3,694 results match your criteria Experimental Dermatology[Journal]


Expression and biological functions of the CCL5-CCR5 axis in oral lichen planus.

Exp Dermatol 2019 Apr 21. Epub 2019 Apr 21.

Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, Jiangsu, China.

Oral lichen planus (OLP) is a chronic inflammatory oral mucosal disorder with T cell-mediated immunological pathogenesis. C-C motif chemokine ligand 5 (CCL5) and its receptor C-C motif chemokine receptor 5 (CCR5) play important roles in the activation and recruitment of T cells. This study sought to explore the expression and biological functions of the CCL5-CCR5 axis in OLP. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/exd.13946
Publisher Site
http://dx.doi.org/10.1111/exd.13946DOI Listing
April 2019
1 Read

Particulate Matter Induces Proinflammatory Cytokines via Phosphorylation of p38 MAPK Possibly Leading to Dermal Inflammaging.

Exp Dermatol 2019 Apr 18. Epub 2019 Apr 18.

Department of Dermatology, Chung-Ang University College of Medicine, Seoul, Korea.

Particulate matter (PM) is known to have harmful effects on human health. Epidemiological studies have suggested that PM exposure is related to skin diseases and extrinsic skin aging. However, the mechanisms by which PM affects skin are unclear. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/exd.13943DOI Listing

Malassezia-derived aryl hydrocarbon receptor ligands enhance the CCL20/ Th17/soluble CD163 pathogenic axis in extra-mammary Paget's disease.

Exp Dermatol 2019 Apr 18. Epub 2019 Apr 18.

Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.

Malassezia yeast play a role in the pathogenesis of chronic dermatitis, especially in apocrine areas, by polarizing the local immunologic background to a Th2/Th17 state through aryl hydrocarbon receptor (AhR)-dependent pathways. Extra-mammary Paget's disease (EMPD) is an adenocarcinoma of apocrine origin, and except for cases associated with Malassezia yeast and their metabolites, the lesions typically develop in areas not exposed to environmental material. The purpose of this study was to investigate 1) the immunomodulatory effects of Malassezia metabolites on normal human keratinocytes (NHKCs), focusing on interleukin (IL)-17 and related cytokines/chemokines (IL-23, IL-36γ, CCL20), 2) the expression of these factors in lesion-affected skin in EMPD, and 3) the activation of tumor-associated macrophages (TAMs) by these factors. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/exd.13944DOI Listing

A novel player in the field: Merkel disk in touch, itch, and pain.

Exp Dermatol 2019 Apr 18. Epub 2019 Apr 18.

Department of Anesthesiology, The Center for the Study of Itch, Washington University School of Medicine, St. Louis, MO, 63110, United States.

Mammalian skin, comprising both hairy and glabrous skin, is innervated by various types of low-threshold mechanoreceptors (LTMRs), which renders skin into a mechanosensitive organ [1]. Based on the degree of axonal myelination and conduction velocity, LTMRs are further divided into C-, Aδ- and Aβ-LTMRs. Electrophysiological recordings from those LTMRs have revealed unique action potential firing patterns upon discriminative mechanical stimuli. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/exd.13945
Publisher Site
http://dx.doi.org/10.1111/exd.13945DOI Listing
April 2019
1 Read

Platelets are important for the development of immune tolerance: possible involvement of TGF-β in the mechanism.

Exp Dermatol 2019 Apr 16. Epub 2019 Apr 16.

Department of Dermatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, 602-8566, Japan.

Platelets have diverse roles in immune processes in addition to their key functions in hemostasis and thrombosis. Some studies imply that platelets may be possibly related to the immune tolerance induction. However, the role of platelets in the development of immune tolerance is not fully understood. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/exd.13940DOI Listing
April 2019
1 Read

Why does stress aggravate itch? A possible role of the amygdala.

Exp Dermatol 2019 Apr 16. Epub 2019 Apr 16.

University of Miami, Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery, Miami Itch Center, 1600 NW 10th Ave RMSB2063, Miami, FL, 33136, USA.

Stress is the exacerbating factor of itch across patients with chronic itch due to different origins. However, the precise mechanisms behind stress-induced exacerbation of itch remain unknown. Chronic stress induces hyperexcitability of the amygdala, the center of emotional processing. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/exd.13941
Publisher Site
http://dx.doi.org/10.1111/exd.13941DOI Listing
April 2019
1 Read

Translational drug discovery and development with the use of tissue-relevant biomarkers: towards more physiological relevance and better prediction of clinical efficacy.

Exp Dermatol 2019 Apr 16. Epub 2019 Apr 16.

Sanofi, Global Head of Immunology Therapeutic Research Area, 640 Memorial Drive, Cambridge, MA, 02139, USA.

Due to the clinical development of drugs such as secukinumab, ustekinumab and dupilumab, major changes have been achieved in the treatment of patients diagnosed with psoriasis and atopic dermatitis. In academia and the pharmaceutical industry, research is increasingly moving towards the development of bi-specific antibodies and multi-specific nanobodies, as there is a compelling need for new treatment modalities for patients suffering from auto-immune or malignant disease. The purpose of this review is to discuss aspects of translational drug development with a particular emphasis on indications such as psoriasis and atopic dermatitis. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/exd.13942
Publisher Site
http://dx.doi.org/10.1111/exd.13942DOI Listing
April 2019
3 Reads

Melanosome maturation proteins Oca2, Mitfa and Vps11 are differentially required for cisplatin resistance in zebrafish melanocytes.

Exp Dermatol 2019 Apr 11. Epub 2019 Apr 11.

School of Molecular Biosciences, Washington State University, Vancouver, Vancouver, WA, 98686.

Melanoma is the deadliest form of skin cancer, partially due to its inherent resistance to therapy. Here, we test in live larvae the hypothesis that mature melanosomes contribute to resistance to chemotherapeutic drug, cisplatin, via drug sequestration. We also compare three melanosome biogenesis proteins - microphthalmia-associated transcription factor (Mitfa), vacuolar protein sorting 11 (Vps11) and oculocutaneous albinism 2 (Oca2) to determine their respective contributions to chemoresistance. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/exd.13937DOI Listing
April 2019
1 Read

The role of the microbiome in scalp hair follicle biology and disease.

Exp Dermatol 2019 Apr 11. Epub 2019 Apr 11.

Clinical Research Center for Hair and Skin Science, Department of Dermatology and Allergy, Charité-Universitaetsmedizin Berlin corporate member of Freie Universitaet Berlin, Humboldt-Universitaet zu Berlin and Berlin Institute of Health, Germany.

The skin surface microbiome and its role in skin diseases have received increasing attention over the past years. Beyond, there is evidence for a continuous exchange with the cutaneous immune system in healthy skin, where hair follicles provide unique anatomical niches. Especially scalp hair follicles form large tubular invaginations, which extend deeply into the skin and harbor a variety of microorganisms. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/exd.13935DOI Listing
April 2019
5 Reads

Salicylic acid treats acne vulgaris by suppressing AMPK/SREBP1 pathway in sebocytes.

Exp Dermatol 2019 Apr 11. Epub 2019 Apr 11.

Department of Dermatology, West China Hospital, Sichuan University, Chengdu, 610041, P. R. China.

Acne vulgaris is a prevalent cutaneous disease characterized by a multifactorial pathogenic process including hyperseborrhea, inflammation, over-keratinization of follicular keratinocytes as well as Propionibacterium acnes (P. acnes) overgrowth. Salicylic acid (SA), a beta-hydroxy acid, is frequently used in the treatment of acne. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/exd.13934DOI Listing
April 2019
3 Reads

Update on Protease Activated Receptor 2 in cutaneous barrier, differentiation, tumorigenesis, pigmentation, and role in related dermatologic diseases.

Exp Dermatol 2019 Apr 11. Epub 2019 Apr 11.

Department of Dermatology, College of Medicine, University of Florida, Gainesville, FL, USA.

Protease activated receptor 2 (PAR2) is a transmembrane receptor expressed by multiple tissues, including skin, with rapidly expanding knowledge regarding its roles. In the skin, PAR2 has extensively documented effects in promoting Th2-inflammation and pruritus; and its role in atopic dermatitis continues to be thoroughly studied. Numerous new investigations have shown a more complex range of activities potentially related to dermatologic diseases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/exd.13936DOI Listing
April 2019
2 Reads

Characterization of circadian human facial surface lipid composition.

Exp Dermatol 2019 Apr 10. Epub 2019 Apr 10.

Fu Xing Hospital, Capital Medical University, Beijing, China.

Background: The circadian rhythm is an endogenous clock that governs a wide range of physiological functions. In the skin, rhythmic changes in skin barrier function have been investigated at the physiological level; however, few studies at the molecular level have been reported. Additionally, there is no study on lipidomic profile variations of skin surface lipid (SSL), which could potentially explain the rhythmic changes in skin status. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/exd.13933DOI Listing
April 2019
1 Read
3.762 Impact Factor

Understanding Skin Morphogenesis Across Developmental, Regenerative and Evolutionary Levels.

Exp Dermatol 2019 Apr 5. Epub 2019 Apr 5.

Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA.

Morphogenesis produces anatomically elaborate and functionally diverse skin that is well adapted to dynamically interact with a complex and changing external environment. Understanding the principles and the driving forces of morphogenesis is fundamental for developing deeper insights into the causes and the mechanisms of skin pathologies. For instance, visible skin lesion patterns provide an "open book" to learn and understand many dermatological and systemic diseases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/exd.13932DOI Listing
April 2019
1 Read

Hypothesis: Wound-induced TLR3 activation stimulates endogenous retinoic acid synthesis and signaling during regeneration.

Exp Dermatol 2019 Mar 29. Epub 2019 Mar 29.

Department of Dermatology, Johns Hopkins School of Medicine, Baltimore, MD, 21287.

Although the mechanism is unclear, it has been shown that genetically normal adult mice with a large wound form de novo morphogenesis of hair follicles in Wound Induced Hair Neogenesis (WIHN)(1). We focused on how tissues recognize damage signals and identified that double stranded RNA (dsRNA)-mediated toll like receptor 3 (TLR3) activation stimulates WIHN. Here we propose a hypothesis that TLR3 stimulates retinoic acid synthesis and signaling to allow for regeneration, suggesting that common clinical methods of facial rejuvenation in human subjects through damage (such as lasers or dermabrasion) and the use of topical retinoids reflect the same biologic pathway. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/exd.13931DOI Listing

Exogenous hydrogen sulfide supplement accelerates skin wound healing via oxidative stress inhibition and vascular endothelial growth factor enhancement.

Exp Dermatol 2019 Mar 29. Epub 2019 Mar 29.

Department of Dermatology, Affiliated Hospital of Nantong University, Nantong, China.

Hydrogen sulfide (H S) is an important gasotransmitter with several physiological functions. However, the roles and the detailed mechanisms of H S on skin wound healing are not known well. In the present study, 129S1/SvImJ mice were intraperitoneally injected with NaHS (50 μmol/kg/d) for 2 weeks. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/exd.13930DOI Listing
March 2019
5 Reads

Proceeding report of the Third Symposium on Hidradenitis Suppurativa Advances (SHSA) 2018.

Exp Dermatol 2019 Mar 29. Epub 2019 Mar 29.

Department of Medicine, Division of Dermatology, University of Toronto, Toronto, ON, Canada.

The 3 Annual Symposium on Hidradenitis Suppurativa Advances (SHSA) took place on October 12-14, 2018 at the Women's College Hospital in Toronto, Ontario, Canada. This symposium was a joint meeting of the Hidradenitis Suppurativa Foundation (HSF) founded in the USA, and the Canadian Hidradenitis Suppurativa Foundation (CHSF). This cross-disciplinary meeting with experts from around the world was an opportunity to discuss the most recent advances in the study of hidradenitis suppurativa pathogenesis, epidemiology, classification, scoring systems, radiologic diagnosis, treatment approaches, and psychologic assessment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/exd.13928DOI Listing
March 2019
1 Read

Downregulation of TUG1 promotes melanogenesis and UVB-induced melanogenesis.

Exp Dermatol 2019 Mar 29. Epub 2019 Mar 29.

Department of Dermatology, Third Xiangya Hospital of Central South University, Changsha, Hunan, 410013, P.R. China.

Studies have revealed that taurine upregulated gene 1 (TUG1), an important member of the long non-coding RNA family, is involved in the regulation of cell growth, tumourigenesis and invasion, insulin secretion and so on. However, its role in melanogenesis has not been explored. This study attempts to explore the effects of TUG1 on melanogenesis and its regulatory mechanisms. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/exd.13929DOI Listing
March 2019
1 Read

Exosomes derived from human dermal papilla cells promote hair growth in cultured human hair follicles and augment the hair-inductive capacity of cultured dermal papilla spheres.

Exp Dermatol 2019 Mar 29. Epub 2019 Mar 29.

Department of Immunology, School of Medicine, Kyungpook National University, Daegu, Korea.

Dermal papillae (DP) play key roles in hair growth and regeneration by regulating follicular cell activity. Owing to the established roles of exosomes (Exos) in the regulation of cell functions, we investigated whether DP-derived Exos, especially those from three-dimensional (3D)-cultured DP cells, affect hair growth, cycling and regeneration. Exos derived from 3D DP (3D DP-Exos) promoted the proliferation of DP cells and outer root sheath (ORS) cells and increased the expression of growth factors (IGF-1, KGF and HGF) in DP cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/exd.13927DOI Listing
March 2019
3.762 Impact Factor

Genome-wide association study of psoriasis in an Egyptian population.

Exp Dermatol 2019 Mar 28. Epub 2019 Mar 28.

Lübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany.

Psoriasis is a chronic inflammatory disorder of the skin, with genetic factors reportedly involved in the disease pathogenesis. Numerous studies reported psoriasis candidate genes. However, these tend to involve mostly the European and Asian populations. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/exd.13926DOI Listing

Hair growth control by innate immunocytes: Perifollicular Macrophages revisited.

Exp Dermatol 2019 Mar 28. Epub 2019 Mar 28.

Centre for Dermatology Research, University of Manchester, and the NIHR Manchester Biomedical Research Centre, Manchester, UK.

The role of innate immunocytes such as mast cells, γδ T cells, NK cells and macrophages (MACs) in hair growth control under physiological and pathological conditions has recently begun to be re-explored. Here, we revisit the role of resident perifollicular Macrophages (pfMACs) located in the hair follicle (HF) mesenchyme (CTS). Substantial, stringently timed fluctuations in the number and localization of pfMACs were first observed long ago during murine HF morphogenesis and cycling. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/exd.13922DOI Listing

Injury modifies the fate of hair follicle dermal stem cell progeny in a hair-cycle dependent manner.

Exp Dermatol 2019 Mar 28. Epub 2019 Mar 28.

Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary.

The dermal papilla (DP) is one of two principal mesenchymal compartments of the hair follicle (HF). We previously reported that a population of HF dermal stem cells (hfDSCs) function to regenerate the dermal sheath (DS), but intriguingly also contribute new cells to the adult DP at the onset of anagen hair growth to maintain normal cycling of HFs and support the production of large hair fibers. Here, we asked whether injury altered the behavior of hfDSCs and their progeny in order to support wound-induced hair growth (WIHG) and if the response was modulated by hair cycle stage. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/exd.13924DOI Listing

STAT3 Signaling Pathway is Implicated in Keloid Pathogenesis by Preliminary Transcriptome and Open Chromatin Analyses.

Exp Dermatol 2019 Mar 27. Epub 2019 Mar 27.

The Saban Research Institute of Children's Hospital Los Angeles, Los Angeles, CA, USA.

Keloids are wounding-induced fibroproliferative human tumor-like skin scars of complex genetic makeup and poorly defined pathogenesis. To reveal dynamic epigenetic and transcriptome changes of keloid fibroblasts, we performed RNA-seq and ATAC-seq analysis on an early passage keloid fibroblast cell strain and its paired normal control fibroblasts. This keloid strain produced keloid-like scars in a plasma clot-based skin equivalent humanized keloid animal model. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/exd.13923DOI Listing
March 2019
3.762 Impact Factor

Human stratum corneum proteomics reveals cross-linking of a broad spectrum of proteins in cornified envelopes.

Exp Dermatol 2019 Mar 27. Epub 2019 Mar 27.

Department of Environmental Toxicology, University of California, Davis, CA.

Defects in keratinocyte transglutaminase (TGM1), resulting in an improper protein scaffold for deposition of the lipid barrier, comprise a major source of autosomal recessive congenital ichthyosis. For that reason, the composition and formation of the cornified (cross-linked) protein envelope of the epidermis have been of considerable interest. Since the isopeptide cross-linked protein components are not individually isolable once incorporated, purified envelopes were analyzed by mass spectrometry after trypsin digestion. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/exd.13925DOI Listing

Efficacy of a rhamnolipid biosurfactant to inhibit Trichophyton rubrum in vitro and in a mice model of dermatophytosis.

Exp Dermatol 2019 Mar 25. Epub 2019 Mar 25.

Environmental Biotechnology Laboratory, Resource Management and Environment Section, Life Sciences Division, Institute of Advanced Study in Science and Technology Vigyan Path, Paschim Boragaon, Garchuk, Guwahati, Assam, India.

Dermatophytic infections caused by Trichophyton rubrum is the most prevalent superficial mycoses worldwide. The present study was aimed at evaluating the anti-dermatophytic effect of a rhamnolipid biosurfactant (RL) produced by Pseudomonas aeruginosa SS14 (GenBank Accession no. KC866140) against T. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/exd.13921
Publisher Site
http://dx.doi.org/10.1111/exd.13921DOI Listing
March 2019
2 Reads

A potential link between desmoglein 3 and epidermal growth factor receptor in oral squamous cell carcinoma and its effect on cetuximab treatment efficacy.

Exp Dermatol 2019 Mar 25. Epub 2019 Mar 25.

Department of Dermatology, Tokyo Dental College Ichikawa General Hospital, 5-11-13 Sugano, Ichikawa-shi, 272-8513, Chiba, Japan.

Desmoglein (DSG) 3 is overexpressed in oral squamous cell carcinoma (OSCC). Epidermal growth factor receptor (EGFR) inhibitor cetuximab is widely used for OSCC treatment. Several evidences suggest a correlation between DSG3 and EGFR in epidermal keratinocytes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/exd.13920DOI Listing
March 2019
1 Read

Folliculitis decalvans is characterized by a persistent, abnormal subepidermal microbiota.

Exp Dermatol 2019 Mar 25. Epub 2019 Mar 25.

Centre Sabouraud, Hôpital Saint-Louis, Paris, France.

Folliculitis decalvans (FD) is a chronic inflammatory disease of unknown aetiology. Although Staphylococcus aureus, frequently found on lesional skin, is thought to play a causal role, the importance of its involvement remains controversial. To examine the role of S. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/exd.13916
Publisher Site
http://dx.doi.org/10.1111/exd.13916DOI Listing
March 2019
4 Reads

Dead Sea minerals: new findings on skin and the biology beyond.

Exp Dermatol 2019 Mar 23. Epub 2019 Mar 23.

Ahava Dead Sea Laboratories, Airport city, Israel.

Background: Therapeutic effects of Dead Sea (DS) minerals are well established, and their unique combination is analyzed and reported. DS water (DSW) is a key source for DS minerals and various studies report the capability of DSW to alleviate symptoms of different skin disorders and to contribute to skin maintenance. However, the biological mechanisms beyond reported effects are not fully understood yet. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/exd.13918DOI Listing

Matrix remodeling and MMP expression/activation is associated with hidradenitis suppurativa skin inflammation.

Exp Dermatol 2019 Mar 23. Epub 2019 Mar 23.

EA 7509 IRMAIC, UFR medicine, University of Champagne-ArdenneReims, France.

Hidradenitis suppurativa/acne inversa (HS) is a chronic, inflammatory, recurrent, debilitating skin disease of the hair follicle, associated with considerable tissue remodeling. Although abnormal cytokines expression was detected both in perilesional and in uninvolved skin, up to now there is no model allowing a better understanding of the implicit inflammatory mechanisms in HS. The aim of this study was to investigate the inflammatory response in HS skin by mean of an ex vivo model culture. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/exd.13919
Publisher Site
http://dx.doi.org/10.1111/exd.13919DOI Listing
March 2019
7 Reads

Imiquimod-induced skin inflammation is relieved by knockdown of sodium channel Na.

Exp Dermatol 2019 Mar 23. Epub 2019 Mar 23.

Laboratory for Tissue Repair and Regenerative Surgery, Department of Surgery/ Plastic Surgery Division, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA.

Na is an atypical sodium channel that mediates inflammatory pathways in pathological conditions of the skin. In this study, we developed a skin inflammation model in the rabbit ear through application of imiquimod (IMQ). Knockdown of Na using RNAi attenuated IMQ-induced skin inflammation, including skin erythema, scaling, and papule formation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/exd.13917DOI Listing

An Updated Classification of Hair Follicle Morphogenesis.

Exp Dermatol 2019 Mar 19. Epub 2019 Mar 19.

Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1020, New York, NY, 10029, USA.

Hair follicle formation in developing embryonic skin requires stepwise signaling between the epithelial epidermis and mesenchymal dermis, and their specialized derivatives, the placode/germ/peg and dermal condensate/papilla, respectively. Classically, distinct stages of hair follicle morphogenesis have been defined, in the mouse model, based on 1) changes in cell morphology and aggregation, 2) expression of few known molecular markers, 3) the extent of follicle downgrowth, and 4) the presence of differentiating cell types. Refined genetic strategies and recent emerging technologies, such as live imaging and transcriptome analyses of isolated cell populations or single cells, have enabled a closer dissection of the signaling requirements at different stages of hair follicle formation, particularly early on. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/exd.13913
Publisher Site
http://dx.doi.org/10.1111/exd.13913DOI Listing
March 2019
5 Reads

Influence of functional variants Asp312Asn and Lys751Gln of Xeroderma Pigmentosum Group D (XPD) and Glutathione S-transferase Mu 1 (GSTM1) and Theta 1 (GSTT1) genes on cutaneous melanoma susceptibility and prognosis.

Exp Dermatol 2019 Mar 18. Epub 2019 Mar 18.

Department of Internal Medicine, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.

We aimed to evaluate whether variants in repair (XPD Asp312Asn, XPD Lys751Gln) and detoxification (GSTM1, GSTT1) genes alter risk, clinicopathological aspects and survival of cutaneous melanoma (CM). Genotyping was performed in 229 CM patients and 258 controls. Individuals with XPD 312Asp/Asn or Asn/Asn plus GSTT1 null genotype were under 2. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/exd.13914DOI Listing
March 2019
1 Read

How hormones may modulate human skin pigmentation in melasma: an in vitro perspective.

Authors:
Muriel Cario

Exp Dermatol 2019 Mar 18. Epub 2019 Mar 18.

Univ. Bordeaux, Inserm, BMGIC, UMR1035, 33 076, Bordeaux, France.

Melasma is a common acquired hyperpigmentary disorder occurring primarily in photo-exposed areas and mainly affecting women of childbearing age. To decipher the role of sex hormones in melasma, this viewpoint reviews the effects of sex hormones on cutaneous cells cultured in monolayers, in coculture, in 3D models and explants in the presence or absence of UV. The data show that sex steroid hormones, especially estrogen, can modulate in vitro pigmentation by stimulating melanocytes and keratinocyte pro-pigmentary factors, but not via fibroblast or mast cell activation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/exd.13915DOI Listing
March 2019
1 Read

Clinical Snippets.

Authors:

Exp Dermatol 2019 Mar;28(3)

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/exd.13906DOI Listing

Osthole attenuates mouse atopic dermatitis by inhibiting thymic stromal lymphopoietin production from keratinocytes.

Exp Dermatol 2019 Mar 2. Epub 2019 Mar 2.

Quanzhou Medical College People's Hospital Affiliated, N0 95 Fengze Street, Fengze District, Quanzhou, 362000, Fujian, China.

Atopic dermatitis is one of the most common skin diseases. Dysregulation of immune system and chronic inflammation were believed to be associated with atopic dermatitis. Osthole was reported to play important roles in anti-tumor and anti-inflammation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/exd.13910DOI Listing
March 2019
2 Reads

Understanding the immune landscape in atopic dermatitis: The era of biologics and emerging therapeutic approaches.

Exp Dermatol 2019 Mar 2. Epub 2019 Mar 2.

Icahn School of Medicine at Mount Sinai, New York City, New York.

Atopic dermatitis (AD) is a chronic, systemic, inflammatory disease that affects the skin and is characterized by persistent itch and marked redness. AD is associated with an increased risk of skin infections and a reduced quality of life. Most AD treatment options to date were not designed to selectively target disease-causing pathways that have been established for this indication. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/exd.13911DOI Listing
March 2019
5 Reads

Baicalein inhibits matrix metalloproteinase 1 expression via activation of TRPV1-Ca-ERK pathway in ultraviolet B-irradiated human dermal fibroblasts.

Exp Dermatol 2019 Mar 2. Epub 2019 Mar 2.

Department of Biochemistry, National Defense Medical Center, Taipei, Taiwan, Republic of China.

Increased matrix metalloproteinase 1 (MMP-1) expression is a feature of photo-aged skin. We investigated the effects of baicalein and sulphoraphane on ultraviolet B (UVB) irradiation-induced MMP-1 expression and apoptosis using human dermal fibroblasts. UVB irradiation not only increased MMP-1 expression, but also caused apoptosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/exd.13912DOI Listing
March 2019
2 Reads

Differential expression of inflammatory cytokines and chemokines in lipopolysaccharide-stimulated melanocytes from lightly and darkly pigmented skin.

Exp Dermatol 2019 Feb 23. Epub 2019 Feb 23.

Department of Instrumental Analysis, School of Pharmacy with the Division of Laboratory Medicine, Medical University of Silesia in Katowice, Sosnowiec, Poland.

Increasing evidence suggests that human epidermal melanocytes play an important role in the skin immune system; however, a role of their pigmentation in immune and inflammatory responses is poorly examined. In the study, the expression of Toll-like receptor 4 (TLR4) and inflammatory cytokines and chemokines by cultured normal melanocytes derived from lightly and darkly pigmented skin was investigated after cell stimulation with lipopolysaccharide (LPS). The basal TLR4 mRNA level in heavily pigmented cells was higher as compared to their lightly pigmented counterparts. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/exd.13908DOI Listing
February 2019
2 Reads

The complex role of mast cells in fungal infections.

Exp Dermatol 2019 Feb 23. Epub 2019 Feb 23.

Department of Dermatology and Allergy, Charité - Universitätsmedizin Berlin, Berlin, Germany.

In addition to their critical role in allergic disorders, mast cells (MCs) are well recognized for their protective effector functions during bacteria and parasite infections. This review describes recent advancements of our understanding of the complex role of MCs in fungal infections. Specifically, we outline key features of the contribution of MCs to infections with six fungal pathogens, namely Sporothrix, Paracoccidioides, Aspergillus, Malassezia, Candida and Dermatophytes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/exd.13907DOI Listing
February 2019

A multiscale hybrid mathematical model of epidermal-dermal interactions during skin wound healing.

Exp Dermatol 2019 Feb 23. Epub 2019 Feb 23.

NSF-Simons Center for Multiscale Cell Fate Research, University of California, Irvine, Irvine, CA, 92697, USA.

Following injury, skin activates a complex wound healing program. While cellular and signaling mechanisms of wound repair have been extensively studied, the principles of epidermal-dermal interactions and their effects on wound healing outcomes are only partially understood. To gain new insight into the effects of epidermal-dermal interactions, we developed a multiscale, hybrid mathematical model of skin wound healing. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/exd.13909DOI Listing
February 2019

Naringenin as an opener of mitochondrial potassium channels in dermal fibroblasts.

Exp Dermatol 2019 Feb 18. Epub 2019 Feb 18.

Department of Biophysics, Warsaw, University of Life Sciences - SGGW, Warsaw, Poland.

Flavonoids belong to a large group of polyphenolic compounds that are widely present in plants. Certain flavonoids, including naringenin, have cytoprotective properties. Although the antioxidant effect has long been thought to be a crucial factor accounting for the cellular effects of flavonoids, mitochondrial channels have emerged recently as targets for cytoprotective strategies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/exd.13903DOI Listing
February 2019
3 Reads

Imaging of pH and pO gives insight in molecular processes of irradiated cells.

Exp Dermatol 2019 Feb 18. Epub 2019 Feb 18.

Department of Otorhinolaryngology, Ludwig-Maximilians-University Munich, Munich, Germany.

One of the major challenges in radiation therapy is the interference with tissue repair processes due to hypoxic characteristics and pH dysregulation. In this study, we present dual imaging of pH and oxygenation in vitro based on luminescent biocompatible sensor foils that allow studying the effects of irradiation on different cell types in culture. Different sensitivities of fibroblast and oral squamous carcinoma cells were observed by complementing oxygen and pH differences with proliferation assays. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/exd.13905DOI Listing
February 2019
2 Reads

Do human dermal adipocytes switch from lipogenesis in anagen to lipophagy and lipolysis during catagen in the human hair cycle?

Exp Dermatol 2019 Feb 18. Epub 2019 Feb 18.

Centre for Dermatology Research, The University of Manchester, Manchester, UK.

In murine skin, dermal white adipose tissue (DWAT) undergoes fluctuations in size across the hair cycle, whereas changes in size, function and metabolism of dermal adipocytes (DAs) during the human scalp hair cycle remain unexplored. Transmission electron microscopy results suggest that during anagen-catagen transition, human DAs co-opt the autophagy machinery to undergo lipophagy within their lipid droplets. Whole-mount staining of hair follicles (HFs) and surrounding DWAT for the autophagy marker LC3B confirms the increased presence of LC3B+ lipid droplets adjacent to catagen HFs; moreover, DWAT around catagen HFs engages in greater glycerol release compared to DWAT surrounding anagen HFs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/exd.13904DOI Listing
February 2019
1 Read

Topical kinase inhibitors induce regression of cutaneous squamous cell carcinoma.

Exp Dermatol 2019 Feb 14. Epub 2019 Feb 14.

Department of Dermatology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.

Actinic keratoses (AKs) and squamous cell carcinoma in situ (SCCIS) are precursor lesions for cutaneous squamous cell carcinoma (cSCC), the second most common form of cancer. Current topical therapies for AKs and SCCIS promote skin inflammation to eradicate lesions and do not directly target the biological mechanisms driving growth. We hypothesized that topical small molecule inhibitors targeting kinases promoting keratinocyte growth in AKs and SCCIS could induce regression of these lesions with less inflammation. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/exd.13902
Publisher Site
http://dx.doi.org/10.1111/exd.13902DOI Listing
February 2019
4 Reads

Dissection of Merkel cell formation in hairy and glabrous skin reveals a common requirement for FGFR2-mediated signalling.

Exp Dermatol 2019 Feb 13. Epub 2019 Feb 13.

Department of Cell, Developmental, and Regenerative Biology, Black Family Stem Cell Institute, The Tisch Cancer Institute, New York City, New York.

Merkel cells are mechanosensory cells involved in tactile discrimination. Merkel cells have been primarily studied in the murine back skin, where they are found in specialized structures called touch domes located around primary hair follicles. Yet, little is known about the morphogenesis of Merkel cells in areas of the skin devoid of hair, such as the glabrous paw skin. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/exd.13901DOI Listing
February 2019

A potential contribution of decreased galectin-7 expression in stratified epithelia to the development of cutaneous and esophageal manifestations in systemic sclerosis.

Exp Dermatol 2019 Feb 9. Epub 2019 Feb 9.

Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, 113-8655, Japan.

Backgrounds: Stratified epithelia have caught much attention as potential contributors to the development of dermal and esophageal fibrosis in systemic sclerosis (SSc). Galectin-7 is a marker of all types of stratified epithelia, which is involved in the maintenance of epidermal homeostasis. So far, the role of galectin-7 has not been studied in SSc. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/exd.13900DOI Listing
February 2019
4 Reads

Comparative regenerative biology of spiny (Acomys cahirinus) and laboratory (Mus musculus) mouse skin.

Exp Dermatol 2019 Feb 8. Epub 2019 Feb 8.

Department of Pathology, School of Medicine, University of Southern California, Los Angles, California, USA.

Wound-induced hair follicle neogenesis (WIHN) has been demonstrated in laboratory mice (Mus musculus) after large (>1.5 x 1.5 cm ) full-thickness wounds. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/exd.13899DOI Listing
February 2019
3.762 Impact Factor

Wanted, dead and alive; why a multidisciplinary approach is needed to unlock hair treatment potential.

Exp Dermatol 2019 Feb 1. Epub 2019 Feb 1.

Skin Research Institute Singapore, Singapore.

Human recorded history is littered with attempts to improve the perceived appearance of scalp hair. Throughout history treatments have included both biological and chemical interventions. Hair "quality" or "perceived appearance" is regulated by multiple biological intervention opportunities: adding more hairs by flipping follicles from Telogen to Anagen, or delaying Anagen follicles transiting into Catagen; altering hair "apparent amount" by modulating shaft diameter or shape; or, in principle, altering shaft physical properties changing its synthesis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/exd.13898DOI Listing
February 2019
2 Reads

IL-17A/F in Leishmania major-resistant C57BL/6 mice.

Exp Dermatol 2019 Mar;28(3):321-323

Department of Dermatology, University Hospital of the Johannes Gutenberg-University Mainz, Mainz, Germany.

Proinflammatory IL-17 plays an important role in various diseases and defence against extracellular microorganisms. Healing of leishmaniasis is promoted by Th1/Tc1 cells, whereas Th2/Treg are associated with worsened disease outcome. In addition, high expression of IL-17A in Leishmania-susceptible BALB/c and artificial overexpression of IL-17A in T cells in resistant C57BL/6 mice worsened disease outcome. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/exd.13896DOI Listing
March 2019
1 Read

Skin equivalent assay: An optimized method for testing for hair growth reconstitution capacity of epidermal and dermal cells.

Exp Dermatol 2019 Jan 31. Epub 2019 Jan 31.

Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea.

Hair follicle reconstitution requires highly organized epithelial-mesenchymal interactions. Skin equivalents containing the epidermal and dermal cells with hair reconstitution capacity can reproduce these processes, but have not been established. This study was conducted to develop a hair follicle-producing three-dimensional (3D) skin equivalent assay using neonate mouse epidermal and dermal cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/exd.13897DOI Listing
January 2019
10 Reads