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J Electrocardiol 2021 Jun 1;67:103-106. Epub 2021 Jun 1.

Heart Hospital, Hamad Medical Corporation, Doha, Qatar.

Chest pain is still representing one of the most common and serious presentations to the emergency department worldwide. ECG is a crucial tool in evaluating patients with chest pain; however, only around 50% of patients with acute coronary syndrome (ACS) will have a diagnostic ECG upon their presentation; the rest may either have a completely normal ECG or what is called nonspecific ST segment and T wave (NSSTTW) changes, hence it is essential to recognize the subtle ECG changes and know its significance. One of the ECG changes that can be easily missed is when the T wave in V1 is upright, especially when it is either a Tall Upright T wave (TTV1) or a New Tall Upright T-wave (NTTV1). Read More

JMIR Serious Games 2021 Jun 15. Epub 2021 Jun 15.

Faculty of Nursing, Université de Montréal, Montreal, CA.

Background: Based on ethical and methodological arguments, numerous calls have been made to increase end-users' involvement in serious game (SG) development. Involving end-users is considered a way to give them power and control over an educational software designed for them. It can also help identify areas for improvement in SG design and improve its efficacy on targeted learning outcomes. Read More

J Laparoendosc Adv Surg Tech A 2021 Jun 14. Epub 2021 Jun 14.

Department of Colon and Rectal Surgery, Cedars-Sinai Medical Center, Los Angeles, California, USA.

Restorative proctocolectomy with ileal pouch-anal anastomosis (IPAA) is the procedure of choice for patients with ulcerative colitis and select patients with Crohn's disease. Minimally invasive techniques have been increasingly adopted including the transanal approach. However there remains a dearth of comparative data assessing the technical advantages and outcomes of a transanal approach to the IPAA against other minimally invasive techniques. Read More

Medicine (Baltimore) 2021 Jun;100(24):e26341

Department of Obstetrics and Gynecology, the First People's Hospital of Nantong, Nantong, Jiangsu, China.

Background: Hydatidiform mole (HM) is more common as molar pregnancy. It is a disease classified under the category of gestational trophoblastic diseases, which could metastasize after originating in the placenta. A majority of females suffering from molar pregnancies are curable by evacuating retained products of conception and the patient's fertility is preserved. Read More

Br J Nutr 2021 Jun 15:1-21. Epub 2021 Jun 15.

Universidade Federal do Piauí, Teresina, PI, Brazil.

Zinc deficiency compromises its biological functions, its effect on the immune system and its antiviral activity, increasing vulnerability to infectious diseases. This narrative review aims at presenting and discussing functional aspects and possible mechanisms involved in the potential role of zinc in the immune response and antiviral activity for COVID-19 prevention and control. The searches were conducted in PubMed and Science Direct databases, using clinical trials, experimental studies in animals and humans, case-control studies, case series, letters to the editor, and review articles published in English, without restrictions on year of publication. Read More

Adv Wound Care (New Rochelle) 2021 Jun 15. Epub 2021 Jun 15.

Tufts University School of Medicine, 12261, Molecular Physiology and Pharmacology, Boston, Massachusetts, United States.

Significance Non-healing wounds are an ever-growing global pandemic with mortality rates and management costs exceeding many common cancers. Although our understanding of the molecular and cellular factors driving wound healing continues to grow, standards for diagnosing and evaluating wounds remain largely subjective and experiential, while therapeutic strategies fail to consistently achieve closure and clinicians are challenged to deliver individualized care protocols. There is a need to apply precision medicine practices to wound care by developing evidence-based approaches, which are predictive, prescriptive, and personalized. Read More

J Neuroimaging 2021 Jun 15. Epub 2021 Jun 15.

UCSD Comprehensive Stroke Center, Department of Neurosciences, University of California San Diego, San Diego, California, USA.

Cerebral vessel recanalization therapy, either intravenous thrombolysis or mechanical thrombectomy, is the main treatment that can significantly improve clinical outcomes after acute ischemic stroke. The degree of recanalization and cerebral reperfusion of the ischemic penumbra are dependent on cerebral hemodynamics. Currently, the main imaging modalities to assess reperfusion are MRI and CT perfusion. Read More

Anesth Analg 2021 Jul;133(1):215-225

Department of Anesthesia, Pain Management, and Perioperative Medicine.

Background: Lack of access to safe and affordable anesthesia and surgical care is a major contributor to avoidable death and disability across the globe. Effective education initiatives are a viable mechanism to address critical skill and process gaps in perioperative teams. Vital Anaesthesia Simulation Training (VAST) aims to overcome barriers limiting widespread application of simulation-based education (SBE) in resource-limited environments, providing immersive, low-cost, multidisciplinary SBE and simulation facilitator training. Read More

J Cancer Res Ther 2021 Apr-Jun;17(2):455-462

Department of Radiation Oncology, RMLIMS, Lucknow, Uttar Pradesh, India.

Purpose: To classify the available plan evaluation indices and compare the dosimetric suitability of these indices.

Materials And Methods: Available published plan evaluation indices were categorized. Conformity index (CI) into two groups, one group contains those CI formulas which do not consider critical structure and other group contains those CI formulas which consider planning target volume (PTV) coverage, normal tissue and critical structure sparing simultaneously. Read More

Clin Neuropsychol 2021 Jun 13:1-36. Epub 2021 Jun 13.

Department of Psychiatry and Education, Semel Institute of Neuroscience and Human Behavior, David Geffen School of Medicine, Los Angeles, CA, USA.

Given the high population prevalence of Autism Spectrum Disorder (ASD) and overlapping symptoms with medically complex groups, ASD is a common rule out diagnosis for neuropsychologists even when not identified in the referral or initial presenting concerns. This paper presents practical guidance to support neuropsychologists in their ability to accurately assess, diagnose, and/or rule out ASD, especially in patients with more subtle presentations. This paper combines clinical experience and empirical literature to highlight important assessment measures and related considerations, differential diagnostic considerations, common misconceptions about ASD and person/family characteristics, as well as variability in presentation and comorbidities that can obscure the diagnosis. Read More

J Matern Fetal Neonatal Med 2021 Jun 13:1-7. Epub 2021 Jun 13.

Complex Structure Neonatology Unit, Department of Public Health and Paediatric, University of Turin, Torino, Italy.

Preeclampsia (PE) is a gestational hypertensive syndrome characterized by a complex disease with variable clinical manifestation. An aspect of increased interest is the possible effect of PE on the mammary gland (and therefore on breast milk composition) considering that a mother's own milk is always considered the first choice for the nutrition of all neonates. Human milk (HM) is a unique food believed to contain biological factors involved in both short and long-term benefits. Read More

Nutr Cancer 2021 Jun 14:1-9. Epub 2021 Jun 14.

Department of Nutrition and Postgraduate Program on Food and Nutrition, Federal University of Paraná, Curitiba, Parana, Brazil.

Fasting associated with chemotherapy could improve the efficacy of anticancer treatments without increasing their adverse effects. We conducted a systematic review following the PRISMA Statement to summarize the evidence on the effects of fasting on treatment response of adults undergoing chemotherapy and make suggestions for the design of future clinical trials The search was performed on CENTRAL, PubMed/MEDLINE, LILACS and Embase. Randomized and non-randomized clinical trials evaluating the effects of fasting (above 12 h, at anytime) on treatment response of adult cancer patients undergoing chemotherapy were included. Read More

Gene Ther 2021 Jun 14. Epub 2021 Jun 14.

Department of Haematology, UCL Cancer Institute, University College London, London, WC1E 6DD, United Kingdom.

Hirschsprung disease (HSCR) is a congenital anomaly of the colon that results from failure of enteric nervous system formation, leading to a constricted dysfunctional segment of the colon with variable lengths, and necessitating surgical intervention. The underlying pathophysiology includes a defect in neural crest cells migration, proliferation and differentiation, which are partially explained by identified genetic and epigenetic alterations. Despite the high success rate of the curative surgeries, they are associated with significant adverse outcomes such as enterocolitis, fecal soiling, and chronic constipation. Read More

J Anesth Hist 2021 Mar 30;7(1):11-16. Epub 2020 Dec 30.

Division of Anesthesia and Pain Medicine, Istituto Nazionale Tumori - IRCCS - Fondazione Pascale, Via Semmola, 80100, Napoli, Italy. Electronic address:

Background: Within the history of intravenous anesthesia, barbiturates represent a chapter of considerable importance. Although the reference barbiturate thiopental had several limitations, it dominated the scene of the intravenous anesthesia until the mid-1980s, when propofol was introduced on the market. In the meantime, several barbiturate derivatives were placed on the market and abounded. Read More

Behav Sleep Med 2021 Jun 14:1-23. Epub 2021 Jun 14.

Department of Psychological Services, Sheffield Teaching Hospitals, UK.

: Depression and anxiety are prevalent mental health conditions in older adulthood. Despite sleep disturbance being a common comorbidity in late-life depression and anxiety, it is often discounted as a target for treatment. The current review aims to establish whether cognitive-behavioral therapy (CBT) is effective in treating concomitant sleep disturbance in depressed and anxious older adults and to review evidence supporting whether CBT interventions targeting anxiety and depression, or concurrent sleep disturbance, have the greatest effectiveness in this client group. Read More

Eur J Nucl Med Mol Imaging 2021 Jun 12. Epub 2021 Jun 12.

Department of Medical Imaging, Nuclear Medicine, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.

In the past decade, a growing body of literature has reported promising results for prostate-specific membrane antigen (PSMA)-targeted radionuclide imaging and therapy in prostate cancer. First clinical studies evaluating the efficacy of [Lu]Lu-PSMA radioligand therapy (PSMA-RLT) demonstrated favorable results in prostate cancer patients. [Lu]Lu-PSMA is generally well tolerated due to its limited side effects. Read More

J Burn Care Res 2021 Jun 12. Epub 2021 Jun 12.

Division of Plastic and Reconstructive Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA.

Introduction: Burn wound depth assessments are an important component of determining patient prognosis and making appropriate management decisions. Clinical appraisal of the burn wound by an experienced burn surgeon is standard of care but has limitations. IR thermography is a technology in burn care that can provide a non-invasive, quantitative method of evaluating burn wound depth. Read More

Pract Radiat Oncol 2021 Jun 9. Epub 2021 Jun 9.

Southern California Evidence-Based Practice Center, RAND Corporation, Santa Monica, California; Southern California Evidence Review Center, Keck School of Medicine, University of Southern California, Los Angeles, California.

Purpose: This evidence report synthesizes the available evidence on radiation therapy for brain metastases.

Methods And Materials: The literature search included PubMed, EMBASE, Web of Science, Scopus, CINAHL, clinicaltrials.gov, and published guidelines in July 2020; independently submitted data, expert consultation, and contacting authors. Read More

BMC Public Health 2021 Jun 12;21(1):1127. Epub 2021 Jun 12.

Division of Public Health Science, Institute of Health Sciences, Mid Sweden University, Sundsvall, Sweden.

Background: Irrational household storage of medicines is a world-wide problem, which triggers medicine wastage as well as its associated harms. This study aimed to include all available evidences from literature to perform a focused examination of the prevalence and factors associated with medicine storage and wastage among urban households. This systematic review and meta-analysis mapped the existing literature on the burden, outcomes, and affective socio-economic factors of medicine storage among urban households. Read More

Autoimmun Rev 2021 Jun 9:102865. Epub 2021 Jun 9.

Department of Medicine C, Wolfson Medical Center, Holon, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Background And Aims: The novel SARS-CoV-2 has been rattling the world since its outbreak in December 2019, leading to the COVID-19 pandemic. The learning curve of this new virus has been steep, with a global scientific community desperate to learn how the virus is transmitted, how it replicates, what cause such a wide spectrum of disease manifestations, causing none or few symptoms in some. Others are burdened by an intense immune response that resembles the cytokine storm syndrome (CSS), which leads to severe disease manifestations, often complicated by fatal acute respiratory distress syndrome and death. Read More

Complement Ther Med 2021 Jun 10;60:102748. Epub 2021 Jun 10.

NICM Health Research Institute, Western Sydney University, Penrith, NSW 2751, Australia.

The objective of this bibliometric review was to identify the volume, breadth, and characteristics of clinical studies evaluating Tai Chi published between January 2010 and January 2020. Five English and four Chinese language databases were searched. Following independent screening, 1018 eligible publications representing 987 studies were identified, which was a three-fold increase from the previous decade. Read More

Surg Obes Relat Dis 2021 Apr 28. Epub 2021 Apr 28.

Department of Orthopaedics, Rijnstate Hospital, Arnhem, The Netherlands. Electronic address:

Obesity increases the risk of osteoarthritis and the chance of needing joint replacement arthroplasty to reduce lower limb joint pain. Although nonsurgical weight loss interventions can reduce hip and knee joint pain, bariatric surgery may be a more feasible treatment option for people with severe obesity. However, it is unclear whether weight loss through bariatric surgery can positively influence hip and knee joint pain. Read More

MAbs 2021 Jan-Dec;13(1):1932230

Discovery & Development Technologies, Drug Disposition & Design, EMD Serono Research & Development Institute, Inc, Billerica, MA, USA.

Understanding the pharmacokinetic (PK) properties of a drug, such as clearance, is a crucial step for evaluating efficacy. The PK of therapeutic antibodies can be complex and is influenced by interactions with the target, Fc-receptors, anti-drug antibodies, and antibody intrinsic factors. A growing body of literature has linked biophysical properties of antibodies, particularly nonspecific-binding propensity, hydrophobicity and charged regions to rapid clearance in preclinical species and selected human PK studies. Read More

Environ Res 2021 Jun 8:111490. Epub 2021 Jun 8.

Key Laboratory of Ecosystem Network Observation and Modeling, Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing, 100101, China.

Sustainable remediation, which promotes the use of more sustainable practices during environmental clean-up activities, is an area of intense international development. While numerous indicators related to sustainable remediation assessment have been utilized and published in related academic literature, they are difficult to unify and vary in emphasis between countries. Following literature retrieval from CNKI, Springer, ScienceDirect, and Wiley Online databases, we present a systematic and bibliometric analysis of relevant national and international literature to define the most frequently considered indicators of sustainability, which play important roles in selecting remediation technologies or site management methods from a sustainability perspective. Read More

PLoS Comput Biol 2021 Jun 11;17(6):e1009022. Epub 2021 Jun 11.

Centro de Engenharia Biológica, Universidade do Minho, Braga, Portugal.

Chinese hamster ovary (CHO) cells are the leading platform for the production of biopharmaceuticals with human-like glycosylation. The standard practice for cell line generation relies on trial and error approaches such as adaptive evolution and high-throughput screening, which typically take several months. Metabolic modeling could aid in designing better producer cell lines and thus shorten development times. Read More

Acta Med Litu 2020 23;27(2):45. Epub 2020 Dec 23.

"A Message from the Editor-in-Chief", Acta medica Lituanica, 27(2), p. 45. Available at: https://www.journals.vu.lt/AML/article/view/21932 (Accessed: 15April2021).

A Message from the Editor-in-Chief This issue of Acta medica Lituanica is the result of further evolution: from now on, our journal is being published by the Vilnius University Press. Probably you noted changed design, but most changes are within the system of submission and publishing. All they serve the main goal - wider and more effective dissemination of knowledge. Read More

Percept Mot Skills 2021 Jun 10:315125211024212. Epub 2021 Jun 10.

Discipline of Exercise and Sports Science, Sydney School of Health Sciences, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW, Australia.

Affective responses and enjoyment of exercise mediate exercise adherence, but previous research findings have failed to examine nuances that may moderate this relationship. We examined the effects of exercise on affective and enjoyment responses during and post exercise through a systematic literature review and meta-regression analysis. We searched major databases up to July 9, 2020 for studies evaluating healthy adults' acute and chronic responses to exercise, using either of The Feeling Scale or Physical Activity Enjoyment Scales. Read More

ESMO Open 2021 Jun 7;6(4):100180. Epub 2021 Jun 7.

Department of Medical Oncology, University Hospital of Geneva (HUG), Geneva, Switzerland. Electronic address:

Squamous cell carcinoma of the rectum is a rare malignancy (0.3% of all rectal cancers), with no known risk factor. These tumours are assessed as rectal cancer using immunohistochemical and radiological tests, and certain criteria (localisation, relationship with neighbouring structures) have to be fulfilled to make the diagnosis. Read More

Foot Ankle Int 2021 Jun 10:10711007211015186. Epub 2021 Jun 10.

Hospital for Special Surgery, New York, NY, USA.

Background: Peroneal tendon injuries are a common cause of lateral ankle pain and instability. While the use of hamstring autograft has been proposed as a viable surgical option for peroneus brevis reconstruction, reported outcomes with this technique are limited in the literature. We present patient-reported and clinical outcomes for patients who underwent peroneus brevis reconstruction with hamstring autograft. Read More