417 results match your criteria Experimental Diabetes Research [Journal]


Glucagon-like peptide-1 and diabetes 2012.

Exp Diabetes Res 2012 31;2012:768760. Epub 2012 Dec 31.

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http://dx.doi.org/10.1155/2012/768760DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3566481PMC
May 2013
5 Reads
1 Citation
3.540 Impact Factor

Impact of GLP-1 receptor agonists on major gastrointestinal disorders for type 2 diabetes mellitus: a mixed treatment comparison meta-analysis.

Exp Diabetes Res 2012 26;2012:230624. Epub 2012 Dec 26.

Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Centre, Beijing 100191, China.

Aim: We aimed to integrate evidence from all randomized controlled trials (RCTs) and assess the impact of different doses of exenatide or liraglutide on major gastrointestinal adverse events (GIAEs) in type 2 diabetes (T2DM).

Methods: RCTs evaluating different doses of exenatide and liraglutide against placebo or an active comparator with treatment duration ≥4 weeks were searched and reviewed. A total of 35, 32 and 28 RCTs met the selection criteria evaluated for nausea, vomiting, and diarrhea, respectively. Read More

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http://dx.doi.org/10.1155/2012/230624DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3540917PMC
May 2013
9 Reads

5HT(2A) and 5HT(2B) receptors contribute to serotonin-induced vascular dysfunction in diabetes.

Exp Diabetes Res 2012 30;2012:398406. Epub 2012 Dec 30.

Iowa City Veterans Affairs Health Care System, Research Service (151), 601 Highway 6 West, Iowa City, IA 52246, USA.

Although 5HT(2A) receptors mediate contractions of normal arteries to serotonin (5HT), in some cardiovascular diseases, other receptor subtypes contribute to the marked increase in serotonin contractions. We hypothesized that enhanced contractions of arteries from diabetics to 5HT are mediated by an increased contribution from multiple 5HT receptor subtypes. We compared responses to selective 5HT receptor agonists and expression of 5HT receptor isoforms (5HT(1B), 5HT(2A), and 5HT(2B)) in aorta from nondiabetic (ND) compared to type 2 diabetic mice (DB, BKS. Read More

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http://dx.doi.org/10.1155/2012/398406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3546478PMC
May 2013
4 Reads

Animal models of diabetes mellitus for islet transplantation.

Exp Diabetes Res 2012 30;2012:256707. Epub 2012 Dec 30.

Division of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8574, Japan.

Due to current improvements in techniques for islet isolation and transplantation and protocols for immunosuppressants, islet transplantation has become an effective treatment for severe diabetes patients. Many diabetic animal models have contributed to such improvements. In this paper, we focus on 3 types of models with different mechanisms for inducing diabetes mellitus (DM): models induced by drugs including streptozotocin (STZ), pancreatomized models, and spontaneous models due to autoimmunity. Read More

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http://dx.doi.org/10.1155/2012/256707DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3546491PMC
May 2013
7 Reads

Noncoding RNAs.

Exp Diabetes Res 2012 29;2012:629249. Epub 2012 Dec 29.

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http://dx.doi.org/10.1155/2012/629249DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3544277PMC
May 2013
6 Reads

Prevalence and risk factors of prolonged QTc interval among Chinese patients with type 2 diabetes.

Exp Diabetes Res 2012 25;2012:234084. Epub 2012 Dec 25.

Diabetes Center, The 306th Hospital of PLA, Beijing 100101, China.

Objectives: The aim of this study was to evaluate the prevalence and the risk factors of prolonged QTc interval among Chinese patients with type 2 diabetes.

Methods: The retrospective study included 3156 outpatients from the Diabetes Centre, the 306th Hospital of PLA, during the period from September 2003 to June 2010. QT interval was measured manually in the 12-lead conventional electrocardiogram. Read More

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http://dx.doi.org/10.1155/2012/234084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3540769PMC
May 2013
6 Reads

Associations of common variants at APLN and hypertension in Chinese subjects with and without diabetes.

Exp Diabetes Res 2012 17;2012:917496. Epub 2012 Dec 17.

Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, 600 Yishan Road Shanghai, 200233, China.

Background: Apelin, the endogenous ligand for the APJ receptor, has a potent hypotensive effect via a nitric oxide-dependent mechanism in vivo. The aim of the study was to investigate the association between the common variants of apelin gene (APLN) and hypertension, which was reported recently in a Chinese Han population with and without diabetes.

Methods: Three single nucleotide polymorphisms (SNPs) on APLN were genotyped in 3156 diabetic patients and 3736 nondiabetic individuals. Read More

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http://dx.doi.org/10.1155/2012/917496DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3534217PMC
May 2013
23 Reads

Single diabetic QTL derived from OLETF rat is a sufficient agent for severe diabetic phenotype in combination with leptin-signaling deficiency.

Exp Diabetes Res 2012 5;2012:858121. Epub 2012 Dec 5.

Department of Life Science, Division of Natural Sciences, International Christian University, Mitaka, Tokyo 181-8585, Japan.

Obesity has been considered one of the leading causative agents for diseases such as type 2 diabetes, stroke, and heart attack. Due to their complex etiology, establishing a useful animal model is increasingly crucial for better molecular understanding of how obesity influences on disease development. OLETF rat is a spontaneous model of type 2 diabetes. Read More

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http://dx.doi.org/10.1155/2012/858121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3529458PMC
May 2013
5 Reads

Beneficial effects of aminoguanidine on skin flap survival in diabetic rats.

Exp Diabetes Res 2012 13;2012:721256. Epub 2012 Dec 13.

Department of Plastic Reconstructive and Aesthetic Surgery, Inonu University School of Medicine, 44380 Malatya, Turkey.

Random flaps in DM patients have poor reliability for wound coverage, and flap loss remains a complex challenge. The protective effects of aminoguanidine (AG) administration on the survival of dorsal random flaps and oxidative stress were studied in diabetic rats. Two months after the onset of DM, dorsal McFarlane flaps were raised. Read More

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http://dx.doi.org/10.1155/2012/721256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3532918PMC
May 2013
5 Reads

Correlation between blood activin levels and clinical parameters of type 2 diabetes.

Exp Diabetes Res 2012 16;2012:410579. Epub 2012 Dec 16.

Monash Institute of Medical Research, Monash University, Clayton, VIC 3168, Australia.

Aims: Activins A and B, and their binding protein, follistatin, regulate glucose metabolism and inflammation. Consequently, their role in type 2 diabetes (T2D) was examined.

Methods: Blood was taken from fasted participants (34 males; 58 females; 50-75 years) with diabetes or during an oral glucose tolerance test (OGTT). Read More

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http://dx.doi.org/10.1155/2012/410579DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3533484PMC
May 2013
6 Reads

Investigating endothelial activation and oxidative stress in relation to glycaemic control in a multiethnic population.

Exp Diabetes Res 2012 6;2012:386041. Epub 2012 Dec 6.

Department of Diabetes Research, University Hospitals of Leicester, NHS Trust, Leicester LE5 4PW, UK.

Aim: An exploration of ethnic differences in measures of oxidative stress and endothelial activation in relation to known cardiovascular risk factors within South Asians (SA) and White Europeans (WE) residing in the UK.

Methods: 202 participants within a UK multiethnic population provided biomedical and anthropometric data. Human urinary 2,3-dinor-8-iso-prostaglandin-F1α and plasma ICAM-1 were quantified as measures of oxidative stress and endothelial activation, respectively. Read More

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http://dx.doi.org/10.1155/2012/386041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3523138PMC
May 2013
4 Reads

Plasma plasminogen activator inhibitor-1 is associated with end-stage proliferative diabetic retinopathy in the Northern Chinese Han population.

Exp Diabetes Res 2012 14;2012:350852. Epub 2012 Oct 14.

Clinical College of Ophthalmology, Tianjin Medical University, Tianjin 300020, China.

Objective: To identify predictors of end-stage proliferative diabetic retinopathy (PDR) in a cohort of individuals with type 2 diabetes mellitus (T2DM) from the Northern Chinese Han population.

Methods: We investigated characteristics of 153 consecutive diabetic patients with end-stage PDR (62 males, 91 females), 123 consecutive PDR patients without end-stage PDR (48 males, 75 females), and 151 normal subjects (63 males, 88 females). Only one eye of each patient or healthy subject was included in this study. Read More

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http://dx.doi.org/10.1155/2012/350852DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518968PMC
May 2013
5 Reads

BDKRB2 +9/-9 polymorphism is associated with higher risk for diabetes mellitus in the Brazilian general population.

Exp Diabetes Res 2012 29;2012:480251. Epub 2012 Nov 29.

Laboratory of Genetics and Molecular Cardiology, Heart Institute-InCor, University of Sao Paulo Medical School, Avenida Dr. Enéas de Carvalho Aguiar, 44 Cerqueira César, 05403-000 São Paulo, SP, Brazil.

Some mechanisms have been proposed to explain the role of bradykinin on glucose homeostasis and some studies reported that the BDKRB2 +9/-9 polymorphism was associated to the transcriptional activity of the receptor. In this scenario, the main aim of this study was to evaluate the association of the BDKRB2 +9/-9 polymorphism with diabetes mellitus risk in the Brazilian general population. This study included 1,032 subjects of the general urban population. Read More

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http://dx.doi.org/10.1155/2012/480251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3517850PMC
May 2013
5 Reads

Increased inflammation in atherosclerotic lesions of diabetic Akita-LDLr⁻/⁻ mice compared to nondiabetic LDLr⁻/⁻ mice.

Exp Diabetes Res 2012 28;2012:176162. Epub 2012 Nov 28.

Department of Clinical Sciences Malmö, Skåne University Hospital, Lund University, CRC Entrance 72, 20502 Malmö, Sweden.

Background: Diabetes is associated with increased cardiovascular disease, but the underlying cellular and molecular mechanisms are poorly understood. One proposed mechanism is that diabetes aggravates atherosclerosis by enhancing plaque inflammation. The Akita mouse has recently been adopted as a relevant model for microvascular complications of diabetes. Read More

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http://www.hindawi.com/journals/jdr/2012/176162/
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http://dx.doi.org/10.1155/2012/176162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3515907PMC
May 2013
5 Reads

Impact of maternal diabetes on epigenetic modifications leading to diseases in the offspring.

Exp Diabetes Res 2012 22;2012:538474. Epub 2012 Nov 22.

2nd Department of Obstetrics and Gynecology, Aretaieion Hospital, University of Athens Medical School, 11528 Athens, Greece.

Gestational diabetes, occurring during the hyperglycemic period of pregnancy in maternal life, is a pathologic state that increases the incidence of complications in both mother and fetus. Offspring thus exposed to an adverse fetal and early postnatal environment may manifest increased susceptibility to a number of chronic diseases later in life. Compelling evidence for the role of epigenetic transmission in these complications has come from comparison of siblings born before and after the development of maternal diabetes, exposure to this intrauterine diabetic environment being shown to cause alterations in fetal growth patterns which predispose these infants to developing overweight and obesity later in life. Read More

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http://dx.doi.org/10.1155/2012/538474DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3512252PMC
May 2013
8 Reads

Adipocytokine levels in genetically high risk for type 2 diabetes in the Indian population: a cross-sectional study.

Exp Diabetes Res 2012 14;2012:386524. Epub 2012 Nov 14.

Department of Biochemistry, L.N. Medical College, Kolar Road, Bema Kunj, Bhopal 462042, India.

Introduction: In view of the noteworthy role of adipocytokines in the onset of insulin resistance and diabetes in gene-knockout-rat-model-cell-line studies we aimed to study the influence of genetic predisposition for diabetes on adipocytokine levels and their role in building insulin-resistance-like environment well before the onset of diabetes; thus a hypothesis can be drawn on their role in developing diabetes in high risk population.

Methods: Ages between 18 and 22 years were selected and divided into three groups. Group I (n = 81): control group with no family history of diabetes. Read More

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http://dx.doi.org/10.1155/2012/386524DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3505654PMC
May 2013
6 Reads

Dipeptidyl peptidase 4 inhibition may facilitate healing of chronic foot ulcers in patients with type 2 diabetes.

Exp Diabetes Res 2012 1;2012:892706. Epub 2012 Nov 1.

Department of Geriatrics and Metabolic Diseases, Second University of Naples, 80138 Naples, Italy.

The pathophysiology of chronic diabetic ulcers is complex and still incompletely understood, both micro- and macroangiopathy strongly contribute to the development and delayed healing of diabetic wounds, through an impaired tissue feeding and response to ischemia. With adequate treatment, some ulcers may last only weeks; however, many ulcers are difficult to treat and may last months, in certain cases years; 19-35% of ulcers are reported as nonhealing. As no efficient therapy is available, it is a high priority to develop new strategies for treatment of this devastating complication. Read More

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http://dx.doi.org/10.1155/2012/892706DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3503302PMC
May 2013
12 Reads

KU-32, a novel drug for diabetic neuropathy, is safe for human islets and improves in vitro insulin secretion and viability.

Exp Diabetes Res 2012 1;2012:671673. Epub 2012 Nov 1.

Department of Pharmacology and Toxicology, University of Kansas, 5064 Malott Hall, Lawrence, KS 66045, USA.

KU-32 is a novel, novobiocin-based Hsp90 inhibitor that protects against neuronal glucotoxicity and reverses multiple clinical indices of diabetic peripheral neuropathy in a rodent model. However, any drug with potential for treating diabetic complications must also have no adverse effects on the function of pancreatic islets. Thus, the goal of the current study was to assess the effect of KU-32 on the in vitro viability and function of human islets. Read More

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http://dx.doi.org/10.1155/2012/671673DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3503326PMC
May 2013
6 Reads

Blockade of renin angiotensin system increased resistance to STZ-induced diabetes in rats with long-term high-fat diet.

Exp Diabetes Res 2012 12;2012:618923. Epub 2012 Nov 12.

Department of Endocrinology, Zhongnan Hospital, Wuhan University, 169 Donghu Road, Wuhan 430071, China.

This study aimed to investigate whether rennin-angiotensin system (RAS) blockade through telmisartan would increase the resistance to streptozotocin- (STZ-) induced diabetes in insulin resistance rats. There were sixty Wistar rats that were divided into four groups: normal control (NC), high-fat diet (HF), high-fat diet plus STZ injection (HF+S), and high-fat diet plus STZ injection and telmisartan intervention (HF+S+T). Five rats were chosen randomly and respectively from groups NC and HF to undergo a hyperinsulinemic euglycemic clamp. Read More

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http://dx.doi.org/10.1155/2012/618923DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3503274PMC
May 2013
7 Reads

Long-term consequences for offspring of paternal diabetes and metabolic syndrome.

Exp Diabetes Res 2012 5;2012:684562. Epub 2012 Nov 5.

Department of Medicine and Nutrition, Guanajuato University, León, Mexico.

Background: Recent studies have reported an increase in the prevalence of obesity and metabolic syndrome in children and adolescents. However, few have focused how diabetes mellitus and metabolic syndrome together in parents can influence on obesity and metabolic disturbances in offspring.

Objective: To know the risk obesity and metabolic disturbance in children, adolescents, and young adults whose parents have diabetes mellitus and metabolic syndrome. Read More

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http://dx.doi.org/10.1155/2012/684562DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501830PMC
May 2013
6 Reads

Genetic variation in CYP17A1 is associated with arterial stiffness in diabetic subjects.

Exp Diabetes Res 2012 23;2012:827172. Epub 2012 Oct 23.

Department of Food and Nutrition, Chonnam National University, Gwangju, Republic of Korea.

Hypertension and arterial stiffness are associated with an increasing risk of diabetes and cardiovascular diseases. This study aimed to identify genetic variants affecting hypertension and arterial stiffness in diabetic subjects and to compare genetic associations with hypertension between prediabetic and diabetic subjects. A total of 1,069 participants (326 prediabetic and 743 diabetic subjects) were assessed to determine the genetic variants affecting hypertension by analyzing 52 SNPs previously reported to be associated with hypertension. Read More

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http://dx.doi.org/10.1155/2012/827172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3485973PMC
January 2013
4 Reads

Cardiovascular disease risk in the offspring of diabetic women: the impact of the intrauterine environment.

Exp Diabetes Res 2012 22;2012:565160. Epub 2012 Oct 22.

Pregnancy Research Centre, The Royal Women's Hospital, Parkville, VIC 3052, Australia.

The incidence of gestational diabetes is increasing worldwide, exposing large numbers of infants to hyperglycaemia whilst in utero. This exposure may have a long-term negative impact on the cardiovascular health of the offspring. Novel methods to assess cardiovascular status in the neonatal period are now available-including measuring arterial intima-media thickness and retinal photography. Read More

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http://dx.doi.org/10.1155/2012/565160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3485506PMC
January 2013
6 Reads

Influence of tumour necrosis factor alpha on the outcome of ischaemic postconditioning in the presence of obesity and diabetes.

Exp Diabetes Res 2012 17;2012:502654. Epub 2012 Oct 17.

Cardioprotection Group, Hatter Institute for Cardiovascular Research in Africa, Department of Medicine, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory, Cape Town 7925, South Africa.

Obesity and diabetes contribute to cardiovascular disease and alter cytokine profile. The cytokine, tumour necrosis factor alpha (TNFα), activates a protective signalling cascade during ischaemic postconditioning (IPostC). However, most successful clinical studies with IPostC have not included obese and/or diabetic patients. Read More

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http://dx.doi.org/10.1155/2012/502654DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3483678PMC
January 2013
6 Reads

Genetic dissection of complex genetic factor involved in NIDDM of OLETF rat.

Exp Diabetes Res 2012 15;2012:582546. Epub 2012 Oct 15.

Laboratory of Animal Genetics, Division of Life and Food Sciences, Graduate School of Science and Technology, Niigata University, Nishi-ku, Niigata 950-2181, Japan.

The Otsuka Long-Evans Tokushima Fatty (OLETF) rat is an animal model for obese-type, noninsulin-dependent diabetes mellitus (NIDDM) in humans. NIDDM in this rat model was shown to be regulated by multiple genes. We have identified 14 quantitative trait loci (QTLs) responsible for NIDDM (Nidd1-14/of) on chromosomes 1, 5, 7, 8, 9, 11, 12, 14, 16, and 17 by a whole genome search in 160 F2 progenies obtained by mating the OLETF and the F344 rats. Read More

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http://dx.doi.org/10.1155/2012/582546DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478749PMC
January 2013
4 Reads

Metformin stimulates FGF21 expression in primary hepatocytes.

Exp Diabetes Res 2012 15;2012:465282. Epub 2012 Oct 15.

Department of Pharmacology and Pharmacotherapy, University of Copenhagen, 2100 Copenhagen, Denmark.

Fibroblast growth factor 21 (FGF21) is a novel metabolic regulator of glucose and lipid metabolism; however, the exact mechanism of action and regulation of FGF21 is not fully understood. Metabolic status plays an important role in the regulation of FGF21, and we therefore examined whether metformin, an indirect AMPK-activator, regulates FGF21 expression in hepatocytes. FGF21 mRNA and protein expression were determined after incubation of primary cultured rat and human hepatocytes with metformin for 24 hours. Read More

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http://www.hindawi.com/journals/jdr/2012/465282/
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http://dx.doi.org/10.1155/2012/465282DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478742PMC
January 2013
6 Reads

Effect of ezetimibe on insulin secretion in db/db diabetic mice.

Exp Diabetes Res 2012 17;2012:420854. Epub 2012 Oct 17.

Department of Cardiology, School of Medicine, Nanjing University, Jinling Hospital, 305 East Zhongshan Road, Jiangsu Province, Nanjing 210002, China.

Objective: To investigate the effect of ezetimibe on the insulin secretion in db/db mice.

Methods: The db/db diabetic mice aged 8 weeks were randomly assigned into 2 groups and intragastrically treated with ezetimibe or placebo for 6 weeks. The age matched db/m mice served as controls. Read More

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http://dx.doi.org/10.1155/2012/420854DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3483710PMC
January 2013
5 Reads

Impact of insulin resistance on silent and ongoing myocardial damage in normal subjects: the Takahata study.

Exp Diabetes Res 2012 10;2012:815098. Epub 2012 Oct 10.

Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, 2-2-2 Iida-Nishi, Yamagata 990-9585, Japan.

Background: Insulin resistance (IR) is part of the metabolic syndrome (Mets) that develops after lifestyle changes and obesity. Although the association between Mets and myocardial injury is well known, the effect of IR on myocardial damage remains unclear.

Methods And Results: We studied 2200 normal subjects who participated in a community-based health check in the town of Takahata in northern Japan. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3474255PMC
January 2013
13 Reads

Aspects of inflammation and oxidative stress in pediatric obesity and type 1 diabetes: an overview of ten years of studies.

Exp Diabetes Res 2012 11;2012:683680. Epub 2012 Oct 11.

Insitute for Clinical and Translational Science, University of California, 843 Health Science Road, Irvine, CA 92697, USA.

Obesity and type 1 diabetes (T1DM) are the two most common conditions of altered metabolism in children and adolescents. In both, similar long-term cardiovascular complications are known to occur, mediated in large part by underlying inflammatory and oxidative processes whose biochemical details remain relatively unclear. Through a series of experiments in these patient populations, over the last decade our laboratory has clarified a number of key issues in this field. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3475317PMC
January 2013
6 Reads

Renal podocyte injury in a rat model of type 2 diabetes is prevented by metformin.

Exp Diabetes Res 2012 27;2012:210821. Epub 2012 Sep 27.

Traditional Korean Medicine (TKM) Based Herbal Drug Research Group, Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Yuseongdaero, Yuseong-gu, Daejeon, Republic of Korea.

Hyperglycemia promotes oxidative stress and hence generation of reactive oxygen species (ROS), which is known to play a crucial role in the pathogenesis of diabetic nephropathy. Metformin, an oral hypoglycemic drug, possesses antioxidant effects. The aim of this paper is to investigate the protective effects of metformin on the injury of renal podocytes in spontaneously diabetic Torii (SDT) rats, a new model for nonobese type 2 diabetes. Read More

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http://dx.doi.org/10.1155/2012/210821DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3465985PMC
January 2013
6 Reads

Haplotypes in the CRP gene associated with increased BMI and levels of CRP in subjects with type 2 diabetes or obesity from Southwestern Mexico.

Exp Diabetes Res 2012 25;2012:982683. Epub 2012 Sep 25.

Laboratorio de Enfermedades Crónico Degenerativas, Unidad Académica de Ciencias Químico Biológicas, Universidad Autónoma de Guerrero, 39070 Chilpancingo, GRO, Mexico.

Objective: We evaluated the association between four polymorphisms in the CRP gene with circulating levels of C-reactive protein (CRP), type 2 diabetes (T2D), obesity, and risk score of coronary heart disease.

Methods: We studied 402 individuals and classified them into four groups: healthy, obese, T2D obese, and T2D without obesity, from Guerrero, Southwestern Mexico. Blood levels of CRP, glucose, cholesterol, triglycerides, and leukocytes were measured. Read More

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http://dx.doi.org/10.1155/2012/982683DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3463182PMC
January 2013
11 Reads

Functional expression of TRPV4 channels in human collecting duct cells: implications for secondary hypertension in diabetic nephropathy.

Exp Diabetes Res 2012 20;2012:936518. Epub 2012 Sep 20.

School of Life Sciences, The University of Warwick, Coventry CV4 7AL, UK.

Background: The Vanilloid subfamily of transient receptor potential (TRPV) ion channels has been widely implicated in detecting osmotic and mechanical stress. In the current study, we examine the functional expression of TRPV4 channels in cell volume regulation in cells of the human collecting duct.

Methods: Western blot analysis, siRNA knockdown, and microfluorimetry were used to assess the expression and function of TRPV4 in mediating Ca²⁺-dependent mechanical stimulation within a novel system of the human collecting duct (HCD). Read More

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http://dx.doi.org/10.1155/2012/936518DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3461299PMC
January 2013
6 Reads

Circulating TGF-β1, glycation, and oxidation in children with diabetes mellitus type 1.

Exp Diabetes Res 2012 26;2012:510902. Epub 2012 Sep 26.

Institute of Medical Chemistry, Biochemistry and Clinical Biochemistry, Faculty of Medicine, Comenius University, Sasinkova 2, Bratislava 81108, Slovakia.

The present study investigates the relationship between diabetes metabolic control represented by levels of HbA1c, early glycation products-(fructosamine (FAM)), serum-advanced glycation end products (s-AGEs), lipoperoxidation products (LPO), advanced oxidation protein products (AOPP) and circulating TGF-β in young patients with DM1. The study group consisted of 79 patients with DM1 (8-18 years). 31 healthy children were used as control (1-16 years). Read More

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http://dx.doi.org/10.1155/2012/510902DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3463181PMC
January 2013
9 Reads

Nicotine exposure exacerbates development of cataracts in a type 1 diabetic rat model.

Exp Diabetes Res 2012 20;2012:349320. Epub 2012 Sep 20.

Department of Ophthalmology and Visual Sciences, University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA.

Diabetes and smoking are known risk factors for cataract development. In this study, we evaluated the effect of nicotine on the progression of cataracts in a type 1 diabetic rat model. Diabetes was induced in Sprague-Dawley rats by a single injection of 65 mg/kg streptozotocin. Read More

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http://dx.doi.org/10.1155/2012/349320DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3459283PMC
January 2013
32 Reads

Glibenclamide induces collagen IV catabolism in high glucose-stimulated mesangial cells.

Exp Diabetes Res 2012 12;2012:183535. Epub 2012 Sep 12.

Division of Nephrology and Hypertension, Department of Medicine, Henry Ford Hospital, Detroit, MI 48202, USA.

We have shown the full prevention of mesangial expansion in insulin-deficient diabetic rats by treatment with clinically-relevant dosages of glibenclamide (Glib). Studies in mesangial cells (MCs) also demonstrated reduction in the high glucose (HG)-induced accumulation of collagens, proposing that this was due to increased catabolism. In the present study, we investigated the signaling pathways that may be implicated in Glib action. Read More

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http://dx.doi.org/10.1155/2012/183535DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447387PMC
January 2013
9 Reads

Simple cystatin C formula for estimation of glomerular filtration rate in overweight patients with diabetes mellitus type 2 and chronic kidney disease.

Exp Diabetes Res 2012 12;2012:179849. Epub 2012 Sep 12.

Department of Nephrology, Clinic of Internal Medicine, University Medical Center Maribor, 2000 Maribor, Slovenia.

In clinical practice the glomerular filtration rate (GFR) is estimated from serum creatinine-based equations like the Cockcroft-Gault formula (C&G) and Modification of Diet in Renal Disease formula (MDRD). Recently, serum cystatin C-based equations, the newer creatinine formula (The Chronic Kidney Disease Epidemiology Collaboration formula (CKD-EPI)), and equation that use both serum creatinine and cystatin C (CKD-EPI creatinine & cystatin formula) were proposed as new GFR markers. Present study compares serum creatinine-based equations, combined (including both serum creatinine and cystatin C) equation, and serum simple cystatin C formula (100/serum cystatin C) against 51CrEDTA clearance in 113 adult overweight Caucasians with diabetes mellitus type 2 (DM2) and chronic kidney disease (CKD). Read More

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http://dx.doi.org/10.1155/2012/179849DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447360PMC
January 2013
16 Reads
2 Citations
3.540 Impact Factor

Oxytocin and psychological factors affecting type 2 diabetes mellitus.

Exp Diabetes Res 2012 10;2012:560864. Epub 2012 Sep 10.

1st Department of Psychiatry, Eginition Hospital, Athens University Medical School, 11528 Athens, Greece.

Background: The aim of this study was to investigate the association of oxytocin with trait and state psychological factors in type 2 diabetic patients.

Methods: OXT and psychological variables were analyzed from 86 controlled diabetic patients (glycosylated haemoglobin A1c (HbA1c) < 7%) from 45 uncontrolled diabetic patients (HbA1c ≥ 7). Psychological characteristics were assessed with the Eysenck Personality Questionnaire (EPQ), while state psychological characteristics were measured with the Symptom Checklist 90-R (SCL 90-R). Read More

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http://dx.doi.org/10.1155/2012/560864DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3444905PMC
January 2013
5 Reads

Dysregulation of Dicer1 in beta cells impairs islet architecture and glucose metabolism.

Exp Diabetes Res 2012 6;2012:470302. Epub 2012 Sep 6.

Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel.

microRNAs (miRNAs) play important roles in pancreas development and in regulation of insulin expression in the adult. Here we show that loss of miRNAs activity in beta-cells during embryonic development results in lower beta-cell mass and in impaired glucose tolerance. Dicer1-null cells initially constitute a significant portion of the total beta-cell population. Read More

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http://dx.doi.org/10.1155/2012/470302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3443614PMC
January 2013
14 Reads

Propyl gallate plays a nephroprotective role in early stage of diabetic nephropathy associated with suppression of glomerular endothelial cell proliferation and angiogenesis.

Exp Diabetes Res 2012 4;2012:209567. Epub 2012 Sep 4.

Department of Nephrology, Renmin Hospital, Hubei University of Medicine, Hubei, Shiyan 442000, China.

There is growing evidence suggesting that glomerular endothelial cell proliferation and angiogenesis may be responsible for the pathophysiological events in the early stage of diabetic nephropathy. This study was designed to investigate the factors related to glomerular endothelial cell proliferation and glomerular angiogenesis and assess the effect of propyl gallate on preventing these disorders in diabetic rats. We found that glomerular hypertrophy, glomerular mesangial matrix expansion, and albuminuria were significantly increased in DN rats. Read More

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http://dx.doi.org/10.1155/2012/209567DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3439983PMC
January 2013
6 Reads

Vascular disease in diabetic women: Why do they miss the female protection?

Exp Diabetes Res 2012 3;2012:570598. Epub 2012 Sep 3.

Experimental Cardiology Division, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) and Institut Clínic de Tòrax, C/Casanova 143 Laboratory, IDIBAPS 404, Hospital Clinic, 08036 Barcelona, Spain.

Gender plays a pivotal role in the onset as well as in the progression of the cardiovascular disease with a higher morbidity and mortality being detected in men with respect to women. Type 2 Diabetes Mellitus (T2DM) may reduce gender-related differences in the prevalence of cardiovascular disease by fading the vascular protective effects afforded by estrogen in females. This article will discuss the role of sex and sex hormones on the incidence and mechanisms involved in vascular dysfunction associated to T2DM, which might explain why women with T2DM lack the vascular protection. Read More

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http://dx.doi.org/10.1155/2012/570598DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3438753PMC
January 2013
6 Reads

Associations of existing diabetes, gestational diabetes, and glycosuria with offspring IQ and educational attainment: the Avon Longitudinal Study of Parents and Children.

Exp Diabetes Res 2012 13;2012:963735. Epub 2012 Aug 13.

MRC Centre for Causal Analyses in Translational Epidemiology, School of Social & Community Medicine, University of Bristol, Bristol BS8 2BN, UK.

Introduction: Results from studies examining associations of maternal diabetes in pregnancy with offspring cognitive outcomes have been inconclusive.

Methods: We used data from the Avon Longitudinal Study of Parents and Children, a UK prospective pregnancy cohort. Outcomes were School Entry Assessment (SEA) scores (age 4, N = 6, 032) and WISC-III IQ (age 8, N = 5, 282-5,307) and General Certificate of Secondary Education (GCSE) results (age 16, N = 7, 615). Read More

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http://dx.doi.org/10.1155/2012/963735DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3425081PMC
December 2012
4 Reads

The common C49620T polymorphism in the sulfonylurea receptor gene SUR1 (ABCC8) in patients with gestational diabetes and subsequent glucose metabolism abnormalities.

Exp Diabetes Res 2012 15;2012:712617. Epub 2012 Aug 15.

Department of Diabetology and Internal Diseases, Pomeranian Medical University, Szczecin, Poland.

Aim: The aim of this study is to investigate the relationship between the common C49620T polymorphism in the sulfonylurea receptor (SUR1) gene and glucose metabolism, β-cell secretory function and insulin resistance in women with a history of gestational diabetes (GDM).

Material And Methods: Study group included 199 women, diagnosed GDM within the last 5-12 years and control group of comparable 50 women in whom GDM was excluded during pregnancy. Blood glucose and insulin levels were measured during oral glucose tolerance test. Read More

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http://www.hindawi.com/journals/jdr/2012/712617/
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http://dx.doi.org/10.1155/2012/712617DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3426201PMC
December 2012
11 Reads

Persistence of inflammatory response to intense exercise in diabetic rats.

Exp Diabetes Res 2012 13;2012:213986. Epub 2012 Aug 13.

Institute of Physical Activity and Sport Sciences, Cruzeiro do Sul University, Rua Galvão Bueno 868, 13° andar, 01506-000 São Paulo, Brazil.

In this study we evaluated the onset and resolution of inflammation in control and streptozotocin-induced diabetic rats subjected to a single session of intense exercise. The following measurements were carried out prior to, immediately after, and 2 and 24 hours after exercise: plasma levels of proinflammatory cytokines (TNF-α, IL-1β, IL-6, CINC-2α/β, MIP-3α, and IL-6), immunoglobulins (IgA and IgM), acute phase proteins (CRP and C3), and creatine kinase (CK) activity. We also examined the occurrence of macrophage death by measurements of macrophages necrosis (loss of membrane integrity) and DNA fragmentation. Read More

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http://dx.doi.org/10.1155/2012/213986DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3424703PMC
December 2012
7 Reads

Impact of diabetes and hyperglycemia on survival in advanced breast cancer patients.

Exp Diabetes Res 2012 31;2012:732027. Epub 2012 Jul 31.

Clínica de Cáncer de Mama, Instituto Nacional de Cancerología, 14080 México, DF, Mexico.

Purpose: We examined the impact of diabetes and hyperglycemia on cancer-specific survival of patients with metastatic or recurrent breast cancer (BC).

Methods: We performed a retrospective analysis of 265 patients with advanced BC receiving palliative chemotherapy. BC-specific mortality was compared for diabetic and nondiabetic patients as well as for patients that presented hyperglycemia during treatment. Read More

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http://dx.doi.org/10.1155/2012/732027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419428PMC
December 2012
13 Reads

Antioxidant sol-gel improves cutaneous wound healing in streptozotocin-induced diabetic rats.

Exp Diabetes Res 2012 7;2012:504693. Epub 2012 Aug 7.

Graduate Institute of Applied Science and Technology, National Taiwan University of Science and Technology, Taipei 106, Taiwan.

We examined the effects of vitamin C in Pluronic F127 on diabetic wound healing. Full-thickness excision skin wounds were made in normal and diabetic Wistar rats to evaluate the effect of saline, saline plus vitamin C (antioxidant sol), Pluronic F127, or Pluronic F127 plus vitamin C (antioxidant sol-gel). The rate of wound contraction, the levels of epidermal and dermal maturation, collagen synthesis, and apoptosis production in the wound tissue were determined. Read More

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http://dx.doi.org/10.1155/2012/504693DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3420222PMC
December 2012
12 Reads

Efficient differentiation of mouse embryonic stem cells into insulin-producing cells.

Exp Diabetes Res 2012 5;2012:201295. Epub 2012 Aug 5.

Pharmacognosy Lab, Herbal Medicinal Product Technology Division, Industrial Technology Research Institute, Hsinchu 30011, Taiwan.

Embryonic stem (ES) cells are a potential source of a variety of differentiated cells for cell therapy, drug discovery, and toxicology screening. Here, we present an efficacy strategy for the differentiation of mouse ES cells into insulin-producing cells (IPCs) by a two-step differentiation protocol comprising of (i) the formation of definitive endoderm in monolayer culture by activin A, and (ii) this monolayer endoderm being induced to differentiate into IPCs by nicotinamide, insulin, and laminin. Differentiated cells can be obtained within approximately 7 days. Read More

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http://dx.doi.org/10.1155/2012/201295DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3420137PMC
December 2012
5 Reads

Obesity and appetite control.

Exp Diabetes Res 2012 1;2012:824305. Epub 2012 Aug 1.

Section of Investigative Medicine, Imperial College London, Commonwealth Building, Du Cane Road, London W12 0NN, UK.

Obesity is one of the major challenges to human health worldwide; however, there are currently no effective pharmacological interventions for obesity. Recent studies have improved our understanding of energy homeostasis by identifying sophisticated neurohumoral networks which convey signals between the brain and gut in order to control food intake. The hypothalamus is a key region which possesses reciprocal connections between the higher cortical centres such as reward-related limbic pathways, and the brainstem. Read More

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http://dx.doi.org/10.1155/2012/824305DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3415214PMC
December 2012
7 Reads

Effect of exercise on kidney function, oxidative stress, and inflammation in type 2 diabetic KK-A(y) mice.

Exp Diabetes Res 2012 26;2012:702948. Epub 2012 Jul 26.

Division of Nephrology, Department of Internal Medicine, Juntendo University Faculty of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.

Exercise is recommended for the management of type 2 diabetes, but its effects on diabetic nephropathy (DN) are still unknown. We hypothesized that appropriate exercise improves early DN via attenuation of inflammation and oxidative damage. Type 2 diabetic KK-A(y) mice, a spontaneous DN model, underwent two different kinds of exercise (i. Read More

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http://dx.doi.org/10.1155/2012/702948DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3412110PMC
December 2012
4 Reads