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    649 results match your criteria Euthyroid Sick Syndrome

    1 OF 13

    Impact of diabetic ketoacidosis on thyroid function tests in type 1 diabetes mellitus patients.
    Diabetes Metab Syndr 2016 Dec 14. Epub 2016 Dec 14.
    Health Research Institute, Diabetes Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, 61357-15794, Iran. Electronic address:
    The aim of current study was to evaluate the function of thyroid during diabetic acidosis, just after the treatment and two weeks after the treatment. This was the analytic study. The study subjects included 20 patients, aged 18-36 years old, with type1 diabetes and diabetic ketoacidosis. Read More

    Thyroxine increases Serca2 and Ryr2 gene expression in heart failure rats with euthyroid sick syndrome.
    Arch Endocrinol Metab 2016 Nov-Dec;60(6):582-586. Epub 2016 Oct 10.
    Departamento de Clínica Médica, Unidade de Pesquisa Experimental (Unipex), Faculdade de Medicina de Botucatu, Universidade Estadual Paulista (Unesp), Botucatu, SP, Brasil.
    Objective: The current study was aimed at analyzing sarcoplasmic reticulum Ca2+ ATPase (Serca2) and ryanodine receptor type 2 (Ryr2) gene expression in rats subjected to surgery that induced HF and were subsequently treated with T4 using physiological doses.

    Materials And Methods: HF was induced in 18 male Wistar rats by clipping the ascending thoracic aorta to generate aortic stenosis (HFS group), while the control group (9-sham) underwent thoracotomy. After 21 weeks, the HFS group was subdivided into two subgroups. Read More

    Abnormal thyroid hormones and non-thyroidal illness syndrome in obstructive sleep apnea, and effects of CPAP treatment.
    Sleep Med 2016 Jul 25;23:21-25. Epub 2016 Jul 25.
    Institute of Biomedicine and Molecular Immunology, National Research Council, Palermo, Italy. Electronic address:
    Objective: In obstructive sleep apnea (OSA), while both hypothyroidism and hyperthyroidism have been studied, the occurrence of non-thyroidal illness syndrome (NTIS) (normal thyroid stimulating hormone [TSH] with low triiodotironine) has not been investigated. We explored the occurrence of NTIS in patients with moderate to severe OSA and its relationship to the severity of nocturnal respiratory disorders. We also studied the occurrence of subclinical hypothyroidism (SH, ie, high TSH with normal thyroxine) in OSA and changes in circulating TSH, free triiodotironine (fT3) and free thyroxine (fT4) after CPAP treatment. Read More

    Thyroid function in multidrug-resistant tuberculosis patients with or without human immunodeficiency virus (HIV) infection before commencement of MDR-TB drug regimen.
    Afr Health Sci 2016 Jun;16(2):596-602
    Deaprtment of Chemical Pathology, University of Ibadan/University College Hospital, Ibadan, Nigeria.
    Background: Mycobacterium tuberculosis and human immunodeficiency virus (HIV) are known to cause abnormal thyroid function. There is little information on whether HIV infection aggravates alteration of thyroid function in patients with MDR-TB.

    Objectives: This study was carried out to determine if HIV co-infection alters serum levels of thyroid hormones (T3, T4) and thyroid stimulating hormone (TSH) in patients with MDR-TB patients and to find out the frequency of subclinical thyroid dysfunction before the commencement of MDR-TB therapy. Read More

    [The relation between the low T3 syndrome in the clinical course of myocardial infarction and heart failure].
    Pol Merkur Lekarski 2016 Jun;40(240):380-3
    Jagiellonian University Medical College, Krakow, Poland, John Paul II Hospital: Department of Coronary Disease and Heart Failure.
    It has been proven that either excess or deficiency of thyroid hormones has harmful influence on the cardiovascular system function. On the other hand, severe systemic conditions like myocardial infarction or severe heart failure may affect thyroid hormones secretion and their peripheral conversion, leading to low T3 syndrome. Amongst many mechanisms causing T4 to T3 conversion disturbances, important role plays decreased activity of D1 deiodinase and increased activity of D3 deiodinase. Read More

    Thyroid hormone: relevance to xenotransplantation.
    Xenotransplantation 2016 Jul 4;23(4):293-9. Epub 2016 Jul 4.
    Thomas E Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA, USA.
    Background: It has been well documented that the level of serum/plasma free triiodothyronine (fT3) falls rapidly following brain death or during certain surgical procedures, for example, heart surgery carried out on cardiopulmonary bypass. The level in patients following cardiopulmonary bypass usually recovers within 2 days.

    Methods: We have measured serum fT3 in healthy naïve baboons (n = 31), healthy naïve monkeys (n = 5), and after pig-to-baboon heterotopic heart xenotransplantation (xenoTx) (Group 1, n = 9), orthotopic liver xenoTx (Group 2, n = 10), artery patch xenoTx (Group 3, n = 9), and in monkey-to-monkey heterotopic heart alloTx (Group 4, n = 5). Read More

    Rev Med Chir Soc Med Nat Iasi 2016 Jan-Mar;120(1):110-3
    Sinus node dysfunction is one of the most common arrhythmias in elderly patients; it is usually associated with intermittent and variable symptoms, thus making it difficult to diagnose. We present the case of an elderly female patient with a personal history of atrial fibrillation treated for the last three years with amiodarone; she was admitted to the Geriatric Clinic for non-specific symptoms with onset two months previously for which she had already sought care in different medical services. Clinical examination showed severe bradycardia; ECG and Holter ECG on admission confirmed severe bradycardia, with a heart rate between 29 and 50 beats/min (bpm). Read More

    Euthyroid Sick Syndrome.
    Compr Physiol 2016 Mar 15;6(2):1071-80. Epub 2016 Mar 15.
    Section of Endocrinology, Diabetes and Nutrition, Department of Medicine, Boston University School of Medicine, Boston Medical Center, Boston, Massachusetts, USA.
    In this review, we discuss the characteristics, pathophysiology, and therapeutic implications of the euthyroid sick syndrome. Multiple mechanisms have been identified to contribute to the development of euthyroid sick syndrome, including alterations in the iodothyronine deiodinases, thyroid-stimulating hormone secretion, thyroid hormone binding to plasma protein, transport of thyroid hormone in peripheral tissues, and thyroid hormone receptor activity. The euthyroid sick syndrome appears to be a complex mix of physiologic adaptation and pathologic response to acute illness. Read More

    Thyroid function and cardiovascular events in chronic kidney disease patients.
    J Nephrol 2016 Apr 2. Epub 2016 Apr 2.
    Department of Nephrology, Gulhane School of Medicine, Ankara, Turkey.
    Background And Aims: Abnormalities of thyroid function are commonly seen in chronic kidney disease (CKD) patients. They are associated with adverse clinical conditions such as atherosclerosis, endothelial dysfunction, inflammation and abnormal blood pressure variability. We investigated the association between thyroid disorders and endothelial function, assessed by flow-mediated dilatation (FMD) and carotid intima-media thickness (CIMT), and cardiovascular events (CVE) in CKD patients. Read More

    Occult endocrine dysfunction in patients of cerebrovascular accident.
    Ann Indian Acad Neurol 2016 Jan-Mar;19(1):94-8
    Department of Neurology, Command Hospital, Chandimandir, Panchkula, Haryana, India.
    Background: Cerebrovascular disorders are common conditions leading to significant morbidity and mortality in the population. Occult endocrine disorders also contribute to the morbidity and we studied the prevalence of endocrine dysfunction in patients of cerebrovascular accident (CVA).

    Materials And Methods: We evaluated 30 patients of CVA (aged 18-75, admission within 72 h of symptoms and positive neuroimaging) in this prospective, observational study. Read More

    Relationship Between Circulating Thyroid-Stimulating Hormone, Free Thyroxine, and Free Triiodothyronine Concentrations and 9-Year Mortality in Euthyroid Elderly Adults.
    J Am Geriatr Soc 2016 Mar;64(3):553-60
    National Institute on Aging, Baltimore, Maryland.
    Objectives: To determine the association between plasma thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), and free thyroxine (FT4) levels and all-cause mortality in older adults who had levels of all three hormones in the normal range.

    Design: Longitudinal.

    Setting: Community-based. Read More

    Low T3 syndrome is a strong predictor of poor outcomes in patients with community-acquired pneumonia.
    Sci Rep 2016 Mar 1;6:22271. Epub 2016 Mar 1.
    Department of Infectious Diseases, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
    Low T3 syndrome was previously reported to be linked to poor clinical outcomes in critically ill patients. The aim of this study was to evaluate the predictive power of low T3 syndrome for clinical outcomes in patients with community-acquired pneumonia (CAP). Data for 503 patients were analyzed retrospectively, and the primary end point was 30-day mortality. Read More

    Antioxidant therapy improves non-thyroidal illness syndrome in uremic rats.
    Ren Fail 2016 19;38(4):514-20. Epub 2016 Feb 19.
    a Department of Nephrology, Second Affiliated Hospital , Nanchang University , Nanchang , China ;
    Background: The roles of antioxidant therapy on non-thyroidal illness syndrome (NTIS) in uremic rats is still unclear.

    Materials And Methods: Twenty-four Sprague-Dawley (SD) rats were randomly divided into blank, 5/6 nephrectomy (Nx), pyrrolidine dithiocarbamate (PDTC, 10 mg/100 g), sodium bicarbonate (SB, 0.1 g/100 g), N-acetylcysteine (NAC, 80 mg/100 g) and thyroid hormones (TH, levothyroxine 2 μg/100 g) groups. Read More

    Akush Ginekol (Sofiia) 2015 ;54(6):10-5
    Unlabelled: The purpose of this study was to analyze the relationship of the main hormonal and metabolic abnormalities in PCOS with different levels of TSH in the limits of its reference values.

    Material And Methods: The study involved 70 women with PCOS aged 16 to 39 years and BMI between 18.3 and 39. Read More

    Prevalence and Predictors of Thyroid Dysfunction in Patients with HIV Infection and Acquired Immunodeficiency Syndrome: An Indian Perspective.
    J Thyroid Res 2015 22;2015:517173. Epub 2015 Dec 22.
    Department of Endocrinology, Post Graduate Institute of Medical Education & Research (PGIMER) and Dr. Ram Manohar Lohia (RML) Hospital, 1 Baba Kharak Singh Marg, New Delhi 110001, India.
    Background. Predictors of thyroid dysfunction in HIV are not well determined. This study aimed to determine the prevalence and predictors of thyroid dysfunction in HIV infected Indians. Read More

    Dynamic neuroendocrine changes in critically ill patients with polytrauma.
    Neuro Endocrinol Lett 2015 ;36(5):498-503
    Laboratory of Human Endocrinology, Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava, Slovakia.
    Objective: Acute multiple-trauma induces activation of neuroendocrine system. Nonthyroidal illness syndrome (NTIS) is considered to be associated with adverse outcome in intensive care unit (ICU) patients. This study was aimed to assess dynamic changes of neuroendocrine hormones in patients with polytrauma and their association with the polytrauma score (PTS). Read More

    Nonthyroidal illnesses syndrome in full-term newborns with sepsis.
    Arch Endocrinol Metab 2015 Dec;59(6):528-34
    Departamento de Pediatria, FMUSP, São Paulo, SP, Brasil.
    Objective: To assess hormonal changes in nonthyroidal illness syndrome (NTIS) in full-term newborns (NT) with sepsis.

    Materials And Methods: We included 28 NT with sepsis divided into 2 groups according to the time of normalization of serum and clinical indicators of infection: group A(A), 16 NT with improvement in up to 8 days; and group B(B), 12 NT improvement after 8 days. Among the 28 NT, 15 NT progressed to septic shock, with 5 NT group A and 10 NT in group B. Read More

    Role of enteral nutrition in nonthyroidal illness syndrome: a retrospective observational study.
    BMC Endocr Disord 2015 Nov 4;15:69. Epub 2015 Nov 4.
    Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, 305 East Zhong Shan Road, Nanjing, 210002, China.
    Background: The nonthyroidal illness syndrome (NTIS) is prevalent among patients with enterocutaneous fistula and is associated with poor outcomes. The present study aimed to explore the role of enteral nutrition (EN) therapy on thyroid function among patients with enterocutaneous fistula and NTIS.

    Methods: We conducted a retrospective observational study among patients with enterocutaneous fistula between January 2013 and April 2014. Read More

    Case report: severe reversible cardiomyopathy associated with systemic inflammatory response syndrome in the setting of diabetic hyperosmolar hyperglycemic non-ketotic syndrome.
    BMC Cardiovasc Disord 2015 Oct 14;15:123. Epub 2015 Oct 14.
    Department of Internal Medicine, Texas Tech University Health Sciences Center, School of Medicine, 3601 4th St Stop 9410, Lubbock, TX, 79416, USA.
    Background: This case study features a woman who presented with clinical and laboratory findings consistent with hyperosmolar hyperglycemic non-ketotic syndrome (HHNS), systemic inflammatory response syndrome (SIRS), and non-thyroidal illness syndrome (NTIS) who was noted to have a transient decrease in myocardial function. To our knowledge, this is the first case discussing the overlapping pathophysiological mechanisms could increase susceptibility to SIRS-induced cardiomyopathy. It is imperative that this clinical question be investigated further as such a relationship may have significant clinical implications for prevention and future treatments, particularly in patients similar to the one presented in this clinical case. Read More

    Thyroid function status and its impact on clinical outcome in patients admitted to critical care.
    Pak J Med Sci 2015 Jul-Aug;31(4):915-9
    Faiza A. Qari, FRCP, ABIM. Department of Internal Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
    Objective: To analyze alterations in thyroid function and the correlation between results of thyroid function test and mortality in medical and surgical intensive care unit (ICU) patients. It also aimed to evaluate the effect of thyroid dysfunction in ICU patients and their need for mechanical ventilation (MV).

    Methods: A single-center, prospective, observational study was conducted on patients admitted to medical and surgical ICU between 2013-2014. Read More

    Left ventricular function by speckle-tracking echocardiography in patients with low-T3 syndrome and acute myocardial infarction.
    Medicina (Kaunas) 2015 1;51(4):209-16. Epub 2015 Aug 1.
    Behavioral Medicine Institute, Medical Academy, Lithuanian University of Health Sciences, Palanga, Lithuania.
    Background And Objective: Low-T3 syndrome is common in patients with acute myocardial infarction (AMI). Recent experimental and clinical data have suggested a potential negative impact of low-T3 syndrome on myocardial function in patients with AMI. The aim of this study was to assess left ventricular (LV) myocardial function in patients with low-T3 syndrome and to investigate the association between hormonal profile and the severity of LV dysfunction using speckle-tracking echocardiography (STE). Read More

    Thyroid Hormone Profile in Patients With Acute Coronary Syndrome.
    Iran Red Crescent Med J 2015 Jul 22;17(7):e26919. Epub 2015 Jul 22.
    Department of Internal Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
    Background: Thyroid hormone has the a major role in the cardiovascular system function and cardiac a As well as to maintain the cardiovascular homeostasis A slightly change ind thyroid status actually affects cardiovascular mortality hemodynamic. The background of this study was to define the prevalence of thyroid dysfunction in acute coronary syndrome (ACS).

    Objectives: The primary objective was to define the prevalence of thyroid dysfunction in acute coronary syndrome, including Non-ST Segment Elevation Myocardial Infarction (NSTEMI), ST-segment Elevation Myocardial Infarction (STEMI), and unstable angina groups. Read More

    Sodium selenite supplementation does not fully restore oxidative stress-induced deiodinase dysfunction: Implications for the nonthyroidal illness syndrome.
    Redox Biol 2015 Dec 9;6:436-45. Epub 2015 Sep 9.
    Thyroid Section, Endocrine Division, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil. Electronic address:
    Unlabelled: Nonthyroidal illness syndrome (NTIS) is marked by low T3 and high reverse T3 levels. The physiopathology is poorly understood but involves oxidative stress-induced disruption of the iodothyronine deiodinases, which activate or inactivate thyroid hormones. Selenium, an essential trace element, exerts antioxidant function mainly through the thioredoxin reductase (TRx) and glutathione peroxidase (GPx) redox-regulating systems. Read More

    Emerging pharmacotherapy for treatment of traumatic brain injury: targeting hypopituitarism and inflammation.
    Expert Opin Emerg Drugs 2015 18;20(4):583-96. Epub 2015 Jun 18.
    a 1 University of Messina, Department of Biological and Environmental Sciences , Viale Ferdinando Stagno D'Alcontres, 31 - 98166 Messina, Italy +390906765208 ;
    Introduction: Traumatic brain injury (TBI) is a common cause of morbidity and mortality in the developed world. In particular, TBI is an important cause of death and disability in young adults with consequences ranging from physical disabilities to long-term cognitive, behavioural, psychological and social defects.

    Areas Covered: There is a large body of evidence that suggest that TBI conditions may adversely affect pituitary function in both the acute and chronic phases of recovery. Read More

    Thyroid function in critically ill patients.
    Lancet Diabetes Endocrinol 2015 Oct 10;3(10):816-25. Epub 2015 Jun 10.
    Department of Endocrinology and Metabolism, Academic Medical Centre, University of Amsterdam, AZ, Amsterdam, Netherlands. Electronic address:
    Patients in the intensive care unit (ICU) typically present with decreased concentrations of plasma tri-iodothyronine, low thyroxine, and normal range or slightly decreased concentration of thyroid-stimulating hormone. This ensemble of changes is collectively known as non-thyroidal illness syndrome (NTIS). The extent of NTIS is associated with prognosis, but no proof exists for causality of this association. Read More

    The influence of end-stage liver disease and liver transplantation on thyroid hormones.
    Arq Gastroenterol 2015 Apr-Jun;52(2):124-8
    Departamento de Cirurgia do Aparelho Digestivo, UFPR, Curitiba, PR, Brasil.
    Background: Thyroid dysfunction has been reported in most chronic illnesses including severe liver disease. These defects in thyroid hormone metabolism result in the sick euthyroid syndrome, also known as low T3 syndrome.

    Objectives: Our objective was to evaluate the thyroid function in patients with end stage liver disease prior and after deceased donor liver transplantation and to correlate thyroid hormonal changes with the MELD score (Model for End stage Liver Disease). Read More

    Low T3 syndrome in canine babesiosis associated with increased serum IL-6 concentration and azotaemia.
    Vet Parasitol 2015 Jun 8;211(1-2):23-7. Epub 2015 May 8.
    Division of Parasitology, Department of Preclinical Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences, Ciszewskiego 8, 02-786 Warsaw, Poland.
    Low triiodothyronine (T3) syndrome, also named euthyroid sick syndrome or non-thyroidal illness syndrome, has been recognized in canine babesiosis caused by Babesia rossi, where it manifested by lowering of the serum thyrotropin (TSH), total thyroxin (TT4) and free thyroxin (FT4) concentrations. This syndrome has also been observed in critical diseases in humans and animals, and the severity of the disease is considered an important factor in lowering of thyroid hormone concentrations. Interleukin-6 (IL-6) plays a role in the development of low T3 syndrome by causing a decrease in deiodinases 1 and 2 activity and increased activity of deiodinase 3, enzymes involved in the conversion of thyroxin (T4) to T3. Read More

    The molecular basis of the non-thyroidal illness syndrome.
    J Endocrinol 2015 Jun 13;225(3):R67-81. Epub 2015 May 13.
    Department of Endocrinology and Metabolism Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    The 'sick euthyroid syndrome' or 'non-thyroidal illness syndrome' (NTIS) occurs in a large proportion of hospitalized patients and comprises a variety of alterations in the hypothalamus-pituitary-thyroid (HPT) axis that are observed during illness. One of the hallmarks of NTIS is decreased thyroid hormone (TH) serum concentrations, often viewed as an adaptive mechanism to save energy. Downregulation of hypophysiotropic TRH neurons in the paraventricular nucleus of the hypothalamus and of TSH production in the pituitary gland points to disturbed negative feedback regulation during illness. Read More

    Astrocyte Elevated Gene-1 (AEG-1) Contributes to Non-thyroidal Illness Syndrome (NTIS) Associated with Hepatocellular Carcinoma (HCC).
    J Biol Chem 2015 Jun 5;290(25):15549-58. Epub 2015 May 5.
    From the Departments of Human and Molecular Genetics and Massey Cancer Center, VCU Institute of Molecular Medicine, Virginia Commonwealth University, Richmond, Virginia 23298 and
    Non-thyroidal illness syndrome (NTIS), characterized by low serum 3,5,3'-triiodothyronine (T3) with normal l-thyroxine (T4) levels, is associated with malignancy. Decreased activity of type I 5'-deiodinase (DIO1), which converts T4 to T3, contributes to NTIS. T3 binds to thyroid hormone receptor, which heterodimerizes with retinoid X receptor (RXR) and regulates transcription of target genes, such as DIO1. Read More

    Endocrine dysfunction in patients of leprosy.
    Indian J Endocrinol Metab 2015 May-Jun;19(3):369-72
    Department of Endocrinology, Command Hospital (WC), Chandimandir, Panchkula, Haryana, India.
    Background: Leprosy is a chronic granulomatous disease and affects many internal organs in addition to the skin and peripheral nerves. Endocrine dysfunction is often silent and is often missed in patients of leprosy leading to significant morbidity. We studied the presence of occult endocrine disorders in leprosy patients and compared the same with disease parameters. Read More

    Endocrine dysfunction in sepsis: a beneficial or deleterious host response?
    Germs 2015 Mar 2;5(1):17-25. Epub 2015 Mar 2.
    MD, PhD, Associate Professor, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania; National Institute for Infectious Diseases "Prof. Dr. Matei Balş", Bucharest, Romania.
    Sepsis is a systemic, deleterious inflammatory host response triggered by an infective agent leading to severe sepsis, septic shock and multi-organ failure. The host response to infection involves a complex, organized and coherent interaction between immune, autonomic, neuroendocrine and behavioral systems. Recent data have confirmed that disturbances of the autonomic nervous and neuroendocrine systems could contribute to sepsis-induced organ dysfunction. Read More

    Thyroid dysfunction in human immunodeficiency virus-infected children and its correlation with CD4(+) T lymphocyte count.
    Indian J Endocrinol Metab 2015 Mar-Apr;19(2):272-6
    Department of Medicine, Regional Institute of Medical Sciences, Imphal, Manipur, India.
    Context: Thyroid dysfunction has been reported in human immunodeficiency virus (HIV)-infected individuals including children. Some studies have reported that thyroid dysfunction may be a marker of severity or progression of HIV.

    Aims: The aim was to study thyroid function in HIV-infected children with and without highly active anti-retroviral therapy (HAART). Read More

    Euthyroid sick syndrome in children with diabetic ketoacidosis.
    Saudi Med J 2015 Feb;36(2):243-7
    Department of Pediatrics, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China. E-mail.
    Objectives: To investigate characteristics of euthyroid sick syndrome (ESS) in children with diabetic ketoacidosis (DKA).

    Methods: This retrospective study was carried out between May 2010 and April 2013 at the Pediatric Department of Shandong Provincial Hospital, Shandong University, Shandong, China. Diabetic ketoacidosis children were divided into 2 groups: euthyroidism (group one, n=30) and ESS (group 2, n=40). Read More

    Isolated vitamin D deficiency is not associated with nonthyroidal illness syndrome, but with thyroid autoimmunity.
    ScientificWorldJournal 2015 12;2015:239815. Epub 2015 Jan 12.
    Department of Endocrinology and Metabolism, Diskapi Training and Research Hospital, 06330 Ankara, Turkey ; Translational Research Center, Diskapi Teaching and Research Hospital, 06330 Ankara, Turkey ; Department of Internal Medicine, School of Medicine (Kastamonu), Hacettepe University, 06330 Ankara, Turkey.
    Aim: This study aimed to compare thyroid functions, thyroid autoantibodies, and the existence of nonthyroidal illness syndrome (NTIS) according to vitamin D level.

    Materials And Methods: The study included age- and BMI-matched healthy volunteers with and without vitamin D deficiency. In addition, the nonthyroidal illness syndrome status was evaluated. Read More

    Assessment of thyroid and gonadal function in liver diseases.
    Indian J Endocrinol Metab 2015 Jan-Feb;19(1):89-94
    Department of Gastroenterology, Army Hospital (R and R), Delhi Cantonment, New Delhi, India.
    Introduction: Liver is involved with the synthesis of carrier proteins and metabolism of various hormones and liver diseases may, therefore, be associated with various endocrine disturbances. This study was conducted to assess thyroid and gonadal function in subjects with acute hepatitis (AH), chronic liver disease (CLD), and those who had undergone liver transplantation (LT).

    Materials And Methods: Patients with AH, CLD with Child-Pugh stage A (CLD-1) and Child-Pugh stage B or C (CLD-2), and LT seen at our tertiary level hospital were assessed clinically, biochemically, and for thyroid and gonadal functions besides 25 healthy controls. Read More

    Nonthyroidal illness syndrome in off-pump coronary artery bypass surger.
    Anatol J Cardiol 2015 Oct 11;15(10):836-42. Epub 2014 Nov 11.
    Department of Nuclear Medicine, University Clinical Center Tuzla, Tuzla-Bosna-Herzeg.
    Objective: It is well known that coronary artery bypass grafting (CABG) is often the cause of non-thyroidal illness syndrome (NTIS). Non-thyroidal illness syndrome (NTIS) is a state characterized by low levels of tri-iodo-thyronine (T3) and high levels of reverse T3 (rT3), with normal or low levels of thyroxin (T4) and normal, low-normal, or low levels of thyroid-stimulating hormone (TSH). Today, there are two main techniques of CABG: CABG with the use of cardiopulmonary bypass (on-pump coronary artery bypass - ONCAB) and CABG without the use of cardiopulmonary bypass (off-pump coronary artery bypass OPCAB), or 'beating-heart surgery. Read More

    Thyroid function in adult Nigerians with metabolic syndrome.
    Pan Afr Med J 2014 29;18:352. Epub 2014 Aug 29.
    Department of Clinical Pathology, Faculty of Clinical Sciences, College of Medicine, University of Lagos, Lagos, Nigeria.
    Introduction: Metabolic syndrome and thyroid dysfunction are two common disorders encountered in the metabolic clinic. Recently, there has been increased interest in the association between the two disorders because of the similarities between symptoms of hypothyroidism and components of the metabolic syndrome. While some reports suggest that metabolic syndrome is associated with subclinical hypothyroidism, this concept is largely under investigated in Nigerian adults with metabolic syndrome. Read More

    Learning to improve medical decision making from imbalanced data without a priori cost.
    BMC Med Inform Decis Mak 2014 Dec 5;14:111. Epub 2014 Dec 5.
    Department of Mathematics, Hong Kong Baptist University, Kowloon Tong, Hong Kong.
    Background: In a medical data set, data are commonly composed of a minority (positive or abnormal) group and a majority (negative or normal) group and the cost of misclassifying a minority sample as a majority sample is highly expensive. This is the so-called imbalanced classification problem. The traditional classification functions can be seriously affected by the skewed class distribution in the data. Read More

    Differential effects of fasting vs food restriction on liver thyroid hormone metabolism in male rats.
    J Endocrinol 2015 Jan 27;224(1):25-35. Epub 2014 Oct 27.
    Department of Endocrinology and Metabolism Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands Hypothalamic Integration Mechanisms Netherlands Institute for Neuroscience, Meibergdreef 47, 1105 BA Amsterdam, The Netherlands Laboratory of Endocrinology Department of Clinical Chemistry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
    A variety of illnesses that leads to profound changes in the hypothalamus-pituitary-thyroid (HPT) are axis collectively known as the nonthyroidal illness syndrome (NTIS). NTIS is characterized by decreased tri-iodothyronine (T3) and thyroxine (T4) and inappropriately low TSH serum concentrations, as well as altered hepatic thyroid hormone (TH) metabolism. Spontaneous caloric restriction often occurs during illness and may contribute to NTIS, but it is currently unknown to what extent. Read More

    Cardiac death risk in diabetic haemodialysis patients increased due to thyroid problems.
    • Authors:
    Cardiovasc J Afr 2014 Jul-Aug;25(4):157
    A prospective study found that diabetic haemodialysis patients' subclinical hyperthyroidism and euthyroid sick syndrome might increase the risk of sudden cardiac-related deaths. Dr Christiane Drechsler, of University Hospital Würzburg in Würzburg, Germany, and colleagues conducted a study that included 1000 patients undergoing haemodialysis for diabetes. Of those patients, 78. Read More

    The role of hypothyroidism in the etiology and progression of dilated cardiomyopathy in Doberman Pinschers.
    J Vet Intern Med 2015 Jan 10;29(1):141-9. Epub 2014 Oct 10.
    Clinic of Small Animal Medicine, University of Munich, Munich, Germany.
    Background: Hypothyroidism and dilated cardiomyopathy (DCM) are both common diseases in Doberman Pinschers. A possible influence of hypothyroidism on the etiology and progression of DCM is controversial.

    Objectives: Evaluation of the role of hypothyroidism in etiology and progression of DCM. Read More

    Systematic review: endocrine abnormalities in patients with liver cirrhosis.
    Arch Iran Med 2014 Oct;17(10):713-21
    1)Department of Internal Medicine, Shiraz University of Medical Science, Shiraz, Iran. 2)Gatroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
    Background: Cirrhosis is the end stage of many different forms of acute and chronic liver damages. Interactions between liver and endocrine system is significant, because liver is the main organ of metabolism and catabolism of many proteins.

    Aim: In this study, current literature about endocrine abnormalities among patients with liver cirrhosis was reviewed. Read More

    Thyroid-like ophthalmopathy in a euthyroid patient receiving Ipilimumab.
    Orbit 2014 Dec 10;33(6):424-7. Epub 2014 Sep 10.
    Department of Ophthalmology, Mater Misericordiae University Hospital , Dublin , Ireland.
    A 68-year-old lady with metastatic malignant melanoma was treated with Ipilimumab. She presented to Eye Casualty unable to move her eyes. Physical examination confirmed ophthalmoplegia and identified proptosis bilaterally. Read More

    [Thyroid dysfunction in adults infected by human immunodeficiency virus].
    Medicina (B Aires) 2014 ;74(4):315-20
    División Endocrinología, Hospital de Clínicas, Universidad de Buenos Aires, Argentina. E-mail:
    Patients infected with human immunodeficiency virus (HIV) have a higher prevalence of thyroid dysfunction when compared with the general population. The most frequently observed manifestations are euthyroid sick syndrome, Graves' disease and subclinical hypothyroidism. The relationship between the use of highly active antiretroviral therapy and the increased prevalence of thyroid dysfunction has been demonstrated in several series of patients. Read More

    Thyroid hormone replacement for nephrotic syndrome patients with euthyroid sick syndrome: a meta-analysis.
    Ren Fail 2014 Oct 26;36(9):1360-5. Epub 2014 Aug 26.
    Medical Center of the Graduate School, Nanchang University , Nanchang , P.R. China and.
    Objective: To assess the efficacy of thyroid hormone replacement therapy for nephrotic syndrome (NS) patients associated with euthyroid sick syndrome (ESS).

    Materials And Methods: The Cochrane library, ISI, Ovid, PubMed, Chinese Biomedicine Database were searched, and reference list of relevant articles were selected. Randomized controlled trials (RCTs) or quasi-RCTs with thyroid hormone replacement on NS patients associated with ESS were included in this analysis. Read More

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