10,446 results match your criteria Euthyroid Hyperthyroxinemia


Clinical efficacy of transcutaneous triamcinolone acetonide injection for upper eyelid retraction and swelling in patients with thyroid eye disease.

Int Med Case Rep J 2018 9;11:325-331. Epub 2018 Nov 9.

Olympia Eye Hospital, Tokyo, Japan,

Aim: To evaluate the efficacy of transcutaneous triamcinolone acetonide (TA) injection for the treatment of upper eyelid retraction and swelling in thyroid eye disease (TED) patients.

Patients And Methods: This is a case series. Three euthyroid TED patients with features of both upper eyelid retraction and swelling were recruited. Read More

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November 2018

Percutaneous laser ablation of benign thyroid nodules: a one year follow-up study.

Einstein (Sao Paulo) 2018 Nov 29;16(4):eAO4279. Epub 2018 Nov 29.

Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.

Objective: To evaluate safety and effectiveness of nodule volume reduction and thyroid function after percutaneous laser ablation treatment in patients with benign nonfunctioning thyroid nodules.

Methods: Prospective single-center study, from January 2011 to October 2012, which evaluated 30 euthyroid and thyroid antibodies negative patients with benign solitary or dominant nodule with indication of treatment due to compressive symptoms and aesthetic disturbances. The clinical and laboratory (thyroid ultrasound, TSH, FT4, TG, TG-Ab, TPO-Ab and TRAb levels) evaluations were performed before the procedure, and periodically 1 week, 3 months and 6 months after. Read More

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November 2018
1 Read

Plasma endothelin-1 levels are increased in atrial fibrillation patients with hyperthyroidism.

PLoS One 2018 4;13(12):e0208206. Epub 2018 Dec 4.

Department of Molecular Cardiology, Cleveland Clinic, Ohio, United States of America.

Background: Endothelin-1 (ET-1) is a potent vasoconstrictor, mitogen and inflammatory factor that may contribute to development of atrial fibrillation (AF). Plasma ET-1 levels are increased in hyperthyroid patients, but studies evaluating its relation to AF development in hyperthyroid patients are lacking.

Objective: The present study seeks to evaluate the relation of plasma ET-1 to AF development as a function of thyroid status. Read More

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December 2018
1 Read

Total tiroidectomy in patient with McArdle's syndrome: Anesthetic management.

Rev Esp Anestesiol Reanim 2018 Nov 30. Epub 2018 Nov 30.

Servicio de Anestesiología y Reanimación, Hospital de Jerez de la Frontera, Jerez de la Frontera (Cádiz), España.

McArdle disease or type V glycogenosis is a rare metabolic myopathy consisting of muscle loss and weakness. These patients have risks associated with anaesthesia. They can present with hypoglycaemia, rhabdomyolysis, acute renal failure, and electrolyte changes. Read More

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November 2018
1 Read

Practice Variance in Thyroid Screening of Youth with Type 1 Diabetes Mellitus.

Horm Res Paediatr 2018 Nov 29:1-4. Epub 2018 Nov 29.

Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.

Background: Variance between current American Diabetes Association (ADA) and International Society for Pediatric and Adolescent Diabetes (ISPAD) guidelines and in clinical practice exists for the use of thyroid antibody and thyroid function screening in pediatric patients with new-onset type 1 diabetes (T1D).

Methods: North American Pediatric Endocrine Society (PES) members were surveyed regarding their thyroid screening practices of euthyroid youth with T1D. An institutional analysis of the ability of antithyroid peroxidase (aTPO) and antithyroglobulin antibodies (aTG) to predict the subsequent use of levothyroxine was performed. Read More

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November 2018
2 Reads

Rapid Relief: Thyroidectomy is a Quicker Cure than Radioactive Iodine Ablation (RAI) in Patients with Hyperthyroidism.

World J Surg 2018 Nov 27. Epub 2018 Nov 27.

Division of Endocrine Surgery, Department of Surgery, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., E6.104B, Dallas, TX, 75390-9092, USA.

Background: Time to hormonal control after definitive management of hyperthyroidism is unknown but may influence patient and physician decision making when choosing between treatment options. The hypothesis is that the euthyroid state is achieved faster after thyroidectomy than RAI ablation.

Methods: A retrospective review of all patients undergoing definitive therapy for hyperthyroidism was performed. Read More

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November 2018

Evaluation of redox profiles in exogenous subclinical hyperthyroidism at two different levels of TSH suppression.

Arch Endocrinol Metab 2018 Oct;62(5):545-551

Departamento de Endocrinologia, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brasil.

Objective: Evaluate the relationship between exogenous subclinical hyperthyroidism and oxidative stress through the analysis of the redox profile of patients with subclinical hyperthyroidism exogenous (SCH) grade I (TSH = 0.1 to 0.4 IU/mL) and grade II (TSH < 0. Read More

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October 2018
1 Read

Exercise training improves quality of life in women with subclinical hypothyroidism: a randomized clinical trial.

Arch Endocrinol Metab 2018 Oct;62(5):530-536

Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brasil.

Objective: The aim was to evaluate the quality of life (HRQoL) in women with subclinical hypothyroidism (sHT) after 16 weeks of endurance training.

Subjects And Methods: In the first phase, a cross-sectional study was conducted in which 22 women with sHT (median age: 41.5 (interquartile range: 175) years, body mass index: 26. Read More

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October 2018
1 Read

Adipose TSHB in Humans and Serum TSH in Hypothyroid Rats Inform About Cellular Senescence.

Cell Physiol Biochem 2018 16;51(1):142-153. Epub 2018 Nov 16.

Department of Diabetes, Endocrinology and Nutrition Institut d'Investigació Biomèdica de Girona (IdIBGi), CIBEROBN (CB06/03/010) and Instituto de Salud Carlos III (ISCIII), Girona, Spain.

Background/aims: Thyroid hormones have been recently linked to senescence and longevity. Given the recent description of TSHB mRNA in human adipose tissue (AT), we aimed to investigate the relationship between local AT TSH and adipose tissue senescence.

Methods: TSHB mRNA (measured by real-time PCR) and markers of adipose tissue senescence [BAX, DBC1, TP53, TNF (real-time PCR), telomere length (Telo TAGGG Telomere Length Assay) and lipidomics (liquid chromatography mass spectrometry)] were analysed in subcutaneous (SAT) and visceral (VAT) AT from euthyroid subjects. Read More

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November 2018

Thyroid-stimulating hormone within the normal range and risk of major adverse cardiovascular events in non-ischemic dilated cardiomyopathy patients with severe left ventricular dysfunction.

Clin Cardiol 2018 Nov 17. Epub 2018 Nov 17.

State Key Laboratory of Cardiovascular Disease, Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College.

Background: The association between thyroid-stimulating-hormone(TSH) and prognosis of nonischemic dilated cardiomyopathy(NIDCM) in patients with normal thyroid function remains unclear.

Objective: The present study investigated whether TSH is associated with major adverse cardiovascular events in euthyroid NIDCM patients.

Methods: The original cohort consisted of 216 consecutive euthyroid NIDCM patients, with left ventricular ejection fraction(LVEF) ≤ 35%, who were observed from 2010 to 2013. Read More

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November 2018
2 Reads

Serum levels of fetuin-A are negatively associated with log transformation levels of thyroid-stimulating hormone in patients with hyperthyroidism or euthyroidism: An observational study at a medical center in Taiwan.

Medicine (Baltimore) 2018 Nov;97(46):e13254

Department of Internal Medicine, National Taiwan University Hospital, and National Taiwan University College of Medicine.

Fetuin-A is a protein with various biological functions. It plays a role in insulin resistance and arterial calcium deposition. Thyroid dysfunction may affect energy expenditure, glucose metabolism, and the risk of cardiovascular diseases. Read More

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November 2018
4 Reads

Pituitary 18F-FDG uptake correlates with serum TSH levels in thyroid cancer patients on 18F-FDG PET/CT.

Nucl Med Commun 2019 Jan;40(1):57-62

Department of Nuclear Medicine, XinHua Hospital, School of Medicine, Shanghai Jiaotong University.

Objective: The objective of this study was to evaluate the relationship between fluorine-18-fluorodeoxyglucose (F-FDG) uptake in the pituitary gland and serum thyroid-stimulating hormone (TSH) levels in differentiated thyroid cancer (DTC) patients on F-FDG PET/computed tomography (CT).

Patients And Methods: A total of 215 DTC patients and 215 age-paired and sex-paired healthy screening participants were included. DTC patients were divided into hypothyroid, euthyroid and subclinical hyperthyroid patients according to their serum TSH levels. Read More

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January 2019
6 Reads

Tc-pertechnetate thyroid scintigraphy predicts clinical outcomes in personalized radioiodine treatment for Graves' disease.

Rev Esp Med Nucl Imagen Mol 2018 Nov - Dec;37(6):349-353. Epub 2018 Nov 6.

Department of Nuclear Medicine, China-Japan Union Hospital of Jilin University, Changchun, Jilin, PR China. Electronic address:

Objective: The aim of this study was, first, to ascertain the efficacy of radioiodine therapy (RIT) for Graves' disease (GD) based on a calculated-dose regime and, second, to determine the value of Tc-pertechnetate thyroid scintigraphy in predicting the clinical outcomes of RIT.

Methods: One hundred and thirty 9consecutive GD patients who underwent RIT using a calculated-dose method in our hospital from January 2015 to September 2015 were retrospectively evaluated. Radioiodine dose was calculated based on the Marinelli's formula. Read More

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November 2018
6 Reads

The optimal dosing scheme for levothyroxine after thyroidectomy: A comprehensive comparison and evaluation.

Surgery 2018 Nov 6. Epub 2018 Nov 6.

Department of Surgery, University of Wisconsin, Madison, WI.

Background: Patients often struggle to attain euthyroidism after thyroidectomy, and multiple dosing schemes have been proposed to supplant the standard weight-based approach for initial levothyroxine dosing after thyroidectomy. The objectives of this study were to review the literature for existing levothyroxine dosing schemes and compare estimation accuracies with novel schemes developed with machine learning.

Methods: This study retrospectively analyzed 598 patients who attained euthyroidism after total or completion thyroidectomy for benign disease. Read More

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November 2018

Effects of short term hypothyroidism on the lipid transfer to HDL and other parameters related to lipoprotein metabolism in patients submitted to thyroidectomy for thyroid cancer.

Thyroid 2018 Nov 9. Epub 2018 Nov 9.

Heart Institute of Medical School Hospital, University of Sao Paulo , Av Dr Enéas de Carvalho Aguiar, 44, 1°subsolo, lab 26, CEP 05423-000 , São Paulo, São Paulo, Brazil , 05423-000 ;

Background: Elevation of LDL-cholesterol is the hallmark of hypothyroidism dyslipidemia, but alterations on HDL plasma levels and metabolism are less understood. The aim of this study was to explore aspects of HDL metabolism and enzymes that act on HDL after a short period of overt hypothyroidism.

Methods: Eighteen women (44±11 years, BMI 27. Read More

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November 2018
2 Reads

Acute Thyroid Storm Following Thymectomy: A Surprising Result of Undiagnosed Graves' Disease.

Cureus 2018 Aug 31;10(8):e3239. Epub 2018 Aug 31.

Surgery, University of Texas Medical Branch, Galveston, USA.

Postoperative thyroid storm represents a diagnostic dilemma in patients with overlooked hyperthyroid state undergoing a nonthyroid surgery. We report a 30-year-old female with a history of mixed connective tissue disease who presented with an anterior mediastinal mass and underwent a thoracoscopic resection of the mass. On postoperative day 1, she had an acute change in mental status with fever, tachycardia and hypercapnic respiratory failure requiring intubation and mechanical ventilation. Read More

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August 2018
4 Reads

Thyroid hormones, metabolic syndrome and Vitamin D in middle-aged and older euthyroid subjects: a preliminary study.

Aging Clin Exp Res 2018 Nov 7. Epub 2018 Nov 7.

Division of Gerontology, Department of Cardiovascular, Respiratory, Nephrological, Anesthesiological and Geriatric Sciences, Sapienza University of Rome, Viale del Policlinico 155, 00161, Rome, Italy.

Aim: To explore the relationship between thyroid hormones, Vitamin D (Vit.D) serum concentrations and metabolic syndrome (MetS) in euthyroid subjects.

Methods: 123 community-dwelling subjects were enrolled. Read More

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November 2018
1.140 Impact Factor

A dosimetric study on radiation-induced hypothyroidism following intensity-modulated radiotherapy in patients with nasopharyngeal carcinoma.

Oncol Lett 2018 Nov 20;16(5):6126-6132. Epub 2018 Aug 20.

Department of Radiation Oncology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221006, P.R. China.

The objective of the present study was to investigate the association between thyroid gland-dosimetric parameters and hypothyroidism induced by intensity-modulated radiotherapy in patients with nasopharyngeal carcinoma (NPC). A total of 52 patients with NPC treated in the Department of Radiation Oncology of The Affiliated Hospital of Xuzhou Medical University, from May 2008 to December 2016 were retrospectively enrolled in the present study and divided into two groups based on thyroid function: The euthyroid and hypothyroid groups. The association between hypothyroidism and clinical or dosimetric parameters were analyzed. Read More

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November 2018

Can Panax Ginseng protect against fertility disorders in hypothyroid female albino rats?

Cell Mol Biol (Noisy-le-grand) 2018 Oct 30;64(13):97-102. Epub 2018 Oct 30.

Faculty of Medicine, Taibah university, KSA.

Hypothyroidism is an endocrine disorder due to decreased thyroid hormone production. This endocrine disorder significantly affects the menstrual cycle and fertility. The aim of this present study was to assess the efficacy of Panax ginseng, one of traditional Chinese medicine, in ameliorating the gonadal hormonal dysfunction and lowering oxidative stress accompanied with hypothyroidism in adult female albino rats. Read More

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October 2018
9 Reads

The Krakow Declaration: The last chance for Europe to eradicate iodine deficiency.

Endocrinol Diabetes Nutr 2018 Dec 3;65(10):553-555. Epub 2018 Nov 3.

Servicio de Endocrinología y Nutrición, Hospital Germans Trias i Pujol, Institut de Recerca Germans Trias i Pujol (IGTP), Badalona, Barcelona, España; Área de conocimiento de la Tiroides, grupo de Nutrición de Yodo, Sociedad Española de Endocrinología y Nutrición (SEEN), proyecto EUthyroid (Towards the elimination of iodine deficiency and preventable thyroid-related diseases in Europe - Horizon 2020).

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December 2018
1 Read

Levothyroxine Therapy Achieves Physiological FT3/FT4 Ratios at Higher than Normal TSH Levels: A Novel Justification for T3 Supplementation?

Horm Metab Res 2018 Nov 5;50(11):827-831. Epub 2018 Nov 5.

Department of Pediatrics, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.

In euthyroidism, as thyroid Stimulating hormone (TSH) levels increase, the free triiodothyronine (FT3) to free thyroxine (FT4) ratio increases. The aim of this study was to assess if beyond the euthyroid range of TSH levels FT3/FT4 ratio continues to increase and if levothyroxine treatment reduces this ratio, possibly through TSH suppression. This cross sectional retrospective study included a total of 77 832 patients [age 22. Read More

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November 2018
5 Reads

High-normal thyroid-stimulating hormone in euthyroid subjects is associated with risk of mortality and composite disease endpoint only in women.

Arch Med Sci 2018 Oct 26;14(6):1394-1403. Epub 2016 Oct 26.

Department of Cardiology, Suruç State Hospital, Şanliurfa, Turkey.

Introduction: The aim of the study was to evaluate whether serum thyroid-stimulating hormone (TSH) within the normal range in euthyroid subjects (having normal free triiodothyronine (fT3) and thyroxine (fT4)) is related to the risk of overall mortality or a composite endpoint of death and nonfatal events.

Material And Methods: In 614 middle-aged adult hospital screenees, free of uncontrolled diabetes at baseline, the association of sex-specific TSH tertiles with death was prospectively assessed using Cox regression, with the composite endpoint assessed using logistic regression in adjusted analyses, stratified by gender.

Results: In total, 64 deaths and additional incident nonfatal events in 141 cases were recorded at a mean 7. Read More

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October 2018
3 Reads

[Clinical observation of thyroid-related adverse events induced by anti-PD-1 antibody SHR-1210 in patients with advanced solid tumor].

Zhonghua Zhong Liu Za Zhi 2018 Oct;40(10):772-775

Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

To assess the incidence and characteristics of thyroid dysfunction during anti-Programmed cell death 1 receptor (PD-1) antibody SHR-1210 therapy in patients with advanced solid tumor. The medical records of 98 patients who initiated SHR-1210 treatment between April 27, 2016 and June 8, 2017 in the phase 1 trial to evaluate the safety, efficacy, and pharmacokinetics of SHR-1210 in patients with advanced solid tumors were retrospectively reviewed. Serological tests of thyroid stimulating hormone (TSH) and free thyroxine (fT4) were measured at baseline and prior to each SHR-1210 administration. Read More

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October 2018
6 Reads

[CME: Thyrotoxicosis and Thyroiditis].

Authors:
Lea Slahor

Praxis (Bern 1994) 2018;107(22):1187-1192

1 Endokrinologie/Diabetologie, Luzerner Kantonsspital, Luzern.

Hyperthyroidism is caused by an increased synthesis of thyroid hormones or release of preformed thyroid hormones due to destruction of thyroid tissue, or there is an exogenous extrathyroidal source. The term thyroiditis describes a heterogeneous group of disorders, which result in destruction of thyroid tissue and release of preformed thyroid hormones. Although a less common condition, a thyroiditis remains an important differential diagnosis for thyrotoxicosis, and a symptomatic therapy is the cornerstone of treatment. Read More

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January 2018
3 Reads

Adequate restitution in primary hypothyroidism depending on levothyroxine formulations

Rev Med Inst Mex Seguro Soc 2018 Oct 25;56(3):255-260. Epub 2018 Oct 25.

Universidad Autónoma de Nuevo León, Facultad de Medicina, Subdirección de Investigación. Monterrey, Nuevo León, México

Background: The prevalence of primary hypothyroidism (PH) is around 3.8%-4.6% in general population. Read More

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October 2018
2 Reads

Hashimoto's thyroiditis induces neuroinflammation and emotional alterations in euthyroid mice.

J Neuroinflammation 2018 Oct 29;15(1):299. Epub 2018 Oct 29.

Department of Endocrinology, Anhui Geriatric Institute, the First Affiliated Hospital of Anhui Medical University, Hefei, 230032, China.

Background: Although studies have reported an increased risk for mood disorders in Hashimoto's thyroiditis (HT) patients even in the euthyroid state, the mechanisms involved remain unclear. Neuroinflammation may play a key role in the etiology of mood disorders in humans and behavioral disturbances in rodents. Therefore, this study established a euthyroid HT model in mice and investigated whether HT itself was capable of triggering neuroinflammation accompanied by emotional alterations. Read More

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October 2018
9 Reads
5.410 Impact Factor

Association of thyroid function with sarcopenia in elderly Chinese euthyroid subjects.

Aging Clin Exp Res 2018 Oct 26. Epub 2018 Oct 26.

Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, People's Republic of China.

Objectives: With the increase in aging population worldwide, the incidence of sarcopenia is also increasing. Thyroid hormones are important regulators that can affect body composition and physical function. The association between thyroid hormone levels and sarcopenia in susceptible elderly euthyroid subjects remains unclear. Read More

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October 2018
4 Reads
1.140 Impact Factor

Vitamin D Deficiency and Immune Disorders in Combined Endocrine Pathology.

Front Endocrinol (Lausanne) 2018 9;9:600. Epub 2018 Oct 9.

Endocrinology Department, Bogomolets National Medical University, Kyiv, Ukraine.

Combined endocrine pathology is a serious healthcare problem in Ukraine. This prospective study assessed the blood levels of 25-hydroxyvitamin D [25(OH)D] and markers of immune function in response to vitamin D intervention in patients with type 1 and type 2 diabetes mellitus (T1DM and T2DM, respectively) and autoimmune thyroiditis (AIT). This study evaluated the relationship between the metabolic and immune status of DM + AIT patients with respect to their vitamin D status and changes after vitamin D supplementation. Read More

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October 2018
1 Read

Atorvastatin potentiates the effect of selenomethionine on thyroid autoimmunity in euthyroid women with Hashimoto's thyroiditis.

Curr Med Res Opin 2018 Oct 25:1-7. Epub 2018 Oct 25.

a Department of Internal Medicine and Clinical Pharmacology , Medical University of Silesia , Katowice , Poland.

Objective: In many studies, selenium supplementation decreased serum titers of thyroid antibodies. The aim of the study was to investigate whether statin therapy determines selenium action on thyroid autoimmunity.

Methods: This prospective case-control study enrolled 42 euthyroid women with Hashimoto's thyroiditis and normal vitamin D status, 20 of whom had been treated with atorvastatin (40 mg daily) for at least 6 months. Read More

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October 2018
3 Reads

Levothyroxine Replacement Therapy and Overuse: A Timely Diagnostic Approach.

Thyroid 2018 Nov 30. Epub 2018 Nov 30.

3 Endocrine Unit, Evgenidion Hospital, University of Athens , Athens, Greece .

Background: Levothyroxine (LT4) is one of the most prescribed drugs worldwide. Once started, approximately 90% of patients continue treatment long term. However, accumulating evidence suggests that many patients, for whom the indication for its administration is not adequately established and the diagnosis is not well documented, are overusing it. Read More

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November 2018

Longitudinal characterization of autoantibodies to the thyrotropin receptor (TRAb) during alemtuzumab therapy; evidence that TRAb may precede thyroid dysfunction by many years.

Thyroid 2018 Oct 23. Epub 2018 Oct 23.

Cardiff University - School of Medicine, Division of Infection & Immunity - Thyroid Research Group, Cardiff, United Kingdom of Great Britain and Northern Ireland ;

BACKGROUND Thyroid autoimmunity, especially Graves' disease or hypothyroidism with positive autoantibodies (TRAb) to the thyrotropin receptor (TSHR), occurs in 30-40% of patients with relapsing multiple sclerosis (MS) following treatment with alemtuzumab (ALTZ). ALTZ therapy therefore provides a unique opportunity to study the evolution of TRAb prior to clinical presentation. TRAb can stimulate (TSAb), block (TBAb) or not affect ("neutral": TNAb) the TSHR function, causing hyperthyroidism, hypothyroidism or euthyroidism, respectively. Read More

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October 2018
7 Reads
4.490 Impact Factor

Outcome of radioactive iodine therapy in Toxic Nodular Goiter in Pakistan.

Pak J Med Sci 2018 Sep-Oct;34(5):1146-1151

Muhammad Areeb Ashfaq, Medical Student, Aga Khan University Hospital, Karachi, Pakistan.

Objective: To determine the outcome of patients receiving radioactive iodine therapy for toxic nodular goiter coming to Aga Khan University Hospital Karachi.

Methods: A total of 89 patients who visited the outpatient department of Aga Khan University Hospital from January 2010 to August 2017 were recruited for the study. Toxic nodular goiter was diagnosed on the basis of having hot nodule on thyroid scan with low TSH and high FT4/T4. Read More

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October 2018
6 Reads

The relationship between resting energy expenditure and thyroid hormones in response to short-term weight loss in severe obesity.

PLoS One 2018 19;13(10):e0205293. Epub 2018 Oct 19.

IRCCS Istituto Auxologico Italiano, Division of Metabolic Diseases, Piancavallo, Verbania, Italy.

Background: Regulating thermogenesis is a major task of thyroid hormones (THs), and involves TH-responsive energetic processes at the central and peripheral level. In severe obesity, little is known on the relationship between THs and resting energy expenditure (REE) before and after weight loss.

Methods: We enrolled 100 euthyroid subjects with severe obesity who were equally distributed between genders. Read More

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October 2018

Relationship between total thyroxine, thyroid palpation and a clinical index in hyperthyroid and healthy cats and cats with other diseases.

J Feline Med Surg 2018 Oct 17:1098612X18799462. Epub 2018 Oct 17.

Center of Clinical Veterinary Medicine, Clinic of Small Animal Medicine, Ludwig Maximilian University, Munich, Germany.

Objectives Present-day diagnosis of hyperthyroidism is often established in the early stages where clinical signs and physical examination findings typically associated with the disease may not yet be present. The purpose of this study was to investigate thyroid palpation score (TPS), total thyroxine (T4), body weight, body condition score and a clinical scoring index, which assesses severity of illness and quality of life, in untreated hyperthyroid cats, healthy cats and cats with non-thyroidal illness. Methods Fifty-five cats with hyperthyroidism, 45 healthy cats and 327 euthyroid cats with non-thyroidal disease were prospectively enrolled. Read More

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October 2018
4 Reads

Investigation of a novel variable dosing protocol for radioiodine treatment of feline hyperthyroidism.

J Vet Intern Med 2018 Nov 17;32(6):1856-1863. Epub 2018 Oct 17.

Department of Small Animal Clinical Sciences, Virginia-Maryland College of Veterinary Medicine, Blacksburg, Virginia.

Background: Radioiodine is the treatment of choice for hyperthyroidism in cats. The ideal method of dose determination of radioiodine remains controversial.

Objective: To compare a method of radioiodine dose determination that utilized thyroid scintigraphy with a standard fixed dose for treatment of hyperthyroidism. Read More

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November 2018
1 Read

Subclinical Hypothyroidism and Coronary Revascularization After Coronary Artery Bypass Grafting.

Am J Cardiol 2018 Dec 7;122(11):1862-1870. Epub 2018 Sep 7.

Department of Thoracic and Cardiovascular Surgery, Seoul National University Bundang Hospital, Seongnam, Republic of Korea. Electronic address:

We aimed to investigate long-term cardiovascular sequelae after coronary artery bypass grafting (CABG) in patients with subclinical hypothyroidism (SCH). All-cause and cardiovascular-related mortality, and cardiovascular events were retrospectively reviewed in 222 euthyroid and 36 SCH patients who underwent CABG. During a mean follow-up period of 8. Read More

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December 2018
3 Reads

Thyroid dysfunction in children with leukemia over the first year after hematopoietic stem cell transplantation.

J Pediatr Endocrinol Metab 2018 Nov;31(11):1241-1247

Department of Pediatrics, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea.

Background Thyroid function in children with leukemia during the first year after hematopoietic stem cell transplantation (HSCT) was investigated. Methods The medical records of 186 subjects [111 boys and 75 girls; lymphoid=75, myeloid=111; median age at HSCT was 10.7 (0. Read More

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November 2018
1 Read
0.710 Impact Factor

Validation of Billewicz Scoring System for Detection of Overt Hypothyroidism During Pregnancy.

Int J Endocrinol Metab 2018 Jul 7;16(3):e64249. Epub 2018 Jul 7.

Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran.

Background: Currently, various clinical and laboratory diagnostic methods are used to detect overt hypothyroidism during pregnancy. The Billewicz scoring index, as a clinical scale for detection of hypothyroidism, has been applied in general populations; however, its application during pregnancy remains a controversial subject of ongoing research.

Objectives: The purpose of this study was to evaluate the diagnostic value of Billewicz scoring index for overt hypothyroidism in a general population of Iranian pregnant women. Read More

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July 2018
10 Reads

The effect of levothyroxine treatment on left ventricular function in subclinical hypothyroidism.

Arch Endocrinol Metab 2018 Aug;62(4):392-398

University Clinic of Cardiology, Medical Faculty, Skopje, R. Macedonia.

Objective: Treatment of subclinical hypothyroidism (ScH), especially the mild form of ScH, is controversial because thyroid hormones influence cardiac function. We investigate left ventricular systolic and diastolic function in ScH and evaluate the effect of 5-month levothyroxine treatment.

Subjects And Methods: Fifty-four patients with newly diagnosed mild ScH (4. Read More

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August 2018
3 Reads

The effect of obesity and dietary habits on oxidative stress in Hashimoto’s thyroiditis

Endocr Connect 2018 Sep 1;7(9):990-997. Epub 2018 Sep 1.

Objective: Increased oxidative stress has been described in patients with Hashimoto’s thyroiditis (HT). The aim of the present study was to investigate whether high oxidative stress is further influenced by obesity and dietary habits in euthyroid women with HT.

Methods: Two hundred eighteen consecutive euthyroid women with HT were studied and separated in two groups; 102 with thyroxine replacement and 114 without. Read More

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September 2018
1 Read

Fetal hyperthyroidism associated with maternal thyroid autoantibodies: A case report.

Case Rep Womens Health 2018 Oct 26;20:e00081. Epub 2018 Sep 26.

Department of Endocrinology and Diabetes, "Alexandra" Hospital, Athens, Greece.

A 33-year-old Caucasian woman was referred at 24 + 3 weeks of gestation due to fetal tachycardia and hydrops. She had an uncomplicated pregnancy 16 years previously and was on levothyroxine after total thyroidectomy for Graves' disease 6 years previously, when she developed moderate exophthalmos. Laboratory evaluation revealed appropriate thyroid function for this time of gestation: thyroid stimulating hormone (TSH) 1. Read More

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October 2018
11 Reads

Encapsulated Follicular Variant of Papillary Thyroid Carcinoma Arising in a Follicular Adenoma: a Diagnostic Dilemma.

Indian J Surg Oncol 2018 Sep 13;9(3):414-417. Epub 2018 Aug 13.

2Department of ENT, ESIC Medical College, Faridabad, Haryana India.

Papillary thyroid carcinoma (PTC) arising within follicular adenoma is a rare histological subset of papillary carcinoma. A 24-year-old female (euthyroid and asymptomatic) presented with a solitary mass in the right lobe of thyroid for 2 years. Fine-needle aspiration cytology (FNAC) suggested features of hyperplasia of thyroid. Read More

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September 2018
2 Reads

The Krakow Declaration on Iodine: Tasks and Responsibilities for Prevention Programs Targeting Iodine Deficiency Disorders.

Authors:

Eur Thyroid J 2018 Aug 10;7(4):201-204. Epub 2018 Jul 10.

On April 18, 2018 the EUthyroid consortium released the Krakow Declaration on Iodine in response to the increasing concern about the deteriorating commitment of policymakers to address public health strategies against iodine deficiency disorders (IDD) in the European populations. Regulators and policymakers should harmonize obligatory Universal Salt Iodization to ensure free trade of fortified foodstuffs in Europe. Similarly, iodized animal feed requires regulatory approval to ensure free trade within the EU. Read More

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How Do We Improve the Impact of Iodine Deficiency Disorders Prevention in Europe and Beyond?

Eur Thyroid J 2018 Aug 31;7(4):193-200. Epub 2018 Jul 31.

Institute of Molecular Medicine, Cardiff University, Cardiff, United Kingdom.

Background: Iodine deficiency disorders (IDD) represent a global health threat to individuals and societies. IDD prevention programmes have been introduced in many parts of the world. However, challenges remain, particularly in Europe due to fragmentation and diversity of approaches that are not harmonized. Read More

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August 2018
1 Read

Thyroid Hemiagenesis in a Thyroiditis Prone Mouse Strain.

Eur Thyroid J 2018 Aug 18;7(4):187-192. Epub 2018 Jul 18.

Thyroid Autoimmune Disease Unit, Cedars-Sinai Research Institute, Los Angeles, California, USA.

Background: Thyroid hemiagenesis, a rare congenital condition detected by ultrasound screening of the neck, is usually not manifested clinically in humans. This condition has been reported in mice with hypothyroidism associated with induced deficiency in paired box 8 and NK2 homeobox 1, sonic hedgehog, or T-box 1. Unexpectedly, we observed thyroid hemiagenesis in NOD. Read More

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August 2018
2 Reads

Neutrophil- and Platelet- to Lymphocyte Ratio in Patients with Euthyroid Hashimoto's Thyroiditis.

Exp Clin Endocrinol Diabetes 2018 Sep 28. Epub 2018 Sep 28.

Okmeydani Research and Training Hospital, Internal Medicine Clinic, Istanbul, Turkey.

Background: Hashimoto's thyroiditis (HT) is the most prevalent autoimmune thyroid disorder. Both neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are reported to be increased in various inflammation-related diseases, but their clinical significance in HT remains unclear.

Objectives: The aim of this study was to investigate the relationship between thyroid autommunity and NLR and PLR as markers of systemic inflammation in HT. Read More

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September 2018
2 Reads

Iodine intake and chronic autoimmune thyroiditis: a comparative study between coastal and mainland regions in Greece.

Hormones (Athens) 2018 Sep 28. Epub 2018 Sep 28.

Laikon General Hospital, National and Kapodistrian University of Athens, Athens, Greece.

Introduction: The purpose of this study was to evaluate the relationship between iodine intake and autoimmune thyroiditis in Chios, an island located in the North East Aegean Sea, in comparison to mainland regions in South Western Greece (SWG).

Materials And Methods: Urine iodine concentration (UIC), thyroid function (serum TSH, thyroid autoantibodies: anti-TPO and anti-Tg), and thyroid U/S were assessed in 200 subjects (150 females and 50 males) from Chios and 322 subjects (255 females and 67 males) from several mainland regions in SWG. All participants were recruited from outpatient clinics and were diagnosed as euthyroid. Read More

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September 2018
5 Reads

Relationship between thyroid function and elevated blood pressure in euthyroid adults.

J Clin Hypertens (Greenwich) 2018 Oct 8;20(10):1541-1549. Epub 2018 Sep 8.

Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, China.

Thyroid hormones (THs) have profound effects on cardiovascular functions, suggesting that THs may contribute to the development of elevated blood pressure (BP). Few studies, however, have systematically assessed the relationship between THs and elevated BP. We therefore conducted a cross-sectional study to examine how serum THs concentrations are related to the prevalence of elevated BP in a euthyroid population. Read More

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October 2018
2 Reads

Phenomic Impact of Genetically-Determined Euthyroid Function and Molecular Differences between Thyroid Disorders.

J Clin Med 2018 Sep 21;7(10). Epub 2018 Sep 21.

Department of Psychiatry, Yale School of Medicine and VA CT Healthcare Center, West Haven, CT 06516, USA.

Background: The thyroid plays a key role in development and homeostasis, but it has been difficult to establish causality with diseases and phenotypic traits because of several potential confounders.

Methods: To determine the causal effect of euthyroid function, we conducted a two-sample Mendelian randomization study of euthyroid thyrotropin (TSH) and free thyroxine (FT4) levels with respect to 2419 traits assessed in 337,199 individuals from UK Biobank. Additionally, we investigated the molecular differences between hypothyroidism and hyperthyroidism using genome-wide data. Read More

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September 2018
1 Read

Changes in Serum Immunoglobulin G4 Levels in Patients with Newly Diagnosed Graves' Disease.

Exp Clin Endocrinol Diabetes 2018 Sep 20. Epub 2018 Sep 20.

Department of Endocrinology & Metabolism, Fujita Health University School of Medicine 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi, Japan.

Objective: Immunoglobulin G4 (IgG4)-related disease (IgG4-RD) is an immune-mediated condition that can affect almost any organ. We investigated the association between IgG4-RD and the main characteristics of Graves' disease (GD) at the time of diagnosis. Additionally, we evaluated whether serum IgG4 levels change during treatment. Read More

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September 2018
3 Reads