3,991 results match your criteria Exercise-Induced Asthma

Diagnosis and management of nasal obstruction in the athlete: a narrative review by subgroup 6 of the IOC Consensus Group on "Acute Respiratory Illness in the Athlete".

J Sports Med Phys Fitness 2021 Jun 22. Epub 2021 Jun 22.

Sport, Exercise Medicine and Lifestyle Institute (SEMLI), Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa -

Protection of the health of the athlete is required for high level sporting performance. Acute respiratory illness is the leading cause of illness and can compromise training and competition in athletes. To date the focus on respiratory health in athletes has largely been on acute upper respiratory infections and asthma / exercise induced bronchoconstriction (EIB), while nasal conditions have received less attention. Read More

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Report of two cases of endobronchial tumour mass resection in children.

Can J Anaesth 2021 Jun 14. Epub 2021 Jun 14.

Department of Pediatric Anesthesia, Montreal Children's Hospital, 1001 Blvd Decarie, Montreal, QC, H4A 3J1, Canada.

Purpose: Anesthesia for endotracheal tumour mass resection in pediatric patients is a rare, complex, and high-risk procedure. The purpose of this case report is to emphasize the importance of multidisciplinary team collaboration and close communication during the perioperative management of shared airway surgery.

Clinical Features: A six-year-old boy with no previous history of comorbidity and a 13-yr-old boy with a six-month history of upper respiratory tract infection, refractory asthma, chronic wheeze, and exercise-related dyspnea presented for acute endobronchial tumour mass resection. Read More

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High Incidence of Bronchospastic Response to a Stair Climbing Exercise.

Cureus 2021 May 4;13(5):e14843. Epub 2021 May 4.

Institute of Sport Science and Innovations, Lithuanian Sports University, Kaunas, LTU.

Background While it is increasingly recognized that exercise-induced bronchoconstriction (EIB) affects a substantial proportion of sport participants, the relation of EIB incidence and severity to the type and intensity of exertion remains under-investigated. The aim of this study was to establish the incidence and severity of EIB during a stair race, a highly demanding all-out effort exercise. We hypothesized that a large proportion of participants would develop EIB to this particular high-intensity competition, and that among the predisposing factors, severity of EIB would depend on the level of exertion. Read More

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Comparison of physical fitness between healthy and mild-to-moderate asthmatic children with exercise symptoms: A cross-sectional study.

Pediatr Pulmonol 2021 Jun 1. Epub 2021 Jun 1.

Faculty of Sport Sciences, European University of Madrid, Madrid, Spain.

Objective: Asthma is a chronic disease that may affect physical fitness, although its primary effects on exercise capacity, muscle strength, functionality and lifestyle, in children and adolescents, are still poorly understood. This study aimed to evaluate the differences in cardiorespiratory fitness, muscle strength, lifestyle, lung function, and functionality between asthmatics with exercise symptoms and healthy children. In addition, we have analyzed the association between clinical history and the presence of asthma. Read More

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Decreasing ten-year (2008-2018) trends of the prevalence of childhood asthma and air pollution in Southern Taiwan.

World Allergy Organ J 2021 May 29;14(5):100538. Epub 2021 Apr 29.

Division of Allergy and Clinical Immunology, Department of Pediatrics, National Cheng Kung University Hospital, Tainan, Taiwan.

Background: Asthma is a common pediatric chronic respiratory disease worldwide. Previous studies showed the prevalence of childhood asthma increased in developed countries as well as in Taiwan in the late 20th century. Recently, several reports from different parts of the world showed a reversed trend in this epidemic of childhood asthma prevalence. Read More

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Evaluation of Diagnosis and Management of Omega-5-Gliadin Allergy: A Retrospective Survey.

J Asthma Allergy 2021 20;14:397-403. Epub 2021 Apr 20.

Allergy, Asthma & Clinical Immunology, Alfred Health, Melbourne, Victoria, Australia.

Background: Allergy to the omega-5-gliadin component of gluten (O-5-G allergy) often manifests when wheat ingestion is followed by a co-factor, usually exercise. There is no established best approach to management.

Objective: We sought to identify the beneficial effects, firstly of establishing a firm diagnosis, and secondly of stringent management, either by avoiding gluten ingestion altogether or separating it temporally from exercise by at least 4 hours. Read More

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[Vocal cord dysfunction in athletes: Interest of rehabilitation to effort].

Rev Mal Respir 2021 Apr 5;38(4):418-422. Epub 2021 Apr 5.

CIC-CRB 1404, unité de physiologie respiratoire et sportive, centre hospitalier universitaire de Rouen, 1, rue de Germont, 76000 Rouen, France.

Introduction: Vocal Cord Dysfunction (VCD) is a syndrome characterized by paradoxical adduction of the vocal folds during breathing. Its non-specific clinical manifestations frequently lead to misdiagnosis and delay in its treatment. The treatment of VCD is not pharmacological but rehabilitative and remains poorly appreciated. Read More

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Impulse oscillometry and free-running tests for diagnosing asthma and monitoring lung function in young children.

Ann Allergy Asthma Immunol 2021 Apr 2. Epub 2021 Apr 2.

Department of Allergology, Skin and Allergy Hospital, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.

Background: Separating individuals with viral-induced wheezing from those with asthma is challenging, and there are no guidelines for children under 6 years of age. Impulse oscillometry, however, is feasible in 4-year-old children.

Objective: To explore the use of impulse oscillometry in diagnosing and monitoring asthma in young children and evaluating treatment response to inhaled corticosteroid (ICS). Read More

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Asthma, atopy, and exercise: Sex differences in exercise-induced bronchoconstriction.

Exp Biol Med (Maywood) 2021 Apr 1:15353702211003858. Epub 2021 Apr 1.

Biobehavioral Laboratory, The University of North Carolina at Chapel Hill, School of Nursing, Chapel Hill, NC 27599, USA.

Asthma is a chronic inflammatory lung disease affecting approximately 7.7% of the US population. Sex differences in the prevalence, incidence, and severity of asthma have been widely described throughout the lifespan, showing higher rates in boys than girls before puberty, but a reversed pattern in adults. Read More

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Reciprocal Correlations of Inflammatory and Calcium Signaling in Asthma Pathogenesis.

Adv Exp Med Biol 2021 ;1303:319-331

Department of Molecular and Cellular Physiology, Albany Medical College, Albany, New York, USA.

Asthma is a chronic disease characterized by airway hyperresponsiveness, which can be caused by exposure to an allergen, spasmogen, or be induced by exercise. Despite its prevalence, the exact mechanisms by which the airway becomes hyperresponsive in asthma are not fully understood. There is evidence that myosin light-chain kinase is overexpressed, with a concomitant downregulation of myosin light-chain phosphatase in the airway smooth muscle, leading to sustained contraction. Read More

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Anaphylaxis in children and adolescents: The Portuguese Anaphylaxis Registry.

Pediatr Allergy Immunol 2021 Mar 27. Epub 2021 Mar 27.

Immunoallergy Department, Centro Hospitalar Lisboa Norte, Hospital Santa Maria, Lisbon, Portugal.

Background: Anaphylaxis is increasing at pediatric age; however, its characterization is hampered by underdiagnosis and underreporting. The aim of this study was to identify the causes of anaphylaxis in children and adolescents in Portugal, thus contributing to a better knowledge of its etiology, clinical manifestations, and management.

Methods: During a 10-year period, a nationwide notification system for anaphylaxis was implemented, with voluntary reporting by allergists. Read More

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A Boxed Warning for Montelukast: The FDA Perspective.

J Allergy Clin Immunol Pract 2021 Mar 17. Epub 2021 Mar 17.

Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Md.

The Food and Drug Administration (FDA) became aware of postmarketing reports of neuropsychiatric adverse events with Singulair (montelukast) use in 2007. Over the years, the FDA has conducted reviews of the clinical trial safety data, focused analyses of postmarketing reports, and reviews of the published literature. These activities have resulted in successive labeling updates and public communications. Read More

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[Induced asthma and sport].

Bruno Chenuel

Rev Prat 2020 Nov;70(9):997-1004

Centre Universitaire de Médecine du Sport et Activité Physique Adaptée, CHRU de Nancy, Vandoeuvrelès- Nancy, France ; EA DevAH, Département de Physiologie, Université de Lorraine, Vandoeuvrelès- Nancy, France.

Induced asthma and sport. Asthma is a common condition and the symptoms can be particularly triggered by sports activity, exercise being a current stimulus of bronchoconstriction. Nevertheless, the therapeutic arsenal that physician has and the implementation of international recommendations, based on optimal control of asthma, allow for perfectly adapted care. Read More

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November 2020

Continuous positive airway pressure acutely increases exercise duration in children with severe therapy-resistant asthma: a randomized crossover trial.

World J Pediatr 2021 Apr 17;17(2):189-196. Epub 2021 Mar 17.

Laboratory of Pediatric Physical Activity, Centro Infant, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Av. Ipiranga, 6690, 2º andar, Porto Alegre, RS, CEP 90610-000, Brazil.

Background: Lower exercise tolerance is an important component of asthma and the possible effects of non-invasive ventilation on exercise capacity in individuals with severe therapy-resistant asthma (STRA) are unknown. This study aimed to evaluate the immediate effect of continuous positive airway pressure (CPAP) on exercise tolerance in children with STRA.

Methods: We performed a controlled, randomized, crossover clinical trial including subjects aged 6 to 18 years old diagnosed with STRA. Read More

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Overweight and exercise-induced bronchoconstriction - Is there a link?

Pediatr Allergy Immunol 2021 Mar 8. Epub 2021 Mar 8.

Skin and Allergy Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Background: The objective of this study was to evaluate the role of body mass index with regard to exercise performance, exercise-induced bronchoconstriction (EIB), and respiratory symptoms in 7- to 16-year-old children.

Methods: A total of 1120 outdoor running exercise challenge test results of 7- to 16-year-old children were retrospectively reviewed. Lung function was evaluated with spirometry, and exercise performance was assessed by calculating distance per 6 minutes from the running time and distance. Read More

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Pulmonary Function Testing in Work-Related Asthma: An Overview from Spirometry to Specific Inhalation Challenge.

Int J Environ Res Public Health 2021 02 26;18(5). Epub 2021 Feb 26.

Development, Adaptation and Disadvantage, Cardiorespiratory Regulations and Motor Control, Department of Physiology, University of Lorraine, F-54000 Nancy, France.

Work-related asthma (WRA) is a very frequent condition in the occupational setting, and refers either to asthma induced (occupational asthma, OA) or worsened (work-exacerbated asthma, WEA) by exposure to allergens (or other sensitizing agents) or to irritant agents at work. Diagnosis of WRA is frequently missed and should take into account clinical features and objective evaluation of lung function. The aim of this overview on pulmonary function testing in the field of WRA is to summarize the different available tests that should be considered in order to accurately diagnose WRA. Read More

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February 2021

Exercise-induced laryngeal obstruction: From clinical examination to continuous laryngoscopy during exercise.

Eur Ann Otorhinolaryngol Head Neck Dis 2021 Feb 20. Epub 2021 Feb 20.

Clinique Universitaire d'ORL et Chirurgie cervico-faciale, CHU Grenoble Alpes, BP 217, 38043 Grenoble Cedex 09, France; Faculté de médecine, Université Grenoble Alpes, Domaine de la Merci, BP 170, 38042 Grenoble Cedex 9, France; UGA/UMR/CNRS 5309/Inserm 1209, Institut pour l'Avancée des Biosciences, Site Santé Allée des Alpes, 38700 La Tronche, France. Electronic address:

The diagnosis of exercise-induced laryngeal obstruction (EILO) should be suspected when exercise triggers inspiratory stridor. EILO is common in adolescent populations and has a significant impact on sports. Identification of laryngeal obstruction during continuous laryngoscopy during exercise (CLE) is the gold standard diagnostic tool for this disorder, which is not widely known in France. Read More

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February 2021

Comparative analysis between available challenge tests in the hyperventilation syndrome.

Respir Med 2021 04 12;179:106329. Epub 2021 Feb 12.

Department of Pulmonology, Jolimont Hospital, 159 Rue Ferrer, 7100, La Louvière, Belgium.

Background: The hyperventilation syndrome (HVS) is characterized by somatic/ psychological symptoms due to sustained hypocapnia and respiratory alkalosis without any organic disease.

Objective: The purpose of this study was to compare ventilatory parameters and symptoms reproducibility during the hyperventilation provocation test (HVPT) and cardiopulmonary exercise test (CPET) as diagnostic tools in patients with HVS, and to identify the most frequent etiologies of the HVS by a systematic assessment.

Methods: After exclusion of organic causes, 59 patients with HVS according to Nijmegen's questionnaire (NQ) score ≥23 with associated hypocapnia (PaCO/PET<35 mm Hg) were studied. Read More

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Failure to meet extubation criteria in the setting of suspected buffalo chest physiology.

Anaesth Rep 2021 Jan-Jun;9(1):32-36. Epub 2021 Feb 7.

Department of Anesthesiology and Critical Care Medicine Johns Hopkins University School of Medicine Baltimore MD USA.

We report the case of a patient who failed to meet tracheal extubation criteria due to low tidal volumes from suspected buffalo chest, which is a single pleural space physiology. This presentation followed the resection of a large pleural mass in a 59-year-old woman with a history of exercise-induced asthma, hypertension and tumour-related chronic respiratory failure. Creation of a pleuro-pleural communication during the resection of this large, unilateral pleural mass led to bilateral pneumothoraces and contributed to patients inability to generate negative inspiratory force leading to failure to meet extubation criteria. Read More

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February 2021

Current Asthma Management Practices by Primary School Teaching Staff: A Systematic Review.

J Sch Health 2021 03;91(3):227-238

Associate Professor, University of Malta, MSD 2080, Msida, Malta.

Background: The likelihood of children with asthma experiencing an exacerbation at school is significantly high when considering that they spend a substantial part of their day at school. This study, therefore, aimed to systematically review the literature to determine current asthma management practices by primary school teaching staff and any existing supporting legislation/policies/guidelines.

Methods: Search terms were adapted to search literature across databases: CINAHL, Cochrane Library, Education Database-ProQuest, IPA, MEDLINE, SCI. Read More

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Exercise Limitation in Children and Adolescents With Severe Refractory Asthma: A Lack of Asthma Control?

Front Physiol 2020 26;11:620736. Epub 2021 Jan 26.

Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.

Background: Patients with severe refractory asthma (SRA), even when using high doses of multiple controller medications in a regular and appropriate way, can have persistent complaints of exercise limitation.

Methods: This was a cross-sectional study involving patients with SRA (treated with ≥ 800 μg of budesonide or equivalent, with ≥ 80% adherence, appropriate inhaler technique, and comorbidities treated), who presented no signs of a lack of asthma control other than exercise limitation. We also evaluated healthy controls, matched to the patients for sex, age, and body mass index. Read More

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January 2021

Exercise-induced alterations in phospholipid hydrolysis, airway surfactant, and eicosanoids and their role in airway hyperresponsiveness in asthma.

Am J Physiol Lung Cell Mol Physiol 2021 05 3;320(5):L705-L714. Epub 2021 Feb 3.

Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of Washington, Seattle, Washington.

The mechanisms responsible for driving endogenous airway hyperresponsiveness (AHR) in the form of exercise-induced bronchoconstriction (EIB) are not fully understood. We examined alterations in airway phospholipid hydrolysis, surfactant degradation, and lipid mediator release in relation to AHR severity and changes induced by exercise challenge. Paired induced sputum ( = 18) and bronchoalveolar lavage (BAL) fluid ( = 11) were obtained before and after exercise challenge in asthmatic subjects. Read More

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Asthma medication in athletes: a qualitative investigation of adherence, avoidance and misuse in competitive sport.

J Asthma 2021 Mar 8:1-12. Epub 2021 Mar 8.

Carnegie School of Sport, Leeds Beckett University, Leeds, UK.

Objectives: The purpose of this qualitative study was to utilize the Capability, Opportunity, Motivation - Behavior model (COM-B) to: (1) evaluate athlete knowledge and understanding of current asthma-related anti-doping regulations, (2) explore the impact of environmental and societal influences on athletes with asthma, and (3) examine athlete perception of asthma medication use in competitive sport. Semi-structured interviews were conducted with ten competitive endurance athletes (five athletes with asthma and five without asthma). Interviews were guided by the COM-B model and transcripts were analyzed inductively and deductively using reflexive thematic analysis. Read More

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Diagnostic value of bronchoprovocation challenge with adenosine monophosphate versus exercise testing in early diagnosis of asthma.

Med J Armed Forces India 2021 Jan 21;77(1):46-50. Epub 2020 Mar 21.

Professor and Consultant (Medicine &Pulmonology), Command Hospital (Air Force), Bengaluru, India.

Background: Airway hyperresponsiveness (AHR) is a characteristic feature of bronchial asthma and is diagnosed using direct and indirect bronchoprovocation tests. The diagnosis of AHR is a challenge in symptomatic patients with a normal baseline prebronchodilator spirometry and postbronchodilator spirometry. Exercise-induced asthma or exercise-induced bronchoconstriction (EIB) is a distinct form of AHR. Read More

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January 2021

Prevalence of Asthma Symptoms in 13-14-Year-Old Adolescents in Karaj.

Iran J Allergy Asthma Immunol 2020 Dec 19;19(6):660-666. Epub 2020 Dec 19.

Non-Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran AND Department of Pediatrics, Imam Ali Hospital, Alborz University of Medical Sciences, Karaj, Iran.

Asthma is the most common chronic inflammatory respiratory disorder in children. This study was designed to assess the prevalence of asthma in 13-14-year-old adolescents in Karaj, Alborz province in Iran, using the international study of asthma and allergies in childhood (ISAAC) questionnaire. Totally 950 adolescents attending 40 schools located in 4 regions of Karaj city were enrolled in the survey. Read More

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December 2020

Drugs for asthma.


Med Lett Drugs Ther 2020 12;62(1613):193-200

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December 2020

The impact of mental toughness and postural abnormalities on dysfunctional breathing in athletes.

J Asthma 2021 Jan 25:1-15. Epub 2021 Jan 25.

Race Ready Coaching, Boulder, CO, USA.

While asthma and exercise-induced bronchoconstriction (EIB) can explain some cases of exertional dyspnea, the differential diagnosis of dyspnea is extensive. Dysfunctional breathing (DB) is a condition that is often overlooked and underdiagnosed. Pharmacologic treatments are available and widely utilized by clinicians for exertional dyspnea, but a better understanding of the non-pharmacologic treatments as well as psychological factors that play a role in DB can provide professional, elite amateurs, and recreational athletes with more therapeutic options. Read More

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January 2021

Ventilatory responses to constant load exercise following the inhalation of a short-acting ß-agonist in a laboratory-controlled diesel exhaust exposure study in individuals with exercise-induced bronchoconstriction.

Environ Int 2021 01 4;146:106182. Epub 2020 Dec 4.

School of Kinesiology, University of British Columbia, Vancouver, Canada; Faculty of Medicine, University of British Columbia, Vancouver, Canada.

Objective: Individuals with exercise-induced bronchoconstriction (EIB) use ß-agonists to reduce respiratory symptoms during acute exercise. The resultingbronchodilation could increase the dose of inhaled pollutants and impair respiratory function when exercise is performedin air pollution. We aimed to assess respiratory responses in individuals with EIB when completing a cycling bout while being exposed to diesel exhaust (DE) or filtered air (FA) with and without the inhalation of salbutamol (SAL), a short-acting ß-agonist. Read More

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January 2021

Exercise in Sub-zero Temperatures and Airway Health: Implications for Athletes With Special Focus on Heat-and-Moisture-Exchanging Breathing Devices.

Front Sports Act Living 2020 28;2:34. Epub 2020 Apr 28.

Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.

Asthma is highly prevalent among winter endurance athletes. This "occupational disease" of cross-country skiers, among others, was acknowledged during the 1990s, with the pathogenesis attributed to repeated and prolonged exposure to cold, dry air combined with high rates of ventilation during exercise. Nevertheless, more than 25 years later, the prevalence of asthma among Scandinavian cross-country skiers is unchanged, and prevention remains a primary concern for sports physicians. Read More

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Low-dose chlorine exposure impairs lung function, inflammation and oxidative stress in mice.

Life Sci 2021 Feb 15;267:118912. Epub 2020 Dec 15.

Public Employee of Sao Paulo Hospital (IAMSPE), Sao Paulo, Brazil; Department of Medicine (LIM 20), School of Medicine, University of Sao Paulo (FMUSP), Sao Paulo, Brazil; University City of Sao Paulo (UNICID), Sao Paulo, Brazil. Electronic address:

Aim: To explore the different consequences of acute and chronic exposure to chlorine gas (Cl) on the functional and histological parameters of health mice.

Main Methods: Firstly, male BALB/c mice were acute exposed to 3.3 or 33. Read More

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February 2021