2,259 results match your criteria Evaluation of Fetal Death


Evaluation of Retinal Pigment Epithelial Cell Cytotoxicity of Recombinant Tissue Plasminogen Activator Using Human-Induced Pluripotent Stem Cells.

J Ophthalmol 2019 19;2019:7189241. Epub 2019 Mar 19.

Department of Ophthalmology, Kawasaki Medical School, 577 Matsushima, Kurashiki, Okayama 701-0114, Japan.

Purpose: The evaluation of drug-induced cytotoxicity is of great importance for the clinical application of pharmaceutical products, and human-induced pluripotent stem cells (hiPSCs) have received considerable scrutiny as a cell source for in vitro cytotoxicity testing. The aim of this study is to validate the concept of cytotoxicity testing using hiPSC-derived retinal pigment epithelium (hiPSC-RPE) by comparing the responsiveness of human fetal RPE (hfRPE) and human RPE cell line (ARPE19) to recombinant tissue plasminogen activator (rtPA).

Methods: HfRPE, two types of hiPSC-RPE, and ARPE19 were cultured in media with or without rtPA. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2019/7189241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444245PMC

Diabetes in pregnancy in associations with perinatal and postneonatal mortality in First Nations and non-Indigenous populations in Quebec, Canada: population-based linked birth cohort study.

BMJ Open 2019 Apr 15;9(4):e025084. Epub 2019 Apr 15.

Obstetrics and Gynecology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, and Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada.

Objective: Both pregestational and gestational diabetes mellitus (PGDM, GDM) occur more frequently in First Nations (North American Indians) pregnant women than their non-Indigenous counterparts in Canada. We assessed whether the impacts of PGDM and GDM on perinatal and postneonatal mortality may differ in First Nations versus non-Indigenous populations.

Design: A population-based linked birth cohort study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjopen-2018-025084DOI Listing
April 2019
1 Read

In vitro evaluation of the effects of capsaicin on normal and cancerous cells of human cartilage.

Turk J Biol 2018 25;42(5):422-434. Epub 2018 Oct 25.

Department of Agricultural Biotechnology, Faculty of Agriculture, Kahramanmaraş Sütçü İmam University , Kahramanmaraş , Turkey.

Chondrosarcoma is a common form of bone cancer which effects the fibrous connective tissue around a joint. It most commonly develops in legs, arms, shoulder blades, rib cage, and pelvis. Capsaicin is an active bitter compound found in red pepper, the fruit of the species Capsicum annuum, and it has been shown to have a lethal effect on different types of cancer. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3906/biy-1804-83DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438123PMC
October 2018
1 Read

Consensus outcome rating for international neonatal resuscitation guidelines.

Arch Dis Child Fetal Neonatal Ed 2019 Mar 29. Epub 2019 Mar 29.

Pediatrics-Neonatal, University of Michigan Hospital, Ann Arbor, Michigan, USA.

The International Liaison Committee on Resuscitation uses the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) working group method to evaluate the quality of evidence and the strength of treatment recommendations. This method requires guideline developers to use a numerical rating of the importance of each specified outcome. There are currently no uniform reporting guidelines or outcome measures for neonatal resuscitation science. Read More

View Article

Download full-text PDF

Source
http://fn.bmj.com/lookup/doi/10.1136/archdischild-2019-31694
Publisher Site
http://dx.doi.org/10.1136/archdischild-2019-316942DOI Listing
March 2019
3 Reads
3.120 Impact Factor

Completeness and reliability of the National Mortality Information System for perinatal deaths in Brazil, 2011-2012: a descriptive study.

Epidemiol Serv Saude 2019 03 21;28(1):e2018093. Epub 2019 Mar 21.

Fundação Instituto Oswaldo Cruz, Escola Nacional de Saúde Pública, Rio de Janeiro, RJ, Brasil.

Objective: to analyze the completeness and reliability of data on perinatal deaths held on Brazil's Mortality Information System (SIM) in 2011-2012.

Methods: this was a study evaluating the quality of completeness of data on perinatal deaths reported on SIM compared to data from the 'Birth in Brazil' survey for the same period; to evaluate reliability, we used the Kappa coefficient, the intraclass correlation coefficient (ICC) and the Bland-Altman plot method.

Results: completeness was greater than 80%, and agreement was 0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5123/S1679-49742019000100007DOI Listing
March 2019
1 Read

Checking the pregnancy checkbox: Evaluation of a four-state quality assurance pilot.

Birth 2019 Mar 14. Epub 2019 Mar 14.

Division of Reproductive Health, Centers for Disease Control and Prevention, Atlanta, Georgia.

Background: The 2003 revision of the standard United States death certificate included a set of "pregnancy checkboxes" to ascertain whether a woman was pregnant at the time of her death or within the preceding year. Studies validating the pregnancy checkbox have indicated a potentially high number of errors, resulting in inflated maternal mortality rates. In response to concerns about pregnancy checkbox data quality, four state health departments implemented a quality assurance pilot project examining the accuracy of the pregnancy checkbox for 2016 deaths. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/birt.12425DOI Listing

Evaluation of age of death in Niemann-Pick disease, type C: Utility of disease support group websites to understand natural history.

Mol Genet Metab 2019 Feb 15. Epub 2019 Feb 15.

Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, DHHS, Bethesda, MD, USA. Electronic address:

Niemann-Pick disease, type C (NPC) is a neurodegenerative lysosomal storage disease affecting the visceral organs and the central nervous system. The age of initial presentation varies from fetal to adult onset, although childhood onset is most common. The life expectancy for the full spectrum of NPC patients is not well defined, and it is unknown if current supportive care impacts the natural history. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ymgme.2019.02.004DOI Listing
February 2019
4 Reads

The DESiGN trial (DEtection of Small for Gestational age Neonate), evaluating the effect of the Growth Assessment Protocol (GAP): study protocol for a randomised controlled trial.

Trials 2019 Mar 4;20(1):154. Epub 2019 Mar 4.

Department of Women and Children's Health, School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, Women's Health Academic Centre KHP, 10th Floor North Wing, St. Thomas' Hospital, Westminster Bridge Road, London, SE1 7EH, UK.

Background: Stillbirth rates in the United Kingdom (UK) are amongst the highest of all developed nations. The association between small-for-gestational-age (SGA) foetuses and stillbirth is well established, and observational studies suggest that improved antenatal detection of SGA babies may halve the stillbirth rate. The Growth Assessment Protocol (GAP) describes a complex intervention that includes risk assessment for SGA and screening using customised fundal-height growth charts. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13063-019-3242-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398257PMC
March 2019
4 Reads

Diagnosis and clinical delineation of mosaic tetrasomy 5p.

Eur J Med Genet 2019 Feb 21. Epub 2019 Feb 21.

833 Chestnut Street, Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, Thomas Jefferson University Hospital, Philadelphia, PA, U19107, USA. Electronic address:

Objective: Our objective was to review the phenotypic and genetic characteristics of tetrasomy 5p from the fetal period until adulthood including prenatal diagnostic evaluations.

Background: Tetrasomy 5p is a rare chromosomal abnormality. Of the 14 reports, most document mosaic tetrasomy 5p resulting from a supernumerary marker chromosome or isochromosome. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejmg.2019.02.006DOI Listing
February 2019
1 Read

Comparison of two identification and susceptibility test kits for Ureaplasma spp and Mycoplasma hominis in amniotic fluid of patients at high risk for intra-amniotic infection.

J Matern Fetal Neonatal Med 2019 Feb 20:1-9. Epub 2019 Feb 20.

e Obstetrical Intensive Care Unit, Maternal-Infant Department , Fundación Valle del Lili , Cali , Colombia.

Objective: Ureaplasma urealyticum and Mycoplasma hominis are the most common microorganisms found in the amniotic fluid of patients at risk for preterm delivery. However, culture techniques for genital mycoplasms require special conditions, are barely considered as part of the evaluation of suspected intra-amniotic infection (IAI) and the results are available within 2 and 7 days. The objectives of this study are to validate the use of two commercially available kits (Mycoplasma IES y MYCOFAST RevolutioN) for the identification of Ureaplasma spp. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/14767058.2019.1572742DOI Listing
February 2019
1 Read

Using fetal scalp stimulation with Doppler ultrasonography to enhance intermittent auscultation in low-resource settings: a diagnostic trial from Tanzania.

BMC Pregnancy Childbirth 2019 Feb 13;19(1):71. Epub 2019 Feb 13.

Hubert-Yeargan Center for Global Health, Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC, USA.

Background: Hypoxia during labor contributes to 2.2 million intrapartum and early neonatal deaths each year. An additional 0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12884-019-2212-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374908PMC
February 2019
3 Reads

Deferred and referred deliveries contribute to stillbirths in the Indian state of Bihar: results from a population-based survey of all births.

BMC Med 2019 Feb 7;17(1):28. Epub 2019 Feb 7.

Public Health Foundation of India, Sector 44, Institutional Area, Gurugram, National Capital Region, India.

Background: The India Newborn Action Plan (INAP) aims for < 10 stillbirths per 1000 births by 2030. A population-based understanding of risk factors for stillbirths compared with live births that could assist with reduction of stillbirths is not readily available for the Indian population.

Methods: Detailed interviews were conducted in a representative sample of all births between January and December 2016 from 182,486 households (96. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12916-019-1265-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366028PMC
February 2019
3 Reads

Trauma in Pregnancy: A Comprehensive Approach to the Mother and Fetus.

Am J Obstet Gynecol 2019 Jan 24. Epub 2019 Jan 24.

Department of Surgery, University of Arizona College of Medicine-Phoenix at Banner University Medical Center, Phoenix, AZ.

Trauma is a significant contributor to maternal and fetal morbidity and death in the United States. The nature of the evaluation of the pregnant trauma patient is intense and multidisciplinary. Although it invites unique opportunities for collaboration with our surgical colleagues, it also increases the risk of misunderstanding and conflict. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ajog.2019.01.209DOI Listing
January 2019
1 Read

Association of Prenatal Ultrasonographic Findings With Adverse Neonatal Outcomes Among Pregnant Women With Zika Virus Infection in Brazil.

JAMA Netw Open 2018 Dec 7;1(8):e186529. Epub 2018 Dec 7.

Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco.

Importance: Congenital Zika virus infection causes a spectrum of adverse birth outcomes, including severe birth defects of the central nervous system. The association of prenatal ultrasonographic findings with adverse neonatal outcomes, beyond structural anomalies such as microcephaly, has not been described to date.

Objective: To determine whether prenatal ultrasonographic examination results are associated with abnormal neonatal outcomes in Zika virus-affected pregnancies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/jamanetworkopen.2018.6529DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324324PMC
December 2018
5 Reads

Parameters for estimating the time of death at perinatal autopsy of stillborn fetuses: a systematic review.

Int J Legal Med 2019 Mar 8;133(2):483-489. Epub 2019 Jan 8.

Pathology Unit, Department of Public Health, School of Medicine, University of Naples Federico II, Naples, Italy.

Background: Stillbirth is defined by the WHO as birth of a fetus with no vital signs, at or over 28 weeks of pregnancy age. The estimation of time of death in stillbirth appears crucial in forensic pathology. However, there are no validated methods for this purpose. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00414-019-01999-1DOI Listing
March 2019
2 Reads
2.714 Impact Factor

Magnetic resonance imaging for prenatal estimation of birthweight in pregnancy: review of available data, techniques, and future perspectives.

Am J Obstet Gynecol 2018 Dec 22. Epub 2018 Dec 22.

Department of Obstetrics and Gynecology, University Hospital Brugmann, Université Libre de Bruxelles, Brussels, Belgium. Electronic address:

Fetuses at the extremes of growth abnormalities carry a risk of perinatal morbidity and death. Their identification traditionally is done by 2-dimensional ultrasound imaging, the performance of which is not always optimal. Magnetic resonance imaging superbly depicts fetal anatomy and anomalies and has contributed largely to the evaluation of high-risk pregnancies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ajog.2018.12.031DOI Listing
December 2018
13 Reads

An autopsy case of epignathus (immature teratoma of the soft palate) with intracranial extension but without brain invasion: case report and literature review.

Diagn Pathol 2018 Dec 22;13(1):99. Epub 2018 Dec 22.

Department of Pathology, Field of Oncology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima, 890-8544, Japan.

Background: Epignathus is a rare congenital orofacial teratoma infrequently associated with intracranial extension. Intracranial extension of an epignathus indicates a poor prognosis; however, only a small number of such cases have been reported. While there have been some studies reporting cases of epignathus expanding directly into the cranium, others have reported no communication between an epignathus and an intracranial tumor. Read More

View Article

Download full-text PDF

Source
https://diagnosticpathology.biomedcentral.com/articles/10.11
Publisher Site
http://dx.doi.org/10.1186/s13000-018-0776-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303979PMC
December 2018
15 Reads

Care prior to and during subsequent pregnancies following stillbirth for improving outcomes.

Cochrane Database Syst Rev 2018 12 17;12:CD012203. Epub 2018 Dec 17.

NHMRC Centre of Research Excellence in Stillbirth, Mater Research Institute - The University of Queensland (MRI-UQ), Level 3 Aubigny Place, Mater Health Services, Brisbane, Queensland, Australia, 4101.

Background: Stillbirth affects at least 2.6 million families worldwide every year and has enduring consequences for parents and health services. Parents entering a subsequent pregnancy following stillbirth face a risk of stillbirth recurrence, alongside increased risks of other adverse pregnancy outcomes and psychosocial challenges. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/14651858.CD012203.pub2DOI Listing
December 2018
23 Reads

Intrauterine fetal MR versus postmortem MR imaging after therapeutic termination of pregnancy: evaluation of the concordance in the detection of brain abnormalities at early gestational stage.

Eur Radiol 2018 Dec 12. Epub 2018 Dec 12.

Pediatric Radiology and Neuroradiology Department, Children's Hospital V. Buzzi - ASST Fatebenefratelli-Sacco, Via Castelvetro 32, 20154, Milan, Italy.

Background And Purpose: Fetal postmortem MR Imaging (pmMRI) has been recently used as an adjuvant tool to conventional brain autopsy after termination of pregnancy (TOP). Our purpose was to compare the diagnostic performance of intrauterine MRI (iuMRI) and pmMRI in the detection of brain anomalies in fetuses at early gestational age (GA).

Material And Methods: We retrospectively collected 53 fetuses who had undergone iuMRI and pmMRI for suspected brain anomalies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00330-018-5878-0DOI Listing
December 2018

Cost-effectiveness of continuity of midwifery care for women with complex pregnancy: a structured review of the literature.

Health Econ Rev 2018 Dec 5;8(1):32. Epub 2018 Dec 5.

Menzies Health Institute Queensland, Griffith University, Gold Coast, Queensland, 4222, Australia.

Background: Critical evaluation of the cost-effectiveness and clinical effectiveness of continuity of midwifery care models for women experiencing complex pregnancy is an important consideration in the review and reform of maternity services. Most studies either focus on women who experience healthy pregnancy or mixed risk samples. These results may not be generalised across the childbearing continuum to women with risk factors. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13561-018-0217-3DOI Listing
December 2018
3 Reads

Risk prediction models for maternal mortality: A systematic review and meta-analysis.

PLoS One 2018 4;13(12):e0208563. Epub 2018 Dec 4.

Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada.

Purpose: Pregnancy-related critical illness leads to death for 3-14% of affected women. Although identifying patients at risk could facilitate preventive strategies, guide therapy, and help in clinical research, no prior systematic review of this literature exploring the validity of risk prediction models for maternal mortality exists. Therefore, we have systematically reviewed and meta-analyzed risk prediction models for maternal mortality. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0208563PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279047PMC
December 2018
25 Reads

Ursodeoxycholic acid versus placebo in the treatment of women with intrahepatic cholestasis of pregnancy (ICP) to improve perinatal outcomes: protocol for a randomised controlled trial (PITCHES).

Trials 2018 Nov 27;19(1):657. Epub 2018 Nov 27.

University of Nottingham, Nottingham, UK.

Background: Intrahepatic cholestasis of pregnancy (ICP) is the most common liver disorder specific to pregnancy and presents with maternal pruritus, raised concentrations of serum bile acids and abnormal liver function tests. ICP is associated with increased rates of spontaneous and iatrogenic preterm labour, fetal hypoxia, meconium-stained amniotic fluid and intrauterine death. Some clinicians treat ICP with ursodeoxycholic acid (UDCA) to improve maternal pruritus and biochemical abnormalities. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13063-018-3018-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260710PMC
November 2018
14 Reads

Outcomes in prevention and management of miscarriage trials: a systematic review.

BJOG 2019 Jan;126(2):176-189

Institute of Metabolism and Systems Research, College of Medical & Dental Sciences, University of Birmingham, Birmingham, UK.

Background: There is a substantial body of research evaluating ways to prevent and manage miscarriage, but all studies do not report on the same outcomes.

Objective: To review systematically, outcomes reported in existing miscarriage trials.

Search Strategy: MEDLINE, Embase, CINAHL, and Cochrane were searched from inception until January 2017. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/1471-0528.15528DOI Listing
January 2019
17 Reads

[Antenatal management in case of preterm premature rupture of membranes before fetal viability: CNGOF Preterm Premature Rupture of Membranes Guidelines].

Authors:
E Azria

Gynecol Obstet Fertil Senol 2018 12 6;46(12):1076-1088. Epub 2018 Nov 6.

Maternité Notre Dame de Bon Secours, groupe hospitalier Paris Saint-Joseph, DHU risques et grossesse, 185, rue Raymond-Losserand, 75014 Paris, France; Inserm UMR 1153, équipe de recherche en épidémiologie obstétricale, périnatale et pédiatrique (EPOPé), centre de recherche épidémiologie et statistique Sorbonne Paris Cité, université Paris Descartes, 75014 Paris, France. Electronic address:

Objectives: To evaluate the maternal, perinatal and long-term prognosis in the event of previable premature rupture of the membranes (PROM) and to specify the interventions likely to reduce the risks and improve the prognosis.

Methods: The PubMed database, the Cochrane Library and the recommendations from the French and foreign obstetrical societies or colleges have been consulted.

Results: Previable PROM is a rare event whose frequency varies from 0. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S24687189183027
Publisher Site
http://dx.doi.org/10.1016/j.gofs.2018.10.023DOI Listing
December 2018
16 Reads

The Placenta in Neonatal Encephalopathy: A Case-Control Study.

J Pediatr 2018 11 29;202:77-85.e3. Epub 2018 Jun 29.

Department of Pediatrics and Neurology and Neurosurgery, McGill University, Montreal, Québec, Canada.

Objective: We assessed whether specific histologic placental lesions were associated with risk for neonatal encephalopathy, a strong predictor of death or cerebral palsy.

Study Design: Case-control study of singletons with gestational ages ≥35 weeks. Data were abstracted from a prospectively collected database of consecutive births at a hospital in which placental samples from specified sites are collected and stored for all inborn infants. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00223476183077
Publisher Site
http://dx.doi.org/10.1016/j.jpeds.2018.06.005DOI Listing
November 2018
10 Reads

The incidence of unexpected critical complications in monochorionic diamniotic twin pregnancies according to the interval period between ultrasonographic evaluations.

J Obstet Gynaecol Res 2019 Feb 10;45(2):318-324. Epub 2018 Oct 10.

Department of Maternal Fetal Medicine, Osaka Women's and Children's Hospital, Osaka, Japan.

Aim: This study aimed to evaluate the incidence of unexpected critical complications (UCC) in monochorionic diamniotic (MCDA) twin pregnancies according to ultrasonographic scan interval.

Methods: This retrospective single-center cohort study, conducted between January 2005 and April 2015, investigated the incidence of UCC in patients with MCDA twin pregnancies undergoing weekly ultrasound (Group A) and those undergoing biweekly ultrasound (Group B). We also examined the incidence of predictable critical complications according to ultrasound interval. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/jog.13827
Publisher Site
http://dx.doi.org/10.1111/jog.13827DOI Listing
February 2019
6 Reads

Persistent inaccuracies in completion of medical certificates of stillbirth: A cross-sectional study.

Paediatr Perinat Epidemiol 2018 09 9;32(5):474-481. Epub 2018 Oct 9.

Faculty of Biology Medicine and Health, Maternal and Fetal Health Research Centre, University of Manchester, Manchester, UK.

Background: The UK Medical Certificate of Stillbirth (MCS) records information relevant to the cause of stillbirth of infants ≥24 weeks' gestation. A cross-sectional audit demonstrated widespread inaccuracies in MCS completion in 2009 in North West England. A repeat study was conducted to assess whether practice had improved following introduction of a regional care pathway. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/ppe.12501
Publisher Site
http://dx.doi.org/10.1111/ppe.12501DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221058PMC
September 2018
4 Reads

No. 367-2019 Canadian Guideline for Physical Activity throughout Pregnancy.

J Obstet Gynaecol Can 2018 Nov 5;40(11):1528-1537. Epub 2018 Oct 5.

Victoria, BC.

Objective: The objective is to provide guidance for pregnant women, and obstetric care and exercise professionals, on prenatal physical activity.

Outcomes: The outcomes evaluated were maternal, fetal, or neonatal morbidity or fetal mortality during and following pregnancy.

Evidence: Literature was retrieved through searches of Medline, EMBASE, PsycINFO, Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, Scopus and Web of Science Core Collection, CINAHL Plus with Full-text, Child Development & Adolescent Studies, ERIC, Sport Discus, ClinicalTrials. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S17012163183056
Publisher Site
http://dx.doi.org/10.1016/j.jogc.2018.07.001DOI Listing
November 2018
28 Reads

Environmental Contaminants and Congenital Heart Defects: A Re-Evaluation of the Evidence.

Authors:
Rachel Nicoll

Int J Environ Res Public Health 2018 09 25;15(10). Epub 2018 Sep 25.

Department of Public Health and Clinical Medicine, Umeå University, SE 901-87 Umeå, Sweden.

Congenital heart defects (CHDs) are a common birth defect of largely unknown etiology, with high fetal and neonatal mortality. A review of CHDs and environmental contaminant exposure found that meta-analyses showed only modest associations for smoking, vehicle exhaust components, disinfectant by-products and proximity to incinerators, with stronger results from the newer, larger and better quality studies masked by the typical absence of effect in older studies. Recent studies of exposure to agricultural pesticides, solvents, metals and landfill sites also showed associations. Read More

View Article

Download full-text PDF

Source
http://www.mdpi.com/1660-4601/15/10/2096
Publisher Site
http://dx.doi.org/10.3390/ijerph15102096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6210579PMC
September 2018
16 Reads

Perinatal death beyond 41 weeks pregnancy: an evaluation of causes and substandard care factors as identified in perinatal audit in the Netherlands.

BMC Pregnancy Childbirth 2018 Sep 20;18(1):380. Epub 2018 Sep 20.

Department of Obstetrics and Gynaecology, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6523, GA, Nijmegen, the Netherlands.

Background: Late- and postterm pregnancy are associated with adverse perinatal outcomes, like perinatal death. We evaluated causes of death and substandard care factors (SSFs) in term and postterm perinatal death.

Methods: We used data from the Perinatal Audit Registry of the Netherlands (PARS). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12884-018-1973-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149052PMC
September 2018
14 Reads

Ethical Issues in Intrauterine Myelomeningocele Surgery.

New Bioeth 2018 Nov 20;24(3):249-257. Epub 2018 Sep 20.

c Medical Student, Facultad de Ciencias Biomédicas , Universidad Austral , Buenos Aires , Argentina.

Intrauterine surgery shows that the prognosis of neonates with myelomeningocele (MMC) has improved, both in survival and in quality of life. In order to study the current efficacy of intrauterine surgery for MMC and to make an ethical analysis of its proportionality, we conducted a PubMed search using the keywords "myelomeningocele", "intrauterine surgery", "MOMS", and "trial". Thirty-eight articles were found. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/20502877.2018.1521499DOI Listing
November 2018
3 Reads

Factors associated with first thrombosis in patients presenting with obstetric antiphospholipid syndrome (APS) in the APS Alliance for Clinical Trials and International Networking Clinical Database and Repository: a retrospective study.

BJOG 2019 Apr 24;126(5):656-661. Epub 2018 Oct 24.

Department of Rheumatology, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil.

Objective: To evaluate the subsequent rate of thrombosis among women with obstetric antiphospholipid syndrome (Ob-APS) in a multicentre database of antiphospholipid antibody (aPL)-positive patients, and the clinical utility of the adjusted Global Antiphospholipid Syndrome Score (aGAPSS), a validated tool to assess the likelihood of developing new thrombosis, in this group of patients.

Design: Retrospective study.

Setting: The Antiphospholipid Syndrome Alliance for Clinical Trials and International Networking Clinical Database and Repository. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/1471-0528.15469DOI Listing
April 2019
2 Reads

Evolving Decisions: Perspectives of Active and Athletic Individuals with Inherited Heart Disease Who Exercise Against Recommendations.

J Genet Couns 2018 Sep 15. Epub 2018 Sep 15.

Stanford Center for Inherited Cardiovascular Disease, Stanford Healthcare, Stanford, CA, USA.

Individuals with hypertrophic cardiomyopathy (HCM) and long QT syndrome (LQTS) are advised to avoid certain forms of exercise to reduce their risk of sudden death. Cardiovascular genetic counselors facilitate both adaptation to, and decision-making about, these exercise recommendations. This study describes decision-making and experiences of active adults who exercise above physicians' recommendations. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10897-018-0297-6DOI Listing
September 2018
8 Reads

New terminology for adverse events of fetal therapy: Re-evaluation of the thoraco-amniotic shunting in a Japanese study.

J Obstet Gynaecol Res 2019 Feb 6;45(2):251-257. Epub 2018 Sep 6.

Department of Obstetrics and Gynecology, Toho University Omori Medical Center, Tokyo, Japan.

Aim: Since fetal therapy has been newly developed, objective evaluation of adverse events (AE), all harmful events that are not always related to the procedures, has not yet been adequately reported. We established new terminology and tried to re-evaluate it based on the Japanese prospective thoraco-amniotic shunting (TAS) study.

Methods: From the literature, all complications that occurred with all fetal therapies were identified as a basis for developing the terminology. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jog.13804DOI Listing
February 2019
8 Reads

Admission cardiotocography versus intermittent auscultation of the fetal heart in low-risk pregnancy during evaluation for possible labour admission - a multicentre randomised trial: the ADCAR trial.

BJOG 2019 Jan 19;126(1):114-121. Epub 2018 Sep 19.

School of Nursing and Midwifery, National University of Ireland, Galway, Ireland.

Objective: To assess the effect of admission cardiotocography (ACTG) versus intermittent auscultation (IA) of the fetal heart (FH) in low-risk pregnancy during assessment for possible labour on caesarean section rates.

Design: A parallel multicentre randomised trial.

Setting: Three maternity units in the Republic of Ireland. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/1471-0528.15448
Publisher Site
http://dx.doi.org/10.1111/1471-0528.15448DOI Listing
January 2019
27 Reads

Urgent Cesarean Delivery Following a Spontaneous Coronary Artery Dissection.

Am J Case Rep 2018 Aug 15;19:956-961. Epub 2018 Aug 15.

Clinic of Cardiovascular Disease, San Martino Policlinic Hospital, University of Genova, Genova, Italy.

BACKGROUND Spontaneous coronary artery dissection is the most common etiology of pregnancy-associated myocardial infarction. It is characterized by high rates of maternal morbidity and mortality and may cause fetal complications and death as well. CASE REPORT A 44-year-old female (G2P1) suffered from pregnancy-related spontaneous coronary artery dissection with dissection of distal left anterior descending coronary artery. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12659/AJCR.909821DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6106692PMC
August 2018
4 Reads

Radiographic evaluation of the pregnant trauma patient: What are We willing to miss?

Eur J Obstet Gynecol Reprod Biol 2018 Sep 28;228:325-328. Epub 2018 Jun 28.

Ohio Health Grant Medical Center, Columbus, Ohio, United States.

Objective: Trauma is the leading cause of non-obstetrical causes of death in pregnant patients. The use of radiographic imaging for evaluation in the trauma bay is a controversial topic. However, in some cases the benefits of using radiographic imaging to ensure maternal survival outweigh the risks of radiation exposure to the fetus. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejogrb.2018.06.039DOI Listing
September 2018
3 Reads

Decreasing use of autopsy for stillbirths and infant deaths: missed opportunity.

J Perinatol 2018 Oct 3;38(10):1414-1419. Epub 2018 Aug 3.

Department of Pediatrics, University of Toronto, Mount Sinai Hospital, 600 University Avenue, Toronto, M5G 1X5, Canada.

Objective: We assessed whether the tendency towards decreasing use of fetal and infant autopsy was associated with a greater proportion of deaths in which the cause is never found.

Study Design: We computed autopsy rates over time for 13,466 stillbirths and 16,880 infant deaths in Quebec, Canada, 1981-2015. We assessed the proportion of deaths with an undetermined cause and determined the relationship with non-autopsy over time. Read More

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41372-018-0191-y
Publisher Site
http://dx.doi.org/10.1038/s41372-018-0191-yDOI Listing
October 2018
16 Reads

Environmental and individual exposure and the risk of congenital anomalies: a review of recent epidemiological evidence.

Epidemiol Prev 2018 May-Aug;42(3-4 Suppl 1):1-34

Unit of Environmental Epidemiology and Disease Registries, Institute of Clinical Physiology, National Research Council, Pisa (Italy).

Introduction: Congenital anomalies (CAs) represent one of the main cause of foetal death, infant mortality and morbidity, and long-term disability. CAs have been object of systematic registration activity for a long-time in many geographical areas in Europe and worldwide. CAs are often associated with disabilities of different types and severity, including the developed Countries worldwide. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.19191/EP18.3-4.S1.P001.057DOI Listing
January 2019
6 Reads

Association of participation in a supplemental nutrition program with stillbirth by race, ethnicity, and maternal characteristics.

BMC Pregnancy Childbirth 2018 Jul 24;18(1):306. Epub 2018 Jul 24.

Department of Epidemiology, Rollins School of Public Health, Emory University, 1518 Clifton Road, Atlanta, GA, 30322, USA.

Background: Participation in the Special Supplemental Nutrition Program for Women, Infants and Children (WIC) has been associated with lower risk of stillbirth. We hypothesized that such an association would differ by race/ethnicity because of factors associated with WIC participation that confound the association.

Methods: We conducted a secondary analysis of the Stillbirth Collaborative Research Network's population-based case-control study of stillbirths and live-born controls, enrolled at delivery between March 2006 and September 2008. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12884-018-1920-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056947PMC
July 2018
6 Reads

Coupling a reproductive function model to a productive function model to simulate lifetime performance in dairy cows.

Animal 2019 Mar 24;13(3):570-579. Epub 2018 Jul 24.

2Université Clermont Auvergne,UMR 1213 Herbivores,VetAgro Sup,INRA,63122 Saint-Genès-Champanelle,France.

Reproductive success is a key component of lifetime performance in dairy cows but is difficult to predict due to interactions with productive function. Accordingly, this study introduces a dynamic model to simulate the productive and reproductive performance of a cow during her lifetime. The cow model consists of an existing productive function model (GARUNS) which is coupled to a new reproductive function model (RFM). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1017/S1751731118001830DOI Listing
March 2019
1 Read

Implementing a Protocol to Optimize Detection of Chromosome Abnormalities in Cases of Miscarriage or Stillbirth at a Midwestern Teaching Hospital.

Perm J 2018 ;22:17-204

Clinical Assistant Professor in Obstetrics and Gynecology at the University of Kansas School of Medicine in Wichita.

Context: Results from chromosome testing after spontaneous abortion (SAB) or intrauterine fetal demise (IUFD) are useful in patient counseling; however, results can be inconclusive when cell cultures for chromosomes are unable to grow from products of conception. Chromosomal microarray analysis (CMA) can analyze DNA from nonviable fetal tissue.

Objective: To examine whether establishing a genetic testing protocol for karyotype and CMA on SAB and IUFD tissues increases diagnostic yield. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7812/TPP/17-204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047853PMC
December 2018
17 Reads

Cost-effectiveness of diagnostic tests for threatened preterm labor in singleton pregnancy in France.

Cost Eff Resour Alloc 2018 14;16:21. Epub 2018 Jun 14.

Clinical Epidemiology Unit, Inserm, CIC 1432, Dijon, France.

Background: Previous studies have showed that the early diagnosis of threatened preterm labor decreases neonatal morbidity and mortality, avoids maternal morbidity induced by antepartum bed rest and unnecessary treatment, and reduces costs. Although there are many diagnostic tests, none is clearly recommended by international guidelines. The aim of our study was to compare seven diagnostic methods in terms of effectiveness and cost using a decision analysis model in singleton pregnancy presenting threatened preterm labor, between 24 and 34 weeks of gestation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12962-018-0106-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003030PMC
June 2018
9 Reads

Does progesterone prophylaxis to prevent preterm labour improve outcome? A randomised double-blind placebo-controlled trial (OPPTIMUM).

Health Technol Assess 2018 06;22(35):1-304

Centre for Healthcare Randomised Trials, Health Services Research Unit, University of Aberdeen, Aberdeen, UK.

Background: Progesterone prophylaxis is widely used to prevent preterm birth but is not licensed and there is little information on long-term outcome.

Objective: To determine the effect of progesterone prophylaxis in women at high risk of preterm birth on obstetric, neonatal and childhood outcomes.

Design: Double-blind, randomised placebo-controlled trial. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3310/hta22350DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036405PMC
June 2018
7 Reads

A shortened study design for embryo-fetal development studies in the minipig.

Reprod Toxicol 2018 09 22;80:35-43. Epub 2018 Jun 22.

Ellegaard Göttingen Minipigs, Dalmose, Denmark.

The minipig is accepted from scientific and regulatory perspectives for the safety evaluation of drug candidates on embryo-fetal development. The relative size and the duration of gestation (112-115 days) in the minipig is, however, considered a drawback compared with routine smaller species. We evaluated if study duration and cost could be optimized without impacting scientific validity by performing all terminal procedures around mid-gestation (60 days). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.reprotox.2018.06.009DOI Listing
September 2018
5 Reads

Stillbirth and perinatal care: Are professionals trained to address parents' needs?

Midwifery 2018 Sep 7;64:53-59. Epub 2018 Jun 7.

CiaoLapo Onlus, Charity for Stillbirth and Perinatal Grief Support, Prato, Italy; International Stillbirth Alliance, Bristol, UK; Department of Neurosciences, Psychology, Drug Research and Child Health (NeuroFarBa), University of Florence, Viale Pieraccini 6, 50139 Firenze, Italy. Electronic address:

Objective: To assess current practices of health care providers (HCPs) caring for women experiencing a stillbirth and to explore their needs for training to better support bereaved families.

Design: Nationwide cross-sectional survey. The main outcome measures were the evaluation of HCPs cognition, emotions and behaviours with regard to the care of women with a stillbirth care, as well as their compliance with international guidelines. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.midw.2018.05.008DOI Listing
September 2018
7 Reads

The Possibility of Postmortem Magnetic Resonance Imaging for the Diagnostics of Lung Hypoplasia.

Bull Exp Biol Med 2018 Jun 20;165(2):288-291. Epub 2018 Jun 20.

V. I. Kulakov National Medical Research Centre of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia.

We explored the possibility of using postmortem MRI for the diagnostics of lung hypoplasia associated with innate diaphragmatic hernia in neonates. The main experimental group consisted of 17 newborns with innate diaphragmatic hernia including 10 non-operated newborns and 7 newborns died after surgery for innate diaphragmatic hernia. It was demonstrated that postmortem MRI allows objective quantitative assessment of the absolute and relative dimensions of the lungs in the thoracic cavity and thereby reveals their hypoplasia, which contributes to the determination of tanatogenesis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10517-018-4150-6DOI Listing
June 2018
7 Reads

Intraamniotic Zika virus inoculation of pregnant rhesus macaques produces fetal neurologic disease.

Nat Commun 2018 06 20;9(1):2414. Epub 2018 Jun 20.

California National Primate Research Center, University of California, 1 Shields Avenue, Davis, CA, 95616, USA.

Zika virus (ZIKV) infection of pregnant women can cause fetal microcephaly and other neurologic defects. We describe the development of a non-human primate model to better understand fetal pathogenesis. To reliably induce fetal infection at defined times, four pregnant rhesus macaques are inoculated intravenously and intraamniotically with ZIKV at gestational day (GD) 41, 50, 64, or 90, corresponding to first and second trimester of gestation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41467-018-04777-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010452PMC
June 2018
37 Reads
10.742 Impact Factor

Smoking ban and health at birth: Evidence from Hungary.

Econ Hum Biol 2018 09 13;30:37-47. Epub 2018 Jun 13.

Institute for Sociology, Centre for Social Sciences, Hungarian Academy of Sciences, Tóth Kálmán u. 4., 1097 Budapest, Hungary; MTA-ELTE Peripato Comparative Social Dynamics Research Group, Pázmány Péter sétány 1/A, 1117 Budapest, Hungary. Electronic address:

In 2012, smoking restrictions were extended to hospitality venues in Hungary. Women working in bars and restaurants were primarily affected by the intervention. In this research, we analyze the effect of this smoking ban on the outcomes of their pregnancies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ehb.2018.05.003DOI Listing
September 2018