1,580,990 results match your criteria Evaluation & the Health Professions [Journal]


Artificial Intelligence in Clinical Decision Support: Challenges for Evaluating AI and Practical Implications.

Yearb Med Inform 2019 Apr 25. Epub 2019 Apr 25.

Macquarie University, Australian Institute of Health Innovation, Sydney, Australia.

Objectives: This paper draws attention to: i) key considerations for evaluating artificial intelligence (AI) enabled clinical decision support; and ii) challenges and practical implications of AI design, development, selection, use, and ongoing surveillance.

Method: A narrative review of existing research and evaluation approaches along with expert perspectives drawn from the International Medical Informatics Association (IMIA) Working Group on Technology Assessment and Quality Development in Health Informatics and the European Federation for Medical Informatics (EFMI) Working Group for Assessment of Health Information Systems.

Results: There is a rich history and tradition of evaluating AI in healthcare. Read More

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http://dx.doi.org/10.1055/s-0039-1677903DOI Listing

Artificial Intelligence in Primary Health Care: Perceptions, Issues, and Challenges.

Yearb Med Inform 2019 Apr 25. Epub 2019 Apr 25.

Department of Clinical & Experimental Medicine, University of Surrey, Guildford, Surrey, UK.

Background: Artificial intelligence (AI) is heralded as an approach that might augment or substitute for the limited processing power of the human brain of primary health care (PHC) professionals. However, there are concerns that AI-mediated decisions may be hard to validate and challenge, or may result in rogue decisions.

Objective: To form consensus about perceptions, issues, and challenges of AI in primary care. Read More

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http://dx.doi.org/10.1055/s-0039-1677901DOI Listing

Bio-compatible patient-specific elastic bolus for clinical implementation.

Phys Med Biol 2019 Apr 25. Epub 2019 Apr 25.

Seoul National University Hospital, Jongno-gu, Seoul, Korea (the Republic of).

We investigated two types of materials with very low Shore hardness, silicon rubber (Dragon Skin) and urethane liquid rubber (Clear Flex 30), for use in 3D printing patient-specific boluses. Boluses were 3D printed with these materials using two methods of casting and direct printing. These patient-specific boluses were designed for 3D-printed elaborate human phantoms and their biological, physical, and dosimetric properties were comprehensively assessed. Read More

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http://dx.doi.org/10.1088/1361-6560/ab1c93DOI Listing

Recent Advances in the Discovery and Delivery of TLR7/8 Agonists as Vaccine Adjuvants.

Authors:
David J Dowling

Immunohorizons 2018 Jul 2;2(6):185-197. Epub 2018 Jul 2.

Division of Infectious Diseases, Department of Medicine, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115

The need for new adjuvants is absolutely cardinal to the development of new vaccines and to further optimizing current immunization approaches. However, only a few classes of adjuvants are presently incorporated in vaccines approved for human use. Recent advances in the discovery and delivery of TLR agonists as vaccine adjuvants have begun to open up a new toolbox for vaccinologists. Read More

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http://dx.doi.org/10.4049/immunohorizons.1700063DOI Listing

Association of bifid epiglottis and laryngeal web with Bardet-Biedl syndrome: A case report.

Int J Pediatr Otorhinolaryngol 2019 Apr 17;122:138-140. Epub 2019 Apr 17.

Department of Otolaryngology - Head and Neck Surgery, CHU de Québec- Centre Hospitalier Universitaire de Québec, Quebec City, QC, Canada. Electronic address:

Bardet-Biedl syndrome (BBS) is a rare autosomal-recessive disease characterized by rod-cone dystrophy, obesity, postaxial polydactyly, cognitive impairment, hypogonadism and renal abnormalities. Bifid epiglottis and anterior laryngeal web are rare congenital anomalies and are often constituent of polymalformation syndromes. We report a case of a 9-month-old patient initially referred in otolaryngology (ENT) for dysphonia and recurrent respiratory infections. Read More

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http://dx.doi.org/10.1016/j.ijporl.2019.04.019DOI Listing

Muscle Mass, Density, and Strength Are Necessary to Diagnose Sarcopenia in Patients With Gastric Cancer.

J Surg Res 2019 Apr 22;241:141-148. Epub 2019 Apr 22.

Department of Gastrointestinal Surgery, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China. Electronic address:

Background: Accurate evaluation of muscle strength and function is difficult. Commonly known as sarcopenia, skeletal muscle loss is closely correlated with the prognosis of patients diagnosed with gastric cancer (GC). We wondered the correlation between skeletal muscle measures combined with computed tomography and grip strength (GS) and short-term outcomes after radical gastrectomy (RG) in patients with GC. Read More

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http://dx.doi.org/10.1016/j.jss.2019.03.022DOI Listing

Expression of plasma microRNA-145-5p and its correlation with clinical features in patients with refractory epilepsy.

Epilepsy Res 2019 Apr 19;154:21-25. Epub 2019 Apr 19.

Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310009, China. Electronic address:

Purpose: The potential of microRNAs (miRNAs) as biomarkers has been explored in various brain diseases, including epilepsy. In this study, we are aiming to analyze the aberrant expression of miRNA-145-5p in patients with refractory epilepsy, and to further explore the correlation with clinical features.

Methods: The study cohort comprised 40 patients with refractory epilepsy and 42 healthy controls. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2019.04.010DOI Listing

Development and validation of a highly sensitive LC-MS/MS method for in vitro measurement of histamine concentration.

J Pharm Biomed Anal 2019 Apr 12;172:33-41. Epub 2019 Apr 12.

Department of Clinical Pharmacology, Inha University Hospital, Inha University School of Medicine, Incheon, Republic of Korea; Department of Internal Medicine, Inha University Hospital, Inha University School of Medicine, Incheon, Republic of Korea. Electronic address:

The basophil histamine release test (HRT) is an important in vitro diagnostic assay to evaluate immunoglobin E (IgE)-mediated allergic responses. In this study, a bioanalytical LC-MS/MS method was developed and validated to quantify histamine in the leukocyte suspension from human peripheral blood. The method used pre-column derivatization with phenylisothiocyanate (PITC) and the resulting phenylthiocarbamyl (PTC) histamine was analyzed by positive-ion electrospray ionization using the multiple reaction monitoring mode. Read More

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http://dx.doi.org/10.1016/j.jpba.2019.04.025DOI Listing

Quantitation of paclitaxel, and its 6-alpha-OH and 3-para-OH metabolites in human plasma by LC-MS/MS.

J Pharm Biomed Anal 2019 Apr 15;172:26-32. Epub 2019 Apr 15.

Cancer Therapeutics Program, UPMC Hillman Cancer Center, Pittsburgh, PA, United States; Division of Hematology-Oncology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States; Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA, United States. Electronic address:

We have developed a high performance liquid chromatography mass spectrometry method for quantitating paclitaxel and its 6-alpha-OH and 3-para-OH metabolites in 0.1 mL human plasma. After MTBE liquid-liquid extraction, chromatographic separation was achieved with a Phenomenex synergy polar reverse phase (4 μm, 2 mm × 50 mm) column and a gradient of 0. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07317085183240
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http://dx.doi.org/10.1016/j.jpba.2019.04.027DOI Listing
April 2019
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Vertebra-disc ratio as a new predictor for curve progression in early thoracic AIS with bracing treatment.

Clin Neurol Neurosurg 2019 Apr 15;181:82-88. Epub 2019 Apr 15.

Spine Surgery, Drum Tower Hospital, Nanjing University Medical School, Nanjing, Jiangsu Province, China. Electronic address:

Objectives: Previous studies have reported various predictors for curve progression in braced adolescent idiopathic scoliosis (AIS) patients. However, the reported predictors might be insufficient for patients with early AIS. The aim was to investigate whether the initial vertebra-disc ratio (VDR) could serve as an effective predictor for curve progression in early thoracic AIS (premenarchal and Risser 0) undergoing brace treatment. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03038467193011
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http://dx.doi.org/10.1016/j.clineuro.2019.04.012DOI Listing
April 2019
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Regional, socioeconomic and behavioural- impacts on consumer acceptability of beef in Northern Ireland, Republic of Ireland and Great Britain.

Meat Sci 2019 Apr 10;154:86-95. Epub 2019 Apr 10.

University College Cork, School of Food & Nutritional Sciences, Cork, Ireland.

This study was commissioned to assess if there are regional differences in the acceptability of beef between consumers from Northern Ireland (NI), Republic of Ireland (ROI) and Great Britain (GB). Palatability traits were affected by socioeconomic and behavioural factors such as preferred cooking endpoint, animal welfare, value, health aspects of beef product, ease of preparation as well as consumption frequency for specific cuts. "Willingness to pay" (WTP) was influenced by income, preferred cooking endpoint, value of beef product, ease of preparation and consumption frequency for frying steak. Read More

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http://dx.doi.org/10.1016/j.meatsci.2019.04.009DOI Listing

Dopamine D1-like receptors regulate agonistic components of pair bond maintenance behaviors in male titi monkeys (Callicebus cupreus).

Psychoneuroendocrinology 2019 Apr 13;106:259-267. Epub 2019 Apr 13.

California National Primate Research Center, University of California- Davis, One Shields Avenue, Davis, CA, 95616, USA; Animal Behavior Graduate Group, University of California- Davis, One Shields Avenue, Davis, CA, 95616, USA; Department of Psychology, University of California- Davis, One Shields Avenue, Davis, CA, 95616, USA.

Several neurobiological mechanisms are implicated in the formation of selective pair bonds in socially monogamous mammals, however much less is known about the mechanisms that underlie the long-term behavioral maintenance of these bonds. In prairie voles (Microtus ochrogaster), agonistic behavior that contributes to pair bond maintenance are regulated by dopamine activity at D1-like receptors (D1R) within the mesocorticolimbic system. Evidence suggests D1Rs similarly regulate the behavioral components of pair bond maintenance in socially monogamous titi monkeys (Callicebus cupreus); however, evaluation with behavioral pharmacology is necessary to evaluate this hypothesis. Read More

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http://dx.doi.org/10.1016/j.psyneuen.2019.04.012DOI Listing

Anti-diabetic and renoprotective effects of Cassiae Semen extract in the streptozotocin-induced diabetic rats.

J Ethnopharmacol 2019 Apr 22. Epub 2019 Apr 22.

Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, College of Pharmacy, Huazhong University of Science and Technology, Hangkong Road 13, Wuhan, 430030, China. Electronic address:

Ethnopharmacological Relevance: Cassiae Semen, the dried seed of Cassia obtusifolia L. (Leguminosae), is a traditional Chinese medicine. It has long been used as the treatment of diabetic hyperlipidemia and diabetic constipation in Traditional Chinese Medicine formulae. Read More

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http://dx.doi.org/10.1016/j.jep.2019.111904DOI Listing

Development of M10, myricetin-3-O-β-d-lactose sodium salt, a derivative of myricetin as a potent agent of anti-chronic colonic inflammation.

Eur J Med Chem 2019 Apr 16;174:9-15. Epub 2019 Apr 16.

School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, China; Innovation Center for Marine Drug Screening and Evaluation, Qingdao National Laboratory for Marine Science and Technology, Qingdao, 266071, China; Marine Biomedical Research Institute of Qingdao, Qingdao, 266071, China. Electronic address:

Myricetin is a natural dietary flavonoid compound with multiple activities, such as anti-oxidant, anti-inflammatory, anti-carcinogenic and anti-proliferative effects. However, myricetin exhibited substantial limitations, such as poor water-solubility, and low stability in body when it was administrated by oral. To solve these problems, we designed and synthesized a series of derivatives based on the structure of myricetin. Read More

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http://dx.doi.org/10.1016/j.ejmech.2019.04.031DOI Listing

Multi-objective green design model to mitigate environmental impact of construction of mega columns for super-tall buildings.

Sci Total Environ 2019 Apr 14;674:580-591. Epub 2019 Apr 14.

Department of Architectural Engineering, Yonsei University, Seoul 120-749, Republic of Korea. Electronic address:

The mega columns used in super-tall buildings are several meters in size; thus, a greater quantity of construction materials are required than for a general column. Considering the environmental impact, research on a green design model for super-tall buildings is necessary. This design model should minimize both CO emissions and cost in the mega-column construction and design phases with consideration of the member or building size. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.04.152DOI Listing

Reduction responsive liposomes based on paclitaxel-ss-lysophospholipid with high drug loading for intracellular delivery.

Int J Pharm 2019 Apr 22. Epub 2019 Apr 22.

School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, P R China. Electronic address:

In this report, a novel redox-responsive liposomes based on disulfide derivative paclitaxel-ss-lysophosphatidylcholine prodrug (PTX-ss-PC) with high PTX loading was developed for triggering drug release. First of all, PTX-ss-PC was synthesized by a facile esterification and verified by MS, H NMR and HPLC. After that, PTX-ss-PC derived liposomes (PTX-ss-PC liposomes) containing EPC:Chol:mPEG-DSPE components were prepared by the conventional film method. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2019.04.060DOI Listing

Role of Nrf2 in the antioxidation and oxidative stress induced developmental toxicity of honokiol in zebrafish.

Toxicol Appl Pharmacol 2019 Apr 22. Epub 2019 Apr 22.

New Drug Safety Evaluation Center, Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050, China; Beijing Union-Genious Pharmaceutical Technology Ltd., Beijing 100176, China. Electronic address:

Honokiol, the main bioactive component of Magnolia officinalis, has a variety of pharmacological actions. However, its toxicity has rarely been reported. According to previous studies performed in our laboratory, honokiol microemulsion has embryo developmental toxicity. Read More

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http://dx.doi.org/10.1016/j.taap.2019.04.016DOI Listing
April 2019
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Phylodynamic analyses of Brazilian antigenic variants of infectious bursal disease virus.

Infect Genet Evol 2019 Apr 22. Epub 2019 Apr 22.

Laboratório de Diagnóstico Molecular, Universidade Luterana do Brasil, Canoas, Rio Grande do Sul, Brazil; Simbios Biotecnologia, Cachoeirinha, Rio Grande do Sul, Brazil.

Infectious bursal disease virus (IBDV) is a very important pathogen to poultry production and it is classified into three main groups: classical virulent (cvIBDV), very virulent (vvIBDV) and antigenic variants (avIBDV). This last group is composed by five different genetic lineages (recently classified in genogroups G2, G4, G5, G6, and G7) distributed in specific regions around the world. Brazil is one of the biggest poultry producers in the world and the present study aimed to investigate the evolutionary history of avIBDVs of the genogroup G4 in Brazil. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15671348193005
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http://dx.doi.org/10.1016/j.meegid.2019.04.020DOI Listing
April 2019
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Chemosensitization and mitigation of Adriamycin-induced cardiotoxicity using combinational polymeric micelles for co-delivery of quercetin/resveratrol and resveratrol/curcumin in ovarian cancer.

Nanomedicine 2019 Apr 22. Epub 2019 Apr 22.

College of Pharmacy, Oregon State University; Department of Biomedical Engineering, Oregon Health and Sciences University. Electronic address:

This work looks to improve the efficacy of Adriamycin (ADR) while mitigating its cardiotoxicity using combinations of micellar resveratrol (R): quercetin (Q) (mRQ) or R: curcumin (C) (mRC) in healthy mice and ovarian cancer xenograft models. Ovarian cancer cells, ES2-Luc, or A2780ADR are inoculated in mice (n=4/group) and sorted into eight cohorts. Mice are treated weekly for 4weeks with ADR, ADR+mRQ, ADR+mRC, or controls (saline, empty micelles, ADR+EM, mRQ, or mRC). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15499634193007
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http://dx.doi.org/10.1016/j.nano.2019.03.011DOI Listing
April 2019
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Topical nanostructured lipid carriers/inorganic sunscreen combination for alleviation of all-trans retinoic acid-induced photosensitivity: Box-Behnken design optimization, in vitro and in vivo evaluation.

Eur J Pharm Sci 2019 Apr 22. Epub 2019 Apr 22.

Pharmacology Department, National Research Centre, El-Buhouth St., Dokki, Cairo 12622, Egypt.

All-trans retinoic acid is a natural retinoid and the physiologically active metabolite of vitamin A. The aim of the present study is to develop and optimize a nanostructured lipid carrier formulation to enhance the photostability of all-trans retinoic acid and alleviate its skin photosensitivity. Box-Behnken design was used for optimizing dependent variables such as particle size, zeta potential and viscosity. Read More

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http://dx.doi.org/10.1016/j.ejps.2019.04.019DOI Listing

Development of a reverse transcription-loop-mediated isothermal amplification (RT-LAMP) assay for the detection of porcine pegivirus.

J Virol Methods 2019 Apr 22. Epub 2019 Apr 22.

Department of Preventive Veterinary Medicine, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang, Jiangxi, 330045, China; Key Laboratory for Animal Health of Jiangxi Province, Nanchang, Jiangxi, 330045, China. Electronic address:

A simple and accurate reverse transcription-loop-mediated isothermal amplification (RT-LAMP) assay was developed and evaluated for the detection of porcine pegivirus (PPgV). The specific RT-LAMP primers targeting the conserved regions of NS5A genes were designed and used to detect PPgV. The optimal reaction parameter for RT-LAMP assay was 63℃ for 60 min. Read More

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http://dx.doi.org/10.1016/j.jviromet.2019.04.019DOI Listing

Evaluation of reproducibility of the cTnT immunoassay using quality control samples.

Clin Chim Acta 2019 Apr 22. Epub 2019 Apr 22.

Istituto di Fisiologia Clinica del CNR and CNR Spin-off QualiMedLab, Pisa, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.cca.2019.04.068DOI Listing

Group exposure and response prevention for college students with social anxiety: A randomized clinical trial.

J Clin Psychol 2019 Apr 25. Epub 2019 Apr 25.

Department of Human Development and Organization Studies, University of Florida, Gainesville, Florida.

Objective: Social anxiety increases college student drop-out risk and stifles employment opportunities. Group cognitive-behavioral therapy with exposure (CBT ERP) has the potential to alleviate campus resource strain but remains under-researched with college students. The present study investigated the efficacy of group CBT ERP in a randomized clinical trial on a college campus. Read More

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http://dx.doi.org/10.1002/jclp.22792DOI Listing

Evaluation of prices, availability and affordability of essential medicines in Lahore Division, Pakistan: A cross-sectional survey using WHO/HAI methodology.

PLoS One 2019 25;14(4):e0216122. Epub 2019 Apr 25.

Department of Pharmacy, School of Applied Sciences, University of Huddersfield, Huddersfield, West Yorkshire, United Kingdom.

Inadequate access to medicines affected by un-controlled prices is a major concern in developing countries, including Pakistan, which lacks comprehensive data on medicine prices. Thus, the objective of this study was to evaluate the prices, availability and affordability of essential medicines in Lahore division, Pakistan. The survey was undertaken from November, 2016 till March, 2017 by including 50 medicines, 14 from the WHO/HAI core list and 36 supplementary medicines from national essential medicine list (NEML) at public (n = 16) and private (n = 16) health facilities. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0216122PLOS
April 2019
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Retrospective evaluation of natural course in mild cases of Mycobacterium avium complex pulmonary disease.

PLoS One 2019 25;14(4):e0216034. Epub 2019 Apr 25.

Center for Infectious Diseases and Infection Control, School of Medicine, Keio University, Shinjuku, Tokyo, Japan.

Background: There is no proven management for mild cases of Mycobacterium avium complex (MAC) pulmonary disease, who do not immediately receive treatment and are managed with observation alone, because its long term-natural course, factors predictive of deterioration, and the effect of treating the disease remain unclear. Thus, we sought to investigate the natural course of mild cases of MAC pulmonary disease.

Methods: We conducted a multicenter retrospective study. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0216034PLOS
April 2019
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Preventing rheumatoid arthritis: Preferences for and predicted uptake of preventive treatments among high risk individuals.

PLoS One 2019 25;14(4):e0216075. Epub 2019 Apr 25.

Division of Rheumatology, Jewish General Hospital and Lady Davis Institute, and Department of Medicine, McGill University, Montreal, Canada.

Objective: To understand preferences for and estimate the likely uptake of preventive treatments currently being evaluated in randomized controlled trials with individuals at increased risk of developing rheumatoid arthritis (RA).

Methods: Focus groups were used to identify key attributes of potential preventive treatment for RA (reduction in risk of RA, how treatment is taken, chance of side effects, certainty in estimates, health care providers opinion). A web-based discrete choice experiment (DCE) was administered to people at-risk of developing RA, asking them to first choose their preferred of two hypothetical preventive RA treatments, and then between their preferred treatment and 'no treatment for now. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0216075PLOS

Calibration and evaluation of Quigley's hybrid housing price model in Microsoft Excel.

PLoS One 2019 25;14(4):e0215954. Epub 2019 Apr 25.

Department of Economics, University of Windsor, Windsor, Ontario, Canada.

Quigley derived his hybrid price model to improve the precision of predicted prices of sold homes by statistically merging data of resold homes in a repeat sales model with that of once-sold homes in a single sales hedonic price model. The literature has few applications of the hybrid model aside from those by Quigley and his collaborators. Two reasons for this underuse may be its computational intensiveness and its marginal empirical improvement in comparison with two other models. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215954PLOS
April 2019
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Towards interpretable machine learning models for diagnosis aid: A case study on attention deficit/hyperactivity disorder.

PLoS One 2019 25;14(4):e0215720. Epub 2019 Apr 25.

Department of Engineering Innovation Management, Faculty of Engineering, University of Mons, Mons, Belgium.

Attention Deficit/Hyperactivity Disorder (ADHD) is a neurodevelopmental disorder that has heavy consequences on a child's wellbeing, especially in the academic, psychological and relational planes. The current evaluation of the disorder is supported by clinical assessment and written tests. A definitive diagnosis is usually made based on the DSM-V criteria. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215720PLOS

VarWatch-A stand-alone software tool for variant matching.

PLoS One 2019 25;14(4):e0215618. Epub 2019 Apr 25.

Institute of Medical Informatics and Statistics, Kiel University, University Hospital Schleswig-Holstein, Kiel, Germany.

Massively parallel DNA sequencing of clinical samples holds great promise for the gene-based diagnosis of human inherited diseases because it allows rapid detection of putatively causative mutations at genome-wide level. Without additional evidence complementing their initial bioinformatics evaluation, however, the clinical relevance of such candidate genetic variants often remains unclear. In consequence, dedicated 'matching' services have been established in recent years that aim at the discovery of other, comparable case reports to facilitate individual diagnoses. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215618PLOS
April 2019
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Optimization of DNA extraction from human urinary samples for mycobiome community profiling.

PLoS One 2019 25;14(4):e0210306. Epub 2019 Apr 25.

Department of Surgery, Division of Urology, Cedars-Sinai Medical Center, Los Angeles, CA, United States of America.

Introduction: Recent data suggest the urinary tract hosts a microbial community of varying composition, even in the absence of infection. Culture-independent methodologies, such as next-generation sequencing of conserved ribosomal DNA sequences, provide an expansive look at these communities, identifying both common commensals and fastidious organisms. A fundamental challenge has been the isolation of DNA representative of the entire resident microbial community, including fungi. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210306PLOS

Evaluation of enterotoxin gene expression and enterotoxin production capacity of the probiotic strain Bacillus toyonensis BCT-7112T.

PLoS One 2019 25;14(4):e0214536. Epub 2019 Apr 25.

Department of Physiology, University of Veterinary Medicine Hannover, Foundation, Hannover, Germany.

The aim of the present study was to evaluate the safety of the probiotic strain Bacillus toyonensis BCT-7112T (active ingredient of Toyocerin) in relation to the enterotoxins haemolysin BL (Hbl) and the non-haemolytic enterotoxin (Nhe) by performing a quantitative reverse transcription (RT) real-time polymerase chain reaction (PCR) and a Western blot assay. The expression levels of the enterotoxin genes hblA, hblD, nheA, nheB and nheC, determined by means of RT real-time PCR in B. toyonensis, were lower than those in B. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214536PLOS

Details in the evaluation of circular RNA detection tools: Reply to Chen and Chuang.

PLoS Comput Biol 2019 Apr 25;15(4):e1006916. Epub 2019 Apr 25.

Institute of Fundamental and Frontier Sciences, University of Electronic Science and Technology of China, Chengdu, China.

In their comment, Chen and Chuang [1] pointed out several weak points of our recent paper [2]. Here we respond in detail to clarify the dataset we used in our work. We also discuss the three confounding factors they listed in their comment. Read More

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http://dx.doi.org/10.1371/journal.pcbi.1006916DOI Listing

On the utilization of polygenic risk scores for therapeutic targeting.

Authors:
Greg Gibson

PLoS Genet 2019 Apr 25;15(4):e1008060. Epub 2019 Apr 25.

Center for Integrative Genomics and School of Biological Sciences, Georgia Institute of Technology, Atlanta, Georgia, United States of America.

The promise of personalized genomic medicine is that knowledge of a person's gene sequences and activity will facilitate more appropriate medical interventions, particularly drug prescriptions, to reduce the burden of disease. Early successes in oncology and pediatrics have affirmed the power of positive diagnosis and are mostly based on detection of one or a few mutations that drive the specific pathology. However, genetically more complex diseases require the development of polygenic risk scores (PRSs) that have variable accuracy. Read More

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http://dx.doi.org/10.1371/journal.pgen.1008060DOI Listing

The Postoperative Speech Intelligibility Evaluation of Modified Z-Plasty Palatoplasty.

J Craniofac Surg 2019 Apr 18. Epub 2019 Apr 18.

Stomatological Hospital of Zunyi Medical University, Zunyi.

The aim of the present study is to test the feasibility of modified Z-plasty palatoplasty for cleft palate repair in surgeries and provide a new surgical method. Forty cleft palate patients were selected as participants and divided into 2 groups in random. Twenty patients in the experiment group were treated by modified Z-plasty palatoplasty while the other 20 patients in the control group by double opposing Z-plasty and Sommerlad palatoplasty. Read More

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http://Insights.ovid.com/crossref?an=00001665-900000000-9470
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http://dx.doi.org/10.1097/SCS.0000000000005546DOI Listing
April 2019
1 Read

Cartilage Trap-Door Flap Technique for Correction of High Nasal Septum Deflection.

J Craniofac Surg 2019 Apr 18. Epub 2019 Apr 18.

Department of Otolaryngology-Head and Neck Surgery, Kosin University College of Medicine, Busan, Korea.

Objective: To introduce a novel cartilage trap-door flap technique in endonasal septoplasty to correct high dorsal deviation of the cartilaginous septum, and confirm its effectiveness.

Design: Prospective observational study.

Setting: Medical center. Read More

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http://dx.doi.org/10.1097/SCS.0000000000005268DOI Listing

Major Structural Airway Pathologies of Patient Complaining Nasal Obstruction: Analysis of Frequency, Preoperative Complaints and Benefit from Surgery.

J Craniofac Surg 2019 Apr 20. Epub 2019 Apr 20.

Department of Plastic Surgery.

Introduction: Modern rhinoplasty has an aesthetic and a functional component that cannot be separated. Functional rhinoplasty generally concentrates on optimizing nasal airflow. Numerous techniques have been described for correction of each pathology. Read More

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http://dx.doi.org/10.1097/SCS.0000000000005554DOI Listing

Clinical Updates in Women's Health Care Summary: Acute Cough: Primary and Preventive Care Review.

Authors:
Julia Oat-Judge

Obstet Gynecol 2019 May;133(5):1075

Acute cough is a common presenting symptom in the ambulatory care setting in the United States. It imposes a significant symptom burden on patients and financial burden on the health care system. In most cases, acute cough is caused by a benign viral infection that will resolve without intervention. Read More

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http://dx.doi.org/10.1097/AOG.0000000000003239DOI Listing

Adnexal tumors in menopausal women: surgery or surveillance?

Menopause 2019 May;26(5):554-556

Department of Obstetrics and Gynecology, University of Kentucky, Lexington, Kentucky.

Asymptomatic ovarian tumors in menopausal women do not always require surgical removal. Experts recommend an initial evaluation with transvaginal ultrasound to help characterize the tumor's malignant risk. Low-risk tumors can be monitored with ultrasound, whereas high-risk tumors should be referred to a gynecologic oncologist. Read More

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http://dx.doi.org/10.1097/GME.0000000000001330DOI Listing

Is microcirculatory assessment ready for regular use in clinical practice?

Authors:
Daniel De Backer

Curr Opin Crit Care 2019 Jun;25(3):280-284

Department of Intensive Care, CHIREC Hospitals, Université Libre de Bruxelles, Brussels, Belgium.

Purpose Of Review: The present review discusses the current role of microcirculatory assessment in the hemodynamic monitoring of critically ill patients.

Recent Findings: Videomicroscopic techniques have demonstrated that microvascular perfusion is altered in critically ill patients, and especially in sepsis. These alterations are associated with organ dysfunction and poor outcome. Read More

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http://dx.doi.org/10.1097/MCC.0000000000000605DOI Listing

Assessment of neurocognitive function after cardiac arrest.

Curr Opin Crit Care 2019 Jun;25(3):234-239

Department of Clinical Sciences Lund, Neurology, Lund, Skane University Hospital, Lund University, Lund, Sweden.

Purpose Of Review: Impaired neurocognitive function is common in cardiac arrest survivors and the use of specific neurocognitive assessments are recommended in both clinical trials and daily practice. This review examines the most recent evidence to guide in the selection of neurocognitive outcome assessment tools after cardiac arrest.

Recent Findings: Neurocognitive impairment after cardiac arrest was recently reported as one of the major predictors for societal participation, highlighting the need for neurocognitive assessments. Read More

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http://dx.doi.org/10.1097/MCC.0000000000000607DOI Listing

DNP Program Faculty and Graduates' Knowledge and Use of QI and Safety Processes.

Nurse Educ 2019 Apr 23. Epub 2019 Apr 23.

Author Affiliations: Associate Professors (Drs Ossege and Tovar), College of Nursing, University of Kentucky, Lexington; Assistant Professor (Dr Farus-Brown), Ohio University, School of Nursing, Zanesville; Assistant Professor (Dr Zonsius), College of Nursing, Rush University, Chicago, Illinois; Clinical Assistant Professor (Dr Morrow), College of Nursing, Sacred Heart University, Fairfield, Connecticut.

Background: Across doctor of nursing practice (DNP) programs, wide variation exists for DNP project expectations and curricular integration of Quality and Safety Education for Nurses competencies.

Purpose: This study examined DNP project characteristics and compared knowledge, skills, and attitudes about quality improvement (QI) processes between DNP program faculty and graduates.

Methods: This descriptive study used a national convenience sample of DNP program faculty and graduates from multiple settings (N = 147) who completed an electronic survey of a modified version of the Quality Improvement Knowledge, Skills, and Attitudes Survey. Read More

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http://dx.doi.org/10.1097/NNE.0000000000000677DOI Listing

Neuro-Ophthalmic Symptoms of Primary Headache Disorders: Why the Patient With Headache May Present to Neuro-Ophthalmology.

Authors:
Stacy V Smith

J Neuroophthalmol 2019 Apr 23. Epub 2019 Apr 23.

Department of Neurology, Houston Methodist Neurological Institute, Houston, Texas; and Blanton Eye Institute, Houston Methodist Hospital, Houston, Texas.

Background: Primary headache disorders can cause many ophthalmic symptoms that lead many patients to present for neuro-ophthalmic evaluation. Neuro-ophthalmologists frequently encounter these patients in clinical practice.

Evidence Acquisition: A literature review was completed in PubMed using the following terms paired with "migraine" and "headache:" dry eye, eye pain, monocular diplopia, binocular diplopia, photophobia, visual field defect, tunnel vision, floaters, amaurosis fugax, transient visual obscuration, autonomic symptoms, anisocoria, visual snow, Alice in Wonderland syndrome, and palinopsia. Read More

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http://dx.doi.org/10.1097/WNO.0000000000000790DOI Listing

What Neuroradiologists Need to Know About Radiation Treatment for Neural Tumors.

Top Magn Reson Imaging 2019 Apr;28(2):37-47

University of Washington Medical Center, Department of Radiation Oncology, Seattle, WA.

Radiation oncologists and radiologists have a unique and mutually dependent relationship. Radiation oncologists rely on diagnostic imaging to locate the tumor and define the treatment target volume, evaluation of response to therapy, and follow-up. Accurate interpretation of post-treatment imaging requires diagnostic radiologists to have a basic understanding of radiation treatment planning and delivery. Read More

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http://dx.doi.org/10.1097/RMR.0000000000000196DOI Listing

The Reverse Oblique Supracondylar Humerus Fracture: Description of a Novel Fracture Pattern.

J Pediatr Orthop 2019 Apr 23. Epub 2019 Apr 23.

Department of Orthopaedic Surgery, Children's Hospital New Orleans/LSU Health Sciences Center, New Orleans, LA.

Background: Sagittal profile descriptions of supracondylar humerus fractures are limited. We describe a reverse oblique (RO) pattern in which the distal fragment has a prominent anterior spike that is displaced posterior to the proximal fragment. This pattern presents a challenge during closed manipulation utilizing traditional reduction maneuvers. Read More

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http://dx.doi.org/10.1097/BPO.0000000000001395DOI Listing

Balance Measures Over 12 Months in Individuals With Chronic Obstructive Pulmonary Disease.

J Cardiopulm Rehabil Prev 2019 May;39(3):E21-E24

School of Health and Social Care, Teesside University, Middleborough, UK (Dr Harrison); The Department of Respiratory Medicine, West Park Healthcare Centre (Drs Harrison, Goldstein, and Brooks and Ms Araujo), Department of Physical Therapy, University of Toronto (Harrison, Goldstein, and Brooks), and Department of Medicine, University of Toronto (Goldstein), Toronto, Ontario, Canada.

Purpose: To describe balance for 12 mo in people with chronic obstructive pulmonary disease (COPD).

Methods: Individuals with COPD completed the Berg Balance Scale (BBS), the Balance Evaluation Systems Test (BEST), and the Activities-Specific Balance Confidence (ABC) scale before pulmonary rehabilitation (PR), post-PR and at 3, 6, and 12 mo. If an acute exacerbation of COPD (AECOPD) occurred, balance measures were repeated after 7 d and 1 mo. Read More

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http://dx.doi.org/10.1097/HCR.0000000000000435DOI Listing
May 2019
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Is there a safety signal for dolutegravir and integrase inhibitors during pregnancy?

J Acquir Immune Defic Syndr 2019 Apr 19. Epub 2019 Apr 19.

Assistance Publique-Hopitaux de Paris, Hopitaux Universitaires Paris Centre, Centre Régional de Pharmacovigilance. 27 rue du Faubourg Saint-Jacques, 75014 Paris, France.

Background: Dolutegravir, an integrase strand transfer inhibitor (InSTI) is a major antiretroviral agent for HIV infection. Its use is promising, especially in low and middle-income countries, because of a high resistance barrier and a good safety profile. Very recently, a WHO safety signal has been raised regarding neural tube defects after first trimester exposure. Read More

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http://dx.doi.org/10.1097/QAI.0000000000002065DOI Listing

Effectiveness of family-based weight management interventions for children with overweight and obesity: an umbrella review.

JBI Database System Rev Implement Rep 2019 Apr 23. Epub 2019 Apr 23.

School of Health Sciences, Faculty of Health and Medicine, The University of Newcastle, Callaghan, Australia.

Objectives: The objective of the review was to synthesize the effectiveness and strategies used in family-based behavioral childhood obesity interventions in improving child weight-related outcomes.

Introduction: Family-based interventions are common practice in the treatment of childhood obesity. Research suggests that direct parental involvement can improve child weight-related outcomes. Read More

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http://Insights.ovid.com/crossref?an=01938924-900000000-9992
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http://dx.doi.org/10.11124/JBISRIR-2017-003695DOI Listing
April 2019
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Perspectives of Patients With Mental Illness on How to Better Teach and Evaluate Diversity Education in the National Health Service.

J Contin Educ Health Prof 2019 Apr 18. Epub 2019 Apr 18.

Dr. George: Lecturer in Clinical Communication Skills, Queen Mary University of London, and Bart's and the London School of Medicine and Dentistry, Queen Mary University of London, Robin Brook Centre, St Bartholomew's Hospital, London. Mr. Smith: Member of the Patient Advisory Forum, Health Education England, London, United Kingdom. Dr. O'Reilly: Senior Lecturer, University of Leicester and Research Consultant, NHS, Greenwood Institute of Child Health, Leicester, United Kingdom. Dr. Dogra: Professor of Psychiatry Education and Honorary Consultant in Child and Adolescent Psychiatry, University of Leicester, Greenwood Institute of Child Health, Leicester, United Kingdom.

Introduction: Diversity education is a mandatory requirement for all mental-health practitioners and health care professionals in the UK National Health Service. Wide variability exists in the development, delivery, and evaluation of diversity education across health care settings, with limited evidence to suggest the optimal approach for teaching this subject. This study aimed to explore the perspectives of patients with mental illness on how to better teach and evaluate diversity education in the National Health Service. Read More

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http://dx.doi.org/10.1097/CEH.0000000000000250DOI Listing

Update on spinal epidural abscess.

Curr Opin Infect Dis 2019 Jun;32(3):265-271

Division of Infectious Diseases, Mayo Clinic School of Medicine, Rochester, Minnesota, USA.

Purpose Of Review: Spinal epidural abscess (SEA) is still a rare but potentially very morbid infection of the spine. In recent years, the incidence has risen sharply but the condition remains a medical conundrum wrought with unacceptably long diagnostic delays. The outcome depends on timely diagnosis and missed opportunities can be associated with catastrophic consequences. Read More

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http://dx.doi.org/10.1097/QCO.0000000000000544DOI Listing
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