7,327 results match your criteria Evidence-based Complementary and Alternative Medicine [Journal]


Effective Treatment of Bovine Mastitis with Intramammary Infusion of and Extracts.

Evid Based Complement Alternat Med 2019 3;2019:7242705. Epub 2019 Mar 3.

Institute of Medical Sciences, Tzu Chi University, Hualien 97004, Taiwan.

Mastitis in dairy cattle is a highly prevalent infectious disease, causing considerable economic loss worldwide. In this study, we used and extracts (designated as Yi-Xiong-Tang, YXT) for mastitis treatment. California mastitis test (CMT) was performed and 67 mastitis udder quarters were identified among 179 lactating dairy cows. Read More

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http://dx.doi.org/10.1155/2019/7242705DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451796PMC

Tian Wang Bu Xin Dan for Insomnia: A Systematic Review of Efficacy and Safety.

Evid Based Complement Alternat Med 2019 24;2019:4260801. Epub 2019 Mar 24.

The TCM Clinical Institute, Hubei University of Chinese Medicine, Hubei 430065, China.

Background: The Traditional Chinese Medicine (TCM) Tian Wang Bu Xin Dan (TWBXD) has been used widely for treating insomnia in China. The purpose of this meta-analysis was to evaluate the efficacy and safety of TWBXD in the treatment of insomnia.

Objective: This study evaluated the efficacy and safety of TWBXD for insomnia. Read More

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http://dx.doi.org/10.1155/2019/4260801DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451824PMC

Compound L Inhibits HBV-Related HCC through HBx-SHH Pathway Axis Inactivation.

Evid Based Complement Alternat Med 2019 24;2019:1635837. Epub 2019 Mar 24.

Shenzhen Traditional Chinese Medicine Hospital, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, China.

(CP) is a traditional formula widely used in clinical practice for hepatocellular carcinoma (HCC), especially HBV-related HCC. HBx, HBV X gene encoded X protein, has positive correlation with the abnormal SHH pathway in HBV-related HCC. So, we predicted that CP has the capability of anti-HBV-related HCC maybe via inactivating the HBx-Hedgehog pathway axis. Read More

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http://dx.doi.org/10.1155/2019/1635837DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451826PMC

Pharmacokinetic and Bioavailability Studies of Embelin after Intravenous and Oral Administration to Rats.

Evid Based Complement Alternat Med 2019 20;2019:9682495. Epub 2019 Mar 20.

Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 300193, China.

Embelin exhibits the broad bioactivities such as antitumor, antifertility, antidiabetic, anti-inflammatory, antioxidant, anticonvulsant, anxiolytic, antimicrobial, and hepatoprotective activity. In order to further understand the pharmacokinetic characteristics and oral bioavailability of embelin , the concentration of embelin in rat plasma was determined by a sensitive high-performance liquid chromatography with diode array detector (HPLC-DAD). The preparation of samples was accomplished by a simple precipitating protein with methanol. Read More

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https://www.hindawi.com/journals/ecam/2019/9682495/
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http://dx.doi.org/10.1155/2019/9682495DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446108PMC
March 2019
1 Read

Acupuncture Points and Perforating Cutaneous Vessels Identified Using Infrared Thermography: A Cross-Sectional Pilot Study.

Evid Based Complement Alternat Med 2019 21;2019:7126439. Epub 2019 Mar 21.

Department of Physical Therapy, Regional Campus of International Excellence "Campus Mare Nostrum", University of Murcia, Murcia, Spain.

Aims: To evaluate the presence of perforating cutaneous vessels (PCV) in different lower limb acupuncture points (AP) using thermography.

Material And Methods: An analytical cross-sectional study was performed on the two lower limbs (n=6) of volunteer subjects. In total, 144 AP and 144 control points (CP) were analysed, one for each AP. Read More

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http://dx.doi.org/10.1155/2019/7126439DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448333PMC

Anatomical Evidence of Acupuncture Meridians in the Human Extracellular Matrix: Results from a Macroscopic and Microscopic Interdisciplinary Multicentre Study on Human Corpses.

Evid Based Complement Alternat Med 2019 21;2019:6976892. Epub 2019 Mar 21.

Center for Anatomy and Cell Biology, Division of Anatomy, Medical University of Vienna, Währinger Straße 13, 1090 Wien, Austria.

For more than 2500 years, acupuncture has been applied to support the healing of different diseases and physiologic malfunctions. Although various theories of the meridian system and mechanisms were formulated to explain the functional basis of acupuncture, the anatomical basis for the concept of meridians has not been resolved. The aim of the present study was to search for replicable anatomical structures that could relate to meridians. Read More

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http://dx.doi.org/10.1155/2019/6976892DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448339PMC

Comparisons of the Effectiveness and Safety of Tuina, Acupuncture, Traction, and Chinese Herbs for Lumbar Disc Herniation: A Systematic Review and Network Meta-Analysis.

Evid Based Complement Alternat Med 2019 20;2019:6821310. Epub 2019 Mar 20.

School of Chinese Medicine, Jinan University, Guangzhou, Guangdong Province 510632, China.

Background: Tuina, acupuncture, traction, and Chinese herbs play an important role in the treatment of lumbar disc herniation. However, the comparative effectiveness and safety of the four commonly utilized treatment modalities are still unclear.

Objective: To compare the effectiveness and safety of the four interventions for lumbar disc herniation. Read More

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http://dx.doi.org/10.1155/2019/6821310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446119PMC

Acupuncture to Promote Recovery of Disorder of Consciousness after Traumatic Brain Injury: A Systematic Review and Meta-Analysis.

Evid Based Complement Alternat Med 2019 19;2019:5190515. Epub 2019 Mar 19.

Guangdong Provincial Hospital of Chinese Medicine, Yide Road, Yuexiu District, Guangdong, Guangzhou 510006, China.

Traumatic brain injury (TBI) has become an economic and social burden for patients and their families. While acupuncture is an effective tool for promoting recovery of disorder of consciousness (DOC) following TBI, there have been no comprehensive meta-analyses and/or systematic reviews addressing this topic. The present systematic review and meta-analysis aimed to assess the therapeutic efficacy of acupuncture for DOC after TBI. Read More

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http://dx.doi.org/10.1155/2019/5190515DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444240PMC

Preventive Effect of the Herbal Preparation, HemoHIM, on Cisplatin-Induced Immune Suppression.

Evid Based Complement Alternat Med 2019 20;2019:3494806. Epub 2019 Mar 20.

Department of Neuroscience, Korea University College of Medicine, 145, Anam-ro, Seongbuk-gu, Seoul 02841, Republic of Korea.

We determined the functional effect of the herbal preparation, HemoHIM, on the immune system, by examining the immunomodulatory activities of HemoHIM using immunocompromised mice. In this study, to examine the effect on the restoration of immune cells and balance in the immune system, we utilized a cisplatin-induced immunosuppression mouse model. Mice were injected intraperitoneally with cisplatin, an immunosuppressive anticancer, and then received oral doses of 100, 250, and 500 mg/kg of HemoHIM for 14 days. Read More

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http://dx.doi.org/10.1155/2019/3494806DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446088PMC

Network Pharmacology-Based Study on the Mechanism of Bushen-Jianpi Decoction in Liver Cancer Treatment.

Evid Based Complement Alternat Med 2019 19;2019:3242989. Epub 2019 Mar 19.

Research Center for Traditional Chinese Medicine Complexity System, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, China.

To investigate the mechanism of a Bushen-Jianpi decoction (BSJPD) in liver cancer (LC) treatment, we analyzed clinical therapy data, conducted network pharmacology analysis, and performed pharmacological experimental verification and . The univariate analysis of clinical therapy showed that the BSJPD was protective factor ( < 0.05). Read More

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http://dx.doi.org/10.1155/2019/3242989DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444272PMC

Mongolian Medicine RuXian-I Treatment of Estrogen-Induced Mammary Gland Hyperplasia in Rats Related to TCTP Regulating Apoptosis.

Evid Based Complement Alternat Med 2019 19;2019:1907263. Epub 2019 Mar 19.

Medicinal Chemistry and Pharmacology Institute, Inner Mongolia University for Nationalities, Tongliao, Inner Mongolia, China.

Mongolian medicine RuXian-I is composed of 30 Mongolian herbs, which is a traditional Mongolian recipe for clinical treatment of breast "Qi Su Bu Ri Le Du Sen" disease (hyperplasia of mammary glands, HMG). Based on the previous study, this dissertation further explores the therapeutic mechanism of RuXian-I on estrogen-induced HMG in rats. RuXian-I had no effect on the body weight and food intake of HMG rats and had no toxic effects on the five organs (heart, lung, spleen, and kidney). Read More

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http://dx.doi.org/10.1155/2019/1907263DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444233PMC
March 2019
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Effects of Huanglian-Renshen-Decoction, a Fixed Mixture of Traditional Chinese Medicine, on the Improvement of Glucose Metabolism by Maintenance of Pancreatic Cell Identity in db/db Mice.

Evid Based Complement Alternat Med 2019 19;2019:1232913. Epub 2019 Mar 19.

Institute of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, HuaZhong University of Science and Technology, Wuhan, Hubei 430030, China.

Huanglian-Renshen-Decoction (HRD) is widely used to treat type 2 diabetes mellitus (T2DM) in China. However, the underlying mechanism is unclear. We aimed to investigate the mechanism by which HRD regulates the glucose level. Read More

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http://dx.doi.org/10.1155/2019/1232913DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444265PMC

Investigation of Efficacy Enhancing and Toxicity Reducing Mechanism of Combination of Aconiti Lateralis Radix Praeparata and Paeoniae Radix Alba in Adjuvant-Induced Arthritis Rats by Metabolomics.

Evid Based Complement Alternat Med 2019 18;2019:9864841. Epub 2019 Mar 18.

School of Pharmacy, State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.

Combination of Aconiti Lateralis Radix Praeparata (FZ) and Paeoniae Radix Alba (BS) shows a significant effect in rheumatoid arthritis (RA). This study aimed to investigate the efficacy enhancing and toxicity reducing mechanism of combination of them in adjuvant-induced arthritis (AIA) rats by metabolomics. Rats were randomly divided into seven groups, including A (healthy control), B (model control), C1 (therapy group), C2 (efficacy enhancing group), D1 (toxicity group), and D2 (toxicity reducing group), and dexamethasone group was used as positive control. Read More

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http://dx.doi.org/10.1155/2019/9864841DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442482PMC

Anticonvulsant Effects of Dingxian Pill in Pentylenetetrazol-Kindled Rats.

Evid Based Complement Alternat Med 2019 18;2019:4534167. Epub 2019 Mar 18.

Central Laboratory, Department of Neurology and Neurosurgery, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Dingxian pill has been used as an antiepilepsy agent in China from ancient to modern times, of which the concrete pharmacological characterization and the underlying molecular mechanism remain unclear. The present study was undertaken to investigate them by animal behavior, electroencephalogram (EEG), Morris water maze, immunohistochemistry, transcriptomics, and real-time PCR. In our results, the treatment of Dingxian pill dose-dependently inhibited PTZ-induced seizure-like behavior and reduced the seizure grades, LFP power spectral density, and brain wave of the epileptiform EEG component induced by PTZ. Read More

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http://dx.doi.org/10.1155/2019/4534167DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442303PMC

Cost-Effectiveness Analysis of Xiyanping Injection (Andrographolide Sulfonate) for Treatment of Adult Community Acquired Pneumonia: A Retrospective, Propensity Score-Matched Cohort Study.

Evid Based Complement Alternat Med 2019 18;2019:4510591. Epub 2019 Mar 18.

International Research Center of Medical Administration, Peking University, Beijing, China.

Xiyanping injection (andrographolide sulfonate) has shown clinical effects on community acquired pneumonia. However, there is little known about the effectiveness and costs of combining Xiyanping injection with conventional treatment on adult community acquired pneumonia in daily practice. The aim of this study was to evaluate the cost-effectiveness of combining Xiyanping injection with conventional treatment for treatment of adult community acquired pneumonia by comparing with conventional treatment from a societal perspective. Read More

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https://www.hindawi.com/journals/ecam/2019/4510591/
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http://dx.doi.org/10.1155/2019/4510591DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442483PMC
March 2019
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Observational Application Comparing Problem-Based Learning with the Conventional Teaching Method for Clinical Acupuncture Education.

Authors:
Yun Jin Kim

Evid Based Complement Alternat Med 2019 18;2019:2102304. Epub 2019 Mar 18.

School of Traditional Chinese Medicine, Xiamen University Malaysia, Jalan Sunsuria, Bandar Sunsuria, Sepang, Selangor 43900, Malaysia.

Aim: Although the problem-based learning (PBL) teaching method was introduced in 1969, its rapid and widespread application in Malaysia started in 1979. This study aimed to evaluate satisfaction with PBL compared to that of conventional learning, using satisfaction surveys and the Rosenberg Self-Esteem scores, of students learning clinical acupuncture at the School of Traditional Chinese Medicine (TCM), Xiamen University Malaysia.

Method: The participants of this study (N=36) were registered for a bachelor's degree program in TCM in 2016 and enrolled in the Science of Acupuncture and Moxibustion course beginning in September 2018. Read More

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http://dx.doi.org/10.1155/2019/2102304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442311PMC

Formononetin Enhances the Tumoricidal Effect of Everolimus in Breast Cancer MDA-MB-468 Cells by Suppressing the mTOR Pathway.

Evid Based Complement Alternat Med 2019 17;2019:9610629. Epub 2019 Mar 17.

Pathology Department, Baoshan Branch, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201900, China.

Background: Formononetin, an active ingredient isolated from the traditional Chinese medicinal herb , has anticancer and chemoresistance-reducing biological activities. We evaluated the efficacy of formononetin in improving the tumoricidal effect of everolimus by suppressing the mTOR pathway in breast cancer cells.

Methods: Cell survival was assessed using an MTT assay. Read More

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https://www.hindawi.com/journals/ecam/2019/9610629/
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http://dx.doi.org/10.1155/2019/9610629DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441524PMC
March 2019
1 Read

Curcumin and Curcumol Inhibit NF-B and TGF-/Smads Signaling Pathways in CSE-Treated RAW246.7 Cells.

Evid Based Complement Alternat Med 2019 17;2019:3035125. Epub 2019 Mar 17.

Faculty of Basic Medical Sciences, Yunnan University of Chinese Medicine, Yuhua Road, No. 1024, Kunming 650500, Yunnan, China.

E-Zhu () is known as a classical traditional Chinese medicine and widely used in the treatment of cancers, cardiovascular disease, inflammation, and other diseases. Its main components include curcumol and curcumin, which have anti-inflammatory and antifibrosis effects. Here we established an inflammatory injury model by stimulating RAW246. Read More

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https://www.hindawi.com/journals/ecam/2019/3035125/
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http://dx.doi.org/10.1155/2019/3035125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441512PMC
March 2019
1 Read

Danggui Shaoyao San Ameliorates Renal Fibrosis via Regulation of Hypoxia and Autophagy.

Evid Based Complement Alternat Med 2019 17;2019:2985270. Epub 2019 Mar 17.

Teaching and Research Department of Basic Theory of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China.

Danggui Shaoyao San (DSS), a traditional Chinese medicinal prescription, was widely used to reinforce earth to activate collaterals in ancient times. Recently, many clinical studies found that DSS had a renoprotection. In this study, we evaluated the effect of DSS on unilateral ureteral obstruction- (UUO-) induced renal fibrosis in rats and investigated the mechanisms underlying the effect. Read More

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http://dx.doi.org/10.1155/2019/2985270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441542PMC

The Difference of Chemical Components and Biological Activities of the Raw Products slices and the Wine Steam-Processed Product from Cistanche deserticola.

Evid Based Complement Alternat Med 2019 17;2019:2167947. Epub 2019 Mar 17.

School of Chinese Materia Medica, Beijing University of Chinese Medicine, Liangxiang Higher Education Park, Beijing 102488, China.

As a well-known Chinese herb medicine, the Cistanche deserticola has been used for the treatment of kidney deficiency syndrome in China for thousands of years. Both the raw product of Cistanche deserticola slices (RCD) and its Wine Steam-Processed Product (WSCD) are used clinically for different effects. In this study, the influences of steaming process with wine (SPW) from Cistanche deserticola on chemical compositions and biological effects were investigated. Read More

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http://dx.doi.org/10.1155/2019/2167947DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441511PMC

Pharmacological Prevention of Postoperative Delirium: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Evid Based Complement Alternat Med 2019 14;2019:9607129. Epub 2019 Mar 14.

Department of Intensive Care Unit, West China Hospital of Sichuan University, Chengdu, China.

Background: The high prevalence of delirium among postoperative patients has increased morbidity and mortality. The kind of drug that can effectively reduce the incidence of delirium has become the focus of discussion in recent years. However, a consensus in this respect has yet to be reached. Read More

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http://dx.doi.org/10.1155/2019/9607129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437723PMC

Chinese Herbal Complex 'Bu Shen Jie Du Fang' (BSJDF) Modulated Autophagy in an MPP-Induced Cell Model of Parkinson's Disease.

Evid Based Complement Alternat Med 2019 13;2019:8920813. Epub 2019 Mar 13.

Department of Chinese Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China.

Autophagy plays an important role in the development of Parkinson disease (PD). Previous studies showed that autophagy could protect cells from -synuclein toxicity and promote functional coupling of mitochondria. But it is still a question whether modulating autophagy can be used to treat PD. Read More

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http://dx.doi.org/10.1155/2019/8920813DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436328PMC

Qiliqiangxin Capsule Improves Cardiac Function and Attenuates Cardiac Remodeling by Upregulating miR-133a after Myocardial Infarction in Rats.

Evid Based Complement Alternat Med 2019 14;2019:7528214. Epub 2019 Mar 14.

Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Beijing 100700, China.

Qiliqiangxin capsule (QLC), a natural herb recipe with therapeutic effect from China, has been widely used in clinical practice for attenuating cardiac remodeling induced by myocardial infarction (MI). However, the pharmacological mechanism of QLC on cardiac remodeling after MI is not entirely clear. The present study aims to investigate the effectiveness and mechanisms of QLC on cardiac remodeling induced by MI in rats. Read More

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http://dx.doi.org/10.1155/2019/7528214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437749PMC

Simiao Pill Attenuates Collagen-Induced Arthritis in Rats through Suppressing the ATX-LPA and MAPK Signalling Pathways.

Evid Based Complement Alternat Med 2019 14;2019:7498527. Epub 2019 Mar 14.

Department of Integrated Chinese Traditional and Western Medicine, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, 430070, China.

Objective: Simiao pill (SM), a traditional Chinese formula, has been used as an antirheumatic drug in clinical practice for hundreds of years. Rheumatoid arthritis (RA) is characterized by chronic synovial inflammation and hyperplasia, cartilage destruction, and joint damage. This study was designed to investigate the protective effects of SM on collagen-induced arthritis (CIA) in rats. Read More

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http://dx.doi.org/10.1155/2019/7498527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437962PMC

Fruit Extract Ameliorates Experimental Autoimmune Encephalomyelitis through the Regulation of Th1/Th17 Cells.

Evid Based Complement Alternat Med 2019 14;2019:6797030. Epub 2019 Mar 14.

Department of Life Science, Institute of Biotechnology, National Tsing Hua University, Hsinchu 30013, Taiwan.

is a traditional Chinese medicine widely used for treating diarrhea, ulceration, and enuresis. Moreover, is effective for cognitive function improvement and nerve regeneration. Multiple sclerosis (MS) is a chronic neuronal inflammatory autoimmune disease that commonly affects young adults in high-latitude regions. Read More

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https://www.hindawi.com/journals/ecam/2019/6797030/
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http://dx.doi.org/10.1155/2019/6797030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437745PMC
March 2019
1 Read

In Vitro Antiatherothrombotic Effects of Extracts from L., L., and Benth.

Evid Based Complement Alternat Med 2019 14;2019:3245836. Epub 2019 Mar 14.

Food and Science Technology Research Centre, MARDI, Serdang, Selangor, Malaysia.

Coronary artery disease is the leading cause of mortality and morbidity worldwide. The pathogenesis is mainly due to atherosclerosis, plaque rupture, and platelet thrombus formation. The main risk factors for coronary artery disease include obesity, hypercholesterolemia, smoking, diabetes, and high blood pressure. Read More

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https://www.hindawi.com/journals/ecam/2019/3245836/
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http://dx.doi.org/10.1155/2019/3245836DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437728PMC
March 2019
2 Reads

Inhibition of Cytochrome P450 Activities by Extract and Its Prenylated Flavonoids in Human Liver Microsomes.

Evid Based Complement Alternat Med 2019 13;2019:2673769. Epub 2019 Mar 13.

Department of Pharmacology and Pharmacogenomics Research Center, Inje University College of Medicine, Busan 614-735, Republic of Korea.

possesses several pharmacological properties and has been widely used for the treatment of diarrhea, inflammation, abscess, dysentery, and fever in East Asian countries. is a major source of prenylated flavonoids, such as sophoraflavone and kushenol. In this study, we examined the effects of extract and its prenylated flavonoids on cytochrome P450 (CYP) isoform activity in human liver microsomes. Read More

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http://dx.doi.org/10.1155/2019/2673769DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436327PMC
March 2019
1 Read

Comparison of the Efficacy between Conventional Moxibustion and Smoke-Free Moxibustion on Knee Osteoarthritis: A Randomized Controlled Trial.

Evid Based Complement Alternat Med 2019 14;2019:1291947. Epub 2019 Mar 14.

School of Acupuncture and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.

Objective: The aim of this study was to investigate the difference of efficacy between conventional moxibustion (CM) and smoke-free moxibustion (SM) for patients with osteoarthritis of the knee (KOA).

Methods: This is a multicentre, randomized, single blinded, parallel-group clinical trial. Patients with KOA were randomly allocated to CM group (69) and SM group (69) in 7 hospitals of China. Read More

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http://dx.doi.org/10.1155/2019/1291947DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437731PMC

Effects of Water/Ethanol Extract on -Induced Diarrhea in Rats.

Evid Based Complement Alternat Med 2019 12;2019:9537603. Epub 2019 Mar 12.

Animal Physiology Laboratory, Faculty of Science, University of Yaoundé I, Cameroon.

Diarrheal disease, characterized by the release of more than three loose or liquid stools per day, remains one of the leading causes of morbidity and mortality in children below 5 years of age in developing countries. Many drugs used in diarrhea management face contraindication and, with regard to infectious diarrhea, resistance of some bacterial strains; this therefore increases the need of new alternative and more effective drugs. This study aimed to evaluate anti- activities of water/ethanol extract. Read More

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https://www.hindawi.com/journals/ecam/2019/9537603/
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http://dx.doi.org/10.1155/2019/9537603DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434311PMC
March 2019
1 Read

Disodium Cantharidinate and Vitamin B6 Injection Adjunct with Platinum-Based Chemotherapy for the Treatment of Advanced Non-Small-Cell Lung Cancer: A Meta-Analysis.

Evid Based Complement Alternat Med 2019 12;2019:9386273. Epub 2019 Mar 12.

Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, China.

Purpose: Disodium cantharidinate and vitamin B6 (DCVB6) injection is effective and widely used for the clinical treatment of non-small-cell lung cancer (NSCLC). This meta-analysis aimed to provide evidence-based medical data for clinical treatment with DCVB6 injection.

Methods: We searched 7 medical databases up to January 2018 for all randomized controlled trials (RCTs) based on DCVB6 injection combined with chemotherapy in patients with NSCLC. Read More

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http://dx.doi.org/10.1155/2019/9386273DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434307PMC
March 2019
1 Read

Effectiveness of Acupuncturing at the Sphenopalatine Ganglion Acupoint Alone for Treatment of Allergic Rhinitis: A Systematic Review and Meta-Analysis.

Evid Based Complement Alternat Med 2019 12;2019:6478102. Epub 2019 Mar 12.

School of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu 610072, China.

Aims: To evaluate the efficiency of acupuncturing at the sphenopalatine ganglion acupoint alone for treatment of allergic rhinitis.

Design: A total of ten online databases were searched to find studies published up to Jan. 2018. Read More

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http://dx.doi.org/10.1155/2019/6478102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434301PMC
March 2019
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Meta-Analysis of Xihuang Pill Efficacy When Combined with Chemotherapy for Treatment of Breast Cancer.

Evid Based Complement Alternat Med 2019 12;2019:3502460. Epub 2019 Mar 12.

Department of Integrated Traditional Chinese and Western Internal Medicine, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410000, China.

Objective: To systematically evaluate the efficacy of Xihuang pill (XHP) in breast cancer patients receiving chemotherapy.

Methods: Three English and four Chinese databases were searched. Literature was screened using EndNote X7 and data were analyzed by Review Manager. Read More

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https://www.hindawi.com/journals/ecam/2019/3502460/
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http://dx.doi.org/10.1155/2019/3502460DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434299PMC
March 2019
2 Reads

Effect of Plastrum Testudinis Extracts on the Proliferation and Osteogenic Differentiation of rBMSCs by Regulating p38 MAPK-Related Genes.

Evid Based Complement Alternat Med 2019 7;2019:6815620. Epub 2019 Mar 7.

Shanghai University of Chinese Medicine, Shanghai 200032, China.

Extracts from plastrum testudinis (PTE) are active compounds that have been used to treat bone diseases in traditional Chinese medicine for thousands of years. In previous studies, we demonstrated their effects on glucocorticoid-induced osteoporosis both and . However, the mechanisms by which PTE regulates the osteogenic differentiation of rat bone marrow-derived mesenchymal stem cells (rBMSCs) remain poorly understood. Read More

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http://dx.doi.org/10.1155/2019/6815620DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431499PMC
March 2019
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1.880 Impact Factor

The Antitumor Effect of Curcumin in Urothelial Cancer Cells Is Enhanced by Light Exposure In Vitro.

Evid Based Complement Alternat Med 2019 11;2019:6374940. Epub 2019 Mar 11.

Department of Urology, Goethe-University, Frankfurt am Main, Germany.

The natural compound curcumin exerts antitumor properties in vitro, but its clinical application is limited due to low bioavailability. Light exposure in skin and skin cancer cells has been shown to improve curcumin bioavailability; thus, the object of this investigation was to determine whether light exposure might also enhance curcumin efficacy in bladder cancer cell lines. RT112, UMUC3, and TCCSUP cells were preincubated with low curcumin concentrations (0. Read More

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http://dx.doi.org/10.1155/2019/6374940DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432698PMC

Acupuncture-Analgesia-Mediated Alleviation of Central Sensitization.

Evid Based Complement Alternat Med 2019 7;2019:6173412. Epub 2019 Mar 7.

Department of Chinese Medicine, China Medical University Hospital, Taichung 40447, Taiwan.

Pain can trigger central amplification called central sensitization, which ultimately results in hyperalgesia and/or allodynia. Many reports have showed acupuncture has an analgesic effect. We searched the related article on PubMed database and Cochrane database to discover central sensitization pathway in acupuncture analgesia. Read More

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http://dx.doi.org/10.1155/2019/6173412DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431485PMC
March 2019
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Amelioration of CCl-Induced Hepatotoxicity in Rabbits by Seeds.

Evid Based Complement Alternat Med 2019 7;2019:5947234. Epub 2019 Mar 7.

Biochemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.

The current study aimed to evaluate the probable protective effect of seeds (LSS) against CCl induced hepatic injury in New-Zealand rabbits. Rabbits were randomly divided into two main groups; group-A (noninjured group, n=15) was divided to subgroups A1 (untreated control) and A2 and A3 which received 200 & 400 mg/kg bw of LSS, respectively, in their diet daily. Group-B (injured group, n=30) were subcutaneously injected with CCl (0. Read More

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https://www.hindawi.com/journals/ecam/2019/5947234/
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http://dx.doi.org/10.1155/2019/5947234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431501PMC
March 2019
3 Reads

Nerol Attenuates Ouabain-Induced Arrhythmias.

Evid Based Complement Alternat Med 2019 7;2019:5935921. Epub 2019 Mar 7.

Laboratory of Heart Biophysics, Department of Physiology, Federal University of Sergipe, São Cristóvão, Brazil.

Nerol (CHO) is a monoterpene found in many essential oils, such as lemon balm and hop. In this study, we explored the contractile and electrophysiological properties of nerol and demonstrated its antiarrhythmic effects in guinea pig heart preparation. Nerol effects were evaluated on atrial and ventricular tissue contractility, electrocardiogram (ECG), voltage-dependent L-type Ca current (I), and ouabain-triggered arrhythmias. Read More

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http://dx.doi.org/10.1155/2019/5935921DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431517PMC

The Antioxidative Action of ZTP by Increasing Nrf2/ARE Signal Pathway.

Evid Based Complement Alternat Med 2019 10;2019:5421528. Epub 2019 Mar 10.

School of Life Science, Beijing Institute of Technology, Beijing 100081, China.

So far, more than 25,000 brain diseases have been shown to be related to oxidative stress. Excessive free radicals and reactive oxygen species (ROS) can attack cells resulting in dysfunctional proteins, lipids, and nucleic acid, finally leading to imbalance of energy metabolism, cell death, gene mutation, and immune reaction. Therefore oxidative stress plays an important role in neuronal diseases. Read More

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https://www.hindawi.com/journals/ecam/2019/5421528/
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http://dx.doi.org/10.1155/2019/5421528DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431467PMC
March 2019
2 Reads

MicroRNAs in the Progress of Diabetic Nephropathy: A Systematic Review and Meta-Analysis.

Evid Based Complement Alternat Med 2019 7;2019:3513179. Epub 2019 Mar 7.

Department of Experimental Pharmacology and Toxicology, School of Pharmacy, Jilin University, Changchun, China.

Background: We conducted a systematic review and meta-analysis of existing literature to evaluate the different outcomes of microRNAs (miRNAs) in diabetic nephropathy (DN), including urinary albumin excretion rates, urinary albumin creatinine rates, glomerular filtration rate, HbAc1, and creatinine.

Methods: Electronic databases including PUBMED, MEDLINE, and EMBASE were searched for eligible publications to July 2018. The following comparisons between treatment groups were included: normal group versus DN group; control group versus micro/macroalbuminuria group. Read More

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https://www.hindawi.com/journals/ecam/2019/3513179/
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http://dx.doi.org/10.1155/2019/3513179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431481PMC
March 2019
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Corrigendum to "Toll-Like Receptor 4-Myeloid Differentiation Primary Response Gene 88 Pathway Is Involved in the Shikonin Treatment of CIA by Regulating Treg/Th17 Expression".

Evid Based Complement Alternat Med 2019 7;2019:2198708. Epub 2019 Mar 7.

Department of Chinese Medicine, Heilongjiang University of Chinese Medicine, Harbin, China.

[This corrects the article DOI: 10.1155/2018/2428546.]. Read More

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http://dx.doi.org/10.1155/2019/2198708DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431497PMC

Antibacterial and Antibiotic Modifying Potential of Crude Extracts, Fractions, and Compounds from Willd. against MDR Gram-Negative Bacteria.

Evid Based Complement Alternat Med 2019 7;2019:7507549. Epub 2019 Mar 7.

Department of Biochemistry, Faculty of Science, University of Dschang, Dschang, Cameroon.

The present study aimed to assess the antibacterial and antibiotic modifying activities of methanol extracts prepared from the leaf (APL) and bark (APB) of , fractions (APLa-d) and compounds isolated from APL against a panel of multidrug resistant (MDR) Gram-negative bacteria. Leaf extract was subjected to column chromatography for compounds isolation; antibacterial assays were performed on samples alone and with an efflux pump inhibitor (EPI), respectively, and several antibiotics on the tested bacteria. The phytochemical investigation of APL led to the isolation of stigmasterol (), -amyrin (), 3---glucopyranosylstigmasterol (), 3-O-methyl-D-chiro-inositol (), epicatechin (), quercetin-3--glucoside (), 3--[--xylopyranosyl-(1→4)---galactopyranosyl]-oleanolic acid (), and 3--[-galactopyranosyl-(1→4)---galactopyranosyl]-oleanolic acid (). Read More

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http://dx.doi.org/10.1155/2019/7507549DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431460PMC
March 2019
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Acute and Subacute Toxicity of Methanol Extract of Leaves on the Histology of the Liver and Kidney and Biochemical Compositions of Blood in Rats.

Evid Based Complement Alternat Med 2019 10;2019:5702159. Epub 2019 Mar 10.

Directorate of Traditional and Modern Medicine Research, Ethiopian Public Health Institute, Addis Ababa, Ethiopia.

Plant medicine is the oldest form of health care known to mankind. is one of the many species of Ethiopian medicinal plants which has a long history of use as remedies for various ailments such as dysentery, diarrhea, and hypertension. In many countries, herbal medicines and related products are introduced into the market without safety or toxicological evaluation. Read More

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http://dx.doi.org/10.1155/2019/5702159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431459PMC

Adenosine A2A Receptor Mediates Inhibition of Synovitis and Osteoclastogenesis after Electroacupuncture in Rats with Collagen-Induced Arthritis.

Evid Based Complement Alternat Med 2019 6;2019:4617464. Epub 2019 Mar 6.

Department of Acupuncture, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China.

Background: This study was to investigate the role of adenosine A2A receptors (A2AR) in inhibiting the effect of electroacupuncture (EA) on osteoclastogenesis in collagen-induced arthritis (CIA).

Methods: Wistar rats were divided into four groups: sham-control group, CIA-control group, CIA-EA group, and CIA-EA-SCH58261 (A2AR antagonist) group. We detected tumor necrosis factor- (TNF-), nuclear transcription factor-B (NF-B), receptor activator of NF-B ligand (RANKL), protein kinase A (PKA), and extracellular regulatory protein kinase 1/2 (ERK1/2) in peripheral blood by ELISA. Read More

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https://www.hindawi.com/journals/ecam/2019/4617464/
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http://dx.doi.org/10.1155/2019/4617464DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431381PMC
March 2019
2 Reads

Effects of Interactive Video Game-Based Exercise on Balance in Diabetic Patients with Peripheral Neuropathy: An Open-Level, Crossover Pilot Study.

Evid Based Complement Alternat Med 2019 6;2019:4540709. Epub 2019 Mar 6.

Department of Physical Medicine and Rehabilitation, Taipei Medical University Hospital, Taipei, Taiwan.

This study evaluated the effects of interactive video game-based (IVGB) exercise on balance in diabetic patients with peripheral neuropathy. Twenty-four patients were randomly assigned to two groups (12 participants per group). Group A received IVGB training for the first 6 weeks, with no exercise in the subsequent 6 weeks. Read More

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http://dx.doi.org/10.1155/2019/4540709DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431378PMC
March 2019
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Effect of Herb-Partitioned Moxibustion on Autophagy and Immune-Associated Gene Expression Profiles in a Rat Model of Crohn's Disease.

Evid Based Complement Alternat Med 2019 7;2019:3405146. Epub 2019 Mar 7.

Shanghai Qigong Research Institute, Shanghai University of Traditional Chinese Medicine, Shanghai 200030, China.

Objective: To investigate the immune regulation mechanism of herb-partitioned moxibustion in rats with Crohn's disease (CD) focusing on autophagy.

Methods: Rats were randomly divided into normal (N) group, CD model (M) group, CD model with herb-partitioned moxibustion (MM) group, normal with herb-partitioned moxibustion (NM) group, CD model with mesalazine (western medicine, Med ) group, and normal saline (NS) group, with 10 rats in each group. The CD model rats were prepared by trinitrobenzene sulphonic expect for the N group and NM group. Read More

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http://dx.doi.org/10.1155/2019/3405146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431444PMC
March 2019
3 Reads

(Indian and Chinese Bitter Melon) Extracts Inducing Apoptosis in Human Lung Cancer Cell Line A549 via ROS-Mediated Mitochodria Injury.

Evid Based Complement Alternat Med 2019 6;2019:2821597. Epub 2019 Mar 6.

Department of Human Anatomy, Faculty of Medicine and Health Science, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.

Lung cancer is the leading cause of cancer related deaths worldwide with about 40% occurring in developing countries. The two varieties of , which are Chinese and Indian bitter melon, have been subjected to antiproliferative activity in human non-small cell lung cells A549. The A549 cells were treated with hot and cold aqueous extraction for both the bitter melon varieties, and the antiproliferative activity was evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Read More

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http://dx.doi.org/10.1155/2019/2821597DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431397PMC
March 2019
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Pharmacological Effects of Verticine: Current Status.

Evid Based Complement Alternat Med 2019 7;2019:2394605. Epub 2019 Mar 7.

Zhengzhou Key Laboratory of Medicinal Resources Research, Huanghe Science and Technology College, Zhengzhou 450063, China.

Verticine is the major bioactive constituent of as a kind of Traditional Chinese Medicine. Pharmacological researches have reported various benefits of verticine, including anticancer, anti-inflammatory, protecting against acute lung injury, tracheobronchial relaxation, antitussive, expectorant, sedative, and analgesic activities, in addition to inhibiting proliferation of cultured orbital fibroblast, angiotensin converting enzyme (ACE), and acetylcholinesterase (AChE) and inhibiting hERG potassium channels. The underlying mechanisms of verticine are still under investigation. Read More

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http://dx.doi.org/10.1155/2019/2394605DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431433PMC
March 2019
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1.880 Impact Factor

Toxicity Assessment of Chinese Herbal Medicine Rupr.

Evid Based Complement Alternat Med 2019 4;2019:9819643. Epub 2019 Mar 4.

Beijing Key Laboratory of Bioactive Substances and Functional Food, Beijing Union University, Beijing, China.

Rupr, known as Suo Yang, is most commonly used to treat fatigue, protect the liver, and invigorate kidneys in Northwest China. Given the wide medicinal utilisation and lack of safety evaluation, this work evaluated the acute toxicity, genetic toxicity, and 90-day repeated oral toxicity of Suo Yang. Twenty Kunming mice were orally given Suo Yang once and observed for 14 days in the acute toxicity test. Read More

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https://www.hindawi.com/journals/ecam/2019/9819643/
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http://dx.doi.org/10.1155/2019/9819643DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425418PMC
March 2019
2 Reads
1.880 Impact Factor

Baicalein Inhibits Orthotopic Human Non-Small Cell Lung Cancer Xenografts via Src/Id1 Pathway.

Evid Based Complement Alternat Med 2019 4;2019:9806062. Epub 2019 Mar 4.

The Department of Integrative Medicine, Huashan Hospital, Fudan University, 12 Middle Urumqi Road, Shanghai 200040, China.

Non-small cell lung cancer (NSCLC) is one of the most lethal cancers worldwide. Inhibitor of differentiation 1 (Id1) is the member mostly linked to tumorigenesis in Id family and a potential molecular target in cancer therapy. In the current study, we established an orthotopic lung cancer model by injecting athymic nude mice with A549 cells and evaluated the antitumor effect of baicalein and expression of Id1-related proteins and . Read More

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http://dx.doi.org/10.1155/2019/9806062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425425PMC
March 2019
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Quantitative Data for Transcutaneous Electrical Nerve Stimulation and Acupuncture Effectiveness in Treatment of Fibromyalgia Syndrome.

Evid Based Complement Alternat Med 2019 4;2019:9684649. Epub 2019 Mar 4.

Department of Computer Engineering, Engineering Faculty of Başkent University, Ankara, Turkey.

. To evaluate the effects of acupuncture and transcutaneous electric nerve stimulation (TENS) applications on the quantitative electroencephalography (qEEG) changes and to evaluate their therapeutic effects in patients with fibromyalgia syndrome (FMS). The study included 42 patients with FMS and 21 healthy volunteers. Read More

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http://dx.doi.org/10.1155/2019/9684649DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425376PMC