158,133 results match your criteria Evidence-Based Gastroenterology[Journal]


Pembrolizumab for Locally Advanced or Metastatic Urothelial Cancer Where Cisplatin is Unsuitable: An Evidence Review Group Perspective of a NICE Single Technology Appraisal.

Pharmacoeconomics 2018 Dec 13. Epub 2018 Dec 13.

University College London Hospitals NHS Foundation Trust, London, UK.

As part of its Single Technology Appraisal (STA) process, the National Institute for Health and Care Excellence (NICE) invited the manufacturer (Merck Sharp & Dohme) of pembrolizumab (Keytruda) to submit evidence of its clinical and cost effectiveness for the treatment of locally advanced or metastatic urothelial cancer where cisplatin is unsuitable. The School of Health and Related Research Technology Appraisal Group at the University of Sheffield was commissioned to act as the independent Evidence Review Group (ERG). The ERG produced a detailed review of the evidence for the clinical and cost effectiveness of the technology, based on the company's submission (CS) to NICE. Read More

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December 2018

Standardized Cost Estimates for Home Visiting: Pilot Study of the Home Visiting Budget Assistance Tool (HV-BAT).

Matern Child Health J 2018 Dec 13. Epub 2018 Dec 13.

Division of Home Visiting and Early Childhood Systems, HRSA, Maternal and Child Health Bureau, 5600 Fishers Lane, Rockville, MD, 20857, USA.

Purpose Using a standardized approach and metrics to estimate home visiting costs across multiple evidence-based models and regions could improve the consistency and accuracy of cost estimates, allow stakeholders to observe trends in cost allocation, analyze how home visiting costs vary, and develop future program budgets. Between October 2015 and December 2018, we developed and pilot-tested the Home Visiting Budget Assistance Tool (HV-BAT) to standardize the collection of home visiting program costs and analyze costs for local implementing agencies (LIAs). Methods We recruited LIAs that implemented at least one of nine evidence-based home visiting models in 15 states implementing the Maternal, Infant, and Early Childhood Home Visiting (MIECHV) Program. Read More

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December 2018

Age as a Moderator of Social Skills Intervention Response Among Korean Adolescents with Autism Spectrum Disorder.

J Autism Dev Disord 2018 Dec 13. Epub 2018 Dec 13.

Department of Psychiatry, Seoul National University Bundang Hospital, 82, Gumi-ro 173beon-gil, Bundang-gu, Seongnam, Gyeonggi, 13620, South Korea.

Few studies have investigated the effect of age on treatment effectiveness of evidence-based social skills training in autism spectrum disorder (ASD) adolescents. This study evaluated the effectiveness of Program for the Education and Enrichment of Relational Skills (PEERS) in different ages of ASD adolescents. A total of 110 ASD adolescents aged 11-19 years were divided into early, middle, and late adolescence groups, and the changes in outcome measures following intervention were compared among the three groups. Read More

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December 2018

Optimizing medical care for geriatric patients in Austria: defining a top five list of "Choosing Wisely" recommendations using the Delphi technique.

Eur Geriatr Med 2018 27;9(6):783-793. Epub 2018 Sep 27.

14Department of Internal Medicine, Medical University of Graz, Auenbruggerplatz 15, 8036 Graz, Austria.

Purpose: Inappropriate use of diagnostic and therapeutic medical procedures is common and potentially harmful for older patients. The Austrian Society of Geriatrics and Gerontology defined a consensus of five recommendations to avoid overuse of medical interventions and to improve care of geriatric patients.

Methods: From an initial pool of 147 reliable recommendations, 20 were chosen by a structured selection process for inclusion in a Delphi process to define a list of five top recommendations for geriatric medicine. Read More

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September 2018

Surgical strategy for temporal lobe epilepsy with dual pathology and incomplete evidence from EEG and neuroimaging.

Exp Ther Med 2018 Dec 19;16(6):4886-4892. Epub 2018 Sep 19.

Department of Neurosurgery, The Second Hospital of Dalian Medical University, Dalian, Liaoning 116000, P.R. China.

Coexistence of hippocampal sclerosis (HS) and a temporal neocortical lesion, including focal cortical dysplasia, vascular malformations or benign primary brain tumors, is defined as dual pathology. In the majority of cases, the complete evidence based on electroencephalogram (EEG) and magnetic resonance imaging (MRI) for each of the dual pathological lesions is difficult to obtain. As a result, patients with dual pathology are poor surgical candidates due to potential incomplete resection of the epileptogenic zone. Read More

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December 2018

The Effects of Natural Daylight on Length of Hospital Stay.

Environ Health Insights 2018 3;12:1178630218812817. Epub 2018 Dec 3.

Department of Psychiatry, School of Medicine, Ajou University, Suwon, Korea.

Background And Purpose: While providing medical services, hospitals generate many data about patients. Such medical data could contribute to better treatments once their associations or patterns have been identified. With properly analyzed medical data, traditional knowledge at an individual level could be further extended to broader populations. Read More

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December 2018

Health Dynamics in the Built Environment: An Urban Intensity Perspective - An Exploratory Study in Trinidad and Tobago.

Environ Health Insights 2018 29;12:1178630218811342. Epub 2018 Nov 29.

Centre for Environmental Studies and Applied Life Sciences, The University of Trinidad and Tobago, Arima, Trinidad and Tobago.

The built environment encompasses the physical components of the environment, inclusive of infrastructure, households, buildings, streets, and open spaces, within which individuals reside and carry out their daily activities. It affects both indirectly and directly on the outdoor and indoor physical environment as well as the socio-economic environment. The elements which comprise the built environment and those of the physical and socio-economic environments, which are affected by it, are recognised as key determinants of health. Read More

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November 2018

Evidence based or evidence biased!

Authors:
Indu Bhusan Kar

Natl J Maxillofac Surg 2018 Jul-Dec;9(2):115-116

Department of Oral and Maxillofacial Surgery, SCB Dental College and Hospital, Cuttack, Odisha, India. E-mail:

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December 2018

Low back pain.

Nat Rev Dis Primers 2018 Dec 13;4(1):52. Epub 2018 Dec 13.

Center for Health and Medical Psychology, School of Law, Psychology, and Social Work, Örebro University, Örebro, Sweden.

Low back pain affects individuals of all ages and is a leading contributor to disease burden worldwide. Despite advancements in assessment and treatment methods, the management of low back pain remains a challenge for researchers and clinicians alike. One reason for the limited success in identifying effective treatments is the large variation in the manifestations, possible causes, precipitating and maintaining factors, course, prognosis and consequences in terms of activity interference and quality of life. Read More

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December 2018

Variation in Integrated Head and Neck Cancer Care: Impact of Patient and Hospital Characteristics.

J Natl Compr Canc Netw 2018 Dec;16(12):1491-1498

Scientific Center for Quality of Healthcare, and Department of Otolaryngology, Head and Neck Surgery, Radboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen; Department of Otorhinolaryngology, Head and Neck Surgery, Erasmus MC Cancer Institute, Rotterdam; Department of Medical Oncology, Antoni van Leeuwenhoek Nederlands Kanker Instituut, Amsterdam; Department of Oral and Maxillofacial Surgery, Rijnstate Hospital, Arnhem; Department of Oral and Maxillofacial Surgery, Noordwest Ziekenhuisgroep, Alkmaar; Department of Oral and Maxillofacial Surgery, Maastricht University Medical Center, Maastricht; Department of Research, Netherlands Comprehensive Cancer Organisation, Utrecht; Department of Epidemiology, University of Groningen, University Medical Centre Groningen, Groningen; Department of Head and Neck Surgical Oncology, UMC Utrecht Cancer Centre, Utrecht; Department of Radiation Oncology (MAASTRO), GROW - School for Oncology and Developmental Biology, Maastricht University Medical Centre, Maastricht; Department of Oral and Maxillofacial Surgery, Medisch Spectrum Twente, Enschede; Department of Otolaryngology, Head and Neck Surgery, Elisabeth Tweesteden Ziekenhuis Tilburg, Tilburg; Department of Otorhinolaryngology, Head and Neck Surgery, Leiden University Medical Centre, Leiden; Department of Otolaryngology, Head and Neck Surgery, MC Haaglanden-Bronovo, The Hague; Department of Oral and Maxillofacial Surgery, Medical Centre Leeuwarden, Leeuwarden; Department of Otolaryngology, Head and Neck Surgery, VU University Medical Centre, Amsterdam; Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Centre Groningen, Groningen; Department of Head and Neck Surgery and Oncology, Antoni van Leeuwenhoek Nederlands Kanker Instituut, Amsterdam; Department of Oral and Maxillofacial Surgery, Academisch Medisch Centrum, Amsterdam Zuid-Oost; and Department of Oral and Maxillofacial Surgery, Radboud University Medical Centre, Radboud Institute for Health Sciences, Nijmegen, the Netherlands.

Monitoring and effectively improving oncologic integrated care requires dashboard information based on quality registrations. The dashboard includes evidence-based quality indicators (QIs) that measure quality of care. This study aimed to assess the quality of current integrated head and neck cancer care with QIs, the variation between Dutch hospitals, and the influence of patient and hospital characteristics. Read More

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December 2018
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New Cancer Drug Approvals From the Perspective of a Universal Healthcare System: Analyses of the Pan-Canadian Oncology Drug Review Recommendations.

J Natl Compr Canc Netw 2018 Dec;16(12):1460-1466

CancerCare Manitoba, and University of Manitoba, Winnipeg, Manitoba, Canada.

FDA approvals do not consider cost, but they set the tone for regulatory approvals worldwide, including in countries with universal healthcare where cost-effectiveness, utility, and adoption feasibility are considered rigorously. Data from the pan-Canadian Oncology Drug Review (pCODR), a national drug review system that makes evidence-based funding recommendations to Canada's provinces and territories, were collected. Our objectives were to assess (1) temporal trends in cost and efficacy of drugs reviewed, (2) correlations among magnitude of benefits, cost, and pCODR decisions, and (3) predictors of approvals. Read More

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December 2018

Strengthening national vaccine decision-making: Assessing the impact of SIVAC Initiative support on national immunisation technical advisory group (NITAG) functionality in 77 low and middle-income countries.

Vaccine 2018 Dec 10. Epub 2018 Dec 10.

Department of Infectious Disease Epidemiology, Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, Keppel Street, WC1E 7HT London, United Kingdom; Modelling and Economics Unit, Public Health England, 61 Colindale Avenue, NW9 5EQ London, United Kingdom. Electronic address:

Background: National Immunisation Technical Advisory Groups (NITAGs) are multi-disciplinary expert groups that provide policy-makers with independent, evidence-based advice on vaccination. Between 2008 and 2017, the SIVAC Initiative supported establishment and strengthening of NITAGs in low and lower-middle income countries though its impact was never assessed quantitatively.

Aim: To quantitatively assess whether SIVAC support is associated with a faster rate at which NITAGs became functional based on six performance indicators. Read More

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December 2018

A randomized controlled trial assessing the efficacy of a self-administered psycho-educational intervention for patients with cancer.

Patient Educ Couns 2018 Dec 3. Epub 2018 Dec 3.

Louise Granofsky Psychosocial Oncology Program, Segal Cancer Center, Jewish General Hospital, Montreal, Canada; Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Canada; Departments of Psychology, Oncology and Psychiatry, McGill University, Montreal, Canada.

Objective: Bibliotherapy refers to psychological self-help interventions that utilize treatment books to improve psychological well-being. Research supports bibliotherapy as an efficacious intervention for a variety of mental health problems. Yet, few studies have investigated bibliotherapy in psychosocial oncology. Read More

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December 2018

Building a culture of safety in interventional radiology.

Tech Vasc Interv Radiol 2018 Dec 29;21(4):198-204. Epub 2018 Jul 29.

Program Director Vascular Interventional Radiology, University of North Carolina at Chapel Hill, Campus Box 7510, Chapel Hill, NC. Electronic address:

Safety in medicine is a pressing issue. It has been shown that deaths due to medical error range from 98,000 to 400,000 per year in the United States. Since this issue was broached in 1999, a variety of clinical and institutional safety interventions have been pioneered; however, the medical community has realized that without a strong institutional safety culture, the efficacy of these interventions is limited. Read More

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December 2018

Annual review of selected scientific literature: A report of the Committee on Scientific Investigation of the American Academy of Restorative Dentistry.

J Prosthet Dent 2018 Dec;120(6):816-878

Private practice oral and maxillofacial surgery, Ansbach, Bavaria, Germany.

Problem: There are countless numbers of scientific studies published in countless scientific journals on subjects related to restorative dentistry.

Purpose: The purpose of this article is to review pertinent scientific studies published in 2017 on topics of interest to restorative dentists.

Methods And Materials: The authors, considered to be experts in their disciplines searched the scientific literature in 7 different areas (prosthodontics, periodontics, dental materials, occlusion and temporomandibular disorders, sleep-disordered breathing, oral medicine and oral and maxillofacial surgery and dental caries). Read More

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December 2018

The changing landscape of phase II/III metastatic sarcoma clinical trials-analysis of ClinicalTrials.gov.

BMC Cancer 2018 Dec 13;18(1):1251. Epub 2018 Dec 13.

Department of Medical Melanoma and Sarcoma, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, 651 East Dongfeng Road, Guangzhou, 510060, China.

Background: Well-designed clinical trials are of great importance in validating novel treatments and ensuring an evidence-based approach for sarcoma. This study aimed to provide a comprehensive landscape of the characteristics of metastatic or advanced sarcoma clinical trials using the substantial resource of the ClincialTrials.gov database. Read More

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December 2018

Knowledge, perceptions, and clinical experiences on molar incisor hypomineralization among dental care providers in Hong Kong.

BMC Oral Health 2018 Dec 13;18(1):217. Epub 2018 Dec 13.

Paediatric Dentistry, Faculty of Dentistry, The University of Hong Kong, Prince Philip Dental Hospital, 34 Hospital Road, Sai Ying Pun, Hong Kong, SAR, China.

Background: Molar incisor hypomineralization (MIH) is an alarming problem with considerable challenges in management. This study aimed to evaluate and compare the knowledge, perceptions, and clinical experiences of molar incisor hypomineralization (MIH) between general dental practitioners (GDPs) and paediatric dentists (PDs) in Hong Kong.

Methods: A cross-sectional survey of 557 randomly selected GDPs (approximately 25% of all registered dentists) and all registered PDs (n = 31) were invited. Read More

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December 2018

Examining trends in inequality in the use of reproductive health care services in Ghana and Nigeria.

BMC Pregnancy Childbirth 2018 Dec 13;18(1):492. Epub 2018 Dec 13.

Department of Health Services Research, CAPHRI, Maastricht University Medical Center, Faculty of Health, Medicine and Life Sciences, Maastricht University, PO Box 616, 6200MD, Maastricht, The Netherlands.

Background: Equitable use of reproductive health care services is of critical importance since it may affect women's and children's health. Policies to reduce inequality in access to reproductive health care services are often general and frequently benefit the richer population. This is known as the inverse equity situation. Read More

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December 2018

Irish general practitioners' view of perinatal mental health in general practice: a qualitative study.

BMC Fam Pract 2018 Dec 13;19(1):196. Epub 2018 Dec 13.

School of Allied Health, Faculty of Education & Health Sciences, Health Sciences Building, University of Limerick, Limerick, Ireland.

Background: Identification of perinatal mental health problems and effective care for women who experience them are important considering the potentially serious impact that they may have on the wellbeing of the woman, her baby, family and wider society. General practitioners (GPs) play a central role in identifying and supporting women and this study aimed to explore GPs' experiences of caring for women with perinatal mental health problems in primary care. The results of this study may provide guidance to inform policy, practice, research and development of curriculum and continuous professional development resources. Read More

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December 2018

[Irritable bowel syndrome: comorbid psychiatric disorders and psychological treatment options].

Orv Hetil 2018 Dec;159(50):2115-2121

Pszichológiai Intézet, Eötvös Loránd Tudományegyetem Budapest, Izabella u. 46., 1064.

Irritable bowel syndrome is a chronic functional gastrointestinal disorder with a prevalence of 7-21%. It has a negative impact on health-related quality of life and work productivity and it is associated with increased psychological distress and mental comorbidity, like major depression disorder and generalised anxiety disorder. Due to biopsychosocial factors and the brain-gut axis playing a key role in the aetiology of the disease, the use of psychological treatments has great importance in the therapy of irritable bowel syndrome. Read More

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December 2018

Guidelines for the Treatment of PTSD Using Clinical EFT (Emotional Freedom Techniques).

Healthcare (Basel) 2018 Dec 12;6(4). Epub 2018 Dec 12.

School of Psychology, Faculty of Society and Design, Bond University, Robina, Gold Coast, QLD 4229, Australia.

Clinical EFT (Emotional Freedom Techniques) is an evidence-based method that combines acupressure with elements drawn from cognitive and exposure therapies. The approach has been validated in more than 100 clinical trials. Its efficacy for post-traumatic stress disorder (PTSD) has been investigated in a variety of demographic groups including war veterans, victims of sexual violence, the spouses of PTSD sufferers, motor accident survivors, prisoners, hospital patients, adolescents, and survivors of natural and human-caused disasters. Read More

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December 2018

Introduction to the Special Issue on Pediatric Neuro-Oncology.

Bioengineering (Basel) 2018 Dec 11;5(4). Epub 2018 Dec 11.

Department of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

Pediatric Neuro-Oncology is a highly specialized field encompassing molecular biology, clinical acumen, evidence based medicine, cancer genetics and neuropsychological care for the diagnosis and treatment of children with central nervous system (CNS) tumors. [.. Read More

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December 2018

Age-Tastic! An Evaluation of an Evidence-Based Intervention for Older Adults.

Healthcare (Basel) 2018 Dec 8;6(4). Epub 2018 Dec 8.

New York City Department for the Aging, New York, NY 10007, USA.

: Raising awareness of holistic health and safety among older adults is critical to enhancing their wellbeing in many cases, improving health outcomes and motivating positive behavioral changes. Age-Tastic! is a comprehensive health and safety promotion intervention that uses the concept of a competitive board game to entice older adults to participate and stay engaged. : The purpose of this study was to evaluate the impact of Age-Tastic! on the level of awareness, health literacy, self-efficacy and positive behavioral change among the participants. Read More

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December 2018

Rhabdomyosarcoma and Extraosseous Ewing Sarcoma.

Children (Basel) 2018 Dec 10;5(12). Epub 2018 Dec 10.

Cincinnati Children's Hospital Medical Center, Division of Pediatric General and Thoracic Surgery, Cincinnati, OH 45229, USA.

Rhabdomyosarcoma (RMS) is a malignant tumor that represents the most common form of pediatric soft tissue sarcoma. It arises from mesenchymal origin and forms part of the group of small round blue cell tumors of childhood. It has a constant annual incidence of 4. Read More

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December 2018

Treatment of Pain in Cancer: Towards Personalised Medicine.

Cancers (Basel) 2018 Dec 10;10(12). Epub 2018 Dec 10.

Department of Anesthesiology and Pain Management, Maastricht University Medical Centre (MUMC+), University Pain Centre Maastricht (UPCM), 6229HX Maastricht, The Netherlands.

Despite increased attention to cancer pain, pain prevalence in patients with cancer has not improved over the last decade and one third of cancer patients on anticancer therapy and half of patients with advanced disease still suffer from moderate to severe pain. In this review, we explore the possible reasons for the ongoing high prevalence of cancer pain and discuss possible future directions for improvement in personalised pain management. Among possible reasons for the lack of improvement are: Barriers for patients to discuss pain with clinicians spontaneously; pain measurement instruments are not routinely used in daily practice; limited knowledge concerning the assessment of undertreatment; changes in patients' characteristics, including the ageing of the population; lack of significant improvement in the treatment of neuropathic pain; limitations of pharmacological treatment and lack of evidence-based nonpharmacological treatment strategies. Read More

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December 2018

Delivery of Fall Prevention Interventions for At-Risk Older Adults in Rural Areas: Findings from a National Dissemination.

Int J Environ Res Public Health 2018 Dec 10;15(12). Epub 2018 Dec 10.

Administration for Community Living, Washington, DC 20201, USA.

Falls incidence rates and associated injuries are projected to increase among rural-dwelling older adults, which highlights the need for effective interventions to prevent falls and manage fall-related risks. The purpose of this descriptive study was to identify the geospatial dissemination of eight evidence-based fall prevention programs (e.g. Read More

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December 2018

Fascia iliaca compartment block versus intravenous analgesic for positioning of femur fracture patients before a spinal block: A PRISMA-compliant meta-analysis.

Medicine (Baltimore) 2018 Dec;97(49):e13502

Graduate Institute of Clinical Medicine.

Background: Fascia iliaca compartment block (FICB) provides an analgesic option for positioning before spinal anesthesia in patients suffering from a femur fracture. The evidence supporting FICB is still not well established. The aim of our study is to assess the efficacy and safety of FICB comparing with intravenous analgesic (IVA) on the quality for positioning before spinal anesthesia in participants with a femur fracture. Read More

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December 2018

Continuum of the United States military's traumatic brain injury care: adjusting to the changing battlefield.

Authors:

Neurosurg Focus 2018 Dec;45(6):E15

Over the past 8 years, advances in the US Military Health System (MHS) have led to extensive changes in the way combat casualty care is provided to deployed service members with a traumatic brain injury (TBI). Changes include the application of cutting-edge Clinical Practice Guidelines, use of pioneering technologies, and advances in evacuation procedures. Compared with previous engagements, current operations occur on a much smaller scale, and more frequently in austere environments, such that effective medical support is increasingly challenging. Read More

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December 2018

Nintedanib in Idiopathic Pulmonary Fibrosis: Practical Management Recommendations for Potential Adverse Events.

Respiration 2018 Dec 13:1-12. Epub 2018 Dec 13.

Department of Pulmonary Disease, Erasmus Medical Centre, University Hospital Rotterdam, Rotterdam, The Netherlands.

Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease with a dismal survival rate of only 3 years and no curative pharmacological therapy. The recent approval of 2 anti-fibrotic drugs (nintedanib and pirfenidone) that slow disease progression has provided some hope for patients. However, effectively managing anti-fibrotic treatment can be a challenge due to tolerability issues, the presence of pulmonary and extra-pulmonary comorbidities, and the need for concomitant medications in many patients. Read More

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December 2018

Assessing nursing students' knowledge of evidence-based guidelines on the management of peripheral venous catheters: A multicentre cross-sectional study.

Nurse Educ Today 2018 Dec 7;73:77-82. Epub 2018 Dec 7.

Department of Medicine and Aging Sciences, University of Chieti-Pescara, Italy; ASL 02 Abruzzo, Chieti, Italy. Electronic address:

Background: Inserting Peripheral Venous Catheters (PVCs) is one of the most routinely performed invasive procedures in nursing care and, if not well managed, it could expose patients to bloodstream-related infections. Knowledge of guidelines for the management of PVCs is fundamental to arise nurses and nursing students (NSs)' awareness on the importance of recommendations' adherence for clinical practice improvement.

Objective: To determine NSs' theoretical knowledge of evidence-based guidelines for management of PVCs and investigate potential predictive factors associated to recommendations' adherence. Read More

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December 2018

Student acceptance of e-learning methods in the laboratory class in Optometry.

PLoS One 2018 13;13(12):e0209004. Epub 2018 Dec 13.

School of Optometry and Vision Science, University of Auckland, Auckland, New Zealand.

Today's students have increased expectations for flexible learning options and evidence-based practice resources to be available to support curricular activities. We investigated: (i) the suitability of a static website for teaching ocular anatomy and physiology and an interactive version of the website with quiz and self-assessment activities and (ii) the usefulness of a blended online and in-lab environment to teach in Optometry. We administered a survey to compare responses of optometry students who had access to the interactive website, with those from students from a previous year who used the static version. Read More

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December 2018

Facility Design: Reimagining Approaches to Childbirth in Hospital and Birth Center Settings.

J Perinat Neonatal Nurs 2018 Dec 12. Epub 2018 Dec 12.

Grow Midwives, LLC, Shawnee, Kansas.

Few maternity care clinicians are aware of the current regulations that guide design standards for childbirth facilities in the United States or the regulatory history. There is considerable variance among state regulations as well as oversight of facility standards for healthcare settings. Understanding evidence-based recommendations on how facility design affects health outcomes is critical to reversing the rise in maternal mortality and morbidity. Read More

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December 2018

Strategies to improve antibiotic use in the neonatal ICU.

Curr Opin Pediatr 2018 Dec 12. Epub 2018 Dec 12.

Division of Pediatric Infectious Diseases, Department of Pediatrics, University of California Los Angeles, Los Angeles, California, USA.

Purpose Of Review: Neonates are at a high risk of infection and may have nonspecific signs of sepsis. Accordingly, they are heavily exposed to antimicrobials. Neonates are also uniquely at risk of both short-term and long-term complications from antibiotic exposure. Read More

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December 2018

Preserving Optimal Cardiovascular Health in Children.

Pediatr Ann 2018 Dec;47(12):e479-e486

The origins of cardiovascular disease are at the beginning of life, and national guidelines recommend evaluation for cardiovascular risk factors such as obesity and hypertension as part of general pediatric care. In this review, a simple plan is proposed for clear and consistent monitoring and messaging throughout childhood, based on the American Heart Association's "cardiovascular health" construct. A framework is provided for age-appropriate scoring of the cardiovascular health components, including diet, physical activity and screen time, sleep, smoking exposure, body mass index, blood pressure, cholesterol, and glucose. Read More

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December 2018

De-prescribing benzodiazepine receptor agonists taken for insomnia: a review and key messages from practice guidelines.

Pol Arch Intern Med 2018 Dec 13. Epub 2018 Dec 13.

Long term benzodiazepine receptor agonist (BZRA) use for insomnia is common and highly prevalent in adults in all care settings. Evidence syntheses suggest that the therapeutics benefits of benzodiazepines for insomnia are marginal and very short term. On the harm side, BZRAs are associated with daytime sedation and confusion. Read More

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December 2018

The evidence-based approach for surgical complications in the treatment of lumbar disc herniation.

Int Orthop 2018 Dec 12. Epub 2018 Dec 12.

Department of Orthopedic Surgery, University of California Davis, 4860 Y Street Suite 3700, Sacramento, CA, 95817, USA.

Purpose: The purpose of this article is to review the evidence-based approach for surgical complications following disc herniation.

Methods: A search of the primary English literature was conducted for research examining the outcomes and complications of surgical discectomy. Special regard was given to high-quality prospective randomized studies. Read More

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December 2018

Standardized Practice Reduces Complications in Breast Augmentation: Results with the First 290 Consecutive Cases Versus Non-standardized Comparators.

Aesthetic Plast Surg 2018 Dec 12. Epub 2018 Dec 12.

Plastic Surgery, Health Park, Via Michelangelo Schipa 40, 80122, Naples, Italy.

Background: Several systematic methods for breast augmentation have been published, providing key principles and technical steps for minimizing complications and optimizing patient satisfaction. The aim of this study was to compare complication rates in patients receiving a breast augmentation performed using a structured, standardized approach versus comparator patients operated on without a standardized approach.

Methods: This was a single-center, retrospective review of 290 consecutive breast augmentations performed between October 2016 and September 2017 based on a standardized technique (Randquist's "five P's" combined with Adams' 14-point plan), and 235 comparators who underwent breast augmentations prior to standardization between April 2014 and September 2016. Read More

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December 2018

Effects of Hat-Shaped Mortised Genioplasty with Genioglossus Muscle Advancement on Retrogenia and Snoring: Assessment of Esthetic, Functional, and Psychosocial Results.

Aesthetic Plast Surg 2018 Dec 12. Epub 2018 Dec 12.

Department of Plastic and Reconstructive Surgery, Institute for Human Tissue Restoration, Gangnam Severance Hospital, Yonsei University College of Medicine, 211 Eonju-ro, Gangnam-gu, Seoul, 06273, Republic of Korea.

Background: An increasing number of patients undergo genioplasty for esthetic purposes to correct micrognathism or retrognathism. However, these conditions are considered an important risk factor for snoring. The purpose of this study was to evaluate both esthetic improvement and functional changes of snoring symptoms in patients who underwent hat-shaped mortised advancing genioplasty with genioglossus muscle advancement. Read More

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December 2018

Attitudes Towards Evidence-Based Practice in Substance Use Treatment Programs Serving American Indian Native Communities.

J Behav Health Serv Res 2018 Dec 12. Epub 2018 Dec 12.

Child and Adolescent Research Centre, San Diego, USA.

The objective of this paper was to compare attitudes towards evidence-based practice (EBP) of substance use disorder treatment (SUDT) center employees' serving American Indian and Alaskan Native (AIAN) populations to those serving non-AIAN populations. Survey data on the openness and divergence subscales of the Evidence-Based Practice Attitude Scale (EBPAS) were collected and analyzed. Independent samples T tests were performed to compare the two samples. Read More

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December 2018

The Temporal Relationship Between Medicaid Payment Acceptance and the Implementation of Medication-Assisted Drug Treatment.

Subst Abuse 2018 12;12:1178221818811314. Epub 2018 Nov 12.

Suzanne Dworak-Peck School of Social Work and Marshall School of Business, University of Southern California, Los Angeles, CA, USA.

Objective: To examine the temporal relationship of Medicaid funding on the implementation of evidence-based practices (EBPs) in outpatient substance use disorder (SUD) treatment.

Methods: We examined data from 61 publicly funded SUD treatment programs in 2011 and 2013 using crossed-lagged regressions. We tested the impact of Medicaid payment acceptance on 2 measures of EBP implementation-contingency management treatment (CMT) and medication-assisted treatment (MAT). Read More

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November 2018

Assessment of HDL Cholesterol Removal Capacity: Toward Clinical Application.

Authors:
Ryuji Toh

J Atheroscler Thromb 2018 Dec 12. Epub 2018 Dec 12.

Division of Evidence-based Laboratory Medicine, Kobe University Graduate School of Medicine.

While there is a controversy regarding the causal relationship between high-density lipoprotein cholesterol (HDL-C) and cardiovascular disease (CVD), recent studies have demonstrated that the cholesterol efflux capacity (CEC) of HDL is associated with the incidence of CVD. However, there are several limitations to current assays of CEC. First, CEC measurements are not instantly applicable in clinical settings, because CEC assay methods require radiolabeled cholesterol and cultured cells, and these procedures are time consuming. Read More

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December 2018

Metagenomic Discovery of 83 New Human Papillomavirus Types in Patients with Immunodeficiency.

mSphere 2018 Dec 12;3(6). Epub 2018 Dec 12.

Laboratory of Cellular Oncology, National Cancer Institute, Bethesda, Maryland, USA.

Several immunodeficiencies are associated with high susceptibility to persistent and progressive human papillomavirus (HPV) infection leading to a wide range of cutaneous and mucosal lesions. However, the HPV types most commonly associated with such clinical manifestations in these patients have not been systematically defined. Here, we used virion enrichment, rolling circle amplification, and deep sequencing to identify circular DNA viruses present in skin swabs and/or wart biopsy samples from 48 patients with rare genetic immunodeficiencies, including patients with warts, hypogammaglobulinemia, infections, myelokathexis (WHIM) syndrome, or epidermodysplasia verruciformis (EV). Read More

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December 2018

Dealing with the gray zones in the management of gastric cancer: The consensus statement of the İstanbul Group.

Turk J Gastroenterol 2018 Dec 12. Epub 2018 Dec 12.

Koç University School of Medicine, İstanbul, Turkey.

The geographical location and differences in tumor biology significantly change the management of gastric cancer. The prevalence of gastric cancer ranks fifth and sixth among men and women, respectively, in Turkey. The international guidelines from the Eastern and Western countries fail to manage a considerable amount of inconclusive issues in the management of gastric cancer. Read More

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December 2018

Optimal timing for inguinal hernia repair in premature infants: a systematic review and meta-analysis.

J Pediatr Surg 2018 Nov 14. Epub 2018 Nov 14.

Faculty of Medicine, University of Ottawa, 451 Smyth Rd, Ottawa, ON, Canada, K1H 8M5; Department of Pediatric Surgery, Children's Hospital of Eastern Ontario, 401 Smyth Road, Ottawa, ON, Canada, K1H 8L1. Electronic address:

Background: The optimal timing of repair for inguinal hernia in premature infants remains a controversial topic. Our objective was to assess the clinical effects of inguinal hernia repair done before or after neonatal intensive care unit (NICU) discharge.

Methods: MEDLINE, Embase, CINAHL, and CENTRAL were searched in July 2018. Read More

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November 2018

[Visualization studies on research status of the ventilator-associated pneumonia based on SinoMed database].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2018 Nov;30(11):1029-1035

Department of Critical Care Medicine, Gansu Provincial People's Hospital, Lanzhou 730000, Gansu, China (Zhao J, Zhang LQ, Zhang DQ, Yuan Y); Gansu University of Traditional Chinese Medicine, Lanzhou 730000, Gansu, China (Zhao J, He TP, Gong D); Evidence-Based Medicine Center of Lanzhou University, Lanzhou 730000, Gansu, China (Tian JH). Corresponding author: Yuan Yuan, Email:

Objective: To survey the distribution pattern and subject domain knowledge of the literatures about ventilator-associated pneumonia (VAP).

Methods: Literatures about VAP published until December 2017 were identified in SinoMed database for statistics and analysis. The information of author, organization and province was extracted by BICOMS software for generating co-occurrence matrix, at the same time, the topic words were cluster analyzed by Gcluto software to generate topical visual surface maps and visualization matrices, and the current research hotspots were analyzed. Read More

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November 2018

Supporting breast cancer screening decisions for caregivers of older women with dementia: study protocol for a randomized controlled trial.

Trials 2018 Dec 12;19(1):678. Epub 2018 Dec 12.

Indiana University School of Medicine, 1101 West 10th Street, Indianapolis, IN, 46202, USA.

Background: Alzheimer's disease and related dementias (ADRD) impact a woman's life expectancy and her ability to participate in medical decision-making about breast cancer screening, necessitating the involvement of family caregivers. Making decisions about mammography screening for women with ADRD is stressful. There are no data that suggest that breast cancer screening helps women with ADRD live longer or better. Read More

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December 2018

Middle managers' role in implementing evidence-based practices in healthcare: a systematic review.

Implement Sci 2018 Dec 12;13(1):149. Epub 2018 Dec 12.

Center for Healthcare Organization and Implementation Research (CHOIR), VA Boston Healthcare System, 150 South Huntington Avenue (152M), Jamaica Plain Campus, Building 9, Boston, MA, 02130, USA.

Background: Middle managers are in a unique position to promote the implementation of evidence-based practices (EBPs) in healthcare organizations, yet knowledge of middle managers' role in implementation and determinants (e.g., individual-, organizational-, and system-level factors) which influence their role remains fractured, spanning decades and disciplines. Read More

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December 2018

German language questionnaires for assessing implementation constructs and outcomes of psychosocial and health-related interventions: a systematic review.

Implement Sci 2018 Dec 12;13(1):150. Epub 2018 Dec 12.

Department for Evidence-based Medicine and Clinical Epidemiology, Danube-University Krems, Dr.-Karl-Dorrek Strasse 30, 3500, Krems a.d. Donau, Austria.

Background: Over the past years, implementation science has gained more and more importance in German-speaking countries. Reliable and valid questionnaires are needed for evaluating the implementation of evidence-based practices. On an international level, several initiatives focused on the identification of questionnaires used in English-speaking countries but limited their search processes to mental health and public health settings. Read More

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December 2018