50,295 results match your criteria Evaluation of Gestation


Is there a safety signal for dolutegravir and integrase inhibitors during pregnancy?

J Acquir Immune Defic Syndr 2019 Apr 19. Epub 2019 Apr 19.

Assistance Publique-Hopitaux de Paris, Hopitaux Universitaires Paris Centre, Centre Régional de Pharmacovigilance. 27 rue du Faubourg Saint-Jacques, 75014 Paris, France.

Background: Dolutegravir, an integrase strand transfer inhibitor (InSTI) is a major antiretroviral agent for HIV infection. Its use is promising, especially in low and middle-income countries, because of a high resistance barrier and a good safety profile. Very recently, a WHO safety signal has been raised regarding neural tube defects after first trimester exposure. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/QAI.0000000000002065DOI Listing

Evaluation of the effectiveness and usability of an educational portion size tool, ServARpreg, for pregnant women.

J Hum Nutr Diet 2019 Apr 24. Epub 2019 Apr 24.

School of Health Sciences, Faculty of Health and Medicine, The University of Newcastle, Callaghan, NSW, Australia.

Background: Elevated blood glucose levels in pregnancy increases the risk of adverse pregnancy outcomes. Modifying consumption of carbohydrate-rich foods is important for blood glucose regulation; however, the tools commonly used to assist in guiding portion control are impractical. The present study aimed to evaluate usability of ServARpreg, a mobile phone-based nutrition tool, and its effectiveness with respect to improving carbohydrate and standard serve size knowledge in pregnant women. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jhn.12660DOI Listing

Evaluation and Management of Congenital Chagas Disease in the United States.

J Pediatric Infect Dis Soc 2019 Apr 24. Epub 2019 Apr 24.

Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, Georgia.

Chagas disease is underappreciated as a health concern in the United States. Approximately 40 000 women of childbearing age living in the United States have chronic Chagas disease. Most of them are unaware that they have an infection that is transmissible to their offspring. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/jpids/piz018DOI Listing

A Case of Dubin-Johnson Syndrome in Pregnancy.

Cureus 2019 Feb 11;11(2):e4048. Epub 2019 Feb 11.

Obstetrics & Gynecology, Maulana Azad Medical College, New Delhi, IND.

Dubin-Johnson syndrome is an autosomal recessive condition characterized by recurrent episodes of jaundice and conjugated hyperbilirubinemia. It exacerbates during pregnancy and needs to be differentiated from other causes of jaundice. A 30-year-old patient presented to us with jaundice in her fourth pregnancy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7759/cureus.4048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6464460PMC
February 2019

Immunization in pregnancy safety surveillance in low and middle-income countries- field performance and validation of novel case definitions.

Vaccine 2019 Apr 20. Epub 2019 Apr 20.

Medical Research Council: Respiratory and Meningeal Pathogens Research Unit, Department of Science and Technology/National Research Foundation: Vaccine Preventable Diseases, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; African Leadership in Vaccinology Expertise (ALIVE), Faculty of Health Science, University of the Witwatersrand, South Africa.

Background: A globally standardized approach in high and low and middle-income countries (LMIC) to actively monitor the safety of vaccines for pregnant women during development and implementation phases is critical. Brighton Collaboration's (BC) Global Alignment of Immunization Safety Assessment in Pregnancy (GAIA) project has developed globally standardized case definitions (CDs) of key obstetric and neonatal terms for the assessment of safety of vaccines in pregnancy. CDs are categorized into levels of diagnostic certainty, facilitating their use in varied settings. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S0264410X193042
Publisher Site
http://dx.doi.org/10.1016/j.vaccine.2019.03.074DOI Listing
April 2019
1 Read

The evaluation of embryotoxicity of Ligusticum chuanxiong on mice and embryonic stem cells.

J Ethnopharmacol 2019 Apr 20:111895. Epub 2019 Apr 20.

Guangzhou University of Chinese Medicine, School of Pharmaceutical Sciences, Guangzhou, 511400, China. Electronic address:

Ethnopharmacological Relevance: Chuanxiong (Chuanxiong Rhizoma, CR), the dried rhizome of Ligusticum chuanxiong Hort, has been used during pregnancy for more than 2000 years. However, the embryotoxicity of CR was not evaluated so far. The purpose of this study was to examine the safety and rational use of CR during pregnancy on mice and mouse embryonic stem cell (ES), and to explore the mechanism of embryotoxicity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jep.2019.111895DOI Listing

[Association of exposure to polycyclic aromatic hydrocarbons during pregnancy with autism spectrum disorder-related behaviors in toddlers: a birth cohort study].

Zhongguo Dang Dai Er Ke Za Zhi 2019 Apr;21(4):332-336

Qingdao University, Qingdao, Shandong 266071, China.

Objective: To study the association of exposure to polycyclic aromatic hydrocarbons (PAH) during pregnancy and autism spectrum disorder (ASD)-related behaviors in toddlers.

Methods: A total of 348 toddlers who had accepted the measurement of PAH-DNA adduct in umbilical cord blood and evaluation of behavior problems at the age of 36 months were enrolled in this birth cohort study. Child Behavior Checklist (CBCL) and Autism Behavior Checklist (ABC) were used to evaluate behavior problems at the age of 36 months. Read More

View Article

Download full-text PDF

Source

Feasibility and Acceptability of 'Opt-In' Referrals for Stop Smoking Support in Pregnancy.

Int J Environ Res Public Health 2019 Apr 16;16(8). Epub 2019 Apr 16.

Division of Primary Care, University of Nottingham, Tower Building, University Park, Nottingham NG7 2RD, UK.

Background: International guidelines recommend that following an early-pregnancy 'opt-out' referral for smoking cessation support, pregnant women who smoke should also be offered referrals at subsequent antenatal appointments ('opt-in' referrals). We assessed feasibility and acceptability of introducing 'opt-in' self-referral forms to stop smoking services (SSS) in antenatal clinics.

Method: A 'before-after' service evaluation and qualitative interviews. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijerph16081358DOI Listing

Surface Body Temperature of Full-Term Healthy Newborns Immediately after Birth-Pilot Study.

Int J Environ Res Public Health 2019 Apr 12;16(8). Epub 2019 Apr 12.

Department of Functional Anatomy and Biometry, Faculty of Physical Education and Health Promotion, University of Szczecin, al. Piastów 40b/6, 71-065 Szczecin, Poland.

The aim of the study was to perform an evaluation of chosen body surface temperatures in neonates immediately after birth, and to seek a relationship between those temperatures and the factors related both to the mother and newborn. The study included 74 healthy newborns. Maternal age, body weight, body mass index before pregnancy and on delivery day, birth and pregnancy order, newborn sex, birth weight, body length, pregnancy week on delivery, as well as newborn gasometric test results were collected. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijerph16081312DOI Listing

Evaluation of the indirect and IgM-capture anti-human cytomegalovirus (CMV) IgM ELISA methods as confirmed by CMV IgG avidity.

Microbiol Immunol 2019 Apr 23. Epub 2019 Apr 23.

Department of Microbiology, Fukushima Medical University School of Medicine, Fukushima.

Primary cytomegalovirus (CMV) infection during pregnancy often results in congenital CMV infection with severe clinical complications. IgM antibodies are one of the indices of primary infection. IgG avidity index (AI) is also known to remain low for 3 months from primary infection. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/1348-0421.12683DOI Listing

Development of a pharmacist-provided contraceptive service following passage of Oregon House Bill 2879.

J Am Pharm Assoc (2003) 2019 Apr 19. Epub 2019 Apr 19.

Objectives: To describe the development and implementation of a pharmacist-provided contraceptive service in a community pharmacy to increase access to hormonal contraceptives and improve quality measure performance following passage of Oregon House Bill 2879.

Setting: Community pharmacy embedded within a federally qualified health center (FQHC).

Practice Description: Not applicable. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.japh.2019.02.014DOI Listing

European Stroke Organization guideline for the diagnosis and treatment of cerebral venous thrombosis - Endorsed by the European Academy of Neurology.

Eur Stroke J 2017 Sep 21;2(3):195-221. Epub 2017 Jul 21.

Department of Neurology, Academic Medical Center, Amsterdam, the Netherlands.

The current proposal for cerebral venous thrombosis guideline followed the Grading of Recommendations, Assessment, Development, and Evaluation system, formulating relevant diagnostic and treatment questions, performing systematic reviews of all available evidence and writing recommendations and deciding on their strength on an explicit and transparent manner, based on the quality of available scientific evidence. The guideline addresses both diagnostic and therapeutic topics. We suggest using magnetic resonance or computed tomography angiography for confirming the diagnosis of cerebral venous thrombosis and not screening patients with cerebral venous thrombosis routinely for thrombophilia or cancer. Read More

View Article

Download full-text PDF

Source
http://journals.sagepub.com/doi/10.1177/2396987317719364
Publisher Site
http://dx.doi.org/10.1177/2396987317719364DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454824PMC
September 2017
1 Read

Clinical and ultrasonographic parameters in assessment of labor induction success in nulliparous women.

J Matern Fetal Neonatal Med 2019 Apr 21:1-8. Epub 2019 Apr 21.

a Clinic of Obstetrics and Gynecology , Clinical Center of Serbia , Belgrade , Serbia.

Purpose: Evaluation of simplified Bishop score and ultrasound cervicometry in the assessment of labor induction success in nulliparous women.

Methods: Prospective cohort study included 146 nulliparous women with singleton pregnancy and indications for labor induction. Prior to labor induction, cervicometry and Bishop score were determined. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/14767058.2019.1
Publisher Site
http://dx.doi.org/10.1080/14767058.2019.1594185DOI Listing
April 2019
1 Read

Melanonychia striata: clarifying behind the Black Curtain. A review on clinical evaluation and management of the 21st century.

Int J Dermatol 2019 Apr 21. Epub 2019 Apr 21.

Departments of Pediatrics, Laboratory Medicine, and Pathology, The University of Alberta, Edmonton, Alberta, Canada.

Melanonychia striata is characterized by a tan, brown, or black longitudinal streak within the nail plate that runs from the proximal nail fold to the distal part of the nail plate. Melanonychia striata is due to increased activity of melanocytes or melanocytic hyperplasia in the nail matrix with subsequently increased melanin deposition in the nail plate. The most common cause of melanonychia striata associated with melanocytic activation is ethnic melanonychia which occurs in dark-skinned individuals. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/ijd.14464
Publisher Site
http://dx.doi.org/10.1111/ijd.14464DOI Listing
April 2019
4 Reads

Multi-center evaluation of oxidation-reduction potential by the MiOXSYS in males with abnormal semen.

Asian J Androl 2019 Apr 16. Epub 2019 Apr 16.

Tulane University, New Orleans, LA 70118, USA.

According to the World Health Organization (WHO), oxidative stress (OS) is a significant contributor to male infertility. Seminal OS can be measured by a number of assays, all of which are either costly or time sensitive and/or require large semen volume and complex instrumentation. One less expensive alternative is to quantify the oxidation-reduction potential (ORP) with the MiOXSYS. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/aja.aja_5_19DOI Listing

A review of reproductive outcomes of women with two consecutive miscarriages and no living child.

J Obstet Gynaecol 2019 Apr 22:1-6. Epub 2019 Apr 22.

a Department of Obstetrics and Gynaecology , University College Cork , Cork , Ireland.

The definition of recurrent miscarriage ranges from two miscarriages according to the American Society for Reproductive Medicine and the European Society of Human Reproduction and Embryology, to three consecutive pregnancy losses as defined by the Royal College of Obstetricians and Gynaecologists. Recent guidelines emphasise the need for further research on the effect of various recurrent miscarriage definitions on diagnosis, treatment and prognosis. Our study examines the management and pregnancy outcomes of nulliparous women attending Cork University Maternity Hospital's Pregnancy Loss Clinic, between 2009 and 2014, with their second consecutive first-trimester miscarriage. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/01443615.2019.1
Publisher Site
http://dx.doi.org/10.1080/01443615.2019.1576600DOI Listing
April 2019
1 Read

[Value of anti-Müllerian hormone and age in predicting pregnancy outcomes of in vitro fertilization and embryo transfer treatment].

Zhonghua Fu Chan Ke Za Zhi 2019 Apr;54(4):239-244

Reproductive Medical Center, Henan Provincial People's Hospital, Zhengzhou 450003, China.

To explore the value of anti-Müllerian hormone (AMH) and age in predicting outcomes of patients undergoing in vitro fertilization and embryo transfer treatment. In this retrospective study, 6 328 Chinese patients who underwent the first in vitro fertilization or intracytoplasmic sperm injection and embryo transfer treatment in Henan Provincial Peoples Hospital between July 2016 and July 2018 were analyzed. All the patients were categorized into two groups according to pregnancy or not. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3760/cma.j.issn.0529-567x.2019.04.005DOI Listing

Clomiphene citrate and neural tube defects: a meta-analysis of controlled observational studies.

BJOG 2019 Apr 21. Epub 2019 Apr 21.

Service Hospitalo-Universitaire de Pharmaco-Toxicologie, Hospices Civils de Lyon, France.

Background: At the end of the 80's several studies have suggested a potential increased risk of neural tube defects (NTDs) with ovulation induction/fertility drugs, especially with clomiphene citrate (CC). A previous meta-analysis of observational studies evaluating the risk of NTDs associated with the use of CC performed in 1995 found a risk ratio of 1.08 (95% confidence intervals (CI) 0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/1471-0528.15800DOI Listing
April 2019
1 Read

Teratogenic potential of third-generation antiepileptic drugs: Current status and research needs.

Pharmacol Rep 2019 Jan 31;71(3):491-502. Epub 2019 Jan 31.

Neurobiology Lab, Department of Zoology, University of Allahabad, Allahabad, India. Electronic address:

The aim of this review was to scrutinize the current literature available on teratogenic safety of third-generation antiepileptic drugs (TGAEDs) considering their clinical implications and to highlight for further research need in the interest of the diseased population in general and women with epilepsy in particular. For evaluation of the teratogenic potential of TGAEDs, this review summarized the existing information on controlled clinical trials conducted by the pharmaceutical companies, case reports, scholarly articles (prospective and retrospective studies), and experimental tests carried out so far. Firstly, clinical reports have reviewed on each drug followed by non-clinical studies reported hitherto. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.pharep.2019.01.011DOI Listing
January 2019

Effect of postpartum glucose tolerance results on subsequent weight retention in women with recent gestational diabetes: a retrospective cohort study.

Diabetes Res Clin Pract 2019 Apr 17. Epub 2019 Apr 17.

Women's College Research Institute, Women's College Hospital, Toronto, Canada; Institute of Health Policy, Management and Evaluation/Dalla Lana School of Public Health, University of Toronto, Toronto, Canada; Department of Medicine, University of Toronto, Toronto, Canada; Institute for Clinical Evaluative Sciences, Toronto, Canada; Sunnybrook Health Sciences Centre, Toronto, Canada. Electronic address:

Aims: Glucose tolerance normalizes postpartum in most women with gestational diabetes (GDM), which may provide false reassurance and decrease weight-reducing behaviours. We evaluated whether awareness of normal postpartum glucose tolerance was associated with higher weight retention than being unaware of glucose tolerance.

Methods: This cohort study of women with GDM collected survey data during pregnancy and in the first and second postpartum year. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01688227193013
Publisher Site
http://dx.doi.org/10.1016/j.diabres.2019.04.016DOI Listing
April 2019
5 Reads

Preconception Care in the Veterans Health Administration.

Semin Reprod Med 2018 Nov 19;36(6):327-339. Epub 2019 Apr 19.

VA Central Office, Women's Health Services, Washington, District of Columbia.

Preconception care (PCC), defined as a set of interventions to help women optimize their health and well-being prior to pregnancy, can improve pregnancy outcomes and is recommended by national organizations including the Centers for Disease Control and Prevention and the American College of Obstetricians and Gynecologists. Women Veterans who use the Department of Veterans Affairs (VA) health care system may face elevated risks of adverse pregnancy and birth outcomes due to a high prevalence of chronic medical and mental health conditions as well as psychosocial stressors including sexual trauma history and intimate partner violence. Many women Veterans of childbearing age experience poverty and homelessness, which are key social determinants of poor reproductive health outcomes. Read More

View Article

Download full-text PDF

Source
http://www.thieme-connect.de/DOI/DOI?10.1055/s-0039-1678753
Publisher Site
http://dx.doi.org/10.1055/s-0039-1678753DOI Listing
November 2018
1 Read

Indigenous Doulas: A literature review exploring their role and practice in western maternity care.

Midwifery 2019 Apr 16;75:52-58. Epub 2019 Apr 16.

Charles Darwin University, Australia.

Objective: The purpose of this article is to establish a body of literature exploring the emergent topic of Indigenous doulas, in relation to Indigenous communities in remote locations, where women are routinely evacuated and no longer supported to give birth. In doing so the article will synthesise and critique key concepts in the literature and identify gaps for prioritisation in future research.

Design: The methodology is influenced by Indigenous, decolonising and feminist theoretical standpoints. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S02666138193008
Publisher Site
http://dx.doi.org/10.1016/j.midw.2019.04.005DOI Listing
April 2019
2 Reads

Evaluation of Placental Perfusion Based on Intravoxel Incoherent Motion Diffusion Weighted Imaging (IVIM-DWI) and Its Predictive Value for Late-Onset Fetal Growth Restriction.

Geburtshilfe Frauenheilkd 2019 Apr 12;79(4):396-401. Epub 2018 Dec 12.

Department of Medical Image, Guangzhou Women and Children's Medical Center, Guangzhou, China.

The aim of this study was to investigate placental blood perfusion in middle and late pregnancy and explore its predictive value for fetal growth restriction (FGR). All pregnant women included in the study were examined using placental intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI). Three IVIM parameters (D, f, D*) were obtained for each pregnant woman and analyzed using Image J software. Read More

View Article

Download full-text PDF

Source
http://www.thieme-connect.de/DOI/DOI?10.1055/a-0717-5275
Publisher Site
http://dx.doi.org/10.1055/a-0717-5275DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461467PMC
April 2019
1 Read

Exploring the effect of implementation and context on a stepped-wedge randomised controlled trial of a vital sign triage device in routine maternity care in low-resource settings.

Implement Sci 2019 Apr 18;14(1):38. Epub 2019 Apr 18.

Department of Women and Children's Health, School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, London, SE1 7EH, UK.

Background: Interventions aimed at reducing maternal mortality are increasingly complex. Understanding how complex interventions are delivered, to whom, and how they work is key in ensuring their rapid scale-up. We delivered a vital signs triage intervention into routine maternity care in eight low- and middle-income countries with the aim of reducing a composite outcome of morbidity and mortality. Read More

View Article

Download full-text PDF

Source
https://implementationscience.biomedcentral.com/articles/10.
Publisher Site
http://dx.doi.org/10.1186/s13012-019-0885-3DOI Listing
April 2019
2 Reads

Reproductive outcomes following treatment for a gynecological cancer diagnosis: a systematic review.

J Cancer Surviv 2019 Apr 17;13(2):269-281. Epub 2019 Apr 17.

Kids Cancer Centre, Sydney Children's Hospital, Sydney, NSW, 2031, Australia.

Purpose: Fertility treatments are available for women diagnosed with a gynecological malignancy, which is important for women who desire a biological family subsequent to treatment. The objective of this study was to report reproductive outcomes following fertility-sparing treatment for a gynaecological cancer.

Methods: Electronic databases were searched to identify studies that reported on reproductive outcomes after treatment for a gynecological malignancy. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s11764-019-00749-x
Publisher Site
http://dx.doi.org/10.1007/s11764-019-00749-xDOI Listing
April 2019
2 Reads

Cardiovascular Disease: Lower Extremity Deep Venous Thrombosis.

FP Essent 2019 Apr;479:21-29

Womack Army Medical Center Department of the Army, WAMC Stop A 2817 Reilly Rd, Ft Bragg, NC 28310-7301.

Risk factors for deep venous thrombosis (DVT) include immobility, recent or current hospitalization, recent surgery, recent infection, and cancer. Patients with suspected venous thromboembolism should be evaluated with the Wells score or modified Wells score (which adds a previous DVT) to determine the likelihood of DVT. A low or moderate probability score and a normal D-dimer test result exclude DVT. Read More

View Article

Download full-text PDF

Source
April 2019
2 Reads

Diabetes in pregnancy in associations with perinatal and postneonatal mortality in First Nations and non-Indigenous populations in Quebec, Canada: population-based linked birth cohort study.

BMJ Open 2019 Apr 15;9(4):e025084. Epub 2019 Apr 15.

Obstetrics and Gynecology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, and Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada.

Objective: Both pregestational and gestational diabetes mellitus (PGDM, GDM) occur more frequently in First Nations (North American Indians) pregnant women than their non-Indigenous counterparts in Canada. We assessed whether the impacts of PGDM and GDM on perinatal and postneonatal mortality may differ in First Nations versus non-Indigenous populations.

Design: A population-based linked birth cohort study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjopen-2018-025084DOI Listing
April 2019
1 Read

Derivation and validation of a model predicting the likelihood of vaginal birth following labour induction.

BMC Pregnancy Childbirth 2019 Apr 16;19(1):130. Epub 2019 Apr 16.

Division of Maternal-Fetal Medicine, Department of Obstetrics & Gynaecology, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada.

Background: There is high-quality evidence supporting induction of labour (IOL) for a number of maternal and fetal indications. However, one fifth of inductions fail to result in vaginal births, requiring cesarean deliveries. This has negative clinical, emotional and resource implications. Read More

View Article

Download full-text PDF

Source
https://bmcpregnancychildbirth.biomedcentral.com/articles/10
Publisher Site
http://dx.doi.org/10.1186/s12884-019-2232-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469110PMC
April 2019
2 Reads

Screening hysteroscopy in subfertile women and women undergoing assisted reproduction.

Cochrane Database Syst Rev 2019 Apr 16;4:CD012856. Epub 2019 Apr 16.

Department of Reproductive Medicine, Christian Medical College, Ida Scudder Road, Vellore, Tamil Nadu, India, 632004.

Background: Screening hysteroscopy in infertile women with unexplained infertility, or prior to intrauterine insemination (IUI) or in vitro fertilisation (IVF) may reveal intrauterine pathology that may not be detected by routine transvaginal ultrasound. Hysteroscopy, whether purely diagnostic or operative may improve reproductive outcomes.

Objectives: To assess the effectiveness and safety of screening hysteroscopy in subfertile women undergoing evaluation for infertility, and subfertile women undergoing IUI or IVF. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/14651858.CD012856.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472583PMC
April 2019
2 Reads

Challenges associated with the development and transfer of assisted breeding technology in marsupials and monotremes: lessons from the koala, wombat and short-beaked echidna.

Authors:
Stephen Johnston

Reprod Fertil Dev 2019 Apr 17. Epub 2019 Apr 17.

This reflective review describes how a research model, which was originally established for the successful AI of the koala (Phascolarctos cinereus), is currently being developed and extended to the wombat (Lasiorhinus latifrons and Vombatus ursinus) and short-beaked echidna (Tachyglossus aculeatus). The research model centres around the establishment of an AI program and involves: (1) semen collection, evaluation and preservation, requiring an understanding of male reproductive physiology and gamete biology; (2) timing of insemination, based on a knowledge of oestrous cycle and gestation physiology and oestrous behaviour; and (3) the appropriate placement of semen, which relies on an accurate description of female reproductive anatomy. Published and unpublished studies of assisted breeding technology (ABT) development in all three species of Australian mammals reported in this review (koala, wombat and short-beaked echidna) clearly demonstrate the importance of recognising species-specific variation in reproductive biology. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1071/RD18113DOI Listing
April 2019
1 Read

Sex-specific regulation of stress-induced fetal glucocorticoid surge by the mouse placenta.

Am J Physiol Endocrinol Metab 2019 Apr 16. Epub 2019 Apr 16.

Department for Obstetrics and Fetal Medicine. University Medical Center Hamburg Eppendorf, Germany.

Antenatal stress increases the prevalence of diseases in later life, which shows a strong sex-specific effect. However, the underlying mechanisms remain unknown. Maternal glucocorticoids can be elevated by stress and are potential candidates to mediate the effects of stress on the offspring sex-specifically. Read More

View Article

Download full-text PDF

Source
https://www.physiology.org/doi/10.1152/ajpendo.00551.2018
Publisher Site
http://dx.doi.org/10.1152/ajpendo.00551.2018DOI Listing
April 2019
4 Reads

Common Breast Problems.

Am Fam Physician 2019 Apr;99(8):505-514

Thomas Jefferson University, Philadelphia, PA, USA.

Palpable breast masses, mastalgia, and nipple discharge are commonly encountered symptoms in outpatient practice, causing significant patient anxiety and precipitating medical consultation. The initial workup includes a detailed clinical history and physical examination. Women presenting with a breast mass will require imaging and further assessment to exclude cancer. Read More

View Article

Download full-text PDF

Source
April 2019
1 Read

Clinical utility of sperm DNA damage in male infertility.

Panminerva Med 2019 Jun;61(2):118-127

ANDROFERT Andrology and Human Reproduction Clinic, Referral Center for Male Reproduction, Campinas, Brazil.

Sperm DNA fragmentation (SDF) is an advanced test of sperm function that is utilized during male fertility evaluation. Recently, a guideline was published highlighting the detrimental impact of SDF on sperm function identifying practice-based clinical indications for SDF testing. This review illustrates the commonly utilized SDF measurement techniques and explores the current evidence behind their utility in clinical practice. Read More

View Article

Download full-text PDF

Source
https://www.minervamedica.it/index2.php?show=R41Y2019N02A011
Publisher Site
http://dx.doi.org/10.23736/S0031-0808.18.03530-9DOI Listing
June 2019
3 Reads
2.276 Impact Factor

Health-related quality of life during pregnancy: a repeated measures study of changes from the first trimester to birth.

Acta Obstet Gynecol Scand 2019 Apr 15. Epub 2019 Apr 15.

Department of Obstetrics and Gynecology, Paule de Viguier Hospital, CHU Toulouse, Toulouse, France.

Introduction: The objective was to evaluate the quality of life of pregnant women with a full-term birth from the first trimester to the 9th month using the EQ5D-3L questionnaire, comparing physiological, simple pathological or complex pathological pregnancies.

Material And Methods: A prospective cohort of 500 pregnant women over the age of 18 was monitored between 2015 and 2017 at the Toulouse University Hospital (France). The data were collected monthly with an online report. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/aogs.13624DOI Listing
April 2019
1 Read

Therapeutic Potential of Regulatory T Cells in Preeclampsia-Opportunities and Challenges.

Front Immunol 2019 21;10:478. Epub 2019 Mar 21.

Robinson Research Institute and Adelaide Medical School, University of Adelaide, Adelaide, SA, Australia.

Inflammation is a central feature and is implicated as a causal factor in preeclampsia and other hypertensive disorders of pregnancy. Inflammatory mediators and leukocytes, which are elevated in peripheral blood and gestational tissues, contribute to the uterine vascular anomalies and compromised placental function that characterize particularly the severe, early onset form of disease. Regulatory T (Treg) cells are central mediators of pregnancy tolerance and direct other immune cells to counteract inflammation and promote robust placentation. Read More

View Article

Download full-text PDF

Source
https://www.frontiersin.org/article/10.3389/fimmu.2019.00478
Publisher Site
http://dx.doi.org/10.3389/fimmu.2019.00478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448013PMC
March 2019
2 Reads

Antifertility effectiveness of a novel polymer matrix composite and its influence on the endometrium in rhesus macaques (Macaca mulatta).

Contraception 2019 Apr 10. Epub 2019 Apr 10.

Family Planning Research Institute, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, PR China; Reproductive Medicine Center, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, PR China. Electronic address:

Objective(s): To explored the antifertility effectiveness and influence on the endometrium of a micro-copper/low-density polyethylene/methyl vinyl silicone rubber (Cu/LDPE/MVQ) composite in rhesus macaques.

Study Design: Healthy reproductive aged female rhesus macaques underwent abdominal hysterotomy for surgical placement of either the experimental Cu/LDPE/MVQ composite (Cu/LDPE/MVQ, n=5), bare copper wire (Cu, n=5), or hysterotomy only sham-operation group [(SOI, n=4), (SOII, n=6)]. Females in the Cu/LPDE/MVQ, Cu, and SOI groups were housed with fertile males for approximately 3 menstrual cycles. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.contraception.2019.03.049DOI Listing
April 2019
1 Read

Potential clinical benefits and limitations of fetal virtopsy using high-field MRI at 7 Tesla versus stereomicroscopic autopsy to assess first trimester fetuses.

Prenat Diagn 2019 Apr 12. Epub 2019 Apr 12.

IMOGEN - Centre of Advanced Research Studies, Emergency County Hospital, Cluj-Napoca, Romania.

Objective: The aim of this study was to establish the diagnostic accuracy of high-field magnetic resonance imaging (MRI) at 7 Tesla (T) compared to that of stereomicroscopic autopsy for assessing first trimester fetuses.

Methods: Nine consecutive cases of first trimester fetuses resulting from spontaneous and therapeutic pregnancy termination were considered. The cases were divided into two groups according to gestational age: the Embryo Group with cases of 9-10 gestational weeks (GW) and the Fetus Group with cases of 13 GW. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/pd.5457DOI Listing
April 2019
1 Read

How Can Pelvic MRI with Diffusion-Weighted Imaging Help My Pregnant Patient?

Am J Perinatol 2019 Apr 12. Epub 2019 Apr 12.

Division of Abdominal Imaging, Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

The purpose of this review is to explain how diffusion-weighted imaging (DWI) is used during magnetic resonance imaging (MRI) exams in pregnant patients for specific maternal indications, including evaluation of acute pelvic pain, adnexal masses, cancer diagnosis and staging, and morbidly adherent placenta. While ultrasound is often the appropriate initial imaging for evaluating a pregnant patient, MRI can be helpful when a pelvic ultrasound is indeterminate. MRI has advantages in that it does not use ionizing radiation and has shown no known deleterious effects to the fetus. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/s-0039-1685492DOI Listing
April 2019
1 Read

Crash sign: a new first-trimester sonographic marker of spina bifida.

Ultrasound Obstet Gynecol 2019 Apr 11. Epub 2019 Apr 11.

Fetal Medicine Unit, Elizabeth Garrett Anderson Wing, University College London Hospital, 235 Euston Road, London, NW1 2BU.

Objectives: To describe a new first trimester sonographic sign associated with open fetal spina bifida ("crash sign") where there is posterior displacement and deformation of the mesencephalon against the occipital bone in the axial view, and to evaluate its clinical usefulness in the first trimester diagnosis of spina bifida.

Methods: This was a retrospective review of patients referred to three fetal medicine centres in the first trimester (11-13+6 weeks) with suspected spina bifida. Spina bifida was confirmed by direct visualisation of the spinal defect by two experts and, where possible, examined at fetal post-mortem. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1002/uog.20285
Publisher Site
http://dx.doi.org/10.1002/uog.20285DOI Listing
April 2019
7 Reads
3.853 Impact Factor

Heterotopic atypical trophoblasts mimicking ectopic choriocarcinoma coexistent with a viable intrauterine pregnancy: A diagnostic dilemma.

Gynecol Oncol Rep 2019 May 26;28:91-93. Epub 2019 Mar 26.

Department of Obstetrics and Gynecology, University of Washington, Seattle, WA, United States of America.

•Ectopic choriocarcinoma coexistent with viable IUP is rare but has been reported.•Atypical and proliferative trophoblasts are normal in an early conceptus.•Evaluation including MRI and CXR did not reveal metastatic choriocarcinoma. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.gore.2019.03.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441726PMC
May 2019
1 Read

Implementation of the Family Nurse Partnership programme in England: experiences of key health professionals explored through trial parallel process evaluation.

BMC Nurs 2019 2;18:13. Epub 2019 Apr 2.

2Centre for Trials Research, Cardiff University, Cardiff, CF14 4YS UK.

Background: The Family Nurse Partnership (FNP) programme was introduced to support young first-time mothers. A randomised trial found FNP added little short-term benefit compared to usual care. The study included a comprehensive parallel process evaluation, including focus groups, conducted to aid understanding of the introduction of the programme into a new service and social context. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12912-019-0338-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444391PMC
April 2019
1 Read

Incidence and features of thrombosis in children with inherited antithrombin deficiency.

Haematologica 2019 Apr 11. Epub 2019 Apr 11.

Hospital Universitario Morales Meseguer, Universidad de Murcia, Murcia, Spain;

Pediatric thromboembolism (≤18 years) is very rare (0.07-0.14/10,000/year) but may be more prevalent in children with severe thrombophilia (protein C, protein S or antithrombin deficiency). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3324/haematol.2018.210666DOI Listing
April 2019
1 Read

An evaluation of whether a gestational weight gain of 5 to 9 kg for obese women optimizes maternal and neonatal health risks.

BMC Pregnancy Childbirth 2019 Apr 11;19(1):126. Epub 2019 Apr 11.

College of Veterinary Medicine and Biomedical Science, Texas A&M University, College Station, TX, 77843-4475, USA.

Background: Maternal obesity has a wide range of health effects on both the pregnant woman and developing fetus. The clinical significance of these disorders, combined with a dramatically increasing prevalence of obesity among pregnant women has precipitated a major health crisis in the United States. The most commonly used recommendations for gestational weight gain were established by the Institute of Medicine (IOM) in 2009 and have become well known and often adopted. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12884-019-2273-zDOI Listing
April 2019
1 Read

The prevalence of histologic acute chorioamnionitis among HIV infected pregnant women in Uganda and its association with adverse birth outcomes.

PLoS One 2019 11;14(4):e0215058. Epub 2019 Apr 11.

Department of Anatomic Pathology, University of California San Francisco, San Francisco, California, United States of America.

Background: Preterm birth (PTB) is a leading cause of neonatal mortality and longer-term morbidity. Acute chorioamnionitis (ACA) is a common cause of PTB, however, there are limited data on the prevalence of ACA and its association with PTB in resource limited settings.

Methods: Data and samples came from a clinical trial evaluating novel strategies for the prevention of malaria in HIV infected pregnant women in Uganda. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215058PLOS
April 2019
1 Read

Development of an Anatomical Silicone Model for Simulation-based Medical Training of Obstetric Anal Sphincter Injury Repair in Bangladesh.

Cureus 2019 Jan 31;11(1):e3991. Epub 2019 Jan 31.

Emergency Medicine, Memorial University of Newfoundland, St. John's, CAN.

Advancing global healthcare in developing countries has traditionally been an area of interest for many North American medical organizations, as they strive to improve patient outcomes by helping to control disease and death-related illnesses. Women's healthcare in developing countries, in particular, presents a unique set of complexities, revealing high maternal mortality statistics surrounding pregnancy, labor, and childbirth, which is often tied to home births without medically trained attendants. In September 2018, Team Broken Earth, a Canadian-based outreach initiative, hosted a three-day women's healthcare course in Dhaka, Bangladesh, which included simulation-based training stations, for the purpose of advancing clinical skills and education in regards to local labor and delivery. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7759/cureus.3991DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443516PMC
January 2019
1 Read

Prenatal Diagnosis and Successful Palliation of Absent Aortic Valve with Hypoplastic Left Heart Syndrome: A Case Report and Review of Literature.

AJP Rep 2019 Apr 9;9(2):e121-e126. Epub 2019 Apr 9.

Division of Pediatric Cardiology, University of Texas Medical Branch, Galveston, Texas.

 Congenital absence of the aortic valve leaflets is a rare association with hypoplastic left heart syndrome (HLHS).  A 37-year-old pregnant woman was referred for fetal evaluation of possible HLHS at 22 weeks of gestation. The fetal echocardiogram (ECHO) was remarkable for a hypoplastic left atrium, nearly atretic mitral valve, small left ventricle, and a hypoplastic aortic valve with severe aortic insufficiency. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/s-0038-1677480DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456327PMC
April 2019
1 Read

Prognostic Laboratory Parameters in Placental Abruption: A Retrospective Case-Control Study.

J Clin Med 2019 04 9;8(4). Epub 2019 Apr 9.

Department of Obstetrics and Gynecology, Medical University of Vienna, Spitalgasse 23, 1090 Vienna, Austria.

To evaluate routine laboratory parameters in women with and without placental abruption (PA) and in controls, 417 women were included in this retrospective cohort study in a tertiary-care center. 118 women with PA (Group A: 54 without vaginal bleeding and Group B: 64 with bleeding), 130 women without either PA or vaginal bleeding throughout their pregnancy (Group C), 123 women with vaginal bleeding but without PA (Group D), and 46 healthy pregnant women who had undergone a control laboratory evaluation in the second/third trimester for history of previous cytomegalovirus (additional control group) were included. Hemoglobin, leukocytes, thrombocytes, C-reactive protein (CRP), and fibrinogen were obtained within 48 hours before C-section and/or at the time of bleeding onset. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/jcm8040482DOI Listing
April 2019
1 Read

Feasibility of Postmortem Imaging Assessment of Brain: Liver Volume Ratios with Pathological Validation.

Fetal Diagn Ther 2019 Apr 10:1-8. Epub 2019 Apr 10.

Department of Radiology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom.

Introduction: Organ volumes at postmortem magnetic resonance imaging (PMMR) should reflect autopsy organ weights, and thus brain:liver volume ratios on imaging could be a surrogate for weight volume ratios at autopsy to indicate fetal growth restriction (FGR). This study aims to determine whether imaging-based organ volume ratios can replace autopsy organ weight ratios. Materials and Meth ods: An unselected cohort of perinatal deaths underwent PMMR prior to autopsy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000497158DOI Listing
April 2019
2 Reads