724 results match your criteria Euthyroid Sick Syndrome


Euthyroid sick syndrome in paediatric and adult patients requiring extracorporeal circulatory support and the role of thyroid hormone supplementation: a review.

Perfusion 2020 May 19:267659120914136. Epub 2020 May 19.

Department of Anesthesiology, Complejo Hospitalario Universitario de Santiago de Compostela, Santiago de Compostela, Spain.

Non-thyroid disorders may modify thyroid hormone metabolism, resulting in an 'euthyroid sick syndrome'. Studies determining the association of cardiopulmonary bypass to thyroid function showed changes in line with this euthyroid sick syndrome. In some cases, cardiovascular dysfunction after cardiac surgery with cardiopulmonary bypass is comparable to that noticed in hypothyroidism associated with low cardiac output and elevated systemic vascular resistance. Read More

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http://dx.doi.org/10.1177/0267659120914136DOI Listing

Therapy with L-thyroxine and Omnadren after Cardiac Surgery. A Case Report.

Folia Med (Plovdiv) 2019 12;61(4):650-654

St Anna University Hospital, Sofia, Bulgaria.

Background: Cardiopulmonary bypass in cardiac surgery produces systemic inflammatory response and catabolic state. Severe stress frequently causes abnormalities in thyroid hormones in the absence of primary thyroid disease, defined as sick euthyroid syndrome (SES).

Materials And Methods: Supplementation therapy with thyroid and anabolic hormones in combination with an adequate nutritional support has been used to improve outcome in critically ill patient after cardiac surgery. Read More

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http://dx.doi.org/10.3897/folmed.61.e47962DOI Listing
December 2019

Novel Gene Mutation in a Case of Abetalipoproteinemia with Central Hypothyroidism

Authors:
Sezer Acar

J Clin Res Pediatr Endocrinol 2020 Jun 11;12(2):223-224. Epub 2020 Mar 11.

Dr. Behçet Uz Children’s Hospital, Clinic of Pediatric Endocrinology, İzmir, Turkey

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http://dx.doi.org/10.4274/jcrpe.galenos.2020.2020.0015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291409PMC

Euthyroid sick syndrome in hip fractures: Valuation of vitamin D and parathyroid hormone axis.

Injury 2020 Jan 9. Epub 2020 Jan 9.

Fondazione Policlinico Universitario A. Gemelli IRCSS, Roma, Italia; Università Cattolica Del Sacro Cuore, Roma, Italia.

Introduction: Femur fracture is an acute event with a high incidence and mortality worldwide. Euthyroid sick syndrome (ESS) is a disease characterized by an alteration of fT3 in the absence of a primary thyroid pathology. The aim of the study is evaluating the association between femur fracture and ESS and post-operative fluctuations of the parathyroid hormone (PTH) and vitamin D and their physio-pathological implications. Read More

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http://dx.doi.org/10.1016/j.injury.2020.01.013DOI Listing
January 2020

The association of polymorphisms of β-adrenergic receptors genes with the low triiodothyronine syndrome in patients with a heart failure.

Pol Merkur Lekarski 2019 Nov;47(281):170-176

Government Institution L.T. Malaya Therapy National Institute of the National Academy of Medical Sciences of Ukraine, Kharkiv, Ukraine.

The course of heart failure (HF) and its progression is associated with comorbidities, genetic factors and a dynamics of a number of biomarkers. The low triiodothyronine syndrome (LT3S) is observed in some patients with HF. Extremely little data are available in the literature regarding the effect of β-adrenoreceptors (β-AR) genes polymorphisms on the development of LT3S and many contradictory results about their association with HF course. Read More

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November 2019

Congestive Heart Failure and Thyroid Dysfunction: The Role of the Low T3 Syndrome and Therapeutic Aspects.

Endocr Metab Immune Disord Drug Targets 2020 ;20(5):646-653

Interdisciplinary Department of Medicine, University of Bari, Bari, Italy.

Background: Both the morbidity and mortality rates from congestive heart failure (CHF) remain elevated despite the medical and non-medical management of the disease, thus suggesting the existence of residual risk factors such as thyroid dysfunction. Particularly, the 15-30% of patients with CHF, especially those with severe ventricular dysfunction, display the so-called low T3 syndrome (LT3S), which seems to negatively affect the cardiovascular prognosis.

Objective: Only a few clinical trials have been carried out to verify both the safety and the efficacy of thyroid replacement in the LT3S, aiming to ameliorate the prognosis of CHF, and most of the results were controversial. Read More

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http://dx.doi.org/10.2174/1871530319666191119112950DOI Listing
January 2020

Correlation analysis of serum thyroid stimulating hormone with acute cerebrovascular disease.

Eur J Med Res 2019 Oct 24;24(1):35. Epub 2019 Oct 24.

Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, Tongji University School of Medicine, No. 301, Middle Yan Chang Road, Shanghai, 200072, China.

Background: Acute cerebrovascular disease (ACVD) could cause abnormal metabolism of thyroid hormones (TH), mostly represented as a euthyroid sick syndrome or low T3 syndrome. However, the changes in serum thyroid-stimulating hormone (TSH) are controversial. The aim of this study is to investigate the clinical significance of TSH alteration in patients with ACVD. Read More

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http://dx.doi.org/10.1186/s40001-019-0395-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6813055PMC
October 2019
1 Read

Commentary on: "A prognostic role for non-thyroidal illness syndrome in chronic renal failure: A systematic review and meta-analysis".

Int J Surg 2019 11 21;71:100. Epub 2019 Sep 21.

Jinnah Postgraduate Medical Centre, Pakistan. Electronic address:

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http://dx.doi.org/10.1016/j.ijsu.2019.09.021DOI Listing
November 2019
2 Reads

Congenital Heart Disease and Thyroid Dysfunction: Combination, Association, and Implication.

World J Pediatr Congenit Heart Surg 2019 09;10(5):604-615

Pediatric Cardiac Critical Care Unit, Hadassah University Medical Center, Ein Kerem, Jerusalem, Israel.

Background: Patients with congenital heart disease have higher prevalence of thyroid dysfunction due to embryonic and genetic coexistence. Marked changes in cardiac function occur secondary to alternations in thyroid hormone levels. Cardiac catheterizations or cardiac surgeries with cardiopulmonary bypass can cause abnormalities in the circulating hormones, in the absence of primary thyroid disease. Read More

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http://dx.doi.org/10.1177/2150135119857704DOI Listing
September 2019
1 Read

Evaluation of Thyroid Function Tests in Children with Chronic Liver Diseases

J Clin Res Pediatr Endocrinol 2020 06 5;12(2):143-149. Epub 2019 Sep 5.

Dokuz Eylül University Faculty of Medicine, Division of Pediatric Endocrinology, İzmir, Turkey

Objective: Studies examining changes in thyroid function in the course of chronic liver disease have mostly been conducted in adults. The aim of this study was to investigate thyroid dysfunction in children with chronic liver diseases.

Methods: Between 2005 and 2018, patients aged up to 18 years of age, diagnosed with chronic liver disease and had thyroid function test results available were included. Read More

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http://dx.doi.org/10.4274/jcrpe.galenos.2019.2019.0029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291396PMC
June 2020
2 Reads

Low triiodothyronine syndrome and serum selenium status in the course of acute myocardial infarction.

Pol Merkur Lekarski 2019 Aug;47(278):45-51

Jagiellonian University Medical College, Department of Coronary Disease and Heart Failure, Krakow, Poland; John Paul II Hospital, Department of Coronary Disease and Heart Failure, Krakow, Poland.

Both glutathione peroxidase and deiodinases are selenoproteins requiring selenium. Oxidative stress accompanying acute myocardial infarction (MI) may lead to activation of peroxidase and relative selenium deficiency. That may impair conversion of tetraiodothyronine (T4) to triiodothyronine (T3). Read More

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Prevalence and Pattern of Thyroid Disorders among Patients Attending University of Nigeria Teaching Hospital, Enugu, Southeastern Nigeria.

Niger Med J 2019 Mar-Apr;60(2):62-67

Department of Chemical Pathology, University of Nigeria Teaching Hospital, Enugu, Nigeria.

Introduction: Thyroid disorders (TDs) remain the second-most common endocrine disease after diabetes worldwide. Recently, there has been increased interest in the prevalence and pattern of TD based on the fact that it accelerates cardiovascular complications. However, there are limited data on the prevalence and pattern of TDs in the University of Nigeria Teaching Hospital (UNTH) Enugu, Southeast Nigeria. Read More

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http://dx.doi.org/10.4103/nmj.NMJ_34_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6688398PMC
August 2019
1 Read

A prognostic role for non-thyroidal illness syndrome in chronic renal failure:a systematic review and meta-analysis.

Int J Surg 2019 Oct 19;70:44-52. Epub 2019 Aug 19.

Department of Intensive Care Unit, The First Hospital of Lanzhou University, Lanzhou, 730000, China; The First Clinical Medical College of the First Hospital of Lanzhou University, Lanzhou, 730000, China. Electronic address:

Background: Chronic renal failure (CRF) is a serious disease that has become a burden on global and local economics and public health. In addition, non-thyroidal illness syndrome (NTIS) has become increasingly more prevalent in CRF patients.

Materials And Methods: A data search was conducted on the PubMed/Medline, Cochrane Library, Web of Science, Embase, and CBM databases to identify studies up to November 1st, 2018, that compared low T3 and normal T3 levels in patients with CRF. Read More

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http://dx.doi.org/10.1016/j.ijsu.2019.08.019DOI Listing
October 2019
1 Read

Persistent anemia and hypoalbuminemia in rheumatoid arthritis patients with low serum triiodothyronine level.

Mod Rheumatol 2019 Aug 8:1-8. Epub 2019 Aug 8.

a Department of Rheumatology and Clinical Immunology , Kyoto University Graduate School of Medicine , Kyoto , Japan.

To determine the clinical characteristics of rheumatoid arthritis (RA) patients with low serum triiodothyronine (T3) levels. We evaluated serum free T3 (fT3), free T4, and thyroid-stimulating hormone (TSH) levels in 338 RA patients. After excluding patients taking anti-thyroid drugs or having anti-thyroid antibodies, we compared the clinical characteristics of the RA patients with low fT3 to those with normal/high fT3, before and after RA treatment. Read More

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https://www.tandfonline.com/doi/full/10.1080/14397595.2019.1
Publisher Site
http://dx.doi.org/10.1080/14397595.2019.1649109DOI Listing
August 2019
5 Reads

Comments: "Low triiodothyronine syndrome is associated with platelet function in patients with nephrotic syndrome".

Rev Assoc Med Bras (1992) 2019 08 5;65(7):993-994. Epub 2019 Aug 5.

Harvard Medical School, Department of Neurosurgery, Brigham and Women's Hospital, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1590/1806-9282.65.7.993DOI Listing
August 2019
2 Reads

Low triiodothyronine syndrome is associated with platelet function in patients with nephrotic syndrome.

Rev Assoc Med Bras (1992) 2019 Aug 5;65(7):988-992. Epub 2019 Aug 5.

Department of Nephrology, The First Affiliated Hospital of Nanjing Medical University (Jiangsu Province Hospital), Jiangsu, China.

Objective: The objective of this study was to investigate the effects of low triiodothyronine syndrome (LT3S) on platelet function and clotting factors in patients with nephrotic syndrome(NS).

Methods: Patients with primary nephrotic syndrome were divided into two groups, normal thyroid function (group A) and LT3S (group B), based on whether they had LT3S or not. Healthy subjects were selected as the control group (group C). Read More

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http://dx.doi.org/10.1590/1806-9282.65.7.988DOI Listing
August 2019
3 Reads

Nonthyroidal illness in critically ill children.

Curr Opin Endocrinol Diabetes Obes 2019 10;26(5):241-249

Clinical Division and Laboratory of Intensive Care Medicine, Department of Cellular and Molecular Medicine, KU Leuven University Hospital, Leuven, Belgium.

Purpose Of Review: This review summarizes recent literature on nonthyroidal illness syndrome (NTI) and outcome of pediatric critical illness, to provide insight in pathophysiology and therapeutic implications.

Recent Findings: NTI is typically characterized by lowered triiodothyronine levels without compensatory TSH rise. Although NTI severity is associated with poor outcome of pediatric critical illness, it remains unclear whether this association reflects an adaptive protective response or contributes to poor outcome. Read More

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http://dx.doi.org/10.1097/MED.0000000000000494DOI Listing
October 2019
1 Read

Oral Triiodothyronine Supplementation Decreases Low Cardiac Output Syndrome After Pediatric Cardiac Surgery.

Pediatr Cardiol 2019 Aug 15;40(6):1238-1246. Epub 2019 Jul 15.

Department of Pediatric Cardiology and Pediatric Intensive Care, Medical Hospital of the University of Munich, Munich, Germany.

The oral triiodothyronine for infants and children undergoing cardiopulmonary bypass (OTICC) trial showed that Triiodothyronine (T3) supplementation improved hemodynamic and clinical outcome parameters. We tested the validity of low cardiac output syndrome (LCOS), derived using clinical parameters and laboratory data, by comparing the LCOS diagnosis with objective parameters commonly measured in a cardiac intensive care unit (CCU) setting. OTICC, a randomized, placebo-controlled trial included children younger than 3 years with an Aristotle score between 6 and 9. Read More

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http://dx.doi.org/10.1007/s00246-019-02143-xDOI Listing
August 2019
4 Reads

[Impact of low T3 syndrome on adverse cardiovascular events in adult patients with acute viral myocarditis].

Zhonghua Xin Xue Guan Bing Za Zhi 2019 Jun;47(6):447-451

Department of Cardiology, Fuwai Hospital, Chinese Academy of Medical Sciences, National Center for Cardiovascular Diseases, Beijing 100037, China.

To determine the impact of low T3 syndrome on adverse cardiovascular events in adult patients with acute viral myocarditis. The study population consisted of 134 consecutive patients admitted between January 2002 and March 2018 with diagnoses of acute viral myocarditis (onset of symptoms<1 month,patients were divided into low serum free triiodothyronine (FT3, 20) group and normal FT3 (114) group. General information, clinical presentation,electrocardiography at admission,laboratory tests,echocardiography features were analyzed. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0253-3758.2019.06.005DOI Listing
June 2019
7 Reads

THE ASSOCIATION OF LOW TRIIODOTHYRONINE SYNDROME, PROTEIN-ENERGY WASTING AND CHRONIC INFLAMMATION WITH MORTALITY IN PREVALENT DIALYSIS PATIENTS.

Acta Clin Croat 2018 Sep;57(3):449-457

1Division of Nephrology and Dialysis, Department of Internal Medicine, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia; 2Division of Hematology, Department of Internal Medicine, Dubrava University Hospital, Zagreb, Croatia; 3Division of Nephrology and Dialysis, Department of Internal Medicine, Dr Tomislav Bardek General Hospital, Koprivnica, Croatia.

- This prospective study in prevalent dialysis patients investigated prognostic properties of low triiodothyronine syndrome, protein-energy wasting and chronic inflammation. Ninety-four prevalent dialysis patients were followed-up for a median of 39 months. Demographic, anthropometric and biochemical parameters were collected at baseline. Read More

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http://dx.doi.org/10.20471/acc.2018.57.03.07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6536271PMC
September 2018
7 Reads

Thyroid Hormone (Triiodothyronine) Therapy in Children After Congenital Heart Surgery: A Meta-Analysis.

Semin Thorac Cardiovasc Surg 2020 22;32(1):87-95. Epub 2019 May 22.

Section of Critical Care and Cardiology, Department of Pediatrics, Texas Children's Hospital, Baylor College of Medicine, Houston, Texas.

Thyroid hormone modifies metabolic, immune and cardiovascular functions and has been administered perioperatively to treat a relative reduction of thyroid function in children following cardiopulmonary bypass (CPB) for correction of congenital heart disease. However, it remains unclear whether its use is associated with improved outcomes. We performed a meta-analysis of studies that evaluated the impact of thyroid hormone supplementation on clinical outcomes in children undergoing repair of congenital heart disease using CPB. Read More

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http://dx.doi.org/10.1053/j.semtcvs.2019.05.020DOI Listing
June 2020
9 Reads

Predictors for euthyroid sick syndrome and its impact on in-hospital clinical outcomes in high-risk patients undergoing coronary artery bypass grafting.

Perfusion 2019 11 10;34(8):679-688. Epub 2019 May 10.

Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.

Objective: The purpose of this cohort study was to investigate the independent relationship between euthyroid sick syndrome and in-hospital outcomes in high-risk patients undergoing isolated coronary artery bypass grafting, and we also examined the direct correlation between pre- or intra-operative variables and the incidence of coronary artery bypass grafting-associated euthyroid sick syndrome.

Methods: The present study enrolled high-risk patients undergoing coronary artery bypass grafting from 1 January 2017 to 31 December 2017 in Beijing Anzhen hospital, including 387 (58.7%) patients with coronary artery bypass grafting-associated euthyroid sick syndrome and 272 (41. Read More

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http://journals.sagepub.com/doi/10.1177/0267659119846789
Publisher Site
http://dx.doi.org/10.1177/0267659119846789DOI Listing
November 2019
18 Reads

Low triiodothyronine syndrome and selenium deficiency - undervalued players in advanced heart failure? A single center pilot study.

BMC Cardiovasc Disord 2019 05 7;19(1):105. Epub 2019 May 7.

Department of Coronary Disease and Heart Failure, Jagiellonian University Medical College, Krakow, Poland.

Background: The function of deiodinases - selenoproteins converting thyroid hormones may be disturbed by oxidative stress accompanying heart failure. Selenium (Se) may be used by glutathione peroxidase, leading to a lack of deiodinase and triiodothyronine (T3). The aim of the study was the evaluation of the prevalence and clinical significance of low T3 syndrome in heart failure and the assessment of the association of low fT3 and Se deficiency. Read More

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http://dx.doi.org/10.1186/s12872-019-1076-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6505272PMC
May 2019
9 Reads

Thyroid Hormone Profile in Children with Sepsis: Does Euthyroid Sick Syndrome Exist?

Open Access Maced J Med Sci 2019 Apr 14;7(7):1110-1113. Epub 2019 Apr 14.

Department of Child Health, Faculty of Medicine, Universitas Sumatera Utara, Haji Adam Malik General Hospital, Medan, Indonesia.

Background: Alterations in peripheral thyroid hormone metabolism play an eminent role in the development of the euthyroid sick syndrome. Altered solvation may also lead to changes in peripheral thyroid hormones. Data on thyroid hormones in critically ill children remain unclear. Read More

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http://dx.doi.org/10.3889/oamjms.2019.262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6490479PMC
April 2019
7 Reads

Spectrum of Thyroid Abnormalities among Children Living with HIV in Lagos, Nigeria.

J Thyroid Res 2019 21;2019:1096739. Epub 2019 Mar 21.

Department of Pediatrics, College of Medicine, University of Lagos/Lagos University Teaching Hospital, Nigeria.

Thyroid disorders have been described in an adult population but are underreported in the pediatric population. The aim of this study was to determine the prevalence and describe the spectrum of thyroid abnormalities among HIV infected children on Highly Active Antiretroviral Therapy (HAART) in Lagos, Nigeria. This was a cross-sectional study carried out at a teaching hospital with an antiretroviral therapy (ART) center. Read More

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http://dx.doi.org/10.1155/2019/1096739DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448344PMC
March 2019
8 Reads

Relationships of Chronic Kidney Disease and Thyroid Dysfunction in Non-Dialysis Patients: A Pilot Study.

Kidney Blood Press Res 2019 23;44(2):170-178. Epub 2019 Apr 23.

Department of Nephrology, Sir Run Run Hospital, Nanjing Medical University, Nanjing, China,

Context: Patients with chronic kidney disease (CKD) usually manifest with disorder of thyroid hormone; however, the correlation is unknown.

Objective: The study was designed to explore the relationships between CKD and thyroid dysfunction.

Design, Setting, And Participants: A total number of 905 non-dialysis participants were collected at Nanjing First Hospital from August 2009 to October 2012 according to the case records system. Read More

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http://dx.doi.org/10.1159/000499201DOI Listing
December 2019
13 Reads

The Role of Thyroid Hormones in Heart Failure.

Cardiovasc Drugs Ther 2019 04;33(2):179-188

Departamento de Cirurgia e Fisiologia, Unidade de Investigação Cardiovascular, Faculdade de Medicina da Universidade do Porto, Alameda Professor Hernâni Monteiro, 4200-319, Porto, Portugal.

Cardiovascular diseases are the leading cause of death worldwide. Heart failure is the terminal manifestation of cardiovascular diseases, and its morbidity and mortality remain high. The prevalence of heart failure with preserved ejection fraction (HFpEF) among heart failure patients remains uncertain. Read More

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http://dx.doi.org/10.1007/s10557-019-06870-4DOI Listing
April 2019
9 Reads

The combination of nonthyroidal illness syndrome and renal dysfunction further increases mortality risk in patients with acute myocardial infarction: a prospective cohort study.

BMC Cardiovasc Disord 2019 03 4;19(1):50. Epub 2019 Mar 4.

Department of Cardiology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 600 Yishan Road, Shanghai, 200233, China.

Background: Both nonthyroidal illness syndrome and renal dysfunction are associated with increased mortality risk in acute myocardial infarction (AMI). However, it is unclear whether combined NTIS and renal dysfunction further increase mortality risk. Therefore, our aim is to investigate whether combined NTIS and renal dysfunction further increases mortality risk in patients with acute myocardial infarction (AMI). Read More

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http://dx.doi.org/10.1186/s12872-019-1027-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398216PMC
March 2019
22 Reads

Thyroid Hormones in Critical Illness.

Crit Care Clin 2019 Apr 24;35(2):375-388. Epub 2019 Jan 24.

Endocrine and Metabolic Unit, Royal Adelaide Hospital, Port Road, Adelaide, South Australia 5000, Australia.

Thyroid hormone is integral for normal function, yet during illness, circulating levels of the most active form (triiodothyronine [T3]) decline. Whether this is an adaptive response in critical illness or contributes to progressive disease has remained controversial. This review outlines the basis of thyroid hormone changes during critical illness and considers the evidence regarding T3 replacement. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07490704183078
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http://dx.doi.org/10.1016/j.ccc.2018.11.012DOI Listing
April 2019
17 Reads
2.495 Impact Factor

Non-Thyroidal Illness Syndrome in Critically Ill Children: Prognostic Value and Impact of Nutritional Management.

Thyroid 2019 04 11;29(4):480-492. Epub 2019 Mar 11.

1 Clinical Division and Laboratory of Intensive Care Medicine, Department of Cellular and Molecular Medicine, KU Leuven University Hospital, Leuven, Belgium.

Introduction: Non-thyroidal illness (NTI), which occurs with fasting and in response to illness, is characterized by thyroid hormone inactivation with low triiodothyronine (T3) and high reverse T3 (rT3), followed by suppressed thyrotropin (TSH). Withholding supplemental parenteral nutrition early in pediatric critical illness (late-PN), thus accepting low/no macronutrient intake up to day 8 in the pediatric intensive care unit (PICU), accelerated recovery compared to initiating supplemental parenteral nutrition early (early-PN). Whether NTI is harmful or beneficial in pediatric critical illness and how it is affected by a macronutrient deficit remains unclear. Read More

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http://dx.doi.org/10.1089/thy.2018.0420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457888PMC
April 2019
3 Reads

Low T3 Syndrome Is Associated With High Mortality in Hospitalized Patients With Heart Failure.

J Card Fail 2019 Mar 23;25(3):195-203. Epub 2019 Jan 23.

Department of Cardiovascular Medicine, Fukushima Medical University, Fukushima, Japan.

Background: We aimed to clarify the prognosis and pathophysiological parameters of low T3 syndrome in patients with heart failure (HF).

Methods And Results: Hospitalized patients with HF and euthyroidism (n = 911) were divided into 2 groups on the basis of free triiodothyronine (FT3) serum levels: the normal FT3 group (FT3 ≥2.3 pg/mL; n = 590; 64. Read More

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http://dx.doi.org/10.1016/j.cardfail.2019.01.007DOI Listing
March 2019
19 Reads

Thyroid Dysfunction in Heart Failure and Cardiovascular Outcomes.

Circ Heart Fail 2018 12;11(12):e005266

Division of Endocrinology, Diabetes, and Metabolism (L.K., A.R.C.) at the Perelman School of Medicine at the University of Pennsylvania, Philadelphia.

Background: The effects of thyroid dysfunction in patients with preexisting heart failure have not been adequately studied. We examined the prevalence of thyroid dysfunction and associations with cardiovascular outcomes in a large, prospective cohort of outpatients with preexisting heart failure.

Methods And Results: We examined associations between thyroid dysfunction and New York Heart Association class, atrial fibrillation, and a composite end point of ventricular assist device placement, heart transplantation, or death in 1365 participants with heart failure enrolled in the Penn Heart Failure Study. Read More

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.118.005266DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352308PMC
December 2018
36 Reads

Serum levels of fetuin-A are negatively associated with log transformation levels of thyroid-stimulating hormone in patients with hyperthyroidism or euthyroidism: An observational study at a medical center in Taiwan.

Medicine (Baltimore) 2018 Nov;97(46):e13254

Department of Internal Medicine, National Taiwan University Hospital, and National Taiwan University College of Medicine.

Fetuin-A is a protein with various biological functions. It plays a role in insulin resistance and arterial calcium deposition. Thyroid dysfunction may affect energy expenditure, glucose metabolism, and the risk of cardiovascular diseases. Read More

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http://dx.doi.org/10.1097/MD.0000000000013254DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257609PMC
November 2018
34 Reads

Adequate restitution in primary hypothyroidism depending on levothyroxine formulations

Rev Med Inst Mex Seguro Soc 2018 Oct 25;56(3):255-260. Epub 2018 Oct 25.

Universidad Autónoma de Nuevo León, Facultad de Medicina, Subdirección de Investigación. Monterrey, Nuevo León, México

Background: The prevalence of primary hypothyroidism (PH) is around 3.8%-4.6% in general population. Read More

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October 2018
18 Reads

Thyroid dysfunction in children with leukemia over the first year after hematopoietic stem cell transplantation.

J Pediatr Endocrinol Metab 2018 Nov;31(11):1241-1247

Department of Pediatrics, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea.

Background Thyroid function in children with leukemia during the first year after hematopoietic stem cell transplantation (HSCT) was investigated. Methods The medical records of 186 subjects [111 boys and 75 girls; lymphoid=75, myeloid=111; median age at HSCT was 10.7 (0. Read More

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http://dx.doi.org/10.1515/jpem-2018-0162DOI Listing
November 2018
13 Reads
0.711 Impact Factor

Rare case of meningococcal sepsis-induced testicular failure, primary hypothyroidism and hypoadrenalism: Is there a link?

BMJ Case Rep 2018 Sep 15;2018. Epub 2018 Sep 15.

Townsville Hospital, Townsville, Queensland, Australia.

Severe illness can lead to multiple transient endocrinopathies. In adult patients, neuroendocrine alterations include sick euthyroid syndrome, an increase in corticosteroid levels, increase in prolactin levels, decreased insulin growth factor 1 levels and hypogonadism. We report the case of a 24-year-old man with meningococcal sepsis with multiple end-organ complications who developed persistent non-autoimmune hypothyroidism, adrenal insufficiency and primary hypogonadism all requiring hormone replacement. Read More

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http://dx.doi.org/10.1136/bcr-2018-224437DOI Listing
September 2018
11 Reads

Preoperative oral thyroid hormones to prevent euthyroid sick syndrome and attenuate myocardial ischemia-reperfusion injury after cardiac surgery with cardiopulmonary bypass in children: A randomized, double-blind, placebo-controlled trial.

Medicine (Baltimore) 2018 Sep;97(36):e12100

Department of Anesthesiology, Henan Provincial People's Hospital of Zhengzhou University, Zhengzhou.

Background: Both euthyroid sick syndrome and myocardial ischemia-reperfusion injury are common and have been significantly associated with morbidity and mortality after pediatric cardiac surgery with cardiopulmonary bypass. This single-center, prospective, double-blind, randomized placebo-controlled clinical pilot trial was designed to assess if preoperative oral thyroid hormone therapy could prevent the occurrence of euthyroid sick syndrome (ESS) and attenuate myocardial ischemia-reperfusion injury (IRI) after cardiac surgery with cardiopulmonary bypass (CPB) in children.

Methods: Forty children aged 3 to 12 year, scheduled for elective congenital heart disease repair surgery with CPB, were randomized into 2 groups of equal size to receive the following treatments in a double-blind manner: placebo (control group) and thyroid tablet 0. Read More

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http://dx.doi.org/10.1097/MD.0000000000012100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6133632PMC
September 2018
119 Reads
5.720 Impact Factor

The relationship between inflammatory factors, oxidative stress and DIO-1 concentration in patients with chronic renal failure accompanied with or without euthyroid sick syndrome.

J Int Med Res 2018 Oct 28;46(10):4061-4070. Epub 2018 Aug 28.

2 Department of Nephrology, Second Affiliated Hospital, Nanchang University, Nanchang, Jiangxi Province, China.

Objective To investigate the relationship between inflammatory factors, oxidative stress and type 1 deiodinase (DIO-1) concentration in patients with chronic renal failure (CRF) with or without euthyroid sick syndrome (ESS). Methods This study recruited patients with CRF and divided them into two groups: group 1 had low free triiodothyronine (FT3) levels; and group 2 had normal FT3 levels. Group 3 consisted of healthy volunteers. Read More

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http://dx.doi.org/10.1177/0300060518778190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6166338PMC
October 2018
76 Reads

Alterations in thyroid hormones in brain-dead patients are related to non-thyroidal illness syndrome.

Endokrynol Pol 2018 22;69(5):545-549. Epub 2018 Aug 22.

Department of Internal Medicine, Section of Critical Care, School of Medicine, Düzce University, Düzce, Turkey.

Introduction: Alterations in thyroid hormone levels occur in patients with acute neurological disease states. The aim of this study is to study changes in thyroid hormones in patients with brain death (BD).

Material And Methods: Eleven brain-dead patients were studied prospectively. Read More

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http://dx.doi.org/10.5603/EP.a2018.0056DOI Listing
April 2019
19 Reads

Obesity without comorbidity may also lead to non-thyroidal illness syndrome.

Adv Clin Exp Med 2018 Nov;27(11):1515-1520

Department of Internal Medicine, Numune Training and Research Hospital, Adana, Turkey.

Background: Obesity mediates a series of operations in the body by increasing the production of proinflammatory cytokines. Cytokines play an important role in the development of non-thyroidal illness syndrome (NTIS).

Objectives: The aim of this study was to investigate the association between obesity and NTIS. Read More

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http://dx.doi.org/10.17219/acem/70226DOI Listing
November 2018
7 Reads

Prognostic Value of Thyroid Profile in Critical Care Condition.

Indian J Endocrinol Metab 2018 May-Jun;22(3):387-391

Department of Endocrinology, LLRM Medical College, Meerut, Uttar Pradesh, India.

Background: Patients suffering from critical illness admitted to the Intensive Care Unit (ICU) exhibit alterations in their thyroid hormone levels, collectively termed as euthyroid sick syndrome or nonthyroidal illness syndrome. Our study was conducted to determine the correlation between these changes in thyroid hormone levels and the prognosis of ICU-admitted patients.

Methods: A total of 270 ICU-admitted patients without previous history of thyroid disorder were included in the study. Read More

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http://dx.doi.org/10.4103/ijem.IJEM_20_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063192PMC
August 2018
27 Reads

Relationship between disease severity and thyroid function in Chinese patients with euthyroid sick syndrome.

Medicine (Baltimore) 2018 Aug;97(31):e11756

Department of ICU, The People's Hospital of Wuxi, Wuxi, China.

Euthyroid sick syndrome (ESS) is commonly observed in various acute and chronic illness as risk factor for mortality in patients with severe diseases, with lower triiodothyronine (T3) and free triiodothyronine (fT3).To explore the relationship between disease severity and thyroid function in critically ill Chinese patients with ESS.A total of 51 patients admitted to intensive care unit were examined to determine acute physiology and chronic health assessment II (APACHE II) scores within 24 hours of admission; thyroid function tests (TSH, fT3, fT4, tT3, tT4) and rT3 levels were determined on the second day. Read More

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http://dx.doi.org/10.1097/MD.0000000000011756DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081175PMC
August 2018
11 Reads

Prognostic significance of high free T4 and low free T3 levels in non-thyroidal illness syndrome.

Eur J Intern Med 2018 11 18;57:91-95. Epub 2018 Jul 18.

Health Sciences faculty, İstanbul Esenyurt University, Turkey.

Background: Non-thyroidal illness syndrome is characterized by decreased serum free T3 (FT3) level and associates with long term mortality. Serum free T4 (FT4) may affect on mortality with FT3 in course of chronic illness. This study performed to evaluate the association between both decreased FT3 with elevated FT4 levels and mortality risk. Read More

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http://dx.doi.org/10.1016/j.ejim.2018.07.018DOI Listing
November 2018
12 Reads

Investigation of the Oxidative Stress and DIO1 Expression in CRF Patients Accompanied With and Without Euthyroid Sick Syndrome.

Kidney Blood Press Res 2018 7;43(3):924-930. Epub 2018 Jun 7.

Department of Endocrinology, Third Affiliated Hospital, Nanchang University, Nanchang, China.

Background/aims: Chronic renal failure (CRF) is often accompanied by increased oxidative stress and euthyroid sick syndrome (ESS). The cause of ESS is unknown, and it is unknown whether there exists a link between oxidant stress and ESS in CRF patients. Therefore, we aim to investigate oxidative stress and type 1 deiodinase (DIO1) expression, which plays the key role in the ESS in CRF patients. Read More

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http://dx.doi.org/10.1159/000490471DOI Listing
October 2018
72 Reads

[ABNORMALITIES OF THYROID HORMONE METABOLISM DURING COMMUNITY‒ACQUIRED PNEUMONIA: NONTHYROIDAL ILLNESS SYNDROME AND INTRACELLULAR IODINE DISTRIBUTION IN CHILDREN].

Georgian Med News 2018 Mar(276):60-65

«I. Horbachevsky Ternopil State Medical University» Ukraine.

The aim of the study ‒ to investigate the changes of thyroid function and to reveal the relationship in between intracellular distribution of iodine in the blood with the severity of the course of pneumonia in children. We investigated 70 patients in age 6-14 years with moderate and severe CAP and 35 healthy children. The levels of free thyroxine (fT4), free triiodo-thyronine (fT3) and thyroid stimulating hormone, thyroid gland ultrasound and urinary iodine were estimated. Read More

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March 2018
4 Reads

[Prevalence and prognostic value of non-thyroidal illness syndrome among critically ill children].

An Pediatr (Barc) 2019 Apr 5;90(4):237-243. Epub 2018 Apr 5.

Departamento de Pediatría, Facultad de Medicina, Universidad de Menufia, Shibin El-Kom, Menufia, Egipto.

Introduction: Alterations in thyroid hormones during critical illness, known as non-thyroidal illness syndrome (NTIS), were suggested to have a prognostic value. However, pediatric data is limited. The aim of this study was to assess prevalence and prognostic value of NTIS among critically ill children. Read More

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http://dx.doi.org/10.1016/j.anpedi.2018.01.021DOI Listing
April 2019
16 Reads

Higher free triiodothyronine concentration is associated with lower prevalence of microangiopathic complications and better metabolic control in adult euthyroid people with type 1 diabetes.

Endocrine 2018 06 30;60(3):458-465. Epub 2018 Mar 30.

Department of Internal Medicine and Diabetology, Poznan University of Medical Sciences, Mickiewicza 2, Poznan, 60-834, Poland.

Purpose: Type 1 diabetes mellitus (T1DM) is a disorder of insulin deficiency but with a wide range of hormones simultaneously disturbed. The study was performed to explore relation of free triiodothyronine (FT3) with metabolic control and occurrence of microangiopathic complications.

Methods: A total of 266 adult T1DM participants [56% men; 32 (interquartile range, IQR: 25-39) years and disease duration 13 (IQR: 8-19) years] in euthyroid state with negative history for hypothyroidism were included to the study. Read More

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http://dx.doi.org/10.1007/s12020-018-1582-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5937901PMC
June 2018
21 Reads

Low T3 syndrome improves risk prediction of in-hospital cardiovascular death in patients with acute myocardial infarction.

J Cardiol 2018 09 23;72(3):215-219. Epub 2018 Mar 23.

Department of Cardiology, Beijing Friendship Hospital, Capital Medical University, Beijing, PR China. Electronic address:

Background: Low triiodothyronine (T3) syndrome (LT3S) is frequently seen in patients with acute myocardial infarction (AMI). We examined the association between LT3S and severity of myocardial injury and determined whether LT3S adds predictive value over thrombolysis in myocardial infarction (TIMI) risk score for in-hospital cardiovascular (CV) death.

Methods: Of 2459 AMI patients, 529 pairs of euthyroid and LT3S individuals with similar baseline characteristics were identified using 1:1 propensity score matching. Read More

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http://dx.doi.org/10.1016/j.jjcc.2018.02.013DOI Listing
September 2018
90 Reads
2.570 Impact Factor

Prevalence and Related Factors of Euthyroid Sick Syndrome in Children with Untreated Cancer According to Two Different Criteria

J Clin Res Pediatr Endocrinol 2018 07 19;10(3):198-205. Epub 2018 Mar 19.

Mersin University Faculty of Medicine, Department of Internal Medicine, Division of Endocrinology and Metabolism, Mersin, Turkey

Objective: In this study, we evaluated the frequency of euthyroid sick syndrome (ESS) among patients with childhood cancer and its association with the stage of disease, nutritional parameters and cytokines levels.

Methods: Eighty newly diagnosed children were included in the study. ESS was assessed in two different ways. Read More

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http://dx.doi.org/10.4274/jcrpe.0015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6083463PMC
July 2018
16 Reads