692 results match your criteria Euthyroid Sick Syndrome


The Role of Thyroid Hormones in Heart Failure.

Cardiovasc Drugs Ther 2019 Mar 7. Epub 2019 Mar 7.

Departamento de Cirurgia e Fisiologia, Unidade de Investigação Cardiovascular, Faculdade de Medicina da Universidade do Porto, Alameda Professor Hernâni Monteiro, 4200-319, Porto, Portugal.

Cardiovascular diseases are the leading cause of death worldwide. Heart failure is the terminal manifestation of cardiovascular diseases, and its morbidity and mortality remain high. The prevalence of heart failure with preserved ejection fraction (HFpEF) among heart failure patients remains uncertain. Read More

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http://dx.doi.org/10.1007/s10557-019-06870-4DOI Listing
March 2019
1 Read

Thyroid Hormones in Critical Illness.

Crit Care Clin 2019 Apr 24;35(2):375-388. Epub 2019 Jan 24.

Endocrine and Metabolic Unit, Royal Adelaide Hospital, Port Road, Adelaide, South Australia 5000, Australia.

Thyroid hormone is integral for normal function, yet during illness, circulating levels of the most active form (triiodothyronine [T3]) decline. Whether this is an adaptive response in critical illness or contributes to progressive disease has remained controversial. This review outlines the basis of thyroid hormone changes during critical illness and considers the evidence regarding T3 replacement. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07490704183078
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http://dx.doi.org/10.1016/j.ccc.2018.11.012DOI Listing
April 2019
6 Reads
2.495 Impact Factor

Low T3 Syndrome Is Associated With High Mortality in Hospitalized Patients With Heart Failure.

J Card Fail 2019 Mar 23;25(3):195-203. Epub 2019 Jan 23.

Department of Cardiovascular Medicine, Fukushima Medical University, Fukushima, Japan.

Background: We aimed to clarify the prognosis and pathophysiological parameters of low T3 syndrome in patients with heart failure (HF).

Methods And Results: Hospitalized patients with HF and euthyroidism (n = 911) were divided into 2 groups on the basis of free triiodothyronine (FT3) serum levels: the normal FT3 group (FT3 ≥2.3 pg/mL; n = 590; 64. Read More

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http://dx.doi.org/10.1016/j.cardfail.2019.01.007DOI Listing
March 2019
7 Reads

Thyroid Dysfunction in Heart Failure and Cardiovascular Outcomes.

Circ Heart Fail 2018 Dec;11(12):e005266

Division of Endocrinology, Diabetes, and Metabolism (L.K., A.R.C.) at the Perelman School of Medicine at the University of Pennsylvania, Philadelphia.

Background: The effects of thyroid dysfunction in patients with preexisting heart failure have not been adequately studied. We examined the prevalence of thyroid dysfunction and associations with cardiovascular outcomes in a large, prospective cohort of outpatients with preexisting heart failure.

Methods And Results: We examined associations between thyroid dysfunction and New York Heart Association class, atrial fibrillation, and a composite end point of ventricular assist device placement, heart transplantation, or death in 1365 participants with heart failure enrolled in the Penn Heart Failure Study. Read More

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.118.005266DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352308PMC
December 2018
4 Reads

Serum levels of fetuin-A are negatively associated with log transformation levels of thyroid-stimulating hormone in patients with hyperthyroidism or euthyroidism: An observational study at a medical center in Taiwan.

Medicine (Baltimore) 2018 Nov;97(46):e13254

Department of Internal Medicine, National Taiwan University Hospital, and National Taiwan University College of Medicine.

Fetuin-A is a protein with various biological functions. It plays a role in insulin resistance and arterial calcium deposition. Thyroid dysfunction may affect energy expenditure, glucose metabolism, and the risk of cardiovascular diseases. Read More

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http://dx.doi.org/10.1097/MD.0000000000013254DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257609PMC
November 2018
12 Reads

Adequate restitution in primary hypothyroidism depending on levothyroxine formulations

Rev Med Inst Mex Seguro Soc 2018 Oct 25;56(3):255-260. Epub 2018 Oct 25.

Universidad Autónoma de Nuevo León, Facultad de Medicina, Subdirección de Investigación. Monterrey, Nuevo León, México

Background: The prevalence of primary hypothyroidism (PH) is around 3.8%-4.6% in general population. Read More

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October 2018
4 Reads

Thyroid dysfunction in children with leukemia over the first year after hematopoietic stem cell transplantation.

J Pediatr Endocrinol Metab 2018 Nov;31(11):1241-1247

Department of Pediatrics, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea.

Background Thyroid function in children with leukemia during the first year after hematopoietic stem cell transplantation (HSCT) was investigated. Methods The medical records of 186 subjects [111 boys and 75 girls; lymphoid=75, myeloid=111; median age at HSCT was 10.7 (0. Read More

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http://dx.doi.org/10.1515/jpem-2018-0162DOI Listing
November 2018
4 Reads
0.711 Impact Factor

Rare case of meningococcal sepsis-induced testicular failure, primary hypothyroidism and hypoadrenalism: Is there a link?

BMJ Case Rep 2018 Sep 15;2018. Epub 2018 Sep 15.

Townsville Hospital, Townsville, Queensland, Australia.

Severe illness can lead to multiple transient endocrinopathies. In adult patients, neuroendocrine alterations include sick euthyroid syndrome, an increase in corticosteroid levels, increase in prolactin levels, decreased insulin growth factor 1 levels and hypogonadism. We report the case of a 24-year-old man with meningococcal sepsis with multiple end-organ complications who developed persistent non-autoimmune hypothyroidism, adrenal insufficiency and primary hypogonadism all requiring hormone replacement. Read More

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http://dx.doi.org/10.1136/bcr-2018-224437DOI Listing
September 2018
3 Reads

Preoperative oral thyroid hormones to prevent euthyroid sick syndrome and attenuate myocardial ischemia-reperfusion injury after cardiac surgery with cardiopulmonary bypass in children: A randomized, double-blind, placebo-controlled trial.

Medicine (Baltimore) 2018 Sep;97(36):e12100

Department of Anesthesiology, Henan Provincial People's Hospital of Zhengzhou University, Zhengzhou.

Background: Both euthyroid sick syndrome and myocardial ischemia-reperfusion injury are common and have been significantly associated with morbidity and mortality after pediatric cardiac surgery with cardiopulmonary bypass. This single-center, prospective, double-blind, randomized placebo-controlled clinical pilot trial was designed to assess if preoperative oral thyroid hormone therapy could prevent the occurrence of euthyroid sick syndrome (ESS) and attenuate myocardial ischemia-reperfusion injury (IRI) after cardiac surgery with cardiopulmonary bypass (CPB) in children.

Methods: Forty children aged 3 to 12 year, scheduled for elective congenital heart disease repair surgery with CPB, were randomized into 2 groups of equal size to receive the following treatments in a double-blind manner: placebo (control group) and thyroid tablet 0. Read More

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http://dx.doi.org/10.1097/MD.0000000000012100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6133632PMC
September 2018
62 Reads
5.720 Impact Factor

The relationship between inflammatory factors, oxidative stress and DIO-1 concentration in patients with chronic renal failure accompanied with or without euthyroid sick syndrome.

J Int Med Res 2018 Oct 28;46(10):4061-4070. Epub 2018 Aug 28.

2 Department of Nephrology, Second Affiliated Hospital, Nanchang University, Nanchang, Jiangxi Province, China.

Objective To investigate the relationship between inflammatory factors, oxidative stress and type 1 deiodinase (DIO-1) concentration in patients with chronic renal failure (CRF) with or without euthyroid sick syndrome (ESS). Methods This study recruited patients with CRF and divided them into two groups: group 1 had low free triiodothyronine (FT3) levels; and group 2 had normal FT3 levels. Group 3 consisted of healthy volunteers. Read More

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http://dx.doi.org/10.1177/0300060518778190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6166338PMC
October 2018
41 Reads

Alterations in thyroid hormones in brain-dead patients are related to non-thyroidal illness syndrome.

Endokrynol Pol 2018 22;69(5):545-549. Epub 2018 Aug 22.

Department of Internal Medicine, Section of Critical Care, School of Medicine, Düzce University, Düzce, Turkey.

Introduction: Alterations in thyroid hormone levels occur in patients with acute neurological disease states. The aim of this study is to study changes in thyroid hormones in patients with brain death (BD).

Material And Methods: Eleven brain-dead patients were studied prospectively. Read More

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http://dx.doi.org/10.5603/EP.a2018.0056DOI Listing
April 2019
10 Reads

Prognostic Value of Thyroid Profile in Critical Care Condition.

Indian J Endocrinol Metab 2018 May-Jun;22(3):387-391

Department of Endocrinology, LLRM Medical College, Meerut, Uttar Pradesh, India.

Background: Patients suffering from critical illness admitted to the Intensive Care Unit (ICU) exhibit alterations in their thyroid hormone levels, collectively termed as euthyroid sick syndrome or nonthyroidal illness syndrome. Our study was conducted to determine the correlation between these changes in thyroid hormone levels and the prognosis of ICU-admitted patients.

Methods: A total of 270 ICU-admitted patients without previous history of thyroid disorder were included in the study. Read More

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http://dx.doi.org/10.4103/ijem.IJEM_20_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063192PMC
August 2018
6 Reads

Relationship between disease severity and thyroid function in Chinese patients with euthyroid sick syndrome.

Medicine (Baltimore) 2018 Aug;97(31):e11756

Department of ICU, The People's Hospital of Wuxi, Wuxi, China.

Euthyroid sick syndrome (ESS) is commonly observed in various acute and chronic illness as risk factor for mortality in patients with severe diseases, with lower triiodothyronine (T3) and free triiodothyronine (fT3).To explore the relationship between disease severity and thyroid function in critically ill Chinese patients with ESS.A total of 51 patients admitted to intensive care unit were examined to determine acute physiology and chronic health assessment II (APACHE II) scores within 24 hours of admission; thyroid function tests (TSH, fT3, fT4, tT3, tT4) and rT3 levels were determined on the second day. Read More

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http://dx.doi.org/10.1097/MD.0000000000011756DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081175PMC
August 2018
3 Reads

Prognostic significance of high free T4 and low free T3 levels in non-thyroidal illness syndrome.

Eur J Intern Med 2018 11 18;57:91-95. Epub 2018 Jul 18.

Health Sciences faculty, İstanbul Esenyurt University, Turkey.

Background: Non-thyroidal illness syndrome is characterized by decreased serum free T3 (FT3) level and associates with long term mortality. Serum free T4 (FT4) may affect on mortality with FT3 in course of chronic illness. This study performed to evaluate the association between both decreased FT3 with elevated FT4 levels and mortality risk. Read More

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http://dx.doi.org/10.1016/j.ejim.2018.07.018DOI Listing
November 2018
7 Reads

Investigation of the Oxidative Stress and DIO1 Expression in CRF Patients Accompanied With and Without Euthyroid Sick Syndrome.

Kidney Blood Press Res 2018 7;43(3):924-930. Epub 2018 Jun 7.

Department of Endocrinology, Third Affiliated Hospital, Nanchang University, Nanchang, China.

Background/aims: Chronic renal failure (CRF) is often accompanied by increased oxidative stress and euthyroid sick syndrome (ESS). The cause of ESS is unknown, and it is unknown whether there exists a link between oxidant stress and ESS in CRF patients. Therefore, we aim to investigate oxidative stress and type 1 deiodinase (DIO1) expression, which plays the key role in the ESS in CRF patients. Read More

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http://dx.doi.org/10.1159/000490471DOI Listing
October 2018
33 Reads

[ABNORMALITIES OF THYROID HORMONE METABOLISM DURING COMMUNITY‒ACQUIRED PNEUMONIA: NONTHYROIDAL ILLNESS SYNDROME AND INTRACELLULAR IODINE DISTRIBUTION IN CHILDREN].

Georgian Med News 2018 Mar(276):60-65

«I. Horbachevsky Ternopil State Medical University» Ukraine.

The aim of the study ‒ to investigate the changes of thyroid function and to reveal the relationship in between intracellular distribution of iodine in the blood with the severity of the course of pneumonia in children. We investigated 70 patients in age 6-14 years with moderate and severe CAP and 35 healthy children. The levels of free thyroxine (fT4), free triiodo-thyronine (fT3) and thyroid stimulating hormone, thyroid gland ultrasound and urinary iodine were estimated. Read More

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[Prevalence and prognostic value of non-thyroidal illness syndrome among critically ill children].

An Pediatr (Barc) 2019 Apr 5;90(4):237-243. Epub 2018 Apr 5.

Departamento de Pediatría, Facultad de Medicina, Universidad de Menufia, Shibin El-Kom, Menufia, Egipto.

Introduction: Alterations in thyroid hormones during critical illness, known as non-thyroidal illness syndrome (NTIS), were suggested to have a prognostic value. However, pediatric data is limited. The aim of this study was to assess prevalence and prognostic value of NTIS among critically ill children. Read More

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http://dx.doi.org/10.1016/j.anpedi.2018.01.021DOI Listing
April 2019
8 Reads

Higher free triiodothyronine concentration is associated with lower prevalence of microangiopathic complications and better metabolic control in adult euthyroid people with type 1 diabetes.

Endocrine 2018 06 30;60(3):458-465. Epub 2018 Mar 30.

Department of Internal Medicine and Diabetology, Poznan University of Medical Sciences, Mickiewicza 2, Poznan, 60-834, Poland.

Purpose: Type 1 diabetes mellitus (T1DM) is a disorder of insulin deficiency but with a wide range of hormones simultaneously disturbed. The study was performed to explore relation of free triiodothyronine (FT3) with metabolic control and occurrence of microangiopathic complications.

Methods: A total of 266 adult T1DM participants [56% men; 32 (interquartile range, IQR: 25-39) years and disease duration 13 (IQR: 8-19) years] in euthyroid state with negative history for hypothyroidism were included to the study. Read More

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http://dx.doi.org/10.1007/s12020-018-1582-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5937901PMC
June 2018
12 Reads

Prevalence and Related Factors of Euthyroid Sick Syndrome in Children with Untreated Cancer According to Two Different Criteria

J Clin Res Pediatr Endocrinol 2018 07 19;10(3):198-205. Epub 2018 Mar 19.

Mersin University Faculty of Medicine, Department of Internal Medicine, Division of Endocrinology and Metabolism, Mersin, Turkey

Objective: In this study, we evaluated the frequency of euthyroid sick syndrome (ESS) among patients with childhood cancer and its association with the stage of disease, nutritional parameters and cytokines levels.

Methods: Eighty newly diagnosed children were included in the study. ESS was assessed in two different ways. Read More

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http://dx.doi.org/10.4274/jcrpe.0015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6083463PMC
July 2018
5 Reads

Low T3 syndrome as a predictor of poor prognosis in chronic lymphocytic leukemia.

Int J Cancer 2018 08 2;143(3):466-477. Epub 2018 Mar 2.

Department of Hematology, the First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing, 210029, China.

Low triiodothyronine (T3) state is associated with poor prognosis in critical acute and prolonged illness. However, the information on thyroid dysfunction and cancer is limited. The aim of our study was to evaluate the prognostic value of low T3 syndrome in chronic lymphocytic leukemia (CLL). Read More

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http://dx.doi.org/10.1002/ijc.31327DOI Listing
August 2018
10 Reads

The non-thyroidal illness syndrome is associated with postoperative surgical site infections in enterocutaneous fistulae.

Int J Surg 2018 Mar 7;51:213-217. Epub 2018 Feb 7.

Department of General Surgery, Jinling Hospital, China.

Background: Non-thyroidal illness syndrome (NTIS) is common in critically ill patients and associated with adverse outcomes. Many enterocutaneous fistula (ECF) patients still suffer NTIS prior to definitive surgery. This study was designed to explore the association between preoperative NTIS and postoperative outcomes in ECF patients. Read More

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http://dx.doi.org/10.1016/j.ijsu.2018.02.001DOI Listing
March 2018
10 Reads

Nonthyroidal Illness Syndrome and Thyroid Hormone Actions at Integrin αvβ3.

J Clin Endocrinol Metab 2018 04;103(4):1291-1295

Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Albany, New York.

Context: The nonthyroidal illness syndrome (NTIS) is a constellation of changes in circulating thyroid hormone levels that occur in euthyroid patients with acute or chronic systemic diseases. The changes that occur include a reduction in serum T3, an increase in serum rT3, and variable changes in circulating T4 levels. No consensus exists regarding therapeutic intervention for NTIS. Read More

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http://dx.doi.org/10.1210/jc.2017-01939DOI Listing
April 2018
13 Reads

[Euthyroid sick syndrome: an important clinical problem].

Wiad Lek 2017;70(2 pt 2):376-385

Klinika Chorob Wewnętrznych i Farmakologii Klinicznej Katedry Farmakologii Śląskiego Uniwersytetu Medycznego w Katowicach, Polska.

Despite absence of thyroid disease, patients with non-thyroidal illness frequently have changes in serum thyroid hormone measurements that may suggest thyroid dysfunction. These abnormalities include low serum triiodothyronine, high reverse triiodothyronine and usually normal or inappropriately low thyrotropin and thyroxine levels. The degree of thyroid function impairment correlates with disease severity and low levels of thyroid hormones, particularly thyroxine, predict a poor prognosis. Read More

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January 2017
13 Reads

Role of thyroid hormone in skeletal muscle physiology.

J Endocrinol 2018 Jan 19;236(1):R57-R68. Epub 2017 Oct 19.

Institute of Biophysics Carlos Chagas FilhoLaboratory of Translational Endocrinology, Rio de Janeiro, Brazil.

Thyroid hormones (TH) are crucial for development, growth, differentiation, metabolism and thermogenesis. Skeletal muscle (SM) contractile function, myogenesis and bioenergetic metabolism are influenced by TH. These effects depend on the presence of the TH transporters MCT8 and MCT10 in the plasma membrane, the expression of TH receptors (THRA or THRB) and hormone availability, which is determined either by the activation of thyroxine (T) into triiodothyronine (T) by type 2 iodothyronine deiodinases (D2) or by the inactivation of T into reverse T by deiodinases type 3 (D3). Read More

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http://dx.doi.org/10.1530/JOE-16-0611DOI Listing
January 2018
6 Reads

Effects of Anorexia Nervosa on the Endocrine System.

Pediatr Endocrinol Rev 2017 Mar;14(3):302-311

Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

Anorexia nervosa (AN) is characterized by severe undernutrition associated with alterations in multiple endocrine axes, which are primarily adaptive to the state of caloric deprivation. Hormonal changes include growth hormone (GH) resistance with low insulin like growth factor-1 (IGF-1) levels, hypothalamic hypogonadism, relative hypercortisolemia and changes in appetite regulating hormones, including leptin, ghrelin, and peptide YY. These alterations contribute to abnormalities in bone metabolism leading to low bone mass, impaired bone microarchitecture, and increased risk for fracture, and may also negatively impact cognition, emotions and mood. Read More

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http://dx.doi.org/10.17458/per.vol14.2017.BMK.effectsanorexianervosaDOI Listing
March 2017
52 Reads

Thyroid Dysfunctions in a Sample of Egyptian Children and Adolescents with Systemic Lupus Erythematosus: Relation to Disease Activity and Duration.

Egypt J Immunol 2016 Jun;23(2):65-73

Department of Pediatrics, Faculty of Medicine, Tanta University, Tanta, Egypt.

Systemic lupus erythematosus (SLE) is a chronic, autoimmune, inflammatory disease affects any organ of the body, including the thyroid gland. Both hypothyroidism and hyperthyroidism have been found in SLE patients more frequently than general population. The aim of this study was to evaluate the frequency of autoimmune thyroid dysfunctions in juvenile SLE and its relation to disease activity and duration. Read More

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June 2016
11 Reads

Pattern of Thyroid Disorders in Children and Adolescents Seen at the Lagos University Teaching Hospital, Nigeria, Over a 10-year Period.

Niger Med J 2017 May-Jun;58(3):101-106

Department of Paediatrics, College of Medicine, University of Lagos/Lagos University Teaching Hospital, Lagos, Nigeria.

Introduction: Thyroid disorders account for a large proportion of pediatric endocrine disorders. Untreated hypothyroidism in childhood has permanent adverse effects on physical, intellectual, and neurological development. However, few studies have reported the pattern of pediatric thyroid disorders in Nigeria. Read More

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http://dx.doi.org/10.4103/nmj.NMJ_156_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009143PMC
July 2018
29 Reads

Subclinical hypothyroidism and the risk of chronic kidney disease in T2D subjects: A case-control and dose-response analysis.

Medicine (Baltimore) 2017 Apr;96(15):e6519

aDepartment of Endocrinology, Beijing Tongren Hospital, Capital Medical University, Beijing bDepartment of General Surgery, Weihaiwei People's Hospital, Weihai cCritical Care Medicine, Beijing Jiangong Hospital dBeijng Key Laboratory of Diabetes Research and Care, Beijing, China.

Evidence indicated a positive association between subclinical hypothyroidism (SCH) and cardiovascular diseases. But the relationship between SCH and chronic kidney diseases (CKD) remains unclear. A case-control study was performed to ascertain this relationship followed by a meta-analysis. Read More

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http://Insights.ovid.com/crossref?an=00005792-201704140-0001
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http://dx.doi.org/10.1097/MD.0000000000006519DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5403080PMC
April 2017
10 Reads

N-Acetylcysteine Prevents Low T3 Syndrome and Attenuates Cardiac Dysfunction in a Male Rat Model of Myocardial Infarction.

Endocrinology 2017 05;158(5):1502-1510

Thyroid Section, Endocrine Division, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre 90035-003, Rio Grande do Sul, Brazil.

Nonthyroidal illness syndrome (NTIS) affects patients with myocardial infarction (MI). Oxidative stress has been implicated as a causative factor of NTIS, and reversed via N-acetylcysteine (NAC). Male Wistar rats submitted to left anterior coronary artery occlusion received NAC or placebo. Read More

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http://dx.doi.org/10.1210/en.2016-1586DOI Listing
May 2017
26 Reads

Association of triiodothyronine levels with left ventricular function, cardiovascular events, and mortality in hemodialysis patients.

Int J Artif Organs 2017 03 28;40(2):60-66. Epub 2017 Feb 28.

Healthcare Department, Hainan Branch of the Chinese People's Liberation Army General Hospital, SanYa - China.

Background: Hemodialysis (HD) patients have altered free triiodothyronine (fT3) levels. A low fT3 level is a strong and inverse mortality predictor in HD patients. However, little is known about the relationship between fT3 and left ventricular function in HD patients. Read More

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http://dx.doi.org/10.5301/ijao.5000569DOI Listing
March 2017
9 Reads

Occult endocrine dysfunction in patients with cirrhosis of liver.

J Family Med Prim Care 2016 Jul-Sep;5(3):576-580

Department of Gastroenterology, Command Hospital, Chandimandir, Panchkula, Haryana, India.

Background: Liver dysfunction leads to endocrine disturbance due to the alteration in protein metabolism or synthesis. We studied the presence of occult endocrine dysfunction in liver cirrhosis and compared the same with underlying etiology.

Materials And Methods: We evaluated thirty patients with liver cirrhosis in this cross-sectional, observational study. Read More

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http://dx.doi.org/10.4103/2249-4863.197293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5290763PMC
February 2017
3 Reads

Low T3 syndrome is a strong prognostic predictor in diffuse large B cell lymphoma.

Br J Haematol 2017 04 1;177(1):95-105. Epub 2017 Feb 1.

Department of Haematology, the First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Collaborative Innovation Centre for Cancer Personalized Medicine, Nanjing, China.

The aim of this study was to evaluate the prognostic effect of low triiodothyronine (T3) syndrome on patients with diffuse large B cell lymphoma (DLBCL). A hundred and eighty-eight patients with detailed thyroid hormone levels at diagnosis of DLBCL were enrolled. Low T3 syndrome was defined as a low serum free T3 (FT3) level with low or normal serum free tetraiodothyronine (FT4) and thyroid stimulating hormone levels. Read More

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http://dx.doi.org/10.1111/bjh.14528DOI Listing
April 2017
30 Reads

Myocardial Inactivation of Thyroid Hormones in Patients with Aortic Stenosis.

Thyroid 2017 05 12;27(5):738-745. Epub 2017 Apr 12.

1 Heart Institute of the University of São Paulo Medical School , Sao Paulo, Brazil .

Objective: The human heart expresses the type 2 deiodinase (D2) that activates thyroxine (T4) to triiodothyronine (T3). At the same time, the inactivating type 3 deiodinase (D3) has been found in a rat model of right ventricular hypertrophy. It is not known whether the human myocardium metabolizes thyroid hormone. Read More

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http://dx.doi.org/10.1089/thy.2016.0514DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5749598PMC
May 2017
13 Reads

Retrospective evaluation of circulating thyroid hormones in critically ill dogs with systemic inflammatory response syndrome.

J Vet Sci 2017 Dec;18(4):471-477

Department of Veterinary Medical Sciences, Alma Mater Studiorum-University of Bologna, 40126 Bologna, Italy.

Critical illness can be associated with transient alterations in circulating thyroid hormone concentrations, indicating the presence of non-thyroidal illness (NTI). NTI is well described in humans, but there are few reports on its occurrence and prognostic significance in dogs. This retrospective study assessed the occurrence of NTI in a population of dogs with systemic inflammatory response syndrome (SIRS) and investigated its association with disease severity (APPLE scores). Read More

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http://dx.doi.org/10.4142/jvs.2017.18.4.471DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5746440PMC
December 2017
39 Reads

Thyroid disorders among dialysis patients

Rev Med Inst Mex Seguro Soc 2017 ;55(Suppl 2):S188-94

Hospital General Regional No. 1, Instituto Mexicano del Seguro Social, Morelia, Michoacán de Ocampo, México Correo electrónico:

The thyroid gland and the kidney are closely related. Thyroid hormones (TH) contribute to the homeostasis of the human being through complex interactions of fluids and electrolytes, protein synthesis, etc. The effects on the kidney of TH may be pre renal or direct actions. Read More

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October 2018
5 Reads

Impact of diabetic ketoacidosis on thyroid function tests in type 1 diabetes mellitus patients.

Diabetes Metab Syndr 2017 Nov 14;11 Suppl 1:S57-S59. Epub 2016 Dec 14.

Health Research Institute, Diabetes Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, 61357-15794, Iran. Electronic address:

The aim of current study was to evaluate the function of thyroid during diabetic acidosis, just after the treatment and two weeks after the treatment. This was the analytic study. The study subjects included 20 patients, aged 18-36 years old, with type1 diabetes and diabetic ketoacidosis. Read More

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http://dx.doi.org/10.1016/j.dsx.2016.12.001DOI Listing
November 2017
7 Reads

Usefulness of Serum Triiodothyronine (T3) to Predict Outcomes in Patients Hospitalized With Acute Heart Failure.

Am J Cardiol 2017 02 16;119(4):599-603. Epub 2016 Nov 16.

Division of Endocrinology, Winthrop-University Hospital, Mineola, New York.

Thyroid hormone plays an important role in cardiac function. Low levels of serum triiodothyronine (T) due to nonthyroidal illness syndrome may have adverse effects in heart failure (HF). This study was designed to assess the ability of T to predict in-hospital outcomes in patients with acute HF. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029149163181
Publisher Site
http://dx.doi.org/10.1016/j.amjcard.2016.10.045DOI Listing
February 2017
9 Reads

Free T3 to free T4 ratio less than 2.0 suggests low T3 syndrome rather than central hypothyroidism from the age of two to eighteen years.

Endocr J 2017 Feb 22;64(2):213-219. Epub 2016 Dec 22.

Division of Endocrinology and Metabolism, Tokyo Metropolitan Children's Medical Center, Tokyo, Japan.

No serological cut-off exists to separate low T3 syndrome (LT) and central hypothyroidism (CH). The objective of this retrospective study was to propose such a cut-off. The first participant group comprised 52 patients from the age of six to twenty years. Read More

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http://dx.doi.org/10.1507/endocrj.EJ16-0169DOI Listing
February 2017
14 Reads

Thyroid abnormalities in term infants with fungal sepsis.

Rev Assoc Med Bras (1992) 2016 Sep;62(6):561-567

Full Professor of Intensive Care/Neonatology at FMUSP and Instituto da Criança, HC-FMUSP, São Paulo, SP, Brazil.

Objective:: To describe thyroid alterations in term newborns (TNB) with fungal sepsis during NICU hospitalization.

Method:: The study included six TNB that during the clinical and laboratory manifestations of sepsis with positive cultures for fungus showed changes in thyroid hormones, called low T3 syndrome and low T3-T4 syndrome. TNB that could present hormonal changes caused by disease as those born to mothers with thyroid disease, or who had perinatal asphyxia and major surgeries were excluded. Read More

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http://dx.doi.org/10.1590/1806-9282.62.06.561DOI Listing
September 2016
8 Reads

Non-thyroidal illness syndrome in patients with cardiovascular diseases: A systematic review and meta-analysis.

Int J Cardiol 2017 Jan 18;226:1-10. Epub 2016 Oct 18.

Department of Endocrinology, Jinshan Hospital of Fudan University, Shanghai 201508, China. Electronic address:

Background: Non-thyroidal illness syndrome (NTIS) is characterized by decreased serum triiodothyronine level without increased thyroid-stimulating hormone level during critical illness. The summary data on the prevalence of NTIS in cardiovascular patients are lacking, and its prognostic role in cardiovascular patients is also unclear.

Methods: We performed a systematic review and meta-analysis to comprehensively determine the prevalence and the prognostic role of NTIS in cardiovascular patients. Read More

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http://dx.doi.org/10.1016/j.ijcard.2016.10.039DOI Listing
January 2017
11 Reads

Low T3 syndrome in neuromyelitis optica spectrum disorder: Associations with disease activity and disability.

J Neurol Sci 2016 Nov 22;370:214-218. Epub 2016 Sep 22.

Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea; Neuroscience Center, Samsung Medical Center, Seoul, Republic of Korea. Electronic address:

Background: Neuromyelitis optica (NMO) sometimes coexists with serological marker-positive, non-organ-specific autoimmune disorders. We evaluated the prevalence of thyroid dysfunction and anti-thyroid antibodies in patients with NMO spectrum disorder (NMOSD) and investigated the associations between thyroid dysfunction/autoimmunity and clinical features of NMOSD.

Methods: Forty-nine NMOSD patients with anti-aquaporin-4 antibody and 392 age- and sex-matched healthy controls were included. Read More

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http://dx.doi.org/10.1016/j.jns.2016.09.039DOI Listing
November 2016
12 Reads

Thyroxine increases Serca2 and Ryr2 gene expression in heart failure rats with euthyroid sick syndrome.

Arch Endocrinol Metab 2016 Nov-Dec;60(6):582-586. Epub 2016 Oct 10.

Departamento de Clínica Médica, Unidade de Pesquisa Experimental (Unipex), Faculdade de Medicina de Botucatu, Universidade Estadual Paulista (Unesp), Botucatu, SP, Brasil.

Objective: The current study was aimed at analyzing sarcoplasmic reticulum Ca2+ ATPase (Serca2) and ryanodine receptor type 2 (Ryr2) gene expression in rats subjected to surgery that induced HF and were subsequently treated with T4 using physiological doses.

Materials And Methods: HF was induced in 18 male Wistar rats by clipping the ascending thoracic aorta to generate aortic stenosis (HFS group), while the control group (9-sham) underwent thoracotomy. After 21 weeks, the HFS group was subdivided into two subgroups. Read More

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http://dx.doi.org/10.1590/2359-3997000000208DOI Listing
August 2017
10 Reads

Abnormal thyroid hormones and non-thyroidal illness syndrome in obstructive sleep apnea, and effects of CPAP treatment.

Sleep Med 2016 07 25;23:21-25. Epub 2016 Jul 25.

Institute of Biomedicine and Molecular Immunology, National Research Council, Palermo, Italy. Electronic address:

Objective: In obstructive sleep apnea (OSA), while both hypothyroidism and hyperthyroidism have been studied, the occurrence of non-thyroidal illness syndrome (NTIS) (normal thyroid stimulating hormone [TSH] with low triiodotironine) has not been investigated. We explored the occurrence of NTIS in patients with moderate to severe OSA and its relationship to the severity of nocturnal respiratory disorders. We also studied the occurrence of subclinical hypothyroidism (SH, ie, high TSH with normal thyroxine) in OSA and changes in circulating TSH, free triiodotironine (fT3) and free thyroxine (fT4) after CPAP treatment. Read More

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http://dx.doi.org/10.1016/j.sleep.2016.07.002DOI Listing
July 2016
15 Reads

Thyroid function in multidrug-resistant tuberculosis patients with or without human immunodeficiency virus (HIV) infection before commencement of MDR-TB drug regimen.

Afr Health Sci 2016 Jun;16(2):596-602

Deaprtment of Chemical Pathology, University of Ibadan/University College Hospital, Ibadan, Nigeria.

Background: Mycobacterium tuberculosis and human immunodeficiency virus (HIV) are known to cause abnormal thyroid function. There is little information on whether HIV infection aggravates alteration of thyroid function in patients with MDR-TB.

Objectives: This study was carried out to determine if HIV co-infection alters serum levels of thyroid hormones (T3, T4) and thyroid stimulating hormone (TSH) in patients with MDR-TB patients and to find out the frequency of subclinical thyroid dysfunction before the commencement of MDR-TB therapy. Read More

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http://dx.doi.org/10.4314/ahs.v16i2.30DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4994562PMC
June 2016
23 Reads

Treatment for non-thyroidal illness syndrome in advanced chronic kidney disease: a single-blind controlled study.

J Nephrol 2017 Aug 2;30(4):557-565. Epub 2016 Aug 2.

Department of Nephrology, The Second Affiliated Hospital of Nanchang University, 1, Minde Road, Nanchang, 330006, People's Republic of China.

Aim: Non-thyroidal illness syndrome (NTIS) is common among patients with advanced chronic kidney disease (CKD) and is strongly associated with poor prognosis. However, it remains unclear in how to correct this disorder and this study aimed to evaluate the effectiveness of sodium bicarbonate (SB) and N-acetyl-cysteine (NAC) for correcting NTIS status.

Methods: Patients with CKD stage 3-4 were single-blind, placebo-controlled treated with placebo, SB, or NAC for 18 weeks. Read More

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http://link.springer.com/10.1007/s40620-016-0341-2
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http://dx.doi.org/10.1007/s40620-016-0341-2DOI Listing
August 2017
19 Reads

[The relation between the low T3 syndrome in the clinical course of myocardial infarction and heart failure].

Pol Merkur Lekarski 2016 Jun;40(240):380-3

Jagiellonian University Medical College, Krakow, Poland, John Paul II Hospital: Department of Coronary Disease and Heart Failure.

It has been proven that either excess or deficiency of thyroid hormones has harmful influence on the cardiovascular system function. On the other hand, severe systemic conditions like myocardial infarction or severe heart failure may affect thyroid hormones secretion and their peripheral conversion, leading to low T3 syndrome. Amongst many mechanisms causing T4 to T3 conversion disturbances, important role plays decreased activity of D1 deiodinase and increased activity of D3 deiodinase. Read More

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June 2016
5 Reads

Thyroid hormone: relevance to xenotransplantation.

Xenotransplantation 2016 07 4;23(4):293-9. Epub 2016 Jul 4.

Thomas E Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA, USA.

Background: It has been well documented that the level of serum/plasma free triiodothyronine (fT3) falls rapidly following brain death or during certain surgical procedures, for example, heart surgery carried out on cardiopulmonary bypass. The level in patients following cardiopulmonary bypass usually recovers within 2 days.

Methods: We have measured serum fT3 in healthy naïve baboons (n = 31), healthy naïve monkeys (n = 5), and after pig-to-baboon heterotopic heart xenotransplantation (xenoTx) (Group 1, n = 9), orthotopic liver xenoTx (Group 2, n = 10), artery patch xenoTx (Group 3, n = 9), and in monkey-to-monkey heterotopic heart alloTx (Group 4, n = 5). Read More

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http://dx.doi.org/10.1111/xen.12243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4988877PMC
July 2016
18 Reads

SEVERE AMIODARONE-INDUCED BRADICARDIA CONCEALES SICK SINUS SYNDROME: CASE REPORT.

Rev Med Chir Soc Med Nat Iasi 2016 Jan-Mar;120(1):110-3

Sinus node dysfunction is one of the most common arrhythmias in elderly patients; it is usually associated with intermittent and variable symptoms, thus making it difficult to diagnose. We present the case of an elderly female patient with a personal history of atrial fibrillation treated for the last three years with amiodarone; she was admitted to the Geriatric Clinic for non-specific symptoms with onset two months previously for which she had already sought care in different medical services. Clinical examination showed severe bradycardia; ECG and Holter ECG on admission confirmed severe bradycardia, with a heart rate between 29 and 50 beats/min (bpm). Read More

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June 2016
6 Reads

Euthyroid Sick Syndrome.

Compr Physiol 2016 Mar 15;6(2):1071-80. Epub 2016 Mar 15.

Section of Endocrinology, Diabetes and Nutrition, Department of Medicine, Boston University School of Medicine, Boston Medical Center, Boston, Massachusetts, USA.

In this review, we discuss the characteristics, pathophysiology, and therapeutic implications of the euthyroid sick syndrome. Multiple mechanisms have been identified to contribute to the development of euthyroid sick syndrome, including alterations in the iodothyronine deiodinases, thyroid-stimulating hormone secretion, thyroid hormone binding to plasma protein, transport of thyroid hormone in peripheral tissues, and thyroid hormone receptor activity. The euthyroid sick syndrome appears to be a complex mix of physiologic adaptation and pathologic response to acute illness. Read More

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http://doi.wiley.com/10.1002/cphy.c150017
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http://dx.doi.org/10.1002/cphy.c150017DOI Listing
March 2016
8 Reads