2,030 results match your criteria Ewing Sarcoma Imaging


Interventional Radiology in the Management of Metastases and Bone Tumors.

J Clin Med 2022 Jun 7;11(12). Epub 2022 Jun 7.

San Salvatore Hospital, 67100 L'Aquila, Italy.

Interventional Radiology (IR) has experienced an exponential growth in recent years. Technological advances of the last decades have made it possible to use new treatments on a larger scale, with good results in terms of safety and effectiveness. In musculoskeletal field, painful bone metastases are the most common target of IR palliative treatments; however, in selected cases of bone metastases, IR may play a curative role, also in combination with other techniques (surgery, radiation and oncology therapies, etc. Read More

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Intracranial extraosseous dural-based Ewing's sarcoma with fluid-haematocrit levels: imaging findings of a rare tumour.

BMJ Case Rep 2022 Jun 14;15(6). Epub 2022 Jun 14.

Radiodiagnosis, All India Institute of Medical Sciences Bhubaneswar, Bhubaneswar, Odisha, India.

Extraosseous dural-based primary Ewing's sarcoma of the central nervous system is a rare tumour posing a diagnostic challenge. On cross-sectional radiological imaging, the lesion has an extra-axial location with heterogeneous appearance. These lesions are usually multicystic with internal haemorrhage causing fluid-haematocrit levels. Read More

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Adamantinoma-Like Ewing Sarcoma of the Mandible Evaluated on 18F-FDG PET/CT.

Clin Nucl Med 2022 Jul 5;47(7):635-637. Epub 2022 Apr 5.

From the Departments of Radiology.

Abstract: Ewing sarcoma is the second most common primary bone tumor in children. Typical Ewing sarcoma most frequently occurs in long bones and within the pelvis. ALES (adamantinoma-like Ewing sarcoma) is a rare subtype of Ewing sarcoma that is characterized by epithelial differentiation in addition to small round blue cells. Read More

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Primary ewing sarcoma in the uterine cervix with multiple bone metastases.

Arch Gynecol Obstet 2022 Jun 3. Epub 2022 Jun 3.

Department of Obstetrics and Gynecology, Peking University First Hospital, No. 1 Xi'an men Street, Xicheng District, Beijing, 100034, China.

A 45-year-old female (G1, P1) with HPV-52 infection and low-grade cervical cytology presented to our clinic with an asymptomatic cervical mass. She suffered amenorrhea for the past 3 years due to medication for thyroid cancer. Magnetic resonance imaging revealed a mass sized 7. Read More

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Sarcoma Happens: A Reminder for Arthroscopic Surgeons.

Cureus 2022 Apr 25;14(4):e24457. Epub 2022 Apr 25.

Orthopaedic Surgery, Johns Hopkins University, Baltimore, USA.

Primary intra-articular sarcomas are rare and present with nonspecific symptoms such as pain or swelling. Due to nonspecific symptoms, patients may undergo routine diagnostic arthroscopy, which ultimately leads to sarcoma diagnosis. Here we present four patients with intra-articular sarcomas of the knee diagnosed after arthroscopy. Read More

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Ewing's sarcoma in scapula, epidemiology, clinical manifestation, diagnosis and treatment: A literature review.

Ann Med Surg (Lond) 2022 May 11;77:103617. Epub 2022 Apr 11.

Department of Orthopedic, Aleppo University Hospital, Aleppo, Syria.

Background: Ewing's sarcoma (ES) can affect any bone, but its occurrence in the scapula is extremely rare. Only 15 studies investigating this condition exist in the medical literature.

Materials And Methods: A literature search was conducted in PubMed and Scopus, and studies on ES of scapula published in the English medical literature were retrieved. Read More

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Extraskeletal Ewing Sarcoma from Head to Toe: Multimodality Imaging Review.

Radiographics 2022 May 27:210226. Epub 2022 May 27.

From the Department of Abdominal Imaging, The University of Texas MD Anderson Cancer Center, 1400 Pressler St, Houston, TX 77030 (A.W., M.B., B.R.K., K.M.E.); Department of Radiology, Mayo Clinic, Jacksonville, Fla (M.D., C.W.B.); Department of Radiology, The University of Texas Health Science Center at Houston, Tex (J.G.); Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wis (P.J.P., M.G.L.); Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (V.M.M.); and Department of Laboratory Medicine and Pathology, Mayo Clinic, Scottsdale, Ariz (L.C.).

Extraskeletal Ewing sarcoma (EES) is a rare subtype in the Ewing sarcoma family of tumors (ESFT), which also includes Ewing sarcoma of bone (ESB) and, more recently, primitive neuroectodermal tumors. Although these tumors often have different manifestations, they are grouped on the basis of common genetic translocation and diagnosis from specific molecular and immunohistochemical features. While the large majority of ESFT cases occur in children and in bones, approximately 25% originate outside the skeleton as EES. Read More

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Total calcaneal allograft reconstruction of an Ewing's sarcoma in a child: Outcome and review of the literature.

Cancer Rep (Hoboken) 2022 May 18:e1626. Epub 2022 May 18.

Pediatric Department of Traumatology and Orthopedic Surgery, Hospital Sant Joan de Deu, Universitat De Barcelona, Barcelona, Spain.

Background: Ewing's sarcoma rarely presents in bones of the feet. Surgical management usually includes amputation. Limb sparing surgery is anecdotal. Read More

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Radiation Therapy Dose Escalation in Unresectable Ewing Sarcoma: Final Results of a Phase 3 Randomized Controlled Trial.

Int J Radiat Oncol Biol Phys 2022 May 11. Epub 2022 May 11.

Department of Pediatric Oncology, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, India.

Purpose: Our aim was to assess the effect of radiation therapy (RT) dose escalation on outcomes in surgically unresectable Ewing sarcoma (ES)/primitive neuroectodermal tumor (PNET).

Methods And Materials: Patients with nonmetastatic unresectable ES/PNET (excluding intracranial/chest wall) receiving vincristine, doxorubicin, cyclophosphamide, ifosfamide, and etoposide chemotherapy, planned for definitive RT, were accrued in this single-institution, open-label, phase 3 randomized controlled trial. Randomization was between standard dose RT (SDRT; 55. Read More

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[Cervical Primary Ewing's Sarcoma:Report of One Case].

Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2022 Apr;44(2):348-351

Department of Radiology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.

Ewing's sarcoma in the cervix is characterized by extremely rare occurrence,high degree of malignancy,and rapid progression.The diagnosis of this disease is based on pathology and immunohistochemistry. The main image of the case reported in this paper showed the cervical cyst with solid mass,large volume,and uneven density and signal,and the solid part can be strengthened in enhanced scanning. Read More

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Prognostic value of fluorodeoxyglucose positron emission tomography derived metabolic parameters and textural features in pediatric sarcoma.

Nucl Med Commun 2022 Jul 4;43(7):778-786. Epub 2022 May 4.

Department of Pediatric Oncology.

Purpose: The aim of this study was to evaluate the prognostic value of PET-derived metabolic features and textural parameters of primary tumors in pediatric sarcoma patients.

Methods: The imaging findings of 43 patients (14 girls and 29 boys; age 11.4 ± 4. Read More

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Coupling Lipid Labeling and Click Chemistry Enables Isolation of Extracellular Vesicles for Noninvasive Detection of Oncogenic Gene Alterations.

Adv Sci (Weinh) 2022 05 9;9(14):e2105853. Epub 2022 Mar 9.

California NanoSystems Institute, Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA, 90095, USA.

Well-preserved molecular cargo in circulating extracellular vesicles (EVs) offers an ideal material for detecting oncogenic gene alterations in cancer patients, providing a noninvasive diagnostic solution for detection of disease status and monitoring treatment response. Therefore, technologies that conveniently isolate EVs with sufficient efficiency are desperately needed. Here, a lipid labeling and click chemistry-based EV capture platform ("Click Beads"), which is ideal for EV message ribonucleic acid (mRNA) assays due to its efficient, convenient, and rapid purification of EVs, enabling downstream molecular quantification using reverse transcription digital polymerase chain reaction (RT-dPCR) is described and demonstrated. Read More

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Hypoxia-activated neuropeptide Y/Y5 receptor/RhoA pathway triggers chromosomal instability and bone metastasis in Ewing sarcoma.

Nat Commun 2022 04 28;13(1):2323. Epub 2022 Apr 28.

Department of Biochemistry and Molecular & Cellular Biology, Georgetown University Medical Center, Washington, DC, United States.

Adverse prognosis in Ewing sarcoma (ES) is associated with the presence of metastases, particularly in bone, tumor hypoxia and chromosomal instability (CIN). Yet, a mechanistic link between these factors remains unknown. We demonstrate that in ES, tumor hypoxia selectively exacerbates bone metastasis. Read More

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Tuning levels of low-complexity domain interactions to modulate endogenous oncogenic transcription.

Mol Cell 2022 Jun 27;82(11):2084-2097.e5. Epub 2022 Apr 27.

Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA; Li Ka Shing Center for Biomedical & Health Sciences, University of California, Berkeley, Berkeley, CA 94720, USA; CIRM Center of Excellence, University of California, Berkeley, Berkeley, CA 94720, USA. Electronic address:

Gene activation by mammalian transcription factors (TFs) requires multivalent interactions of their low-complexity domains (LCDs), but how such interactions regulate transcription remains unclear. It has been proposed that extensive LCD-LCD interactions culminating in liquid-liquid phase separation (LLPS) of TFs is the dominant mechanism underlying transactivation. Here, we investigated how tuning the amount and localization of LCD-LCD interactions in vivo affects transcription of endogenous human genes. Read More

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Outcome for Neoadjuvant Treatment of Parotid Gland Adamantinoma-Like Ewing Sarcoma: Case Report and Review of Literatures.

Int J Surg Pathol 2022 Apr 25:10668969221081029. Epub 2022 Apr 25.

Department of Pathology, 378541City of Hope National Medical Center, Duarte, CA, USA.

. Adamantinoma-like Ewing sarcoma typically shows t(11;22) translocation and complex epithelial differentiation. It poses a diagnostic challenge, especially in the head and neck region, due to its under-recognition and significant histologic overlap with other malignancies. Read More

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Rapidly Fatal Ectopic Adrenocorticotropic Hormone Syndrome in a 9-Year-Old Girl With Ewing Sarcoma.

AACE Clin Case Rep 2022 Mar-Apr;8(2):69-72. Epub 2021 Oct 1.

Department of Endocrinology, Andhra Medical College, King George Hospital, Visakhapatnam, Andhra Pradesh, India.

Background: Ewing sarcoma (ES) with ectopic adrenocorticotropic hormone (ACTH) syndrome (ectopic ACTH) is extremely unusual. This report details the first case in English literature of pediatric ES involving the proximal aspect of the humerus with florid ectopic ACTH.

Case Report: A 9-year-old girl presented with mooning of the face and abdominal distension for the past 5 months with an unremarkable history. Read More

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October 2021

Regenerative matching axial vascularisation of absorbable 3D-printed scaffold for large bone defects: A first in human series.

J Plast Reconstr Aesthet Surg 2022 Mar 9. Epub 2022 Mar 9.

Department of Plastic Surgery, Princess Alexandra Hospital, Woolloongabba, QLD, Australia; The Herston Biofabrication Institute, Herston; The University of Queensland, Australia; Southside Clinical Division, School of Medicine, University of Queensland, Woolloongabba, Australia; Department of Plastic and Reconstructive Surgery, Queensland Children's Hospital, South Brisbane, QLD, Australia; The Australian Centre for Complex Integrated Surgical Solutions, Woolloongabba , Australia.

Background: We describe the first clinical series of a novel bone replacement technique based on regenerative matching axial vascularisation (RMAV). This was used in four cases: a tibial defect after treatment of osteomyelitis; a calvarial defect after trauma and failed titanium cranioplasty; a paediatric tibial defect after neoadjuvant chemotherapy and resection of Ewing sarcoma; and a paediatric mandibular deficiency resulting from congenital hemifacial microsomia.

Method: All patients underwent reconstruction with three-dimensional (3D)-printed medical-grade polycaprolactone and tricalcium phosphate (mPCL-TCP) scaffolds wrapped in vascularised free corticoperiosteal flaps. Read More

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The safe surgical margin in Ewing's sarcoma.

Surg Oncol 2022 May 23;41:101737. Epub 2022 Mar 23.

Department of Orthopaedics, Nuffield Orthopaedic Centre, Oxford, UK; Head of Paediatric Sarcoma Service, Oxford, UK.

Introduction: There is recent evidence advocating the use of post-chemotherapy MRI for safe resection of primary bone sarcoma in providing a clear margin of disease. This paper challenges this view by providing evidence obtained from comparing surgical resection margin measurements calculated off the pre- and post-chemotherapy MRIs to the post-operative histological analysis.

Method: A retrospective patho-radiological analysis of 10 patients treated for long bone Ewing's sarcoma. Read More

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Ewing Sarcoma/Primitive Neuroectodermal Tumor Involving the Duodenum.

Ochsner J 2022 ;22(1):94-99

Department of Radiology, Brooke Army Medical Center, Fort Sam Houston, San Antonio, TX.

Ewing sarcoma/primitive neuroectodermal tumor (ES/PNET) is a soft tissue malignancy arising from the neuroectoderm. While the locations of these extraskeletal manifestations are diverse, origin from the small bowel and small bowel mesentery is extremely rare. Intra-abdominal manifestations of ES/PNETs are nonspecific, and patients present with a wide range of symptoms, most frequently vague abdominal pain. Read More

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January 2022

Peripheral primitive neuroectodermal tumor: a case report.

J Med Case Rep 2022 Mar 31;16(1):128. Epub 2022 Mar 31.

Institute of Pathology Anatomy, Faculty of Medicine, University of Prishtina, Prishtina, 10000, Kosovo.

Background: Primitive neuroectodermal tumors are extremely rare and highly aggressive malignant small round cell tumors that arise from the primitive nerve cells of the nervous system or outside it. These tumors share similar histology, immunohistologic characteristics, and cytogenetics with Ewing's sarcoma. Peripheral primitive neuroectodermal tumors of the chest wall are rare malignant tumors seen in children and young adults. Read More

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Primary Adult Renal Ewing's Sarcoma: A Rare Entity.

Cureus 2022 Feb 16;14(2):e22302. Epub 2022 Feb 16.

Department of Pathology, Nazareth Hospital, Shillong, IND.

Ewing's sarcoma/primitive neuroectodermal tumors are high-grade small round blue cell tumors traditionally found in children and adolescents.These tumors primarily affect the bone and soft tissue, with extraskeletal sites rarely being affected. The clinical presentation and imaging findings are non-specific and are not characteristic. Read More

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February 2022

sarcoma arising in the proximal tibia: A case report.

Mol Clin Oncol 2022 Apr 7;16(4):77. Epub 2022 Feb 7.

Department of Orthopedic Surgery, Faculty of Medicine, University of Toyama, Toyama 930-0194, Japan.

BCL6 corepressor-cyclin B3 () fusion sarcoma was classified as an emerging subgroup of undifferentiated small round cell sarcoma in 2020. The incidence of fusion sarcoma is reportedly 1.5-14% among undifferentiated unclassified sarcomas, representing a rare entity among primary malignant bone tumors. Read More

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Multiparametric MRI evaluation of bone sarcomas in children.

Insights Imaging 2022 Mar 1;13(1):33. Epub 2022 Mar 1.

Department of Diagnostic Imaging. Hospital Sant Joan de Déu, Av. Sant Joan de Déu, 2, CP:08950, Esplugues de Llobregat, Barcelona, Spain.

Osteosarcoma and Ewing sarcoma are the most common bone sarcomas in children. Their clinical presentation is very variable depending on the age of the patient and tumor location. MRI is the modality of choice to assess these bone sarcomas and has an important function at diagnosis and also for monitoring recurrence or tumor response. Read More

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Intradural Extramedullary Ewing Sarcoma in an Adolescent Female.

Adolesc Health Med Ther 2022 15;13:39-43. Epub 2022 Feb 15.

Department of Neurosurgery, Aalborg University Hospital, Aalborg, Denmark.

A 15-year-old female experiencing lumbar pain without prior trauma. Despite being prescribed strong analgesics by her family physician, the symptoms intensified, and she was referred to diagnostic imaging. Magnetic resonance imaging revealed an intradural extramedullary tumor in the spinal canal, located behind the L3 corpora. Read More

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February 2022

Subsequent Malignant Neoplasm of Bone in Children and Adolescent-Possibility of Multimodal Treatment.

Curr Oncol 2022 02 11;29(2):1001-1007. Epub 2022 Feb 11.

Departments of Global Pediatric Medicine and Oncology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

Background: In recent years, modifications of treatment protocols introduced in pediatric oncology have resulted in a significant improvement in treatment outcomes. Unfortunately, the probability of subsequent malignant neoplasm (SMN) in this group of patients is 3 to 6 times higher than the general age-matched population. In this study, we sought to evaluate the treatment options for patients with secondary bone tumors after prior anti-cancer therapy. Read More

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February 2022

Ewing's Sarcoma of Rib in a Four Year Old: A Case Report.

JNMA J Nepal Med Assoc 2021 Oct 15;59(242):1052-1055. Epub 2021 Oct 15.

Department of Paediatrics, Kanti Children's Hospital, Maharajgunj, Kathmandu, Nepal.

Although rare, the Ewing's sarcoma family of tumors represents the second most common primary bone malignancy that typically occurs in adolescents and young adults aged 10-25 years, presenting with localized pain and swelling of a long bone. We report a case of Ewing's sarcoma of rib in a four years old child that presented with acute onset of fever, cough, shortness of breath and was initially treated as pneumonia. Although the patient did not belong to typical demography and the symptoms were suggestive of infective pathology, careful scrutiny of the radiographic findings led to further investigations and diagnosis of Ewing's sarcoma of rib after correlating computerized tomography scan findings with immunohistochemistry reports. Read More

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October 2021

Intramedullary, periosteal, and extraskeletal Ewing sarcomas: retrospective study of a series of 126 cases in a reference center.

Skeletal Radiol 2022 Aug 18;51(8):1659-1670. Epub 2022 Feb 18.

Service de Pathologie, Hôpital Cochin, AP‑HP, Paris, France.

Objective: To evaluate the proportion of extraskeletal, periosteal, and intramedullary Ewing sarcomas among musculoskeletal Ewing sarcomas.

Material And Method: Our single-center retrospective study included patients with musculoskeletal Ewing sarcoma diagnosed between 2005 and 2019 in our pathology center (cases from our adult bone tumor referral center and adult and pediatric cases referred for review). Recurrences, metastases, and visceral Ewing sarcomas were excluded. Read More

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