1,831 results match your criteria Ewing Sarcoma Imaging


Bone Tumors: Primary Bone Cancers.

Authors:
Lukas Keil

FP Essent 2020 Jun;493:22-26

UNC Orthopaedics, 130 Mason Farm Road CB# 7055, Chapel Hill, NC 27599-7055.

The three most common primary bone cancers are osteosarcoma, Ewing sarcoma, and chondrosarcoma. Osteosarcoma occurs most often in children and young adults, with a peak incidence at ages 10 to 14 years. It also can occur later in life due to malignant transformation of benign bone lesions. Read More

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Challenges in the management of localized Ewing sarcoma in a developing country.

Pediatr Hematol Oncol 2020 Jun 19:1-10. Epub 2020 Jun 19.

Paediatric Haematology Oncology unit, Department of Paediatrics.

Survival in pediatric Ewing sarcoma (ES) lags in low- and middle-income countries (LMICs). This study analyzed factors contributing to a lower outcome in an LMIC center. A retrospective case review of children with localized ES treated from January 2011 till December 2017 was performed. Read More

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http://dx.doi.org/10.1080/08880018.2020.1772912DOI Listing
June 2020
0.963 Impact Factor

Adamantinoma-like Ewing sarcoma of the thyroid.

Diagn Cytopathol 2020 Jun 19. Epub 2020 Jun 19.

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Adamantinoma-like Ewing sarcoma (ALES) is a rare variant of Ewing sarcoma family of tumors (ESFTs). ALES is characterized by translocations of the EWSR1 (Ewing sarcoma breakpoint region 1) gene on chromosome 22, morphologic features of small round blue cell tumors with focal squamous differentiation, and a unique immunoprofile. Herein, we report a 21-year-old patient who presented with severe, acute onset back pain. Read More

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http://dx.doi.org/10.1002/dc.24524DOI Listing

An Fusion Gene in Extraskeletal Undifferentiated Round Cell Sarcoma Expands the Spectrum of Genetic Landscape in the "Ewing-Like" Undifferentiated Round Cell Sarcomas.

Int J Surg Pathol 2020 Jun 7:1066896920929081. Epub 2020 Jun 7.

Department of Pathology & Laboratory Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA.

The molecular findings in Ewing sarcoma have greatly expanded in recent years. Furthermore, this is particularly true for the subset termed "Ewing-like" undifferentiated round cell sarcomas in which new translocations have been reported since the fourth edition of the . Amid this expanding genetic landscape, we report a case of extraskeletal undifferentiated round cell "Ewing-like" sarcoma in a 27-year-old female. Read More

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http://dx.doi.org/10.1177/1066896920929081DOI Listing

Giant primitive neuroectodermal pelvic tumour: a case report and literature review.

J Int Med Res 2020 Jun;48(6):300060520906747

Department of Orthopaedics, Jiangxi Provincial People's Hospital Affiliated to Nanchang University, Nanchang, Jiangxi, China.

Primitive neuroectodermal tumours (PNETs) are rare malignant small round cell tumours. Notably, despite widespread reports of PNET in multiple parts of the body, it is extremely rare in the pelvis. Here, a rare case of giant PNET of the pelvis, that was treated with surgical intervention comprising hemipelvectomy and amputation, is reported. Read More

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http://dx.doi.org/10.1177/0300060520906747DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7278316PMC

PET with F-Fluorodeoxyglucose/Computed Tomography in the Management of Pediatric Sarcoma.

PET Clin 2020 Jul;15(3):333-347

Department of Radiology, Seattle Children's Hospital, M/S MA.7.220, 4800 Sand Point Way Northeast, Seattle, WA 98105, USA. Electronic address:

The role for PET with fludeoxyglucose F 18 (F-FDG PET)/computed tomography (CT) in the management of pediatric sarcomas continues to be controversial. The literature supports a role for PET/CT in the staging and surveillance of certain specific pediatric sarcoma subtypes; however, the data are less clear regarding whether PET/CT can be used as a biomarker for prognostication. Despite the interest in using this imaging modality in the management of pediatric sarcomas, most studies are limited by retrospective design and small sample size. Read More

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http://dx.doi.org/10.1016/j.cpet.2020.03.008DOI Listing

Image-guided core needle biopsy for Ewing sarcoma of bone: a 10-year single-institution review.

Eur Radiol 2020 May 28. Epub 2020 May 28.

The Royal National Orthopaedic Hospital, Brockley Hill, Stanmore, HA7 4LP, UK.

Objective: To evaluate the performance of image-guided core needle biopsy (IGCNB) for the diagnosis of Ewing sarcoma of bone.

Methods: All patients with a confirmed diagnosis of Ewing sarcoma who underwent IGCNB between January 2007 and December 2016 were included in this retrospective study. Analysis included mean age, skeletal distribution, imaging modality used for biopsy guidance, type of anaesthesia, needle type, number of passes, type of tissue sampled, and complications. Read More

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http://dx.doi.org/10.1007/s00330-020-06926-2DOI Listing

Differentiation of Pelvic Osteosarcoma and Ewing Sarcoma Using Radiomic Analysis Based on T2-Weighted Images and Contrast-Enhanced T1-Weighted Images.

Biomed Res Int 2020 11;2020:9078603. Epub 2020 May 11.

Department of Radiology, Peking University People's Hospital, Beijing, China 100044.

Objective: To determine if osteosarcoma (OS) and Ewing sarcoma (EWS) of the pelvis based on MRI can be differentiated using radiomic analysis.

Materials And Methods: In this study, 3.0 T magnetic resonance (MR) data of 66 patients (40 males and 26 females, mean age 27. Read More

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http://dx.doi.org/10.1155/2020/9078603DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240794PMC

Primary spinal intramedullary Ewing-like sarcoma harboring CIC-DUX4 translocation: a similar cytological appearance as its soft tissue counterpart but no lobulation in association with desmoplastic stroma.

Brain Tumor Pathol 2020 Jul 24;37(3):111-117. Epub 2020 May 24.

Department of Pathology, Fujita Health University School of Health Sciences, Toyoake, Aichi, Japan.

The CIC-DUX4 translocation is the most common genetic alteration of small round cell sarcomas without EWSR1 rearrangement. These "Ewing-like sarcomas" usually occur in peripheral soft tissues, and rare primary central nervous system (CNS) tumors have been described. We report a rare case of primary spinal intramedullary Ewing-like sarcoma harboring CIC-DUX4 translocation. Read More

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http://dx.doi.org/10.1007/s10014-020-00366-yDOI Listing

Primary Extraosseous Ewing Sarcoma of the Thoracic Spine Presenting as Chest Pain Mimicking Spinal Schwannoma.

World Neurosurg 2020 May 21. Epub 2020 May 21.

Department of Pathology, Chonnam National University Medical School & Research Institute of Medical Sciences, Gwangju, Korea.

Background: Extraosseous Ewing sarcoma (EES) usually has a pseudocapsule and high vascularity, making it well circumscribed and focally dense with contrast enhancement on magnetic resonance imaging (MRI). Consequently, it is difficult to diagnose and distinguish from other spinal tumors, based on pretreatment radiologic findings alone. Here, we present a case of EES involving the thoracic spinal column, which was suspected to be spinal schwannoma through pretreatment radiologic findings. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.05.130DOI Listing

Mechanisms of Efficacy of the FGFR1-3 Inhibitor AZD4547 in Pediatric Solid Tumor Models.

Invest New Drugs 2020 May 20. Epub 2020 May 20.

Department of Pediatrics, Division of Hematology-Oncology, University of California San Diego, 3855 Health Sciences Dr., MC 0815, La Jolla, CA, 92093, USA.

Children with aggressive pediatric solid tumors have poor outcomes and novel treatments are needed. Pediatric solid tumors demonstrate aberrant expression and activity of the fibroblast growth factor receptor (FGFR) family, suggesting FGFR inhibitors may be effective therapeutic agents. AZD4547 is a multikinase inhibitor of the FGFR1-3 kinases, and we hypothesized that AZD4547 would be effective in pediatric solid tumor preclinical models. Read More

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http://dx.doi.org/10.1007/s10637-020-00933-2DOI Listing

Adrenalectomy during pregnancy: A 15-year experience at a tertiary referral center.

Surgery 2020 May 17. Epub 2020 May 17.

Department of Digestive, Hepato-biliary and Endocrine Surgery, Referral Center for Rare Adrenal Diseases, Cochin Hospital, APHP, Paris, France; Faculté de Médecine Paris Descartes, Université Paris Descartes, Sorbonne Paris Cité, France; INSERM Unité 1016, Centre National de la Recherche Scientifique Unité Mixte de Recherche 8104, Institut Cochin, Paris, France.

Background: Adrenal lesions diagnosed during pregnancy remain rare, and their management is challenging because of maternal physiologic modifications, restricted imaging investigations, and contraindications to several treatments. Surgical issues of adrenalectomy during pregnancy and consequences on perinatal outcomes are poorly described. We therefore aimed to report maternal and fetal outcomes after adrenalectomy during pregnancy. Read More

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http://dx.doi.org/10.1016/j.surg.2020.03.019DOI Listing

Bone marrow involvement in pediatric malignancies: a comparison study of Positron emission tomographycomputed tomography and bone marrow biopsy.

Turk J Pediatr 2020 ;62(2):182-190

Departments of Pediatrics, Mersin University Faculty of Medicine, Mersin, Turkey.

Background And Objectives: The comparison of Positron emission tomography- computed tomography (PETCT) and bone marrow biopsy (BMB) modalities in detecting bone marrow disease is an up to date research topic. In this study, we aimed to compare the results of PET-CT and BMB procedures in detecting bone marrow involvement in pediatric malignancies.

Method: At the time of diagnosis, PET-CT imaging and BMB performed patients` data were evaluated, retrospectively. Read More

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http://dx.doi.org/10.24953/turkjped.2020.02.003DOI Listing
January 2020

Phase II trial of gemcitabine and nab-paclitaxel in patients with recurrent Ewing sarcoma: A report from the National Pediatric Cancer Foundation.

Pediatr Blood Cancer 2020 Jul 9;67(7):e28370. Epub 2020 May 9.

Division of Pediatric Hematology-Oncology, Duke Children's Hospital and Health Center, Durham, North Carolina.

Background: The combination of gemcitabine and docetaxel is often used to treat patients with recurrent sarcoma. Nab-paclitaxel is a taxane modified to improve drug exposure and increase intratumoral accumulation and, in combination with gemcitabine, is standard therapy for pancreatic cancer. Applying the dosages and schedule used for pancreatic cancer, we performed a phase II trial to assess the response rate of gemcitabine and nab-paclitaxel in patients with relapsed Ewing sarcoma. Read More

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http://dx.doi.org/10.1002/pbc.28370DOI Listing

Ewing Sarcoma presenting as a gluteal mass in adult woman: Diagnostic approach and its challenges.

Malays J Pathol 2020 Apr;42(1):121-125

Universiti Sains Malaysia, School of Medical Sciences, Department of Pathology, Health Campus, Kelantan, Malaysia.

Introduction: Sarcomas of the Ewing family of tumours are aggressive neoplasms occurring in bone and soft tissue of mostly children and young adults. It usually affects male more than female with peak incidence 10 to 15 years of age, and rarely encountered in adults especially in more than 40 years old. It is an aggressive, rare tumour with a tendency toward recurrence after resection and early metastasis. Read More

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Development of disease-modifying drugs for frontotemporal dementia spectrum disorders.

Nat Rev Neurol 2020 04 23;16(4):213-228. Epub 2020 Mar 23.

Department of Research and Development, Chiesi Farmaceutici, Parma, Italy.

Frontotemporal dementia (FTD) encompasses a spectrum of clinical syndromes characterized by progressive executive, behavioural and language dysfunction. The various FTD spectrum disorders are associated with brain accumulation of different proteins: tau, the transactive response DNA binding protein of 43 kDa (TDP43), or fused in sarcoma (FUS) protein, Ewing sarcoma protein and TATA-binding protein-associated factor 15 (TAF15) (collectively known as FET proteins). Approximately 60% of patients with FTD have autosomal dominant mutations in C9orf72, GRN or MAPT genes. Read More

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http://dx.doi.org/10.1038/s41582-020-0330-xDOI Listing
April 2020
15.358 Impact Factor

The Optimal Outcome of Suppressing Ewing Sarcoma Growth With Biocompatible Bioengineered miR-34a-5p Prodrug.

Front Oncol 2020 25;10:222. Epub 2020 Feb 25.

Department of Orthopedics Trauma and Microsurgery, Zhongnan Hospital of Wuhan University, Wuhan, China.

Being the second most common type of primary bone malignancy in children and adolescents, Ewing Sarcoma (ES) encounters the dilemma of low survival rate with a lack of effective treatments. As an emerging approach to combat cancer, RNA therapeutics may expand the range of druggable targets. Since the genome-derived oncolytic microRNA-34a (miR-34a) is down-regulated in ES, restoration of miR-34a-5p expression or function represents a new therapeutic strategy which is, however, limited to the use of chemically-engineered miRNA mimics. Read More

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http://dx.doi.org/10.3389/fonc.2020.00222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7052494PMC
February 2020

A Nonpediatric Extraosseous Ewing Sarcoma of the Pancreas: Differential Diagnosis and Therapeutic Strategies.

Case Rep Oncol Med 2020 30;2020:2792750. Epub 2020 Jan 30.

Department of Internal Medicine, Texas Health Presbyterian Hospital Dallas, Texas 75231, USA.

Extraosseous Ewing's sarcoma is a rare and aggressive malignant tumor with a poor prognosis. The pancreas is an extremely uncommon primary site, with only 27 cases that have been published worldwide. We report a 26-year-old female who presented with 5 days of left upper quadrant pain, nausea, and vomiting. Read More

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http://dx.doi.org/10.1155/2020/2792750DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7013316PMC
January 2020

Cabozantinib in patients with advanced Ewing sarcoma or osteosarcoma (CABONE): a multicentre, single-arm, phase 2 trial.

Lancet Oncol 2020 03 17;21(3):446-455. Epub 2020 Feb 17.

Department of Medicine, Centre Leon Berard, Lyon, France.

Background: Patients with Ewing sarcoma or osteosarcoma have a median overall survival of less than 12 months after diagnosis, and a standard treatment strategy has not yet been established. Pharmacological inhibition of MET signalling and aberrant angiogenesis has shown promising results in several preclinical models of Ewing sarcoma and osteosarcoma. We aimed to investigate the activity of cabozantinib, an inhibitor of MET and VEGFR2, in patients with advanced Ewing sarcoma and osteosarcoma. Read More

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http://dx.doi.org/10.1016/S1470-2045(19)30825-3DOI Listing

Left renal Ewing's sarcoma: A case study and a review of imaging literature.

Radiol Case Rep 2020 Apr 7;15(4):391-395. Epub 2020 Feb 7.

Department of Oncology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran.

Extra-skeletal Ewing's sarcoma is among the rarest tumors in adults. The primary sites of the tumor dictates symptoms and signs, thus early treatments are compromised when more common tumors are lined up as differentials by the location. We present a case of a 35-year-old pregnant female who developed a renal Ewing sarcoma during pregnancy. Read More

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http://dx.doi.org/10.1016/j.radcr.2020.01.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7013146PMC

Correction to: Assessment of treatment responses in children and adolescents with Ewing sarcoma with metabolic tumor parameters derived from F-FDG-PET/CT and circulating tumor DNA.

Eur J Nucl Med Mol Imaging 2020 Jun;47(6):1613

Department of Pediatrics and Adolescent Medicine, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Erlangen, Germany.

The author names and family names of the originally published article was inversed. Correct presentation is presented here. Read More

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http://dx.doi.org/10.1007/s00259-019-04672-2DOI Listing

Manual and semiautomatic segmentation of bone sarcomas on MRI have high similarity.

Braz J Med Biol Res 2020 31;53(2):e8962. Epub 2020 Jan 31.

Departamento de Imagens Médicas, Hematologia e Oncologia Clínica, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brasil.

The aims of this study were to evaluate the intra- and interobserver reproducibility of manual segmentation of bone sarcomas in magnetic resonance imaging (MRI) studies and to compare manual and semiautomatic segmentation methods. This retrospective study included twelve osteosarcoma and eight Ewing sarcoma MRI studies performed prior to any therapeutic intervention. All cases were histopathologically confirmed. Read More

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http://dx.doi.org/10.1590/1414-431X20198962DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6993358PMC

The value of diffusion weighted imaging and apparent diffusion coefficient in primary Osteogenic and Ewing sarcomas for the monitoring of response to treatment: Initial experience.

Eur J Radiol 2020 Mar 28;124:108855. Epub 2020 Jan 28.

Department of Radiology, American University of Beirut Medical Center, Riad El-Solh 1107 2020, PO Box: 11-0236, Beirut, Lebanon. Electronic address:

Purpose: To assess the value of using Apparent Diffusion Coefficient (ADC) mapping in Diffusion Weighted Imaging (DWI) when monitoring treatment response in pediatric Osteogenic and Ewing sarcomas and to correlate with level of necrosis on post-surgical excision pathology.

Method: This retrospective study includes 7 Osteosarcoma and 8 Ewing sarcoma patients. Pre-treatment and post-treatment focal MRIs were evaluated for ADC values, tumor volumes and variability of both measurements. Read More

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http://dx.doi.org/10.1016/j.ejrad.2020.108855DOI Listing

Aggressive Local Control With Multisite Stereotactic Body Radiation in Metastatic Ewing Sarcoma: A Literature Review and Case Report.

Anticancer Res 2020 Feb;40(2):951-955

Department of Radiation Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, U.S.A.

Ewing sarcoma (ES) is an undifferentiated small round blue cell tumor most commonly originating in the bone of adolescents 10-20 years of age, although 30% are diagnosed in adults. The most important prognostic factor is the presence of metastatic disease. Results of the EURO-EWING 99 trial of ES patients showed that local treatment of not only the primary, but also of the sites of metastatic disease should be considered to improve event-free survival. Read More

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http://dx.doi.org/10.21873/anticanres.14028DOI Listing
February 2020

Clinical impact of post-induction resolution of pulmonary lesions in metastatic Ewing sarcoma.

Pediatr Blood Cancer 2020 04 15;67(4):e28150. Epub 2020 Jan 15.

Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee.

Background: Patients with metastatic Ewing sarcoma experience poor outcomes despite intensive systemic and local therapy. Early chemotherapy response of pulmonary metastases has been associated with prognosis in other pediatric malignancies. We reviewed the outcomes of patients with Ewing sarcoma and pulmonary metastases treated at our institution based on therapy received and early pulmonary response. Read More

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http://dx.doi.org/10.1002/pbc.28150DOI Listing

The incidence of skip metastases on whole bone MRI in high-grade bone sarcomas.

Skeletal Radiol 2020 Jun 9;49(6):945-954. Epub 2020 Jan 9.

Department of Imaging, Royal National Orthopaedic Hospital, Stanmore, UK.

Introduction: Skip metastases have been described with osteosarcoma, Ewing sarcoma and rarely chondrosarcoma. The aim of this study was to determine the incidence of skip metastases on whole bone MRI in all primary high-grade sarcomas of the major long bones.

Materials And Method: Retrospective review of patients from April 2007 to April 2019 with high-grade primary bone sarcomas of the humerus, radius, ulna, femur, tibia or fibula who had whole bone MRI at initial staging. Read More

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http://dx.doi.org/10.1007/s00256-019-03369-9DOI Listing

Routine Surveillance Imaging Is Associated with Improved Postrelapse Survival in Patients with Ewing Sarcoma.

J Adolesc Young Adult Oncol 2020 Jun 9;9(3):394-401. Epub 2020 Jan 9.

Department of Pediatric Hematology/Oncology, Nemours Children's Specialty Care and Wolfson Children's Hospital, Jacksonville, Florida, USA.

Children with Ewing sarcoma (ES) routinely undergo surveillance imaging after completion of therapy; however, the medical benefit of this imaging remains unclear. We aimed to determine whether there is a difference in survival between patients whose relapse was detected based on development of new symptoms or by routine imaging. We retrospectively reviewed all patients consecutively diagnosed with ES at Children's Healthcare of Atlanta from 2000 to 2011. Read More

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http://dx.doi.org/10.1089/jayao.2019.0131DOI Listing

Primary bone sarcoma with BCOR internal tandem duplication.

Virchows Arch 2020 Jun 3;476(6):915-920. Epub 2020 Jan 3.

Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, TN, USA.

BCOR internal tandem duplications (ITDs) and rearrangements are implicated in the oncogenesis of a subset of undifferentiated sarcomas. To date, BCOR ITD sarcomas have been exclusively found in non-appendicular infantile soft tissues, whereas BCOR-rearranged sarcomas occur in both bones and soft tissues affecting a wider patient age range. Little is known about patient outcome in BCOR ITD sarcomas. Read More

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http://dx.doi.org/10.1007/s00428-019-02729-zDOI Listing

The long-term results of extendable endoprostheses of the humerus in children after the resection of a bone sarcoma.

Bone Joint J 2020 Jan;102-B(1):64-71

Royal Orthopaedic Hospital, Birmingham, UK.

Aims: The purpose of this study was to report the long-term results of extendable endoprostheses of the humerus in children after the resection of a bone sarcoma.

Methods: A total of 35 consecutive patients treated with extendable endoprosthetic replacement of the humerus in children were included. There were 17 boys and 18 girls in the series with a median age at the time of initial surgery of nine years (interquartile range (IQR) 7 to 11). Read More

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http://dx.doi.org/10.1302/0301-620X.102B12.BJJ-2020-0124.R1DOI Listing
January 2020

FDG PET/CT of Primary Ewing Sarcoma of IVC.

Clin Nucl Med 2020 Feb;45(2):e112-e114

From the Department of Nuclear Medicine and Molecular Imaging, Tata Memorial Hospital, Mumbai, India.

Secondary involvement of inferior vena cava is a common presentation in aggressive solid malignancies, especially arising from kidneys, adrenals, and hepatobiliary system, mostly resulting from local infiltration. Rarely, primary tumors are seen arising from vascular tissue. The Ewing family of tumors commonly arises from bone, but there is a high propensity of these tumors to originate from nonosseous sites of mesenchymal cell origin. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002878DOI Listing
February 2020

Primary Ewing Sarcoma/Primitive Neuroectodermal Tumor of Kidney With Inferior Vena Cava Thrombus: Findings on 18F-FDG PET/CT.

Clin Nucl Med 2020 Feb;45(2):e103-e105

Medical Oncology.

Primary Ewing sarcoma/primitive neuroectodermal tumor is a group of rare aggressive tumors in adults derived from neuroectoderm, and primary renal involvement is extremely rare. We describe an F-FDG PET/CT findings of a 28-year-old man who presented with left renal mass with inferior vena cava thrombus, which turned out to be primary Ewing sarcoma on histopathology specimen post left nephrectomy. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002865DOI Listing
February 2020
3.931 Impact Factor

Assessment of treatment responses in children and adolescents with Ewing sarcoma with metabolic tumor parameters derived from F-FDG-PET/CT and circulating tumor DNA.

Eur J Nucl Med Mol Imaging 2020 Jun 18;47(6):1564-1575. Epub 2019 Dec 18.

Department of Pediatrics and Adolescent Medicine, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Erlangen, Germany.

Purpose: The purpose of this study was to perform a prospective integrated analysis of F-fluorodeoxyglucose (F-FDG)-positron emission tomography (PET)/computed tomography (CT) and circulating tumor DNA (ctDNA) to assess responses to multimodal chemotherapy in children and adolescents suffering from Ewing sarcoma (EwS).

Methods: A total of 20 patients with histologically confirmed EwS underwent multiple F-FDG-PET/CT, performed at the time of each patient's initial diagnosis and after the second and fifth induction chemotherapy block (EWING2008 treatment protocol, NCT00987636). Additional PET examinations were performed as clinically indicated in some patients, e. Read More

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http://dx.doi.org/10.1007/s00259-019-04649-1DOI Listing

Total Femur Replacement Using a Humeral Reconstruction Component in a 36-month-Old Ewing Sarcoma Patient.

Isr Med Assoc J 2019 Dec;12(21):833-834

Department of Orthopedics and Tumor Orthopedics, University Hospital Muenster, Muenster, Germany.

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December 2019

Ewing's sarcoma/primitive neuroectodermal tumor of the kidney: a case report and literature review.

Transl Androl Urol 2019 Oct;8(5):562-566

Department of Radiology, Sichuan University West China Hospital, Chengdu 610041, China.

Ewing sarcoma/primitive neuroectodermal tumor (ES/PNET) is a malignant bone, and soft-tissue tumor derived from neuroectoderm. It occurs in pediatric adolescents with the histopathological features of invasiveness. Renal involvement is extremely rare, which is limited to case reports and small case series. Read More

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http://dx.doi.org/10.21037/tau.2019.09.46DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6842790PMC
October 2019

Ewing's sarcoma in the spinal canal of T12-L3: A case report and review of the literature.

Oncol Lett 2019 Dec 3;18(6):6157-6163. Epub 2019 Oct 3.

Neurosurgical Research Institute, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, Guangdong 510060, P.R. China.

Primary Ewing's sarcoma (ES) is rare, especially when it occurs in the spinal canal during middle or old age. The rarity of Ewing's sarcoma breakpoint region 1 fusion-negative ES has been reported in the literature. The present case report describes a 60-year-old Chinese patient who was diagnosed with ES originating from the spinal canal in 2016. Read More

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http://dx.doi.org/10.3892/ol.2019.10958DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6865001PMC
December 2019

A Novel Method to Prevent Terminal Appositional Overgrowth Following Pediatric Below Knee Amputations A Case Series and Review of the Literature.

Bull Hosp Jt Dis (2013) 2019 Dec;77(4):269-274

The terminal overgrowth of the tibia following pediatric transtibial amputation is a common problem leading to pain, disability, and repeat surgical procedures. We present three patients who underwent transtibial amputation due to sarcoma of the lower extremity followed by compress osseointegration prosthesis fixation. The minimum follow-up was 1 year. Read More

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December 2019

Extra-skeletal Ewing Sarcoma of the chest wall in a child.

SA J Radiol 2019 27;23(1):1733. Epub 2019 Jun 27.

Department of Radiology, Rahima Moosa Mother and Child Hospital, University of the Witwatersrand, Johannesburg, South Africa.

Chest wall or pleural-based tumours represent a heterogeneous group of lesions that are infrequent in children and infants; however, a large proportion of these lesions are malignant in nature. Categorising them on the basis of primary versus secondary, site of origin (osseous and cartilage, or soft tissue) and tissue composition may assist in narrowing the differential diagnosis. We present a case of a 7-year-old boy with a progressive history of dyspnoea. Read More

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http://dx.doi.org/10.4102/sajr.v23i1.1733DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6837769PMC

Primary Ewing sarcoma of the adrenal gland: A rare cause of abdominal mass.

Radiol Case Rep 2020 Jan 6;15(1):1-6. Epub 2019 Nov 6.

Department of Radiology, SUNY Upstate University hospital, 750 East Adams Street, Syracuse, NY, 13210, USA.

Ewing sarcoma is a malignant tumor that more commonly affects the long bones. Primary Ewing sarcoma of the adrenal gland is a rare diagnosis. We report an unusual case of primary Ewing sarcoma of the adrenal gland in a 34-year-old man who initially presented with abdominal as well as flank pain and abdominal mass. Read More

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http://dx.doi.org/10.1016/j.radcr.2019.09.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6849434PMC
January 2020

Evaluating low back pain in adolescents.

JAAPA 2019 Dec;32(12):14-20

Sarah J. Garvick is associate program director of the PA program at the Boone, N.C., campus of Wake Forest School of Medicine. Candice Creecy, Megan Miller, Lorae Schafer, Alex Spooner, and Ann Wallace Tazewell were students in the PA program at Wake Forest School of Medicine in Winston-Salem, N.C., when this article was written. Tanya Gregory is an assistant professor and director of student services in the PA program at Wake Forest School of Medicine in Winston-Salem. The authors have disclosed no potential conflicts of interest, financial or otherwise.

Low back pain in adolescents is a common complaint in primary care. With an average prevalence rate of 40%, adolescent low back pain correlates with greater healthcare use, higher incidences of adult back pain, and negative effects on overall well-being. A thorough history and physical examination can increase early detection and accurate diagnosis while ensuring the judicious use of diagnostic modalities. Read More

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http://dx.doi.org/10.1097/01.JAA.0000604852.26078.91DOI Listing
December 2019

Ewing-like sarcoma/undifferentiated round cell sarcoma in an infant with APC and MSH6 variation: A case report.

Medicine (Baltimore) 2019 Nov;98(45):e17872

Pathology & Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, CA.

Rationale: Ewing-like sarcoma (ELS)/undifferentiated round cell sarcoma (URCS) is a rare type of soft tissue sarcomas (STS), especially in infants, with poor prognosis. It is a so-called "small round cell" sarcoma, and has many features of Ewing sarcoma, but lacks rearrangements in EWSR1. The diagnosis and treatment of this kind of STS remains challenging. Read More

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http://dx.doi.org/10.1097/MD.0000000000017872DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6855612PMC
November 2019

Chronic non-bacterial osteomyelitis of clavicle.

Postgrad Med J 2019 Dec 25;95(1130):680-681. Epub 2019 Oct 25.

Pathology Department, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran

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http://dx.doi.org/10.1136/postgradmedj-2019-137110DOI Listing
December 2019
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EWS-FLI1-mediated tenascin-C expression promotes tumour progression by targeting MALAT1 through integrin α5β1-mediated YAP activation in Ewing sarcoma.

Br J Cancer 2019 11 25;121(11):922-933. Epub 2019 Oct 25.

Spinal Tumor Center, Department of Orthopaedic Oncology, Changzheng Hospital, Second Military Medical University, Shanghai, 200003, P. R. China.

Background: The extracellular matrix has been critically associated with the tumorigenesis and progression of Ewing sarcoma (ES). However, the regulatory and prognostic roles of tenascin-C (TNC) in ES remain unclear.

Methods: TNC expression was examined in specimens by immunohistochemistry, and the association of TNC expression with ES patient survival was also analysed. Read More

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http://dx.doi.org/10.1038/s41416-019-0608-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889507PMC
November 2019
4.836 Impact Factor

Primary Ewing's sarcoma of the temporal bone: a rare entity and review of the literature.

BMJ Case Rep 2019 Oct 23;12(10). Epub 2019 Oct 23.

Surgical Oncology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.

Ewing's sarcoma (ES) is the second most common malignant primary bone tumour in children and adolescents. It primarily affects the diaphysis of long bones and pelvis. ES arising from temporal bone is extremely rare. Read More

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http://dx.doi.org/10.1136/bcr-2019-230768DOI Listing
October 2019

Functional and anatomical imaging in pediatric oncology: which is best for which tumors.

Authors:
Stephan D Voss

Pediatr Radiol 2019 10 16;49(11):1534-1544. Epub 2019 Oct 16.

Department of Radiology, Boston Children's Hospital, Harvard Medical School, 300 Longwood Ave, Boston, MA, 02115, USA.

Functional imaging techniques are playing an increasingly important role in the management of pediatric cancer. Technological advances have pushed the development of hybrid imaging techniques, including positron emission tomography (PET)/CT, PET/MR and single-photon emission computed tomography (SPECT)/CT. Together with an increasing need to identify surrogate biomarkers for response to novel therapies, the use of functional imaging techniques, which had been reserved primarily for lymphoma patients, is now being recognized as standard of care for the management of many other pediatric solid tumors. Read More

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http://dx.doi.org/10.1007/s00247-019-04489-zDOI Listing
October 2019
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Primary Pediatric Renal Primitive Neuroectodermal Tumor: A Case Report With Different Stage CT and MRI Images.

Urology 2020 Feb 9;136:241-244. Epub 2019 Oct 9.

Department of Urology, The First Hospital of Jilin University, Changchun 130021, China. Electronic address:

Ewing sarcoma/primitive neuroectodermal tumor (ES/PNET) of the kidney in children younger than 10 years of age is extremely rare. We describe here the case of a 7-year-old female patient who was diagnosed with ES/PNET. The timeframe for this case spanned from 8 months prior to diagnosis until 8 months postsurgical removal of the tumor. Read More

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http://dx.doi.org/10.1016/j.urology.2019.09.032DOI Listing
February 2020

Primary Ewing's Sarcoma of Maxillary sinus: A Case Report.

Gulf J Oncolog 2019 Sep;1(31):78-82

Mahavir Cancer Sansthan, Patna, Bihar, India.

Ewing's sarcoma are small round cell tumors belonging to Ewing's family of tumors and the second most common bone tumor seen in children. The most common affected sites are long bones of extremities followed by pelvis and ribs. Primary arising in head and neck region is uncommon and maxillary Ewing's sarcoma is rarely seen. Read More

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September 2019

Which Factors Are Associated with Local Control and Survival of Patients with Localized Pelvic Ewing's Sarcoma? A Retrospective Analysis of Data from the Euro-EWING99 Trial.

Clin Orthop Relat Res 2020 02;478(2):290-302

D. Andreou, G. Gosheger, Department of General Orthopedics and Tumor Orthopedics, University Hospital Münster, Westfälische Wilhelms-University, Münster, Germany A. Ranft, U. Dirksen, Pediatrics III, Hematology/Oncology, West German Cancer Center, University Hospital Essen, Essen, Germany B. Timmermann, Clinic for Particle Therapy, West German Proton Therapy Center, University Hospital Essen, Essen, Germany R. Ladenstein, Department of Studies and Statistics on Integrated Research and Projects (S2IRP), Children's Cancer Research Institute, Vienna, Austria W. Hartmann, E. Wardelmann, Gerhard-Domagk-Institute for Pathology, University Hospital Münster, Westfälische Wilhelms-University, Münster, Germany S. Bauer, Department of Medical Oncology, Sarcoma Center, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany D. Baumhoer, Bone Tumor Reference Center, Institute of Pathology, University Hospital Basel, University of Basel, Basel, Switzerland H. van den Berg, Department of Pediatric Oncology, Emma Children's Hospital/Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands P. D. S. Dijkstra, Department of Orthopedic Surgery, Leiden University Medical Center, Leiden, the Netherlands H. R. Dürr, Orthopedic Oncology, Department of Orthopedics, Ludwig-Maximilians University Munich, Campus Grosshadern, Munich, Germany H. Gelderblom, Department of Medical Oncology, Leiden University Medical Center, Leiden, the Netherlands J. Hardes, A Streitbürger, Department of Tumor Orthopedics and Sarcoma Surgery, University Hospital Essen, Essen, Germany L. Hjorth, Department of Paediatrics, Skane University Hospital, Clinical Sciences, Lund University, Lund, Sweden J. Kreyer, Department of Orthopedic and Trauma Surgery, University Hospital Essen, University of Duisburg-Essen, Essen, Germany J. Kruseova, Department of Pediatric Hematology and Oncology, 2nd Medical School, Charles University Prague, Prague, Czech Republic A. Leithner, Department of Orthopedic Surgery, Medical University of Graz, Graz, Austria S. Scobioala, Department of Radiation Oncology, University Hospital Münster, Westfälische Wilhelms-University, Münster, Germany P-U. Tunn, Department of Orthopedic Oncology, HELIOS Klinikum Berlin-Buch, Berlin, Germany R. Windhager, Department of Orthopedics, Medical University of Vienna, Vienna, Austria H. Jürgens, Department of Paediatric Hematology and Oncology, University Hospital Münster, Westfälische Wilhelms-University, Münster, Germany.

Background: Local treatment of pelvic Ewing's sarcoma may be challenging, and intergroup studies have focused on improving systemic treatments rather than prospectively evaluating aspects of local tumor control. The Euro-EWING99 trial provided a substantial number of patients with localized pelvic tumors treated with the same chemotherapy protocol. Because local control included surgical resection, radiation therapy, or a combination of both, we wanted to investigate local control and survival with respect to the local modality in this study cohort. Read More

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http://dx.doi.org/10.1097/CORR.0000000000000962DOI Listing
February 2020
9 Reads

Primary Ewing sarcoma of the larynx with distant metastasis: a case report and review of the literature.

Curr Oncol 2019 08 1;26(4):e574-e577. Epub 2019 Aug 1.

Department of Otolaryngology Head and Neck Surgery, American University of Beirut Medical Center, Beirut, Lebanon.

Extraosseous Ewing sarcoma is a rare, poorly differentiated round-cell tumour that is part of the Ewing sarcoma family of tumours. Here, we present an extremely rare case of primary extraosseous Ewing sarcoma arising in the larynx, with distant metastases. A 53-year-old man with a history of Hodgkin lymphoma treated 4 years earlier with 8 cycles of chemotherapy presented to our medical centre with a 2-week history of hoarseness. Read More

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http://dx.doi.org/10.3747/co.26.5001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726258PMC
August 2019
3 Reads

Selective Accumulation of Galactomannan Amphiphilic Nanomaterials in Pediatric Solid Tumor Xenografts Correlates with Gene Expression.

ACS Appl Mater Interfaces 2019 Oct 10;11(42):38483-38496. Epub 2019 Oct 10.

Laboratory of Pharmaceutical Nanomaterials Science, Department of Materials Science and Engineering , Technion-Israel Institute of Technology , Haifa 3200003 , Israel.

In this work, we designed, characterized, and investigated the performance of hydrolyzed galactomannan (hGM)-based amphiphilic nanoparticles for selective intratumoral accumulation in pediatric patient-derived sarcomas. To create a self-assembly amphiphilic copolymer, the side chain of hGM was hydrophobized with poly(methyl methacrylate) (PMMA) by utilizing a graft free radical polymerization reaction. Different hGM and MMA weight feeding ratios were used to adjust the critical aggregation concentration and the size and size distribution of the nanoparticles. Read More

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http://dx.doi.org/10.1021/acsami.9b12682DOI Listing
October 2019
1 Read