12,941 results match your criteria Ewing Sarcoma Imaging


Microsurgical reconstruction with vascularized fibula and massive bone allograft for bone tumors.

Eur J Orthop Surg Traumatol 2018 Dec 5. Epub 2018 Dec 5.

Department of Orthopaedic Surgery, IRCCS Istituto Ortopedico Rizzoli, via Pupilli n1, 40136, Bologna, Italy.

Introduction: Combining massive bone allograft and vascularized fibula in intercalary reconstruction following resection of bone tumors represents a complex reconstructive procedure that requires specialists in microvascular surgery as well as orthopedic surgery. The purpose of our study was to examine the outcomes using this surgical technique in patients with bone tumors in terms of oncologic results, complications related to surgery, Musculoskeletal Tumor Society (MSTS) scores and duration of surgery.

Materials And Methods: We analyzed 81 patients with femoral or tibial sarcomas who underwent intercalary resection and microsurgical reconstruction with massive bone allograft and vascularized fibula. Read More

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December 2018

Breaking point: the genesis and impact of structural variation in tumours.

F1000Res 2018 19;7. Epub 2018 Nov 19.

MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, The University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH42XU, UK.

Somatic structural variants undoubtedly play important roles in driving tumourigenesis. This is evident despite the substantial technical challenges that remain in accurately detecting structural variants and their breakpoints in tumours and in spite of our incomplete understanding of the impact of structural variants on cellular function. Developments in these areas of research contribute to the ongoing discovery of structural variation with a clear impact on the evolution of the tumour and on the clinical importance to the patient. Read More

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November 2018

Draft genomes of strains isolated from dried spices bring unique insights into the diversity of plant-associated strains.

Stand Genomic Sci 2018 29;13:35. Epub 2018 Nov 29.

1Center of Food Safety and Applied Nutrition, U. S. Food and Drug Administration, 8301 Muirkirk Road, Laurel, MD 20708 USA.

is a Gram-negative opportunistic pathogen that causes life- threatening infantile infections, such as meningitis, septicemia, and necrotizing enterocolitis, as well as pneumonia, septicemia, and urinary tract and wound infections in adults. Here, we report 26 draft genome sequences of , which were obtained from dried spices from the USA, the Middle East, China, and the Republic of Korea. The average genome size of the genomes was 4393 kb, with an average of 4055 protein coding genes, and an average genome G + C content of 56. Read More

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November 2018
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Cutaneous Ewing Sarcoma and Ewing Sarcoma of the Bone: Distinct Diseases.

Case Rep Oncol 2018 Sep-Dec;11(3):729-734. Epub 2018 Nov 12.

Kaiser Permanente, Los Angeles, California, USA.

Ewing sarcoma is an aggressive mesenchymal malignancy. It is the second most common bone tumor among children and adolescents and less commonly presents as a soft tissue or primary skin lesion. Cutaneous Ewing sarcoma has only been reported in case reports and case series. Read More

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November 2018
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A Pitfall for Diffusion-weighted MR Imaging When Assessing the Response to Neoadjuvant Chemotherapy in Ewing Sarcoma.

Magn Reson Med Sci 2018 Dec 6. Epub 2018 Dec 6.

Department of Radiology, Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen.

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December 2018
1 Read

Comparison of Pesticide Exposure in Honey Bees (Hymenoptera: Apidae) and Bumble Bees (Hymenoptera: Apidae): Implications for Risk Assessments.

Environ Entomol 2018 Dec 3. Epub 2018 Dec 3.

Syngenta, Jealott's Hill International Research Station, Bracknell, Berkshire, United Kingdom.

To date, regulatory pesticide risk assessments have relied on the honey bee (Apis mellifera L.) (Hymenoptera: Apidae) as a surrogate test species for estimating the risk of pesticide exposure to all bee species. However, honey bees and non-Apis bees may differ in their susceptibility and exposure to pesticides. Read More

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December 2018

Myelolytic Treatments Enhance Oncolytic Herpes Virotherapy in Models of Ewing Sarcoma by Modulating the Immune Microenvironment.

Mol Ther Oncolytics 2018 Dec 18;11:62-74. Epub 2018 Oct 18.

Center for Childhood Cancer and Blood Diseases, Nationwide Children's Hospital, The Ohio State University, Columbus, OH 43205, USA.

Ewing sarcoma is a highly aggressive cancer that promotes the infiltration and activation of pro-tumor M2-like macrophages. Oncolytic virotherapy that selectively infects and destroys cancer cells is a promising option for treating Ewing sarcoma. The effect of tumor macrophages on oncolytic virus therapy, however, is variable among solid tumors and is unknown in Ewing sarcoma. Read More

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December 2018

Prosthodontic treatment of a patient with Ewing sarcoma of the left maxillary sinus: A clinical report.

J Prosthet Dent 2018 Nov 30. Epub 2018 Nov 30.

Associate Professor, Section of Oral Oncology and Maxillofacial Prosthodontics, Department of Head and Neck Surgery, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.

This clinical report describes the prosthodontic rehabilitation of a 22-year-old woman with a substantial treatment history of Ewing sarcoma of the left maxillary sinus. The patient was diagnosed with Ewing sarcoma at the age of 7 years and went through chemotherapy, radiation, surgical resection, and free-flap reconstruction, initially without prosthodontic rehabilitation. The patient aged 22 years was referred to the oral oncology clinic at The University of Texas MD Anderson Cancer Center for prosthodontic treatment. Read More

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November 2018

Non-Apis Bee Exposure Workshop: Industry Participants' View.

Environ Entomol 2018 Dec 4. Epub 2018 Dec 4.

Syngenta, Jealott's Hill International Research Station, Bracknell, Berks, United Kingdom.

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December 2018

Congenital Ewing's Sarcoma, a Rare and Difficult Diagnosis: A Case Report.

Eurasian J Med 2018 Oct;50(3):202-203

Department of Gynecology and Obstetrics, Atatürk University School of Medicine, Erzurum, Turkey.

We have interestedly read the article written by Thalia Wong BS in July 2015, which is about Pediatric Blood Cancer, including clinical findings and results of infants <1 year of age with Ewing sarcoma. We report a case with congenital Ewing's sarcoma that easily interfered with rabdomyosarcoma in a pregnant woman. A 32-year-old multigravida with a big neck mass at 35 weeks was referred to our clinic. Read More

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October 2018

Building capacity for advances in tuberculosis research; proceedings of the third RePORT international meeting.

Tuberculosis (Edinb) 2018 Dec 1;113:153-162. Epub 2018 Oct 1.

FHI 360 and Duke University, Durham, NC, USA. Electronic address:

RePORT International is a global network of research sites in India, Brazil, Indonesia, South Africa, China, and the Philippines dedicated to collaborative tuberculosis research in the context of HIV. A standardized research protocol (the Common Protocol) guides the enrollment of participants with active pulmonary tuberculosis and contacts into observational cohorts. The establishment of harmonized clinical data and bio-repositories will allow cutting-edge, large-scale advances in the understanding of tuberculosis, including identification of novel biomarkers for progression to active tuberculosis and relapse after treatment. Read More

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December 2018

Developing a Minimally Structured Mathematical Model of Cancer Treatment with Oncolytic Viruses and Dendritic Cell Injections.

Comput Math Methods Med 2018 30;2018:8760371. Epub 2018 Oct 30.

Department of Mathematics and Computer Science, University of Richmond, Richmond, Virginia, USA.

Mathematical models of biological systems must strike a balance between being sufficiently complex to capture important biological features, while being simple enough that they remain tractable through analysis or simulation. In this work, we rigorously explore how to balance these competing interests when modeling murine melanoma treatment with oncolytic viruses and dendritic cell injections. Previously, we developed a system of six ordinary differential equations containing fourteen parameters that well describes experimental data on the efficacy of these treatments. Read More

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October 2018
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Effectiveness of 18F-FDG PET/CT in the diagnosis, staging and recurrence monitoring of Ewing sarcoma family of tumors: A meta-analysis of 23 studies.

Medicine (Baltimore) 2018 Nov;97(48):e13457

Department of Orthopaedics, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, China.

Background: To investigate the value of positron emission tomography (PET) and PET/computed tomography (CT) using fluorine-18-fluorodeoxyglucose (F-FDG) in the diagnosis, staging, restaging and recurrence monitoring of Ewing sarcoma family of tumors (ESFTs), a meta-analysis was performed through systematically searching PubMed, Embase, and Cochrane Central library to retrieve articles.

Methods: After screening and diluting out the articles that met inclusion criteria to be used for statistical analysis the pooled evaluation indexes including sensitivity, specificity, and diagnostic odd ratio (DOR) as well as the summary receiver operating characteristic curve (SROC) were calculated involving diagnostic data (true positive, false positive, false negative, and true negative) extracted from original studies.

Results: Screening determined that out of 2007, 23 studies involving a total of 524 patients were deemed viable for inclusion in the meta-analysis. Read More

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November 2018

Overcoming the Limitations of γ, and δ-C-H Arylation of Amines through Ligand Development.

J Am Chem Soc 2018 Nov 30. Epub 2018 Nov 30.

L,X-type transient directing groups (TDG) based on a reversible imine linkage have emerged as broadly useful tools for C-H activation of ketones and free amines. However, competitive binding interactions among multiple reaction components (TDG itself, substrate, and substrate-TDG adduct) with the palladium catalyst often lead to the formation of multiple unreactive complexes, rendering ligand development extremely challenging. Herein we report the finding of versatile 2-pyridone ligands that addresses these problems and significantly improves the γ-methylene arylation of alkyl amines, extending the coupling partners to a wide range of medicinally important heteroaryl iodides and even previously unreactive heteroaryl bromides. Read More

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November 2018
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Maternally expressed, paternally imprinted, embryonic non-coding RNA are expressed in osteosarcoma, Ewing sarcoma and spindle cell sarcoma.

Pathology 2018 Nov 26. Epub 2018 Nov 26.

Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich, United Kingdom; Department of Clinical Biochemistry, Norfolk and Norwich University Hospital, Norwich Research Park, Norwich, United Kingdom. Electronic address:

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November 2018

Clinical features and long-term outcome of primary intracranial Ewing sarcoma/peripheral primitive neuroectodermal tumors: 14 cases from a single institution.

World Neurosurg 2018 Nov 26. Epub 2018 Nov 26.

Department of Neurosurgery, Tongji Hospital, Tongji Medical School, Huazhong University of Science and Technology, Wuhan, Hubei 430030, People's Republic of China. Electronic address:

Objective: Primary intracranial Ewing sarcoma (ES)/peripheral primitive neuroectodermal tumors (pPNETs) are extremely rare, and only a few studies have reported more than four cases of this disease. The purpose of this study was to explore the clinical features, treatment, and outcome of primary intracranial ES/pPNETs.

Methods: The clinical data of 14 patients who had been surgically treated from February 2003 to November 2017 and in whom immunohistochemical staining results had confirmed the diagnosis of primary intracranial ES/pPNETs were retrospectively analyzed. Read More

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November 2018

Super-enhancer-associated MEIS1 promotes transcriptional dysregulation in Ewing sarcoma in co-operation with EWS-FLI1.

Nucleic Acids Res 2018 Nov 28. Epub 2018 Nov 28.

Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.

As the second most common malignant bone tumor in children and adolescents, Ewing sarcoma is initiated and exacerbated by a chimeric oncoprotein, most commonly, EWS-FLI1. In this study, we apply epigenomic analysis to characterize the transcription dysregulation in this cancer, focusing on the investigation of super-enhancer and its associated transcriptional regulatory mechanisms. We demonstrate that super-enhancer-associated transcripts are significantly enriched in EWS-FLI1 target genes, contribute to the aberrant transcriptional network of the disease, and mediate the exceptional sensitivity of Ewing sarcoma to transcriptional inhibition. Read More

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November 2018

Ewing's sarcoma of kidney in a 60-year-old patient with local recurrence: A rare occurrence.

J Cancer Res Ther 2018 Oct-Dec;14(6):1422-1424

Department of Medical Oncology, Gazi University Faculty of Medicine, Ankara, Turkey.

Ewing's family of tumors is aggressive tumors and frequently arises from bone and soft tissue. They might also arise from nonosseous structures such as gastrointestinal tract, adrenal glands, or kidney. Primary renal Ewing's sarcoma (ES)/primitive neuroectodermal tumor is an extremely rare entity which has aggressive clinical course. Read More

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November 2018
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Translocation-Related Sarcomas.

Int J Mol Sci 2018 Nov 28;19(12). Epub 2018 Nov 28.

Department of Medical Oncology, Cancer Institute Hospital of the Japanese Foundation for Cancer Research, Tokyo 135-0063, Japan.

Chromosomal translocations are observed in approximately 20% of soft tissue sarcomas (STS). With the advances in pathological examination technology, the identification of translocations has enabled precise diagnoses and classifications of STS, and it has been suggested that the presence of and differences in translocations could be prognostic factors in some translocation-related sarcomas. Most of the translocations in STS were not regarded as targets of molecular therapies until recently. Read More

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November 2018

The genomics of desmoplastic small round cell tumor reveals the deregulation of genes related to DNA damage response, epithelial-mesenchymal transition, and immune response.

Cancer Commun (Lond) 2018 Nov 28;38(1):70. Epub 2018 Nov 28.

Department of Diagnostic Pathology and Laboratory Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, 20133, Milan, Italy.

Background: Desmoplastic small round cell tumor (DSRCT) is a rare, aggressive, and poorly investigated simple sarcoma with a low frequency of genetic deregulation other than an Ewing sarcoma RNA binding protein 1 (EWSR1)-Wilm's tumor suppressor (WT1) translocation. We used whole-exome sequencing to interrogate six consecutive pre-treated DSRCTs whose gene expression was previously investigated.

Methods: DNA libraries were prepared from formalin-fixed, paraffin-embedded archival tissue specimens following the Agilent SureSelectXT2 target enrichment protocol and sequenced on Illumina NextSeq 500. Read More

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November 2018

Some soil-inhabiting mites from Zanzibar (Acari: Laelapidae).

Zootaxa 2018 Nov 5;4514(1):23-40. Epub 2018 Nov 5.

Tyumen State University, Tyumen, Russia..

This paper reports on six species of soil-inhabiting mites of the family Laelapidae from Zanzibar, Tanzania: Gaeolaelaps praesternalis (Willmann), G. zanzibarensis sp. nov. Read More

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November 2018

EWSR1, a multifunctional protein, regulates cellular function and aging via genetic and epigenetic pathways.

Biochim Biophys Acta Mol Basis Dis 2018 Nov 24. Epub 2018 Nov 24.

Boston University Alzheimer's Disease Center and Departments of Neurology, Boston University School of Medicine, Boston, MA 02118, United States of America; Veteran's Affairs Boston Healthcare System, Boston, MA 02130, USA; Centers for Neuromedicine and Neuroscience, Brain Science Institute, Korea Institute of Science and Technology, Seoul 02792, South Korea. Electronic address:

Ewing's sarcoma (EWS) is a bone cancer arising predominantly in young children. EWSR1 (Ewing Sarcoma breakpoint region 1/EWS RNA binding protein 1) gene is ubiquitously expressed in most cell types, indicating it has diverse roles in various cellular processes and organ development. Recently, several studies have shown that missense mutations of EWSR1 genes are known to be associated with central nervous system disorders such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Read More

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November 2018
2 Reads

SfnR2 Regulates Dimethylsulfide-Related Utilization in PAO1.

J Bacteriol 2018 Nov 26. Epub 2018 Nov 26.

Department of Chemistry, State University of New York, College of Environmental Science and Forestry, Syracuse, New York, USA

Dimethylsulfide (DMS) is a volatile sulfur compound produced mainly from the degradation of dimethylsulfoniopropionate (DMSP) in marine environments. DMS undergoes oxidation to form dimethylsulfoxide (DMSO), dimethylsulfone (DMSO) and methanesulfonate (MSA), all of which occur in terrestrial environments and are accessible for consumption by various microorganisms. The purpose of the current study was to determine how the enhancer-binding proteins SfnR1 and SfnR2 contribute to the utilization of DMS and its derivatives in PAO1. Read More

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November 2018
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Efficacy and safety of regorafenib in adult patients with metastatic osteosarcoma: a non-comparative, randomised, double-blind, placebo-controlled, phase 2 study.

Lancet Oncol 2018 Nov 23. Epub 2018 Nov 23.

Medical Oncology Department, Centre Léon Bérard, Lyon, France.

Background: Regorafenib has proven activity in patients with pretreated gastrointestinal stromal tumours and colorectal and hepatocellular carcinoma. We designed REGOBONE to assess the efficacy and safety of regorafenib for patients with progressive metastatic osteosarcoma and other bone sarcomas. This trial comprised four parallel independent cohorts: osteosarcoma, Ewing sarcoma, chondrosarcoma, and chordoma. Read More

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November 2018
2 Reads

Clinical Study of Cardiac Autonomic Dysfunction and QT Dispersion in Newly Diagnosed HIV/AIDS Patients and its Correlation with CD4 Count.

J Assoc Physicians India 2018 May;66(5):66-68

Professor Jawahar Lal Nehru Medical College and Hospital, Ajmer, Rajasthan.

Objective: To evaluate the cardiac autonomic dysfunction and QT dispersion in newly diagnosed HIV/AIDS patients and to correlate the cardiac autonomic dysfunction with CD4 count.

Methods: It was a prospective study conducted on 50 patients (25 HIV positive without AIDS and 25 HIV with AIDS) and 50 healthy controls in the department of General Medicine, JLN Hospital, Ajmer. Autonomic function was assessed by Ewing battery of autonomic function tests and QT dispersion was calculated. Read More

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Prevalence of CD20 cutaneous epitheliotropic T-cell lymphoma in dogs: a retrospective analysis of 24 cases (2011-2018) in the USA.

Vet Dermatol 2018 Nov 25. Epub 2018 Nov 25.

Department of Comparative, Diagnostic, and Population Medicine, College of Veterinary Medicine, University of Florida, PO Box 100123, Gainesville, FL, 32610, USA.

Background: Limited information is known about the baseline frequency of canine CD20 positive ( ) cutaneous epitheliotropic T-cell lymphoma. A single canine case report has been published.

Objectives: To characterize the baseline frequency of CD20 staining in cases of canine cutaneous epitheliotropic T-cell lymphoma; to assess its values as a prognostic indicator. Read More

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November 2018
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Ultrasensitive quantification of tumor mRNAs in extracellular vesicles with an integrated microfluidic digital analysis chip.

Lab Chip 2018 Dec;18(24):3790-3801

Department of Chemistry, University of Kansas, Lawrence, KS, USA.

Extracellular vesicles (EVs) present a promising liquid biopsy for cancer diagnosis. However, it remains a daunting challenge to quantitatively measure molecular contents of EVs including tumor-associated mRNAs. Herein, we report a configurable microwell-patterned microfluidic digital analysis platform combined with a dual-probe hybridization assay for PCR-free, single-molecule detection of specific mRNAs in EVs. Read More

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December 2018
2 Reads

MiR-708-5p is inversely associated with EWS/FLI1 Ewing sarcoma but does not represent a prognostic predictor.

Cancer Genet 2018 Nov 13. Epub 2018 Nov 13.

Department of Biomechanics, Medicine and Rehabilitation of the Locomotor System, Ribeirão Preto School of Medicine, University of São Paulo, Av. Bandeirantes, 3,900, Bairro Monte Alegre, CEP 14040-901 Ribeirão Preto, SP, Brazil. Electronic address:

Background: Overall survival of Ewing sarcoma (EWS) remains poor and less than 30% of patients with metastatic or recurrent disease survive despite current treatments. Thus, there is a constant search for new biomarkers for diagnosis, prognosis and prediction of therapy. Numerous studies have reported the abnormal expression of miR-708-5p in tumors of different origins. Read More

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November 2018
4 Reads

HuC/D expression in small round cell tumors and neuroendocrine tumors: a useful tool for distinguishing neuroblastoma from childhood small round cell tumors.

Hum Pathol 2018 Nov 20. Epub 2018 Nov 20.

Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan. Electronic address:

The RNA-binding protein HuC/D displays a neuron-specific expression and is involved in neuronal differentiation and the maintenance of the nervous system. Here we investigated the diagnostic value of HuC/D in neuroblastomas. We evaluated 85 neuroblastic tumors: 81 neuroblastomas; three ganglioneuroblastomas, intermixed; one ganglioneuroma, maturing, and 101 other tumors consisting of 34 Ewing sarcomas, 14 nephroblastomas, 11 rhabdomyosarcomas, 15 pulmonary small cell carcinomas, 18 pancreatic neuroendocrine tumors, and nine pheochromocytomas. Read More

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November 2018
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Clinical Utility of In Situ Hybridization Assays in Head and Neck Neoplasms.

Head Neck Pathol 2018 Nov 22. Epub 2018 Nov 22.

Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Sydney, Australia.

Head and neck pathology present a unique set of challenges including the morphological diversity of the neoplasms and presentation of metastases of unknown primary origin. The detection of human papillomavirus and Epstein-Barr virus associated with squamous cell carcinoma and newer entities like HPV-related carcinoma with adenoid cystic like features have critical prognostic and management implications. In salivary gland neoplasms, differential diagnoses can be broad and include non-neoplastic conditions as well as benign and malignant neoplasms. Read More

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November 2018
3 Reads

Augmented reality in computer-assisted interventions based on patient-specific 3D printed reference.

Healthc Technol Lett 2018 Oct 14;5(5):162-166. Epub 2018 Sep 14.

Departamento de Bioingeniería e Ingeniería Aeroespacial, Universidad Carlos III de Madrid, Madrid, Spain.

Augmented reality (AR) can be an interesting technology for clinical scenarios as an alternative to conventional surgical navigation. However, the registration between augmented data and real-world spaces is a limiting factor. In this study, the authors propose a method based on desktop three-dimensional (3D) printing to create patient-specific tools containing a visual pattern that enables automatic registration. Read More

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October 2018
4 Reads

Analytical procedure to assess the performance characteristics of a non-spectroscopic infrared optical sensor for discrimination of chemical vapors.

Appl Opt 2018 Oct;57(30):8903-8913

An optical-filter-based sensor that was designed to mimic human color vision was recently developed. This sensor uses three mid-infrared optical filters to discriminate between chemicals with similar, strongly overlapping mid-infrared absorption bands. This non-spectroscopic technique requires no spectral scanning. Read More

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October 2018

Comorbidities, risk, and socioeconomic factors of uninsured cancer survivors.

Medicine (Baltimore) 2018 Nov;97(47):e13121

Department of Family Medicine, University of South Florida, FL.

Cancer patients can be well-connected to resources during treatment but become lost to follow-up and subsequently may receive treatment in free clinics for chronic morbidities. Few studies have examined outcomes for uninsured patients with cancer histories in free clinics, but research examining socioeconomic determinants emphasizes poor cancer outcomes for patients with lower socioeconomic statuses (SES).Demographic data and chronic disease measures were extracted from medical charts of patients treated in 8 free clinics in 2016 in Tampa Bay. Read More

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November 2018
2 Reads

Axonal Stimulations With a Higher Frequency Generate More Randomness in Neuronal Firing Rather Than Increase Firing Rates in Rat Hippocampus.

Front Neurosci 2018 24;12:783. Epub 2018 Oct 24.

Department of Biomedical Engineering, The College of New Jersey, Ewing, NJ, United States.

Deep brain stimulation (DBS) has been used for treating many brain disorders. Clinical applications of DBS commonly require high-frequency stimulations (HFS, ∼100 Hz) of electrical pulses to obtain therapeutic efficacy. It is not clear whether the electrical energy of HFS functions other than generating firing of action potentials in neuronal elements. Read More

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October 2018

Diagnosis of known sarcoma fusions and novel fusion partners by targeted RNA sequencing with identification of a recurrent ACTB-FOSB fusion in pseudomyogenic hemangioendothelioma.

Mod Pathol 2018 Nov 21. Epub 2018 Nov 21.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.

Integration of morphological, immunohistochemical, and molecular methods is often necessary for the precise diagnosis and optimal clinical management of sarcomas. We have validated and implemented a clinical molecular diagnostic assay, MSK- Fusion Solid, for detection of gene fusions in solid tumors, including sarcomas. Starting with RNA extracted from formalin-fixed paraffin-embedded tumor material, this targeted RNA sequencing assay utilizes anchored multiplex PCR to detect oncogenic fusion transcripts involving 62 genes known to be recurrently rearranged in solid tumors including sarcomas without prior knowledge of fusion partners. Read More

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November 2018
4 Reads

Imbalance of tyrosine by modulating TyrA arogenate dehydrogenases impacts growth and development of Arabidopsis thaliana.

Plant J 2018 Nov 20. Epub 2018 Nov 20.

Department of Botany, University of Wisconsin, B214 Birge Hall, 430 Lincoln Drive, Madison, WI, 53706, USA.

L-Tyrosine is an essential aromatic amino acid required for synthesis of proteins and a diverse array of plant natural products; however, little is known how the levels of tyrosine are controlled in planta and linked to overall growth and development. Most plants synthesize tyrosine by TyrA arogenate dehydrogenases, which are strongly feedback inhibited by tyrosine and encoded by TyrA1 and TyrA2 genes in Arabidopsis thaliana. While TyrA enzymes have been extensively characterized at biochemical levels, their in planta functions remain uncertain. Read More

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November 2018
2 Reads

Medially-Stabilized Total Knee Arthroplasty Does Not Alter Knee Laxity and Balance in Cadaveric Knees.

J Orthop Res 2018 Nov 20. Epub 2018 Nov 20.

Department of Mechanical and Aerospace Engineering, The Ohio State University, Columbus, OH, United States.

Instability after total knee arthroplasty (TKA) can lead to suboptimal outcomes and revision surgery. Medially-stabilized implants aim to more closely replicate normal knee motion than other implants following TKA, but no study has investigated knee laxity (motion under applied loads) and balance (i.e. Read More

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November 2018
2 Reads

Competitive repopulation of an empty microglial niche yields functionally distinct subsets of microglia-like cells.

Nat Commun 2018 Nov 19;9(1):4845. Epub 2018 Nov 19.

Applied Immunology and Immunotherapy, Department of Clinical Neuroscience, Karolinska Institutet, Center for Molecular Medicine, Karolinska Hospital Solna, Stockholm, 17176, Sweden.

Circulating monocytes can compete for virtually any tissue macrophage niche and become long-lived replacements that are phenotypically indistinguishable from their embryonic counterparts. As the factors regulating this process are incompletely understood, we studied niche competition in the brain by depleting microglia with >95% efficiency using Cx3cr1R26 mice and monitored long-term repopulation. Here we show that the microglial niche is repopulated within weeks by a combination of local proliferation of CX3CR1F4/80Clec12a microglia and infiltration of CX3CR1F4/80Clec12a macrophages that arise directly from Ly6C monocytes. Read More

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November 2018
4 Reads

Prognostic factors for survival in Ewing sarcoma: A systematic review.

Surg Oncol 2018 Dec 30;27(4):603-610. Epub 2018 Jul 30.

Leiden University Medical Center, Department of Orthopedic Surgery, Albinusdreef 2, 2300, RC, Leiden, The Netherlands.

Development of a prognostic model for survival can assist in stratifying treatment according to the individual patients' risk, leading to risk- and response adaptive treatment strategies which allow for early decision making. The aim of this systematic review is to provide an overview of prognostic factors for overall survival (OS) and event-free survival (EFS) in Ewing sarcoma to be used in the development of prediction models and clinical trial design. A literature search was performed using Pubmed, Embase, Web of Science, Academic search premier and Cochrane databases. Read More

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December 2018
3 Reads

Ewing's Sarcoma of the Head and Neck: Margins are not just for surgeons.

Cancer Med 2018 Nov 17. Epub 2018 Nov 17.

Department of Oncology for Child and Adolescents, Gustave Roussy, Villejuif, France.

Background, Methods: To describe the characteristics, treatments (systemic/local), and outcome (oncological/functional) of French patients with head and neck Ewing's sarcomas (HNES) registered in the Euro-Ewing 99 (EE99) database. Specific patient-level data were reviewed retrospective.

Results: Forty-seven HNES patients in the EE99 database had a median age of 11 years, 89% had bone tumors (skull 55%, mandible 21%, maxilla 11%), 89% had small tumors (<200 mL), and they were rarely metastatic (9%). Read More

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November 2018
2 Reads

Heart rate variability in hyperthyroidism on sub Saharan African patients: a case-control study.

BMC Res Notes 2018 Nov 15;11(1):814. Epub 2018 Nov 15.

National Obesity Center, Yaoundé Central Hospital, Yaoundé, Cameroon.

Objective: We aimed to determine heart rate variability in freshly diagnosed untreated hyperthyroidism patients. We enrolled 10 patients (9 females) and 10 matched controls for sex and age. Each eligible patient underwent five different tests according to Ewing battery tests for cardiac autonomic dysfunction assessment. Read More

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November 2018
5 Reads

WNT6 is an effective marker for osteosarcoma diagnosis and prognosis.

Medicine (Baltimore) 2018 Nov;97(46):e13011

Department of Orthopaedics, Pangang Group General Hospital, Panzhihua, Sichuan, China.

Wingless-Type MMTV Integration Site Family, Member 6 (WNT6) is a member of the Wnt family and its expression is abnormal in different human cancer cell lines. The purpose of this study was to investigate the clinical significance of WNT6 in osteosarcoma.The levels of WNT6 mRNA and protein in tissue and serum were detected through quantitative real-time polymorperase chain reaction (qRT-PCR) and Enzyme Lined Immunosorbent Assay (ELISA), respectively. Read More

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November 2018
5 Reads

Decreased β-Cell Function is Associated with Cardiovascular Autonomic Neuropathy in Chinese Patients Newly Diagnosed with Type 2 Diabetes.

Neurosci Bull 2018 Nov 15. Epub 2018 Nov 15.

Department of Endocrinology and Metabolism, Guangdong Provincial Key Laboratory of Diabetology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510630, China.

The influence of β-cell function on cardiovascular autonomic neuropathy (CAN), an important diabetes-related complication, is still unclear. In this study, we aimed to investigate the association between residual β-cell function and CAN in patients newly diagnosed with type 2 diabetes. We enrolled 90 newly-diagnosed type 2 diabetic patients and 37 participants with normal glucose tolerance as controls. Read More

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November 2018
3 Reads

Primary tracheal hyalinizing clear cell carcinoma.

Lung Cancer 2018 Nov 14;125:100-102. Epub 2018 Sep 14.

Department of Medicine, Section of Pulmonary, Critical Care, and Sleep Medicine, Virginia Tech Carilion School of Medicine, 1906 Belleview Ave Roanoke VA, 24014, United States.

Hyalinizing clear cell carcinomas (HCCC), now referred to as clear cell carcinomas (CCC) by the World Health Organization (WHO), are rare tumors usually arising from the salivary glands of the head and neck. We present the first case of a CCC originating from the trachea. A 66 year-old woman with history of hypertension, former smoker, presented to the emergency department reporting worsening shortness of breath. Read More

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November 2018
2 Reads

Antitumor effects of β-elemene via targeting the phosphorylation of insulin receptor.

Endocr Relat Cancer 2018 Nov 1. Epub 2018 Nov 1.

L Huang, pathophysiology, Dalian Medical University, Dalian, China.

Ewing sarcoma family tumors (ESFTs) are a group of aggressive and highly metastatic tumors lacking efficient therapies. Insulin-like growth factor 1 receptor (IGF1R) blockade is one of the most efficient targeting therapy for ESFTs. However, the appliance is obstructed by drug resistance and disease recurrence due to the activation of insulin receptor (IR) signaling induced by IGF1R blockade. Read More

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November 2018
4 Reads

Should I trust you? Autistic traits predict reduced appearance-based trust decisions.

Br J Psychol 2018 Nov 13. Epub 2018 Nov 13.

ARC Centre of Excellence in Cognition and its Disorders, School of Psychological Science, University of Western Australia, Crawley, Western Australia, Australia.

Facial impressions of trustworthiness guide social decisions in the general population, as shown by financial lending in economic Trust Games. As an exception, autistic boys fail to use facial impressions to guide trust decisions, despite forming typical facial trustworthiness impressions (Autism, 19, 2015a, 1002). Here, we tested whether this dissociation between forming and using facial impressions of trustworthiness extends to neurotypical men with high levels of autistic traits. Read More

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November 2018
1 Read