1 results match your criteria European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology[Journal]

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Cross-species evidence from human and rat brain transcriptome for growth factor signaling pathway dysregulation in major depression.

Neuropsychopharmacology 2018 09 12;43(10):2134-2145. Epub 2018 Jun 12.

Karolinska Institutet, Department of Clinical Neuroscience, Stockholm, Sweden.

An enhanced understanding of the pathophysiology of depression would facilitate the discovery of new efficacious medications. To this end, we examined hippocampal transcriptional changes in rat models of disease and in humans to identify common disease signatures by using a new algorithm for signature-based clustering of expression profiles. The tool identified a transcriptomic signature comprising 70 probesets able to discriminate depression models from controls in both Flinders Sensitive Line and Learned Helplessness animals. Read More

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http://dx.doi.org/10.1038/s41386-018-0117-6DOI Listing
September 2018
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