2,373 results match your criteria Evaluation of Fetal Death


[Effect of induction on maternal and neonatal outcomes of vaginal birth after cesarean].

Zhonghua Yi Xue Za Zhi 2020 Jul;100(25):1979-1982

Department of Perinatal Medicine, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China.

To investigate the effect of induction on maternal and neonatal outcomes of vaginal birth after cesarean section (VBAC). Retrospective cohort study. A total of 452 pregnant women who underwent trail of labor after cesarean section (TOLAC) from January 2015 to March 2019 of Beijing Obstetrics and Gynecology Hospital, Capital Medical University were enrolled. Read More

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http://dx.doi.org/10.3760/cma.j.cn112137-20191213-02720DOI Listing

[Comparative evaluation of ultrasonic virtopsia and classical autopsy for antenatal fetal death].

Arkh Patol 2020 ;82(3):51-54

Forensic Medicine Bureau, St. Petersburg, Russia.

Aim Of Study: Comparison of the data obtained by ultrasound examination of a pregnant woman with antenatal death of the fetus and stillborn child, with the autopsy results.

Materials And Methods: The protocols of ultrasound examinations and the autopsy protocols of 126 fetuses that died antenatally were analyzed.

Results: In our study of 126 patients, 95 showed no structural changes either during ultrasound examination or during further pathomorphological examination. Read More

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http://dx.doi.org/10.17116/patol20208203151DOI Listing
January 2020

Stillbirth in women with diabetes: a retrospective analysis of fetal autopsy reports.

J Matern Fetal Neonatal Med 2020 Jun 21:1-8. Epub 2020 Jun 21.

Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, University of Rochester Medical Center, Rochester, NY, USA.

Diabetes in pregnancy is associated with an increased rate of stillbirth. There are a wide variety of factors that have been implicated including placental insufficiency, hypoxia, hyperinsulinemia and impaired cardiac function. Furthermore, there is evidence that diabetic pregnancies have an increased rate of fetal cardiomyopathy as compared to non-diabetic pregnancies. Read More

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http://dx.doi.org/10.1080/14767058.2020.1779213DOI Listing

Prenatal ultrasound and magnetic resonance evaluation and fetal outcome in high-risk fetal tumors: A retrospective single-center cohort study over 20 years.

Acta Obstet Gynecol Scand 2020 Jun 11. Epub 2020 Jun 11.

Division of Neuroradiology and Musculoskeletal Radiology, Department of Radiology, Medical University of Vienna, Vienna, Austria.

Introduction: Fetal tumors are rare and usually followed by poor outcome. We describe our single-center experience with fetal tumors evaluated by ultrasound and magnetic resonance imaging (MRI). Our aims were to evaluate mortality and morbidity including long-term outcome and to determine which ultrasound and MRI characteristics were helpful for pre- and perinatal management. Read More

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http://dx.doi.org/10.1111/aogs.13933DOI Listing

Aortic Isthmus Doppler Velocimetry in Fetuses with Intrauterine Growth Restriction: A Literature Review.

Rev Bras Ginecol Obstet 2020 May 29;42(5):289-296. Epub 2020 May 29.

Fetal Medecine Post Graduation, Universidade Estácio de Sá, Rio de Janeiro, RJ, Brazil.

Intrauterine growth restriction (IUGR) is associated with poor perinatal prognosis and a higher risk of stillbirth, neonatal death, and cerebral palsy. Its detection and the evaluation of its severity by new Doppler velocimetric parameters, such as aortic isthmus (AoI), are of great relevance for obstetrical practice. The AoI is a vascular segment that represents a point of communication between the right and left fetal circulations. Read More

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http://dx.doi.org/10.1055/s-0040-1710301DOI Listing

Mitochondrial energetics and contents evaluated by flow cytometry in human maternal and umbilical cord blood.

Scand J Clin Lab Invest 2020 May 29:1-9. Epub 2020 May 29.

Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark.

Mitochondrial dysfunction may relate to metabolic disorders. The relation between maternal and fetal mitochondrial function needs attention due to heritage. To evaluate the use of the staining methods TetraMethylRhodamine Methyl Ester (TMRM) and Mitotracker Green (MTG) for flow cytometric measurements of umbilical cord blood mitochondrial function. Read More

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http://dx.doi.org/10.1080/00365513.2020.1768584DOI Listing

Placental histopathology in sickle cell disease: A descriptive and hypothesis-generating study.

Placenta 2020 Jun 17;95:9-17. Epub 2020 Apr 17.

Mount Sinai Hospital, Department of Obstetrics and Gynaecology, Division of Maternal-Fetal Medicine, Toronto, Canada; University of Toronto, Department of Medicine, Toronto, Canada; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Canada.

Introduction: Abnormal placental development is a unifying factor amongst many adverse pregnancy outcomes (APOs) in Sickle Cell Disease (SCD). Our aim was to describe placental histopathologic findings in women with SCD and their relationship with APOs, and to explore the association between antenatal sonographic findings and placental pathology.

Methods: Retrospective single-centre case series of all pregnant women with SCD (January 2000-December 2017), pregnancy beyond 20 weeks' gestation, and available placenta histopathology. Read More

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http://dx.doi.org/10.1016/j.placenta.2020.04.003DOI Listing

Brasilian List of Avidable Causes of Death that can be avoided by National Health System interventions, and its applicability for analysis of perinatal deaths in municipalities in the states of Rio de Janeiro and São Paulo, Brazil, 2011.

Epidemiol Serv Saude 2020 15;29(2):e201942. Epub 2020 May 15.

Instituto de Saúde Coletiva, Universidade Federal Fluminense, Niterói, RJ, Brasil.

Objective to assess the applicability of the Brazilian List of Avoidable Causes of Death (BAL) to perinatal mortality in public maternity hospitals in the states of Rio de Janeiro (RJ) and São Paulo (SP) in 2011. Methods this was a descriptive case series study of perinatal deaths using primary data from the Mortality Information System; the BAL was applied, with adaptations (codes P20.9 and P70-74) and, in addition in Rio de Janeiro the Extended Wigglesworth (EW) Classification was also used. Read More

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http://dx.doi.org/10.5123/s1679-49742020000200019DOI Listing

A Proposed Plan for Prenatal Care to Minimize Risks of COVID-19 to Patients and Providers: Focus on Hypertensive Disorders of Pregnancy.

Am J Perinatol 2020 Jun 12;37(8):837-844. Epub 2020 May 12.

Department of Obstetrics, Gynecology, Reproductive Sciences, University of Texas-Houston, Houston, Texas.

Hypertensive disorders are the most common medical complications of pregnancy and a major cause of maternal and perinatal morbidity and death. The detection of elevated blood pressure during pregnancy is one of the cardinal aspects of optimal antenatal care. With the outbreak of novel coronavirus disease 2019 (COVID-19) and the risk for person-to-person spread of the virus, there is a desire to minimize unnecessary visits to health care facilities. Read More

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http://dx.doi.org/10.1055/s-0040-1710538DOI Listing

Model based estimation of QT intervals in non-invasive fetal ECG signals.

PLoS One 2020 11;15(5):e0232769. Epub 2020 May 11.

Healthcare Engineering Innovation Center (HEIC), Department of Biomedical Engineering, Khalifa University, Abu Dhabi, UAE.

The end timing of T waves in fetal electrocardiogram (fECG) is important for the evaluation of ST and QT intervals which are vital markers to assess cardiac repolarization patterns. Monitoring malignant fetal arrhythmias in utero is fundamental to care in congenital heart anomalies preventing perinatal death. Currently, reliable detection of end of T waves is possible only by using fetal scalp ECG (fsECG) and fetal magnetocardiography (fMCG). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0232769PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7213701PMC

Study of Lethal Congenital Malformations at a Tertiary-Care Referral Centre in North India.

Cureus 2020 Apr 1;12(4):e7502. Epub 2020 Apr 1.

Obstetrics and Gynaecology, Maulana Azad Medical College, New Delhi, IND.

Lethal congenital malformations (LCMs) are fatal birth defects that are an important cause of fetal/neonatal death. There is a lack of informative data about these malformations in India, a country that shares the maximum burden of neonatal mortality due to congenital birth defects. Therefore, we conducted a retrospective analysis to know the prevalence of LCMs in late pregnancy, to find out associated factor/variables and to evaluate fetal/neonatal outcome of such anomalies; at a tertiary-care referral centre in North India. Read More

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http://dx.doi.org/10.7759/cureus.7502DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7195199PMC

Rituximab, MS, and pregnancy.

Neurol Neuroimmunol Neuroinflamm 2020 Jul 1;7(4). Epub 2020 May 1.

From the Department of Research & Evaluation (J.B.S.), Kaiser Permanente Southern California; Department of Neurology (K.H.), St. Josef Hospital, Bochum, Germany; Department of Clinical Neuroscience (K.F., F.P.), Karolinska Institute; Center for Neurology (K.F.), Academic Specialist Center, Stockholm, Sweden; Department of Obstetrics & Gynecology - Maternal Fetal Medicine (D.J.L.), Stanford University School of Medicine, Stanford, CA; Department of Neurology (F.P.), Karolinska University Hospital, Stockholm, Sweden; and Department of Neurology (A.L.-G.), Los Angeles Medical Center, Southern California Permanente Medical Group, Los Angeles, CA.

Objective: To describe the safety and efficacy of rituximab (RTX) in MS and pregnancy, we conducted a retrospective cohort study of 74 pregnancies among 55 women treated with RTX for MS and their offspring.

Methods: We used prospectively collected information from the electronic health record at Kaiser Permanente Southern California between 2012 and 2019 of mother and baby to identify treatment history, pregnancy outcomes, and relapses.

Results: Last RTX exposure before conception occurred between 1. Read More

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http://dx.doi.org/10.1212/NXI.0000000000000734DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217660PMC

Mild Neonatal Acidemia is Associated with Neonatal Morbidity at Term.

Am J Perinatol 2020 Apr 22. Epub 2020 Apr 22.

Department of Women's Health, The University of Texas at Austin, Dell Medical School, Austin, Texas.

Objective:  The aim of this study is to determine the association between mild acidemia (umbilical artery [UA] pH: 7.11-7.19) and neonatal morbidity in neonates at term. Read More

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http://dx.doi.org/10.1055/s-0040-1708800DOI Listing

Looking back, moving forward: 50 years of South African Medical Research Council alcohol-related publications.

S Afr Med J 2019 Dec 5;109(11b):30-35. Epub 2019 Dec 5.

Alcohol, Tobacco and Other Drug Research Unit, South African Medical Research Council, Cape Town, South Africa; Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University and Tygerberg Hospital, South Africa.

Background: Alcohol is one of the highest risk factors for death and disability in South Africa (SA). Objective. To explore the trajectory of empirical research on alcohol in SA between 1969 and 2019, with an emphasis on South African Medical Research Council (SAMRC) authored publications. Read More

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http://dx.doi.org/10.7196/SAMJ.2019.v109i11b.14277DOI Listing
December 2019

Prenatal stress enhances NNK-induced lung tumors in A/J mice.

Carcinogenesis 2020 Apr 6. Epub 2020 Apr 6.

Sidney Kimmel Cancer Center. Department of Oncology, The Johns Hopkins University, School of Medicine, Baltimore, Maryland, USA.

Children born to women who experience stress during pregnancy have an increased risk of cancer in later life, but no previous animal studies have tested such a link. We questioned whether prenatal stress in A/J mice affected the development of lung tumors after postnatal response to tobacco specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Timed-bred A/J mice were randomly assigned on gestation day 12. Read More

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http://dx.doi.org/10.1093/carcin/bgaa033DOI Listing

Evaluation of mode of birth in pregnant women with heart disease.

Eur J Obstet Gynecol Reprod Biol 2020 May 6;248:150-155. Epub 2020 Mar 6.

Department of Obstetrics, Leiden University Medical Centre, the Netherlands.

Objective: Maternal heart disease (HD) complicates 1-4 % of pregnancies and is associated with adverse maternal and fetal outcomes. Although vaginal birth is generally recommended in the guidelines, cesarean section (CS) rates in women with HD are often high. Aim of the present study was to evaluate mode of birth and pregnancy outcomes in women with HD in a tertiary care hospital in the Netherlands. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2020.03.013DOI Listing

Multidisciplinary study of sudden unexpected infant death in Liguria (Italy): an nine-year report.

Minerva Pediatr 2020 Apr 2. Epub 2020 Apr 2.

Department of Pediatric Emergency - Sudden Infant Death Syndrome Liguria Centre, Istituto Giannina Gaslini, Genoa, Italy.

We conducted a retrospective analysis of cases of SUID referred to the SIDS-ALTE Center of the Liguria Region (Italy) from 2010 to 2018. In all cases, the death scene was inspected and a multidisciplinary post-mortem evaluation was conducted. Our aim was to analyze the epidemiological data and etiological distribution. Read More

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http://dx.doi.org/10.23736/S0026-4946.20.05599-1DOI Listing

Neonatal Organ and Tissue Donation for Research: Options Following Death by Natural Causes.

Cell Tissue Bank 2020 Jun 13;21(2):289-302. Epub 2020 Mar 13.

Department of Neonatology, Cleveland Clinic Foundation, Cleveland, OH, USA.

The donation of organs and tissues from neonates (birth to 28 days) for transplantation has been a relatively infrequent occurrence. Less common has been the use of neonatal organs and tissues for research. Specific ethical and legal questions beg for rational and transparent guidelines with which to evaluate referrals of potential donors. Read More

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http://dx.doi.org/10.1007/s10561-020-09822-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223177PMC

The importance of depression during pregnancy.

JBRA Assist Reprod 2020 Mar 11. Epub 2020 Mar 11.

Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran.

Objective: Today, the high prevalence of depression is one of the major health problems of pregnant women. This study aimed to assess the relationship between antenatal depression, pregnancy and neonatal outcomes.

Methods: This cohort study involved 394 pregnant women referred to the prenatal care clinic at the Al- Zahra Hospital, affiliated to Guilan University of Medical Sciences, Iran. Read More

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http://dx.doi.org/10.5935/1518-0557.20200010DOI Listing

Neonatal Intensive Care Unit-Level Patent Ductus Arteriosus Treatment Rates and Outcomes in Infants Born Extremely Preterm.

J Pediatr 2020 May 4;220:34-39.e5. Epub 2020 Mar 4.

Department of Pediatrics, Mount Sinai Hospital, Toronto, Ontario, Canada; Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada; Maternal-infant Care Research Centre, Department of Pediatrics, Mount Sinai Hospital, Toronto, Ontario, Canada; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada. Electronic address:

Objectives: To assess associations between neonatal intensive care unit (NICU)-level patent ductus arteriosus (PDA) treatment rates (pharmacologic or surgical) and neonatal outcomes.

Study Design: This cohort study included infants born at 24-28 weeks of gestation and birth weight <1500 g in 2007-2015 in NICUs caring for ≥100 eligible infants in 6 countries. The ratio of observed/expected (O/E) PDA treatment rates was derived for each NICU by estimating the expected rate using a logistic regression model adjusted for potential confounders and network. Read More

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http://dx.doi.org/10.1016/j.jpeds.2020.01.069DOI Listing
May 2020
3.790 Impact Factor

Pregnancy in Thalassemia and Sickle Cell Disease: The Experience of an Italian Thalassemia Center.

Front Mol Biosci 2020 14;7:16. Epub 2020 Feb 14.

Department of Chemistry, Sapienza University of Rome, Rome, Italy.

The life expectancy of thalassemia patients has increased significantly in recent years being the most "elderly" patients approaching or are over 50 years old. Consequently, patients' perspectives have changed, leading them to longer-term planning with a consequent increase in their reproductive potential and desire to have children. Crucial points in the management of pregnancy in thalassemia are the iron chelation therapy before and during pregnancy, the antithrombotic prophylaxis, the management of transfusion therapy according to the modified transfusion requirement, a cardiologic monitoring for hemodynamic changes that expose an increased risk of heart failure. Read More

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http://dx.doi.org/10.3389/fmolb.2020.00016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7033579PMC
February 2020

Management of Stillbirth: Obstetric Care Consensus No, 10.

Authors:

Obstet Gynecol 2020 03;135(3):e110-e132

Stillbirth is one of the most common adverse pregnancy outcomes, occurring in 1 in 160 deliveries in the United States. In developed countries, the most prevalent risk factors associated with stillbirth are non-Hispanic black race, nulliparity, advanced maternal age, obesity, preexisting diabetes, chronic hypertension, smoking, alcohol use, having a pregnancy using assisted reproductive technology, multiple gestation, male fetal sex, unmarried status, and past obstetric history. Although some of these factors may be modifiable (such as smoking), many are not. Read More

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http://dx.doi.org/10.1097/AOG.0000000000003719DOI Listing

Management of Stillbirth: Obstetric Care Consensus No, 10 Summary.

Authors:

Obstet Gynecol 2020 Mar;135(3):747-751

Stillbirth is one of the most common adverse pregnancy outcomes, occurring in 1 in 160 deliveries in the United States. In developed countries, the most prevalent risk factors associated with stillbirth are non-Hispanic black race, nulliparity, advanced maternal age, obesity, preexisting diabetes, chronic hypertension, smoking, alcohol use, having a pregnancy using assisted reproductive technology, multiple gestation, male fetal sex, unmarried status, and past obstetric history. Although some of these factors may be modifiable (such as smoking), many are not. Read More

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http://dx.doi.org/10.1097/AOG.0000000000003720DOI Listing

Implementation of a multidisciplinary perinatal emergency response team improves time to definitive obstetrical evaluation and fetal assessment.

J Trauma Acute Care Surg 2020 May;88(5):615-618

From the Division of Trauma (J.A.S., A.S., N.P., B.P., D.Y.K.), Harbor-UCLA Medical Center; Los Angeles BioMedical Research Institute (J.A.S., R.E., A.M., B.P., D.Y.K.); Division of Obstetrics and Gynecology (R.E.), and Division of General Surgery (A.M.), Harbor-UCLA Medical Center, Torrance, California.

Background: Trauma is the leading cause of nonobstetric death during pregnancy and is associated with an increased risk of maternal and fetal mortality. In an effort to improve the delivery of care to pregnant trauma patients, we developed an institutional multidisciplinary quality initiative designed to improve response times of nontrauma specialists and ensure immediate availability of resources. We hypothesized that implementation of a perinatal emergency response team (PERT) would improve time to patient and fetal evaluation and monitoring by the obstetrics (OB) team and improve both maternal and fetal outcomes. Read More

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http://dx.doi.org/10.1097/TA.0000000000002615DOI Listing
May 2020
1.970 Impact Factor

Obstetric Care Consensus #10: Management of Stillbirth: (Replaces Practice Bulletin Number 102, March 2009).

Am J Obstet Gynecol 2020 Mar 29;222(3):B2-B20. Epub 2020 Jan 29.

Society for Maternal-Fetal Medicine, 409 12 St. SW, Washington, DC 20024, USA.

Stillbirth is one of the most common adverse pregnancy outcomes, occurring in 1 in 160 deliveries in the United States. In developed countries, the most prevalent risk factors associated with stillbirth are non-Hispanic black race, nulliparity, advanced maternal age, obesity, preexisting diabetes, chronic hypertension, smoking, alcohol use, having a pregnancy using assisted reproductive technology, multiple gestation, male fetal sex, unmarried status, and past obstetric history. Although some of these factors may be modifiable (such as smoking), many are not. Read More

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http://dx.doi.org/10.1016/j.ajog.2020.01.017DOI Listing

Postmortem examination protocol and systematic re-evaluation reduce the proportion of unexplained stillbirths.

J Perinat Med 2020 Jan 28. Epub 2020 Jan 28.

Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Background Stillbirth often remains unexplained, mostly due to a lack of any postmortem examination or one that is incomplete and misinterpreted. Materials and methods This retrospective cohort study was conducted at the Department of Obstetrics and Gynecology, Helsinki University Hospital, Finland, and comprised 214 antepartum singleton stillbirths from 2003 to 2015. Maternal and fetal characteristics and the results of the systematic postmortem examination protocol were collected from medical records. Read More

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http://dx.doi.org/10.1515/jpm-2019-0426DOI Listing
January 2020

The invisible burden of malaria-attributable stillbirths - Authors' reply.

Lancet 2020 01;395(10220):268-269

Oxford Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1016/S0140-6736(19)32968-XDOI Listing
January 2020

Murine models for studying treatment, prevention and pathogenesis of FNAIT.

Transfus Apher Sci 2020 Feb 31;59(1):102706. Epub 2019 Dec 31.

Department of Laboratory Medicine, University Hospital of North Norway, Tromsø, Norway. Electronic address:

Maternal alloimmunization to paternally inherited antigens on fetal/neonatal platelets can cause fetal/neonatal alloimmune thrombocytopenia (FNAIT) after antibody-mediated removal of platelets from the fetal circulation. The complications vary from mild bleeding symptoms to severe intracranial hemorrhage and subsequent neurological impairment or death. Studies on in vivo mechanisms are challenging to measure directly in pregnant women, rendering murine models as valuable and attractive alternatives, despite some critical differences between mice and men affecting the translational value. Read More

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http://dx.doi.org/10.1016/j.transci.2019.102706DOI Listing
February 2020

Use of triptans during pregnancy? With caution!

Therapie 2019 Dec 20. Epub 2019 Dec 20.

Service de pharmacologie médicale et clinique, centre régional de pharmacovigilance, faculté de médecine, Inserm 1027, 31000 Toulouse, France.

We report cases, registered in the French national pharmacovigilance database, of fetal death and intrauterine growth retardation in women exposed to triptans during pregnancy. Triptans have vasoconstrictive properties and we wonder about their responsibility for these side effects. The use of triptans and other drugs exhibiting vasoconstrictive properties in pregnant women requires a careful benefits/risks evaluation. Read More

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http://dx.doi.org/10.1016/j.therap.2019.12.007DOI Listing
December 2019

Skeletal and Cardiac Rhabdomyolysis in a Live-Stranded Neonatal Bryde's Whale With Fetal Distress.

Front Vet Sci 2019 20;6:476. Epub 2019 Dec 20.

Department of Veterinary Histology and Pathology, Veterinary School, Institute of Animal Health and Food Safety, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain.

The main objective of wildlife forensic investigation is to recognize pathologic changes and cause of death. Even though it may not always be possible to determine the specific illness and/or etiology, the description and subsequent interpretation of the injuries provide an invaluable understanding of pathology in cetacean post-mortem investigations. Although pathological studies have been previously reported in various cetacean species, such descriptions of the infraorder remain rare. Read More

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http://dx.doi.org/10.3389/fvets.2019.00476DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6933440PMC
December 2019

Hydrogen Sulfide Attenuates the Neurotoxicity in the Animal Model of Fetal Alcohol Spectrum Disorders.

Neurotox Res 2020 Apr 4;37(4):977-986. Epub 2020 Jan 4.

Addiction Research Center, Shahroud University of Medical Sciences, Shahroud, Iran.

Fetal alcohol spectrum disorder (FASD), which is caused by prenatal alcohol exposure, can result in cell death in specific brain regions. Alcohol-induced neurocognitive defects offspring's are included with activation of oxidative-inflammatory cascade followed with wide apoptotic neurodegeneration in many brain's regions such as hippocampus. According to the latest studies, HS (hydrogen sulfide) can protect neuronal cells via antioxidant, anti-inflammatory, and anti-apoptotic mechanisms in different animal models. Read More

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http://dx.doi.org/10.1007/s12640-019-00152-5DOI Listing

Sudden intrauterine unexplained death: time to adopt uniform postmortem investigative guidelines?

BMC Pregnancy Childbirth 2019 Dec 30;19(1):526. Epub 2019 Dec 30.

"Lino Rossi" Research Center for the study and prevention of unexpected perinatal death and SIDS, Department of Biomedical, Surgical and Dental Sciences, University of Milan, Via della Commenda 19, 20122, Milan, Italy.

Background: Worldwide approximately 2.6 million are stillborn, mostly occurring in developing countries. In the great part these deaths are inexplicable. Read More

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http://dx.doi.org/10.1186/s12884-019-2603-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6936151PMC
December 2019

No. 394-Stillbirth Investigation.

Authors:
Line Leduc

J Obstet Gynaecol Can 2020 Jan;42(1):92-99

Montréal, QC. Electronic address:

Objectives: To provide an investigation protocol to help health care providers determine the cause of a fetal death.

Options: Consideration has been given to protocols for the investigation of fetal death that are currently available in Canada and in other countries.

Outcomes: Identification of possible causes of stillbirth and their relationship to future pregnancies. Read More

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http://dx.doi.org/10.1016/j.jogc.2019.04.001DOI Listing
January 2020

Malaria in Pregnancy: What the Obstetric Provider in Nonendemic Areas Needs to Know.

Obstet Gynecol Surv 2019 Sep;74(9):546-556

Assistant Professor, Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, San Francisco, CA.

Importance: Globally, more than 125 million women each year are at risk of malaria during pregnancy. Endemic regions carry the greatest burden; however, with globalization, providers in nonendemic regions are encountering increasing numbers of women exposed to or infected with malaria.

Objectives: The aim of this article is to provide obstetric providers in nonendemic areas with updated information on malaria infection in pregnancy focusing on pregnancy management and malaria prevention and treatment. Read More

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http://dx.doi.org/10.1097/OGX.0000000000000704DOI Listing
September 2019

Uterine rupture during pregnancy.

Ceska Gynekol 2019 ;84(5):345-350

Objective: A review of contemporary knowledge about uterine rupture during pregnancy, followed by a case-report of a patient with uterine rupture during pregnancy without an uterine scar.

Design: Review and case report.

Setting: Clinic of Obstetrics and Gynecology, University Hospital, Hradec Králové; Department of Gynecology and Obstetrics, Hospital Náchod. Read More

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December 2019

Co-existence of well-differentiated fetal adenocarcinoma of the lung with tuberculosis in a young female: A rare case report.

Medicine (Baltimore) 2019 Dec;98(49):e18282

Lung Cancer Center, Cancer Center, State Key Laboratory of Biotherapy, West China Hospital of Sichuan University.

Rationale: Fetal adenocarcinoma of the lung (FLAC) with fetal lung-like morphology is a rare entity of pulmonary adenocarcinoma. Well-differentiated fetal adenocarcinoma (WDFA) belongs to its the low-grade form, which possesses a relatively favorable prognosis. Tuberculosis (TB) is an aggressive infectious disease that has been ranked as one of the top 10 causes of death worldwide. Read More

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http://dx.doi.org/10.1097/MD.0000000000018282DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6919474PMC
December 2019

Immunomodulatory effects of interferon-γ on human fetal cardiac mesenchymal stromal cells.

Stem Cell Res Ther 2019 12 4;10(1):371. Epub 2019 Dec 4.

Department of Molecular Medicine and Surgery, Karolinska Institutet, BioClinicum J10:20, SE-171 64, Solna, Sweden.

Background: Mesenchymal stromal cells (MSCs), due to their regenerative and immunomodulatory properties, are therapeutically used for diseases, including heart failure. As early gestational-phase embryonic tissues exhibit extraordinary regenerative potential, fetal MSCs exposed to inflammation offer a unique opportunity to evaluate molecular mechanisms underlying preferential healing, and investigate their inherent abilities to communicate with the immune system during development. The principal aim of this study was to evaluate the effects of interferon-γ (IFNγ) on the immunomodulatory effects of first-trimester human fetal cardiac (hfc)-MSCs. Read More

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http://dx.doi.org/10.1186/s13287-019-1489-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6894330PMC
December 2019

Variability in intensive care unit admission among pregnant and postpartum women in Canada: a nationwide population-based observational study.

Crit Care 2019 11 27;23(1):381. Epub 2019 Nov 27.

Institute of Health Policy, Management and Evaluation, University of Toronto, 4th Floor, 155 College St., Toronto, ON, M5T 3M6, Canada.

Background: Pregnancy-related critical illness results in approximately 300,000 deaths globally each year. The objective was to describe the variation in ICU admission and the contribution of patient- and hospital-based factors in ICU admission among acute care hospitals for pregnant and postpartum women in Canada.

Methods: A nationwide cohort study between 2004 and 2015, comprising all pregnant or postpartum women admitted to Canadian hospitals. Read More

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http://dx.doi.org/10.1186/s13054-019-2660-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6881971PMC
November 2019

Prognostic value of diffusion-weighted magnetic resonance imaging of the fetal brain in fetal growth restriction: results of a prospective multicenter study.

Ultrasound Obstet Gynecol 2019 Nov 25. Epub 2019 Nov 25.

Obstetrical, Perinatal, and Pediatric Epidemiology Team and Biostatistics Sorbonne Paris Cité Research Center (U1153), INSERM and Université Paris Descartes, Paris, France.

Objective: To prospectively measure the apparent diffusion coefficient (ADC) values between 28 and 32 weeks of gestation in different cerebral territories of fetuses with estimated fetal weight (EFW) ≤ 5 centile to analyse their association with an adverse perinatal outcome.

Methods: A prospective multi-center study involving 6 tertiary perinatal centres was conducted. Inclusion criteria were: (i) singleton small-for-gestational-age (SGA) fetuses with EFW ≤ 5 percentile between 28 and 32 weeks of gestation whatever the results of the umbilical Doppler and maternal uterine Doppler examinations. Read More

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http://dx.doi.org/10.1002/uog.21926DOI Listing
November 2019

Stillbirth Associated With Infection in a Diverse U.S. Cohort.

Obstet Gynecol 2019 12;134(6):1187-1196

University of Utah Health Sciences, Salt Lake City, and Intermountain Health Care, Murray, Utah; RTI International, Research Triangle Park, North Carolina; the University of Virginia Healthcare, Charlottesville, Virginia; the University of Texas Medical Branch at Galveston, Galveston, Texas; Columbia University, New York, New York; the University of Texas Health Science Center at Houston, Houston, Texas; Rollins School of Public Health, Emory University, Atlanta, Georgia; the University of Texas at Austin, Austin, and the University of Texas Health Science Center at San Antonio, San Antonio, Texas; and Yale School of Medicine, New Haven, Connecticut.

Objective: To better characterize infection-related stillbirth in terms of pathogenesis and microbiology.

Methods: We conducted a secondary analysis of 512 stillbirths in a prospective, multisite, geographically, racially and ethnically diverse, population-based study of stillbirth in the United States. Cases underwent evaluation that included maternal interview, chart abstraction, biospecimen collection, fetal autopsy, and placental pathology. Read More

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http://dx.doi.org/10.1097/AOG.0000000000003515DOI Listing
December 2019

A randomized controlled trial comparing isosorbide dinitrate-oxytocin versus misoprostol-oxytocin at management of foetal intrauterine death.

PLoS One 2019 21;14(11):e0215718. Epub 2019 Nov 21.

Department of Infectology and Immunology, National Institute of Perinatology, Mexico City, Mexico.

Background: The metabolic activity of endogenous nitric oxide (NO) and the medical use of nitrovasodilatory drugs like isosorbide dinitrate have been shown to be potential inducers inducers of cervical ripening prior to surgical evacuation of the uterus.

Objective: To assess the therapeutic efficacy and safety of combined isosorbide dinitrate-oxytocin in the management of intrauterine foetal death (IUFD).

Methods: Sixty women with IUFD after 20 weeks of gestation requesting uterine evacuation were randomly selected to receive isosorbide dinitrate gel solution (80 mg/1. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215718PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6872136PMC

Glycogen Storage Disease Type IV Diagnosed at Fetal Autopsy.

Pediatr Dev Pathol 2019 Nov 20:1093526619890224. Epub 2019 Nov 20.

Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina.

Glycogen storage disease type IV (GSD IV; Andersen's disease) is a rare autosomal recessive disorder that results from defects in the gene (3p12.2) and subsequent deficiencies of glycogen branching. We report a case of GSD IV diagnosed at autopsy in a 35 4/7 weeks gestational age female neonate that died shortly after birth. Read More

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http://dx.doi.org/10.1177/1093526619890224DOI Listing
November 2019

Evaluation of umbilical cord entanglement as a predictive factor of adverse pregnancy outcomes: A meta-analysis.

Eur J Obstet Gynecol Reprod Biol 2019 Dec 1;243:150-157. Epub 2019 Nov 1.

First Department of Obstetrics and Gynecology, Alexandra Hospital, National and Kapodistrian University of Athens, Greece.

The purpose of the present systematic review is to summarize current data concerning the impact of umbilical cord entanglement on adverse pregnancy outcomes. We used the Medline, Scopus, EMBASE, Cochrane Central Register of Controlled Trials CENTRAL and Google Scholar databases. We selected all observational (both prospective and retrospective) studies for inclusion. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2019.10.038DOI Listing
December 2019

Optimization of nanoemulsion containing gemcitabine and evaluation of its cytotoxicity towards human fetal lung fibroblast (MRC5) and human lung carcinoma (A549) cells.

Int J Nanomedicine 2019 9;14:7323-7338. Epub 2019 Sep 9.

Integrated Chemical BioPhysics Research, Faculty of Science, University Putra Malaysia (UPM), Serdang, Selangor 43400, Malaysia.

Background: Gemcitabine (GEM) is a chemotherapeutic agent, which is known to battle cancer but challenging due to its hydrophilic nature. Nanoemulsion is water-in-oil (W/O) nanoemulsion shows potential as a carrier system in delivering gemcitabine to the cancer cell.

Methods: The behaviour of GEM in MCT/surfactants/NaCl systems was studied in the ternary system at different ratios of Tween 80 and Span 80. Read More

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http://dx.doi.org/10.2147/IJN.S212635DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6751780PMC
January 2020

Fetal Death Associated With Premature Mammary Gland Development and Lactation in a Mare Treated With Weekly Injections of Long-Acting Progesterone.

J Equine Vet Sci 2019 10 18;81:102783. Epub 2019 Jul 18.

Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois Urbana-Champaign, Urbana, IL. Electronic address:

A 14-year-old, 530-kg, multiparous, pregnant Quarter Horse mare was referred for evaluation of premature mammary gland development and lactation. The mare was in the seventh month of gestation. The mare had a history of subfertility and was receiving weekly injections of long-acting progesterone, prescribed by the referring veterinarian. Read More

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http://dx.doi.org/10.1016/j.jevs.2019.07.004DOI Listing
October 2019

Potentialities of Postmortem Magnetic Resonance Imaging for Identification of Live Birth and Stillbirth.

Bull Exp Biol Med 2019 Oct 26;167(6):823-826. Epub 2019 Oct 26.

V. I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia.

The potentialities of postmortem MRI for differential diagnosis of stillbirth and death of a live newborn are studied. The results of MRI and pathomorphological studies of autopsy material from 20 stillborns dead at weeks 22-40 of gestation (group 1) and 19 newborns dead at the age of 2 h to 36 days (group 2) are analyzed. Control group has been formed from 7 live newborns aged 1-7 days. Read More

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http://dx.doi.org/10.1007/s10517-019-04631-9DOI Listing
October 2019

Congenital Nephrotic Syndrome in India in the Current Era: A Multicenter Case Series.

Nephron 2020 25;144(1):21-29. Epub 2019 Oct 25.

Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India.

Background: There is a paucity of information on epidemiology, diagnosis, and treatment outcomes of congenital nephrotic syndrome (CNS) in developing countries.

Methods: Retrospective (2012-2017) review of case records undertaken across 12 Indian pediatric nephrology centers.

Results: Sixty-five children (58% male, median birth weight 2. Read More

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http://dx.doi.org/10.1159/000503303DOI Listing
October 2019
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Hypertensive disorders in pregnancy: 2019 National guideline.

S Afr Med J 2019 09 13;109(9):12723. Epub 2019 Sep 13.

Emeritus Professor: Department of Obstetrics and Gynaecology, University of KwaZulu-Natal, Durban, South Africa.

Background: Hypertensive disorders of pregnancy (HDP), including pre-eclampsia/eclampsia, account for significant maternal and fetal mortality globally and especially in South Africa. Objective. To formulate clinical guidelines for the management of HDP in order to substantially reduce the number of maternal deaths from HDP. Read More

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September 2019
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Pregnancy After Liver Transplant: Neonatal Outcomes and Long-Term Maternal Follow-up.

Transplant Proc 2019 Nov 15;51(9):2948-2951. Epub 2019 Oct 15.

Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Università Cattolica del Sacro Cuore, Department of General Surgery, General Surgery and Liver Transplant Unit, Rome, Italy.

Background: Today, women who have undergone liver transplantation enjoy better health, so they encounter more frequently the possibility of living pregnancy. Many questions about the safety of pregnancy are pending. This study analyzes pregnancy outcomes in women with a liver transplant managed at Policlinico Universitario "A. Read More

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http://dx.doi.org/10.1016/j.transproceed.2019.02.071DOI Listing
November 2019
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The Contribution of an Infectious Workup in Understanding Stillbirth.

Am J Perinatol 2019 Oct 10. Epub 2019 Oct 10.

Department of Obstetrics and Gynecology, Maternal Fetal Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada.

Objective:  This study was aimed to assess the utility of diagnostic tests of maternal and fetal infection in the evaluation of stillbirth.

Study Design:  A single-center retrospective study from January 2011 to December 2016 of all women presenting to the hospital with intrauterine fetal death at or after 20 weeks of gestation. Standard evaluation included review of medical records, clinical and laboratory inflammatory workup, maternal serologies, fetal autopsy, placental pathology, and fetal and placental cultures. Read More

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http://dx.doi.org/10.1055/s-0039-1697668DOI Listing
October 2019
1 Read