiac and brain tissues were isolated from 10- and 25-weeks-old Bmal1-deficient (BMAL1) and wild-type (BMAL1) mice at ZT2 and at ZT14 to analyze the mRNA expression level of genes involved in coagulation and fibrinolysis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.exger.2018.12.017DOI Listing
April 2019
2 Reads

Repeated sit-to-stand exercise enhances muscle strength and reduces lower body muscular demands in physically frail elders.

Exp Gerontol 2019 Feb 27;116:86-92. Epub 2018 Dec 27.

Department of Sports and Life Science, National Institute of Fitness and Sports in KANOYA, 1 Shiromizucho, Kanoya, Kagoshima 891-2393, Japan.

Purpose: To examine the effect of a conditioning program consisting of repeated sit-to-stand exercise on knee extensor strength and muscular activities during body mass-based squat movement in physically frail elders.

Methods: Fourteen men and women aged 75 to 88 years who used the long-term care insurance system participated in the 12-week training program (48 reps/session, 3 sessions/week). Isometric knee extension torque (KET) during a maximum voluntary contraction (MVC) and electromyogram (EMG) activities of the rectus femoris and vastus lateralis muscles during the MVC and a body mass-based squat task were determined at baseline, and following 4 and 12 weeks training. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S05315565183070
Publisher Site
http://dx.doi.org/10.1016/j.exger.2018.12.016DOI Listing
February 2019
2 Reads

Healthy aging: A bibliometric analysis of the literature.

Exp Gerontol 2019 Feb 24;116:93-105. Epub 2018 Dec 24.

Department of Occupational and Environmental Health, School of Health Sciences, Wuhan University, No. 115, Dong Hu Street, Wuhan, Hubei 430071, China. Electronic address:

Due to dramatic growth of the aging population worldwide, there has been an urgent call for a public health strategy to manage healthy aging, with the ultimate goal being advancement of aging research. Considerable progress has been made in uncovering the mystery of aging process using multidisciplinary methods. There is a growing consensus in the field that aging traits which were originally thought to be disparate are likely to be interconnected. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S05315565183046
Publisher Site
http://dx.doi.org/10.1016/j.exger.2018.11.014DOI Listing
February 2019
12 Reads

Sex differences in healthy life expectancy among nonagenarians: A multistate survival model using data from the Vitality 90+ study.

Exp Gerontol 2019 Feb 24;116:80-85. Epub 2018 Dec 24.

Faculty of Social Sciences (Health Sciences), Tampere University and Gerontology Research Center, Finland.

Objectives: Little is known about sex differences in healthy life expectancy among the oldest old, the fastest growing segment of the older population. This study examines sex differences in total, healthy and unhealthy life expectancy among nonagenarians.

Methods: Longitudinal data of 884 older adults aged 90 and over participating in the Vitality 90+ study (Tampere, Finland) were used, including 2501 observations (health or death states) from 5 measurement waves between 2001 and 2014. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.exger.2018.12.015DOI Listing
February 2019
1 Read

Cardiac function is not associated with glucose control in older women.

Exp Gerontol 2019 Feb 20;116:31-36. Epub 2018 Dec 20.

Cardiovascular Research Centre, Institutes of Cellular and Genetic Medicine, Newcastle University, UK; Freeman Hospital and Royal Victoria Infirmary, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK; RCUK Newcastle Centre for Ageing and Vitality, Newcastle University, Newcastle upon Tyne, UK. Electronic address:

The present study evaluated the effect of age on glucose tolerance and cardiac function and assessed the relationship between metabolic control and cardiac function and performance. Thirty-four healthy women aged 40 to 81 years were divided into two age groups: younger (≤50 years of age, N = 19) and older (≥60 years of age, N = 15). Participants performed an oral glucose tolerance test and a graded cardiopulmonary exercise test with non-invasive haemodynamic measurements. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S05315565183029
Publisher Site
http://dx.doi.org/10.1016/j.exger.2018.12.014DOI Listing
February 2019
6 Reads

The role of arginase in aging: A systematic review.

Exp Gerontol 2019 Feb 19;116:54-73. Epub 2018 Dec 19.

PEPITE EA4267, FHU INCREASE, Univ. Bourgogne Franche-Comté, F-25030 Besançon, France.

Aging is a normal, progressive and multi-step degeneration in the physiological functions and metabolic processes of living organisms until death. It represents the main risk factor for many diseases (e.g. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S05315565183070
Publisher Site
http://dx.doi.org/10.1016/j.exger.2018.12.011DOI Listing
February 2019
4 Reads

Effect of all-extremity high-intensity interval training vs. moderate-intensity continuous training on aerobic fitness in middle-aged and older adults with type 2 diabetes: A randomized controlled trial.

Exp Gerontol 2019 Feb 18;116:46-53. Epub 2018 Dec 18.

Department of Applied Physiology & Kinesiology, University of Florida, Gainesville, FL, United States of America. Electronic address:

Aging and diabetes are associated with decreased aerobic fitness, an independent predictor of mortality. Aerobic exercise is prescribed to improve aerobic fitness; however, middle-aged/older diabetic patients often suffer from mobility limitations which restrict walking. Non-weight-bearing/low-impact exercise is recommended but the optimal exercise prescription is uncertain. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.exger.2018.12.013DOI Listing
February 2019
2 Reads

Longitudinal study of sleep and diurnal rhythms in Drosophila ananassae.

Exp Gerontol 2019 Feb 17;116:74-79. Epub 2018 Dec 17.

Department of Psychology, University of Arizona, Tucson, AZ, United States of America; Department of Neurology, University of Arizona, Tucson, AZ, United States of America; BIO5 and McKnight Brain Research Institutes, Tucson, AZ, United States of America. Electronic address:

Mistiming of circadian rhythms impairs quality of life. The sleep fragmentation that results can lead to fatigue, mood alteration, and short-term memory problems. Unfortunately, this suite occurs in humans as we age. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.exger.2018.12.010DOI Listing
February 2019
1 Read