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    663 results match your criteria Euthyroid Sick Syndrome

    1 OF 14

    [Euthyroid sick syndrome: an important clinical problem].
    Wiad Lek 2017 ;70(2 pt 2):376-385
    Klinika Chorob Wewnętrznych i Farmakologii Klinicznej Katedry Farmakologii Śląskiego Uniwersytetu Medycznego w Katowicach, Polska.
    Despite absence of thyroid disease, patients with non-thyroidal illness frequently have changes in serum thyroid hormone measurements that may suggest thyroid dysfunction. These abnormalities include low serum triiodothyronine, high reverse triiodothyronine and usually normal or inappropriately low thyrotropin and thyroxine levels. The degree of thyroid function impairment correlates with disease severity and low levels of thyroid hormones, particularly thyroxine, predict a poor prognosis. Read More

    Thyroid Dysfunctions in a Sample of Egyptian Children and Adolescents with Systemic Lupus Erythematosus: Relation to Disease Activity and Duration.
    Egypt J Immunol 2016 Jun;23(2):65-73
    Department of Pediatrics, Faculty of Medicine, Tanta University, Tanta, Egypt.
    Systemic lupus erythematosus (SLE) is a chronic, autoimmune, inflammatory disease affects any organ of the body, including the thyroid gland. Both hypothyroidism and hyperthyroidism have been found in SLE patients more frequently than general population. The aim of this study was to evaluate the frequency of autoimmune thyroid dysfunctions in juvenile SLE and its relation to disease activity and duration. Read More

    Subclinical hypothyroidism and the risk of chronic kidney disease in T2D subjects: A case-control and dose-response analysis.
    Medicine (Baltimore) 2017 Apr;96(15):e6519
    aDepartment of Endocrinology, Beijing Tongren Hospital, Capital Medical University, Beijing bDepartment of General Surgery, Weihaiwei People's Hospital, Weihai cCritical Care Medicine, Beijing Jiangong Hospital dBeijng Key Laboratory of Diabetes Research and Care, Beijing, China.
    Evidence indicated a positive association between subclinical hypothyroidism (SCH) and cardiovascular diseases. But the relationship between SCH and chronic kidney diseases (CKD) remains unclear. A case-control study was performed to ascertain this relationship followed by a meta-analysis. Read More

    N-Acetylcysteine Prevents Low T3 Syndrome and Attenuates Cardiac Dysfunction in a Male Rat Model of Myocardial Infarction.
    Endocrinology 2017 May;158(5):1502-1510
    Thyroid Section, Endocrine Division, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre 90035-003, Rio Grande do Sul, Brazil.
    Nonthyroidal illness syndrome (NTIS) affects patients with myocardial infarction (MI). Oxidative stress has been implicated as a causative factor of NTIS, and reversed via N-acetylcysteine (NAC). Male Wistar rats submitted to left anterior coronary artery occlusion received NAC or placebo. Read More

    Occult endocrine dysfunction in patients with cirrhosis of liver.
    J Family Med Prim Care 2016 Jul-Sep;5(3):576-580
    Department of Gastroenterology, Command Hospital, Chandimandir, Panchkula, Haryana, India.
    Background: Liver dysfunction leads to endocrine disturbance due to the alteration in protein metabolism or synthesis. We studied the presence of occult endocrine dysfunction in liver cirrhosis and compared the same with underlying etiology.

    Materials And Methods: We evaluated thirty patients with liver cirrhosis in this cross-sectional, observational study. Read More

    Low T3 syndrome is a strong prognostic predictor in diffuse large B cell lymphoma.
    Br J Haematol 2017 Apr 1;177(1):95-105. Epub 2017 Feb 1.
    Department of Haematology, the First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Collaborative Innovation Centre for Cancer Personalized Medicine, Nanjing, China.
    The aim of this study was to evaluate the prognostic effect of low triiodothyronine (T3) syndrome on patients with diffuse large B cell lymphoma (DLBCL). A hundred and eighty-eight patients with detailed thyroid hormone levels at diagnosis of DLBCL were enrolled. Low T3 syndrome was defined as a low serum free T3 (FT3) level with low or normal serum free tetraiodothyronine (FT4) and thyroid stimulating hormone levels. Read More

    Myocardial Inactivation of Thyroid Hormones in Patients with Aortic Stenosis.
    Thyroid 2017 May 12;27(5):738-745. Epub 2017 Apr 12.
    1 Heart Institute of the University of São Paulo Medical School , Sao Paulo, Brazil .
    Objective: The human heart expresses the type 2 deiodinase (D2) that activates thyroxine (T4) to triiodothyronine (T3). At the same time, the inactivating type 3 deiodinase (D3) has been found in a rat model of right ventricular hypertrophy. It is not known whether the human myocardium metabolizes thyroid hormone. Read More

    Impact of diabetic ketoacidosis on thyroid function tests in type 1 diabetes mellitus patients.
    Diabetes Metab Syndr 2017 Nov 14;11 Suppl 1:S57-S59. Epub 2016 Dec 14.
    Health Research Institute, Diabetes Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, 61357-15794, Iran. Electronic address:
    The aim of current study was to evaluate the function of thyroid during diabetic acidosis, just after the treatment and two weeks after the treatment. This was the analytic study. The study subjects included 20 patients, aged 18-36 years old, with type1 diabetes and diabetic ketoacidosis. Read More

    Usefulness of Serum Triiodothyronine (T3) to Predict Outcomes in Patients Hospitalized With Acute Heart Failure.
    Am J Cardiol 2017 Feb 16;119(4):599-603. Epub 2016 Nov 16.
    Division of Endocrinology, Winthrop-University Hospital, Mineola, New York.
    Thyroid hormone plays an important role in cardiac function. Low levels of serum triiodothyronine (T3) due to nonthyroidal illness syndrome may have adverse effects in heart failure (HF). This study was designed to assess the ability of T3 to predict in-hospital outcomes in patients with acute HF. Read More

    Free T3 to free T4 ratio less than 2.0 suggests low T3 syndrome rather than central hypothyroidism from the age of two to eighteen years.
    Endocr J 2017 Feb 22;64(2):213-219. Epub 2016 Dec 22.
    Division of Endocrinology and Metabolism, Tokyo Metropolitan Children's Medical Center, Tokyo, Japan.
    No serological cut-off exists to separate low T3 syndrome (LT) and central hypothyroidism (CH). The objective of this retrospective study was to propose such a cut-off. The first participant group comprised 52 patients from the age of six to twenty years. Read More

    Thyroid abnormalities in term infants with fungal sepsis.
    Rev Assoc Med Bras (1992) 2016 Sep;62(6):561-567
    Full Professor of Intensive Care/Neonatology at FMUSP and Instituto da Criança, HC-FMUSP, São Paulo, SP, Brazil.
    Objective:: To describe thyroid alterations in term newborns (TNB) with fungal sepsis during NICU hospitalization.

    Method:: The study included six TNB that during the clinical and laboratory manifestations of sepsis with positive cultures for fungus showed changes in thyroid hormones, called low T3 syndrome and low T3-T4 syndrome. TNB that could present hormonal changes caused by disease as those born to mothers with thyroid disease, or who had perinatal asphyxia and major surgeries were excluded. Read More

    Non-thyroidal illness syndrome in patients with cardiovascular diseases: A systematic review and meta-analysis.
    Int J Cardiol 2017 Jan 18;226:1-10. Epub 2016 Oct 18.
    Department of Endocrinology, Jinshan Hospital of Fudan University, Shanghai 201508, China. Electronic address:
    Background: Non-thyroidal illness syndrome (NTIS) is characterized by decreased serum triiodothyronine level without increased thyroid-stimulating hormone level during critical illness. The summary data on the prevalence of NTIS in cardiovascular patients are lacking, and its prognostic role in cardiovascular patients is also unclear.

    Methods: We performed a systematic review and meta-analysis to comprehensively determine the prevalence and the prognostic role of NTIS in cardiovascular patients. Read More

    Low T3 syndrome in neuromyelitis optica spectrum disorder: Associations with disease activity and disability.
    J Neurol Sci 2016 Nov 22;370:214-218. Epub 2016 Sep 22.
    Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea; Neuroscience Center, Samsung Medical Center, Seoul, Republic of Korea. Electronic address:
    Background: Neuromyelitis optica (NMO) sometimes coexists with serological marker-positive, non-organ-specific autoimmune disorders. We evaluated the prevalence of thyroid dysfunction and anti-thyroid antibodies in patients with NMO spectrum disorder (NMOSD) and investigated the associations between thyroid dysfunction/autoimmunity and clinical features of NMOSD.

    Methods: Forty-nine NMOSD patients with anti-aquaporin-4 antibody and 392 age- and sex-matched healthy controls were included. Read More

    Thyroxine increases Serca2 and Ryr2 gene expression in heart failure rats with euthyroid sick syndrome.
    Arch Endocrinol Metab 2016 Nov-Dec;60(6):582-586. Epub 2016 Oct 10.
    Departamento de Clínica Médica, Unidade de Pesquisa Experimental (Unipex), Faculdade de Medicina de Botucatu, Universidade Estadual Paulista (Unesp), Botucatu, SP, Brasil.
    Objective: The current study was aimed at analyzing sarcoplasmic reticulum Ca2+ ATPase (Serca2) and ryanodine receptor type 2 (Ryr2) gene expression in rats subjected to surgery that induced HF and were subsequently treated with T4 using physiological doses.

    Materials And Methods: HF was induced in 18 male Wistar rats by clipping the ascending thoracic aorta to generate aortic stenosis (HFS group), while the control group (9-sham) underwent thoracotomy. After 21 weeks, the HFS group was subdivided into two subgroups. Read More

    Abnormal thyroid hormones and non-thyroidal illness syndrome in obstructive sleep apnea, and effects of CPAP treatment.
    Sleep Med 2016 Jul 25;23:21-25. Epub 2016 Jul 25.
    Institute of Biomedicine and Molecular Immunology, National Research Council, Palermo, Italy. Electronic address:
    Objective: In obstructive sleep apnea (OSA), while both hypothyroidism and hyperthyroidism have been studied, the occurrence of non-thyroidal illness syndrome (NTIS) (normal thyroid stimulating hormone [TSH] with low triiodotironine) has not been investigated. We explored the occurrence of NTIS in patients with moderate to severe OSA and its relationship to the severity of nocturnal respiratory disorders. We also studied the occurrence of subclinical hypothyroidism (SH, ie, high TSH with normal thyroxine) in OSA and changes in circulating TSH, free triiodotironine (fT3) and free thyroxine (fT4) after CPAP treatment. Read More

    Thyroid function in multidrug-resistant tuberculosis patients with or without human immunodeficiency virus (HIV) infection before commencement of MDR-TB drug regimen.
    Afr Health Sci 2016 Jun;16(2):596-602
    Deaprtment of Chemical Pathology, University of Ibadan/University College Hospital, Ibadan, Nigeria.
    Background: Mycobacterium tuberculosis and human immunodeficiency virus (HIV) are known to cause abnormal thyroid function. There is little information on whether HIV infection aggravates alteration of thyroid function in patients with MDR-TB.

    Objectives: This study was carried out to determine if HIV co-infection alters serum levels of thyroid hormones (T3, T4) and thyroid stimulating hormone (TSH) in patients with MDR-TB patients and to find out the frequency of subclinical thyroid dysfunction before the commencement of MDR-TB therapy. Read More

    [The relation between the low T3 syndrome in the clinical course of myocardial infarction and heart failure].
    Pol Merkur Lekarski 2016 Jun;40(240):380-3
    Jagiellonian University Medical College, Krakow, Poland, John Paul II Hospital: Department of Coronary Disease and Heart Failure.
    It has been proven that either excess or deficiency of thyroid hormones has harmful influence on the cardiovascular system function. On the other hand, severe systemic conditions like myocardial infarction or severe heart failure may affect thyroid hormones secretion and their peripheral conversion, leading to low T3 syndrome. Amongst many mechanisms causing T4 to T3 conversion disturbances, important role plays decreased activity of D1 deiodinase and increased activity of D3 deiodinase. Read More

    Thyroid hormone: relevance to xenotransplantation.
    Xenotransplantation 2016 Jul 4;23(4):293-9. Epub 2016 Jul 4.
    Thomas E Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA, USA.
    Background: It has been well documented that the level of serum/plasma free triiodothyronine (fT3) falls rapidly following brain death or during certain surgical procedures, for example, heart surgery carried out on cardiopulmonary bypass. The level in patients following cardiopulmonary bypass usually recovers within 2 days.

    Methods: We have measured serum fT3 in healthy naïve baboons (n = 31), healthy naïve monkeys (n = 5), and after pig-to-baboon heterotopic heart xenotransplantation (xenoTx) (Group 1, n = 9), orthotopic liver xenoTx (Group 2, n = 10), artery patch xenoTx (Group 3, n = 9), and in monkey-to-monkey heterotopic heart alloTx (Group 4, n = 5). Read More

    SEVERE AMIODARONE-INDUCED BRADICARDIA CONCEALES SICK SINUS SYNDROME: CASE REPORT.
    Rev Med Chir Soc Med Nat Iasi 2016 Jan-Mar;120(1):110-3
    Sinus node dysfunction is one of the most common arrhythmias in elderly patients; it is usually associated with intermittent and variable symptoms, thus making it difficult to diagnose. We present the case of an elderly female patient with a personal history of atrial fibrillation treated for the last three years with amiodarone; she was admitted to the Geriatric Clinic for non-specific symptoms with onset two months previously for which she had already sought care in different medical services. Clinical examination showed severe bradycardia; ECG and Holter ECG on admission confirmed severe bradycardia, with a heart rate between 29 and 50 beats/min (bpm). Read More

    Euthyroid Sick Syndrome.
    Compr Physiol 2016 Mar 15;6(2):1071-80. Epub 2016 Mar 15.
    Section of Endocrinology, Diabetes and Nutrition, Department of Medicine, Boston University School of Medicine, Boston Medical Center, Boston, Massachusetts, USA.
    In this review, we discuss the characteristics, pathophysiology, and therapeutic implications of the euthyroid sick syndrome. Multiple mechanisms have been identified to contribute to the development of euthyroid sick syndrome, including alterations in the iodothyronine deiodinases, thyroid-stimulating hormone secretion, thyroid hormone binding to plasma protein, transport of thyroid hormone in peripheral tissues, and thyroid hormone receptor activity. The euthyroid sick syndrome appears to be a complex mix of physiologic adaptation and pathologic response to acute illness. Read More

    Thyroid function and cardiovascular events in chronic kidney disease patients.
    J Nephrol 2017 Apr 2;30(2):235-242. Epub 2016 Apr 2.
    Department of Nephrology, Gulhane School of Medicine, Ankara, Turkey.
    Background And Aims: Abnormalities of thyroid function are commonly seen in chronic kidney disease (CKD) patients. They are associated with adverse clinical conditions such as atherosclerosis, endothelial dysfunction, inflammation and abnormal blood pressure variability. We investigated the association between thyroid disorders and endothelial function, assessed by flow-mediated dilatation (FMD) and carotid intima-media thickness (CIMT), and cardiovascular events (CVE) in CKD patients. Read More

    Occult endocrine dysfunction in patients of cerebrovascular accident.
    Ann Indian Acad Neurol 2016 Jan-Mar;19(1):94-8
    Department of Neurology, Command Hospital, Chandimandir, Panchkula, Haryana, India.
    Background: Cerebrovascular disorders are common conditions leading to significant morbidity and mortality in the population. Occult endocrine disorders also contribute to the morbidity and we studied the prevalence of endocrine dysfunction in patients of cerebrovascular accident (CVA).

    Materials And Methods: We evaluated 30 patients of CVA (aged 18-75, admission within 72 h of symptoms and positive neuroimaging) in this prospective, observational study. Read More

    Relationship Between Circulating Thyroid-Stimulating Hormone, Free Thyroxine, and Free Triiodothyronine Concentrations and 9-Year Mortality in Euthyroid Elderly Adults.
    J Am Geriatr Soc 2016 Mar;64(3):553-60
    National Institute on Aging, Baltimore, Maryland.
    Objectives: To determine the association between plasma thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), and free thyroxine (FT4) levels and all-cause mortality in older adults who had levels of all three hormones in the normal range.

    Design: Longitudinal.

    Setting: Community-based. Read More

    Low T3 syndrome is a strong predictor of poor outcomes in patients with community-acquired pneumonia.
    Sci Rep 2016 Mar 1;6:22271. Epub 2016 Mar 1.
    Department of Infectious Diseases, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
    Low T3 syndrome was previously reported to be linked to poor clinical outcomes in critically ill patients. The aim of this study was to evaluate the predictive power of low T3 syndrome for clinical outcomes in patients with community-acquired pneumonia (CAP). Data for 503 patients were analyzed retrospectively, and the primary end point was 30-day mortality. Read More

    Antioxidant therapy improves non-thyroidal illness syndrome in uremic rats.
    Ren Fail 2016 19;38(4):514-20. Epub 2016 Feb 19.
    a Department of Nephrology, Second Affiliated Hospital , Nanchang University , Nanchang , China ;
    Background: The roles of antioxidant therapy on non-thyroidal illness syndrome (NTIS) in uremic rats is still unclear.

    Materials And Methods: Twenty-four Sprague-Dawley (SD) rats were randomly divided into blank, 5/6 nephrectomy (Nx), pyrrolidine dithiocarbamate (PDTC, 10 mg/100 g), sodium bicarbonate (SB, 0.1 g/100 g), N-acetylcysteine (NAC, 80 mg/100 g) and thyroid hormones (TH, levothyroxine 2 μg/100 g) groups. Read More

    [THYROID STIMULATING HORMONE LEVELS IN EUTHYROID WOMEN WITH POLYCYSTIC OVARY SYNDROME].
    Akush Ginekol (Sofiia) 2015 ;54(6):10-5
    Unlabelled: The purpose of this study was to analyze the relationship of the main hormonal and metabolic abnormalities in PCOS with different levels of TSH in the limits of its reference values.

    Material And Methods: The study involved 70 women with PCOS aged 16 to 39 years and BMI between 18.3 and 39. Read More

    Prevalence and Predictors of Thyroid Dysfunction in Patients with HIV Infection and Acquired Immunodeficiency Syndrome: An Indian Perspective.
    J Thyroid Res 2015 22;2015:517173. Epub 2015 Dec 22.
    Department of Endocrinology, Post Graduate Institute of Medical Education & Research (PGIMER) and Dr. Ram Manohar Lohia (RML) Hospital, 1 Baba Kharak Singh Marg, New Delhi 110001, India.
    Background. Predictors of thyroid dysfunction in HIV are not well determined. This study aimed to determine the prevalence and predictors of thyroid dysfunction in HIV infected Indians. Read More

    Dynamic neuroendocrine changes in critically ill patients with polytrauma.
    Neuro Endocrinol Lett 2015 ;36(5):498-503
    Laboratory of Human Endocrinology, Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava, Slovakia.
    Objective: Acute multiple-trauma induces activation of neuroendocrine system. Nonthyroidal illness syndrome (NTIS) is considered to be associated with adverse outcome in intensive care unit (ICU) patients. This study was aimed to assess dynamic changes of neuroendocrine hormones in patients with polytrauma and their association with the polytrauma score (PTS). Read More

    Nonthyroidal illnesses syndrome in full-term newborns with sepsis.
    Arch Endocrinol Metab 2015 Dec;59(6):528-34
    Departamento de Pediatria, FMUSP, São Paulo, SP, Brasil.
    Objective: To assess hormonal changes in nonthyroidal illness syndrome (NTIS) in full-term newborns (NT) with sepsis.

    Materials And Methods: We included 28 NT with sepsis divided into 2 groups according to the time of normalization of serum and clinical indicators of infection: group A(A), 16 NT with improvement in up to 8 days; and group B(B), 12 NT improvement after 8 days. Among the 28 NT, 15 NT progressed to septic shock, with 5 NT group A and 10 NT in group B. Read More

    Role of enteral nutrition in nonthyroidal illness syndrome: a retrospective observational study.
    BMC Endocr Disord 2015 Nov 4;15:69. Epub 2015 Nov 4.
    Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, 305 East Zhong Shan Road, Nanjing, 210002, China.
    Background: The nonthyroidal illness syndrome (NTIS) is prevalent among patients with enterocutaneous fistula and is associated with poor outcomes. The present study aimed to explore the role of enteral nutrition (EN) therapy on thyroid function among patients with enterocutaneous fistula and NTIS.

    Methods: We conducted a retrospective observational study among patients with enterocutaneous fistula between January 2013 and April 2014. Read More

    Case report: severe reversible cardiomyopathy associated with systemic inflammatory response syndrome in the setting of diabetic hyperosmolar hyperglycemic non-ketotic syndrome.
    BMC Cardiovasc Disord 2015 Oct 14;15:123. Epub 2015 Oct 14.
    Department of Internal Medicine, Texas Tech University Health Sciences Center, School of Medicine, 3601 4th St Stop 9410, Lubbock, TX, 79416, USA.
    Background: This case study features a woman who presented with clinical and laboratory findings consistent with hyperosmolar hyperglycemic non-ketotic syndrome (HHNS), systemic inflammatory response syndrome (SIRS), and non-thyroidal illness syndrome (NTIS) who was noted to have a transient decrease in myocardial function. To our knowledge, this is the first case discussing the overlapping pathophysiological mechanisms could increase susceptibility to SIRS-induced cardiomyopathy. It is imperative that this clinical question be investigated further as such a relationship may have significant clinical implications for prevention and future treatments, particularly in patients similar to the one presented in this clinical case. Read More

    Thyroid function status and its impact on clinical outcome in patients admitted to critical care.
    Pak J Med Sci 2015 Jul-Aug;31(4):915-9
    Faiza A. Qari, FRCP, ABIM. Department of Internal Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
    Objective: To analyze alterations in thyroid function and the correlation between results of thyroid function test and mortality in medical and surgical intensive care unit (ICU) patients. It also aimed to evaluate the effect of thyroid dysfunction in ICU patients and their need for mechanical ventilation (MV).

    Methods: A single-center, prospective, observational study was conducted on patients admitted to medical and surgical ICU between 2013-2014. Read More

    Sexual function and depressive symptoms in young women with thyroid autoimmunity and subclinical hypothyroidism.
    Clin Endocrinol (Oxf) 2016 Jun 19;84(6):925-31. Epub 2015 Oct 19.
    Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Katowice, Poland.
    Objective: The results of few studies conducted to date suggest an increased prevalence of sexual dysfunction in patients with thyroid disorders.

    Design: The aim of this study was to compare female sexual function and depressive symptoms between women with autoimmune thyroid disease and with mild thyroid failure.

    Patients: The study included four groups of young women: euthyroid women with Hashimoto's thyroiditis (Group 1), women with nonautoimmune subclinical hypothyroidism (Group 2), women with autoimmune subclinical hypothyroidism (Group 3) and healthy euthyroid females without thyroid autoimmunity (Group 4). Read More

    Left ventricular function by speckle-tracking echocardiography in patients with low-T3 syndrome and acute myocardial infarction.
    Medicina (Kaunas) 2015 1;51(4):209-16. Epub 2015 Aug 1.
    Behavioral Medicine Institute, Medical Academy, Lithuanian University of Health Sciences, Palanga, Lithuania.
    Background And Objective: Low-T3 syndrome is common in patients with acute myocardial infarction (AMI). Recent experimental and clinical data have suggested a potential negative impact of low-T3 syndrome on myocardial function in patients with AMI. The aim of this study was to assess left ventricular (LV) myocardial function in patients with low-T3 syndrome and to investigate the association between hormonal profile and the severity of LV dysfunction using speckle-tracking echocardiography (STE). Read More

    Thyroid Hormone Profile in Patients With Acute Coronary Syndrome.
    Iran Red Crescent Med J 2015 Jul 22;17(7):e26919. Epub 2015 Jul 22.
    Department of Internal Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
    Background: Thyroid hormone has the a major role in the cardiovascular system function and cardiac a As well as to maintain the cardiovascular homeostasis A slightly change ind thyroid status actually affects cardiovascular mortality hemodynamic. The background of this study was to define the prevalence of thyroid dysfunction in acute coronary syndrome (ACS).

    Objectives: The primary objective was to define the prevalence of thyroid dysfunction in acute coronary syndrome, including Non-ST Segment Elevation Myocardial Infarction (NSTEMI), ST-segment Elevation Myocardial Infarction (STEMI), and unstable angina groups. Read More

    Sodium selenite supplementation does not fully restore oxidative stress-induced deiodinase dysfunction: Implications for the nonthyroidal illness syndrome.
    Redox Biol 2015 Dec 9;6:436-45. Epub 2015 Sep 9.
    Thyroid Section, Endocrine Division, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil. Electronic address:
    Unlabelled: Nonthyroidal illness syndrome (NTIS) is marked by low T3 and high reverse T3 levels. The physiopathology is poorly understood but involves oxidative stress-induced disruption of the iodothyronine deiodinases, which activate or inactivate thyroid hormones. Selenium, an essential trace element, exerts antioxidant function mainly through the thioredoxin reductase (TRx) and glutathione peroxidase (GPx) redox-regulating systems. Read More

    Association of low baseline free thyroxin levels with progression of coronary artery calcification over 4 years in euthyroid subjects: the Kangbuk Samsung Health Study.
    Clin Endocrinol (Oxf) 2016 Jun 3;84(6):889-95. Epub 2015 Nov 3.
    Department of Endocrinology and Metabolism, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
    Objective: Overt and subclinical hypothyroidism are risk factors for atherosclerosis and cardiovascular diseases. It is unclear whether thyroid hormone levels within the normal range are also associated with atherosclerosis measured by coronary artery calcium (CAC).

    Context: This study aimed to examine the relationship between normal variations in thyroid function and changes in CAC. Read More

    Emerging pharmacotherapy for treatment of traumatic brain injury: targeting hypopituitarism and inflammation.
    Expert Opin Emerg Drugs 2015 18;20(4):583-96. Epub 2015 Jun 18.
    a 1 University of Messina, Department of Biological and Environmental Sciences , Viale Ferdinando Stagno D'Alcontres, 31 - 98166 Messina, Italy +390906765208 ;
    Introduction: Traumatic brain injury (TBI) is a common cause of morbidity and mortality in the developed world. In particular, TBI is an important cause of death and disability in young adults with consequences ranging from physical disabilities to long-term cognitive, behavioural, psychological and social defects.

    Areas Covered: There is a large body of evidence that suggest that TBI conditions may adversely affect pituitary function in both the acute and chronic phases of recovery. Read More

    Thyroid function in critically ill patients.
    Lancet Diabetes Endocrinol 2015 Oct 10;3(10):816-25. Epub 2015 Jun 10.
    Department of Endocrinology and Metabolism, Academic Medical Centre, University of Amsterdam, AZ, Amsterdam, Netherlands. Electronic address:
    Patients in the intensive care unit (ICU) typically present with decreased concentrations of plasma tri-iodothyronine, low thyroxine, and normal range or slightly decreased concentration of thyroid-stimulating hormone. This ensemble of changes is collectively known as non-thyroidal illness syndrome (NTIS). The extent of NTIS is associated with prognosis, but no proof exists for causality of this association. Read More

    The influence of end-stage liver disease and liver transplantation on thyroid hormones.
    Arq Gastroenterol 2015 Apr-Jun;52(2):124-8
    Departamento de Cirurgia do Aparelho Digestivo, UFPR, Curitiba, PR, Brasil.
    Background: Thyroid dysfunction has been reported in most chronic illnesses including severe liver disease. These defects in thyroid hormone metabolism result in the sick euthyroid syndrome, also known as low T3 syndrome.

    Objectives: Our objective was to evaluate the thyroid function in patients with end stage liver disease prior and after deceased donor liver transplantation and to correlate thyroid hormonal changes with the MELD score (Model for End stage Liver Disease). Read More

    Low T3 syndrome in canine babesiosis associated with increased serum IL-6 concentration and azotaemia.
    Vet Parasitol 2015 Jun 8;211(1-2):23-7. Epub 2015 May 8.
    Division of Parasitology, Department of Preclinical Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences, Ciszewskiego 8, 02-786 Warsaw, Poland.
    Low triiodothyronine (T3) syndrome, also named euthyroid sick syndrome or non-thyroidal illness syndrome, has been recognized in canine babesiosis caused by Babesia rossi, where it manifested by lowering of the serum thyrotropin (TSH), total thyroxin (TT4) and free thyroxin (FT4) concentrations. This syndrome has also been observed in critical diseases in humans and animals, and the severity of the disease is considered an important factor in lowering of thyroid hormone concentrations. Interleukin-6 (IL-6) plays a role in the development of low T3 syndrome by causing a decrease in deiodinases 1 and 2 activity and increased activity of deiodinase 3, enzymes involved in the conversion of thyroxin (T4) to T3. Read More

    The molecular basis of the non-thyroidal illness syndrome.
    J Endocrinol 2015 Jun 13;225(3):R67-81. Epub 2015 May 13.
    Department of Endocrinology and Metabolism Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    The 'sick euthyroid syndrome' or 'non-thyroidal illness syndrome' (NTIS) occurs in a large proportion of hospitalized patients and comprises a variety of alterations in the hypothalamus-pituitary-thyroid (HPT) axis that are observed during illness. One of the hallmarks of NTIS is decreased thyroid hormone (TH) serum concentrations, often viewed as an adaptive mechanism to save energy. Downregulation of hypophysiotropic TRH neurons in the paraventricular nucleus of the hypothalamus and of TSH production in the pituitary gland points to disturbed negative feedback regulation during illness. Read More

    Astrocyte Elevated Gene-1 (AEG-1) Contributes to Non-thyroidal Illness Syndrome (NTIS) Associated with Hepatocellular Carcinoma (HCC).
    J Biol Chem 2015 Jun 5;290(25):15549-58. Epub 2015 May 5.
    From the Departments of Human and Molecular Genetics and Massey Cancer Center, VCU Institute of Molecular Medicine, Virginia Commonwealth University, Richmond, Virginia 23298 and
    Non-thyroidal illness syndrome (NTIS), characterized by low serum 3,5,3'-triiodothyronine (T3) with normal l-thyroxine (T4) levels, is associated with malignancy. Decreased activity of type I 5'-deiodinase (DIO1), which converts T4 to T3, contributes to NTIS. T3 binds to thyroid hormone receptor, which heterodimerizes with retinoid X receptor (RXR) and regulates transcription of target genes, such as DIO1. Read More

    Endocrine dysfunction in patients of leprosy.
    Indian J Endocrinol Metab 2015 May-Jun;19(3):369-72
    Department of Endocrinology, Command Hospital (WC), Chandimandir, Panchkula, Haryana, India.
    Background: Leprosy is a chronic granulomatous disease and affects many internal organs in addition to the skin and peripheral nerves. Endocrine dysfunction is often silent and is often missed in patients of leprosy leading to significant morbidity. We studied the presence of occult endocrine disorders in leprosy patients and compared the same with disease parameters. Read More

    Endocrine dysfunction in sepsis: a beneficial or deleterious host response?
    Germs 2015 Mar 2;5(1):17-25. Epub 2015 Mar 2.
    MD, PhD, Associate Professor, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania; National Institute for Infectious Diseases "Prof. Dr. Matei Balş", Bucharest, Romania.
    Sepsis is a systemic, deleterious inflammatory host response triggered by an infective agent leading to severe sepsis, septic shock and multi-organ failure. The host response to infection involves a complex, organized and coherent interaction between immune, autonomic, neuroendocrine and behavioral systems. Recent data have confirmed that disturbances of the autonomic nervous and neuroendocrine systems could contribute to sepsis-induced organ dysfunction. Read More

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