1,719 results match your criteria Ewing Sarcoma Imaging


Sarcomas of the mandible.

J Surg Oncol 2019 Apr 16. Epub 2019 Apr 16.

Department of Surgery, Head and Neck Service, Memorial Sloan Kettering Cancer Center, New York, New York.

Introduction: Sarcomas of the mandible are extremely rare tumors, with osteosarcoma being the most common, followed by Ewing's sarcoma MATERIALS AND METHODS: A retrospective review of the clinical records, imaging studies, and pathology slides of patients with sarcoma of the mandible at a Tertiary Care Cancer Center from 1998 to 2014 was undertaken. The impact of neoadjuvant chemotherapy and postoperative radiotherapy with or without chemotherapy was studied, and factors impacting upon local control and disease-specific survival were analyzed.

Results: Twenty-two patients were treated over the study period, comprising of 15 males and seven females. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jso.25477
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http://dx.doi.org/10.1002/jso.25477DOI Listing
April 2019
1 Read

High-throughput Chemical Screening Identifies Focal Adhesion Kinase and Aurora Kinase B Inhibition as a Synergistic Treatment Combination in Ewing Sarcoma.

Clin Cancer Res 2019 Apr 12. Epub 2019 Apr 12.

Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital

Purpose: Ewing sarcoma is an aggressive solid tumor malignancy of childhood. Although current treatment regimens cure approximately 70% of patients with localized disease, they are ineffective for most patients with metastases or relapse. New treatment combinations are necessary for these patients. Read More

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http://clincancerres.aacrjournals.org/lookup/doi/10.1158/107
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http://dx.doi.org/10.1158/1078-0432.CCR-17-0375DOI Listing
April 2019
3 Reads

Maintenance treatment with trofosfamide in patients with primary bone ewing sarcoma - single center experience.

Dev Period Med 2019 ;23(1):39-44

Departments of Global Pediatric Medicine and Oncology, St. Jude Children's Research Hospital, Memphis, TN, US.

Objective: Background: Patients with Ewing sarcoma have a dismal outcome. Maintenance treatment with trofosfamide has been proposed as an effective regimen for some paediatric malignancies. Aim: We sought to evaluate the schedule of trofosfamide for patients with high-risk primary bone Ewing sarcoma. Read More

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January 2019
1 Read

Skull and Spinal Ewing's Sarcoma in Children: An Institutional Study.

J Pediatr Neurosci 2018 Oct-Dec;13(4):392-397

Department of Pathology, Nizam's Institute of Medical Sciences, Hyderabad, Telangana, India.

Background: Ewing's sarcoma is a disease of children and young adults and occurs most often in bone and soft tissues. The intracranial and spinal manifestation of the disease is rare and reported incidence is 1%-6%.

Aims And Objectives: We conducted this study to determine the surgical outcome of children with skull and spine Ewing's sarcoma (SSES). Read More

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http://dx.doi.org/10.4103/JPN.JPN_109_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413598PMC
April 2019
2 Reads

Preclinical pharmacokinetics and dosimetry studies of [I/I]-CLR1404 for treatment of pediatric solid tumors in murine xenograft models.

J Nucl Med 2019 Mar 29. Epub 2019 Mar 29.

University of Wisconsin-Madison, United States.

Pediatric cancer is the second leading cause of death for children between the ages of 5-14. For children diagnosed with metastatic or recurrent solid tumors, where the utility of external-beam radiotherapy is limited, the prognosis is particularly poor. The availability of tumor-targeting radiopharmaceuticals for molecular radiotherapy (MRT) has demonstrated improved outcomes in these patient populations, but options are nonexistent or limited for most pediatric solid tumors. Read More

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http://jnm.snmjournals.org/lookup/doi/10.2967/jnumed.118.225
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http://dx.doi.org/10.2967/jnumed.118.225409DOI Listing
March 2019
6 Reads

Whole-body MRI vs bone scintigraphy in the staging of Ewing sarcoma of bone: a 12-year single-institution review.

Eur Radiol 2019 Mar 26. Epub 2019 Mar 26.

The Royal National Orthopaedic Hospital, Brockley Hill, Stanmore, HA7 4LP, UK.

Objective: To compare whole-body MRI (WB-MRI) at 1.5/3T and bone scintigraphy in the skeletal staging of Ewing sarcoma (ES) of bone.

Methods: All patients with a histological diagnosis of ES of bone between 2007 and 2018 were retrospectively reviewed. Read More

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http://dx.doi.org/10.1007/s00330-019-06132-9DOI Listing

Imaging of Malignant Primitive Tumors of the Spine.

J Belg Soc Radiol 2018 Sep 6;102(1):56. Epub 2018 Sep 6.

Institut Kassab of Orthopaedics, TN.

Primary malignant tumors of the spine are rare and mainly include chordoma, chondrosarcoma, Ewing sarcoma or primitive neuroectodermal tumor, and osteosarcoma. The final diagnosis is based on the combination of patient age, topographic and histologic features of the tumor, and lesion pattern on computed tomography (CT) and magnetic resonance (MR) imaging. Imaging evaluation includes radiography, CT, bone scintigraphy, and MR imaging. Read More

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http://dx.doi.org/10.5334/jbsr.1410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425224PMC
September 2018
1 Read

Gastrointestinal: Multi-modality imaging of extraskeletal Ewing sarcoma of the stomach.

Authors:
A C Hopp B D Nguyen

J Gastroenterol Hepatol 2019 Mar 25. Epub 2019 Mar 25.

Department of Radiology, Mayo Clinic Arizona, Scottsdale, Arizona, USA.

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http://dx.doi.org/10.1111/jgh.14638DOI Listing

EZH2 Inhibition in Ewing Sarcoma Upregulates G Expression for Targeting with Gene-Modified T Cells.

Mol Ther 2019 Feb 23. Epub 2019 Feb 23.

Department of Pediatric Hematology and Oncology, University Children's Hospital Münster, 48149 Münster, Germany; Cells-in-Motion Cluster of Excellence (EXC 1003 - CiM), University of Münster, 48149 Münster, Germany. Electronic address:

Chimeric antigen receptor (CAR) engineering of T cells allows one to specifically target tumor cells via cell surface antigens. A candidate target in Ewing sarcoma is the ganglioside G, but heterogeneic expression limits its value. Here we report that pharmacological inhibition of Enhancer of Zeste Homolog 2 (EZH2) at doses reducing H3K27 trimethylation, but not cell viability, selectively and reversibly induces G surface expression in Ewing sarcoma cells. Read More

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http://dx.doi.org/10.1016/j.ymthe.2019.02.014DOI Listing
February 2019

The relation of radiological tumor volume response to histological response and outcome in patients with localized Ewing Sarcoma.

Cancer Med 2019 Mar 21;8(3):1086-1094. Epub 2019 Feb 21.

Emma Children's Hospital, Department of Pediatric Oncology, Academic Medical Center, Amsterdam, The Netherlands.

Background: Magnetic resonance imaging (MRI) is the modality of choice for local staging and response evaluation of Ewing sarcoma (EwS). Aim of this study was to determine the relevance of tumor volume response (TVR) in relation to histological response (HisRes) and survival, in order to evaluate if early modification of chemotherapy might be indicated in patients with inadequate TVR.

Methods: Three dimensional (3D)-tumor volume data at diagnosis, during early induction phase (1-3 courses of chemotherapy; n = 195) and/or late induction phase (4-6 courses; n = 175) from 241 localized patients were retrospectively analyzed. Read More

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http://dx.doi.org/10.1002/cam4.2002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434194PMC

Role of fluoroethyl tyrosine positron emission tomography-computed tomography scan in differentiating ewing's sarcoma from osteomyelitis.

World J Nucl Med 2019 Jan-Mar;18(1):77-80

Department of Nuclear Medicine and PET Imaging, Institute of Nuclear Medicine and Allied Sciences, New Delhi, India.

Ewing's sarcoma is a kind of undifferentiated reticulocytic sarcoma, which was first reported in 1921 by James Ewing. It is difficult to differentiate Ewing's sarcoma from osteomyelitis on computed tomography (CT) and X-ray and hence cytological confirmation is needed. Fluorodeoxy glucose being a nonspecific tracer cannot differentiate between malignant and inflammatory lesions. Read More

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http://dx.doi.org/10.4103/wjnm.WJNM_23_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357705PMC
February 2019

Rare Case of Sellar and Suprasellar Metastasis from Ewing's Sarcoma of Tibia.

J Neurosci Rural Pract 2019 Jan-Mar;10(1):158-161

Department of Neurosurgery, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.

We hereby report a case of metastatic Ewing's sarcoma presenting with rapid-onset total ophthalmoplegia, optic atrophy, and right temporal hemianopia. Comprehensive ophthalmic and neurological evaluation with targeted radioimaging revealed a tumor mass centered over the sella, compressing optic chiasma, extending to involve the left cavernous sinus and the left orbital apex. Whole-body imaging revealed the evidence of multifocal lung and mediastinal metastasis with focal lytic defect in the left femoral head. Read More

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http://dx.doi.org/10.4103/jnrp.jnrp_139_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338001PMC
February 2019
1 Read

Bone marrow biopsy in the initial staging of Ewing sarcoma: Experience from a single institution.

Pediatr Blood Cancer 2019 Jun 5;66(6):e27653. Epub 2019 Feb 5.

Chemotherapy Section, IRCCS-Rizzoli Orthopaedic Institute, Bologna, Italy.

Background: Ewing sarcoma (ES) is the second most common bone tumor in adolescents and children. Staging workup for ES includes imaging and bone marrow biopsy (BMB). The effective role of BMB is now under discussion. Read More

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http://dx.doi.org/10.1002/pbc.27653DOI Listing
June 2019
1 Read
2.562 Impact Factor

Trabectedin Inhibits EWS-FLI1 and Evicts SWI/SNF from Chromatin in a Schedule-dependent Manner.

Clin Cancer Res 2019 Feb 5. Epub 2019 Feb 5.

Van Andel Research Institute, Grand Rapids, Michigan.

The successful clinical translation of compounds that target specific oncogenic transcription factors will require an understanding of the mechanism of target suppression to optimize the dose and schedule of administration. We have previously shown trabectedin reverses the gene signature of the EWS-FLI1 transcription factor. In this report, we establish the mechanism of suppression and use it to justify the reevaluation of this drug in the clinic in patients with Ewing sarcoma. Read More

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http://dx.doi.org/10.1158/1078-0432.CCR-18-3511DOI Listing
February 2019
2 Reads

Ewing's Sarcoma and Primary Osseous Lymphoma: Spectrum of Imaging Appearances.

Semin Musculoskelet Radiol 2019 Feb 30;23(1):36-57. Epub 2019 Jan 30.

Department of Radiology, AZ Sint-Maarten Mechelen, University Hospital Antwerp, Ghent University, Mechelen, Belgium.

Ewing's sarcoma (ES) is a rare, highly malignant anaplastic stem cell tumor. Histologically, the tumor consists of uniform densely packed small monomorphic cells with round nuclei. The typical appearance at hematoxylin and eosin (H&E) staining is small blue round cells without any matrix formation. Read More

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http://dx.doi.org/10.1055/s-0038-1676125DOI Listing
February 2019
6 Reads

Isolated delayed metastasis to the talus from Ewing's sarcoma.

J Radiol Case Rep 2018 Aug 31;12(8):17-24. Epub 2018 Aug 31.

Department Of Radiology, American University Of Beirut Medical Center, Beirut, Lebanon.

Bone metastasis to the hands and feet, known as acrometastasis, is a very rare finding and tends to be associated with extensive metastasis. We herein report the case of a 14-year-old girl known to have a history of successfully treated Ewing's sarcoma arising from the ribs, who presented with a pathologically proven isolated metastatic lesion to the talus 7 years after achieving clinical and radiologic remission. We describe the imaging findings on MRI, CT scan and PET-CT. Read More

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http://dx.doi.org/10.3941/jrcr.v12i8.3164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312123PMC
August 2018
10 Reads

Primary Intra-abdominal Ewing's Sarcoma in Adults: A Multimodality Imaging Spectrum.

Curr Probl Diagn Radiol 2019 Jan 2. Epub 2019 Jan 2.

Department of Radiology, UW Medicine, Seattle, WA. Electronic address:

Ewing sarcoma (ES) and peripheral primitive neuroectodermal tumor are part of a spectrum of neoplastic diseases known as the ES family of tumors, which also includes extraosseous ES, peripheral primitive neuroectodermal tumor, malignant small-cell tumor of the thoracopulmonary region (Askin's tumor), and atypical ES. Although imaging features of these tumors have been previously described, extensive discussion about intra-abdominal manifestations is scarce in the literature. We present an imaging spectrum of these tumors in the abdomen and pelvis with particular attention to multimodality approach for staging and restaging. Read More

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http://dx.doi.org/10.1067/j.cpradiol.2018.12.009DOI Listing
January 2019
2 Reads

Primary Ewing sarcoma of the squamous temporal bone with intracranial and extracranial extension: A rare cause of sudden sensorineural hearing loss.

Head Neck 2019 Mar 24;41(3):E38-E41. Epub 2018 Dec 24.

Department of Pediatrics and Biomedical Research Institute, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea.

Background: Primary Ewing sarcoma of the cranial bone is rare, accounting for only 1% of all Ewing sarcomas. Primary Ewing sarcoma arising in the squamous temporal bone is particularly rare.

Methods: A 16-year-old male was seen with signs of sudden sensorineural hearing loss (SSNHL). Read More

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http://dx.doi.org/10.1002/hed.25449DOI Listing

Intraneural Ewing Sarcoma of Fibular Nerve: Case Report, Radiologic Findings and Review of Literature.

World Neurosurg 2019 Mar 20;123:212-215. Epub 2018 Dec 20.

Neurosurgery Unit, Department of Neurosciences, University of Turin, Turin, Italy.

Background: Intraneural Ewing sarcoma (ES) was first described in 1918 by Stout in a tumor of the ulnar nerve. These tumors are in the category of ES family of tumors, together with ES of bone, extraosseous ES, and primitive neuroectodermal tumor. ES typically occurs in the second decade of life; only 20% of cases affect elder people. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.12.043DOI Listing
March 2019
8 Reads

Atypical localization of intraosseous angioleiomyoma in the rib of a pediatric patient: a case report.

BMC Med Imaging 2018 12 19;18(1):54. Epub 2018 Dec 19.

Institute of Pathology, School of Medicine, University of Belgrade, Dr Subotica 1, 11000, Belgrade, Republic of Serbia.

Background: This is the first reported case of a primary intraosseous angioleiomyoma and the second case of a primary leiomyoma of the rib, irrespective of age. Angioleiomyomas mostly occur in patients of advanced age, in any part of the body, particularly the lower extremities and present as painful, slow-growing nodules in the dermis, subcutaneous fat or deep fascia. Other localizations, especially bone, are considered extremely rare, as well as their occurrence in paediatric patients. Read More

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http://dx.doi.org/10.1186/s12880-018-0297-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300016PMC
December 2018
6 Reads

Broad Spectrum Activity of the Checkpoint Kinase 1 Inhibitor Prexasertib as a Single Agent or Chemopotentiator Across a Range of Preclinical Pediatric Tumor Models.

Clin Cancer Res 2019 Apr 18;25(7):2278-2289. Epub 2018 Dec 18.

Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana.

Purpose: Checkpoint kinase 1 (CHK1) inhibitors potentiate the DNA-damaging effects of cytotoxic therapies and/or promote elevated levels of replication stress, leading to tumor cell death. Prexasertib (LY2606368) is a CHK1 small-molecule inhibitor under clinical evaluation in multiple adult and pediatric cancers. In this study, prexasertib was tested in a large panel of preclinical models of pediatric solid malignancies alone or in combination with chemotherapy. Read More

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http://dx.doi.org/10.1158/1078-0432.CCR-18-2728DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445779PMC
April 2019
10 Reads

Lower Extremity Weakness in an Adolescent Female - A Rare Presentation of Ewing Sarcoma.

Ochsner J 2018 ;18(4):402-405

Department of Internal Medicine, Aurora Health Care, Milwaukee, WI.

Background: Ewing sarcoma, a rare cause of cord compression, is predominantly of osseous origin but can also originate in soft tissues. Soft-tissue manifestations account for <15% of all Ewing sarcoma tumors, and even fewer cases of Ewing sarcoma originating in the epidural space have been documented.

Case Report: A 19-year-old female presented to the emergency department for worsening low-back pain during the previous 6 months and numbness and weakness in her legs during the prior 2 weeks. Read More

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http://dx.doi.org/10.31486/toj.18.0039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292469PMC
January 2018

A Pitfall for Diffusion-weighted MR Imaging When Assessing the Response to Neoadjuvant Chemotherapy in Ewing Sarcoma.

Magn Reson Med Sci 2018 Dec 6. Epub 2018 Dec 6.

Department of Radiology, Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen.

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https://www.jstage.jst.go.jp/article/mrms/advpub/0/advpub_ci
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http://dx.doi.org/10.2463/mrms.ci.2018-0122DOI Listing
December 2018
10 Reads

Effectiveness of 18F-FDG PET/CT in the diagnosis, staging and recurrence monitoring of Ewing sarcoma family of tumors: A meta-analysis of 23 studies.

Medicine (Baltimore) 2018 Nov;97(48):e13457

Department of Orthopaedics, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, China.

Background: To investigate the value of positron emission tomography (PET) and PET/computed tomography (CT) using fluorine-18-fluorodeoxyglucose (F-FDG) in the diagnosis, staging, restaging and recurrence monitoring of Ewing sarcoma family of tumors (ESFTs), a meta-analysis was performed through systematically searching PubMed, Embase, and Cochrane Central library to retrieve articles.

Methods: After screening and diluting out the articles that met inclusion criteria to be used for statistical analysis the pooled evaluation indexes including sensitivity, specificity, and diagnostic odd ratio (DOR) as well as the summary receiver operating characteristic curve (SROC) were calculated involving diagnostic data (true positive, false positive, false negative, and true negative) extracted from original studies.

Results: Screening determined that out of 2007, 23 studies involving a total of 524 patients were deemed viable for inclusion in the meta-analysis. Read More

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http://dx.doi.org/10.1097/MD.0000000000013457DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283220PMC
November 2018
2 Reads
5.723 Impact Factor

Clinical Features and Long-Term Outcome of Primary Intracranial Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumors: 14 Cases From a Single Institution.

World Neurosurg 2019 Feb 26;122:e1606-e1614. Epub 2018 Nov 26.

Department of Neurosurgery, Tongji Hospital, Tongji Medical School, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China. Electronic address:

Objective: Primary intracranial Ewing sarcoma (ES)/peripheral primitive neuroectodermal tumors (pPNETs) are extremely rare, and only a few studies have reported >4 cases of this disease. The purpose of this study was to explore the clinical features, treatment, and outcome of primary intracranial ES/pPNETs.

Methods: The clinical data of 14 patients who had been surgically treated from February 2003 to November 2017 and in whom immunohistochemical staining results had confirmed the diagnosis of primary intracranial ES/pPNETs were retrospectively analyzed. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.11.151DOI Listing
February 2019
2 Reads

Ewing's sarcoma of kidney in a 60-year-old patient with local recurrence: A rare occurrence.

J Cancer Res Ther 2018 Oct-Dec;14(6):1422-1424

Department of Medical Oncology, Gazi University Faculty of Medicine, Ankara, Turkey.

Ewing's family of tumors is aggressive tumors and frequently arises from bone and soft tissue. They might also arise from nonosseous structures such as gastrointestinal tract, adrenal glands, or kidney. Primary renal Ewing's sarcoma (ES)/primitive neuroectodermal tumor is an extremely rare entity which has aggressive clinical course. Read More

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http://dx.doi.org/10.4103/0973-1482.191062DOI Listing
February 2019
2 Reads

Early recognition and diagnosis of Ewing sarcoma of the cervical spine.

Radiol Case Rep 2019 Feb 2;14(2):160-163. Epub 2018 Nov 2.

Department of Radiology, SUNY Upstate University Hospital, 750 East Adams Street, Syracuse, NY 13210, USA.

Ewing sarcoma of the cervical spine is a rare diagnosis. Early recognition and treatment of this condition improves survival. Reported is a case of a 20-year-old male patient who presented with increasing neck pain. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S19300433183035
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http://dx.doi.org/10.1016/j.radcr.2018.09.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223226PMC
February 2019
8 Reads

Compressive optic neuropathy secondary to Ewing sarcoma in the paranasal sinus: A case report.

Medicine (Baltimore) 2018 Nov;97(44):e13027

Department of Ophthalmology.

Rationale: Ewing sarcoma localized in the paranasal sinuses, compressing the optic nerve, is very rare, with no prior case reports PATIENT CONCERNS:: A 68-year-old woman presented with decreased visual acuity in her left eye and paresthesia of the left face. Brain magnetic resonance imaging showed heterogeneously enhancing mass in the left paranasal sinuses with adjacent bone destruction, extending to the extraocular muscles and optic nerve of the left orbit. A biopsy of the nasal cavity confirmed Ewing sarcoma. Read More

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http://dx.doi.org/10.1097/MD.0000000000013027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221559PMC
November 2018
6 Reads

Scrotal Peripheral Primitive Neuroectodermal Tumor.

Curr Urol 2018 Oct 30;12(1):50-53. Epub 2018 Jun 30.

Radiology Department, Hospital Policlínico La Rosaleda C/Santiago León de Caracas, Santiago de Compostela, Spain.

The peripheral primitive neuroectodermal tumor (pPNET) is a rare malignant tumor originating from neuroectoderm that usually occurs in children or adolescent and is frequently located in the extremities, chest cavity, pelvic cavity and chest wall. We present a rare case of an 84-year-old man with a history of pPNET in the scrotal sac, to our knowledge not previously published in the literature. The presence of a large irreducible mass in the inguinal sac forced to exclude a tumor. Read More

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https://www.karger.com/Article/FullText/447231
Publisher Site
http://dx.doi.org/10.1159/000447231DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198772PMC
October 2018
1 Read

The usefulness of wide excision assisted by a computer navigation system and reconstruction using a frozen bone autograft for malignant acetabular bone tumors: a report of two cases.

BMC Cancer 2018 Oct 24;18(1):1036. Epub 2018 Oct 24.

Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kanazawa University, 13-1 Takara-machi, Kanazawa, 920-8641, Japan.

Background: Difficult resection of tumors from regions with complex local anatomy, such as the pelvis and sacrum, is likely to result in inadequate surgical margins (intralesional or marginal); this is because three-dimensional osteotomy is difficult particularly around the acetabulum. Additionally, removal of the joint makes reconstruction very difficult; thus, retention of good function also becomes difficult. In musculoskeletal oncology, computer navigation systems are still not widely used to prevent tumor-positive margins. Read More

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http://dx.doi.org/10.1186/s12885-018-4971-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201638PMC
October 2018
3 Reads

Ewing Sarcoma in an Infant Metacarpal.

J Hand Surg Am 2018 Oct 17. Epub 2018 Oct 17.

Department of Orthopedic Surgery and Rehabilitation, University of Oklahoma Health Sciences Center, Oklahoma City, OK. Electronic address:

We describe a case of Ewing sarcoma in the metacarpal of a 5-month-old male. After pain, erythema, and swelling of the hand failed to resolve with antibiotics, radiographs and magnetic resonance imaging raised suspicion for a neoplastic condition. Open biopsy confirmed the diagnosis of Ewing sarcoma and treatment with chemotherapy and surgical resection was initiated. Read More

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http://dx.doi.org/10.1016/j.jhsa.2018.09.001DOI Listing
October 2018

Establishment of a novel patient-derived Ewing's sarcoma cell line, NCC-ES1-C1.

In Vitro Cell Dev Biol Anim 2018 Dec 15;54(10):770-778. Epub 2018 Oct 15.

Department of Innovative Seeds Evaluation, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.

Ewing's sarcoma is an aggressive mesenchymal tumor characterized by the presence of a unique EWSR1-FLI1 translocation. Ewing's sarcoma primarily occurs in the bone and soft tissues. Cell lines enable researchers to investigate the molecular backgrounds of disease and the significance of genetic alterations in relevant cellular contexts. Read More

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http://dx.doi.org/10.1007/s11626-018-0302-2DOI Listing
December 2018
16 Reads

Ewing's Sarcoma/Peripheral Primitive Neuroectodermal Tumors in Bronchus.

Am J Med Sci 2019 Jan 22;357(1):75-80. Epub 2018 Aug 22.

Department of Medical imaging, The Second Hospital of Hebei Medical University, Shijiazhuang, China. Electronic address:

Ewing sarcoma/peripheral primitive neuroectodermal tumors (ES/pPNET), a member of the Ewing sarcoma family of tumors, is a malignant soft tissue tumor with small undifferentiated neuroectodermal cells. Primary trachea-bronchial ES/pPNET is very rare. The most common pulmonary ES is due to a metastasis. Read More

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http://dx.doi.org/10.1016/j.amjms.2018.08.009DOI Listing
January 2019
11 Reads

An Uncommon Presentation of a Primary Bone Tumor: Anti-AMPA (Anti-α-Amino-3-Hydroxy-5-Methyl-4-Isoxazolepropionic acid) Receptor Limbic/Paraneoplastic Encephalitis as a Presenting Feature of Ewing Sarcoma.

J Pediatr Hematol Oncol 2018 Oct;40(7):555-557

Department of Diagnostic Imaging, Monash Health.

Anti-AMPA (anti-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptor limbic encephalitis is a rare autoimmune syndrome. It can be associated with an underlying malignancy, such as lung, breast, or thymus. We are reporting a case of a 19-year-old patient who presented with a 2-week history of confusion and short-term memory loss. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001304DOI Listing
October 2018
2 Reads

Posterior Reversible Encephalopathy Syndrome in Pediatric Cancer: Clinical and Radiologic Findings.

J Glob Oncol 2018 Sep 4;4:1-8. Epub 2017 Dec 4.

All authors: Shaukat Khanum Cancer Hospital and Research Center, Lahore, Pakistan.

Purpose: Posterior reversible encephalopathy syndrome (PRES) is associated with a range of medical conditions and medications. In this retrospective analysis, we present 19 pediatric patients with PRES who had undergone chemotherapy.

Methods: We identified four female and 15 male patients diagnosed with PRES on the basis of clinical and radiologic features. Read More

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http://dx.doi.org/10.1200/JGO.17.00089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181184PMC
September 2018
4 Reads

Applications of PET/CT and PET/MR Imaging in Primary Bone Malignancies.

PET Clin 2018 Oct 17;13(4):623-634. Epub 2018 Aug 17.

Division of Nuclear Medicine, Department of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90007, USA.

Primary bone malignancies are characterized with anatomic imaging. However, in recent years, there has been an increased interest in PET/computed tomography scanning and PET/MRI with fludeoxyglucose F 18 for evaluating and staging musculoskeletal neoplasms. These hybrid imaging modalities have shown promise largely owing to their high sensitivity, ability to perform more thorough staging, and ability to monitor treatment response. Read More

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http://dx.doi.org/10.1016/j.cpet.2018.05.012DOI Listing
October 2018
20 Reads

Introducing fluorescence guided surgery into orthopedic oncology: A systematic review of candidate protein targets for Ewing sarcoma.

J Surg Oncol 2018 Nov 13;118(6):906-914. Epub 2018 Sep 13.

Department of Surgery, Leiden University Medical Center, The Netherlands.

Ewing sarcoma (ES), an aggressive bone and soft-tissue tumor, is treated with chemotherapy, radiotherapy, and surgery. Intra-operative distinction between healthy and tumorous tissue is of paramount importance but challenging, especially after chemotherapy and at complex anatomical locations. Near infrared (NIR) fluorescence-guided surgery (FGS) is able to facilitate the determination of tumor boundaries intra-operatively, improving complete resection and therefore survival. Read More

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http://dx.doi.org/10.1002/jso.25224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220824PMC
November 2018
1 Read

Imaging features of Ewing's sarcoma: Special reference to uncommon features and rare sites of presentation.

J Cancer Res Ther 2018 Jul-Sep;14(5):1014-1022

Department of Radiology, Nizam's Institute of Medical Sciences, Hyderabad, Telangana, India.

Context: Ewing's sarcoma (EWS) commonly involves long bones with a permeative pattern of bone destruction and aggressive interrupted periosteal new bone formation. However, radiological features show wide variation and some presentations are uncommon, leading to diagnostic confusion. This study is aimed at studying the imaging features of proven EWS and highlight the uncommon features and rare sites of presentation. Read More

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http://dx.doi.org/10.4103/jcrt.JCRT_1350_16DOI Listing
November 2018
2 Reads

Extraosseous Ewing sarcoma arising in a chronically lymphedematous limb.

J Vasc Surg Cases Innov Tech 2018 Sep 17;4(3):210-215. Epub 2018 Aug 17.

Department of Anatomical Pathology, Royal Hobart Hospital, Tasmania, Australia.

Ewing sarcoma is a highly aggressive small round cell malignant neoplasm of bone and soft tissue that typically is manifested in children and young adults. It is most commonly a primary bone tumor; however, extraosseous cases have been increasingly reported. We report a case of metastatic extraosseous Ewing sarcoma with the primary lesion occurring within a limb affected by primary lymphedema. Read More

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http://dx.doi.org/10.1016/j.jvscit.2018.04.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6105752PMC
September 2018
2 Reads

Analysis of bone and soft-tissue sarcomas registered during the year 2012 at Tata Memorial Hospital, Mumbai, with clinical outcomes.

Indian J Cancer 2018 Jan-Mar;55(1):37-44

Department of Surgical Pathology, Bone and Soft Tissues, Disease Management Group (DMG), Tata Memorial Hospital, Mumbai, Maharashtra, India.

Introduction: Primary bone and soft tissue sarcomas are rare, but diagnostically and therapeutically challenging group of tumors, requiring multidisciplinary management. There are limited documented studies from multidisciplinary teams , in the form of comprehensive analysis of these tumors, from our country. This study is an analysis of cases of osteosarcomas, Ewing sarcomas (ESs), chondrosarcomas (CSs), and soft-tissue sarcomas (STSs), registered at our institution during 2012. Read More

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http://dx.doi.org/10.4103/ijc.IJC_481_17DOI Listing
November 2018
10 Reads

Diagnostic Immunohistochemistry for Soft Tissue and Bone Tumors: An Update.

Adv Anat Pathol 2018 Nov;25(6):400-412

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

Although some soft tissue and bone tumors can be identified based on histologic features alone, immunohistochemistry plays a critical diagnostic role for most mesenchymal tumor types. The discovery of recurrent genomic alterations in many benign and malignant mesenchymal neoplasms has added important biologic insights and expanded the spectrum of some diagnostic subgroups. Some tumors are defined by unique genomic alterations, whereas others share abnormalities that are not tumor-specific and can be observed in a sometimes broad range of biologically unrelated neoplasms. Read More

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http://dx.doi.org/10.1097/PAP.0000000000000204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442933PMC
November 2018
19 Reads

Abemaciclib Is Active in Preclinical Models of Ewing Sarcoma via Multipronged Regulation of Cell Cycle, DNA Methylation, and Interferon Pathway Signaling.

Clin Cancer Res 2018 Dec 21;24(23):6028-6039. Epub 2018 Aug 21.

Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana.

Purpose: Ewing sarcoma (ES) is a rare and highly malignant cancer that occurs in the bone and surrounding tissue of children and adolescents. The fusion transcription factor that drives ES pathobiology was previously demonstrated to modulate cyclin D1 expression. In this study, we evaluated abemaciclib, a small-molecule CDK4 and CDK6 (CDK4 and 6) inhibitor currently under clinical investigation in pediatric solid tumors, in preclinical models of ES. Read More

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http://clincancerres.aacrjournals.org/lookup/doi/10.1158/107
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http://dx.doi.org/10.1158/1078-0432.CCR-18-1256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279561PMC
December 2018
22 Reads

Sorafenib in patients with progressed and refractory bone tumors.

Med Oncol 2018 Aug 16;35(10):126. Epub 2018 Aug 16.

Department of Oncology and Surgical Oncology for Children and Youth, Institute of Mother and Child, 01-211 Warszawa, ul. Kasprzaka 17a, Warsaw, Poland.

Patients with metastatic, progressive, or recurrent bone tumors have a dismal outcome. Sorafenib has been proposed as an effective salvage regimen for some malignancies. Thus, we sought to evaluate this approach for young patients with relapsed or refractory bone tumors. Read More

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http://dx.doi.org/10.1007/s12032-018-1180-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097021PMC
August 2018
7 Reads

Retrospective audit of 957 consecutive F-FDG PET-CT scans compared to CT and MRI in 493 patients with different histological subtypes of bone and soft tissue sarcoma.

Clin Sarcoma Res 2018 9;8. Epub 2018 Apr 9.

1Oxford Sarcoma Service (OxSarc), Oxford University Hospitals Foundation Trust, Oxford, OX3 7LE UK.

Background: The use of F-FDG PET-CT (PET-CT) is widespread in many cancer types compared to sarcoma. We report a large retrospective audit of PET-CT in bone and soft tissue sarcoma with varied grade in a single multi-disciplinary centre. We also sought to answer three questions. Read More

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http://dx.doi.org/10.1186/s13569-018-0095-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086048PMC
April 2018
3 Reads

Staging and following common pediatric malignancies: MRI versus CT versus functional imaging.

Authors:
Stephan D Voss

Pediatr Radiol 2018 08 4;48(9):1324-1336. Epub 2018 Aug 4.

Department of Radiology, Boston Children's Hospital, Harvard Medical School, 300 Longwood Ave., Boston, MA, 02115, USA.

Most pediatric malignancies require some form of cross-sectional imaging, either for staging or response assessment. The majority of these are solid tumors and this review addresses the role of MRI, as well as other cross-sectional and functional imaging techniques, for evaluating the most common pediatric solid tumors. The primary emphasis is on neuroblastoma, hepatoblastoma and Wilms tumor, three of the most common non-central-nervous-system (CNS) pediatric solid tumors encountered in young children. Read More

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http://dx.doi.org/10.1007/s00247-018-4162-4DOI Listing
August 2018
8 Reads

Ewing Sarcoma of the Femur.

J Orthop Sports Phys Ther 2018 Jul;48(7):594

A 26-year-old active woman with knee pain was seen by her primary care physician and diagnosed with patellofemoral pain (PFP). Radiographs of the knee were interpreted as noncontributory. Her knee symptoms continued, and 8 weeks later she was referred to a physiatrist, who confirmed the PFP diagnosis and referred her to physical therapy. Read More

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http://dx.doi.org/10.2519/jospt.2018.7835DOI Listing
July 2018
16 Reads

Myoepithelioma occurring in the posterior mediastinum harboring EWSR1 rearrangement: a case report.

Jpn J Clin Oncol 2018 Sep;48(9):851-854

Department of General Thoracic, Breast and Endocrinological Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.

Myoepithelioma is a rare neoplasm usually occurring in the salivary glands or the mammary glands but also, more rarely, in the thoracic cavity. The diagnosis of myoepithelioma is based on the presence of histological and immunohistochemical characteristics of myoepithelioma, but in unusual locations, the diagnosis is challenging. For such cases, cytogenetic approaches have been developed as helpful tools for the diagnosis. Read More

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http://dx.doi.org/10.1093/jjco/hyy100DOI Listing
September 2018
2 Reads

Reconstructing diaphyseal tumors using radiated (50 Gy) autogenous tumor bone graft.

J Surg Oncol 2018 Jul 27;118(1):138-143. Epub 2018 Jun 27.

Department of Radiation Oncology, Tata Memorial Hospital, HBNI, Mumbai, India.

Aims: Establish oncologic safety using 50 Gy to sterilize tumor bearing bone before reimplantation in primary diaphyseal high grade extremity tumors, determine extracorporeal radiotherapy (ECRT) graft survival, and analyze factors that affect union at osteotomy sites.

Materials And Methods: Seventy non metastatic patients underwent reconstruction with intercalary ECRT grafts sterilized with 50 Gy. Diagnosis included osteosarcoma (38) and Ewing's sarcoma (32). Read More

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http://doi.wiley.com/10.1002/jso.25092
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http://dx.doi.org/10.1002/jso.25092DOI Listing
July 2018
26 Reads

KDM3A is not associated with metastasis and prognosis of breast cancer.

Oncol Lett 2018 Jun 25;15(6):9751-9756. Epub 2018 Apr 25.

The Imaging Center, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang Uyghur Autonomous Region 830054, P.R. China.

Lysine demethylase 3A (KDM3A), also known as JMJD1A, has been associated with metastasis and poor prognosis in several cancer types, including renal cell carcinoma, prostate cancer and Ewing sarcoma. However, little is known regarding the clinicopathological significance of KDM3A expression in breast cancer (BCa). To investigate the clinical relevance of KDM3A expression in the setting of BCa, immunohistochemistry was performed on a tissue microarray consisting of 150 commercially available BCa samples. Read More

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http://dx.doi.org/10.3892/ol.2018.8578DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6004682PMC
June 2018
1 Read
0.990 Impact Factor