1,564,293 results match your criteria Evaluation & the Health Professions [Journal]


Comparative Study of Frozen and Paraffin-Embedded Sections: Evaluation of Inflammatory Dermatoses.

Isr Med Assoc J 2019 Feb;21(2):82-84

Department of Dermatology, Sourasky Tel Aviv Medical Center, Tel Aviv, Israel.

Background: Frozen section (FS) is often performed when histopathological evaluations are urgently required for implementation of therapeutic measures. In dermatology, this method is most commonly used to evaluate excision margins of tumors. FS are also routinely employed to differentiate toxic epidermal necrolysis from staphylococcal scalded skin syndrome. Read More

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February 2019

Evaluating the health risk of metals (Zn, Cr, Cd, Ni, Pb) in staple foods from Lagos and Ogun States, Southwestern Nigeria.

Environ Monit Assess 2019 Feb 16;191(3):167. Epub 2019 Feb 16.

Department of Pure and Applied Zoology, Federal University of Agriculture, Abeokuta, Ogun State, PMB 2240, Nigeria.

The study evaluated the health risk of metals in commonly consumed staple foods from Lagos and Ogun states, southwestern Nigeria. One hundred and thirty-three food samples were collected and analyzed for Zn, Cr, Cd, Ni, and Pb using atomic absorption spectrophotometric method. Data collected were analyzed for simple descriptive and inferential statistics using SPSS for Windows. Read More

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http://dx.doi.org/10.1007/s10661-019-7307-5DOI Listing
February 2019

Novel use of tranexamic acid to reduce the need for Nasal Packing in Epistaxis (NoPac) randomised controlled trial: research protocol.

BMJ Open 2019 Feb 15;9(2):e026882. Epub 2019 Feb 15.

Research Design Service South West, Bristol, UK.

Introduction: Patients presenting to emergency departments (EDs) with epistaxis uncontrolled by subsequent simple first aid measures or application of topical vasoconstrictors will typically undergo anterior nasal packing. Packing is effective, but can be extremely painful and unpleasant and patients usually need hospital admission. Tranexamic acid (TXA) is a cheap, safe, readily available antifibrinolytic agent known to be beneficial in a variety of clinical settings where uncontrolled bleeding may be a problem. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-026882DOI Listing
February 2019

Defining compassion in the digital health age: protocol for a scoping review.

BMJ Open 2019 Feb 15;9(2):e026338. Epub 2019 Feb 15.

Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.

Introduction: The notion of compassion and compassionate care is playing an increasingly important role in health professional education and in the delivery of high-quality healthcare. Digital contexts, however, are not considered in the conceptualisation of compassionate care, nor is there guidance on how compassionate care is to be exercised while using digital health technologies. The widespread diffusion of digital health technologies provides new contexts for compassionate care, with both opportunities for new forms and instantiations of compassion as well as new challenges. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-026338DOI Listing
February 2019

Lung Cancer App (LuCApp) study protocol: a randomised controlled trial to evaluate a mobile supportive care app for patients with metastatic lung cancer.

BMJ Open 2019 Feb 15;9(2):e025483. Epub 2019 Feb 15.

Centre for Research in Health and Social Care Management (CERGAS), SDA Bocconi, Milano, Italy.

Introduction: Mobile health technologies may enhance patient empowerment and data integration along the whole care continuum. However, these interventions pose relatively new regulatory, organisational and technological challenges that limit appropriate evaluation. Lung Cancer App (LuCApp) is a mobile application developed by researchers and clinicians to promote real-time monitoring and management of patients' symptoms. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-025483DOI Listing
February 2019

Frailty in the context of rehabilitation interventions for adults: protocol for a scoping review.

BMJ Open 2019 Feb 15;9(2):e024838. Epub 2019 Feb 15.

Toronto Rehabilitation Institute - University Health Network, Toronto, Ontario, Canada.

Introduction: Although a growing number of frail adults can benefit from rehabilitation services, few are included in rehabilitation services, and reasons for their exclusion are not well understood. To inform research directions in rehabilitation for all adults (aged 18 years and older), we will conduct a scoping review to describe (1) the characteristics of frail adult individuals included in rehabilitation interventions (eg, age range, inclusion and exclusion criteria that are applied), (2) the type of rehabilitation interventions that are used for individuals who are considered frail and (3) the commonly reported outcome measures used for these rehabilitation interventions.

Methods: This scoping review will be guided by Arksey and O'Malley's methodological framework. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-024838DOI Listing
February 2019

Therapist-guided and parent-guided internet-delivered behaviour therapy for paediatric Tourette's disorder: a pilot randomised controlled trial with long-term follow-up.

BMJ Open 2019 Feb 15;9(2):e024685. Epub 2019 Feb 15.

Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.

Objective: Behaviour therapy (BT) for Tourette's disorder (TD) and persistent (chronic) motor or vocal tic disorder (PTD) is rarely available. We evaluated the feasibility of adapting two existing BT protocols for TD/PTD (habit reversal training (HRT) and exposure and response prevention (ERP)) into a therapist-guided and parent-guided online self-help format.

Design: A pilot, single-blind, parallel group randomised controlled trial. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-024685DOI Listing
February 2019

Using specialist screening practitioners (SSPs) to increase uptake of bowel scope (flexible sigmoidoscopy) screening: results of a feasibility single-stage phase II randomised trial.

BMJ Open 2019 Feb 15;9(2):e023801. Epub 2019 Feb 15.

Research Department of Behavioural Science and Health, University College London, London, UK.

Objective: To determine the feasibility of specialist screening practitioners (SSPs) offering patient navigation (PN) to facilitate uptake of bowel scope screening (BSS) among patients who do not confirm or attend their appointment.

Design: A single-stage phase II trial.

Setting: South Tyneside District Hospital, Tyne and Wear, England, UK. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-023801DOI Listing
February 2019

Neuroblastoma with an unusual ovarian metastasis in a 5-year-old girl.

BMJ Case Rep 2019 Feb 15;12(2). Epub 2019 Feb 15.

Department of Paediatric Surgery, Noah's Ark Children's Hospital, University Hospital of Wales, Cardiff, UK.

Neuroblastoma metastasizing to the ovary is rare. We report the 10th case and review the scarce literature. A 5-year-old girl with stage M neuroblastoma presented with an upper abdominal and a pelvic mass. Read More

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http://dx.doi.org/10.1136/bcr-2018-226038DOI Listing
February 2019

Job-exposure matrix for historical exposures to rubber dust, rubber fumes and n-Nitrosamines in the British rubber industry.

Occup Environ Med 2019 Feb 16. Epub 2019 Feb 16.

Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.

Objectives: To develop a quantitative historical job-exposure matrix (JEM) for rubber dust, rubber fumes and n-Nitrosamines in the British rubber industry for 1915-2002 to estimate lifetime cumulative exposure (LCE) for a cohort of workers with 49 years follow-up.

Methods: Data from the EU-EXASRUB database-rubber dust (n=4157), rubber fumes (n=3803) and n-Nitrosamines (n=10 115) collected between 1977 and 2002-were modelled using linear mixed-effects models. Sample year, stationary/personal measurement, industry sector and measurement source were included as fixed explanatory variables and factory as random intercept. Read More

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http://dx.doi.org/10.1136/oemed-2018-105182DOI Listing
February 2019

A retrospective study on evaluation of anti-hypertensive drugs used in gestational hypertension.

Pak J Pharm Sci 2019 Jan;32(1):213-215

Department of Pharmacy Practice, School of Pharmaceutical Sciences, Vels University, Chennai, Tamil Nadu, India.

To evaluate the anti-hypertensive drugs used in pregnancy induced hypertension and to determine the safety of the anti-hypertensive drugs administered in gestational hypertensive patients. Pregnancy induced hypertension are very common in women and if unnoticed may lead to severe complications. The appropriate therapy is very much essential for the welfare of both the mother and the child. Read More

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January 2019

Chemical composition and antimicrobial and cytotoxic activities of Antidesm abunius L.

Pak J Pharm Sci 2019 Jan;32(1):153-163

Pharmacognosy Department, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.

It was deemed of interest to investigate Antidesm bunius aerial parts from phytochemical and biological points of view due to limited previous studies. Isolation and identification of phenolic compounds and evaluation of the potential antimicrobial and cytotoxic effects of A. bunius aerial parts was investigated. Read More

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January 2019

Formulation development and in vitro evaluation of fast dispersible, taste masked aceclofenac compacted pellets.

Pak J Pharm Sci 2019 Jan;32(1):117-123

Department of Pharmaceutics, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Karachi, Pakistan.

The objective of study was to develop Aceclofenac fast dispersible compacted pellets with improved taste and fast drug release. Pellets were prepared by extrusion spheronization technique followed by direct compression to make compacted pellets. Formulations were comprised of sucrose, mannitol, ac-di-sol, aspartame, pine apple flavor and magnesium stearate. Read More

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January 2019

Risk assessment scales to predict risk of hospital treated repeat self-harm: A cost-effectiveness modelling analysis.

J Affect Disord 2019 Feb 11;249:208-215. Epub 2019 Feb 11.

Centre for Mental Health and Safety and Greater Manchester Patient Safety Translational Research Centre, United Kingdom; Centre for Mental Health and Safety, University of Manchester, Jean McFarlane Building Oxford Road, Manchester M13 9PL, United Kingdom; Greater Manchester Mental Health NHS Foundation Trust, Manchester, United Kingdom.

Background: Risk scales are used widely for assessing individuals presenting to Emergency Departments (EDs) following self-harm. There is growing evidence that risk scales have limited clinical utility in identifying episodes at highest risk of repeat self-harm. However, their cost-effectiveness in terms of treatment allocation and subsequent repeat self-harm is unknown. Read More

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http://dx.doi.org/10.1016/j.jad.2019.02.036DOI Listing
February 2019

Spanish validation of the Barcelona TEMPS-A questionnaire in patients with bipolar disorder and general population.

J Affect Disord 2019 Feb 12;249:199-207. Epub 2019 Feb 12.

Bipolar and Depression Disorders Unit, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain. Electronic address:

Background: The Temperament Evaluation of the Memphis, Pisa, Paris, and San Diego (TEMPS-A) is a self-administered questionnaire intended to assess five affective temperaments: depressive, cyclothymic, hyperthymic, irritable and anxious. Our objective was to examine the psychometric properties of the TEMPS-A using a sample comprised by patients with bipolar disorder (BD) and healthy controls (HC) and to determine cut-off scores for each temperament.

Methods: Five hundred and ninety-eight individuals (327 BD and 271 HC) completed the TEMPS-A. Read More

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http://dx.doi.org/10.1016/j.jad.2019.02.037DOI Listing
February 2019

Evaluation of the influence of temperature and relative humidity on the permeability of four films to the fumigant dimethyl disulfide.

J Environ Manage 2019 Feb 14;236:687-694. Epub 2019 Feb 14.

State Key Laboratory for Biology of Plant Disease and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing, 100193, China. Electronic address:

Dimethyl disulfide (DMDS) is an alternative fumigant to methyl bromide that was phased out globally due to its stratospheric ozone-depleting properties. Covering the surface of the soil with a plastic tarpaulin or 'barrier film' when using a soil fumigant is typically used to retain fumigants in the soil and to reduce emissions. Emission levels depend on the film's permeability, which varies mainly according to the film's material, the type of fumigant and the environmental conditions. Read More

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http://dx.doi.org/10.1016/j.jenvman.2018.12.075DOI Listing
February 2019

Synthesis, crystal structure and biological evaluation of new phosphoramide derivatives as urease inhibitors using docking, QSAR and kinetic studies.

Bioorg Chem 2019 Feb 8;86:482-493. Epub 2019 Feb 8.

Department of Chemistry, Faculty of Science, Tarbiat Modares University, Tehran, Iran.

In an attempt to achieve a new class of phosphoramide inhibitors with high potency and resistance to the hydrolysis process against urease enzyme, we synthesized a series of bisphosphoramide derivatives (01-43) and characterized them by various spectroscopic techniques. The crystal structures of compounds 22 and 26 were investigated using X-ray crystallography. The inhibitory activities of the compounds were evaluated against the jack bean urease and were compared to monophosphoramide derivatives and other known standard inhibitors. Read More

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http://dx.doi.org/10.1016/j.bioorg.2019.01.064DOI Listing
February 2019

Mucoepidermoid carcinoma of the head and neck in children.

Int J Pediatr Otorhinolaryngol 2019 Feb 10;120:93-99. Epub 2019 Feb 10.

Department of Otolaryngology & Communication Enhancement, Boston Children's Hospital, Boston, MA, 02115, United States; Department of Otolaryngology, Harvard Medical School, Boston, MA, 02115, United States. Electronic address:

Introduction: Mucoepidermoid carcinoma is a rare malignant salivary gland neoplasm in the pediatric population. Few studies have discussed best practice with respect to diagnosis and treatment in children.

Objective: To present our institution's experience with the evaluation and management of pediatric mucoepidermoid carcinoma of the head and neck. Read More

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http://dx.doi.org/10.1016/j.ijporl.2019.02.020DOI Listing
February 2019

Relationship between otorhinologic trauma and Attention Deficit Hyperactivity Disorder symptoms in children.

Int J Pediatr Otorhinolaryngol 2019 Feb 8;120:89-92. Epub 2019 Feb 8.

Department of Otorinolaryngology, Private Hatem Hospital, Gaziantep, Turkey.

Objevtives: Otorhinologic trauma is an important condition at the ear, nose and throat (ENT) outpatient clinic in children. Attention deficit hyperactivity disorder (ADHD) has been identified as a potential risk factor that may contribute to the incidence of traumatic injuries. The aim of the study was to investigate whether there is an association between otorhinologic trauma and ADHD symptoms in children. Read More

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http://dx.doi.org/10.1016/j.ijporl.2019.02.016DOI Listing
February 2019

Synthesis and evaluation of novel GSK-3β inhibitors as multifunctional agents against Alzheimer's disease.

Eur J Med Chem 2019 Feb 8;167:211-225. Epub 2019 Feb 8.

Institute of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan, 250012, PR China. Electronic address:

To target the multi-facets of Alzheimer's disease (AD), a series of novel GSK-3β inhibitors containing the 2,3-diaminopyridine moiety were designed and synthesized. The amide derivatives 5a-f showed moderate potency against GSK-3β with weak Cu, Zn and Al chelating ability. The imine derivatives 9a, 9b and 9e were potent GSK-3β inhibitors and selective Cuand Al chelators. Read More

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http://dx.doi.org/10.1016/j.ejmech.2019.02.001DOI Listing
February 2019

Use of Doppler Probe in Non-Variceal Upper-Gastrointestinal Bleeding is Less Costly and More Effective Than Standard of Care.

Clin Gastroenterol Hepatol 2019 Feb 14. Epub 2019 Feb 14.

Division of Gastroenterology and Liver Disease, Case Western Reserve University School of Medicine, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA.

Background & Aims: Upper gastrointestinal bleeding is a common emergency and rebleeding is associated with an increased risk of death. Proper assessment of high-risk lesions and appropriate endoscopic hemostasis are required for the best outcomes. The endoscopic Doppler probe exam (DPE) allows for a more complete assessment of the stigmata of hemorrhage, providing better evaluation of the need for endoscopic hemostasis and determination of its completeness. Read More

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http://dx.doi.org/10.1016/j.cgh.2019.02.016DOI Listing
February 2019

Evaluation of the effectiveness of green infrastructure on hydrology and water quality in a combined sewer overflow community.

Sci Total Environ 2019 Jan 31;665:69-79. Epub 2019 Jan 31.

Department of Earth, Atmospheric, and Planetary Sciences, Purdue University, West Lafayette, IN 47907, USA.

Evaluation of the effectiveness of green infrastructure (GI) practices on improving site hydrology and water quality and their associated cost could provide valuable information for decision makers when creating development/re-development strategies. In this study, a watershed scale rainfall-runoff model (the Long-Term Hydrologic Impact Analysis - Low Impact Development model, the L-THIA-LID 2.1 model) was enhanced to improve its simulation of urban water management practices including GI practices. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.01.416DOI Listing
January 2019

Promoting sustainability of manufacturing industry through the lean energy-saving and emission-reduction strategy.

Sci Total Environ 2019 Feb 7;665:23-32. Epub 2019 Feb 7.

Zcrubber Group Co. Ltd, Hangzhou 310018, China.

The energy-saving and emission reduction (ESER) strategy is a crucial measure for promoting the sustainability of manufacturing industry in green transition. Analyzing current practices and limitations of the ESER in the manufacturing industry, this paper proposes a new concept entitled lean energy-saving and emission-reduction (LESER) and an approach to effectively improve the energy efficiency and reduce waste emissions. This paper illustrates the definition of the LESER and establishes an implementation framework for LESER to improve the manufacturing process. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.02.069DOI Listing
February 2019

Gestational exposure to PM impairs vascularization of the placenta.

Sci Total Environ 2019 Feb 7;665:153-161. Epub 2019 Feb 7.

College of Environment and Resource, Research Center of Environment and Health, Shanxi University, Taiyuan, Shanxi 030006, PR China. Electronic address:

The placenta is the bridge that connects the developing fetus and mother and is the place where nutrient uptake, waste elimination and gas exchange occurs. Epidemiological studies indicate that fetal stress, such as gestational PM (particulate matter (PM) with diameter ≤ 2.5 μm) exposure, is a risk factor for abnormal placenta development that could induce adverse effects on the fetus. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.02.101DOI Listing
February 2019

A Strong, Tough, and Osteoconductive Hydroxyapatite Mineralized Polyacrylamide/Dextran Hydrogel for Bone Tissue Regeneration.

Acta Biomater 2019 Feb 14. Epub 2019 Feb 14.

Department of Materials Science and Engineering, Southern University of Science and Technology, Shenzhen, Guangdong 518055, China. Electronic address:

The design of hydrogels with adequate mechanical properties and excellent bioactivity, osteoconductivity, and capacity for osseointegration is essential to bone repair and regeneration. However, it is challenging to integrate all these properties into one bone scaffold. Herein, we developed a strong, tough, osteoconductive hydrogel by a facile one-step micellar copolymerization of acrylamide and urethacrylate dextran (Dex-U), followed by the in situ mineralization of hydroxyapatite (HAp) nanocrystals. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.02.019DOI Listing
February 2019

Oxidized alginate hydrogels with the GHK peptide enhance cord blood mesenchymal stem cell osteogenesis: a paradigm for metabolomics-based evaluation of biomaterial design.

Acta Biomater 2019 Feb 14. Epub 2019 Feb 14.

Biological Systems Engineering Laboratory, Department of Chemical Engineering & Chemical Technology, Imperial College London, London, UK. Electronic address:

Oxidized alginate hydrogels are appealing alternatives to natural alginate due to their favourable biodegradability profiles and capacity to self-crosslink with amine containing molecules facilitating functionalization with extracellular matrix cues, which enable modulation of stem cell fate, achieve highly viable 3-D cultures, and promote cell growth. Stem cell metabolism is at the core of cellular fate (proliferation, differentiation, death) and metabolomics provides global metabolic signatures representative of cellular status, being able to accurately identify the quality of stem cell differentiation. Herein, umbilical cord blood mesenchymal stem cells (UCB MSCs) were encapsulated in novel oxidized alginate hydrogels functionalized with the glycine-histidine-lysine (GHK) peptide and differentiated towards the osteoblastic lineage. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.02.017DOI Listing
February 2019

Hematopoietic stem cell transplantation for mucopolysaccharidoses; past, present, and future.

Biol Blood Marrow Transplant 2019 Feb 14. Epub 2019 Feb 14.

Nemours/ Alfred I. duPont Hospital for Children, Wilmington, DE, USA; Department of Pediatrics, Shimane University Faculty of Medicine, Shimane, Japan; Department of Pediatrics, Graduate School of Medicine, Gifu University, Gifu, Japan; Department of Pediatrics, Thomas Jefferson University, Philadelphia, PA. Electronic address:

Allogenic hematopoietic stem cell transplantation (HSCT) has been shown to be a treatment option for a selected group of patients with mucopolysaccharidoses (MPS) (MPS I, II, IVA, VI, and VII). Early diagnosis and timely referral to an expert in MPS are critical, followed by a complete examination and evaluation with a multidisciplinary team, including a transplant physician. Treatment recommendations for MPS are based on multiple factors such as biological, sociological, and financial effects. Read More

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http://dx.doi.org/10.1016/j.bbmt.2019.02.012DOI Listing
February 2019

A scoping review provided a framework for new ways of doing research through mobilizing collective intelligence.

J Clin Epidemiol 2019 Feb 14. Epub 2019 Feb 14.

INSERM, U1153 Epidemiology and Biostatistics Sorbonne Paris Cité Research Center (CRESS), Methods of Therapeutic Evaluation of Chronic Diseases Team (METHODS), Paris, F-75014 France; Paris Descartes University, Sorbonne Paris Cité, France; Centre d'Epidémiologie Clinique, Hôpital Hôtel Dieu, Assistance Publique des Hôpitaux de Paris, Paris, France.

Objective: New forms of research involving collective intelligence (CI) of diverse individuals mobilized through crowdsourcing is successfully emerging in various fields. This scoping review aimed to describe these methods across different fields and propose a framework for implementation.

Study Design And Setting: We searched seven electronic databases for reports describing projects that had mobilized CI with crowdsourcing. Read More

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http://dx.doi.org/10.1016/j.jclinepi.2019.02.007DOI Listing
February 2019

Clinical Value of Hernia Mesh Pathology Evaluation.

J Am Coll Surg 2019 Feb 14. Epub 2019 Feb 14.

Beverly Hills Hernia Center, Beverly Hills, CA. Electronic address:

Background: Hernia mesh removal is growing in demand. Meanwhile, there is no standard in handling the mesh specimen, nor is there any consensus on the clinical value of the surgical pathology findings.

Study Design: All hernia mesh specimens gathered from 2013-2018 were analyzed. Read More

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http://dx.doi.org/10.1016/j.jamcollsurg.2019.02.038DOI Listing
February 2019

Sequential administrations of trifluoroacetate induce tolerance to Palicourea maccgravii, a monofluoroacetate-containing plant, in calves.

Toxicon 2019 Feb 14. Epub 2019 Feb 14.

Departamento de Clínica e Cirurgia Veterinárias, Escola de Veterinária, Universidade Federal de Minas Gerais (UFMG), Avenida Antônio Carlos 6627, Belo Horizonte, MG, 30123-970, Brazil. Electronic address:

Monofluoroacetate (MFA) is considered one of the most toxic substances known. It is found naturally in plants, and causes sudden death syndrome in ruminants. Due to hyperacute evolution of poisoning and the absence of effective treatment, induction of resistance in animals might be the best tool to control MFA poisoning in ruminants. Read More

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http://dx.doi.org/10.1016/j.toxicon.2019.02.005DOI Listing
February 2019

The antipsychotic-like effects of clozapine in C57BL/6 mice exposed to cuprizone: decreased glial activation.

Behav Brain Res 2019 Feb 14. Epub 2019 Feb 14.

Beijing Tiantan Hospital, Capital Medical University, Advanced Innovation Center for Human Brain Protection, Capital Medical University, China National Clinical Research Center for Neurological Diseases, No. 119 South 4th Ring Road West, Fengtai District, Beijing, 100070, PR China. Electronic address:

Cuprizone (CPZ), a copper chelator that has been shown to selectively damage white matter, can induce a novel animal model to mimic some symptoms of schizophrenia. This study aimed to examine the effect of clozapine (CLZ) on behavioural changes induced by CPZ exposure and try to explore the underlying mechanisms. Behavioural abnormalities associated with feeding mice a 0. Read More

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http://dx.doi.org/10.1016/j.bbr.2019.02.026DOI Listing
February 2019

Ureido-modified carboxymethyl chitosan-graft-stearic acid polymeric nano-micelles as a targeted delivering carrier of clarithromycin for Helicobacter pylori: Preparation and in vitro evaluation.

Int J Biol Macromol 2019 Feb 14. Epub 2019 Feb 14.

College of Marine Life Sciences, Ocean University of China, 266003 Qingdao, China.

The effect of antibiotics in the stomach for curing Helicobacter pylori infection is hampered by the adverse gastric environment and low bioavailability of the administered drugs. Concerning these challenges, a polymeric nano-micelle was developed. Initially, carboxymethyl chitosan (CMCS) was hydrophobically modified with stearic acid (SA), and the obtained CMCS-g-SA co-polymers was further conjugated with urea to acquire U-CMCS-g-SA co-polymers. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.01.227DOI Listing
February 2019

HLA-B*14 allele predicts HIV-1 mother-to-child-transmission, in Salvador, Brazil.

Braz J Infect Dis 2019 Feb 14. Epub 2019 Feb 14.

Universidade Federal da Bahia, Complexo Hospitalar Prof. Edgard Santos, Laboratório de Pesquisa em Infectologia, Salvador, BA, Brazil; Universidade Federal da Bahia, Complexo Hospitalar Prof. Edgard Santos, Salvador, BA, Brazil; Universidade Federal da Bahia, Bahia, Departamento de Medicina, Salvador, BA, Brazil. Electronic address:

Background: Mother-to-child-transmission (MTCT) is the main route of HIV-1 infection in children. Genetic studies suggest HLA-B alleles play an important role on HIV-1 transmission, progression, and control of HIV-1 infection.

Objective: To evaluate which polymorphisms of HLA-B are involved in HIV-1 MTCT. Read More

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http://dx.doi.org/10.1016/j.bjid.2018.12.002DOI Listing
February 2019

The dark side of the (half) Moon.

Surv Ophthalmol 2019 Feb 14. Epub 2019 Feb 14.

Save Sight Institute, The University of Sydney, Sydney, Australia.

A 71-year-old man was referred to Neuro-Ophthalmology for evaluation of reading problems associated to pituitary adenoma. Perimetry showed a right temporal crescent syndrome ("half moon" syndrome) suggesting left occipital disease. Brain MRI, electroencephalogram and CSF examination (14-3-3 protein) were consistent with a diagnosis of Creutzfeldt-Jakob disease. Read More

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http://dx.doi.org/10.1016/j.survophthal.2019.02.001DOI Listing
February 2019

Defining a "High Volume" Radical Cystectomy Hospital: Where Do We Draw the Line?

Eur Urol Focus 2019 Feb 13. Epub 2019 Feb 13.

Department of Urology, Vattikuti Urology Institute, Henry Ford Hospital, Detroit, MI, USA.

Background: Centralization of radical cystectomy (RC) to "high volume" centers can lead to decreased morbidity but also limits access to care. In the context of centralization, there is a need to systematically define the hospital volume cutoffs for this procedure.

Objective: To systematically examine the effect of hospital volume on inpatient complications of RC for bladder cancer and to define a threshold to minimize RC morbidity. Read More

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http://dx.doi.org/10.1016/j.euf.2019.02.001DOI Listing
February 2019

In vitro retention efficiency of temporary type zinc oxide cement for orthodontic forced eruption.

Int Orthod 2019 Feb 13. Epub 2019 Feb 13.

University of Granada, Faculty of Medicine and Faculty of Odontology, Granada, Spain.

Objective: To assess the retention efficiency of three types of temporary zinc oxide cement trademarks on forced eruption using intracranal wire device.

Methods: An in vitro evaluation included intracanal wire device displacement and detachment at 50g load force for 120 days and then the retention resistance at maximum load force.

Results: All groups of temporary zinc oxide cements were efficient to support 50g load forces after 120 days. Read More

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http://dx.doi.org/10.1016/j.ortho.2019.01.020DOI Listing
February 2019

Nitro-fatty acids protect against steatosis and fibrosis during development of nonalcoholic fatty liver disease in mice.

EBioMedicine 2019 Feb 13. Epub 2019 Feb 13.

Department of Internal Medicine, Michigan Medicine, Ann Arbor, MI, USA. Electronic address:

Background: Nonalcoholic fatty liver disease (NAFLD) and resulting nonalcoholic steatohepatitis (NASH) are reaching global epidemic proportions. Lack of non-invasive diagnostic tools and effective therapies constitute two of the major hurdles for a bona fide treatment and a reversal of NASH progression and/or regression of the disease. Nitro-oleic acid (OA-NO) has been proven effective in multiple experimental models of inflammation and fibrosis. Read More

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http://dx.doi.org/10.1016/j.ebiom.2019.02.019DOI Listing
February 2019

Evaluation of GDF15 as a therapeutic target of cardiometabolic diseases in human: A Mendelian randomization study.

EBioMedicine 2019 Feb 13. Epub 2019 Feb 13.

Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong.

Background: Growth differentiation factor 15 (GDF15) is a key regulator of body weight in animals by regulating food intake. Its receptor, glial cell-derived neurotrophic factor receptor alpha-like (GFRAL), was identified recently. Pre-clinical studies showed that it is a promising therapeutic target for cardiometabolic diseases and anorexia/cachexia. Read More

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http://dx.doi.org/10.1016/j.ebiom.2019.02.021DOI Listing
February 2019

Development of Caco-2 cells-based gene reporter assays and evaluation of herb-drug interactions involving CYP3A4 and CYP2D6 gene expression.

Chem Biol Interact 2019 Feb 14. Epub 2019 Feb 14.

Programa de Pós-Graduação Em Farmácia, Centro de Ciências da Saúde, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil. Electronic address:

The indiscriminate use of medicinal plants and herbal medicinal products concomitantly with conventional drugs may result in herb-drug interactions that may lead to fluctuations in drug bioavailability, therapeutic failure, and/or toxic effects. CYP450 enzymes play an important role in drug biotransformation and herb-drug interactions. Thus, the aim of this study was to develop and apply Caco-2 cells-based gene reporter assays to study in vitro the potential occurrence of CYP3A4 and CYP2D6 gene expression modulation by standardized extracts of selected medicinal plants. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.01.030DOI Listing
February 2019

Psychogenic non-epileptic seizures treated with guided transcranial direct current stimulation: A case report.

Brain Stimul 2019 Jan 31. Epub 2019 Jan 31.

CHU Lille, Hôpital Fontan, Department of Psychiatry, F-59000, Lille, France; Univ. Lille, CNRS UMR-9193, SCALab - Sciences Cognitives et Sciences Affectives, France; Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.

Introduction: Psychogenic non-epileptic seizures (PNES) are paroxysms of either altered subjective or objective manifestations that may mimic epileptic seizures (ES), without abnormal neuronal epileptiform activity. In this report, we present the case of a 39-year-old woman with PNES and functional movement disorders, who was successfully treated with neuro-guided transcranial direct current stimulation (tDCS).

Methods: We used a PET-guided tDCS approach, as a hypometabolism of the frontal region was revealed by FDG TEP scan. Read More

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http://dx.doi.org/10.1016/j.brs.2019.01.019DOI Listing
January 2019

Palbociclib triggers apoptosis in bladder cancer cells by Cdk2-induced Rad9-mediated reorganization of the Bak.Bcl-xl complex.

Biochem Pharmacol 2019 Feb 14. Epub 2019 Feb 14.

Medical School and State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, China. Electronic address:

Palbociclib is a Cdk4/6 inhibitor approved for metastatic estrogen receptor-positive breast cancer. The drug is also under clinical evaluation for metastatic urothelial cancer and other solid tumors. Preclinical studies from multiple tumor types suggest that other factors also affect the sensitivity of individual tumors to Cdk4/6 inhibitor. Read More

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http://dx.doi.org/10.1016/j.bcp.2019.02.017DOI Listing
February 2019

Ten-year outcomes after Roux-en-Y gastric bypass and sleeve gastrectomy: an observational nonrandomized cohort study.

Surg Obes Relat Dis 2019 Jan 29. Epub 2019 Jan 29.

Endocrinology and Diabetes Department, Obesity Unit, Hospital Clinic de Barcelona, Barcelona, Spain; Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona, Spain; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Barcelona, Spain. Electronic address:

Background: Sleeve gastrectomy (SG) has replaced Roux-en-Y gastric bypass (RYGB) as the most commonly performed bariatric surgery procedure. Data on the long-term (up to 10 yr) outcomes after SG is scarce. No previous study has compared the long-term outcomes between RYGB and SG. Read More

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http://dx.doi.org/10.1016/j.soard.2019.01.020DOI Listing
January 2019

Speech-in-noise perception ability can be related to auditory efferent pathway function: a comparative study in reading impaired and normal reading children.

Braz J Otorhinolaryngol 2019 Jan 28. Epub 2019 Jan 28.

Iran University of Medical Sciences, School of Rehabilitation Sciences, Department of Audiology, Tehran, Iran.

Introduction: Deficient auditory processing can cause problems with speech perception and affect the development and evolution of reading skills. The efferent auditory pathway has an important role in normal auditory system functions like speech-in-noise perception, but there is still no general agreement on this.

Objective: To study the performance of the efferent auditory system in a group of children with reading impairment in comparison with normal reading and evaluation of its relationship with speech-in-noise perception. Read More

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http://dx.doi.org/10.1016/j.bjorl.2018.11.010DOI Listing
January 2019

Social support is associated with fewer reported symptoms and decreased treatment burden in adults with cystic fibrosis.

J Cyst Fibros 2019 Feb 13. Epub 2019 Feb 13.

University of Colorado Denver, United States.

Background: Although social support has been linked to a variety of health outcomes in those with and without chronic illness, this construct has rarely been studied in adults with cystic fibrosis (CF), who may face a unique set of clinical and psychosocial barriers. The current study explored the relationships between social support, mental health, physical health, treatment activity, and disease-specific quality of life in a sample of adults with CF.

Methods: Participants in the study included 250 adults with CF who took part in a larger longitudinal study. Read More

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http://dx.doi.org/10.1016/j.jcf.2019.01.013DOI Listing
February 2019

Evaluation of VITEK MS, Clin-ToF-II MS, Autof MS 1000 and VITEK 2 ANC card for identification of Bacteroides fragilis group isolates and antimicrobial susceptibilities of these isolates in a Chinese university hospital.

J Microbiol Immunol Infect 2019 Jan 4. Epub 2019 Jan 4.

Department of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China; Beijing Key Laboratory for Mechanisms Research and Precision Diagnosis of Invasive Fungal Diseases, Beijing, China. Electronic address:

Background And Purpose: Bacteroides fragilis group isolates are most frequently isolated anaerobic pathogens. This study aimed to evaluate the accuracy of VITEK MS, Clin-ToF-II MS, Autof MS 1000 and VITEK 2 ANC card on the identification of clinical B. fragilis group isolates, as well as to determine their antimicrobial susceptibilities. Read More

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http://dx.doi.org/10.1016/j.jmii.2018.12.009DOI Listing
January 2019
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