5,071 results match your criteria Experimental Gerontology[Journal]


Exercise preconditioning attenuates hind limb unloading-induced gastrocnemius muscle atrophy possibly via the HDAC4/Gadd45 axis in old rats.

Exp Gerontol 2019 Apr 19. Epub 2019 Apr 19.

Graduate School of Health and Sports Science, Juntendo University, 1-1 Hirakagakuendai, Inzai, Chiba 270-1695, Japan. Electronic address:

The mechanisms involved in unloading-induced skeletal muscle loss may be age-specific, and the evidence for exercise preconditioning-induced protection against disuse muscle atrophy in aged rats is limited. Therefore, in this study, we investigated age-related differences in the activation of the HDAC4/Gadd45α pathway following hindlimb unloading (HU). We also assessed the protective effect of preconditioning exercise on this pathway in young and old rat gastrocnemius muscle. Read More

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http://dx.doi.org/10.1016/j.exger.2019.04.010DOI Listing

Effects of moderate mountain hiking and balneotherapy on community-dwelling older people: A randomized controlled trial.

Exp Gerontol 2019 Apr 17. Epub 2019 Apr 17.

Institute of Ecomedicine, Paracelsus Medical University Salzburg, 5020 Salzburg, Austria. Electronic address:

Background: Population aging is one of the greatest socio-economic challenges of the 21st century, as aging is a well-known risk factor for the development of chronic diseases and functional disabilities. A sedentary life-style promotes the progression of chronic diseases and impaired mobility in older people. Therefore, physical activity is essential for healthy aging. Read More

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http://dx.doi.org/10.1016/j.exger.2019.04.006DOI Listing

Inhibition of TLR9 attenuates skeletal muscle fibrosis in aged sarcopenic mice via the p53/SIRT1 pathway.

Exp Gerontol 2019 Apr 16. Epub 2019 Apr 16.

The First Affiliated Hospital of Chongqing Medical University, Friendship Road 1, YuZhong District, Chongqing 400016, China. Electronic address:

Sarcopenia is an age-related syndrome characterized by a gradual loss of muscle mass and function, but its pathophysiological mechanism remains unclear. Skeletal muscle extracellular matrix (ECM) remodeling is an important pathological change in sarcopenia, and fibrosis is the most obvious manifestation of this change. We found that the expression of the immunoreceptor Toll-like receptor 9 (TLR9) is significantly increased in skeletal muscle in aged mice and is positively related to muscle fibrosis. Read More

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http://dx.doi.org/10.1016/j.exger.2019.04.008DOI Listing

Erythropoietin does not improve fracture healing in aged mice.

Exp Gerontol 2019 Apr 16;122:1-9. Epub 2019 Apr 16.

Department of Trauma, Hand and Reconstructive Surgery, Saarland University, 66421 Homburg, Germany; Institute for Clinical & Experimental Surgery, Saarland University, 66421 Homburg, Germany.

Fracture healing in the elderly is associated with a declined healing potential caused by multiple factors including a delay of vascularization. Erythropoietin (EPO) has been demonstrated to improve vascularization and fracture healing in adult mice. We, therefore, hypothesized that EPO in aged mice also improves fracture healing. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S05315565193012
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http://dx.doi.org/10.1016/j.exger.2019.04.005DOI Listing
April 2019
2 Reads

Multicomponent exercise and the hallmarks of frailty: Considerations on cognitive impairment and acute hospitalization.

Exp Gerontol 2019 Apr 14;122:10-14. Epub 2019 Apr 14.

Department of Health Sciences, Navarrabiomed, IdiSNA, CIBER of Frailty and Healthy Aging (CIBERFES), Instituto de Salud Carlos III, Public University of Navarra, Pamplona, Navarra, Spain. Electronic address:

Frailty syndrome encompasses several physical hallmarks such as loss of muscle strength, power output and mass, which leads to poor gait ability, fatigue, falls and overall difficulty to perform activities of daily living. On the other hand, physical exercise interventions induce marked improvements in frailty physical hallmarks (e.g. Read More

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http://dx.doi.org/10.1016/j.exger.2019.04.007DOI Listing
April 2019
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Association of health empowerment and handgrip strength with intention to participate in physical activity among community-dwelling older adults.

Exp Gerontol 2019 Apr 10;121:99-105. Epub 2019 Apr 10.

University of West Florida, 11000 University Parkway #72/220, Pensacola, FL 32514, United States. Electronic address:

Introduction: Health empowerment is an individual's perceived control and competence related to health and health care. The projected increased growth of the older adult population calls for a health-related empowerment movement in health education that targets older adults. Using the theory of planned behavior, the purpose of this study was to investigate the association of health empowerment and handgrip strength with intention to participate in physical activity among older adults. Read More

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http://dx.doi.org/10.1016/j.exger.2019.04.001DOI Listing

Exercise as a potential modulator of inflammation in patients with Alzheimer's disease measured in cerebrospinal fluid and plasma.

Exp Gerontol 2019 Apr 11;121:91-98. Epub 2019 Apr 11.

Danish Dementia Research Centre, Department of Neurology, Rigshospitalet University of Copenhagen, DK-2100 Copenhagen, Denmark. Electronic address:

Background: Neuroinflammation is recognized as part of the pathological progression of Alzheimer's disease (AD), but the molecular mechanisms are still not entirely clear. Systemically, physical exercise has shown to have a positive modulating effect on markers of inflammation. It is not known if this general effect also takes place in the central nervous system in AD. Read More

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http://dx.doi.org/10.1016/j.exger.2019.04.003DOI Listing
April 2019
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Effects of free weights and machine training on muscular strength in high-functioning older adults.

Exp Gerontol 2019 Apr 10;122:15-24. Epub 2019 Apr 10.

Dept. of Sport and Exercise Science, University of Stuttgart, Stuttgart, Germany.

Background: Resistance training is assumed to be a key player in counteracting the age-related decline of functional capacity as well as the incidence of falls in older adults. Functional training using free weights is presumed to mimic daily activities, but there is a lack of studies comparing free weight training with barbells and machine training in older adults. The purpose of this study was to evaluate the development of muscle strength for high resistance training in high functioning older people for machines as well as free-weights as well as testing the feasibility of free weight training for this target group. Read More

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http://dx.doi.org/10.1016/j.exger.2019.03.012DOI Listing

Commentary: High-speed resistance training in elderly women: Effects of cluster training sets on functional performance and quality of life.

Exp Gerontol 2019 Apr 10;121:79-80. Epub 2019 Apr 10.

Pontifical Catholic University of Minas Gerais, Department of Physical Education, Belo Horizonte, Brazil.

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https://linkinghub.elsevier.com/retrieve/pii/S05315565193004
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http://dx.doi.org/10.1016/j.exger.2019.04.004DOI Listing
April 2019
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Muscle mass and strength gains following 6 months of resistance type exercise training are only partly preserved within one year with autonomous exercise continuation in older adults.

Exp Gerontol 2019 Apr 9;121:71-78. Epub 2019 Apr 9.

NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center+, Maastricht, the Netherlands.

Introduction: Although resistance type exercise training (RT) effectively increases muscle mass and strength in older individuals, it remains unclear whether gains in muscle mass and strength are maintained without continued supervised training. We assessed the capacity of older individuals to maintain muscle mass and strength gains one year after partaking in a successful RT program.

Methods: Fifty-three healthy older adults performed a 24-wk supervised RT program. Read More

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http://dx.doi.org/10.1016/j.exger.2019.04.002DOI Listing

In vitro model of chronological aging of adipocytes: Interrelationships with hypoxia and oxidation.

Exp Gerontol 2019 Mar 27;121:81-90. Epub 2019 Mar 27.

Division of Geriatric Medicine, Department of Surgery, Dentistry, Pediatric and Gynecology, University of Verona, Verona, Italy.

Aging is a physiological process characterized by an age-progressive decline in intrinsic physiological functions, with an increased risk of developing chronic metabolic conditions, such as insulin resistance and diabetes. Furthermore, from a physiopathological point of view, several authors describe an association between oxidative stress, hypoxia and these metabolic conditions. It had been suggested that adipose tissue (AT) dysfunction, senescent cell accumulation and proinflammatory pathways may be involved in this processes. Read More

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http://dx.doi.org/10.1016/j.exger.2019.03.011DOI Listing
March 2019
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Mitochondrial mRNA translation initiation contributes to oxidative metabolism in the myocardia of aged, obese mice.

Exp Gerontol 2019 Mar 27;121:62-70. Epub 2019 Mar 27.

Integrative Muscle Metabolism Laboratory, Department of Health, Human Performance and Recreation, University of Arkansas, Fayetteville, AR, United States of America. Electronic address:

Being both advanced in age and obese each contribute to cardiac hypertrophy in a unique manner. Electron transport complexes I and IV are implicated in deficient electron transport during cardiomyopathies and contain the majority of protein subunits that are transcribed and translated by machinery localized within the mitochondria.

Purpose: To assess myocardial mt-mRNA translation factors in relation to mitochondrial content and mtDNA-encoded protein using a mouse model of aged obesity and to test the relationship of mt-mRNA translation initiation factor 2 (mtIF2) to oxidative capacity and the cellular oxidation-reduction (redox) state in cardiomyocytes. Read More

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http://dx.doi.org/10.1016/j.exger.2019.03.009DOI Listing
March 2019
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Study of the association of DHEAS, testosterone and cortisol with S-Klotho plasma levels in healthy sedentary middle-aged adults.

Exp Gerontol 2019 Mar 27;121:55-61. Epub 2019 Mar 27.

Department of Medical Physiology, School of Medicine, University of Granada, 18016 Granada, Spain.

Background: α-Klotho is a recently discovered gene that accelerates ageing when disrupted and extends lifespan when overexpressed. The age-related decline in DHEAS and testosterone secretion and the increase in cortisol are associated with a rise of frailty and mortality.

Objective: To investigate the association of DHEAS, cortisol and testosterone plasma levels with S-Klotho plasma levels in healthy sedentary middle-aged adults. Read More

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http://dx.doi.org/10.1016/j.exger.2019.03.010DOI Listing
March 2019
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Ageing differently: Sex-dependent ageing rates in Daphnia magna.

Exp Gerontol 2019 Mar 25;121:33-45. Epub 2019 Mar 25.

Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK. Electronic address:

Ageing is defined as the gradual decline of normal physiological functions in a time-dependent manner. Significant progress has been made in characterising the regulatory processes involved in the mechanisms of ageing which would have been hindered without the use of model organisms. Use of alternative model organisms greatly diversifies our understanding of different factors underpinning the ageing process and the potential translation for human application. Read More

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http://dx.doi.org/10.1016/j.exger.2019.03.008DOI Listing

The effect of resistance exercise upon age-related systemic and local skeletal muscle inflammation.

Exp Gerontol 2019 Mar 21;121:19-32. Epub 2019 Mar 21.

Institute of Sports Medicine Copenhagen, Department of Orthopedic Surgery M, Bispebjerg Hospital and Center for Healthy Aging, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.

Aim: Chronic inflammation increases with age and is correlated positively to visceral fat mass, but inversely to muscle mass. We investigated the hypothesis that resistance training would increase muscle mass and strength together with a concomitant drop in local and systemic inflammation level independent of any changes in visceral fat tissue in elderly.

Methods: 25 subjects (mean 67, range 62-70 years) were randomized to 1 year of heavy resistance training (HRT) or control (CON), and tested at 0, 4 and 12 months for physical performance, body composition (DXA), vastus lateralis muscle area (MRI) local and systemic inflammation (blood and muscle). Read More

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http://dx.doi.org/10.1016/j.exger.2019.03.007DOI Listing
March 2019
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Serum adiponectin is associated with body composition and cognitive and psychological status in older adults living in long-term nursing homes.

Exp Gerontol 2019 Mar 15;121:1-9. Epub 2019 Mar 15.

Department of Physiology, Faculty of Medicine and Nursing, University of the Basque Country (UPV/EHU), P.O. Box 699, 48080 Bilbao, Bizkaia, Spain. Electronic address:

Frailty is a geriatric syndrome characterized by decreasing functional reserves and increasing vulnerability to falls, injuries and declining health, leading to dependence upon caregivers. Frailty is associated not only with physical decline, but also with cognitive and psychological impairments in aging people. Higher serum adiponectin concentration has been linked to better performance on frailty measures but also to worse cognitive status. Read More

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http://dx.doi.org/10.1016/j.exger.2019.03.005DOI Listing

A longitudinal study of the stability, variability, and interdependencies among late-differentiated T and NK cell subsets in older adults.

Exp Gerontol 2019 Mar 15;121:46-54. Epub 2019 Mar 15.

Department of Psychology, College of Arts and Sciences, University of Kentucky, Lexington, KY, United States of America. Electronic address:

The stability and variability of older adults' late-differentiated peripheral blood T and natural killer (NK) cells over time remains incompletely quantified or understood. We examined the variability and change over time in T and NK cell subsets in a longitudinal sample of older adults; the effects of sex, cytomegalovirus (CMV) serostatus, and chronic disease severity on immune levels and trajectories; and interdependencies among T and NK cell subsets. Older adults (N = 149, age 64-94 years, 42% male) provided blood every 6 months for 2. Read More

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http://dx.doi.org/10.1016/j.exger.2019.03.006DOI Listing

Comorbid sensorimotor and emotional profiles in the forced swim test immobility and predictive value of a single assay in very old female mice.

Exp Gerontol 2019 Jun 14;120:107-112. Epub 2019 Mar 14.

Institute of Neuroscience, Universitat Autònoma de Barcelona, 08193, Cerdanyola del Vallès, Barcelona, Spain; Medical Psychology Unit, Department of Psychiatry and Forensic Medicine, School of Medicine, Campus Bellaterra, Universitat Autònoma de Barcelona, 08193, Cerdanyola del Vallès, Barcelona, Spain. Electronic address:

The increase of prevalence of mental health problems in the elderly due to the aging of the population becomes an outstanding issue since in most individuals it happens in an already complex multimorbid scenario that may include frailty and age-related medical conditions. Depression, soon the major cause of global disease burden, can be found as an age-related comorbidity and frailty, or as part of neurodegenerative diseases and where females are more vulnerable to it. Thought the multifactorial aetiology and heterogeneous nature of depression render it difficult to be modelled in animals, active behaviours elicited in the Forced Swimming Test (FST) are used to screen antidepressant treatments. Read More

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http://dx.doi.org/10.1016/j.exger.2019.03.004DOI Listing

Fall-related healthcare use and mortality among older adults in the Netherlands, 1997-2016.

Exp Gerontol 2019 Jun 13;120:95-100. Epub 2019 Mar 13.

Erasmus MC, University Medical Center Rotterdam, Department of Public Health, the Netherlands.

Objectives: Fall-related injuries are a leading cause of morbidity among older adults, leading to a high healthcare consumption and mortality. We aim to describe and quantify time trends of fall-related healthcare use and mortality among adults aged ≥65 years in the Netherlands, 1997-2016.

Design: Data were extracted from the Dutch Injury Surveillance System, Dutch Hospital Discharge Registry, and Cause-of-Death Statistics Netherlands, by age, sex, diagnosis, injury location, and year. Read More

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http://dx.doi.org/10.1016/j.exger.2019.03.003DOI Listing

Mouse models in modeling aging and cancer.

Exp Gerontol 2019 Jun 12;120:88-94. Epub 2019 Mar 12.

Faculty of Environmental Science and Engineering, Kunming University of Science and Technology, Kunming, Yunnan 650500, China; Lab of Molecular Genetics of Aging & Tumor, Medical School, Kunming University of Science and Technology, Kunming, Yunnan 650500, China. Electronic address:

Mouse models have been widely used in the research of human diseases. Aging, just as cancer, is influenced by the interaction of various genetic and environmental factors. Currently, aging could be induced by many mechanism, including telomere dysfunction, oxidase stress, DNA damage and epigenetic changes. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S05315565183066
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http://dx.doi.org/10.1016/j.exger.2019.03.002DOI Listing
June 2019
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Periodized and non-periodized resistance training programs on body composition and physical function of older women.

Exp Gerontol 2019 Mar 9;121:10-18. Epub 2019 Mar 9.

Applied Kinesiology Laboratory-AKL, School of Physical Education, University of Campinas, Av. Érico Veríssimo, 701, Cidade Universitária "Zeferino Vaz", Barão Geraldo, CEP: 13.083-851 Campinas, SP, Brazil.

Background And Purpose: Although combining classical resistance (RT) and power training (PT) might be an efficient strategy to achieve optimal enhancements in body composition and physical function in older adults, the most effective approach to combine these different types of exercise training is still unknown. Periodization, an organizational model that refers to a succession of cycle that will vary in exercise intensity and/or volume to allow for the training stimulus to remain biologically challenging and effective, may represent an interesting approach. Among the different types of periodization, daily undulating periodization (DUP) has attracted considerable attention given its superiority in comparison to nonperiodized (NP) RT programs to elicit neuromuscular improvements in young adults. Read More

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http://dx.doi.org/10.1016/j.exger.2019.03.001DOI Listing
March 2019
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Digital behavior change interventions to promote physical activity and/or reduce sedentary behavior in older adults: A systematic review and meta-analysis.

Exp Gerontol 2019 Jun 2;120:68-87. Epub 2019 Mar 2.

The Cambridge Centre for Sport and Exercise Sciences, Anglia Ruskin University, Compass House Annex, Newmarket Road, Cambridge CB5 8DZ, UK.

Background: Physical activity and sedentary behavior are modifiable risk factors for non-communicable disease and healthy ageing, however the majority of older adults remain insufficiently active. Digital behavior change interventions (DBCI) have the potential to reach many older adults to promote physical activity and reduce sedentary time. This study aims to assess the efficacy of DBCI interventions in older adults (≥50 years) on physical activity and sedentary behavior. Read More

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http://dx.doi.org/10.1016/j.exger.2019.02.020DOI Listing
June 2019
3 Reads
3.485 Impact Factor

The relationship between polypharmacy and trajectories of cognitive decline in people with dementia: A large representative cohort study.

Exp Gerontol 2019 Jun 1;120:62-67. Epub 2019 Mar 1.

King's College London, Institute of Psychiatry, Psychology and Neuroscience, London, UK; South London and Maudsley NHS Foundation Trust, London, UK. Electronic address:

Polypharmacy, defined through the number of medications prescribed, has been linked to a range of adverse health outcomes in people with dementia. It is however unclear whether a numerical threshold of concurrently prescribed drugs is a suitable predictor for cognitive decline. We aimed to test associations between polypharmacy and both short-term (six months) and long-term (three years) cognitive trajectories in patients with incident dementia. Read More

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http://dx.doi.org/10.1016/j.exger.2019.02.019DOI Listing
June 2019
3.485 Impact Factor

Corrigendum to "High-speed resistance training in elderly women: Effects of cluster training sets on functional performance and quality of life" [Exp. Gerontol. 110 (September 2018) 216-222].

Exp Gerontol 2019 Jun 1;120:113. Epub 2019 Mar 1.

Department of Health Sciences, Public University of Navarre, CIBER of Frailty and Healthy Aging (CIBERFES), Navarrabiomed, Pamplona, Navarre, Spain.

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http://dx.doi.org/10.1016/j.exger.2019.02.009DOI Listing
June 2019
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Orthostatic hypotension and cognition in older adults: A systematic review and meta-analysis.

Exp Gerontol 2019 Jun 28;120:40-49. Epub 2019 Feb 28.

Department of Medicine and Aged Care, @AgeMelbourne, The Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia; Department of Human Movement Sciences, @AgeAmsterdam, Amsterdam Movement Sciences, Vrije Universiteit, Van der Boechorststraat, Amsterdam, the Netherlands.

Background: Orthostatic hypotension (OH) is common in older adults with reported prevalence rates of 5-40%. A direct link between OH and cognitive performance has been proposed due to impaired vascular autoregulation.

Aim: To systematically assess the literature of the association between OH and cognitive performance in older adults. Read More

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http://dx.doi.org/10.1016/j.exger.2019.02.017DOI Listing

Dual task performance and history of falls in community-dwelling older adults.

Exp Gerontol 2019 Jun 27;120:35-39. Epub 2019 Feb 27.

Faculty of Sport Science, University of Extremadura, Spain. Electronic address:

Introduction: Falls are a common problem for older adults, and the identification of people at high risk of falling is a major challenge to health systems.

Objective: To evaluate the association between the history of falls and single-task Timed Up and Go Test (single TUG) or dual-task TUG variables.

Methods: Three hundred seventy seven community-dwelling older persons, with ages ranging from 65 and 92 years, participated in this cross-sectional study. Read More

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http://dx.doi.org/10.1016/j.exger.2019.02.015DOI Listing
June 2019
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Anti-ageing and anti-Parkinsonian effects of natural flavonol, tambulin from Zanthoxyllum aramatum promotes longevity in Caenorhabditis elegans.

Exp Gerontol 2019 Jun 28;120:50-61. Epub 2019 Feb 28.

Ageing Biology Lab, Microbial Technology and Nematology Department, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow 226015, India. Electronic address:

Ageing is a progressive deterioration in functional and structural well-being of the body, accompanied with age-associated neurological disorders such as Parkinson's disease (PD), Alzheimer's disease and Huntington's disease. PD is marked with motor function decline, progressive neurodegeneration due to aggregation of insoluble α-synuclein in the dopaminergic neuron. Here we investigated the effect of tambulin (3,5-dihydroxy-7,8-dimethoxy-2-(4-methoxyphenyl) chromen-4-one), a hydroxy substituted flavanol isolated from fruits of Zanthoxyllum armatum DC (Family-Rutaceae) for its longevity promoting and neuromodulatory activities using Caenorhabditis elegans model system. Read More

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http://dx.doi.org/10.1016/j.exger.2019.02.016DOI Listing
June 2019
4 Reads
3.485 Impact Factor

The senescent status of endothelial cells affects proliferation, inflammatory profile and SOX2 expression in bone marrow-derived mesenchymal stem cells.

Exp Gerontol 2019 Jun 26;120:21-27. Epub 2019 Feb 26.

Department of Clinical and Molecular Sciences, Polytechnic University of Marche, Ancona, Italy.

Human aging is a physiological process characterized by a chronic low-grade inflammation. Senescence may affect endothelial cells, subsequently involved in the most common age-related diseases (ARDs), as well as mesenchymal stem cells (MSCs) with an impairment of their properties in tissues regeneration. Endothelial cells seem to be able to exert a paracrine effect on BM-MSCs through the secretion of pro-inflammatory factors. Read More

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http://dx.doi.org/10.1016/j.exger.2019.02.014DOI Listing

Nutrition-related parameters predict the health-related quality of life in home care patients.

Exp Gerontol 2019 Jun 26;120:15-20. Epub 2019 Feb 26.

Gazi University, Faculty of Health Sciences, Department of Nutrition and Dietetics, Beşevler, 06500 Ankara, Turkey.

Introduction: There is evidence that nutritional status is one of the major factors affecting quality of life. Low quality of life is an important reason that reflects the risk of malnutrition as well as dependency and frailty.

Objective: The present study aimed to examine nutritional risk factors and sociodemographic features affecting health-related quality of life in home care patients. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S05315565183075
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http://dx.doi.org/10.1016/j.exger.2019.02.018DOI Listing
June 2019
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Lifestyle multidomain intervention, omega-3 supplementation, or both for reducing the risk of developing clinically relevant depressive symptoms in older adults with memory complaints? Secondary analysis from the MAPT trial.

Exp Gerontol 2019 Jun 26;120:28-34. Epub 2019 Feb 26.

Gérontopôle de Toulouse, Institut du Vieillissement, Centre Hospitalo-Universitaire de Toulouse, 37 allée Jules Guesdes, 31000 Toulouse, France; UMR INSERM, 1027 University of Toulouse III, Toulouse, France.

Background: We tested the associations of a lifestyle multidomain intervention (MI), omega-3 supplementation (O3) or their combination with the change of clinically meaningful depressive symptoms in older adults.

Methods: Secondary analysis of the 3-year Multidomain Alzheimer Preventive Trial (MAPT), in which 1679 people, ≥70 years with memory complaints were randomized into: MI, O3, MI + O3, or placebo. MI was composed of nutritional and physical activity counselling and cognitive training. Read More

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http://dx.doi.org/10.1016/j.exger.2019.02.010DOI Listing

Bench stepping with incremental heights improves muscle volume, strength and functional performance in older women.

Exp Gerontol 2019 Jun 22;120:6-14. Epub 2019 Feb 22.

Department of Movement Sciences, Physical Activity, Sports and Health Research Group, KU Leuven, Leuven, Belgium.

Aim: Task-specific exercises such as bench stepping can improve functional ability and reduce falling incidents in older adults. However, such exercises are often not optimized to improve muscle volume and force-velocity characteristics. This study determined the effects of a 12-week stepping program using incremental step heights (STEEP), on muscle volume, strength, power, functional ability and balance performance in older women. Read More

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http://dx.doi.org/10.1016/j.exger.2019.02.013DOI Listing

Continuous intracerebroventricular injection of Porphyromonas gingivalis lipopolysaccharide induces systemic organ dysfunction in a mouse model of Alzheimer's disease.

Exp Gerontol 2019 Jun 17;120:1-5. Epub 2019 Feb 17.

Department of Pharmacology and Molecular Therapeutics, Graduate School of Medical Sciences, Kumamoto University, Japan.

Systemic organ dysfunction is one of the important issues for the patients with Alzheimer's disease (AD) and their caregivers. Recent evidences suggest that periodontitis is a possible risk factor for progression of AD and lipopolysaccharide derived from Porphyromonas gingivalis (Pg-LPS) which is a major periodontopathic bacteria induces cognitive impairment in mice. However, the precise relationships between the brain exposure of Pg-LPS and systemic organ dysfunction in AD patients are still undetermined. Read More

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http://dx.doi.org/10.1016/j.exger.2019.02.007DOI Listing
June 2019
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Long-term stimulation of angiotensin II induced endothelial senescence and dysfunction.

Exp Gerontol 2019 May 16;119:212-220. Epub 2019 Feb 16.

State Key Laboratory of Cardiovascular Disease, FuWai Hospital, National Center for Cardiovascular Diseases, Peking Union Medical College, Chinese Academy of Medical Sciences, Beilishi Road 167, Xicheng District, Beijing 100037, China. Electronic address:

The role of angiotensin II (Ang II) in hypertension has been clarified, but recent studies show that aging-associated arterial changes and those with hypertension as well as atherosclerosis may have some common pathogenesis. This study aimed to clarify the effects of Ang II on endothelial senescence by establishing a replicative senescence model of human umbilical vein endothelial cells (HUVECs) in vitro. The population-doubling level (PDL) was calculated, PDL5 and PDL25 respectively referred to cells cultured for 2 days and 30 days. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S05315565183049
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http://dx.doi.org/10.1016/j.exger.2019.02.012DOI Listing
May 2019
11 Reads

HSF1/HSP pathway in the hippocampus is involved in SIRT1-mediated caloric restriction-induced neuroprotection after surgery in aged mice.

Exp Gerontol 2019 May 14;119:184-192. Epub 2019 Feb 14.

Department of Anesthesia, Zhongshan Hospital, Fudan University, Shanghai 200032, China. Electronic address:

Postoperative cognitive dysfunction is common in the elderly. Endoplasmic reticulum stress (ER-stress) increases neuronal apoptosis after surgery, and chaperone molecules, such as heat shock proteins (HSPs), help reduce unfolded protein reactions, thereby promoting protein homeostasis. Mammal sirtuin1 (SIRT1)-mediated deacetylation of heat shock factor 1 (HSF1) upregulates HSF1 binding to the HSP70 promoter. Read More

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http://dx.doi.org/10.1016/j.exger.2019.02.011DOI Listing
May 2019
2 Reads

Objective physical activity and physical performance in middle-aged and older adults.

Exp Gerontol 2019 May 13;119:203-211. Epub 2019 Feb 13.

Framingham Heart Study, Framingham, MA, USA; Department of General Internal Medicine, Boston University School of Medicine, Boston, MA, USA.

Background: Older adults may have difficulty meeting the Physical Activity (PA) Guidelines. A favorable balance between PA and sedentary time (SED) is an important determinant of physical performance in older adults. Our objective was to explore associations of PA/SED with physical performance across mid-older age in adults without overt mobility disability. Read More

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http://dx.doi.org/10.1016/j.exger.2019.02.003DOI Listing
May 2019
1 Read

Activity and intracellular localization of senescence-associated β-galactosidase in aging Xenopus oocytes and eggs.

Exp Gerontol 2019 May 12;119:157-167. Epub 2019 Feb 12.

Department of Molecular Biosciences, Kyoto Sangyo University, Kamigamo-motoyama, Kita-ku, Kyoto 603-8555, Japan. Electronic address:

Senescence-associated β-galactosidase (SA-β-gal) serves as a marker of senescence in aging somatic cells. However, little is known about SA-β-gal dynamics in aging gamete cells. To address this issue, here we investigated activity and intracellular localization of SA-β-gal in freshly obtained and aging oocytes and eggs of the African clawed frog Xenopus laevis. Read More

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http://dx.doi.org/10.1016/j.exger.2019.02.002DOI Listing

The impact of age on cardiac function and extracellular matrix component expression in adverse post-infarction remodeling in mice.

Exp Gerontol 2019 May 11;119:193-202. Epub 2019 Feb 11.

Ludwig Boltzmann Cluster for Cardiovascular Research at the Center for Biomedical Research, Medical University of Vienna, Waehringer Guertel 18-20, Leitstelle 1Q, 1090 Wien, Austria; Department of Cardiac Surgery, University Hospital St. Poelten, Dunant-Platz 1, 3100 St. Poelten, Austria. Electronic address:

The aim of this study was to describe the potential associations of the expression of matricellular components in adverse post-infarction remodeling of the geriatric heart. In male geriatric (OM, age: 18 months) and young (YM, age: 11 weeks) OF1 mice myocardial infarction (MI) was induced by permanent ligation of the left anterior descending coronary artery. Cardiac function was evaluated by MRI. Read More

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http://dx.doi.org/10.1016/j.exger.2019.02.008DOI Listing
May 2019
1 Read

Immunosenescence in honey bees (Apis mellifera L.) is caused by intrinsic senescence and behavioral physiology.

Exp Gerontol 2019 May 8;119:174-183. Epub 2019 Feb 8.

Departamento de Biologia, Faculdade de Filosofia Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil.

Young honey bee workers (0 to 2-3 weeks old) perform tasks inside the colony, including brood care (nursing), whereas older workers undergo foraging tasks during the next 3-4 weeks, when an intrinsic senescence program culminates in worker death. We hypothesized that foragers are less able to react to immune system stimulation than nurse bees and that this difference is due to an inefficient immune response in foragers. To test this hypothesis, we used an experimental design that allowed us to uncouple chronological age and behavior status (nursing/foraging). Read More

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http://dx.doi.org/10.1016/j.exger.2019.02.005DOI Listing
May 2019
5 Reads

Potassium restriction boosts vacuolar acidity and extends lifespan in yeast.

Exp Gerontol 2019 Jun 8;120:101-106. Epub 2019 Feb 8.

Buck Institute for Research on Aging, Novato, CA, United States of America; Department of Plant and Microbial Biology, UC Berkeley, Berkeley, CA, United States of America. Electronic address:

Lysosome function is compromised during aging and in many disease states. Interventions that promote lysosomal activity and acidification are thus of prime interest as treatments for longevity and health. Intracellular pH can be controlled by the exchange of protons for inorganic ions, and in cells from microbes to man, when potassium is restricted in the growth medium, the cytoplasm becomes acidified. Read More

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http://dx.doi.org/10.1016/j.exger.2019.02.001DOI Listing
June 2019
4 Reads

Sex-specific stress tolerance, proteolysis, and lifespan in the invertebrate Tigriopus californicus.

Exp Gerontol 2019 May 7;119:146-156. Epub 2019 Feb 7.

Department of Biological Sciences, Wrigley Institute for Environmental Studies, University of Southern California, Los Angeles, CA 90089, USA. Electronic address:

Because stress tolerance and longevity are mechanistically and phenotypically linked, the sex with higher acute stress tolerance might be expected to also live longer. On the other hand, the association between stress tolerance and lifespan may be complicated by tradeoffs between acute tolerance and long-term survival. Here we use the copepod Tigriopus californicus to test for sex differences in stress resistance, proteolytic activity and longevity. Read More

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http://dx.doi.org/10.1016/j.exger.2019.02.006DOI Listing
May 2019
2 Reads

Diabetic neuropathies influence recovery from hip-fracture surgery in older persons with diabetes.

Exp Gerontol 2019 May 7;119:168-173. Epub 2019 Feb 7.

Healthy Aging Research Center, Chang Gung University, 259 Wenhua 1st Road, Guishan District, Taoyuan 33302, Taiwan; School of Nursing, College of Medicine, Chang Gung University, 259 Wenhua 1st Road, Guishan District, Taoyuan 33302, Taiwan; Department of Orthopedic Surgery, Linkou Chang Gung Memorial Hospital, 5 Fuxing Street, Guishan District, Taoyuan 33305, Taiwan; Department of Nursing, Kaohsiung Chang Gung Memorial Hospital, 123 Dapi Road, Niaosng District, Kaohsiung 83301, Taiwan; Department of Gerontology and Health Care Management, Chang Gung University of Science and Technology, 261 Wenhwa 1st Road, Guishan District, Taoyuan 33303, Taiwan. Electronic address:

Background/objectives: To explore the impact of diabetic peripheral neuropathy (DPN) on the recovery of older persons with diabetes mellitus (DM) after hip-fracture surgery.

Design, Setting, Participants: Secondary data for this study came from a clinical trial on the effectiveness of a DM-specific care model for 176 older persons (age ≥ 60) with DM over 2 years following hip-fracture surgery at a medical center in Taiwan. In the original trial, the experimental group (n = 88) received DM-specific care comprising diabetes care plus subacute care, and the control group (n = 88) received only usual care. Read More

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http://dx.doi.org/10.1016/j.exger.2019.02.004DOI Listing
May 2019
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Elite athletes have longer telomeres than sedentary subjects: A meta-analysis.

Exp Gerontol 2019 May 6;119:138-145. Epub 2019 Feb 6.

Universidade Federal do Pará - UFPA, Pós-Graduação em Genética e Biologia Molecular, Rua Augusto Corrêa 1, Belém 66075-110, PA, Brazil.

The aim of this meta-analysis was to investigate the effects of high levels of physical activity (in elite athletes) and sedentary lifestyle on telomere length. Our meta-analysis was carried out using the following electronic databases: PubMed, Cochrane Library, LILACS, Science Direct and EBSCO. After study selection, nine articles were included in our meta-analysis. Read More

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http://dx.doi.org/10.1016/j.exger.2019.01.023DOI Listing
May 2019
1 Read

Coupling lifespan and aging? The age at onset of body mass decline associates positively with sex-specific lifespan but negatively with environment-specific lifespan.

Exp Gerontol 2019 May 31;119:111-119. Epub 2019 Jan 31.

Groningen Institute for Evolutionary Life Sciences, University of Groningen, Groningen, the Netherlands.

Whether lifespan scales to age-associated changes in health and disease is an urgent question in societies with increasing lifespan. Body mass is associated with organismal functioning in many species, and often changes with age. We here tested in zebra finches whether two factors that decreased lifespan, sex and poor environmental quality, accelerated the onset of body mass declines. Read More

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http://dx.doi.org/10.1016/j.exger.2019.01.030DOI Listing

Sarcopenia-related parameters in adults with Down syndrome: A cross-sectional exploratory study.

Exp Gerontol 2019 May 30;119:93-99. Epub 2019 Jan 30.

Fondazione Policlinico Universitario "Agostino Gemelli" IRCCS, Rome, Italy.

Background: People with Down syndrome (DS) experience premature aging. Whether this accelerated aging also involves early declines in muscle mass, strength and physical performance is presently unclear. The present study investigated the prevalence of sarcopenia parameters in adults with DS. Read More

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http://dx.doi.org/10.1016/j.exger.2019.01.028DOI Listing
May 2019
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Exogenous testosterone alleviates cardiac fibrosis and apoptosis via Gas6/Axl pathway in the senescent mice.

Exp Gerontol 2019 May 30;119:128-137. Epub 2019 Jan 30.

The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese Ministry of Health and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Department of Cardiology, Qilu Hospital of Shandong University, Jinan, China. Electronic address:

Background: Androgen has been implicated in aging-related cardiac remodeling, but its precise role in aging heart remains controversial. We aimed to investigate the role of testosterone in the development of aging-related cardiac remodeling and the mechanisms involved.

Methods: Wild type and Axl knockout mice (Axl) were randomized into three groups: the young group (n = 30, 3 months old), the aging group (n = 30, 18 months old), the testosterone undecanoate treatment group (TU, n = 30, 18 months old). Read More

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http://dx.doi.org/10.1016/j.exger.2019.01.029DOI Listing
May 2019
3.485 Impact Factor

Autophagy in Alzheimer's disease and promising modulatory effects of herbal medicine.

Exp Gerontol 2019 May 30;119:100-110. Epub 2019 Jan 30.

Integrated Chinese and Western Medicine postdoctoral research station, Jinan University, Guangzhou 510632, China; Shenzhen Institute of Geriatrics, Shenzhen 518020, China; The First Affiliated Hospital of Shenzhen University, Shenzhen 518035, China. Electronic address:

Alzheimer's disease (AD) is a progressive and unremitting neurodegenerative disorder characterized by memory loss and cognitive impairment. It affects the quality of life of victims severely. The prevalence of AD has been increasing in recent years. Read More

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http://dx.doi.org/10.1016/j.exger.2019.01.027DOI Listing
May 2019
3 Reads

Effect of pre-exercise and post-exercise creatine supplementation on bone mineral content and density in healthy aging adults.

Exp Gerontol 2019 May 29;119:89-92. Epub 2019 Jan 29.

Faculty of Kinesiology and Health Studies, University of Regina, Regina, SK, Canada.

Creatine supplementation, immediately before and immediately following resistance training, has been shown to increase muscle mass and strength. However, the effects of pre- exercise and post-exercise creatine supplementation on aging bone mineral content (BMC) and density (BMD) is unknown. Using a double-blind, repeated measures design, aging adults were randomized to one of three groups: creatine before (CR-B: n = 15; 53 ± 3 years, 170. Read More

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http://dx.doi.org/10.1016/j.exger.2019.01.025DOI Listing
May 2019
4 Reads
3.485 Impact Factor

Cardioprotection by spermidine does not depend on structural characteristics of the myocardial microcirculation in aged mice.

Exp Gerontol 2019 May 28;119:82-88. Epub 2019 Jan 28.

Institute of Functional and Applied Anatomy, Hannover Medical School, 30625 Hannover, Germany; Cluster of Excellence REBIRTH (From Regenerative Biology to Reconstructive Therapy), Hannover, Germany; Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Hannover, Germany. Electronic address:

Aims: Ageing is associated with cardiovascular disease and reduced cardiac function. This cardiac functional decline is accompanied by cardiac remodeling and alterations in cardiomyocyte composition. Recently, it was shown that the natural polyamine spermidine preserves cardiac function and cardiomyocyte composition in old mice. Read More

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http://dx.doi.org/10.1016/j.exger.2019.01.026DOI Listing

Influence of aging and visual feedback on the stability of hand grip control in elderly adults.

Exp Gerontol 2019 May 26;119:74-81. Epub 2019 Jan 26.

Masters Program in Long-Term Care & School of Gerontology Health Management, College of Nursing, Taipei Medical University, 250 Wu-Xing Street, Taipei 110, Taiwan, ROC.

Aging causes a gradual decrease in maximal grip strength and leads many elderly people to have to rely on visual feedback to compensate for poorer muscle strength in performing daily activities and preventing accidents. Previous studies have investigated age and visual feedback-related changes in grip strength. However, little is known about methods of determining the quality and stability of hand grip strength control in the elderly, which is important for understanding their ability to generate grip force when handling objects with and without visual feedback in daily living. Read More

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http://dx.doi.org/10.1016/j.exger.2019.01.024DOI Listing
May 2019
1 Read

Nrf2 deficiency exacerbates frailty and sarcopenia by impairing skeletal muscle mitochondrial biogenesis and dynamics in an age-dependent manner.

Exp Gerontol 2019 May 25;119:61-73. Epub 2019 Jan 25.

Department of Gastrointestinal Surgery, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China; Shanghai Tenth People's Hospital Chongming Branch Affiliated to Tongji University, Shanghai, China. Electronic address:

Aim: Mitochondrial dysfunction during aging is a key factor that contributes to sarcopenia. Nuclear factor erythroid 2-related factor 2 (Nrf2) has been increasingly recognized to regulate mitochondrial function. The present study aimed to investigate the role of Nrf2 in the development of frailty and sarcopenia during aging, and to demonstrate whether Nrf2 contributes to the maintenance of muscle mass and function by regulation of mitochondrial biogenesis and dynamics during the aging process. Read More

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http://dx.doi.org/10.1016/j.exger.2019.01.022DOI Listing
May 2019
1 Read