768 results match your criteria Euthyroid Sick Syndrome


Insights from a Prospective Follow-up of Thyroid Function and Autoimmunity among COVID-19 Survivors.

Endocrinol Metab (Seoul) 2021 Jun 8. Epub 2021 Jun 8.

Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China.

Background: The occurrence of Graves' disease and Hashimoto thyroiditis after coronavirus disease 2019 (COVID-19) raised concerns that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may trigger thyroid autoimmunity. We aimed to address the current uncertainties regarding incident thyroid dysfunction and autoimmunity among COVID-19 survivors.

Methods: We included consecutive adult COVID-19 patients without known thyroid disorders, who were admitted to Queen Mary Hospital from July 21 to September 21, 2020 and had serum levels of thyroid-stimulating hormone, free thyroxine, free triiodothyronine (fT3), and anti-thyroid antibodies measured both on admission and at 3 months. Read More

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Thyroid dysfunction in COVID-19 patients.

J Endocrinol Invest 2021 Jun 8. Epub 2021 Jun 8.

Endocrinology Unit, Department of Oncology and Medical Specialities, A.O. San Camillo Forlanini, Rome, Italy.

Purpose: "Non thyroidal illness syndrome" (NTIS) or "euthyroid sick syndrome" (ESS) is a possible biochemical finding in euthyroid patients with severe diseases. It is characterized by a reduction of serum T (fT3), sometimes followed by reduction of serum T (fT4). The relationship between thyroid hormones levels and mortality is well known and different studies showed a direct association between NTIS and mortality. Read More

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Prognostic significance of low TSH concentration in patients with COVID-19 presenting with non-thyroidal illness syndrome.

BMC Endocr Disord 2021 May 27;21(1):111. Epub 2021 May 27.

Institute of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Background: Low free triiodothyronine (FT3) levels are related to a poor prognosis deterioration in patients with COVID-19 presenting with non-thyroidal illness syndrome (NTI). This study was designed to explore whether free thyroxin (FT4) or thyroid stimulating hormone (TSH) levels affected the mortality of patients with COVID-19 presenting with NTI.

Methods: Patients with COVID-19 complicated with NTI who were treated at our hospital were included in this retrospective study. Read More

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Association between Thyroid Function and Prognosis of COVID-19: A Retrospective Observational Study.

Endocr Res 2021 May 20:1-8. Epub 2021 May 20.

Department of Endocrinology and Metabolism, Peking University Third Hospital, Beijing, China.

: Coronavirus disease 2019 (COVID-19) is a severe infectious illness. It has been reported that COVID-19 has an effect on thyroid function. However, the association between thyroid function and prognosis of COVID-19 is still unclear. Read More

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Role of non-thyroidal illness syndrome in predicting adverse outcomes in COVID-19 patients predominantly of mild-to-moderate severity.

Clin Endocrinol (Oxf) 2021 Apr 4. Epub 2021 Apr 4.

Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China.

Objective: Existing studies reported the potential prognostic role of non-thyroidal illness syndrome (NTIS), characterized by low triiodothyronine (T3) with normal/low thyroid-stimulating hormone (TSH), mainly in severe COVID-19. None considered the significant impact of SARS-CoV-2 viral load on adverse outcomes. We aimed to clarify the prognostic role of NTIS among predominantly mild-to-moderate COVID-19 patients. Read More

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Gene signature and immune cell profiling by high-dimensional, single-cell analysis in COVID-19 patients, presenting Low T3 syndrome and coexistent hematological malignancies.

J Transl Med 2021 04 1;19(1):139. Epub 2021 Apr 1.

Department of Clinical and Molecular Medicine, Sapienza University, Via di Grottarossa, 1035/1039, 00189, Rome, Italy.

Background: Low T3 syndrome is frequent in patients admitted to intensive care units for critical illness and pneumonia. It has been reported also in patients with COVID-19, Hodgkin disease and chronic lymphocytic leukemia. We analyzed the clinical relevance of Low T3 syndrome in COVID-19 patients and, in particular, in those with associated hematological malignancies. Read More

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Commentary: Euthyroid Sick Syndrome in Patients With COVID-19.

Front Endocrinol (Lausanne) 2021 10;12:633097. Epub 2021 Feb 10.

Department of Neuroscience, Psychology, Drug Sciences, and Child Health (NEUROFARBA), University of Florence, Florence, Italy.

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Thyroid Function Abnormalities in COVID-19 Patients.

Front Endocrinol (Lausanne) 2020 19;11:623792. Epub 2021 Feb 19.

Department of Surgical Oncology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Purpose: The novel coronavirus COVID-19, has caused a worldwide pandemic, impairing several human organs and systems. Whether COVID-19 affects human thyroid function remains unknown.

Methods: Eighty-four hospitalized COVID-19 patients in the First Affiliated Hospital, Zhejiang University School of Medicine (Hangzhou, China) were retrospectively enrolled in this study, among which 22 cases had complete records of thyroid hormones. Read More

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COVID-19-related thyroiditis: A novel disease entity?

Clin Endocrinol (Oxf) 2021 Mar 2. Epub 2021 Mar 2.

Centre for Endocrinology, Barts, London School of Medicine, Queen Mary University of London, London, UK.

The literature on COVID-19-related thyroid complications has accumulated over the past year or so as the pandemic has accelerated throughout the world. In particular, several recent case reports have been published describing a possible correlation between COVID-19 disease and subacute thyroiditis (SAT). In this review, we briefly present one of our own patients and review the current published literature in this area up to January 2021, including analyses of major series of thyroid function tests in patients with significant COVID-19 infection. Read More

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Thyroid Function Test in COVID-19 Patients: A Cross-Sectional Study in a Tertiary Care Hospital.

Indian J Endocrinol Metab 2020 Nov-Dec;24(6):532-536. Epub 2021 Jan 12.

Department of Fertility Studies, International Institute for Population Sciences, Mumbai, Maharastra, India.

Context: There is scarcity of data on thyroid function abnormality in COVID-19 patients in world literature.

Aims: The objective of this study was to assess thyroid function tests in hospitalized patients of COVID-19.

Settings And Design: Sixty (60) patients with COVID-19 detected by RT-PCR admitted in General Medicine isolation ward and COVID block of a tertiary care teaching hospital were selected by semi-purposive sampling. Read More

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January 2021

Thyroid Dysfunction in Patients Admitted in Cardiac Care Unit: Prevalence, Characteristic and Hospitalization Outcomes.

Int J Gen Med 2021 18;14:505-514. Epub 2021 Feb 18.

Department of Medicine, College of Medicine, Taif University, Taif, 21944, Saudi Arabia.

Introduction: Cardiovascular disease is one of the main causes of hospital admission and mortality, and thyroid dysfunction increases the risk of developing acute or exacerbation of chronic cardiac conditions. The aim of this study is to investigate the prevalence of thyroid hormone abnormality among patients in the cardiac care unit (CCU) patients and its relation to admission diagnosis, clinical, biochemical data, and hospital-related outcomes.

Methods: We conducted a retrospective cohort observational that included adult patients who were admitted to the CCU. Read More

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February 2021

Sick Euthyroid Syndrome on Presentation of Patients With COVID-19: A Potential Marker for Disease Severity.

Endocr Pract 2021 Feb 11;27(2):101-109. Epub 2021 Jan 11.

Dalia and David Arabov Endocrinology and Diabetes Research Center, Institute of Endocrinology, Sheba Medical Center, Tel Hashomer, Israel; Sackler Faculty of Medicine, Tel Aviv University, Israel.

Objective: Precise risk stratification and triage of coronavirus disease 2019 (COVID-19) patients are essential in the setting of an overwhelming pandemic burden. Clinical observation has shown a somewhat high prevalence of sick euthyroid syndrome among patients with COVID-19. This study aimed to evaluate the predictive value of free triiodothyronine (FT3) at the clinical presentation of COVID-19 for disease severity and death. Read More

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February 2021

Incidence of low-triiodothyronine syndrome in patients with septic shock.

Rev Bras Ter Intensiva 2020 Oct-Dec;32(4):514-520

Unidad de Terapia Intensiva, Centro de Medicina Integral del Comahue - Neuquén, Argentina.

Objective: Low levels of thyroid hormones have been associated with poor clinical outcomes. This metabolic situation, designated euthyroid sick syndrome, has been interpreted as a state of adaptation to different pathological processes, characterized by the decrease in plasma triiodothyronine. The present study seeks to determine the incidence of this disorder in patients with septic shock and its relationship with other severity indices and clinical outcomes. Read More

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November 2019

An update on non-thyroidal illness syndrome.

Authors:
E Fliers A Boelen

J Endocrinol Invest 2020 Dec 15. Epub 2020 Dec 15.

Endocrine Laboratory, Department of Clinical Chemistry, Amsterdam Gastroenterology Endocrinology and Metabolism, Amsterdam UMC, University of Amsterdam, 1105 AZ, Amsterdam, The Netherlands.

The non-thyroidal illness syndrome (NTIS) was first reported in the 1970s as a remarkable ensemble of changes in serum TH (TH) concentrations occurring in probably any severe illness. Ever since, NTIS has remained an intriguing phenomenon not only because of the robustness of the decrease in serum triiodothyronine (T3), but also by its clear correlation with morbidity and mortality. In recent years, it has become clear that (parenteral) feeding in patients with critical illness should be taken into account as a major determinant not only of NTIS but also of clinical outcome. Read More

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December 2020

Thyroid dysfunction may be associated with poor outcomes in patients with COVID-19.

Mol Cell Endocrinol 2021 02 2;521:111097. Epub 2020 Dec 2.

Department of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China. Electronic address:

Background: Coronavirus disease (COVID-19) has resulted in considerable morbidity and mortality worldwide. Thyroid hormones play a key role in modulating metabolism and the immune system. However, the prevalence of thyroid dysfunction (TD) and its association with the prognosis of COVID-19 have not yet been elucidated. Read More

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February 2021

[Association of non-thyroidal illness syndrome with interleukin-6 and interleukin-10 in critically ill children with sepsis].

Zhongguo Dang Dai Er Ke Za Zhi 2020 Nov;22(11):1215-1220

Pediatric Intensive Care Unit, Hebei Children's Hospital, Shijiazhuang 050000, China.

Objective: To study the incidence rate of non-thyroidal illness syndrome (NTIS) in critically ill children with or without sepsis and the association of NTIS with interleukin-6 (IL-6) and interleukin-10 (IL-10).

Methods: A retrospective analysis was performed on the medical data of 97 children with sepsis (sepsis group) and 80 non-sepsis children with bacterial infection (non-sepsis group). The correlations of IL-6 and IL-10 with the thyroid function parameters triiodothyronine (T3), thyroxine (T4), and thyroid stimulating hormone (TSH) were analyzed. Read More

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November 2020

The effect of oral triiodothyronine supplementation on lactate and pyruvate after paediatric cardiac surgery.

Cardiol Young 2021 Feb 10;31(2):205-211. Epub 2020 Nov 10.

Department of Pediatrics, University of Washington School of Medicine and Division of Cardiology, Seattle Children's Hospital, Seattle, WA, USA.

Objective: To determine if triiodothyronine alters lactate, glucose, and pyruvate metabolism, and if serum pyruvate concentration could serve as a predictor of low cardiac output syndrome in children after cardiopulmonary bypass procedures.

Methods: This study was ancillary to the Oral Triiodothyronine for Infants and Children undergoing Cardiopulmonary bypass (OTICC) trial. Serum pyruvate was measured in the first 48 patients and lactate and glucose were measured in all 208 patients enrolled in the OTICC study on the induction of anaesthesia, 1 and 24 hours post-aortic cross-clamp removal. Read More

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February 2021

Thyroid Dysfunction in Relation to Immune Profile, Disease Status, and Outcome in 191 Patients with COVID-19.

J Clin Endocrinol Metab 2021 01;106(2):e926-e935

Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China.

Objective: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-related thyroiditis is increasingly recognized. The role of thyroid autoimmunity and SARS-CoV-2 viral load in SARS-CoV-2-related thyroid dysfunction is unclear. We evaluated the thyroid function of a cohort of coronavirus disease 2019 (COVID-19) patients, in relation to their clinical features, and biochemical, immunological, and inflammatory markers. Read More

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January 2021

Euthyroid Sick Syndrome in Patients With COVID-19.

Front Endocrinol (Lausanne) 2020 7;11:566439. Epub 2020 Oct 7.

Critical Care Medicine, The Second Xiangya Hospital, Central South University, Changsha, China.

Background: Coronavirus disease 2019 (COVID-19) has been shown to affect almost every organ throughout the body. However, it is not clear whether the thyroid gland is impaired in COVID-19 patients. Euthyroid sick syndrome (ESS) is usually associated with the disease severity and deterioration prognosis in critical illness. Read More

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November 2020

Clinical and laboratory aspects of 3,3',5'-triiodothyronine (reverse T3).

Ann Clin Biochem 2021 01 4;58(1):29-37. Epub 2020 Nov 4.

Blood Sciences, Cambridge University Hospitals NHS Foundation Trust, Addenbrooke's Hospital, Cambridge, UK.

Reverse T3 (3,3',5'-triiodothyronine or rT3) is the third most abundant iodothyronine circulating in human blood and is produced by the inner ring deiodination of the pro-hormone thyroxine (T4). Unlike the more abundant and active metabolite T3, the measurement of serum rT3 is yet to find a routine clinical application. As rT3 binds weakly to the T3 thyroid nuclear hormone receptors, it is thought to represent an inactive end-product of thyroid hormone metabolism, diverting T4 away from T3 production. Read More

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January 2021

Serum thyroxine and thyrotropin concentrations decrease with severity of nonthyroidal illness in cats and predict 30-day survival outcome.

J Vet Intern Med 2020 Nov 1;34(6):2276-2286. Epub 2020 Oct 1.

College of Veterinary Medicine, Cornell University, Ithaca, New York, USA.

Background: In cats, nonthyroidal illness affects serum thyroid hormone concentrations. Serum thyroxine (T ) and triiodothyronine (T ) concentrations commonly decrease, whereas free T (fT ) concentrations vary unpredictably. Limited information exists regarding effects on serum thyrotropin (thyroid-stimulating hormone [TSH]) concentrations in cats with nonthyroidal illness syndrome (NTIS). Read More

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November 2020

Hypothyroidism and its Association with Systemic Lupus Erythematosus: A Cross Sectional Study in Chinese Patients.

Am J Med Sci 2021 01 22;361(1):63-68. Epub 2020 Aug 22.

Department of General Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, China. Electronic address:

Background: Specific factors correlated with hypothyroidism in systemic lupus erythematosus (SLE) patients remain unclear. Therefore, we aim to evaluate the prevalence of thyroid dysfunction in Chinese patients with SLE and the relationship between clinical hypothyroidism and SLE.

Methods: We conducted a cross sectional study of the prevalence of thyroid dysfunction in 672 patients with SLE and 605 age- and sex-matched healthy controls. Read More

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January 2021

Severe hyperthyroidism without symptoms due to nonthyroidal illness in a child with acute hepatitis: case report and literature review.

Ann N Y Acad Sci 2021 03 23;1487(1):5-11. Epub 2020 Sep 23.

Division of Pediatric Endocrinology, Rutgers-Robert Wood Johnson Medical School, New Brunswick, New Jersey.

While liver enzyme changes are frequently reported in hyperthyroidism, liver dysfunction itself can lead to alterations in thyroid hormone metabolism. However, the exact relationship between hyperthyroidism and liver dysfunction is unclear. We report an 11-year-old boy presenting with acute hepatitis of unknown etiology, who was incidentally found to have asymptomatic biochemical hyperthyroidism. Read More

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Determinants of deranged thyroid function parameters in children admitted for management of diabetic ketoacidosis/diabetic ketosis.

BMC Endocr Disord 2020 Sep 1;20(1):135. Epub 2020 Sep 1.

Department of Pediatrics, Liaocheng People's Hospital, Liaocheng, 252000, Shandong, China.

Background: Euthyroid sick syndrome (ESS) frequently arises in children admitted with diabetic ketoacidosis/diabetic ketosis (DKA/DK). This study evaluates the interplay of various metabolic factors with occurrence of deranged thyroid function tests in children suffering from DKA/DK.

Methods: 98 DKA and 96 DK pediatric patients were selected from hospital records. Read More

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September 2020

Prognostic Value of Thyroid Hormone FT3 in General Patients Admitted to the Intensive Care Unit.

Biomed Res Int 2020 12;2020:6329548. Epub 2020 Jul 12.

Department of Endocrinology, The Third Hospital of Hebei Medical University, Shijiazhuang 050051, China.

Low plasma triiodothyronine (T3) concentration indicates nonthyroidal illness syndrome (NTIS), which might be associated with a poor outcome in patients in the intensive care unit (ICU). This study evaluated the relationship between NTIS and prognostic indicators in patients admitted to the ICU and examined the fT3 cut-off points that could be associated with 28-day mortality. This prospective observational study included patients admitted to the ICU of The Third Hospital of Hebei Medical University from February to November 2018. Read More

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The effect of beta-blockers on a course of chronic heart failure in patients with a low triiodothyronine syndrome.

Wiad Lek 2020 ;73(7):1402-1409

Government Institution "L.T.Malaya Therapy National Institute Of The National Academy Of Medical Sciences Of Ukraine", Kharkiv, Ukraine.

Objective: The aim: The aim is to study the effect of β-ABs in patients with LT3 S on the course of HF.

Patients And Methods: Materials and methods: 354 patients with HF on a background of post-infarction cardiosclerosis were included in the 2-yeared follow-up study. LT3 S was diagnosed at 89 (25. Read More

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Low Yield of Thyroid-Function Tests in Adult Hospitalized Patients - A Retrospective Analysis.

Int J Gen Med 2020 6;13:343-349. Epub 2020 Jul 6.

Division of Endocrinology and Molecular Medicine, Department of Internal Medicine, University of Kentucky, Lexington, KY, USA.

Background: In the US, serum thyroid-stimulating hormone (TSH) and thyroxine measurements are the fourth- and tenth-commonest laboratory tests ordered, respectively. Diagnosis of thyroid disorder requires clinical suspicion supported by laboratory values. However, in the setting of acute illness, both the clinical and laboratory pictures can be confounded. Read More

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Thyroid dysfunctions in adult patients after allogeneic hematopoietic stem cell transplantation.

Clin Transplant 2020 10 29;34(10):e14049. Epub 2020 Aug 29.

Department of Hematology, Ankara University School of Medicine, Ankara, Turkey.

Introduction: Thyroid dysfunction (TD) is one of the major endocrinopathies shown after allogeneic hematopoietic stem cell transplantation over the long term. The incidence and the risk factors for TD have varied widely.

Patients And Methods: Two hundred and fifty-nine patients with pre-transplant normal thyroid function tests who survived at least 1 year after allo-HSCT between 2006-2016 were included in the study. Read More

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October 2020

Euthyroid sick syndrome in hip fractures: Evaluation of postoperative anemia.

Injury 2020 Aug 3;51 Suppl 3:S9-S12. Epub 2020 Jul 3.

Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma - Università Cattolica del Sacro Cuore.

Introduction: Incidence of hip fractures is increasing with upward estimates representing one of the most current health problems. According to some authors this condition is associated with an early mortality rate ranging between 20% and 35% and low outcomes. One of the predictive factors of poor outcome after hip fracture is anaemia. Read More

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