1,700 results match your criteria Ewing Sarcoma Imaging


Bone marrow biopsy in the initial staging of Ewing sarcoma: Experience from a single institution.

Pediatr Blood Cancer 2019 Feb 5:e27653. Epub 2019 Feb 5.

Chemotherapy Section, IRCCS-Rizzoli Orthopaedic Institute, Bologna, Italy.

Background: Ewing sarcoma (ES) is the second most common bone tumor in adolescents and children. Staging workup for ES includes imaging and bone marrow biopsy (BMB). The effective role of BMB is now under discussion. Read More

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http://dx.doi.org/10.1002/pbc.27653DOI Listing
February 2019
2.562 Impact Factor

Trabectedin Inhibits EWS-FLI1 and Evicts SWI/SNF from Chromatin in a Schedule Dependent Manner.

Clin Cancer Res 2019 Feb 5. Epub 2019 Feb 5.

Center for Cancer and Cell Biology, Van Andel Research Institute

Purpose: The successful clinical translation of compounds that target specific oncogenic transcription factors will require an understanding of the mechanism of target suppression to optimize the dose and schedule of administration. We have previously shown trabectedin reverses the gene signature of the EWS-FLI1 transcription factor. In this report, we establish the mechanism of suppression and use it to justify the re-evaluation of this drug in the clinic in Ewing sarcoma patients. Read More

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http://dx.doi.org/10.1158/1078-0432.CCR-18-3511DOI Listing
February 2019
1 Read

Ewing's Sarcoma and Primary Osseous Lymphoma: Spectrum of Imaging Appearances.

Semin Musculoskelet Radiol 2019 Feb 30;23(1):36-57. Epub 2019 Jan 30.

Department of Radiology, AZ Sint-Maarten Mechelen, University Hospital Antwerp, Ghent University, Mechelen, Belgium.

Ewing's sarcoma (ES) is a rare, highly malignant anaplastic stem cell tumor. Histologically, the tumor consists of uniform densely packed small monomorphic cells with round nuclei. The typical appearance at hematoxylin and eosin (H&E) staining is small blue round cells without any matrix formation. Read More

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http://dx.doi.org/10.1055/s-0038-1676125DOI Listing
February 2019
3 Reads

Isolated delayed metastasis to the talus from Ewing's sarcoma.

J Radiol Case Rep 2018 Aug 31;12(8):17-24. Epub 2018 Aug 31.

Department Of Radiology, American University Of Beirut Medical Center, Beirut, Lebanon.

Bone metastasis to the hands and feet, known as acrometastasis, is a very rare finding and tends to be associated with extensive metastasis. We herein report the case of a 14-year-old girl known to have a history of successfully treated Ewing's sarcoma arising from the ribs, who presented with a pathologically proven isolated metastatic lesion to the talus 7 years after achieving clinical and radiologic remission. We describe the imaging findings on MRI, CT scan and PET-CT. Read More

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http://dx.doi.org/10.3941/jrcr.v12i8.3164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312123PMC
August 2018
5 Reads

Primary Intra-abdominal Ewing's Sarcoma in Adults: A Multimodality Imaging Spectrum.

Curr Probl Diagn Radiol 2019 Jan 2. Epub 2019 Jan 2.

Department of Radiology, UW Medicine, Seattle, WA. Electronic address:

Ewing sarcoma (ES) and peripheral primitive neuroectodermal tumor are part of a spectrum of neoplastic diseases known as the ES family of tumors, which also includes extraosseous ES, peripheral primitive neuroectodermal tumor, malignant small-cell tumor of the thoracopulmonary region (Askin's tumor), and atypical ES. Although imaging features of these tumors have been previously described, extensive discussion about intra-abdominal manifestations is scarce in the literature. We present an imaging spectrum of these tumors in the abdomen and pelvis with particular attention to multimodality approach for staging and restaging. Read More

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http://dx.doi.org/10.1067/j.cpradiol.2018.12.009DOI Listing
January 2019
1 Read

Primary Ewing sarcoma of the squamous temporal bone with intracranial and extracranial extension: A rare cause of sudden sensorineural hearing loss.

Head Neck 2018 Dec 24. Epub 2018 Dec 24.

Department of Pediatrics and Biomedical Research Institute, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea.

Background: Primary Ewing sarcoma of the cranial bone is rare, accounting for only 1% of all Ewing sarcomas. Primary Ewing sarcoma arising in the squamous temporal bone is particularly rare.

Methods: A 16-year-old male was seen with signs of sudden sensorineural hearing loss (SSNHL). Read More

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http://dx.doi.org/10.1002/hed.25449DOI Listing
December 2018

Intra-neural Ewing's sarcoma of the fibular nerve - Case report, radiological findings and review of literature.

World Neurosurg 2018 Dec 19. Epub 2018 Dec 19.

Neurosurgery Unit, Department of Neurosciences, University of Turin, Turin, Italy.

Intra-neural Ewing's Sarcoma was first described in 1918 by Stout in a tumour of the ulnar nerve. These tumours are comprised in the category of Ewing's Sarcoma Family of Tumours (ESFT), together with Ewing's Sarcoma of Bone (ESB), Extra-osseous Ewing's Sarcoma (EES) and Primitive Neuroectodermal Tumour (PNET). ES typically occurs in the second decade of life; only 20% of cases affects elder people. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.12.043DOI Listing
December 2018
6 Reads

Atypical localization of intraosseous angioleiomyoma in the rib of a pediatric patient: a case report.

BMC Med Imaging 2018 Dec 19;18(1):54. Epub 2018 Dec 19.

Institute of Pathology, School of Medicine, University of Belgrade, Dr Subotica 1, 11000, Belgrade, Republic of Serbia.

Background: This is the first reported case of a primary intraosseous angioleiomyoma and the second case of a primary leiomyoma of the rib, irrespective of age. Angioleiomyomas mostly occur in patients of advanced age, in any part of the body, particularly the lower extremities and present as painful, slow-growing nodules in the dermis, subcutaneous fat or deep fascia. Other localizations, especially bone, are considered extremely rare, as well as their occurrence in paediatric patients. Read More

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http://dx.doi.org/10.1186/s12880-018-0297-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300016PMC
December 2018
5 Reads

Broad Spectrum Activity of the Checkpoint Kinase 1 Inhibitor Prexasertib as a Single Agent or Chemopotentiator Across a Range of Preclinical Pediatric Tumor Models.

Clin Cancer Res 2018 Dec 18. Epub 2018 Dec 18.

Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana.

Checkpoint kinase 1 (CHK1) inhibitors potentiate the DNA-damaging effects of cytotoxic therapies and/or promote elevated levels of replication stress, leading to tumor cell death. Prexasertib (LY2606368) is a CHK1 small-molecule inhibitor under clinical evaluation in multiple adult and pediatric cancers. In this study, prexasertib was tested in a large panel of preclinical models of pediatric solid malignancies alone or in combination with chemotherapy. Read More

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http://dx.doi.org/10.1158/1078-0432.CCR-18-2728DOI Listing
December 2018
1 Read

Lower Extremity Weakness in an Adolescent Female - A Rare Presentation of Ewing Sarcoma.

Ochsner J 2018 ;18(4):402-405

Department of Internal Medicine, Aurora Health Care, Milwaukee, WI.

Background: Ewing sarcoma, a rare cause of cord compression, is predominantly of osseous origin but can also originate in soft tissues. Soft-tissue manifestations account for <15% of all Ewing sarcoma tumors, and even fewer cases of Ewing sarcoma originating in the epidural space have been documented.

Case Report: A 19-year-old female presented to the emergency department for worsening low-back pain during the previous 6 months and numbness and weakness in her legs during the prior 2 weeks. Read More

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http://dx.doi.org/10.31486/toj.18.0039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292469PMC
January 2018

A Pitfall for Diffusion-weighted MR Imaging When Assessing the Response to Neoadjuvant Chemotherapy in Ewing Sarcoma.

Magn Reson Med Sci 2018 Dec 6. Epub 2018 Dec 6.

Department of Radiology, Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen.

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https://www.jstage.jst.go.jp/article/mrms/advpub/0/advpub_ci
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http://dx.doi.org/10.2463/mrms.ci.2018-0122DOI Listing
December 2018
5 Reads

Effectiveness of 18F-FDG PET/CT in the diagnosis, staging and recurrence monitoring of Ewing sarcoma family of tumors: A meta-analysis of 23 studies.

Medicine (Baltimore) 2018 Nov;97(48):e13457

Department of Orthopaedics, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, China.

Background: To investigate the value of positron emission tomography (PET) and PET/computed tomography (CT) using fluorine-18-fluorodeoxyglucose (F-FDG) in the diagnosis, staging, restaging and recurrence monitoring of Ewing sarcoma family of tumors (ESFTs), a meta-analysis was performed through systematically searching PubMed, Embase, and Cochrane Central library to retrieve articles.

Methods: After screening and diluting out the articles that met inclusion criteria to be used for statistical analysis the pooled evaluation indexes including sensitivity, specificity, and diagnostic odd ratio (DOR) as well as the summary receiver operating characteristic curve (SROC) were calculated involving diagnostic data (true positive, false positive, false negative, and true negative) extracted from original studies.

Results: Screening determined that out of 2007, 23 studies involving a total of 524 patients were deemed viable for inclusion in the meta-analysis. Read More

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http://dx.doi.org/10.1097/MD.0000000000013457DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283220PMC
November 2018
5.723 Impact Factor

Ewing's sarcoma of kidney in a 60-year-old patient with local recurrence: A rare occurrence.

J Cancer Res Ther 2018 Oct-Dec;14(6):1422-1424

Department of Medical Oncology, Gazi University Faculty of Medicine, Ankara, Turkey.

Ewing's family of tumors is aggressive tumors and frequently arises from bone and soft tissue. They might also arise from nonosseous structures such as gastrointestinal tract, adrenal glands, or kidney. Primary renal Ewing's sarcoma (ES)/primitive neuroectodermal tumor is an extremely rare entity which has aggressive clinical course. Read More

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http://dx.doi.org/10.4103/0973-1482.191062DOI Listing
February 2019
1 Read

Early recognition and diagnosis of Ewing sarcoma of the cervical spine.

Radiol Case Rep 2019 Feb 2;14(2):160-163. Epub 2018 Nov 2.

Department of Radiology, SUNY Upstate University Hospital, 750 East Adams Street, Syracuse, NY 13210, USA.

Ewing sarcoma of the cervical spine is a rare diagnosis. Early recognition and treatment of this condition improves survival. Reported is a case of a 20-year-old male patient who presented with increasing neck pain. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S19300433183035
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http://dx.doi.org/10.1016/j.radcr.2018.09.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223226PMC
February 2019
8 Reads

Compressive optic neuropathy secondary to Ewing sarcoma in the paranasal sinus: A case report.

Medicine (Baltimore) 2018 Nov;97(44):e13027

Department of Ophthalmology.

Rationale: Ewing sarcoma localized in the paranasal sinuses, compressing the optic nerve, is very rare, with no prior case reports PATIENT CONCERNS:: A 68-year-old woman presented with decreased visual acuity in her left eye and paresthesia of the left face. Brain magnetic resonance imaging showed heterogeneously enhancing mass in the left paranasal sinuses with adjacent bone destruction, extending to the extraocular muscles and optic nerve of the left orbit. A biopsy of the nasal cavity confirmed Ewing sarcoma. Read More

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http://dx.doi.org/10.1097/MD.0000000000013027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221559PMC
November 2018
5 Reads

Scrotal Peripheral Primitive Neuroectodermal Tumor.

Curr Urol 2018 Oct 30;12(1):50-53. Epub 2018 Jun 30.

Radiology Department, Hospital Policlínico La Rosaleda C/Santiago León de Caracas, Santiago de Compostela, Spain.

The peripheral primitive neuroectodermal tumor (pPNET) is a rare malignant tumor originating from neuroectoderm that usually occurs in children or adolescent and is frequently located in the extremities, chest cavity, pelvic cavity and chest wall. We present a rare case of an 84-year-old man with a history of pPNET in the scrotal sac, to our knowledge not previously published in the literature. The presence of a large irreducible mass in the inguinal sac forced to exclude a tumor. Read More

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https://www.karger.com/Article/FullText/447231
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http://dx.doi.org/10.1159/000447231DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198772PMC
October 2018
1 Read

The usefulness of wide excision assisted by a computer navigation system and reconstruction using a frozen bone autograft for malignant acetabular bone tumors: a report of two cases.

BMC Cancer 2018 Oct 24;18(1):1036. Epub 2018 Oct 24.

Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kanazawa University, 13-1 Takara-machi, Kanazawa, 920-8641, Japan.

Background: Difficult resection of tumors from regions with complex local anatomy, such as the pelvis and sacrum, is likely to result in inadequate surgical margins (intralesional or marginal); this is because three-dimensional osteotomy is difficult particularly around the acetabulum. Additionally, removal of the joint makes reconstruction very difficult; thus, retention of good function also becomes difficult. In musculoskeletal oncology, computer navigation systems are still not widely used to prevent tumor-positive margins. Read More

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http://dx.doi.org/10.1186/s12885-018-4971-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201638PMC
October 2018
2 Reads

Ewing Sarcoma in an Infant Metacarpal.

J Hand Surg Am 2018 Oct 17. Epub 2018 Oct 17.

Department of Orthopedic Surgery and Rehabilitation, University of Oklahoma Health Sciences Center, Oklahoma City, OK. Electronic address:

We describe a case of Ewing sarcoma in the metacarpal of a 5-month-old male. After pain, erythema, and swelling of the hand failed to resolve with antibiotics, radiographs and magnetic resonance imaging raised suspicion for a neoplastic condition. Open biopsy confirmed the diagnosis of Ewing sarcoma and treatment with chemotherapy and surgical resection was initiated. Read More

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http://dx.doi.org/10.1016/j.jhsa.2018.09.001DOI Listing
October 2018

Establishment of a novel patient-derived Ewing's sarcoma cell line, NCC-ES1-C1.

In Vitro Cell Dev Biol Anim 2018 Dec 15;54(10):770-778. Epub 2018 Oct 15.

Department of Innovative Seeds Evaluation, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.

Ewing's sarcoma is an aggressive mesenchymal tumor characterized by the presence of a unique EWSR1-FLI1 translocation. Ewing's sarcoma primarily occurs in the bone and soft tissues. Cell lines enable researchers to investigate the molecular backgrounds of disease and the significance of genetic alterations in relevant cellular contexts. Read More

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http://dx.doi.org/10.1007/s11626-018-0302-2DOI Listing
December 2018
10 Reads

Ewing's Sarcoma/Peripheral Primitive Neuroectodermal Tumors in Bronchus.

Am J Med Sci 2019 Jan 22;357(1):75-80. Epub 2018 Aug 22.

Department of Medical imaging, The Second Hospital of Hebei Medical University, Shijiazhuang, China. Electronic address:

Ewing sarcoma/peripheral primitive neuroectodermal tumors (ES/pPNET), a member of the Ewing sarcoma family of tumors, is a malignant soft tissue tumor with small undifferentiated neuroectodermal cells. Primary trachea-bronchial ES/pPNET is very rare. The most common pulmonary ES is due to a metastasis. Read More

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http://dx.doi.org/10.1016/j.amjms.2018.08.009DOI Listing
January 2019
8 Reads

An Uncommon Presentation of a Primary Bone Tumor: Anti-AMPA (Anti-α-Amino-3-Hydroxy-5-Methyl-4-Isoxazolepropionic acid) Receptor Limbic/Paraneoplastic Encephalitis as a Presenting Feature of Ewing Sarcoma.

J Pediatr Hematol Oncol 2018 Oct;40(7):555-557

Department of Diagnostic Imaging, Monash Health.

Anti-AMPA (anti-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptor limbic encephalitis is a rare autoimmune syndrome. It can be associated with an underlying malignancy, such as lung, breast, or thymus. We are reporting a case of a 19-year-old patient who presented with a 2-week history of confusion and short-term memory loss. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001304DOI Listing
October 2018
1 Read

Posterior Reversible Encephalopathy Syndrome in Pediatric Cancer: Clinical and Radiologic Findings.

J Glob Oncol 2018 Sep 4(4):1-8. Epub 2017 Dec 4.

All authors: Shaukat Khanum Cancer Hospital and Research Center, Lahore, Pakistan.

Purpose: Posterior reversible encephalopathy syndrome (PRES) is associated with a range of medical conditions and medications. In this retrospective analysis, we present 19 pediatric patients with PRES who had undergone chemotherapy.

Methods: We identified four female and 15 male patients diagnosed with PRES on the basis of clinical and radiologic features. Read More

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http://dx.doi.org/10.1200/JGO.17.00089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181184PMC
September 2018
3 Reads

Applications of PET/CT and PET/MR Imaging in Primary Bone Malignancies.

PET Clin 2018 Oct 17;13(4):623-634. Epub 2018 Aug 17.

Division of Nuclear Medicine, Department of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90007, USA.

Primary bone malignancies are characterized with anatomic imaging. However, in recent years, there has been an increased interest in PET/computed tomography scanning and PET/MRI with fludeoxyglucose F 18 for evaluating and staging musculoskeletal neoplasms. These hybrid imaging modalities have shown promise largely owing to their high sensitivity, ability to perform more thorough staging, and ability to monitor treatment response. Read More

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http://dx.doi.org/10.1016/j.cpet.2018.05.012DOI Listing
October 2018
14 Reads

Introducing fluorescence guided surgery into orthopedic oncology: A systematic review of candidate protein targets for Ewing sarcoma.

J Surg Oncol 2018 Nov 13;118(6):906-914. Epub 2018 Sep 13.

Department of Surgery, Leiden University Medical Center, The Netherlands.

Ewing sarcoma (ES), an aggressive bone and soft-tissue tumor, is treated with chemotherapy, radiotherapy, and surgery. Intra-operative distinction between healthy and tumorous tissue is of paramount importance but challenging, especially after chemotherapy and at complex anatomical locations. Near infrared (NIR) fluorescence-guided surgery (FGS) is able to facilitate the determination of tumor boundaries intra-operatively, improving complete resection and therefore survival. Read More

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http://dx.doi.org/10.1002/jso.25224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220824PMC
November 2018

Imaging features of Ewing's sarcoma: Special reference to uncommon features and rare sites of presentation.

J Cancer Res Ther 2018 Jul-Sep;14(5):1014-1022

Department of Radiology, Nizam's Institute of Medical Sciences, Hyderabad, Telangana, India.

Context: Ewing's sarcoma (EWS) commonly involves long bones with a permeative pattern of bone destruction and aggressive interrupted periosteal new bone formation. However, radiological features show wide variation and some presentations are uncommon, leading to diagnostic confusion. This study is aimed at studying the imaging features of proven EWS and highlight the uncommon features and rare sites of presentation. Read More

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http://dx.doi.org/10.4103/jcrt.JCRT_1350_16DOI Listing
November 2018
1 Read

Extraosseous Ewing sarcoma arising in a chronically lymphedematous limb.

J Vasc Surg Cases Innov Tech 2018 Sep 17;4(3):210-215. Epub 2018 Aug 17.

Department of Anatomical Pathology, Royal Hobart Hospital, Tasmania, Australia.

Ewing sarcoma is a highly aggressive small round cell malignant neoplasm of bone and soft tissue that typically is manifested in children and young adults. It is most commonly a primary bone tumor; however, extraosseous cases have been increasingly reported. We report a case of metastatic extraosseous Ewing sarcoma with the primary lesion occurring within a limb affected by primary lymphedema. Read More

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http://dx.doi.org/10.1016/j.jvscit.2018.04.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6105752PMC
September 2018
1 Read

Analysis of bone and soft-tissue sarcomas registered during the year 2012 at Tata Memorial Hospital, Mumbai, with clinical outcomes.

Indian J Cancer 2018 Jan-Mar;55(1):37-44

Department of Surgical Pathology, Bone and Soft Tissues, Disease Management Group (DMG), Tata Memorial Hospital, Mumbai, Maharashtra, India.

Introduction: Primary bone and soft tissue sarcomas are rare, but diagnostically and therapeutically challenging group of tumors, requiring multidisciplinary management. There are limited documented studies from multidisciplinary teams , in the form of comprehensive analysis of these tumors, from our country. This study is an analysis of cases of osteosarcomas, Ewing sarcomas (ESs), chondrosarcomas (CSs), and soft-tissue sarcomas (STSs), registered at our institution during 2012. Read More

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http://dx.doi.org/10.4103/ijc.IJC_481_17DOI Listing
November 2018
8 Reads

Diagnostic Immunohistochemistry for Soft Tissue and Bone Tumors: An Update.

Adv Anat Pathol 2018 Nov;25(6):400-412

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

Although some soft tissue and bone tumors can be identified based on histologic features alone, immunohistochemistry plays a critical diagnostic role for most mesenchymal tumor types. The discovery of recurrent genomic alterations in many benign and malignant mesenchymal neoplasms has added important biologic insights and expanded the spectrum of some diagnostic subgroups. Some tumors are defined by unique genomic alterations, whereas others share abnormalities that are not tumor-specific and can be observed in a sometimes broad range of biologically unrelated neoplasms. Read More

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http://dx.doi.org/10.1097/PAP.0000000000000204DOI Listing
November 2018
16 Reads

Abemaciclib Is Active in Preclinical Models of Ewing Sarcoma via Multipronged Regulation of Cell Cycle, DNA Methylation, and Interferon Pathway Signaling.

Clin Cancer Res 2018 Dec 21;24(23):6028-6039. Epub 2018 Aug 21.

Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana.

Purpose: Ewing sarcoma (ES) is a rare and highly malignant cancer that occurs in the bone and surrounding tissue of children and adolescents. The fusion transcription factor that drives ES pathobiology was previously demonstrated to modulate cyclin D1 expression. In this study, we evaluated abemaciclib, a small-molecule CDK4 and CDK6 (CDK4 and 6) inhibitor currently under clinical investigation in pediatric solid tumors, in preclinical models of ES. Read More

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http://clincancerres.aacrjournals.org/lookup/doi/10.1158/107
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http://dx.doi.org/10.1158/1078-0432.CCR-18-1256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279561PMC
December 2018
18 Reads

Sorafenib in patients with progressed and refractory bone tumors.

Med Oncol 2018 Aug 16;35(10):126. Epub 2018 Aug 16.

Department of Oncology and Surgical Oncology for Children and Youth, Institute of Mother and Child, 01-211 Warszawa, ul. Kasprzaka 17a, Warsaw, Poland.

Patients with metastatic, progressive, or recurrent bone tumors have a dismal outcome. Sorafenib has been proposed as an effective salvage regimen for some malignancies. Thus, we sought to evaluate this approach for young patients with relapsed or refractory bone tumors. Read More

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http://dx.doi.org/10.1007/s12032-018-1180-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097021PMC
August 2018
7 Reads

Retrospective audit of 957 consecutive F-FDG PET-CT scans compared to CT and MRI in 493 patients with different histological subtypes of bone and soft tissue sarcoma.

Clin Sarcoma Res 2018 9;8. Epub 2018 Apr 9.

1Oxford Sarcoma Service (OxSarc), Oxford University Hospitals Foundation Trust, Oxford, OX3 7LE UK.

Background: The use of F-FDG PET-CT (PET-CT) is widespread in many cancer types compared to sarcoma. We report a large retrospective audit of PET-CT in bone and soft tissue sarcoma with varied grade in a single multi-disciplinary centre. We also sought to answer three questions. Read More

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http://dx.doi.org/10.1186/s13569-018-0095-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086048PMC
April 2018
2 Reads

Staging and following common pediatric malignancies: MRI versus CT versus functional imaging.

Authors:
Stephan D Voss

Pediatr Radiol 2018 08 4;48(9):1324-1336. Epub 2018 Aug 4.

Department of Radiology, Boston Children's Hospital, Harvard Medical School, 300 Longwood Ave., Boston, MA, 02115, USA.

Most pediatric malignancies require some form of cross-sectional imaging, either for staging or response assessment. The majority of these are solid tumors and this review addresses the role of MRI, as well as other cross-sectional and functional imaging techniques, for evaluating the most common pediatric solid tumors. The primary emphasis is on neuroblastoma, hepatoblastoma and Wilms tumor, three of the most common non-central-nervous-system (CNS) pediatric solid tumors encountered in young children. Read More

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http://dx.doi.org/10.1007/s00247-018-4162-4DOI Listing
August 2018
4 Reads

Ewing Sarcoma of the Femur.

J Orthop Sports Phys Ther 2018 Jul;48(7):594

A 26-year-old active woman with knee pain was seen by her primary care physician and diagnosed with patellofemoral pain (PFP). Radiographs of the knee were interpreted as noncontributory. Her knee symptoms continued, and 8 weeks later she was referred to a physiatrist, who confirmed the PFP diagnosis and referred her to physical therapy. Read More

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http://dx.doi.org/10.2519/jospt.2018.7835DOI Listing
July 2018
16 Reads

Myoepithelioma occurring in the posterior mediastinum harboring EWSR1 rearrangement: a case report.

Jpn J Clin Oncol 2018 Sep;48(9):851-854

Department of General Thoracic, Breast and Endocrinological Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.

Myoepithelioma is a rare neoplasm usually occurring in the salivary glands or the mammary glands but also, more rarely, in the thoracic cavity. The diagnosis of myoepithelioma is based on the presence of histological and immunohistochemical characteristics of myoepithelioma, but in unusual locations, the diagnosis is challenging. For such cases, cytogenetic approaches have been developed as helpful tools for the diagnosis. Read More

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http://dx.doi.org/10.1093/jjco/hyy100DOI Listing
September 2018

Reconstructing diaphyseal tumors using radiated (50 Gy) autogenous tumor bone graft.

J Surg Oncol 2018 Jul 27;118(1):138-143. Epub 2018 Jun 27.

Department of Radiation Oncology, Tata Memorial Hospital, HBNI, Mumbai, India.

Aims: Establish oncologic safety using 50 Gy to sterilize tumor bearing bone before reimplantation in primary diaphyseal high grade extremity tumors, determine extracorporeal radiotherapy (ECRT) graft survival, and analyze factors that affect union at osteotomy sites.

Materials And Methods: Seventy non metastatic patients underwent reconstruction with intercalary ECRT grafts sterilized with 50 Gy. Diagnosis included osteosarcoma (38) and Ewing's sarcoma (32). Read More

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http://doi.wiley.com/10.1002/jso.25092
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http://dx.doi.org/10.1002/jso.25092DOI Listing
July 2018
16 Reads

KDM3A is not associated with metastasis and prognosis of breast cancer.

Oncol Lett 2018 Jun 25;15(6):9751-9756. Epub 2018 Apr 25.

The Imaging Center, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang Uyghur Autonomous Region 830054, P.R. China.

Lysine demethylase 3A (KDM3A), also known as JMJD1A, has been associated with metastasis and poor prognosis in several cancer types, including renal cell carcinoma, prostate cancer and Ewing sarcoma. However, little is known regarding the clinicopathological significance of KDM3A expression in breast cancer (BCa). To investigate the clinical relevance of KDM3A expression in the setting of BCa, immunohistochemistry was performed on a tissue microarray consisting of 150 commercially available BCa samples. Read More

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http://dx.doi.org/10.3892/ol.2018.8578DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6004682PMC
June 2018
1 Read
0.990 Impact Factor

Peripheral primitive neuroendocrine tumor of the chest wall-A case report with pathological correlation.

Radiol Case Rep 2018 Apr 5;13(2):392-396. Epub 2018 Feb 5.

Tufts Medical Center, 800 Washington St, Boston, MA 02111, USA.

Primitive neuroectodermal tumor is a high-grade malignant tumor originating from the neural crest and neuroectoderm, which can be subdivided into central and peripheral categories. Peripheral primitive neuroectodermal tumor is thought to be identical to Ewing's sarcoma, and falls under a broader category of Ewing's sarcoma family of tumors. Very rarely, it may present without osseous involvement, known as extraosseous Ewing's sarcoma. Read More

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http://dx.doi.org/10.1016/j.radcr.2018.01.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6000041PMC
April 2018
6 Reads

Metachronous renal Ewing sarcoma/primitive neuroectodermal tumour in a survivor of Burkitt lymphoma.

BMJ Case Rep 2018 Jun 11;2018. Epub 2018 Jun 11.

Department of Pathology and Laboratory Medicine, Aga Khan University, Karachi, Pakistan.

We present a case of a 14-year-old girl who was diagnosed with Burkitt lymphoma in 2014. She was managed with chemotherapy and remained in remission for 3 years. On her surveillance imaging in 2017, a left-sided renal neoplastic mass was incidentally discovered. Read More

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http://dx.doi.org/10.1136/bcr-2017-224071DOI Listing
June 2018
8 Reads

Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor in the Adrenal Gland of a Child.

Iran J Kidney Dis 2018 05;12(3):190-192

Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Ewing sarcoma/peripheral primitive neuroectodermal tumor (ES/PNET) typically occurs in long or flat bones, soft tissues, or less often, solid organs. Ewing sarcoma/peripheral primitive neuroectodermal tumor arising from the adrenal gland is extremely rare, especially in children, and only limited cases are reported previously. Herein, we review a case of a 22-month-old girl who presented to our department with abdominal pain, bulging of the left flank, and a nonfunctioning adrenal lesion which was found to be an adrenal ES/PNET. Read More

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May 2018
5 Reads

Primary Spinal Intradural Extraosseous Ewing Sarcoma in a Pediatric Patient: Case Report and Review of the Literature.

Pediatr Neurosurg 2018 25;53(4):222-228. Epub 2018 May 25.

Pediatric Oncology and Hematology, Indiana University Health, Indianapolis, Indiana, USA.

Ewing sarcoma (ES) is an aggressive, primary bone malignancy with occasional soft tissue extension. Purely extra-osseous ES is rare. A primary intraspinal, intradural ES without bone involvement is exceedingly rare. Read More

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http://dx.doi.org/10.1159/000488767DOI Listing
September 2018
1 Read

A probable primary malignant bone tumor in a pre-Columbian human humerus from Cerro Brujo, Bocas del Toro, Panamá.

Int J Paleopathol 2018 06 26;21:138-146. Epub 2017 May 26.

Smithsonian Tropical Research Institute, Ancón, Panamá, Panama.

We present a rare case of primary bone cancer principally affecting the right humerus of a skeleton from the pre-Columbian site of Cerro Brujo (1265-1380 CE) in Bocas del Toro, on the Caribbean coast of Panamá, excavated in the early 1970s. The humerus contains a dense, calcified sclerotic mass with associated lytic lesions localized around the midshaft of the diaphysis. Evidence of systemic inflammation and anemia, likely caused by the cancer, are visible in the form of severe porotic hyperostosis of the cranial vault and bilateral periosteal reactions in the tibiae. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18799817163017
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http://dx.doi.org/10.1016/j.ijpp.2017.05.005DOI Listing
June 2018
1 Read

Surveillance MRI for the detection of locally recurrent Ewing sarcoma seems futile.

Skeletal Radiol 2018 May 11. Epub 2018 May 11.

Department of Radiology, Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Hanzeplein 1, PO Box 30.001, 9700 RB, Groningen, The Netherlands.

Purpose: To determine the frequency of locally recurrent Ewing sarcoma on surveillance MRI and the outcome of these patients.

Materials And Methods: This retrospective single-center study included all patients with newly diagnosed Ewing sarcoma who underwent surveillance MRI of the primary tumor location after primary treatment between 1997 and 2016.

Results: Thirty-two patients underwent a total of 176 local surveillance MRI scans, yielding an average of 5. Read More

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http://link.springer.com/10.1007/s00256-018-2966-9
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http://dx.doi.org/10.1007/s00256-018-2966-9DOI Listing
May 2018
9 Reads

FDG-PET CT in the evaluation of primary and secondary pancreatic malignancies.

Pediatr Blood Cancer 2018 Oct 11;65(10):e27115. Epub 2018 May 11.

Department of Diagnostic Imaging, St. Jude Children's Research Hospital, Memphis, Tennessee.

Purpose: Primary pancreatic carcinoma and pancreatic metastases are rare in the pediatric population. Pancreatoblastoma is the most common pancreatic malignant tumor in young children and solid-pseudopapillary tumor in teenagers. Pancreatic adenocarcinoma is extremely rare under the age of 40 and is usually associated with underlying genetic abnormalities. Read More

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http://dx.doi.org/10.1002/pbc.27115DOI Listing
October 2018
2 Reads

Diagnostic value of MRI signs in differentiating Ewing sarcoma from osteomyelitis.

Acta Radiol 2018 Jan 1:284185118774953. Epub 2018 Jan 1.

1 Department of Radiology, Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Background The value of magnetic resonance imaging (MRI) signs in differentiating Ewing sarcoma from osteomyelitis has not be thoroughly investigated. Purpose To investigate the value of various MRI signs in differentiating Ewing sarcoma from osteomyelitis. Material and Methods Forty-one patients who underwent MRI because of a bone lesion of unknown nature with a differential diagnosis that included both Ewing sarcoma and osteomyelitis were included. Read More

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http://dx.doi.org/10.1177/0284185118774953DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328997PMC
January 2018
6 Reads

Primary Intracranial pPNET/Ewing Sarcoma: Diagnosis, Management, and Prognostic Factors Dilemma-A Systematic Review of the Literature.

World Neurosurg 2018 Jul 3;115:346-356. Epub 2018 May 3.

Department of Neurosurgery, Mohamed V Military Hospital, Rabat, Morocco.

Background: Ewing sarcoma (ES) is a malignant bone tumor that is most commonly observed in the long bones, the pelvis, and the chest. Primary intracranial localization is extremely rare.

Objective: In the aim of identifying the prognostic factors of this rare localization, we conducted a systematic review of the literature for patients with primary intracranial peripheral primitive neuroectodermal tumor/ES. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.04.164DOI Listing
July 2018
9 Reads
2.420 Impact Factor

Limb saving surgery for Ewing's sarcoma of the distal tibia: a case report.

BMC Cancer 2018 05 2;18(1):503. Epub 2018 May 2.

Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto, Kyoto, 602-8566, Japan.

Background: Ewing's sarcoma is a primary malignant tumor of bone occurring mostly in childhood. Few effective reconstruction techniques are available after wide resection of Ewing's sarcoma at the distal end of the tibia. Reconstruction after wide resection is especially difficult in children, as it is necessary to consider the growth and activity of the lower limbs. Read More

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http://dx.doi.org/10.1186/s12885-018-4372-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5930845PMC
May 2018
14 Reads

Primary Ewing Sarcoma of Frontotemporal Bone in Geriatric Patient.

World Neurosurg 2018 Jul 30;115:278-281. Epub 2018 Apr 30.

Department of Neurosurgery, T. C. Ministry of Health Okmeydani Education and Research Hospital, Istanbul, Turkey.

Background: Ewing sarcoma is a rare primary malignant bone tumor, which mainly affects children and adolescents. Calvarial bone involvement and its appearance in elderly patients are extremely rare.

Case Description: We presented a 68-year-old female patient with headache and right frontotemporal swelling. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.04.158DOI Listing
July 2018
16 Reads

Extra-Osseous Ewing Sarcoma of Sciatic Nerve Masquerading as Benign Nerve Sheath Tumor and Presented as Lumbar Radiculopathy: Case Report and Review of Literature.

World Neurosurg 2018 Jul 16;115:89-93. Epub 2018 Apr 16.

Department of Neurosurgery, Nanoori Hospital, Seoul, South Korea.

Background: Extraosseous Ewing sarcoma (EES) arising from peripheral nerves is extremely rare with only 11 cases mentioned in the literature. It poses a diagnostic challenge to the clinicians due to its nonspecific presentation and rare occurrence.

Case Description: A 56-year-old woman came with a history of low back pain and intractable right leg pain. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.04.045DOI Listing
July 2018
8 Reads

Review with novel markers facilitates precise categorization of 41 cases of diagnostically challenging, "undifferentiated small round cell tumors". A clinicopathologic, immunophenotypic and molecular analysis.

Ann Diagn Pathol 2018 Jun 29;34:1-12. Epub 2017 Nov 29.

Pathology Department, University of Valencia, Valencia, Spain.

Background: Despite extensive immunohistochemical (IHC) and molecular studies combined with morphologic findings, a group of round/ovoid cell tumors histologically similar to Ewing sarcomas (ES) but lacking EWSR1-rearrangements may remain unclassifiable.

Design: We retrospectively analyzed 41 Ewing-like tumors (formalin-fixed, paraffin-embedded) previously determined as negative or non-informative for EWSR1-rearrangements by FISH and/or RT-PCR. A new histopathology revision and additional IHC and molecular analyses were carried out in order to investigate whether additional IHC and/or molecular testing in combination with the morphological findings may help in reaching a definitive diagnosis. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2017.11.011DOI Listing
June 2018
8 Reads

Histologic Features and Prognosis of Spinal Intradural Extramedullary Ewing Sarcoma: Case Report, Literature Review, and Analysis of Prognosis.

World Neurosurg 2018 Jul 11;115:448-452.e2. Epub 2018 Apr 11.

Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota, USA. Electronic address:

Background: Ewing sarcoma is a malignant neoplasm that primarily involves extremity long bones, the pelvis, and soft tissues of children. The intradural extramedullary space is an uncommon location for Ewing sarcoma, and there is therefore a paucity of information regarding the features and natural history of this particular presentation. There is controversy regarding preoperative diagnosis, surgical management, and postoperative care, and there are no accepted standards. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.04.015DOI Listing
July 2018
4 Reads