1,269 results match your criteria Ewing Sarcoma and Primitive Neuroectodermal Tumors


Peripheral Primitive Neuroectodermal Tumor of the Ovary: The Report of Two Rare Cases.

Iran J Pathol 2018 25;13(4):467-470. Epub 2018 Sep 25.

APCP, Dept. of Anatomical and Surgical Pathology, Cancer Institute, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.

Peripheral primitive neuroectodermal tumor (pPNET) is a highly aggressive small round cell tumor belonging to PNET/Ewing sarcoma family. Ovarian tumors composed of primitive neuroectodermal elements are extremely rare. Herein we reported two cases of peripheral primitive neuroectodermal tumors of ovary in two patients with different clinical presentations. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358556PMC
September 2018

[Primary extra-osseous Ewing sarcoma of the dorsal spine with spinal cord compression at diagnosis: Case report].

Arch Argent Pediatr 2019 02;117(1):e41-e46

Grupo de Investigación en Salud del Adulto Mayor, Facultad de Ciencias de la Salud, Corporación Universitaria Remington, Medellín. Colombia.

Extraosseous primitive neuroectodermal tumors are very rare neoplasms. Only a few cases have been published in the literature. This report is about a 9-year-old female patient whose clinical manifestations showed spinal cord compression, so different diagnosis should be considered, including oncology disease. Read More

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http://dx.doi.org/10.5546/aap.2019.e41DOI Listing
February 2019
4 Reads

Primary Intra-abdominal Ewing's Sarcoma in Adults: A Multimodality Imaging Spectrum.

Curr Probl Diagn Radiol 2019 Jan 2. Epub 2019 Jan 2.

Department of Radiology, UW Medicine, Seattle, WA. Electronic address:

Ewing sarcoma (ES) and peripheral primitive neuroectodermal tumor are part of a spectrum of neoplastic diseases known as the ES family of tumors, which also includes extraosseous ES, peripheral primitive neuroectodermal tumor, malignant small-cell tumor of the thoracopulmonary region (Askin's tumor), and atypical ES. Although imaging features of these tumors have been previously described, extensive discussion about intra-abdominal manifestations is scarce in the literature. We present an imaging spectrum of these tumors in the abdomen and pelvis with particular attention to multimodality approach for staging and restaging. Read More

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http://dx.doi.org/10.1067/j.cpradiol.2018.12.009DOI Listing
January 2019
1 Read

Pazopanib Confers a Progression-free Survival in a Patient with Ewing's Sarcoma/Primitive Neuroectodermal Tumor of the Lung.

Intern Med 2019 Jan 10. Epub 2019 Jan 10.

Division of Pulmonary Medicine, Department of Medicine, Jichi Medical University, Japan.

Ewing's sarcoma (ES)/primitive neuroectodermal tumors (PNETs) are highly malignant neoplasms that usually affect the bones and soft tissues in children and young adults. ES/PNET of the lung is very rare and is associated with a poor prognosis. We herein report a case of ES/PNET of the left lung in a 45-year-old man. Read More

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http://dx.doi.org/10.2169/internalmedicine.1549-18DOI Listing
January 2019
3 Reads

Comparison of clinical features and outcomes in patients with extraskeletal vs skeletal Ewing sarcoma: an SEER database analysis of 3,178 cases.

Cancer Manag Res 2018 23;10:6227-6236. Epub 2018 Nov 23.

Department of Medical Oncology, The Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China,

Background: The clinicopathological characteristics, outcomes and prognostic factors of primary extraskeletal Ewing sarcoma (EES) remained insufficiently explored. We aimed to examine these aspects and compared the same with skeletal Ewing sarcoma (SES).

Patients And Methods: We identified Ewing sarcoma, peripheral primitive neuroectodermal tumors or Askin tumor patients who were registered in the Surveillance, Epidemiology, and End Results database from 1973 to 2014. Read More

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http://dx.doi.org/10.2147/CMAR.S178979DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260126PMC
November 2018
2 Reads

Clinical Features and Long-Term Outcome of Primary Intracranial Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumors: 14 Cases From a Single Institution.

World Neurosurg 2019 Feb 26;122:e1606-e1614. Epub 2018 Nov 26.

Department of Neurosurgery, Tongji Hospital, Tongji Medical School, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China. Electronic address:

Objective: Primary intracranial Ewing sarcoma (ES)/peripheral primitive neuroectodermal tumors (pPNETs) are extremely rare, and only a few studies have reported >4 cases of this disease. The purpose of this study was to explore the clinical features, treatment, and outcome of primary intracranial ES/pPNETs.

Methods: The clinical data of 14 patients who had been surgically treated from February 2003 to November 2017 and in whom immunohistochemical staining results had confirmed the diagnosis of primary intracranial ES/pPNETs were retrospectively analyzed. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.11.151DOI Listing
February 2019
1 Read

Ewing's sarcoma of kidney in a 60-year-old patient with local recurrence: A rare occurrence.

J Cancer Res Ther 2018 Oct-Dec;14(6):1422-1424

Department of Medical Oncology, Gazi University Faculty of Medicine, Ankara, Turkey.

Ewing's family of tumors is aggressive tumors and frequently arises from bone and soft tissue. They might also arise from nonosseous structures such as gastrointestinal tract, adrenal glands, or kidney. Primary renal Ewing's sarcoma (ES)/primitive neuroectodermal tumor is an extremely rare entity which has aggressive clinical course. Read More

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http://dx.doi.org/10.4103/0973-1482.191062DOI Listing
February 2019
1 Read

Renal Ewing sarcoma/primitive neuroectodermal tumor in a pregnant woman who underwent robot-assisted laparoscopic nephrectomy: a case report and literature review.

Onco Targets Ther 2018 11;11:6839-6843. Epub 2018 Oct 11.

State Key Laboratory of Reproductive Medicine and Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, People's Republic of China,

Primary Ewing sarcoma/primitive neuroectodermal tumor (ES/PNET) of the kidney represents a spectrum of rare neoplasm with dismal clinical prognosis. This type of malignant tumor predominantly occurs in the soft tissue and bones of pediatric-young adults, and it may rarely arise from the kidney. Derived from the neuroectoderm, renal ES/PNET belongs to a group of primitive and aggressive tumors in its biological manifestation. Read More

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https://www.dovepress.com/renal-ewing-sarcomaprimitive-neuro
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http://dx.doi.org/10.2147/OTT.S155523DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6188190PMC
October 2018
6 Reads

Rearrangement and CD99 Expression as Diagnostic Biomarkers for Ewing/PNET Sarcomas in a Moroccan Population.

Dis Markers 2018 18;2018:7971019. Epub 2018 Sep 18.

Pathological Anatomy and Molecular Pathology Department, Hassan II University Hospital of Fez, Morocco.

Ewing sarcoma/primitive neuroectodermal tumor (Ewing/PNET sarcomas or EPS) are a group of round cell tumors. Malignant round cell tumors form a large and diverse group that includes rhabdomyosarcoma, synovial sarcoma, non-Hodgkin's lymphoma, neuroblastoma, hepatoblastoma, Wilm's tumor, desmoplastic small round cell tumor, and other morphologically similar entities. Differential diagnosis of Ewing sarcoma/primitive neuroectodermal tumor (Ewing/PNET sarcomas or EPS) is difficult. Read More

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https://www.hindawi.com/journals/dm/2018/7971019/
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http://dx.doi.org/10.1155/2018/7971019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167566PMC
January 2019
6 Reads

Ewing's Sarcoma/Peripheral Primitive Neuroectodermal Tumors in Bronchus.

Am J Med Sci 2019 Jan 22;357(1):75-80. Epub 2018 Aug 22.

Department of Medical imaging, The Second Hospital of Hebei Medical University, Shijiazhuang, China. Electronic address:

Ewing sarcoma/peripheral primitive neuroectodermal tumors (ES/pPNET), a member of the Ewing sarcoma family of tumors, is a malignant soft tissue tumor with small undifferentiated neuroectodermal cells. Primary trachea-bronchial ES/pPNET is very rare. The most common pulmonary ES is due to a metastasis. Read More

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http://dx.doi.org/10.1016/j.amjms.2018.08.009DOI Listing
January 2019
8 Reads

From Ataxia to Diagnosis of Askin Tumor - a Case Report.

Acta Medica (Hradec Kralove) 2018;61(2):60-64

University of Zagreb, School of Medicine, Zagreb, Croatia.

Peripheral primitive neuroectodermal tumors (pPNET) are a group of extremely rare, aggressive, malignant tumors that are most often found in the thorax (Askin tumor), abdomen, pelvis, extremities and less frequently in the head and neck. The most important prognostic factor is the stage of the tumor. Significant progress both in surgery and in neoadjuvant and adjuvant chemotherapy and radiotherapy, as well as the improvement in diagnosis by cytogenetic and immunohistochemical analysis, should improve the survival rate. Read More

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http://dx.doi.org/10.14712/18059694.2018.53DOI Listing
December 2018
9 Reads

Comparison of Epidemiology, Clinical Features, and Outcomes of Patients with Reported Ewing Sarcoma and PNET over 40 Years Justifies Current WHO Classification and Treatment Approaches.

Sarcoma 2018 8;2018:1712964. Epub 2018 Aug 8.

Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Harvard Medical School, Boston, MA, USA.

Background: As of 2013, the WHO has classified peripheral primitive neuroectodermal tumors (PNETs) within the umbrella of Ewing sarcoma family of tumors (ESFTs) given their shared biology. Histologic features differ between PNET and Ewing sarcoma (ES), and potential clinical differences between PNET and ES have not been fully elucidated.

Methods: Through the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) database, we identified 3,575 patients identified with histologic diagnosis of ES or PNET from 1973 to 2014. Read More

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http://dx.doi.org/10.1155/2018/1712964DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109476PMC
August 2018
2 Reads

Primary Ewing Family of Tumor Arising in the Ovary: A Case Report.

Int J Gynecol Pathol 2018 Aug 6. Epub 2018 Aug 6.

Department of Obstetrics and Gynecology (Y.-P.L., S.-P.L., C.-A.C., W.-F.C.) Pathology (K.C.) Oncology (T.W.-W.C.) Graduate Institute of Oncology (W.-F.C.) Graduate Institute of Clinical Medicine, College of Medicine (W.-F.C.), National Taiwan University Department of Obstetrics and Gynecology, Shin-Kong Memorial Wu Ho-Su Hospital (Y.-P.L.), Taipei, Taiwan.

Ewing sarcoma and peripheral primitive neuroectodermal tumor constitute the Ewing family of tumors (EFT). EFTs primarily arising in the ovary are extremely rare. We report the case of a 22-yr-old nulliparous woman with a primary EFT in the ovary that initially presented as a 3-cm teratoma-like ovarian tumor, with rapid progression to a 15-cm-sized tumor with liver metastasis in 3 mo. Read More

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http://dx.doi.org/10.1097/PGP.0000000000000536DOI Listing
August 2018
14 Reads

Staging and following common pediatric malignancies: MRI versus CT versus functional imaging.

Authors:
Stephan D Voss

Pediatr Radiol 2018 08 4;48(9):1324-1336. Epub 2018 Aug 4.

Department of Radiology, Boston Children's Hospital, Harvard Medical School, 300 Longwood Ave., Boston, MA, 02115, USA.

Most pediatric malignancies require some form of cross-sectional imaging, either for staging or response assessment. The majority of these are solid tumors and this review addresses the role of MRI, as well as other cross-sectional and functional imaging techniques, for evaluating the most common pediatric solid tumors. The primary emphasis is on neuroblastoma, hepatoblastoma and Wilms tumor, three of the most common non-central-nervous-system (CNS) pediatric solid tumors encountered in young children. Read More

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http://dx.doi.org/10.1007/s00247-018-4162-4DOI Listing
August 2018
5 Reads

Ewing-Like Sarcoma: A Case of a Primary Cutaneous Primitive Neuroectodermal Tumor With Atypical Immunohistochemistry and Lack of Fusion Oncogene Detection.

Am J Dermatopathol 2018 Dec;40(12):890-893

Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, IL.

We present a 25-year-old male patient with a primary cutaneous primitive neuroectodermal tumor (cPNET) with unusual immunohistochemistry and lack of fusion oncogene generation. The lesion expressed CD99 and WT-1, and the histological features were consistent with cPNET. Differential diagnoses such as rhabdomyosarcoma, desmoplastic small round blue cell tumor, hematolymphoid neoplasm, neuroblastoma, and CIC-DUX round cell sarcoma were ruled out based on immunohistochemistry, genetic studies, and histology. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001237DOI Listing
December 2018
7 Reads
1.430 Impact Factor

Adjuvant chemotherapy for a primitive neuroectodermal tumor of the uterine corpus: A case report and literature review.

J Obstet Gynaecol Res 2018 Oct 26;44(10):2008-2015. Epub 2018 Jul 26.

Department of Pathology, National Kyushu Cancer Center, Fukuoka, Japan.

A primitive neuroectodermal tumor (PENT) belongs to the category of a Ewing sarcoma. A PENT of the uterus is rare and has been known to be very aggressive by nature. Owing to the rarity of the tumor, there is no optimal treatment at present. Read More

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http://dx.doi.org/10.1111/jog.13753DOI Listing
October 2018
6 Reads

Molecular assessment of circulating exosomes toward liquid biopsy diagnosis of Ewing sarcoma family of tumors.

Transl Res 2018 11 23;201:136-153. Epub 2018 Jun 23.

Department of Chemistry, University of Kansas, Lawrence, Kansas; University of Kansas Cancer Center, Kansas City, Kansas. Electronic address:

Ewing sarcoma was first described in 1921 in the Proceedings of the New York Pathological Society by an eminent American pathologist from Cornell named James R. Ewing as a "diffuse endothelioma of bone." Since this initial description, more has been discovered regarding Ewing sarcoma and in the 1980's both Ewing sarcoma and peripheral primitive neuroectodermal tumors due to their similar features and shared identical genetic abnormality were grouped into a class of cancers entitled Ewing sarcoma family of tumors (ESFTs). Read More

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http://dx.doi.org/10.1016/j.trsl.2018.05.007DOI Listing
November 2018
4 Reads

Ewing Sarcoma and the History of Similar and Possibly Related Small Round Cell Tumors: From Whence Have We Come and Where are We Going?

Adv Anat Pathol 2018 Sep;25(5):314-326

Department of Anatomic Pathology/L25, Cleveland Clinic, Cleveland, OH.

The diagnosis of small round cell tumors always has been extremely difficult, and our current classification systems continue to evolve. Since its initial discovery by Dr James Ewing, the historical context of what is acceptably included under the designation "Ewing sarcoma" has changed. Although Ewing sarcoma and primitive neuroectodermal tumor were both initially described in the early 20th century, these tumors were considered likely distinct entities until the end of that same century, almost 75 years later. Read More

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http://dx.doi.org/10.1097/PAP.0000000000000203DOI Listing
September 2018
12 Reads

Peripheral primitive neuroendocrine tumor of the chest wall-A case report with pathological correlation.

Radiol Case Rep 2018 Apr 5;13(2):392-396. Epub 2018 Feb 5.

Tufts Medical Center, 800 Washington St, Boston, MA 02111, USA.

Primitive neuroectodermal tumor is a high-grade malignant tumor originating from the neural crest and neuroectoderm, which can be subdivided into central and peripheral categories. Peripheral primitive neuroectodermal tumor is thought to be identical to Ewing's sarcoma, and falls under a broader category of Ewing's sarcoma family of tumors. Very rarely, it may present without osseous involvement, known as extraosseous Ewing's sarcoma. Read More

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http://dx.doi.org/10.1016/j.radcr.2018.01.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6000041PMC
April 2018
6 Reads

Metachronous renal Ewing sarcoma/primitive neuroectodermal tumour in a survivor of Burkitt lymphoma.

BMJ Case Rep 2018 Jun 11;2018. Epub 2018 Jun 11.

Department of Pathology and Laboratory Medicine, Aga Khan University, Karachi, Pakistan.

We present a case of a 14-year-old girl who was diagnosed with Burkitt lymphoma in 2014. She was managed with chemotherapy and remained in remission for 3 years. On her surveillance imaging in 2017, a left-sided renal neoplastic mass was incidentally discovered. Read More

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http://dx.doi.org/10.1136/bcr-2017-224071DOI Listing
June 2018
8 Reads

Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor in the Adrenal Gland of a Child.

Iran J Kidney Dis 2018 05;12(3):190-192

Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Ewing sarcoma/peripheral primitive neuroectodermal tumor (ES/PNET) typically occurs in long or flat bones, soft tissues, or less often, solid organs. Ewing sarcoma/peripheral primitive neuroectodermal tumor arising from the adrenal gland is extremely rare, especially in children, and only limited cases are reported previously. Herein, we review a case of a 22-month-old girl who presented to our department with abdominal pain, bulging of the left flank, and a nonfunctioning adrenal lesion which was found to be an adrenal ES/PNET. Read More

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May 2018
5 Reads

Primary Spinal Intradural Extraosseous Ewing Sarcoma in a Pediatric Patient: Case Report and Review of the Literature.

Pediatr Neurosurg 2018 25;53(4):222-228. Epub 2018 May 25.

Pediatric Oncology and Hematology, Indiana University Health, Indianapolis, Indiana, USA.

Ewing sarcoma (ES) is an aggressive, primary bone malignancy with occasional soft tissue extension. Purely extra-osseous ES is rare. A primary intraspinal, intradural ES without bone involvement is exceedingly rare. Read More

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http://dx.doi.org/10.1159/000488767DOI Listing
September 2018
1 Read

Primary Intracranial pPNET/Ewing Sarcoma: Diagnosis, Management, and Prognostic Factors Dilemma-A Systematic Review of the Literature.

World Neurosurg 2018 Jul 3;115:346-356. Epub 2018 May 3.

Department of Neurosurgery, Mohamed V Military Hospital, Rabat, Morocco.

Background: Ewing sarcoma (ES) is a malignant bone tumor that is most commonly observed in the long bones, the pelvis, and the chest. Primary intracranial localization is extremely rare.

Objective: In the aim of identifying the prognostic factors of this rare localization, we conducted a systematic review of the literature for patients with primary intracranial peripheral primitive neuroectodermal tumor/ES. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.04.164DOI Listing
July 2018
9 Reads
2.420 Impact Factor

Insulin-like growth factor-1 receptor expression in pediatric tumors: a comparative immunohistochemical study

Turk J Med Sci 2018 Apr 30;48(2):419-423. Epub 2018 Apr 30.

Background/aim: Insulin-like growth factor-1 receptor (IGF-1R) is a pivotal receptor tyrosine kinase involved in the cell cycle and malignant tumor transformation. It is differentially expressed in various types of tumors. We aimed to determine the expression of IGF- 1R in different pediatric tumors and to shed light on possible new indications of anti-IGF-1R treatment approaches. Read More

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http://dx.doi.org/10.3906/sag-1801-233DOI Listing
April 2018
14 Reads

A mesenteric primary peripheral Ewing's sarcoma/primitive neuroectodermal tumor with molecular cytogenetic analysis: Report of a rare case and review of literature.

Indian J Pathol Microbiol 2018 Apr-Jun;61(2):248-251

Department of Surgery, Division of Plastic and Reconstructive Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC.

Rare cases of Ewing's sarcoma/primitive neuroectodermal tumors (EWS/PNETs) arising from mesenteric tissue have been reported. This report describes an EWS/PNET in a 25-year-old woman who presented with abdominal pain lasting 3 days. Radiologic evaluation revealed a 9 cm × 6 cm homogeneous mass in the lower abdomen with homogeneous enhancement and invasion of the ileum. Read More

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http://dx.doi.org/10.4103/IJPM.IJPM_546_17DOI Listing
October 2018
1 Read

Sinonasal Ewing Sarcoma: A Case Report and Literature Review.

Perm J 2018 03;22

Otolaryngologist in the Department of Head and Neck Surgery at the Oakland Medical Center in CA.

Introduction: Ewing sarcoma (ES) of the sinonasal tract and associated primitive neuroectodermal tumors are rare. To our knowledge, only 10 case reports of sinonasal ES of the nose or paranasal sinuses have been reported. Furthermore, there has been only 1 case of sinonasal ES arising from the middle turbinate. Read More

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http://dx.doi.org/10.7812/TPP/17-086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5882178PMC
March 2018
2 Reads

Extra-osseous Ewing sarcoma of the pancreas: case report with radiologic, pathologic, and molecular correlation, and brief review of the literature.

Virchows Arch 2018 Sep 2;473(3):361-369. Epub 2018 Apr 2.

Department of Pathology, Northwell Health, 6 Ohio Drive, suite 202, Lake Success, NY, 11042, USA.

In 2002, due to extensive histomorphologic, immunohistochemical, and cytogenetic similarities, the World Health Organization unified undifferentiated small round blue cell neoplasms of soft tissue and bone (previously segregated as Ewing sarcoma or Primitive Neuroectodermal tumor) into one category: Ewing family of tumors (EFT). Osseous EFT are more common, and while extra-osseous EFT can occur anywhere in the body, those of the pancreas are rare and likely to be seen in the second decade of life in the head of the pancreas. We report the case of a 39-year-old Caucasian male with a large heterogeneously enhancing mass in the pancreatic body. Read More

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http://link.springer.com/10.1007/s00428-018-2344-y
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http://dx.doi.org/10.1007/s00428-018-2344-yDOI Listing
September 2018
11 Reads

Adrenal mass of unusual etiology: Ewing sarcoma in a young man.

Radiol Case Rep 2017 Dec 31;12(4):838-844. Epub 2017 Jul 31.

Department of Oncology, Haydarpasa Numune Research and Educational Hospital, Istanbul, Turkey.

Ewing sarcoma and peripheral primitive neuroectodermal tumor belong to the Ewing sarcoma (ES) family of tumors originating from a primitive neural tube. We report a 31-year-old man who was admitted to the urology clinic with complaints of fever, nausea, and dysuria. A right-sided adrenal mass was detected during ultrasonography. Read More

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http://dx.doi.org/10.1016/j.radcr.2017.07.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5823311PMC
December 2017
8 Reads

[Ewing sarcomas and Ewing-like sarcomas : New aspects].

Authors:
K Specht W Hartmann

Pathologe 2018 Mar;39(2):154-163

Gerhard-Domagk-Institut für Pathologie, Universitätsklinikum Münster, Münster, Deutschland.

Sarcomas of the Ewing family of tumors are aggressive neoplasms occurring in bone and soft tissue of mostly children and young adults. Classical Ewing sarcomas are pathognomonically characterized by fusions between a gene of the RNA-binding TET family (EWSR1 or FUS) with a gene of the ETS-transcription family (FLI1, ERG, ETV1, ETV4 or FEV). Less frequent cases designated as Ewing-like sarcomas show different genetic rearrangements between EWSR1 and non-ETS genes (NFATC2, POU5F1, SMARCA5, PATZ, ZSG, SP3). Read More

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http://dx.doi.org/10.1007/s00292-018-0421-2DOI Listing
March 2018
3 Reads

[Neuroendocrine neoplasms of the auditory, olfactory, and visual sensory organs].

Authors:
B Sipos

Pathologe 2018 May;39(3):255-263

Institut für Allgemeine Pathologie und Neuropathologie, Universitätsklinikum Tübingen, Liebermeisterstraße 8, 72076, Tübingen, Deutschland.

Neuroendocrine neoplasms (NENs) are infrequent in sensory organs. There are well-differentiated neuroendocrine neoplasms that should be classified as neuroendocrine tumors, in analogy to their gastrointestinal counterparts, however the nomenclature is inconsistent. The best defined entities are neuroendocrine tumors in the middle ear and ectopic pituitary adenoma in the sphenoid region. Read More

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http://dx.doi.org/10.1007/s00292-017-0411-9DOI Listing
May 2018
2 Reads

Antiangiogenic therapy for primitive neuroectodermal tumor with thalidomide: A case report and review of literature.

Medicine (Baltimore) 2017 Dec;96(51):e9272

Department of Oncology, Xuzhou Central Hospital Affiliated to Dongnan University, Xuzhou, Jiangsu, China.

Rationale: Peripheral primitive neuroectodermal tumor (PNET) is a kind of small round cell tumor derived from primitive neuroectodermal tumor.

Patient Concerns: PNET is a highly malignant tumor that is subordinated to Ewing sarcoma. It occurs predominantly in soft tissue and bone and rarely in the bronchi and lung. Read More

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http://dx.doi.org/10.1097/MD.0000000000009272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5758187PMC
December 2017
26 Reads

Extraosseous Ewing's Sarcoma of the Pancreas: An Uncommon but Treatable Disease.

Cureus 2017 Nov 26;9(11):e1882. Epub 2017 Nov 26.

Cancer Center, Lexington Medical Center.

Extraosseous Ewing's sarcoma/primitive neuroectodermal tumor (ES/PNET) is a rare but aggressive and malignant tumor, and has been reported in various sites such as the lungs, biliary tract, kidney, prostate, stomach, esophagus, oral cavity, salivary glands, urinary bladder, uterus, cervix, gonads, and vagina. However, the pancreas is considered to be an extremely uncommon site and only a handful of cases have been published to date. We present here another case of a pancreatic ES/PNET. Read More

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http://dx.doi.org/10.7759/cureus.1882DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786351PMC
November 2017
1 Read

HDL nanoparticles targeting sonic hedgehog subtype medulloblastoma.

Sci Rep 2018 01 19;8(1):1211. Epub 2018 Jan 19.

Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Lurie 3-125, 303 E. Superior St., Chicago, IL, 60611, United States.

Medulloblastoma is the most common paediatric malignant brain cancer and there is a need for new targeted therapeutic approaches to more effectively treat these malignant tumours, which can be divided into four molecular subtypes. Here, we focus on targeting sonic hedgehog (SHH) subtype medulloblastoma, which accounts for approximately 25% of all cases. The SHH subtype relies upon cholesterol signalling for tumour growth and maintenance of tumour-initiating cancer stem cells (CSCs). Read More

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http://dx.doi.org/10.1038/s41598-017-18100-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5775338PMC
January 2018
2 Reads

Immunohistochemical Biomarkers of Mesenchymal Neoplasms in Endocrine Organs: Diagnostic Pitfalls and Recent Discoveries.

Endocr Pathol 2018 Jun;29(2):189-198

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.

Mesenchymal neoplasms rarely present in or adjacent to endocrine organs. In this context, the recognition of these rare tumor types can be challenging, with significant potential for misdiagnosis as sarcomatoid carcinomas (i.e. Read More

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http://dx.doi.org/10.1007/s12022-018-9513-zDOI Listing
June 2018
6 Reads

A Profile of Pediatric Solid Tumors: A Single Institution Experience in Kashmir.

Indian J Med Paediatr Oncol 2017 Oct-Dec;38(4):471-477

Department of Paediatric Surgery, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India.

Aims: The purpose of this retroprospective study was to study the epidemiological characteristics and outcomes of children with solid tumors at our institution.

Subjects And Methods: Three hundred and three pediatrics patients registered at Regional Cancer Centre (RCC), Sher-i-Kashmir Institute of Medical Sciences (SKIMS), Srinagar, Kashmir, between January 2008 and June 2014, were analyzed with regard to demographic status, presenting complaints, investigations, treatment, morbidity, and outcomes. Standard statistical methods were used for analysis. Read More

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http://dx.doi.org/10.4103/ijmpo.ijmpo_95_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5759067PMC
January 2018
11 Reads

Intracranial Ewing sarcoma: four pediatric examples.

Childs Nerv Syst 2018 Mar 28;34(3):441-448. Epub 2017 Dec 28.

Department of Neurosurgery, The University of Colorado School of Medicine, 12605 E. 16th Avenue, Aurora, CO, 80045, USA.

Background: Ewing sarcoma typically arises in bone and is unrelated to intraparenchymal small blue cell embryonal central nervous system (CNS) tumors previously designated primitive neuroectodermal tumors (PNETs). When the CNS is impacted, it is usually secondary to local extension from either the epidural space, skull, or intracranial or spinal metastases. Primary examples within the cranial vault are rare, usually dural-based, and are largely case reports in the literature. Read More

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http://dx.doi.org/10.1007/s00381-017-3684-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5808087PMC
March 2018
22 Reads

Metastatic Primitive Neuroectodermal Tumor of the Prostate: A Case Report and Review of the Literature.

Clin Genitourin Cancer 2018 04 7;16(2):e343-e347. Epub 2017 Nov 7.

Department of Radiology, University of Illinois at Chicago, Chicago, IL. Electronic address:

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http://dx.doi.org/10.1016/j.clgc.2017.10.023DOI Listing
April 2018
7 Reads

Characterization, survival analysis, and expression of IGFR in tumor samples from patients diagnosed with Ewing family tumors treated at the Barretos Cancer Hospital.

Rev Bras Ortop 2017 Nov-Dec;52(6):705-713. Epub 2016 Dec 31.

Hospital de Câncer Infanto-Juvenil de Barretos, Oncologia Pediátrica, Barretos, SP, Brazil.

Objectives: Study the clinical characteristics of patients diagnosed with Ewing family tumors (EFTs) and survival analysis based on risk criteria and expression of the surface protein known as insulin-like growth factor (IGFR).

Methods: This was a retrospective cohort study based on clinical data from 77 patients diagnosed with EFTs treated by the Department of Pediatric Oncology at the Barretos Cancer Hospital in a period between 2003 and 2012. Biological samples of patients were examined for the presence of the surface receptor IGFR. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22554971163015
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http://dx.doi.org/10.1016/j.rboe.2016.10.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5720841PMC
December 2016
6 Reads

Single institution experience on cancer among adolescents 15-19 years of age.

Turk J Pediatr 2017 ;59(1):1-5

Department of Pediatric Oncology, Hacettepe University Institute of Oncology, Ankara, Turkey.

Yağcı-Küpeli B, Akyüz C, Yalçın B, Varan A, Kutluk T, Büyükpamukçu M. Single institution experience on cancer among adolescents 15-19 years of age. Turk J Pediatr 2017; 59: 1-5. Read More

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http://dx.doi.org/10.24953/turkjped.2017.01.001DOI Listing
December 2017
8 Reads

Primary Ewing Sarcoma of the Thyroid-Eight Cases in a Decade: A Case Report and Literature Review.

Front Endocrinol (Lausanne) 2017 27;8:257. Epub 2017 Oct 27.

Department of Surgical Oncology, Medical University of Gdańsk, Gdańsk, Poland.

Sarcomas represent less than 1% of all malignant tumors found in the thyroid. Of these, primary extraosseoussarcoma has been reported only a few times in the past decade. We present the case of a 34-year-old male who had a fast-growing hard mass in the lower left neck. Read More

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http://dx.doi.org/10.3389/fendo.2017.00257DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663906PMC
October 2017
7 Reads

Adamantinoma-like Ewing sarcoma of the parotid gland: Cytopathologic findings and differential diagnosis.

Diagn Cytopathol 2018 Mar 16;46(3):263-266. Epub 2017 Oct 16.

Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21224.

Adamantinoma-like Ewing sarcoma (AES) is a rare variant of Ewing sarcoma family of tumors (EFTs), primarily affecting bone and soft tissue. AES has mixed features of Ewing sarcoma (ES)/primitive neuroectodermal tumor (PNET) and adamantinoma with a complex immunoprofile and EWSR1 gene rearrangements. Herein, we report a 72-year-old male who presented with left parotid mass, right neck mass and thyroid nodules. Read More

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http://dx.doi.org/10.1002/dc.23829DOI Listing
March 2018
8 Reads

Tissue-directed Implantation Using Ultrasound Visualization for Development of Biologically Relevant Metastatic Tumor Xenografts.

In Vivo 2017 Sep-Oct;31(5):779-791

Department of Surgery, C.S Mott Children's and Women's Hospital, Mott Solid Tumor Oncology Program, The University of Michigan Medical School, Ann Arbor, MI, U.S.A.

Background: Advances in cancer therapeutics depend on reliable in vivo model systems. To develop biologically relevant xenografts, ultrasound was utilized for tissue-directed implantation of neuroblastoma (NB) cell line and patient-derived tumors in the adrenal gland, and for renal subcapsular engraftment of Ewing's sarcoma (ES).

Materials And Methods: NB xenografts were established by direct adrenal injection of luciferase-transfected NB cell lines (IMR32, SH-SY5Y, SK-N-BE2) or NB patient-derived tumor cells (UMNBL001, UMNBL002). Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5656850PMC
May 2018
11 Reads

Post-Chemotherapy Neuroblastoma-like Differentiation in Ewing Sarcoma of Humerus: Report of a Rare Case with Review of Literature.

J Coll Physicians Surg Pak 2017 Jul;27(7):444-446

Department of Pathology and Laboratory Medicine, The Aga Khan University Hospital, Karachi.

A21-year patient initially presented with a fracture of the humerus following minor trauma. Abone scan and biopsy were done due to the suspicion of pathological fracture and the biopsy confirmed the diagnosis of Ewing Sarcoma (EWS). Two months after initial presentation, chemotherapy was started and 5 cycles were given over a span of 6 months. Read More

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http://dx.doi.org/2662DOI Listing
July 2017
9 Reads

Rare Ileal Ewing Sarcoma/Primitive Neuroectodermal Tumor on 18F-FDG PET/CT.

Clin Nucl Med 2017 Oct;42(10):809-811

From the Departments of *Nuclear Medicine, and †Pathology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.

A 24-year-old woman who had melena, dizziness, and fatigue and looked pale for 2 months was confirmed to have a microcytic hypochromic anemia in the local hospital. It was further revealed that the patient had splenomegaly and a small intestinal lump, and she was then referred to our hospital. The enhanced CT showed an ileal lesion with enhancement, which showed an increased F-FDG activity in further PET/CT scanning. Read More

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http://dx.doi.org/10.1097/RLU.0000000000001788DOI Listing
October 2017
7 Reads

Ewing Sarcoma of the Cervical Epidural Space Presenting with Tetraplegia: Case Report and Review of Literature.

World Neurosurg 2017 Nov 7;107:1046.e9-1046.e15. Epub 2017 Aug 7.

Department of Neurosurgery, Government Medical College, Thiruvananthapuram, Kerala, India.

Background: Ewing sarcoma (ES) is among the most frequented extremity osseous tumor in childhood. It was first described by James Ewing as diffuse endotheliomas in 1921. The name Ewing sarcoma was coined by Oberling in 1928 as a tribute to the legend who described this disease. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750173128
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http://dx.doi.org/10.1016/j.wneu.2017.07.182DOI Listing
November 2017
10 Reads

Primary intracranial dural-based Ewing sarcoma/peripheral primitive neuroectodermal tumor mimicking a meningioma: A rare tumor with review of literature.

Asian J Neurosurg 2017 Jul-Sep;12(3):351-357

Department of Pathology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.

Ewing sarcoma/peripheral primitive neuroectodermal tumor (ES/pPNET) is a malignant small, round cell tumor arising from bone and soft tissue in children and young adults. It can occur at osseous and extraosseous sites. Its usual locations are diaphysis of long bones followed by pelvis, ribs, vertebrae, and rarely skull. Read More

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http://dx.doi.org/10.4103/1793-5482.185060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5532914PMC
August 2017
17 Reads

The role of anaplastic lymphoma kinase in pediatric cancers.

Authors:
Junko Takita

Cancer Sci 2017 Oct 24;108(10):1913-1920. Epub 2017 Aug 24.

Department of Pediatrics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

The anaplastic lymphoma kinase (ALK) gene was initially identified as a fusion partner of the nucleophosmin gene in anaplastic large-cell lymphoma with t(2;5)(p23;q35) translocation, and then described with different genetic abnormalities in a number of tumors. Although ALK is known to be involved in the pathogenesis of neuroblastoma through activating mutations or gene amplification, its role in the pathogenesis of other pediatric cancers is still elusive. In addition to neuroblastoma, the high-grade amplification of ALK has been described in a subset of rhabdomyosarcoma cases. Read More

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http://dx.doi.org/10.1111/cas.13333DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5623752PMC
October 2017
36 Reads

Massive Embryonal Rhabdomyosarcoma of the Hand in an Infant With Metastasis at Birth: Management Dilemma.

Hand (N Y) 2017 09 4;12(5):NP109-NP112. Epub 2017 Jan 4.

1 Manipal University, India.

Background: Rhabdomyosarcomas are malignant tumors arising from striated muscle but can be often confused with primitive neuroectodermal tumors and Ewing sarcoma. They are often classified based on age of presentation and histological features. Three major types of rhabdomyosarcomas are embryonal, alveolar, and pleomorphic with characteristic presentations. Read More

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http://dx.doi.org/10.1177/1558944716685827DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5684939PMC
September 2017
10 Reads

PHOX2B reliably distinguishes neuroblastoma among small round blue cell tumours.

Histopathology 2017 Nov 6;71(5):786-794. Epub 2017 Sep 6.

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

Aims: Neuroblastoma shows considerable histological overlap with other small round blue cell tumours. PHOX2B, a transcription factor that is essential for autonomic nervous system development, has been reported as an immunohistochemical marker for neuroblastoma. The aim of this study was to validate the specificity and diagnostic utility of PHOX2B for peripheral neuroblastic tumours. Read More

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http://dx.doi.org/10.1111/his.13288DOI Listing
November 2017
16 Reads

Systemic Therapy Outcomes in Adult Patients with Ewing Sarcoma Family of Tumors.

Case Rep Oncol 2017 May-Aug;10(2):462-472. Epub 2017 May 23.

Ottawa Hospital Research Institute, The Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada.

Background: The Ewing sarcoma family of tumors (ESFT) is a rare but curable bone neoplastic entity. The current standard of care involves chemotherapy and local disease control with surgery or radiation regardless of the extent of disease at presentation. Data that document the effectiveness of the current approach in the adult patient population are limited. Read More

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http://dx.doi.org/10.1159/000475806DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5471759PMC
May 2017
18 Reads