1,414,678 results match your criteria Experimental Cell Research [Journal]
Eur J Phys Rehabil Med 2018 Dec 14. Epub 2018 Dec 14.
School of Psychology, Faculty of Health Sciences, Australian Catholic University, Melbourne, Australia.
Background: Executive dysfunctioning after pediatric traumatic brain injury (TBI) has been linked to poor outcomes in school performance, social functioning and employment. The credibility of training-induced cognitive enhancement in TBI is threatened by its limited proof of benefit in executive skills of daily living.
Aim: Our primary aim was to investigate if cognitive intervention for improving impairments in executive functions in the chronic stage of traumatic brain injury is effective during adolescence. Read More
Methods Mol Biol 2019 ;1894:281-299
Pharmaceutical Sciences Department, University of Kentucky Academic Medical Center, Lexington, KY, USA.
The role and functional anatomy of the blood-brain barrier (BBB) is summarized to enable the investigator to appropriately address evaluation of nanomaterial interaction with, and distribution across, it into brain tissue (parenchyma). Transport mechanisms across the BBB are presented, in relation to nanomaterial physicochemical properties. Measures and test substances to assess BBB integrity/disruption/permeation are introduced, along with how they are used to interpret the results obtained with the presented methods. Read More
Methods Mol Biol 2019 ;1903:291-316
Department of Systems and Computer Engineering, Carleton University, Ottawa, ON, Canada.
Using existing drugs for diseases which are not developed for their treating (drug repositioning) provides a new approach to developing drugs at a lower cost, faster, and more secured. We proposed a method for drug repositioning which can predict simple and complex relationships between drugs, drug targets, and diseases. Since biological networks typically present a suitable model for relationships between different biological concepts, our primary approach is to analyze graphs and complex networks in the study of drugs and their therapeutic effects. Read More
Methods Mol Biol 2019 ;1903:239-254
Division of Software and Information Systems, School of Computer Science and Engineering, Nanyang Technological University, Singapore, Singapore.
Therapeutic effects of drugs are mediated via interactions between them and their intended targets. As such, prediction of drug-target interactions is of great importance. Drug-target interaction prediction is especially relevant in the case of drug repositioning where attempts are made to repurpose old drugs for new indications. Read More
Methods Mol Biol 2019 ;1903:97-113
Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy.
The wealth of knowledge and omic data available in drug research allowed the rising of several computational methods in drug discovery field yielding a novel and exciting application called drug repositioning. Several computational methods try to make a high-level integration of all the knowledge in order to discover unknown mechanisms. In this chapter we present an in-depth review of data resources and computational models for drug repositioning. Read More
Curr Top Behav Neurosci 2018 Dec 15. Epub 2018 Dec 15.
Sociograph Marketing Science Consulting, Valladolid, Spain.
Testing cognitive hypotheses in extinct species can be challenging, but it can be done through the integration of independent sources of information (e.g., anatomy, archaeology, neurobiology, psychology), and validated with quantitative and experimental approaches. Read More
Ambio 2018 Dec 13. Epub 2018 Dec 13.
Department of Integrative Biology, College of Biological Science, University of Guelph, Guelph, ON, N1G 2W1, Canada.
The chemical composition of non-lead, non-toxic, gunshot used for hunting waterfowl is regulated only in Canada and the USA. No nation regulates the composition of non-lead fishing weights, rifle bullets, and gunshot used for upland game hunting. Compositional criteria for these non-lead products are proposed here, based on established experimental toxicity protocols. Read More
Methods Mol Biol 2019 ;1883:385-422
Institute of Computational Biology, Helmholtz Zentrum München, Neuherberg, Germany.
Ordinary differential equation models have become a standard tool for the mechanistic description of biochemical processes. If parameters are inferred from experimental data, such mechanistic models can provide accurate predictions about the behavior of latent variables or the process under new experimental conditions. Complementarily, inference of model structure can be used to identify the most plausible model structure from a set of candidates, and, thus, gain novel biological insight. Read More
Methods Mol Biol 2019 ;1883:303-321
Division of Genetics and Genomics, The Roslin Institute, University of Edinburgh, Midlothian, Scotland, UK.
Module network inference is a statistical method to reconstruct gene regulatory networks, which uses probabilistic graphical models to learn modules of coregulated genes and their upstream regulatory programs from genome-wide gene expression and other omics data. Here, we review the basic theory of module network inference, present protocols for common gene regulatory network reconstruction scenarios based on the Lemon-Tree software, and show, using human gene expression data, how the software can also be applied to learn differential module networks across multiple experimental conditions. Read More
Methods Mol Biol 2019 ;1883:235-249
Data Mining and Modelling for Biomedicine, VIB Center for Inflammation Research, Ghent, Belgium.
Recent technological breakthroughs in single-cell RNA sequencing are revolutionizing modern experimental design in biology. The increasing size of the single-cell expression data from which networks can be inferred allows identifying more complex, non-linear dependencies between genes. Moreover, the inter-cellular variability that is observed in single-cell expression data can be used to infer not only one global network representing all the cells, but also numerous regulatory networks that are more specific to certain conditions. Read More
Diabetes Ther 2018 Dec 13. Epub 2018 Dec 13.
Clinical and Experimental Endocrinology, University Hospital Leuven, Catholic University of Leuven, Leuven, Belgium.
Introduction: The aim of this study was to investigate the association between baseline characteristics [HbA1c and body mass index (BMI)] and the effect of mealtime fast-acting insulin aspart (faster aspart) relative to insulin aspart (IAsp) or basal-only insulin therapy on several efficacy and safety outcomes in people with diabetes.
Methods: Post hoc analysis of three randomised phase 3a trials in people with type 1 diabetes (T1D; onset 1) and type 2 diabetes (T2D; onset 2 and 3). Participants (N = 1686) were stratified according to baseline BMI (< 25 kg/m, 25-< 30 kg/m, ≥ 30 kg/m) or HbA1c (≤ 58 mmol/mol, > 58-< 64 mmol/mol, ≥ 64 mmol/mol; ≤ 7. Read More
J Clin Immunol 2018 Dec 13. Epub 2018 Dec 13.
Paediatric Immunology Unit, Department of Paediatric Pulmonology, Allergology and Neonatology, Hanover Medical School, Carl-Neuberg Str. 1, 30625, Hannover, Germany.
Studies of chest computed tomography (CT) in patients with primary antibody deficiency syndromes (ADS) suggest a broad range of bronchial pathology. However, there are as yet no multicentre studies to assess the variety of bronchial pathology in this patient group. One of the underlying reasons is the lack of a consensus methodology, a prerequisite to jointly document chest CT findings. Read More
Wien Med Wochenschr 2018 Dec 13. Epub 2018 Dec 13.
Department of Plastic and Reconstructive Surgery, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria.
Artificial and non-artificial nerve grafts are the gold standard in peripheral nerve reconstruction in cases with extensive loss of nerve tissue, particularly where a direct end-to-end suture or an autologous nerve graft is inauspicious. Different materials are marketed and approved by the US Food and Drug Administration (FDA) for peripheral nerve graft reconstruction. The most frequently used materials are collagen and poly(DL-lactide-ε-caprolactone). Read More
Environ Sci Pollut Res Int 2018 Dec 13. Epub 2018 Dec 13.
Department of Chemical & Materials Engineering, University of Auckland, 2-6 Park Avenue - Bldg 529, Grafton, Auckland, 1023, New Zealand.
Struvite precipitation has drawn much attention in the last decade as a green chemical process for phosphorus removal and recovery. Product purity affects the usefulness, and thus price, of the product when recovered struvite is sold as fertilizer. However, there is currently little research on struvite quality, as well as on models for accurately predicting. Read More
Environ Sci Pollut Res Int 2018 Dec 13. Epub 2018 Dec 13.
Department of Veterinary Biomedical Sciences, PMAS Arid Agriculture University, Rawalpindi, PK-46300, Pakistan.
Cadmium and mercury are among the most toxic and dangerous environmental pollutants that may cause fatal implications. Vitamin C is an important chain-breaking antioxidant and enzyme co-factor against heavy metals. The objective of the present study was to evaluate the toxicological effects of cadmium chloride, mercuric chloride, and their co-administration on biochemical parameters of blood serum and metal bioaccumulation in kidneys and also to elucidate the protective effect of vitamin C in rabbits against these metals. Read More
Environ Sci Pollut Res Int 2018 Dec 13. Epub 2018 Dec 13.
Graduate Program in Environment and Regional Development, University of Western São Paulo - UNOESTE, Presidente Prudente, SP, 19067-175, Brazil.
Contamination caused by leakage at gas stations leads to possible exposure of the general population when in contact with contaminated water and soil. The present study aimed to evaluate the reproductive effects of exposure of adult male rats to gasohol and evaluate the performance of machine learning (ML) algorithms for pattern recognition and classification of the exposure groups. Rats were orally exposed to 0 (control), 16 (EA), 160 (EB), or 800 mg kg bw day of gasohol (EC), for 30 consecutive days. Read More
Environ Sci Pollut Res Int 2018 Dec 13. Epub 2018 Dec 13.
Department of Civil and Environment Engineering, The Hong Kong Polytechnic University, Hong Kong, People's Republic of China.
Graphene has been considered an ideal absorbent and excellent carrier for nanoparticles. Reduced graphite oxide (rGO)-supported nanoscale zero-valent iron (nZVI@rGO) is an effective material for removing nitrate from water. nZVI@rGO nanocomposites were prepared by a liquid-phase reduction method and then applied for nitrate-nitrogen (NO-N) removal in aqueous solution under anaerobic conditions. Read More
J Abnorm Child Psychol 2018 Dec 13. Epub 2018 Dec 13.
Department of Pediatrics, Center for Advancement of Youth, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, 39216, USA.
Inhibition is a key neurocognitive domain in ADHD that is commonly assessed with the stop-signal task. The stop-signal involves both "go" and "stop" trials; previous research indicates that response times are reliably slower to "go" trials during tasks with vs. without intermittent "stop" trials. Read More
J Nucl Cardiol 2018 Dec 13. Epub 2018 Dec 13.
Nuclear Medicine Unit, Department of Experimental and Clinical Biomedical Sciences, University of Florence, Largo Brambilla 3, 50134, Florence, Italy.
J Med Syst 2018 Dec 13;43(1):18. Epub 2018 Dec 13.
Department of electronic information, Sichuan University, Chengdu, China.
We propose an improved model based on LVW embedded model feature extractor and ensemble learning for improving prediction accuracy of hemodialysis timing in this paper. Due to this drawback caused by feature extraction models, we adopt an enhanced LVW embedded model to search the feature subset by stochastic strategy, which can find the best feature combination that are most beneficial to learner performance. In the model application, we present an improved integrated learners for model fusion to reduce errors caused by overfitting problem of the single classifier. Read More
Sports Med Open 2018 Dec 13;4(1):55. Epub 2018 Dec 13.
Åstrand Laboratory of Work Physiology, The Swedish School of Sport and Health Sciences, Stockholm, Sweden.
Background: Strength and power development are abilities important for athletic performance in many sports. Generally, resistance training based on gravity is used to improve these qualities. Flywheel training instead utilizes kinetic energy transferred to a flywheel. Read More
Diabetologia 2018 Dec 14. Epub 2018 Dec 14.
Institute of Cellular Medicine, Faculty of Clinical Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.
Diabetologia 2018 Dec 14. Epub 2018 Dec 14.
Department of Medicine, Division of Diabetes, Endocrinology, and Metabolism, 7465 Medical Research Bldg IV, Vanderbilt University Medical Center, 2215 Garland Avenue, Nashville, TN, 37232-0475, USA.
Over the last two decades, improved access to human islets and the development of human islet distribution networks have enabled the use of millions of human islets in hundreds of scientific research projects, leading to a dramatic increase in our understanding of human islet biology. Here we discuss recent scientific advances as well as methodological and experimental challenges that impact human islet quality, experimental outcomes and the reporting of human islets used in scientific publications. In a survey of over 200 scientific publications with human islet experimentation, we found that the reporting of critical information was quite variable, sometimes obscure, and often failed to adequately outline the experiments and results using human islets. Read More
Eur J Nucl Med Mol Imaging 2018 Dec 13. Epub 2018 Dec 13.
Oncology Division, Rambam Health Care Campus, 8 Ha'Aliya Hashniya, and Technion - Israel Institute of Technology, 1 Efron Street, Haifa, Israel.
Purpose: Concomitant treatment with radium-223 and paclitaxel is a potential option for cancer patients with bone metastases; however, myelosuppression risk during coadministration is unknown. This phase Ib study in cancer patients with bone metastases evaluated the safety of radium-223 and paclitaxel.
Methods: Eligible patients had solid tumor malignancies with ≥2 bone metastases and were candidates for paclitaxel. Read More
Analyst 2018 Dec 14. Epub 2018 Dec 14.
Centro de Investigación Príncipe Felipe, Valencia, Spain.
Gold nanoparticles have high potential in the biomedical area, especially in disease diagnosis and treatment. The application of these nanoparticles requires the presence of stabilizers to avoid their agglomeration. Nowadays, there is a lack of reliable methods for characterising the effect of stabilised nanoparticles on biological systems. Read More
Phys Chem Chem Phys 2018 Dec 14. Epub 2018 Dec 14.
Institute of Physics, Faculty of Physics, Astronomy and Informatics, Nicolaus Copernicus University in Toruń, Grudziądzka 5, 87-100 Toruń, Poland.
Understanding the binding mechanism in neptunyl clusters formed due to cation-cation interactions is of crucial importance in nuclear waste reprocessing and related areas of research. Since experimental manipulations with such species are often rather limited, we have to rely on quantum-chemical predictions of their electronic structures and spectroscopic parameters. In this work, we present a state-of-the-art quantum chemical study of the T-shaped and diamond-shaped neptunyl(v) and neptunyl(vi) dimers. Read More
Phys Chem Chem Phys 2018 Dec 14. Epub 2018 Dec 14.
Department of Chemistry, University College London, 20 Gordon Street, London WC1H 0AJ, UK. and Cardiff University, School of Chemistry, Main Building, Park Place, Cardiff, CF1D 3AT, UK.
The magnetic structure of the actinide dioxides (AnO2) remains a field of intense research. A low-temperature experimental investigation of the magnetic ground-state is complicated by thermal energy released from the radioactive decay of the actinide nuclei. To establish the magnetic ground-state, we have employed high-accuracy computational methods to systematically probe different magnetic structures. Read More
Dalton Trans 2018 Dec 14. Epub 2018 Dec 14.
National Nuclear Laboratory, Central Laboratory, Sellafield, Cumbria CA20 1PG, UK.
Simple hydroxamic acids such as acteohydroxamic acid (AHA) have been identified as suitable reagents for the control of Pu and Np in advanced separation processes for nuclear fuel reprocessing such as the Advanced PUREX or UREX based recycle processes, due to their ability to strip the tetravalent form of Pu and Np from tri-butyl phosphate into nitric acid. However, both free and metal bound hydroxamates are known to undergo acid catalysed hydrolysis at low pH, the kinetics of which must be characterised before implementation of PUREX/UREX based reprocessing flowsheets. In support of this implementation, a comprehensive thermodynamic and kinetic model that describes both the complex speciation and hydrolysis of AHA in the presence of Np(iv) has been developed. Read More
Acad Pathol 2018 Jan-Dec;5:2374289518816502. Epub 2018 Dec 4.
Department of Pathology and Laboratory Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, USA.
Acute kidney injury, especially early-stage disease, is a common hospital comorbidity requiring timely recognition and treatment. We investigated the effect of daily laboratory alerting of patients at risk for acute kidney injury as measured by documented diagnoses. A quasi-experimental study was conducted at 8 New York hospitals between January 1, 2014, and June 30, 2017. Read More
Smart Health (Amst) 2018 Dec 7;9-10:88-100. Epub 2018 Jul 7.
Erik Jonsson School of Engineering and Computer Science, The University of Texas at Dallas, United States.
We develop a pipeline to mine complex drug interactions by combining different similarities and interaction types (molecular, structural, phenotypic, genomic etc). Our goal is to learn an optimal kernel from these heterogeneous similarities in a supervised manner. We formulate an extensible framework that can easily integrate new interaction types into a rich model. Read More
Data Brief 2018 Dec 27;21:2447-2463. Epub 2018 Oct 27.
Institute for Mineralogy, University of Münster, Corrensstrasse 24, 48149 Münster, Germany.
This article provides new data on mineral/melt partitioning in systems relevant to the evolution of chondrites, Calcium Aluminum-Rich Inclusions (CAI) in chondrites and related meteorites. The data set includes experimentally determined mineral/melt partition coefficients between hibonite (CaAlO), melilite (Ca(Al,Mg)SiO), spinel (MgAlO) and silicate melts for a wide range of trace elements: Sc, Ti, V, Cr, Co, Ni, Cu, Zn, Ga, Ge, Rb, Sr, Y, Zr, Nb, Rh, Cs, Ba, La, Ce, r, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb, Lu, Hf, Ta, W, Pb, Th and U. The experiments were performed at high temperatures (1350 °C < < 1550 °C) and ambient pressure. Read More
Data Brief 2018 Dec 23;21:2430-2434. Epub 2018 Nov 23.
Immanuel Kant Baltic Federal University, A. Nevskogo St. 14, 236016 Kaliningrad, Russia.
This data article contains Raman experimental data, obtained with Horiba Jobin-Yvon LabRam HR800 spectrometer (Japan), which can be used for rapid identification of () bacteria (Beijing clade) . Data present analyzed Raman spectra of bacterial cells with various drug resistances obtained from pulmonary and extra pulmonary samples. Data can provide information about characteristic maxima of different structures in biological cell. Read More
Data Brief 2018 Dec 26;21:2398-2404. Epub 2018 Nov 26.
Newborn Screening, Biochemistry and Pharmacology Laboratory, Pediatric Neurology Unit and Laboratories, Meyer Children׳s University Hospital, Florence, Italy.
This article provides supplementary data for the paper "LC-MS/MS method for simultaneous quantification of heparan sulfate and dermatan sulfate in urine by butanolysis derivatization" (Forni et al., 2018). Several parameters were tested to optimize sample preparation by butanolysis in order to carry out simultaneous quantifications of HS and DS by tandem mass spectrometry. Read More
Front Mol Biosci 2018 28;5:104. Epub 2018 Nov 28.
Department of Experimental Medicine, University of Perugia, Perugia, Italy.
The rise in the frequency of nosocomial infections is becoming a major problem for public health, in particular in immunocompromised patients. is an opportunistic fungus normally present in the environment directly responsible for lethal invasive infections. Recent results suggest that the metabolic pathways related to amino acid metabolism can regulate the fungus-host interaction and that an important role is played by enzymes involved in the catabolism of L-tryptophan. Read More
Front Oncol 2018 28;8:561. Epub 2018 Nov 28.
Department of Gastroenterology, University Hospital of North Norway, Tromsø, Norway.
The development of colorectal cancer (CRC) is not only determined by transformed cells , but also by factors existing in their immune microenvironment. Accumulating scientific evidence has revealed that interleukin (IL)-33, an IL-1 family member, plays an essential role in the regulation of immune response and is relevant in CRC pathogenesis. Data from both human and experimental studies demonstrated that IL-33 inhibits host anti-tumor immunity, remodels tumor stroma and enhances angiogenesis, thereby promoting the development of CRC. Read More
Curr Hepatol Rep 2018 18;17(3):200-208. Epub 2018 Jun 18.
1Division of Gastroenterology, Azienda Ospedaliero-Universitaria di Modena and University of Modena and Reggio Emilia, Modena, Italy.
Purpose Of Review: To revise experimental and clinical data supporting a less traditional role of anticoagulation for treating portal hypertension in patients with cirrhosis.
Recent Findings: Portal hypertension is the main driver of complications such as ascites, variceal hemorrhage, and hepatic encephalopathy, with inflammation as a key component. The traditional view of cirrhosis as a pro-hemorrhagic condition has recently changed, prothrombotic complications being recognized as frequently as the hemorrhagic ones. Read More
Oncoimmunology 2019 2;8(1):e1523097. Epub 2018 Nov 2.
Department of Radiation Oncology, University Hospital, Munich, Germany.
The major goal of radiotherapy is the induction of tumor cell death. Additionally, radiotherapy can function as cancer vaccination by exposing tumor antigens and providing adjuvants for anti-tumor immune priming. In this regard, the mode of tumor cell death and the repertoire of released damage-associated molecular patterns (DAMPs) are crucial. Read More
J Clin Imaging Sci 2018 15;8:52. Epub 2018 Nov 15.
Department of Biotechnological and Applied Clinical Science, University of L'aquila, L'aquila, Italy.
Purpose: The aim of this study was to compare image quality and mean radiation dose between two groups of patients undergoing coronary computed tomography angiography (CCTA) using a 640-slice CT scanner with two protocols with different noise level thresholds expressed as standard deviation (SD).
Materials And Methods: Two-hundred and sixty-eight patients underwent a CCTA with 640 slice CT scanner. In the experimental group (135 patients), an SD 51 protocol was employed; in the control group (133 patients), an SD 33 protocol was used. Read More
Mol Clin Oncol 2018 Dec 1;9(6):689-696. Epub 2018 Oct 1.
Department of Medical Oncology, Santa Maria della Misericordia Hospital, AOU di Perugia, I-06129 Perugia, Italy.
The aim of the present study was to assess the expression of select DNA repair and synthesis genes in non-small-cell lung cancer (NSCLC) according to mutation status. ERCC1, TS, RRM1, and BRCA1 mRNA expression levels were assessed from either primary or metastatic tumor specimens of patients diagnosed with epidermal growth factor receptor () wild-type (WT) advanced NSCLC. Total RNA was isolated from paraffin-embedded tumor specimens using the RNeasy FFPE kit and automatically purified using a QiaCube instrument. Read More
J Glob Health 2019 Jun;9(1):010501
Clinton Health Access Initiative, New Delhi, India.
Background: The Clinton Health Access Initiative implemented a program from 2012-2016 to increase use of oral rehydration salts (ORS) and zinc to treat diarrhea in children under five in three states in India: Gujarat, Madhya Pradesh, and Uttar Pradesh. The program interventions included detailing and development of a rural supply chain to reach private rural health care providers, training of Accredited Social Health Activists (ASHAs), technical support to the state governments, and a mass media campaign targeted at caregivers. In Gujarat and Uttar Pradesh, some of the program activities, such as detailing and ASHA trainings, were targeted to high-burden focal districts, thus providing an opportunity to study their effect compared to statewide activities that covered all districts, such as the mass media campaign. Read More
Dement Neuropsychol 2018 Oct-Dec;12(4):337-352
PhD, Center for Alzheimer's disease and Related Disorders, Institute of Psychiatry, Universidade Federal do Rio de Janeiro, RJ, Brazil.
Metamemory is the awareness of one's own knowledge and control of memory, and refers to the online ability to gather information about the current state of the memory system.
Objective: Metamemory is one's own knowledge and control of memory. A systematic review was performed to identify the types of tasks used for evaluating metamemory monitoring, the stimuli used in these tasks, their limitations and the outcomes in people with Alzheimer's disease (PwAD). Read More
Oncotarget 2018 Nov 16;9(90):36238-36249. Epub 2018 Nov 16.
Université Côte d'Azur, CHU Nice, FHU OncoAge, Laboratory of Clinical and Experimental Pathology, Pasteur Hospital, Nice, France.
The mutation status of the and genes in tumor tissue is used to select patients with metastatic melanoma for targeted therapy. Cell-free circulating DNA (cfDNA) represents an accessible, non-invasive surrogate sample that could provide a snapshot of the and genotype in these patients. We investigated the feasibility of the Idylla™ assay for detection of and mutations in cfDNA of 19 patients with metastatic melanoma at baseline and during the course of treatment. Read More
Oncotarget 2018 Nov 16;9(90):36220-36237. Epub 2018 Nov 16.
Department of Internal Medicine I, University of Bonn, Bonn, Germany.
Background And Aims: Angiogenesis is critically involved in the development of liver fibrosis, portal hypertension (PHT) and hepatocellular carcinoma (HCC). Regorafenib is a novel second-line therapy for HCC, but might also be beneficial in fibrosis and PHT even in absence of HCC. This study investigated the effects of regorafenib in experimental models without HCC. Read More
Oncol Lett 2018 Dec 27;16(6):7152-7157. Epub 2018 Sep 27.
Department of Oncology, The First Affiliated Hospital of Hunan Normal University (People's Hospital of Hunan Province), Changsha, Hunan 410005, P.R. China.
Expression, clinical significance and molecular mechanism of miR-204 in human retinoblastoma (RB) and para-carcinoma tissues were investigated. A total of 110 cases of RB tissues preserved after ophthalmectomy in the First Affiliated Hospital of Hunan Normal University (People's Hospital of Hunan Province) from April 2013 to June 2017 were collected along with 100 cases of para-carcinoma normal tissues. The expression of miR-204 in RB tissues was detected via reverse transcription-quantitative polymerase chain reaction (RT-qPCR), and its associations with clinicopathological features were analyzed. Read More
Oncol Lett 2018 Dec 9;16(6):7091-7096. Epub 2018 Oct 9.
Department of Molecular Biotechnology and Health Sciences, Center for Experimental Research and Medical Studies, University of Torino, I-10126 Torino, Italy.
Recent studies reported the expression of anaplastic lymphoma kinase (ALK) in malignant melanomas. The aim of this study was to investigate whether ALK expression is associated with specific clinical and molecular characteristics of melanoma metastases, and to evaluate its correlation with survival outcomes. Seventy-one patients with metastatic melanoma were investigated. Read More
Oncol Lett 2018 Dec 25;16(6):6988-6997. Epub 2018 Sep 25.
Worldwide Medical Center, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China.
Acute megakaryocytic leukemia (AMKL) is a rare subtype of acute myeloid leukemia (AML), which is challenging to diagnose due to frequent myelofibrosis (MF) and a low percentage of blast cells. In the present study, clinical characteristics and experimental observations in 9 adult patients diagnosed with AMKL, who were recruited by the Sino-U.S. Read More
Exp Ther Med 2018 Dec 19;16(6):4493-4498. Epub 2018 Sep 19.
Department of Neurology, Binzhou City Center Hospital, Binzhou, Shandong 251700, P.R. China.
Effects of gastrodin on 5-HT and neurotrophic factor in the treatment of patients with post-stroke depression (PSD) were investigated. A total of 78 PSD patients were selected in Binzhou City Center Hospital from September 2013 to December 2016. Patients were randomly divided into the control group and experimental group, 39 patients in each group. Read More
Exp Ther Med 2018 Dec 27;16(6):4401-4406. Epub 2018 Sep 27.
Department of Neurology, The Second People's Hospital of Liaocheng, Liaocheng, Shandong 252601, P.R. China.
The aim of the study was to investigate and discuss the activation of astrocytes and the expression of inflammatory cytokines in rats with experimental autoimmune encephalomyelitis (EAE). Twenty Wistar rats were randomly divided into the normal control (n=10) and EAE group (n=10). The rats in the EAE group were injected intraperitoneally with myelin oligodendrocyte glycoprotein 35-55 emulsion, and those in the control group were injected with the equivalent volume of normal saline. Read More
Front Immunol 2018 28;9:2801. Epub 2018 Nov 28.
Institute for Translational Medicine, Medical College of Qingdao University, Qingdao, China.
Non-coding RNAs (ncRNAs) are functional RNA molecules that are transcribed from DNA but not translated into proteins. ncRNAs function as key regulators of gene expression and chromatin modification. Recently, the functional role of ncRNAs in teleost fish has been extensively studied. Read More
Front Neurol 2018 28;9:1027. Epub 2018 Nov 28.
Molecular Genetics Laboratory UILDM, Santa Lucia Foundation, Rome, Italy.
Facioscapulohumeral muscular dystrophy (FSHD) is a neuromuscular disorder which is typically transmitted by an autosomal dominant pattern, although reduced penetrance and sporadic cases caused by mutations, are often observed. FSHD may be caused by a contraction of a repetitive element, located on chromosome 4 (4q35). This locus is named and consists of 11 to more than 100 repeated units (RU). Read More