2,239 results match your criteria Evaluation of Fetal Death


Using fetal scalp stimulation with Doppler ultrasonography to enhance intermittent auscultation in low-resource settings: a diagnostic trial from Tanzania.

BMC Pregnancy Childbirth 2019 Feb 13;19(1):71. Epub 2019 Feb 13.

Hubert-Yeargan Center for Global Health, Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC, USA.

Background: Hypoxia during labor contributes to 2.2 million intrapartum and early neonatal deaths each year. An additional 0. Read More

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http://dx.doi.org/10.1186/s12884-019-2212-zDOI Listing
February 2019

Deferred and referred deliveries contribute to stillbirths in the Indian state of Bihar: results from a population-based survey of all births.

BMC Med 2019 Feb 7;17(1):28. Epub 2019 Feb 7.

Public Health Foundation of India, Sector 44, Institutional Area, Gurugram, National Capital Region, India.

Background: The India Newborn Action Plan (INAP) aims for < 10 stillbirths per 1000 births by 2030. A population-based understanding of risk factors for stillbirths compared with live births that could assist with reduction of stillbirths is not readily available for the Indian population.

Methods: Detailed interviews were conducted in a representative sample of all births between January and December 2016 from 182,486 households (96. Read More

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http://dx.doi.org/10.1186/s12916-019-1265-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366028PMC
February 2019
1 Read

Association of Prenatal Ultrasonographic Findings With Adverse Neonatal Outcomes Among Pregnant Women With Zika Virus Infection in Brazil.

JAMA Netw Open 2018 Dec 7;1(8):e186529. Epub 2018 Dec 7.

Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco.

Importance: Congenital Zika virus infection causes a spectrum of adverse birth outcomes, including severe birth defects of the central nervous system. The association of prenatal ultrasonographic findings with adverse neonatal outcomes, beyond structural anomalies such as microcephaly, has not been described to date.

Objective: To determine whether prenatal ultrasonographic examination results are associated with abnormal neonatal outcomes in Zika virus-affected pregnancies. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2018.6529DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324324PMC
December 2018
2 Reads

Parameters for estimating the time of death at perinatal autopsy of stillborn fetuses: a systematic review.

Int J Legal Med 2019 Mar 8;133(2):483-489. Epub 2019 Jan 8.

Pathology Unit, Department of Public Health, School of Medicine, University of Naples Federico II, Naples, Italy.

Background: Stillbirth is defined by the WHO as birth of a fetus with no vital signs, at or over 28 weeks of pregnancy age. The estimation of time of death in stillbirth appears crucial in forensic pathology. However, there are no validated methods for this purpose. Read More

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http://dx.doi.org/10.1007/s00414-019-01999-1DOI Listing
March 2019
1 Read
2.714 Impact Factor

Care prior to and during subsequent pregnancies following stillbirth for improving outcomes.

Cochrane Database Syst Rev 2018 12 17;12:CD012203. Epub 2018 Dec 17.

NHMRC Centre of Research Excellence in Stillbirth, Mater Research Institute - The University of Queensland (MRI-UQ), Level 3 Aubigny Place, Mater Health Services, Brisbane, Queensland, Australia, 4101.

Background: Stillbirth affects at least 2.6 million families worldwide every year and has enduring consequences for parents and health services. Parents entering a subsequent pregnancy following stillbirth face a risk of stillbirth recurrence, alongside increased risks of other adverse pregnancy outcomes and psychosocial challenges. Read More

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http://dx.doi.org/10.1002/14651858.CD012203.pub2DOI Listing
December 2018
3 Reads

Intrauterine fetal MR versus postmortem MR imaging after therapeutic termination of pregnancy: evaluation of the concordance in the detection of brain abnormalities at early gestational stage.

Eur Radiol 2018 Dec 12. Epub 2018 Dec 12.

Pediatric Radiology and Neuroradiology Department, Children's Hospital V. Buzzi - ASST Fatebenefratelli-Sacco, Via Castelvetro 32, 20154, Milan, Italy.

Background And Purpose: Fetal postmortem MR Imaging (pmMRI) has been recently used as an adjuvant tool to conventional brain autopsy after termination of pregnancy (TOP). Our purpose was to compare the diagnostic performance of intrauterine MRI (iuMRI) and pmMRI in the detection of brain anomalies in fetuses at early gestational age (GA).

Material And Methods: We retrospectively collected 53 fetuses who had undergone iuMRI and pmMRI for suspected brain anomalies. Read More

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http://dx.doi.org/10.1007/s00330-018-5878-0DOI Listing
December 2018

Cost-effectiveness of continuity of midwifery care for women with complex pregnancy: a structured review of the literature.

Health Econ Rev 2018 Dec 5;8(1):32. Epub 2018 Dec 5.

Menzies Health Institute Queensland, Griffith University, Gold Coast, Queensland, 4222, Australia.

Background: Critical evaluation of the cost-effectiveness and clinical effectiveness of continuity of midwifery care models for women experiencing complex pregnancy is an important consideration in the review and reform of maternity services. Most studies either focus on women who experience healthy pregnancy or mixed risk samples. These results may not be generalised across the childbearing continuum to women with risk factors. Read More

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http://dx.doi.org/10.1186/s13561-018-0217-3DOI Listing
December 2018
1 Read

Risk prediction models for maternal mortality: A systematic review and meta-analysis.

PLoS One 2018 4;13(12):e0208563. Epub 2018 Dec 4.

Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada.

Purpose: Pregnancy-related critical illness leads to death for 3-14% of affected women. Although identifying patients at risk could facilitate preventive strategies, guide therapy, and help in clinical research, no prior systematic review of this literature exploring the validity of risk prediction models for maternal mortality exists. Therefore, we have systematically reviewed and meta-analyzed risk prediction models for maternal mortality. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0208563PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279047PMC
December 2018
12 Reads

Ursodeoxycholic acid versus placebo in the treatment of women with intrahepatic cholestasis of pregnancy (ICP) to improve perinatal outcomes: protocol for a randomised controlled trial (PITCHES).

Trials 2018 Nov 27;19(1):657. Epub 2018 Nov 27.

University of Nottingham, Nottingham, UK.

Background: Intrahepatic cholestasis of pregnancy (ICP) is the most common liver disorder specific to pregnancy and presents with maternal pruritus, raised concentrations of serum bile acids and abnormal liver function tests. ICP is associated with increased rates of spontaneous and iatrogenic preterm labour, fetal hypoxia, meconium-stained amniotic fluid and intrauterine death. Some clinicians treat ICP with ursodeoxycholic acid (UDCA) to improve maternal pruritus and biochemical abnormalities. Read More

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http://dx.doi.org/10.1186/s13063-018-3018-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260710PMC
November 2018
7 Reads

[Antenatal management in case of preterm premature rupture of membranes before fetal viability: CNGOF Preterm Premature Rupture of Membranes Guidelines].

Authors:
E Azria

Gynecol Obstet Fertil Senol 2018 12 6;46(12):1076-1088. Epub 2018 Nov 6.

Maternité Notre Dame de Bon Secours, groupe hospitalier Paris Saint-Joseph, DHU risques et grossesse, 185, rue Raymond-Losserand, 75014 Paris, France; Inserm UMR 1153, équipe de recherche en épidémiologie obstétricale, périnatale et pédiatrique (EPOPé), centre de recherche épidémiologie et statistique Sorbonne Paris Cité, université Paris Descartes, 75014 Paris, France. Electronic address:

Objectives: To evaluate the maternal, perinatal and long-term prognosis in the event of previable premature rupture of the membranes (PROM) and to specify the interventions likely to reduce the risks and improve the prognosis.

Methods: The PubMed database, the Cochrane Library and the recommendations from the French and foreign obstetrical societies or colleges have been consulted.

Results: Previable PROM is a rare event whose frequency varies from 0. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24687189183027
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http://dx.doi.org/10.1016/j.gofs.2018.10.023DOI Listing
December 2018
10 Reads

The Placenta in Neonatal Encephalopathy: A Case-Control Study.

J Pediatr 2018 11 29;202:77-85.e3. Epub 2018 Jun 29.

Department of Pediatrics and Neurology and Neurosurgery, McGill University, Montreal, Québec, Canada.

Objective: We assessed whether specific histologic placental lesions were associated with risk for neonatal encephalopathy, a strong predictor of death or cerebral palsy.

Study Design: Case-control study of singletons with gestational ages ≥35 weeks. Data were abstracted from a prospectively collected database of consecutive births at a hospital in which placental samples from specified sites are collected and stored for all inborn infants. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00223476183077
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http://dx.doi.org/10.1016/j.jpeds.2018.06.005DOI Listing
November 2018
8 Reads

The incidence of unexpected critical complications in monochorionic diamniotic twin pregnancies according to the interval period between ultrasonographic evaluations.

J Obstet Gynaecol Res 2019 Feb 10;45(2):318-324. Epub 2018 Oct 10.

Department of Maternal Fetal Medicine, Osaka Women's and Children's Hospital, Osaka, Japan.

Aim: This study aimed to evaluate the incidence of unexpected critical complications (UCC) in monochorionic diamniotic (MCDA) twin pregnancies according to ultrasonographic scan interval.

Methods: This retrospective single-center cohort study, conducted between January 2005 and April 2015, investigated the incidence of UCC in patients with MCDA twin pregnancies undergoing weekly ultrasound (Group A) and those undergoing biweekly ultrasound (Group B). We also examined the incidence of predictable critical complications according to ultrasound interval. Read More

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http://doi.wiley.com/10.1111/jog.13827
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http://dx.doi.org/10.1111/jog.13827DOI Listing
February 2019
3 Reads

Persistent inaccuracies in completion of medical certificates of stillbirth: A cross-sectional study.

Paediatr Perinat Epidemiol 2018 09 9;32(5):474-481. Epub 2018 Oct 9.

Faculty of Biology Medicine and Health, Maternal and Fetal Health Research Centre, University of Manchester, Manchester, UK.

Background: The UK Medical Certificate of Stillbirth (MCS) records information relevant to the cause of stillbirth of infants ≥24 weeks' gestation. A cross-sectional audit demonstrated widespread inaccuracies in MCS completion in 2009 in North West England. A repeat study was conducted to assess whether practice had improved following introduction of a regional care pathway. Read More

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http://doi.wiley.com/10.1111/ppe.12501
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http://dx.doi.org/10.1111/ppe.12501DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221058PMC
September 2018
3 Reads

No. 367-2019 Canadian Guideline for Physical Activity throughout Pregnancy.

J Obstet Gynaecol Can 2018 Nov 5;40(11):1528-1537. Epub 2018 Oct 5.

Victoria, BC.

Objective: The objective is to provide guidance for pregnant women, and obstetric care and exercise professionals, on prenatal physical activity.

Outcomes: The outcomes evaluated were maternal, fetal, or neonatal morbidity or fetal mortality during and following pregnancy.

Evidence: Literature was retrieved through searches of Medline, EMBASE, PsycINFO, Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, Scopus and Web of Science Core Collection, CINAHL Plus with Full-text, Child Development & Adolescent Studies, ERIC, Sport Discus, ClinicalTrials. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17012163183056
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http://dx.doi.org/10.1016/j.jogc.2018.07.001DOI Listing
November 2018
18 Reads

Environmental Contaminants and Congenital Heart Defects: A Re-Evaluation of the Evidence.

Authors:
Rachel Nicoll

Int J Environ Res Public Health 2018 09 25;15(10). Epub 2018 Sep 25.

Department of Public Health and Clinical Medicine, Umeå University, SE 901-87 Umeå, Sweden.

Congenital heart defects (CHDs) are a common birth defect of largely unknown etiology, with high fetal and neonatal mortality. A review of CHDs and environmental contaminant exposure found that meta-analyses showed only modest associations for smoking, vehicle exhaust components, disinfectant by-products and proximity to incinerators, with stronger results from the newer, larger and better quality studies masked by the typical absence of effect in older studies. Recent studies of exposure to agricultural pesticides, solvents, metals and landfill sites also showed associations. Read More

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http://www.mdpi.com/1660-4601/15/10/2096
Publisher Site
http://dx.doi.org/10.3390/ijerph15102096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6210579PMC
September 2018
10 Reads

Perinatal death beyond 41 weeks pregnancy: an evaluation of causes and substandard care factors as identified in perinatal audit in the Netherlands.

BMC Pregnancy Childbirth 2018 Sep 20;18(1):380. Epub 2018 Sep 20.

Department of Obstetrics and Gynaecology, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6523, GA, Nijmegen, the Netherlands.

Background: Late- and postterm pregnancy are associated with adverse perinatal outcomes, like perinatal death. We evaluated causes of death and substandard care factors (SSFs) in term and postterm perinatal death.

Methods: We used data from the Perinatal Audit Registry of the Netherlands (PARS). Read More

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http://dx.doi.org/10.1186/s12884-018-1973-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149052PMC
September 2018
12 Reads

Ethical Issues in Intrauterine Myelomeningocele Surgery.

New Bioeth 2018 Nov 20;24(3):249-257. Epub 2018 Sep 20.

c Medical Student, Facultad de Ciencias Biomédicas , Universidad Austral , Buenos Aires , Argentina.

Intrauterine surgery shows that the prognosis of neonates with myelomeningocele (MMC) has improved, both in survival and in quality of life. In order to study the current efficacy of intrauterine surgery for MMC and to make an ethical analysis of its proportionality, we conducted a PubMed search using the keywords "myelomeningocele", "intrauterine surgery", "MOMS", and "trial". Thirty-eight articles were found. Read More

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http://dx.doi.org/10.1080/20502877.2018.1521499DOI Listing
November 2018
2 Reads

Evolving Decisions: Perspectives of Active and Athletic Individuals with Inherited Heart Disease Who Exercise Against Recommendations.

J Genet Couns 2018 Sep 15. Epub 2018 Sep 15.

Stanford Center for Inherited Cardiovascular Disease, Stanford Healthcare, Stanford, CA, USA.

Individuals with hypertrophic cardiomyopathy (HCM) and long QT syndrome (LQTS) are advised to avoid certain forms of exercise to reduce their risk of sudden death. Cardiovascular genetic counselors facilitate both adaptation to, and decision-making about, these exercise recommendations. This study describes decision-making and experiences of active adults who exercise above physicians' recommendations. Read More

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http://dx.doi.org/10.1007/s10897-018-0297-6DOI Listing
September 2018
6 Reads

New terminology for adverse events of fetal therapy: Re-evaluation of the thoraco-amniotic shunting in a Japanese study.

J Obstet Gynaecol Res 2019 Feb 6;45(2):251-257. Epub 2018 Sep 6.

Department of Obstetrics and Gynecology, Toho University Omori Medical Center, Tokyo, Japan.

Aim: Since fetal therapy has been newly developed, objective evaluation of adverse events (AE), all harmful events that are not always related to the procedures, has not yet been adequately reported. We established new terminology and tried to re-evaluate it based on the Japanese prospective thoraco-amniotic shunting (TAS) study.

Methods: From the literature, all complications that occurred with all fetal therapies were identified as a basis for developing the terminology. Read More

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http://dx.doi.org/10.1111/jog.13804DOI Listing
February 2019
7 Reads

Admission cardiotocography versus intermittent auscultation of the fetal heart in low-risk pregnancy during evaluation for possible labour admission - a multicentre randomised trial: the ADCAR trial.

BJOG 2019 Jan 19;126(1):114-121. Epub 2018 Sep 19.

School of Nursing and Midwifery, National University of Ireland, Galway, Ireland.

Objective: To assess the effect of admission cardiotocography (ACTG) versus intermittent auscultation (IA) of the fetal heart (FH) in low-risk pregnancy during assessment for possible labour on caesarean section rates.

Design: A parallel multicentre randomised trial.

Setting: Three maternity units in the Republic of Ireland. Read More

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http://doi.wiley.com/10.1111/1471-0528.15448
Publisher Site
http://dx.doi.org/10.1111/1471-0528.15448DOI Listing
January 2019
17 Reads

Urgent Cesarean Delivery Following a Spontaneous Coronary Artery Dissection.

Am J Case Rep 2018 Aug 15;19:956-961. Epub 2018 Aug 15.

Clinic of Cardiovascular Disease, San Martino Policlinic Hospital, University of Genova, Genova, Italy.

BACKGROUND Spontaneous coronary artery dissection is the most common etiology of pregnancy-associated myocardial infarction. It is characterized by high rates of maternal morbidity and mortality and may cause fetal complications and death as well. CASE REPORT A 44-year-old female (G2P1) suffered from pregnancy-related spontaneous coronary artery dissection with dissection of distal left anterior descending coronary artery. Read More

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http://dx.doi.org/10.12659/AJCR.909821DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6106692PMC
August 2018
2 Reads

Radiographic evaluation of the pregnant trauma patient: What are We willing to miss?

Eur J Obstet Gynecol Reprod Biol 2018 Sep 28;228:325-328. Epub 2018 Jun 28.

Ohio Health Grant Medical Center, Columbus, Ohio, United States.

Objective: Trauma is the leading cause of non-obstetrical causes of death in pregnant patients. The use of radiographic imaging for evaluation in the trauma bay is a controversial topic. However, in some cases the benefits of using radiographic imaging to ensure maternal survival outweigh the risks of radiation exposure to the fetus. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2018.06.039DOI Listing
September 2018
2 Reads

Decreasing use of autopsy for stillbirths and infant deaths: missed opportunity.

J Perinatol 2018 Oct 3;38(10):1414-1419. Epub 2018 Aug 3.

Department of Pediatrics, University of Toronto, Mount Sinai Hospital, 600 University Avenue, Toronto, M5G 1X5, Canada.

Objective: We assessed whether the tendency towards decreasing use of fetal and infant autopsy was associated with a greater proportion of deaths in which the cause is never found.

Study Design: We computed autopsy rates over time for 13,466 stillbirths and 16,880 infant deaths in Quebec, Canada, 1981-2015. We assessed the proportion of deaths with an undetermined cause and determined the relationship with non-autopsy over time. Read More

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http://www.nature.com/articles/s41372-018-0191-y
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http://dx.doi.org/10.1038/s41372-018-0191-yDOI Listing
October 2018
13 Reads

Environmental and individual exposure and the risk of congenital anomalies: a review of recent epidemiological evidence.

Epidemiol Prev 2018 May-Aug;42(3-4 Suppl 1):1-34

Unit of Environmental Epidemiology and Disease Registries, Institute of Clinical Physiology, National Research Council, Pisa (Italy).

Introduction: Congenital anomalies (CAs) represent one of the main cause of foetal death, infant mortality and morbidity, and long-term disability. CAs have been object of systematic registration activity for a long-time in many geographical areas in Europe and worldwide. CAs are often associated with disabilities of different types and severity, including the developed Countries worldwide. Read More

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http://dx.doi.org/10.19191/EP18.3-4.S1.P001.057DOI Listing
January 2019
3 Reads

Coupling a reproductive function model to a productive function model to simulate lifetime performance in dairy cows.

Animal 2018 Jul 24:1-10. Epub 2018 Jul 24.

2Université Clermont Auvergne,UMR 1213 Herbivores,VetAgro Sup,INRA,63122 Saint-Genès-Champanelle,France.

Reproductive success is a key component of lifetime performance in dairy cows but is difficult to predict due to interactions with productive function. Accordingly, this study introduces a dynamic model to simulate the productive and reproductive performance of a cow during her lifetime. The cow model consists of an existing productive function model (GARUNS) which is coupled to a new reproductive function model (RFM). Read More

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http://dx.doi.org/10.1017/S1751731118001830DOI Listing

Implementing a Protocol to Optimize Detection of Chromosome Abnormalities in Cases of Miscarriage or Stillbirth at a Midwestern Teaching Hospital.

Perm J 2018 07;22

Clinical Assistant Professor in Obstetrics and Gynecology at the University of Kansas School of Medicine in Wichita.

Context: Results from chromosome testing after spontaneous abortion (SAB) or intrauterine fetal demise (IUFD) are useful in patient counseling; however, results can be inconclusive when cell cultures for chromosomes are unable to grow from products of conception. Chromosomal microarray analysis (CMA) can analyze DNA from nonviable fetal tissue.

Objective: To examine whether establishing a genetic testing protocol for karyotype and CMA on SAB and IUFD tissues increases diagnostic yield. Read More

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http://dx.doi.org/10.7812/TPP/17-204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047853PMC
July 2018
12 Reads

Cost-effectiveness of diagnostic tests for threatened preterm labor in singleton pregnancy in France.

Cost Eff Resour Alloc 2018 14;16:21. Epub 2018 Jun 14.

Clinical Epidemiology Unit, Inserm, CIC 1432, Dijon, France.

Background: Previous studies have showed that the early diagnosis of threatened preterm labor decreases neonatal morbidity and mortality, avoids maternal morbidity induced by antepartum bed rest and unnecessary treatment, and reduces costs. Although there are many diagnostic tests, none is clearly recommended by international guidelines. The aim of our study was to compare seven diagnostic methods in terms of effectiveness and cost using a decision analysis model in singleton pregnancy presenting threatened preterm labor, between 24 and 34 weeks of gestation. Read More

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http://dx.doi.org/10.1186/s12962-018-0106-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003030PMC
June 2018
8 Reads

Does progesterone prophylaxis to prevent preterm labour improve outcome? A randomised double-blind placebo-controlled trial (OPPTIMUM).

Health Technol Assess 2018 06;22(35):1-304

Centre for Healthcare Randomised Trials, Health Services Research Unit, University of Aberdeen, Aberdeen, UK.

Background: Progesterone prophylaxis is widely used to prevent preterm birth but is not licensed and there is little information on long-term outcome.

Objective: To determine the effect of progesterone prophylaxis in women at high risk of preterm birth on obstetric, neonatal and childhood outcomes.

Design: Double-blind, randomised placebo-controlled trial. Read More

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http://dx.doi.org/10.3310/hta22350DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036405PMC
June 2018
4 Reads

A shortened study design for embryo-fetal development studies in the minipig.

Reprod Toxicol 2018 09 22;80:35-43. Epub 2018 Jun 22.

Ellegaard Göttingen Minipigs, Dalmose, Denmark.

The minipig is accepted from scientific and regulatory perspectives for the safety evaluation of drug candidates on embryo-fetal development. The relative size and the duration of gestation (112-115 days) in the minipig is, however, considered a drawback compared with routine smaller species. We evaluated if study duration and cost could be optimized without impacting scientific validity by performing all terminal procedures around mid-gestation (60 days). Read More

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http://dx.doi.org/10.1016/j.reprotox.2018.06.009DOI Listing
September 2018
3 Reads

Stillbirth and perinatal care: Are professionals trained to address parents' needs?

Midwifery 2018 Sep 7;64:53-59. Epub 2018 Jun 7.

CiaoLapo Onlus, Charity for Stillbirth and Perinatal Grief Support, Prato, Italy; International Stillbirth Alliance, Bristol, UK; Department of Neurosciences, Psychology, Drug Research and Child Health (NeuroFarBa), University of Florence, Viale Pieraccini 6, 50139 Firenze, Italy. Electronic address:

Objective: To assess current practices of health care providers (HCPs) caring for women experiencing a stillbirth and to explore their needs for training to better support bereaved families.

Design: Nationwide cross-sectional survey. The main outcome measures were the evaluation of HCPs cognition, emotions and behaviours with regard to the care of women with a stillbirth care, as well as their compliance with international guidelines. Read More

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http://dx.doi.org/10.1016/j.midw.2018.05.008DOI Listing
September 2018
6 Reads

The Possibility of Postmortem Magnetic Resonance Imaging for the Diagnostics of Lung Hypoplasia.

Bull Exp Biol Med 2018 Jun 20;165(2):288-291. Epub 2018 Jun 20.

V. I. Kulakov National Medical Research Centre of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia.

We explored the possibility of using postmortem MRI for the diagnostics of lung hypoplasia associated with innate diaphragmatic hernia in neonates. The main experimental group consisted of 17 newborns with innate diaphragmatic hernia including 10 non-operated newborns and 7 newborns died after surgery for innate diaphragmatic hernia. It was demonstrated that postmortem MRI allows objective quantitative assessment of the absolute and relative dimensions of the lungs in the thoracic cavity and thereby reveals their hypoplasia, which contributes to the determination of tanatogenesis. Read More

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http://dx.doi.org/10.1007/s10517-018-4150-6DOI Listing
June 2018
6 Reads

Intraamniotic Zika virus inoculation of pregnant rhesus macaques produces fetal neurologic disease.

Nat Commun 2018 06 20;9(1):2414. Epub 2018 Jun 20.

California National Primate Research Center, University of California, 1 Shields Avenue, Davis, CA, 95616, USA.

Zika virus (ZIKV) infection of pregnant women can cause fetal microcephaly and other neurologic defects. We describe the development of a non-human primate model to better understand fetal pathogenesis. To reliably induce fetal infection at defined times, four pregnant rhesus macaques are inoculated intravenously and intraamniotically with ZIKV at gestational day (GD) 41, 50, 64, or 90, corresponding to first and second trimester of gestation. Read More

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http://dx.doi.org/10.1038/s41467-018-04777-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010452PMC
June 2018
28 Reads
10.742 Impact Factor

Smoking ban and health at birth: Evidence from Hungary.

Econ Hum Biol 2018 09 13;30:37-47. Epub 2018 Jun 13.

Institute for Sociology, Centre for Social Sciences, Hungarian Academy of Sciences, Tóth Kálmán u. 4., 1097 Budapest, Hungary; MTA-ELTE Peripato Comparative Social Dynamics Research Group, Pázmány Péter sétány 1/A, 1117 Budapest, Hungary. Electronic address:

In 2012, smoking restrictions were extended to hospitality venues in Hungary. Women working in bars and restaurants were primarily affected by the intervention. In this research, we analyze the effect of this smoking ban on the outcomes of their pregnancies. Read More

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http://dx.doi.org/10.1016/j.ehb.2018.05.003DOI Listing
September 2018

Mifepristone Pretreatment for the Medical Management of Early Pregnancy Loss.

N Engl J Med 2018 06;378(23):2161-2170

From the Pregnancy Early Access Center (PEACE), Division of Family Planning (C.A.S., S.S.), Department of Obstetrics and Gynecology (C.A.S., S.S., K.T.B.), University of Pennsylvania, Philadelphia; the Department of Public Health Sciences, University of Virginia, Charlottesville (S.J.R.); the Department of Obstetrics and Gynecology, University of California, Davis, Sacramento (M.D.C.); and the Department of Obstetrics and Gynecology, Montefiore Hospital and Albert Einstein College of Medicine, Bronx, NY (J.A.).

Background: Medical management of early pregnancy loss is an alternative to uterine aspiration, but standard medical treatment with misoprostol commonly results in treatment failure. We compared the efficacy and safety of pretreatment with mifepristone followed by treatment with misoprostol with the efficacy and safety of misoprostol use alone for the management of early pregnancy loss.

Methods: We randomly assigned 300 women who had an anembryonic gestation or in whom embryonic or fetal death was confirmed to receive pretreatment with 200 mg of mifepristone, administered orally, followed by 800 μg of misoprostol, administered vaginally (mifepristone-pretreatment group), or 800 μg of misoprostol alone, administered vaginally (misoprostol-alone group). Read More

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http://www.nejm.org/doi/10.1056/NEJMoa1715726
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http://dx.doi.org/10.1056/NEJMoa1715726DOI Listing
June 2018
16 Reads

Reducing stillbirths in Ethiopia: Results of an intervention programme.

PLoS One 2018 30;13(5):e0197708. Epub 2018 May 30.

Centre for International Health, University of Bergen, Bergen, Norway.

Previous studies from South Ethiopia have shown that interventions that focus on intrapartum care substantially reduce maternal mortality and there is a need to operationalize health packages that could reduce stillbirths. The aim of this paper is to evaluate if a programme that aimed to improve maternal health, and mainly focusing on strengthening intrapartum care, also would reduce the number of stillbirths, and to estimate if there are other indicators that explains high stillbirth rates. Our study used a "continuum of care" approach and focussed on providing essential antenatal and obstetric services in communities through health extension workers, at antenatal and health facility services. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0197708PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976193PMC
December 2018
1 Read
3.230 Impact Factor

Maternal and fetal outcomes in pregnant women with heart failure.

Heart 2018 Dec 25;104(23):1949-1954. Epub 2018 May 25.

Division of Cardiology, Kaiser Permanente Los Angeles Medical Center, Los Angeles, California, USA.

Objectives: The goal of this study is to report the prevalence, aetiology and clinical outcome of pregnant women with heart failure.

Methods: This is a retrospective community-based cohort study that included pregnant women in the Kaiser Permanente Health System between 2003 and 2014. Women with heart failure were identified using International Classification of Disease, Ninth Revision codes. Read More

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http://dx.doi.org/10.1136/heartjnl-2018-313156DOI Listing
December 2018
3 Reads
5.595 Impact Factor

Listeria, Then and Now: A Call to Reevaluate Patient Teaching Based on Analysis of US Federal Databases, 1998-2016.

J Midwifery Womens Health 2018 May 24;63(3):301-308. Epub 2018 May 24.

Introduction: Listeria monocytogenes is a foodborne pathogen capable of crossing the placental-fetal barrier; infection with the bacterium causes listeriosis. An exposed fetus may suffer blindness, neurological damage including meningitis, or even death. The adverse consequences of listeriosis place the infection on the federally reportable disease list. Read More

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http://dx.doi.org/10.1111/jmwh.12757DOI Listing
May 2018
2 Reads

Dutch guideline for clinical foetal-neonatal and paediatric post-mortem radiology, including a review of literature.

Eur J Pediatr 2018 Jun 19;177(6):791-803. Epub 2018 Apr 19.

Department of Radiology, Radboud University Medical Center, Nijmegen, The Netherlands.

Clinical post-mortem radiology is a relatively new field of expertise and not common practice in most hospitals yet. With the declining numbers of autopsies and increasing demand for quality control of clinical care, post-mortem radiology can offer a solution, or at least be complementary. A working group consisting of radiologists, pathologists and other clinical medical specialists reviewed and evaluated the literature on the diagnostic value of post-mortem conventional radiography (CR), ultrasonography, computed tomography (PMCT), magnetic resonance imaging (PMMRI), and minimally invasive autopsy (MIA). Read More

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http://dx.doi.org/10.1007/s00431-018-3135-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5958158PMC
June 2018
7 Reads

Neural Tube Defects in Embryonic Life: Lessons Learned From 340 Early Pregnancy Failures.

J Ultrasound Med 2018 Dec 17;37(12):2841-2847. Epub 2018 Apr 17.

Division of Prenatal Medicine, Department of Obstetrics and Gynecology, University of Schleswig-Holstein, Luebeck, Germany.

Objectives: The aim of this study was to evaluate the feasibility of sonographic assessment of the embryonic/fetal neural tube in nonviable pregnancies and to determine the defect incidence.

Methods: Prospective analysis of transvaginally acquired 3-dimensional (3D) multiplanar and 3D surface-rendered volume sets of 340 cases of missed abortion between March 2010 and September 2015 was performed. Data regarding karyotype and postmortem examination as well as demographic features and the outcomes of subsequent pregnancies were evaluated. Read More

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http://dx.doi.org/10.1002/jum.14642DOI Listing
December 2018
5 Reads

Outcome reporting across randomized trials and observational studies evaluating treatments for twin-twin transfusion syndrome: systematic review.

Ultrasound Obstet Gynecol 2018 Nov 24;52(5):577-585. Epub 2018 Sep 24.

Vascular Biology Research Centre, Molecular and Clinical Sciences Research Institute, St George's University of London, London, UK.

Objective: Twin-twin transfusion syndrome (TTTS) is associated with significant mortality and morbidity. Potential treatments for the condition require robust evaluation. The aim of this study was to evaluate outcome reporting across observational studies and randomized controlled trials assessing treatments for TTTS. Read More

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http://dx.doi.org/10.1002/uog.19068DOI Listing
November 2018
12 Reads

Fetal primary hydrothorax with spontaneous resolution.

Case Rep Womens Health 2017 Jul 10;15:6-7. Epub 2017 Jun 10.

Department of Obstetrics and Gynecology, Unidade Local de Saúde do Alto Minho (ULSAM), Viana do Castelo, Portugal.

Fetal primary hydrothorax is a rare congenital anomaly with an estimated incidence of 1:10.000-15.000 pregnancies, with an unpredictable clinical course, ranging from spontaneous resolution to fetal death. Read More

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http://dx.doi.org/10.1016/j.crwh.2017.06.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5842973PMC
July 2017
5 Reads

Histologic Changes Associated With Placental Separation in Gilts Infected with Porcine Reproductive and Respiratory Syndrome Virus.

Vet Pathol 2018 07 22;55(4):521-530. Epub 2018 Mar 22.

1 Department of Large Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK, Canada.

The placenta is a vital organ providing the developing fetus with nutrient and gas exchange, thermoregulation, and waste elimination necessary for fetal development, as well as producing hormones to maintain pregnancy. It is hypothesized that fetal pig death in porcine reproductive and respiratory syndrome may be attributed to pathology of the maternal-fetal interface leading to premature placental separation. This study was designed to evaluate the chronologic progression of porcine reproductive and respiratory syndrome virus (PRRSV)-induced lesions at the maternal-fetal interface, with particular focus on placental separation in experimentally challenged third-trimester gilts. Read More

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http://dx.doi.org/10.1177/0300985818765067DOI Listing
July 2018
8 Reads

Comparison of umbilical artery Doppler and non-stress test in assessment of fetal well-being in gestational diabetes mellitus: A prospective cohort study.

Electron Physician 2017 Dec 25;9(12):6087-6093. Epub 2017 Dec 25.

Ph.D. of Reproductive Health, Assistant professor, Department of Midwifery, School of Nursing & Midwifery, Sabzevar University of Medical Sciences, Sabzevar, Iran.

Background: Gestational diabetes mellitus (GDM) is one of the most common medical complications of pregnancy and is related to poor perinatal outcomes. Reduction of neonatal complications of GDM is feasible by assessment of fetal well-being. Both fetal Doppler and NST are used for the screening of high-risk pregnancies. Read More

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http://dx.doi.org/10.19082/6087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843438PMC
December 2017
7 Reads

Increased Risk of Pregnancy Complications After Stroke: The FUTURE Study (Follow-Up of Transient Ischemic Attack and Stroke Patients and Unelucidated Risk Factor Evaluation).

Stroke 2018 Apr 6;49(4):877-883. Epub 2018 Mar 6.

From the Department of Neurology, Donders Institute for Brain, Cognition, and Behaviour, Center for Neuroscience (M.E.v.A., M.d.V., R.M.A., H.S., E.J.v.D., F.-E.d.L.) and Department of Cardiology (M.J.v.d.V.), Radboud University Nijmegen Medical Center, the Netherlands; Center for Neurology and Neurorehabilitation, State Hospital, Switzerland (N.A.M.M.M.); Department of Neurology, St. Elisabeth Hospital, the Netherlands (N.E.S.); Division of Woman and Baby, Birth Center, University Utrecht Medical Center, the Netherlands (R.d.H.); and German Center for Neurodegenerative Diseases (DZNE), Population Health Sciences, Bonn, Germany (L.C.A.R.-J.).

Background And Purpose: The study goal was to investigate the prevalence of pregnancy complications and pregnancy loss in women before, during, and after young ischemic stroke/transient ischemic attack.

Methods: In the FUTURE study (Follow-Up of Transient Ischemic Attack and Stroke Patients and Unelucidated Risk Factor Evaluation), a prospective young stroke study, we assessed the occurrence of pregnancy, miscarriages, and pregnancy complications in 223 women aged 18 to 50 years with a first-ever ischemic stroke/transient ischemic attack. Pregnancy complications (gestational hypertension, diabetes mellitus, preeclampsia, and hemolysis, elevated liver enzymes, low platelet count syndrome) were assessed before, during, and after stroke using standardized questionnaires. Read More

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http://dx.doi.org/10.1161/STROKEAHA.117.019904DOI Listing
April 2018
17 Reads

Mechanistic Evaluation of Roots Potential as an Antidiabetic Folk Medicinal Plant.

Pharmacogn Mag 2018 Jan 31;13(Suppl 4):S852-S859. Epub 2018 Jan 31.

Pharmaceutical Sciences Research Center, School of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Objective: has been used as a traditional herbal medicine for treating . The aim of this study is to investigate the antidiabetic mechanisms of infusion (INF) extract of and discovering the active extract for the first time.

Materials And Methods: Six different extracts of were prepared using five different solvents (ethanol, -hexane, acetone, ethanol:water (1:1 v/v), and water). Read More

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http://dx.doi.org/10.4103/pm.pm_162_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5822511PMC
January 2018
7 Reads

Evaluation of stillbirth.

Curr Opin Obstet Gynecol 2018 04;30(2):130-135

Department of Obstetrics & Gynecology, University of Utah School of Medicine, Salt Lake City, Utah, USA.

Purpose Of Review: To review current evidence regarding the most useful tests for evaluation of potential causes of stillbirth.

Recent Findings: Stillbirth remains one of the most devastating obstetric complications. Recent advances include work investigating the highest yield diagnostic tests for determining a cause of death in stillbirths. Read More

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http://dx.doi.org/10.1097/GCO.0000000000000441DOI Listing
April 2018
1 Read

Trauma in pregnancy.

Semin Perinatol 2018 02;42(1):13-20

Department of Surgery, University of Arizona College of Medicine, Banner University Medical Center, Phoenix, AZ.

Trauma is the leading non-obstetric cause of death during pregnancy and approximately 6-8% of all pregnancies are complicated by injury, both accidental and intentional. The initial evaluation and management of the injured pregnant patient often requires a multidisciplinary, collaborative team to provide the optimal outcome for both mother and fetus. It is important to recognize that even minor mechanisms of injury may result in poor outcomes for both fetus and mother. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01460005173012
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http://dx.doi.org/10.1053/j.semperi.2017.11.004DOI Listing
February 2018
4 Reads

What may cause fetus loss from acute pancreatitis in pregnancy: Analysis of 54 cases.

Medicine (Baltimore) 2018 Feb;97(7):e9755

Department of Gastroenterology, the Second Hospital of Anhui Medical University, Hefei, China.

Acute pancreatitis in pregnancy (APIP) poses a serious threat to the mother and her fetus, and might lead to fetal loss including miscarriage and stillbirth in certain patients. We sought to identify possible factors that affect fetal distress and evaluated outcomes of patients with APIP.We retrospectively reviewed clinical records of 54 pregnant women with APIP, who were treated at 2 tertiary clinical centers over a 6-year period. Read More

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http://Insights.ovid.com/crossref?an=00005792-201802160-0001
Publisher Site
http://dx.doi.org/10.1097/MD.0000000000009755DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839860PMC
February 2018
13 Reads

Clinical presentation, management, and postnatal outcomes of fetal tachyarrhythmias: A 10-year single-center experience.

Ann Pediatr Cardiol 2018 Jan-Apr;11(1):34-39

Department of Pediatric Cardiology, Amrita School of Medicine, Amrita Institute of Medical Sciences, Kochi, Kerala, India.

Background: Limited information is available regarding the prevalence and outcomes of fetal tachyarrhythmias from the developing countries.

Aims: This study aims to report referral patterns, management protocols, and pregnancy outcomes of fetuses with tachyarrhythmias reporting to a single center in South India.

Methods: All fetuses with documented sustained fetal tachyarrhythmia during the study period (2008-2017) were included. Read More

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http://dx.doi.org/10.4103/apc.APC_102_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5803975PMC
February 2018
2 Reads