92 results match your criteria Evidence-Based Ophthalmology[Journal]


Evidence-Based Insights into the Utility of Conjunctival Biopsy in Mucous Membrane Pemphigoid.

Authors:
Todd Margolis

Ophthalmology 2018 Apr;125(4):474-475

Washington University School of Medicine, Department of Ophthalmology and Visual Sciences, St. Louis, Missouri. Electronic address:

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http://dx.doi.org/10.1016/j.ophtha.2018.01.014DOI Listing
April 2018
2 Reads

Guidance on Noncorticosteroid Systemic Immunomodulatory Therapy in Noninfectious Uveitis: Fundamentals Of Care for UveitiS (FOCUS) Initiative.

Ophthalmology 2018 May 6;125(5):757-773. Epub 2018 Jan 6.

Ophthalmology, Bristol Eye Hospital, University Hospitals Bristol NHS Foundation Trust, Bristol, United Kingdom; Manchester Royal Eye Hospital, Central Manchester University Hospitals, and University of Manchester, Manchester Academic Health Sciences Centre, Manchester, United Kingdom.

Topic: An international, expert-led consensus initiative to develop systematic, evidence-based recommendations for the treatment of noninfectious uveitis in the era of biologics.

Clinical Relevance: The availability of biologic agents for the treatment of human eye disease has altered practice patterns for the management of noninfectious uveitis. Current guidelines are insufficient to assure optimal use of noncorticosteroid systemic immunomodulatory agents. Read More

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http://dx.doi.org/10.1016/j.ophtha.2017.11.017DOI Listing
May 2018
17 Reads

Fragility of Results in Ophthalmology Randomized Controlled Trials: A Systematic Review.

Ophthalmology 2018 May 11;125(5):642-648. Epub 2017 Dec 11.

Division of Ophthalmology, Department of Surgery, McMaster University, Hamilton, Ontario, Canada; McMaster Paediatric Eye Research Group, Department of Surgery, McMaster University, Hamilton, Ontario, Canada; McMaster Pediatric Surgery Research Collaborative, Department of Surgery, McMaster University, Hamilton, Ontario, Canada.

Purpose: Evidence-based medicine is guided by our interpretation of randomized controlled trials (RCTs) that address important clinical questions. Evaluation of the robustness of statistically significant outcomes adds a crucial element to the global assessment of trial findings. The purpose of this systematic review was to determine the robustness of ophthalmology RCTs through application of the Fragility Index (FI), a novel metric of the robustness of statistically significant outcomes. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01616420173198
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http://dx.doi.org/10.1016/j.ophtha.2017.11.015DOI Listing
May 2018
18 Reads

Neuropathic Corneal Pain: Approaches for Management.

Ophthalmology 2017 11;124(11S):S34-S47

Cornea Service, New England Eye Center, Department of Ophthalmology, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts; Center for Translational Ocular Immunology, Department of Ophthalmology, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts. Electronic address:

Neuropathic pain is caused by a primary lesion or dysfunction of the nervous system and can occur in the cornea. However, neuropathic corneal pain (NCP) is currently an ill-defined disease. Patients with NCP are extremely challenging to manage, and evidence-based clinical recommendations for the management of patients with NCP are scarce. Read More

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http://dx.doi.org/10.1016/j.ophtha.2017.08.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5743225PMC
November 2017
6 Reads

Evidence-based Criteria for Assessment of Visual Field Reliability.

Ophthalmology 2017 11 1;124(11):1612-1620. Epub 2017 Jul 1.

Glaucoma Center of Excellence, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland; Dana Center for Preventive Ophthalmology, Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland. Electronic address:

Purpose: Assess the impact of false-positives (FP), false-negatives (FN), fixation losses (FL), and test duration (TD) on visual field (VF) reliability at different stages of glaucoma severity.

Design: Retrospective.

Participants: A total of 10 262 VFs from 1538 eyes of 909 subjects with suspect or manifest glaucoma and ≥5 VF examinations. Read More

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http://dx.doi.org/10.1016/j.ophtha.2017.04.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5675138PMC
November 2017
9 Reads

Construction and implications of structural equation modeling network for pediatric cataract: a data mining research of rare diseases.

BMC Ophthalmol 2017 May 19;17(1):74. Epub 2017 May 19.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, 510060, China.

Background: The majority of rare diseases are complex diseases caused by a combination of multiple morbigenous factors. However, uncovering the complex etiology and pathogenesis of rare diseases is difficult due to limited clinical resources and conventional statistical methods. This study aims to investigate the interrelationship and the effectiveness of potential factors of pediatric cataract, for the exploration of data mining strategy in the scenarios of rare diseases. Read More

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http://dx.doi.org/10.1186/s12886-017-0468-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438536PMC
May 2017
51 Reads

Associations between matrix metalloproteinase gene polymorphisms and glaucoma susceptibility: a meta-analysis.

BMC Ophthalmol 2017 Apr 21;17(1):48. Epub 2017 Apr 21.

Department of Neurology, Center for Evidence-Based Medicine and Clinical Research, Taihe Hospital, Hubei University of Medicine, 32 South Renmin Road, Shiyan, 442000, China.

Background: Matrix metalloproteinases (MMPs) polymorphisms have been implicated in the pathogenesis of glaucoma risk. However, the results were controversial. We performed a meta-analysis to evaluate the precise associations between MMPs polymorphisms and glaucoma risk. Read More

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http://dx.doi.org/10.1186/s12886-017-0442-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5401566PMC
April 2017
15 Reads

Predictive Medicine in Ophthalmology.

Ophthalmology 2017 04;124(4):420-421

East Melbourne, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.ophtha.2016.12.018DOI Listing
April 2017
2 Reads

Orbital/Periorbital Plexiform Neurofibromas in Children with Neurofibromatosis Type 1: Multidisciplinary Recommendations for Care.

Ophthalmology 2017 01 3;124(1):123-132. Epub 2016 Nov 3.

Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland.

Topic: Children and adults with neurofibromatosis type 1 (NF1), a common autosomal dominant condition, manifest a variety of ophthalmologic conditions. Plexiform neurofibromas (PNs) involving the eyelid, orbit, periorbital, and facial structures (orbital-periorbital plexiform neurofibroma [OPPN]) can result in significant visual loss in children. Equally important, OPPNs can cause significant alteration in physical appearance secondary to proptosis, ptosis, and facial disfigurement, leading to social embarrassment and decreased self-esteem. Read More

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http://dx.doi.org/10.1016/j.ophtha.2016.09.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5173440PMC
January 2017
21 Reads

The Evolution of the American Board of Ophthalmology Written Qualifying Examination.

Ophthalmology 2016 09;123(9 Suppl):S15-9

American Board of Ophthalmology, Bala Cynwyd, Pennsylvania; Department of Ophthalmology, Medical College of Wisconsin, Milwaukie, Wisconsin.

Since the inception of board certification in ophthalmology in 1916, a written assessment of candidates' knowledge base has been an integral part of the certification process. Although the committee structure and technique for writing examination questions has evolved over the past 100 years, the written qualifying examination remains an essential tool for assessing the competency of physicians entering the workforce. To develop a fair and valid examination, the American Board of Ophthalmology builds examination questions using evidence-based, peer-reviewed literature and adheres to accepted psychometric assessment standards. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01616420163044
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http://dx.doi.org/10.1016/j.ophtha.2016.06.011DOI Listing
September 2016
6 Reads

Readability of patient education materials in ophthalmology: a single-institution study and systematic review.

BMC Ophthalmol 2016 Aug 3;16:133. Epub 2016 Aug 3.

Duke University Department of Ophthalmology, Durham, NC, USA.

Background: Patient education materials should be written at a level that is understandable for patients with low health literacy. The aims of this study are (1) to review the literature on readability of ophthalmic patient education materials and (2) to evaluate and revise our institution's patient education materials about glaucoma using evidence-based guidelines on writing for patients with low health literacy.

Methods: A systematic search was conducted on the PubMed/MEDLINE database for studies that have evaluated readability level of ophthalmic patient education materials, and the reported readability scores were assessed. Read More

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http://bmcophthalmol.biomedcentral.com/articles/10.1186/s128
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http://dx.doi.org/10.1186/s12886-016-0315-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973096PMC
August 2016
5 Reads

United Kingdom National Ophthalmology Database Study of Cataract Surgery: Report 3: Pseudophakic Retinal Detachment.

Ophthalmology 2016 08 21;123(8):1711-1715. Epub 2016 Jun 21.

The Royal College of Ophthalmologists' National Ophthalmology Database, London, United Kingdom; Gloucestershire Hospitals NHS Foundation Trust, Cheltenham, United Kingdom. Electronic address:

Purpose: To investigate time to pseudophakic retinal detachment (RD) after cataract surgery with posterior capsule rupture (PCR) to provide an evidence-based guide for postoperative management.

Design: Retrospective case series.

Participants: A total of 61 907 eyes of 46 824 patients undergoing cataract surgery. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01616420163009
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http://dx.doi.org/10.1016/j.ophtha.2016.04.002DOI Listing
August 2016
9 Reads

Interventions for Age-Related Macular Degeneration: Are Practice Guidelines Based on Systematic Reviews?

Ophthalmology 2016 Apr 22;123(4):884-97. Epub 2016 Jan 22.

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.

Purpose: Are existing systematic reviews of interventions for age-related macular degeneration incorporated into clinical practice guidelines?

Design: High-quality systematic reviews should be used to underpin evidence-based clinical practice guidelines and clinical care. We examined the reliability of systematic reviews of interventions for age-related macular degeneration (AMD) and described the main findings of reliable reviews in relation to clinical practice guidelines.

Methods: Eligible publications were systematic reviews of the effectiveness of treatment interventions for AMD. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01616420150142
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http://dx.doi.org/10.1016/j.ophtha.2015.12.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4808456PMC
April 2016
7 Reads

Primary Open-Angle Glaucoma Suspect Preferred Practice Pattern(®) Guidelines.

Ophthalmology 2016 Jan 12;123(1):P112-51. Epub 2015 Nov 12.

Wheaton Eye Clinic, Wheaton, Illinois.

Unlabelled: PRIMARY OPEN-ANGLE GLAUCOMA SUSPECT PREFERRED PRACTICE PATTERN®

Guidelines: Evidence-based update of the Primary Open-Angle Suspect Glaucoma Preferred Practice Pattern® (PPP) guidelines, describing the diagnosis and management of patients with primary open-angle glaucoma suspect with detailed recommendations for evaluation and treatment options. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01616420150127
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http://dx.doi.org/10.1016/j.ophtha.2015.10.055DOI Listing
January 2016
14 Reads

Retinal Vein Occlusions Preferred Practice Pattern(®) Guidelines.

Ophthalmology 2016 Jan 12;123(1):P182-208. Epub 2015 Nov 12.

Emory Eye Center, Emory University, Atlanta, Georgia.

Unlabelled: RETINAL VEIN OCCLUSIONS PREFERRED PRACTICE PATTERN®

Guidelines: New evidence-based Retinal Vein Occlusions Preferred Practice Pattern® (PPP) guidelines, discussing the prognosis and risk factors of retinal vein occlusions and the treatment options. Read More

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http://dx.doi.org/10.1016/j.ophtha.2015.10.045DOI Listing
January 2016
13 Reads

Comprehensive Adult Medical Eye Evaluation Preferred Practice Pattern(®) Guidelines.

Ophthalmology 2016 Jan 12;123(1):P209-36. Epub 2015 Nov 12.

W.K. Kellogg Eye Center, Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan.

Unlabelled: COMPREHENSIVE ADULT MEDICAL EYE EVALUATION® PREFERRED PRACTICE PATTERN®

Guidelines: Evidence-based update of the Comprehensive Adult Medical Eye Evaluation Preferred Practice Pattern® (PPP) guidelines, discussing the rationale and components of an ophthalmic evaluation for adult patients with and without risk factors. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01616420150126
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http://dx.doi.org/10.1016/j.ophtha.2015.10.047DOI Listing
January 2016
7 Reads

Primary Angle Closure Preferred Practice Pattern(®) Guidelines.

Ophthalmology 2016 Jan 12;123(1):P1-P40. Epub 2015 Nov 12.

Wheaton Eye Clinic, Wheaton, Illinois.

Unlabelled: PRIMARY ANGLE CLOSURE PREFERRED PRACTICE PATTERN®

Guidelines: Evidence-based update of the Primary Angle Closure Preferred Practice Pattern® (PPP) guidelines, describing the diagnosis and management of patients with primary angle closure with detailed recommendations for evaluation and treatment options. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01616420150127
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http://dx.doi.org/10.1016/j.ophtha.2015.10.049DOI Listing
January 2016
11 Reads

Primary Open-Angle Glaucoma Preferred Practice Pattern(®) Guidelines.

Ophthalmology 2016 Jan 12;123(1):P41-P111. Epub 2015 Nov 12.

Wheaton Eye Clinic, Wheaton, Illinois.

Unlabelled: PRIMARY OPEN-ANGLE GLAUCOMA PREFERRED PRACTICE PATTERN®

Guidelines: Evidence-based update of the Primary Open-Angle Glaucoma Preferred Practice Pattern® (PPP) guidelines, describing the diagnosis and management of patients with primary open-angle glaucoma with an algorithm for patient management and detailed recommendations for evaluation and treatment options. Read More

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http://dx.doi.org/10.1016/j.ophtha.2015.10.053DOI Listing
January 2016
11 Reads

Idiopathic Epiretinal Membrane and Vitreomacular Traction Preferred Practice Pattern(®) Guidelines.

Ophthalmology 2016 Jan 12;123(1):P152-81. Epub 2015 Nov 12.

Emory Eye Center, Emory University, Atlanta, Georgia.

Unlabelled: IDIOPATHIC EPIRETINAL MEMBRANE AND VITREOMACULAR TRACTION PREFERRED PRACTICE PATTERN®

Guidelines: New evidence-based Idiopathic Epiretinal Membrane and Vitreomacular Traction Preferred Practice Pattern® (PPP) guidelines, describing recommendations for the diagnosis, treatment, and management of patients. Read More

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http://dx.doi.org/10.1016/j.ophtha.2015.10.048DOI Listing
January 2016
8 Reads

Evidence in Ophthalmology: Are We Doing Better?

Ophthalmology 2015 Dec 4;122(12):2584-6. Epub 2015 Aug 4.

Department of Ophthalmology, Ohio State University, Columbus, Ohio.

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http://dx.doi.org/10.1016/j.ophtha.2015.06.012DOI Listing
December 2015
4 Reads

The Effect of Phacoemulsification on Intraocular Pressure in Glaucoma Patients: A Report by the American Academy of Ophthalmology.

Ophthalmology 2015 Jul 2;122(7):1294-307. Epub 2015 May 2.

Harvard Medical School, Department of Ophthalmology, Massachusetts Eye & Ear Infirmary, Glaucoma Service, Boston, Massachusetts.

Objective: To examine effects of phacoemulsification on longer-term intraocular pressure (IOP) in patients with medically treated primary open-angle glaucoma (POAG; including normal-tension glaucoma), pseudoexfoliation glaucoma (PXG), or primary angle-closure glaucoma (PACG), without prior or concurrent incisional glaucoma surgery.

Methods: PubMed and Cochrane database searches, last conducted in December 2014, yielded 541 unique citations. Panel members reviewed titles and abstracts and selected 86 for further review. Read More

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http://dx.doi.org/10.1016/j.ophtha.2015.03.021DOI Listing
July 2015
25 Reads

Comparison of resident and glaucoma faculty practice patterns in the care of open-angle glaucoma.

BMC Ophthalmol 2015 Apr 14;15:41. Epub 2015 Apr 14.

Wilmer Eye Institute Johns Hopkins University, 600 North Wolfe St. Maumenee B-110, Baltimore, MD, 21287, USA.

Background: Previous studies suggest there are large variations in adherence of ophthalmologists with the American Academy of Ophthalmology's Preferred Practice Patterns (PPPs). The purpose of this study was to compare rates of compliance with glaucoma care guidelines between resident and glaucoma faculty physicians at a single institution.

Methods: Charts of resident continuity clinic or glaucoma faculty patients with primary open angle glaucoma (POAG), ocular hypertension (OHTN), or suspicion of glaucoma were reviewed during the 2005-6 academic year. Read More

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http://dx.doi.org/10.1186/s12886-015-0027-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4403911PMC
April 2015
14 Reads

Update on simulation-based surgical training and assessment in ophthalmology: a systematic review.

Ophthalmology 2015 Jun 10;122(6):1111-1130.e1. Epub 2015 Apr 10.

Centre for Clinical Education, Centre for HR, Capital Region of Denmark, Copenhagen, Denmark.

Topic: This study reviews the evidence behind simulation-based surgical training of ophthalmologists to determine (1) the validity of the reported models and (2) the ability to transfer skills to the operating room.

Clinical Relevance: Simulation-based training is established widely within ophthalmology, although it often lacks a scientific basis for implementation.

Methods: We conducted a systematic review of trials involving simulation-based training or assessment of ophthalmic surgical skills among health professionals. Read More

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http://dx.doi.org/10.1016/j.ophtha.2015.02.028DOI Listing
June 2015
5 Reads

Ocular nutritional supplements: are their ingredients and manufacturers' claims evidence-based?

Ophthalmology 2015 Mar 20;122(3):595-9. Epub 2014 Nov 20.

Section of Ophthalmology, Providence VA Medical Center, Providence, Rhode Island; Division of Ophthalmology, Warren Alpert Medical School of Brown University, Providence, Rhode Island. Electronic address:

Purpose: To compare ingredients contained in top-selling brands of ocular nutritional supplements with the Age-Related Eye Disease Study (AREDS) and AREDS2 formulae and investigate the validity of claims made by manufacturers of leading brands of ocular nutritional supplements.

Design: Descriptive.

Participants: None. Read More

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http://dx.doi.org/10.1016/j.ophtha.2014.09.039DOI Listing
March 2015
11 Reads

Re: Morse et al.: effectively implementing evidence-based medicine (Ophthalmology 2013;120:2163-5).

Authors:
Craig N Czyz

Ophthalmology 2014 Sep 1;121(9):e47-8. Epub 2014 May 1.

Ohio University, Columbus, Ohio.

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http://dx.doi.org/10.1016/j.ophtha.2014.03.033DOI Listing
September 2014
3 Reads

Author reply: To PMID 24182565.

Ophthalmology 2014 Sep 1;121(9):e48. Epub 2014 May 1.

University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.

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http://dx.doi.org/10.1016/j.ophtha.2014.03.034DOI Listing
September 2014
5 Reads

Theoretical and empirical dimensions of the Aberdeen Glaucoma Questionnaire: a cross sectional survey and principal component analysis.

BMC Ophthalmol 2013 Nov 22;13:72. Epub 2013 Nov 22.

Health Services Research Unit, University of Aberdeen, Aberdeen, UK.

Background: To develop patient-reported outcome instruments, statistical techniques (e.g., principal components analysis; PCA) are used to examine correlations among items and identify interrelated item subsets (empirical factors). Read More

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http://bmcophthalmol.biomedcentral.com/articles/10.1186/1471
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http://dx.doi.org/10.1186/1471-2415-13-72DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4222643PMC
November 2013
5 Reads

Evidence-based ophthalmology.

Ophthalmology 2013 Dec;120(12):2361-2363.e1

Director of the US Cochrane Centre and Director of the Clincial Trials Unit at the Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD.

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http://dx.doi.org/10.1016/j.ophtha.2013.08.032DOI Listing
December 2013
5 Reads

Effectively implementing evidence-based medicine.

Ophthalmology 2013 Nov;120(11):2163-5

New York, New York.

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http://dx.doi.org/10.1016/j.ophtha.2013.07.012DOI Listing
November 2013
7 Reads

Evaluation of the anterior chamber angle in glaucoma: a report by the american academy of ophthalmology.

Ophthalmology 2013 Oct 23;120(10):1985-97. Epub 2013 Aug 23.

Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates.

Objective: To assess the published literature pertaining to the association between anterior segment imaging and gonioscopy and to determine whether such imaging aids in the diagnosis of primary angle closure (PAC).

Methods: Literature searches of the PubMed and Cochrane Library databases were last conducted on July 6, 2011. The searches yielded 371 unique citations. Read More

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http://dx.doi.org/10.1016/j.ophtha.2013.05.034DOI Listing
October 2013
9 Reads

Systemic therapies for inflammatory eye disease: past, present and future.

BMC Ophthalmol 2013 Apr 24;13:18. Epub 2013 Apr 24.

Ophthalmology Department, University Hospitals Birmingham NHS Trust, Queen Elizabeth Hospital Birmingham, Mindelsohn Way, Edgbaston, Birmingham, B15 2WB, UK.

In this review we consider the current evidence base for treatments in inflammatory eye disease, and in particular uveitis, from a historical perspective. We consider the challenges that have traditionally hindered progress in inflammatory eye disease including small target populations, heterogeneous disease groups, poorly defined phenotypes, diagnostic inconsistency, subjective outcome measures, specific issues around visual acuity as an outcome measure and low commercial interest. Strategies to address these issues are considered de novo and with reference to recent advances outside of ophthalmology and highlight the promise for ocular inflammation. Read More

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http://dx.doi.org/10.1186/1471-2415-13-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3639939PMC
April 2013
4 Reads

Clinical translation of recommendations from randomized clinical trials on patching regimen for amblyopia.

Ophthalmology 2013 Apr 5;120(4):657-62. Epub 2013 Feb 5.

Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Canada.

Purpose: To investigate whether the evidence-based recommendations by the Pediatric Eye Disease Investigator Group (PEDIG) as initial treatment of amblyopia have been implemented into clinical practice and to discuss the necessary steps in translating evidence-based knowledge to inform clinical decision making.

Design: Retrospective cohort study.

Participants: Children with amblyopia seen from 2007 through 2009 by academic and community ophthalmologists in a large urban center in North America that serves a population of more than 8 million. Read More

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http://dx.doi.org/10.1016/j.ophtha.2012.09.019DOI Listing
April 2013
9 Reads

Clinical classification of age-related macular degeneration.

Ophthalmology 2013 Apr 16;120(4):844-51. Epub 2013 Jan 16.

Division of Epidemiology and Clinical Applications, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892-1204, USA.

Objective: To develop a clinical classification system for age-related macular degeneration (AMD).

Design: Evidence-based investigation, using a modified Delphi process.

Participants: Twenty-six AMD experts, 1 neuro-ophthalmologist, 2 committee chairmen, and 1 methodologist. Read More

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http://dx.doi.org/10.1016/j.ophtha.2012.10.036DOI Listing
April 2013
83 Reads

An evidence-based review of prognostic factors for glaucomatous visual field progression.

Ophthalmology 2013 Mar 1;120(3):512-519. Epub 2012 Dec 1.

University Eye Clinic Maastricht, Maastricht, The Netherlands.

Purpose: To examine which prognostic factors are associated with glaucomatous visual field progression.

Design: Knowledge of prognostic factors helps clinicians to select patients at risk of glaucomatous visual field progression and intensify their treatment.

Methods: By consulting relevant databases, we identified 2733 articles published up to September 2010, of which 85 articles investigating prognostic factors for visual field progression in patients with open-angle glaucoma (OAG) were eligible. Read More

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http://dx.doi.org/10.1016/j.ophtha.2012.09.005DOI Listing
March 2013
5 Reads

Visual acuity improvements after implantation of toric intraocular lenses in cataract patients with astigmatism: a systematic review.

BMC Ophthalmol 2012 Aug 15;12:41. Epub 2012 Aug 15.

Health Economics and Outcomes Research, IMS Health, London, UK.

Background: Cataracts are a common and significant cause of visual impairment globally. We aimed to evaluate uncorrected distance visual acuity (UDVA) as an outcome in treating astigmatic cataract patients to assist clinicians or ophthalmologists in their decision making process regarding available interventions.

Methods: Medline, Embase and Evidence Based Reviews were systematically reviewed to identify relevant studies reporting changes in UDVA, UIVA and UNVA after cataract surgery in presbyopic patients. Read More

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http://dx.doi.org/10.1186/1471-2415-12-41DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3480885PMC
August 2012
4 Reads

Detection of clinically significant retinopathy of prematurity using wide-angle digital retinal photography: a report by the American Academy of Ophthalmology.

Ophthalmology 2012 Jun 27;119(6):1272-80. Epub 2012 Apr 27.

Casey Eye Institute, Oregon Health and Science University, Portland, Oregon, USA.

Objective: To evaluate the accuracy of detecting clinically significant retinopathy of prematurity (ROP) using wide-angle digital retinal photography.

Methods: Literature searches of PubMed and the Cochrane Library databases were conducted last on December 7, 2010, and yielded 414 unique citations. The authors assessed these 414 citations and marked 82 that potentially met the inclusion criteria. Read More

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http://dx.doi.org/10.1016/j.ophtha.2012.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3637992PMC
June 2012
14 Reads

Laser trabeculoplasty for open-angle glaucoma: a report by the american academy of ophthalmology.

Ophthalmology 2011 Nov 17;118(11):2296-302. Epub 2011 Aug 17.

Department of Ophthalmology, Oregon Health and Sciences University, Portland, Oregon, USA.

Objective: To provide an evidence-based summary of the outcomes, repeatability, and safety of laser trabeculoplasty for open-angle glaucoma.

Methods: A search of the peer-reviewed literature in the PubMed and the Cochrane Library databases was conducted in June 2008 and was last repeated in March 2010 with no date or language restrictions. The search yielded 637 unique citations, of which 145 were considered to be of possible clinical relevance for further review and were included in the evidence analysis. Read More

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http://dx.doi.org/10.1016/j.ophtha.2011.04.037DOI Listing
November 2011
36 Reads

Comparative effectiveness and cost-effectiveness of the implantable miniature telescope.

Ophthalmology 2011 Sep 2;118(9):1834-43. Epub 2011 Jul 2.

Center for Value-Based Medicine, Flourtown, Pennsylvania 19031, USA.

Objective: To assess the preference-based comparative effectiveness (human value gain) and the cost-utility (cost-effectiveness) of a telescope prosthesis (implantable miniature telescope) for the treatment of end-stage, age-related macular degeneration (AMD).

Design: A value-based medicine, second-eye model, cost-utility analysis was performed to quantify the comparative effectiveness and cost-effectiveness of therapy with the telescope prosthesis.

Participants: Published, evidence-based data from the IMT002 Study Group clinical trial. Read More

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http://dx.doi.org/10.1016/j.ophtha.2011.02.012DOI Listing
September 2011
29 Reads

A critical appraisal and comparison of the quality and recommendations of glaucoma clinical practice guidelines.

Ophthalmology 2011 Jun 20;118(6):1017-23. Epub 2011 Apr 20.

Department of Ophthalmology, Duke University Eye Center, Durham, North Carolina, USA.

Purpose: To appraise primary open-angle glaucoma (POAG) practice guidelines critically and to compare these guidelines' major recommendations.

Design: Evaluation of clinical practice guidelines and their development process.

Participants: Glaucoma fellowship-trained ophthalmologists. Read More

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http://dx.doi.org/10.1016/j.ophtha.2011.03.038DOI Listing
June 2011
6 Reads

Treatment of Sjögren's syndrome-associated dry eye an evidence-based review.

Ophthalmology 2011 Jul 3;118(7):1242-52. Epub 2011 Apr 3.

The Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Background: Outcomes-based review of reported treatment options for patients with dry eye secondary to Sjögren's syndrome (SS).

Clinical Relevance: Dry eye affects many individuals worldwide. Significant proportion of patients with dry eye has underlying SS, a progressive autoimmune condition. Read More

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http://dx.doi.org/10.1016/j.ophtha.2010.12.016DOI Listing
July 2011
7 Reads

Primary undifferentiated large cell carcinoma of the lacrimal gland.

Ophthalmology 2011 Jun 26;118(6):1189-92. Epub 2011 Jan 26.

Department of Ophthalmology, Ospedale Evangelico Internazionale, Genova, Italy.

Purpose: To report a unique case of primary undifferentiated large cell carcinoma (LCCA) of the lacrimal gland, a tumor not previously described in the ophthalmic literature.

Design: Single interventional case report.

Participants: A patient affected by undifferentiated LCCA of the lacrimal gland. Read More

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http://dx.doi.org/10.1016/j.ophtha.2010.10.039DOI Listing
June 2011
5 Reads

Clinical risk factors for age-related macular degeneration: a systematic review and meta-analysis.

BMC Ophthalmol 2010 Dec 13;10:31. Epub 2010 Dec 13.

Centre for Vision Science, Queen's University Belfast, Northern Ireland, UK.

Background: Age-related macular degeneration (AMD) is the leading cause of blindness in Western countries. Numerous risk factors have been reported but the evidence and strength of association is variable. We aimed to identify those risk factors with strong levels of evidence which could be easily assessed by physicians or ophthalmologists to implement preventive interventions or address current behaviours. Read More

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http://bmcophthalmol.biomedcentral.com/articles/10.1186/1471
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http://dx.doi.org/10.1186/1471-2415-10-31DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3009619PMC
December 2010
11 Reads

Simultaneous mutation detection in 90 retinal disease genes in multiple patients using a custom-designed 300-kb retinal resequencing chip.

Ophthalmology 2011 Jan;118(1):160-167.e1-3

Department of Clinical and Molecular Ophthalmogenetics, Netherlands Institute for Neuroscience, an institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, The Netherlands.

Purpose: To develop a high-throughput, cost-effective diagnostic strategy for the identification of known and new mutations in 90 retinal disease genes.

Design: Evidence-based study.

Participants: Sixty patients with a variety of retinal disorders, including Leber's congenital amaurosis, ocular albinism, pseudoxanthoma elasticum, retinitis pigmentosa, and Stargardt's disease. Read More

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http://dx.doi.org/10.1016/j.ophtha.2010.04.022DOI Listing
January 2011
13 Reads

Corneal neovascularization as a risk factor for graft failure and rejection after keratoplasty: an evidence-based meta-analysis.

Ophthalmology 2010 Jul 3;117(7):1300-5.e7. Epub 2010 Jun 3.

Department of Ophthalmology, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.

Topic: Preoperative corneal neovascularization (CNV) is thought to be associated with an increased rate of corneal graft failure and potentially also graft rejection.

Clinical Relevance: New therapeutic options that offer differential influence on the ingrowths or regression of either corneal blood or lymphatic vessels force us to re-evaluate the known data about the role of CNV in keratoplasty.

Methods: Electronic databases and corneal registries were searched (up through September 2008). Read More

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http://dx.doi.org/10.1016/j.ophtha.2010.01.039DOI Listing
July 2010
5 Reads

Natural history of branch retinal vein occlusion: an evidence-based systematic review.

Ophthalmology 2010 Jun;117(6):1094-1101.e5

Centre for Eye Research Australia, University of Melbourne, VIC, Australia.

Objective: To describe the natural history of branch retinal vein occlusion (BRVO) based on the best available evidence from the literature.

Clinical Relevance: Branch retinal vein occlusion is the second most frequent major retinal vascular disease. Although several new treatments for BRVO are currently being introduced, data on its natural history are sparse. Read More

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http://dx.doi.org/10.1016/j.ophtha.2010.01.058DOI Listing
June 2010
4 Reads

Natural history of central retinal vein occlusion: an evidence-based systematic review.

Ophthalmology 2010 Jun;117(6):1113-1123.e15

Centre for Eye Research Australia, University of Melbourne, VIC, Australia.

Objective: To describe the natural history of central retinal vein occlusion (CRVO) based on the best available evidence from the literature.

Clinical Relevance: Central retinal vein occlusion is a common sight-threatening retinal vascular disease. Despite the introduction of new interventions, the natural history of CRVO is unclear. Read More

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http://dx.doi.org/10.1016/j.ophtha.2010.01.060DOI Listing
June 2010
11 Reads

A proposed method of logarithmic transformation of optical coherence tomography data for use in clinical research.

Ophthalmology 2010 Aug 3;117(8):1512-6. Epub 2010 Apr 3.

National Eye Institute, National Institute of Health, Bethesda, Maryland, USA.

Purpose: To evaluate a logarithmic transformation of retinal thickness measurements from optical coherence tomography as a new approach to assess clinically meaningful changes in retinal thickness.

Design: Methodologic, evidence-based review.

Methods: Standard published approaches for assessing change in retinal thickness over time, as measured by optical coherence tomography (OCT), were compared with a new approach based on a logarithmic transformation of the retinal thickness data. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01616420090141
Publisher Site
http://dx.doi.org/10.1016/j.ophtha.2009.12.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2916055PMC
August 2010
3 Reads