2,619 results match your criteria Evaluation of Fetal Death


Development of the Sepsis-Associated Adverse Outcomes in Pregnancy Score.

Am J Perinatol 2022 Jun 24. Epub 2022 Jun 24.

Obstetrics & Gynecology, Department of Obstetrics, Gynecology, and Reproductive Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, United States.

Objective: To develop and evaluate a scoring system-called Sepsis-Associated Adverse Outcomes in Pregnancy (SAAP) Score-to identify individuals with maternal infection that have composite maternal adverse outcomes (CMAO).

Study Design: Using ICD codes, we identified pregnant and postpartum (up to 6 weeks after birth) individuals admitted at our center with a primary diagnosis of infection. The primary outcome was CMAO, which included any of the following: maternal intensive care unit admission, surgical intervention, vasopressor use, acute respiratory distress syndrome, pulmonary edema, mechanical ventilation, high flow nasal cannula, disseminated intravascular coagulation, dialysis, organ failure, venous thromboembolism, or maternal death. Read More

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Evaluation of the Growth Assessment Protocol (GAP) for antenatal detection of small for gestational age: The DESiGN cluster randomised trial.

PLoS Med 2022 Jun 21;19(6):e1004004. Epub 2022 Jun 21.

Department of Women and Children's Health, King's College London, London, United Kingdom.

Background: Antenatal detection and management of small for gestational age (SGA) is a strategy to reduce stillbirth. Large observational studies provide conflicting results on the effect of the Growth Assessment Protocol (GAP) in relation to detection of SGA and reduction of stillbirth; to the best of our knowledge, there are no reported randomised control trials. Our aim was to determine if GAP improves antenatal detection of SGA compared to standard care. Read More

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Worth the paper it's written on? A cross-sectional study of Medical Certificate of Stillbirth accuracy in the UK.

Int J Epidemiol 2022 Jun 20. Epub 2022 Jun 20.

United Kingdom Audit and Research Collaborative in Obstetrics and Gynaecology, UK.

Background: The Medical Certificate of Stillbirth (MCS) records data about a baby's death after 24 weeks of gestation but before birth. Major errors that could alter interpretation of the MCS were widespread in two UK-based regional studies.

Methods: A multicentre evaluation was conducted, examining MCS issued 1 January 2018 to 31 December 2018 in 76 UK obstetric units. Read More

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Safety of tetanus, diphtheria, acellular pertussis (Tdap) vaccination during pregnancy.

Vaccine 2022 Jun 15. Epub 2022 Jun 15.

Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, CA, USA.

The objective of this study was to evaluate the safety of prenatal tetanus, diphtheria, acellular pertussis (Tdap) vaccination. This cohort study was conducted among pregnant members at Kaiser Permanente Southern California (KPSC). The exposed cohort consisted of women who received Tdap vaccine on or after the 27th week of pregnancy between January 2018 and January 2019. Read More

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The causes of stillbirths in south Asia: results from a prospective study in India and Pakistan (PURPOSe).

Lancet Glob Health 2022 Jul;10(7):e970-e977

Department of Obstetrics and Gynecology, Columbia University, New York, NY, USA.

Background: South Asia contributes more than a third of all global stillbirths, yet the causes remain largely unstudied in this region. New investigations, including novel assessments of placental and fetal tissues, facilitate more precise determination of the underlying causes of stillbirth. We sought to assess underlying and contributing causes of stillbirth from settings in India and Pakistan. Read More

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Fetal periventricular pseudocysts: is MRI evaluation needed? What is the long-term neurodevelopmental outcome? Systematic review and meta-analysis.

Arch Gynecol Obstet 2022 Jun 8. Epub 2022 Jun 8.

Department of Ultrasound, West China Second University Hospital, Sichuan University, Chengdu, China.

Objective: To explore the value of magnetic resonance imaging (MRI) in fetuses with periventricular pseudocysts (PVPC) and the neurodevelopmental outcomes of these fetuses via meta-analysis.

Methods: MEDLINE and EMBASE database were searched for studies reporting on the MRI assessment of fetuses diagnosed with PVPC on neurosonography. The neurosonography was conducted according to the International Society of Ultrasound in Obstetrics and Gynecology (ISUOG) guidelines or standard axial, coronal and sagittal planes for advanced central nervous system (CNS) assessment. Read More

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Predictive value of prenatal ultrasound in foetal intraabdominal cystic lesions and evaluation of perinatal outcomes: a single-centre study results.

J Obstet Gynaecol 2022 Jun 2:1-6. Epub 2022 Jun 2.

Department of Maternal and Fetal Medicine, Basaksehir Cam and Sakura City Hospital, Istanbul, Turkey.

The prenatal diagnosis of intra-abdominal cystic lesions is relatively common and it can be due to a wide variety of clinical conditions. The aims of this study were to determine the accuracy of the prenatal ultrasound in identifying the aetiology of foetal intra-abdominal cysts and to describe the prenatal and postnatal outcomes.This study is a retrospective analysis of 137 foetuses diagnosed with intraabdominal cysts during the prenatal period, except those originating from the urinary system, conducted from April 2015 to August 2018. Read More

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[Early risk factors for death in neonates with persistent pulmonary hypertension of the newborn treated with inhaled nitric oxide].

Zhongguo Dang Dai Er Ke Za Zhi 2022 May;24(5):507-513

Department of Neonatology, Children's Hospital of Nanjing Medical University, Nanjing 210008, China.

Objectives: To evaluate the early risk factors for death in neonates with persistent pulmonary hypertension of the newborn (PPHN) treated with inhaled nitric oxide (iNO).

Methods: A retrospective analysis was performed on 105 infants with PPHN (gestational age ≥34 weeks and age <7 days on admission) who received iNO treatment in the Department of Neonatology, Children's Hospital of Nanjing Medical University, from July 2017 to March 2021. Related general information and clinical data were collected. Read More

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Population birth outcomes in 2020 and experiences of expectant mothers during the COVID-19 pandemic: A 'born in Wales' mixed methods study using routine data.

PLoS One 2022 24;17(5):e0267176. Epub 2022 May 24.

National Centre for Population Health and Wellbeing Research, Swansea University Medical School, Swansea, Wales, United Kingdom.

Background: Pregnancy can be a stressful time and the COVID-19 pandemic has affected all aspects of life. This study aims to investigate the pandemic impact on pregnancy experience, rates of primary childhood immunisations and the differences in birth outcomes in during 2020 to those of previous years.

Methods: Self-reported pregnancy experience: 215 expectant mothers (aged 16+) in Wales completed an online survey about their experiences of pregnancy during the pandemic. Read More

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Preliminary evaluation of the mechanism underlying vulnerability/resistance to methylmercury toxicity by comparative gene expression profiling of rat primary cultured cerebrocortical and hippocampal neurons.

J Toxicol Sci 2022 ;47(5):211-219

Department of Basic Medical Sciences, National Institute for Minamata Disease.

Methylmercury (MeHg), an environmentally toxic substance, causes site-specific neuronal cell death; while MeHg exposure causes death in cerebrocortical neurons, interestingly, it does not in hippocampal neurons, which are generally considered to be vulnerable to toxic substances. This phenomenon of site-specific neuronal cell death can be reproduced in animal experiments; however, the mechanism underlying the resistance of hippocampal neurons to MeHg toxicity has not been clarified. In this study, we comparatively analyzed the response to MeHg exposure in terms of viability and the expression characteristics of primary cultured cerebrocortical neurons and hippocampal neurons derived from fetal rat brain. Read More

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Effect of adolescent pregnancy on child mortality in 46 countries.

BMJ Glob Health 2022 05;7(5)

University of Washington, Institute for Health Metrics and Evaluation, Seattle, Washington, USA.

Introduction: Adolescent pregnancy is a known health risk to mother and child. Statements and reports of health outcomes typically group mothers under 20 years old together. Few studies examined this risk at a finer age resolution, none of them comprehensively, and with differing results. Read More

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Group B streptococcus infection during pregnancy and infancy: estimates of regional and global burden.

Lancet Glob Health 2022 06 28;10(6):e807-e819. Epub 2022 Apr 28.

Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK; Maternal, Adolescent, Reproductive & Child Health Centre, London School of Hygiene & Tropical Medicine, London, UK.

Background: Group B streptococcus (GBS) colonisation during pregnancy can lead to invasive GBS disease (iGBS) in infants, including meningitis or sepsis, with a high mortality risk. Other outcomes include stillbirths, maternal infections, and prematurity. There are data gaps, notably regarding neurodevelopmental impairment (NDI), especially after iGBS sepsis, which have limited previous global estimates. Read More

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Post-authorization surveillance of adverse events following COVID-19 vaccines in pregnant persons in the vaccine adverse event reporting system (VAERS), December 2020 - October 2021.

Vaccine 2022 May 12;40(24):3389-3394. Epub 2022 Apr 12.

Division of Birth Defects and Infant Disorders, National Center on Birth Defects and Developmental Disabilities, CDC.

Background: Pregnant persons are at increased risk of severe illness from COVID-19 infection, including intensive care unit admission, mechanical ventilation, and death compared with non-pregnant persons of reproductive age. Limited data are available on the safety of COVID-19 vaccines administered during and around the time of pregnancy.

Objective: To evaluate and summarize reports to the Vaccine Adverse Event Reporting System (VAERS), a national spontaneous reporting system, in pregnant persons who received a COVID-19 vaccine to assess for potential vaccine safety problems. Read More

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Evaluation of neural tube defects from 2014 to 2019 in Turkey.

BMC Pregnancy Childbirth 2022 Apr 19;22(1):340. Epub 2022 Apr 19.

Ministry of Health, General Directorate of Public Health, Ankara, Turkey.

Objective: The aim of this study is to determine the frequency of neural tube defects (NTDs) and to examine the epidemiological characteristics of NTD related deaths in Turkey.

Methods: This nationwide descriptive study was included NTD related infant deaths, termination of pregnancy for fetal anomaly (ToPFA) and stillbirth cases registered in Death Notification System between 2014 and 2019, and patients diagnosed with NTD in the 2018 birth cohort.

Findings: In the 2018 birth cohort, there were 3475 cases of NTD at birth (27. Read More

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Death and severe morbidity in isolated periviable small-for-gestational-age fetuses.

BJOG 2022 Apr 19. Epub 2022 Apr 19.

Barcelona Centre for Maternal-Fetal and Neonatal Medicine (Hospital Clínic and Hospital Sant Joan de Deu), IDIBAPS (Institut D'Investigacions Biomediques August Pi i Sunyer), University of Barcelona, and Centre for Biomedical Research on Rare Diseases (CIBER-ER), Barcelona, Spain.

Objective: This study aims to predict perinatal death or severe sequelae in isolated small-for-gestational-age fetuses, diagnosed at a periviable gestational age, based on ultrasound and Doppler parameters at diagnosis.

Design: Observational study.

Setting: A tertiary perinatal centre. Read More

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Beyond research: improved perinatal care through scale-up of a Moyo fetal heart rate monitor coupled with simulation training in northern Tanzania for helping babies breathe.

BMC Pediatr 2022 04 11;22(1):191. Epub 2022 Apr 11.

Research Centre, Haydom Lutheran Hospital, P.O BOX 9000, Haydom, Mbulu, Tanzania.

Background: The purpose of this project was to improve perinatal survival by introducing Moyo Fetal Heart Rate (FHR) Monitor coupled with neonatal resuscitation simulation training.

Methods: The implementation was done at three district hospitals. We assessed health care workers' (HCW's) skills and perinatal death trends during implementation. Read More

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Systematic review and meta-analysis on the influence of thyroid dysfunction in early pregnancy on pregnancy outcomes under ultrasound guidance.

Ann Palliat Med 2022 Mar;11(3):1001-1016

Department of Ultrasound, Shijiazhuang Fourth Hospital, Shijiazhuang, China.

Background: Thyroid dysfunction during pregnancy has a certain impact on pregnancy outcomes and neonatal growth, but there is no systematic evaluation of the influence of thyroid dysfunction during early pregnancy under ultrasound guidance on pregnancy outcomes.

Methods: PubMed, Web of Science, Springer, and Science Direct databases were used to screen clinical studies on the effect of thyroid dysfunction during pregnancy on pregnancy outcomes from January 2010 to June 2021. Meta-analysis of data was conducted using RevMan 5. Read More

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Third Trimester Structural and Diffusion Brain Imaging after Single Intrauterine Fetal Death in Monochorionic Twins: MRI-Based Cohort Study.

AJNR Am J Neuroradiol 2022 04 24;43(4):620-626. Epub 2022 Mar 24.

From the Section of Neuroradiology (M.S., B.D., C.H., S.S.)

Background And Purpose: Single intrauterine fetal death increases the risk of antenatal brain lesions in the surviving twin. We evaluated the prevalence of structural brain lesions, biometry, and diffusivity on routine third trimester MR imaging performed following single intrauterine fetal death.

Materials And Methods: In a retrospective MR imaging-based cohort study, we compared 29 monochorionic twins complicated with single intrauterine fetal death (14 following laser ablation treatment for twin-to-twin transfusion syndrome, 8 following selective fetal reduction, and 7 spontaneous) with 2 control cohorts (49 singleton fetuses and 28 uncomplicated twin fetuses). Read More

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Late pregnancy ultrasound parameters identifying fetuses at risk of adverse perinatal outcomes: a protocol for a systematic review of systematic reviews.

BMJ Open 2022 03 23;12(3):e058293. Epub 2022 Mar 23.

National Perinatal Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, Oxfordshire, UK.

Introduction: Stillbirths and neonatal deaths are leading contributors to the global burden of disease and pregnancy ultrasound has the potential to help decrease this burden. In the absence of high-Grading of Recommendations Assessment, Development and Evaluation (GRADE) evidence on universal obstetric ultrasound screening at or close to term, many different screening strategies have been proposed. Systematic reviews have rapidly increased over the past decade owing to the diverse nature of ultrasound parameters and the wide range of possible adverse perinatal outcomes. Read More

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Awareness of fetal movements and care package to reduce fetal mortality (AFFIRM): a trial-based and model-based cost-effectiveness analysis from a stepped wedge, cluster-randomised trial.

BMC Pregnancy Childbirth 2022 Mar 22;22(1):235. Epub 2022 Mar 22.

Maternal and Fetal Health Research Centre, School of Medical Sciences, University of Manchester, Manchester, UK.

Background: The AFFIRM intervention aimed to reduce stillbirth and neonatal deaths by increasing awareness of reduced fetal movements (RFM) and implementing a care pathway when women present with RFM. Although there is uncertainty regarding the clinical effectiveness of the intervention, the aim of this analysis was to evaluate the cost-effectiveness.

Methods: A stepped-wedge, cluster-randomised trial was conducted in thirty-three hospitals in the United Kingdom (UK) and Ireland. Read More

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Impact of Congenital Heart Defects on the Developing Brain.

Pediatr Dev Pathol 2022 Mar 12:10935266211045365. Epub 2022 Mar 12.

Department of Pathology, Sainte-Justine Hospital, Montreal, Quebec, Canada.

Objectives: Congenital heart defects (CHD) are responsible for neurodevelopmental delays that were initially attributed to brain injury resulting from cardiac surgery. However, prenatal imaging have shown that brain anomalies are present at birth. The aim of this study was to assess brain injuries before birth in fetuses/neonates with congenital cardiopathies. Read More

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Facility-based stillbirth surveillance review and response: an initiative towards reducing stillbirths in a tertiary care hospital of India.

J Perinat Med 2022 Mar 2. Epub 2022 Mar 2.

Department of Pediatrics (Neonatology), Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Objectives: India has the highest number of stillbirths in the world in 2019, with an estimated stillbirth rate of 13.9 per 1,000 births. Towards better identification and documentation, a stillbirth surveillance pilot was initiated with the World Health Organization Southeast Asia collaboration in Northern India in 2014. Read More

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Extreme Heat and Pregnancy Outcomes: A Scoping Review of the Epidemiological Evidence.

Int J Environ Res Public Health 2022 02 19;19(4). Epub 2022 Feb 19.

Interdisciplinary School of Health Sciences, Faculty of Health Sciences, University of Ottawa, Ottawa, ON K1N 6N5, Canada.

Background: Extreme heat caused by climate change is a major public health concern, disproportionately affecting poor and racialized communities. Gestational heat exposure is a well-established teratogen in animal studies, with a growing body of literature suggesting human pregnancies are similarly at risk. Characterization of extreme heat as a pregnancy risk is problematic due to nonstandard definitions of heat waves, and variable study designs. Read More

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February 2022

Transabdominal amnioinfusion: An evaluation of its adverse events.

Eur J Obstet Gynecol Reprod Biol 2022 Apr 8;271:132-137. Epub 2022 Feb 8.

Department of Fetal-Maternal Medicine, Nagara Medical Center, 1300-7 Nagara, Gifu, Japan; Division of Obstetrics and Gynecology, Matsunami General Hospital, 185-1, Tashiro, Kasamatsu-cho, Hashima, Gifu, Japan.

Objective: Transabdominal amnioinfusion is beneficial in oligohydramnios, which has high fetal mortality and does not improve with observation alone. However, there are few reports on the maternal adverse events of transabdominal amnioinfusion. This study aimed to evaluate the adverse events of amniocentesis with transabdominal amnioinfusion. Read More

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Recognition and management of traumatic fetal injuries.

Injury 2022 Apr 5;53(4):1329-1344. Epub 2022 Feb 5.

Division of Pediatric Surgery, University of Columbia School of Medicine, Columbia, MO, USA.

Trauma during pregnancy is the leading non-obstetric cause of morbidity and mortality, and accounts for five per 1000 fetal deaths. Direct fetal injury due to trauma during pregnancy is rare, and limited information is available about how to optimize fetal outcomes after injury. Early recognition and appropriate management of direct fetal trauma may improve outcomes for the fetus. Read More

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Arabin pessary to prevent adverse perinatal outcomes in twin pregnancies with a short cervix: a multicenter randomized controlled trial (PESSARONE).

Am J Obstet Gynecol 2022 Feb 3. Epub 2022 Feb 3.

Department of Obstetrics and Gynecology, Paule de Viguier Hospital, Toulouse University Hospital, Toulouse, France; Centre for Epidemiology and Research in Population Health, UMR 1295, Study of Perinatal, Pediatric and Adolescent Health: Epidemiological Research and Evaluation Team, Toulouse III University, Toulouse, France. Electronic address:

Background: The number of twin pregnancies continues to increase worldwide as both the number of pregnancies obtained by medically assisted reproduction and age at first pregnancy keep rising. Preterm delivery is the major complication associated with twin pregnancies. The effectiveness of preventive treatments such as progesterone or cervical cerclage for women with a short cervix is doubtful in twin pregnancies. Read More

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February 2022

Utility of fertility procedures and prenatal tests to estimate gestational age for live-births and stillbirths in electronic health plan databases.

Pharmacoepidemiol Drug Saf 2022 05 22;31(5):534-545. Epub 2022 Feb 22.

Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts, USA.

Purpose: Current algorithms to evaluate gestational age (GA) during pregnancy rely on hospital coding at delivery and are not applicable to non-live births. We developed an algorithm using fertility procedures and fertility tests, without relying on delivery coding, to develop a novel GA algorithm in live-births and stillbirths.

Methods: Three pregnancy cohorts were identified from 16 health-plans in the Sentinel System: 1) hospital admissions for live-birth, 2) hospital admissions for stillbirth, and 3) medical chart-confirmed stillbirths. Read More

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Severity of Anemia During Pregnancy and Adverse Maternal and Fetal Outcomes.

JAMA Netw Open 2022 02 1;5(2):e2147046. Epub 2022 Feb 1.

Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.

Importance: Anemia is the most widespread nutritional deficiency among pregnant females in the world. Despite numerous studies on anemia, evidence is limited about the association of severity of anemia with maternal and fetal health.

Objective: To investigate the association between severity of anemia during pregnancy and risk of maternal and fetal adverse outcomes. Read More

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February 2022