297,004 results match your criteria European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology[Journal]


Antibiotic pollution in surface fresh waters: Occurrence and effects.

Sci Total Environ 2019 Feb 5;664:793-804. Epub 2019 Feb 5.

Department of Life Sciences, Whitelands College, Roehampton University, London SW15 4JD, United Kingdom.

Worldwide, antibiotic usage exceeds 100,000 tons per year and there is increasing concern over the fate of these substances. Antibiotics are ubiquitous in the environment and significant concentrations have been detected in fresh waters. In this review, we highlight important aspects of antibiotic pollution in fresh waters: that concentrations of antibiotics in the environment are substantial, that micro-organisms are susceptible to this, that bacteria can evolve resistance in the environment, and that antibiotic pollution affects natural food webs while interacting with other stressors; which taken together poses a number of challenges for environmental scientists. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.01.406DOI Listing
February 2019

Climate-growth relationships in a Larix decidua Mill. network in the French Alps.

Sci Total Environ 2019 Feb 5;664:554-566. Epub 2019 Feb 5.

Retired from Aix Marseille Université, CNRS, Ministère de la Culture et de la Communication, CCJ UMR 7299, 13094 Aix en Provence, France.

A better understanding of the respective role of key climatic variables on tree growth is crucial for an accurate assessment of how ongoing global changes may affect both dynamics and distribution of forest tree species in the future. The aim of this study was (i) to explore growth patterns of European larch (Larix decidua Mill.) through a network of tree-ring chronologies developed for the French Alps and (ii) to identify the main climatic drivers explaining radial growth. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.01.404DOI Listing
February 2019

Are there distinct clinical and pathological features distinguishing Idiopathic from Drug-Induced Subacute Cutaneous Lupus Erythematosus? A European retrospective multicenter study.

J Am Acad Dermatol 2019 Feb 11. Epub 2019 Feb 11.

Dermatology - Department Medical Science and Public Health, University of Cagliari, Via Ospedale 54, 09124 Cagliari Italy; European Academy of Dermatology and Venereology (EADV) Task Force of Dermatopathology; SIDEMAST Dermatopathology Study Group of Italian Society of Dermatology.

Background: Clinical and pathological criteria to distinguish drug-induced subacute lupus erythematosus (DI-SCLE) from idiopathic (I-SCLE) are controversial.

Objective: Aim of the survey was a retrospective analysis of a consistent number of iatrogenous and idiopathic SCLE cases, by means of clinical and histopathological investigation.

Methods: Eleven European University Dermatology Units collected all diagnosed cases from January 2000 to December 2016. Read More

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http://dx.doi.org/10.1016/j.jaad.2019.02.009DOI Listing
February 2019

Measles outbreaks in Italy: A paradigm of the re-emergence of vaccine-preventable diseases in developed countries.

Authors:
Alessandro Siani

Prev Med 2019 Feb 11. Epub 2019 Feb 11.

School of Biological Sciences, University of Portsmouth, Portsmouth, UK. Electronic address:

Over the last decade, outbreaks of vaccine-preventable diseases have been reported in developed countries around the world. In particular, measles outbreaks have been ongoing in the European Union since 2017, with the majority of cases concentrated in Romania and Italy. Measles has been identified as a powerful indicator of the status of vaccination programs in a region, as outbreaks have been reported to quickly emerge as a result of underlying problems in the immunisation routine. Read More

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http://dx.doi.org/10.1016/j.ypmed.2019.02.011DOI Listing
February 2019

Scorecard for spina bifida research, prevention, and policy: Score analysis by Human Development Index and WHO region.

Prev Med 2019 Feb 11. Epub 2019 Feb 11.

March of Dimes Inc., USA.

The People and Organizations United for Spina Bifida and Hydrocephalus (PUSH!) Global Alliance created scorecards to rate country-level performance on spina bifida, including folate status among women of reproductive age; birth prevalence and mortality associated with spina bifida; prevention strategies; access to care; and the country's engagement in the UN Convention on the Rights of Persons with Disabilities. A total of 187 countries were examined based on a criteria-based scoring system represented by stars (http://www.pu-sh. Read More

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http://dx.doi.org/10.1016/j.ypmed.2019.02.020DOI Listing
February 2019

[Assessment of the risk of malnutrition in the older age group of the Voronezh Region].

Vopr Pitan 2018 13;87(6):42-47. Epub 2018 Nov 13.

Voronezh State Medical University named after N.N. Burdenko.

Modern scientific data indicate the widespread use in European countries of questioning in assessing the nutritional status of patients. The use of questionnaires in medical practice allows the doctor to reduce the time to collect anamnesis, to place emphasis on building a further algorithm of diagnosis and treatment. The article is devoted to the study of the nutritional status of elderly people in the city of Voronezh and the Region; determining the risk of malnutrition syndrome. Read More

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http://dx.doi.org/10.24411/0042-8833-2018-10065DOI Listing
November 2018

Clinical results of pulsed signal therapy on patellofemoral syndrome with patellar chondropathy.

Bioelectromagnetics 2019 Feb 14. Epub 2019 Feb 14.

Faculdade de Medicina, Hospital das Clinicas HCFMUSP, Universidade de Sao Paulo, Sao Paulo, Brazil.

This study was designed to evaluate the effect of pulsed signal therapy (PST) on patellofemoral pain syndrome associated with patellar chondropathy. A prospective randomized double-blind placebo controlled trial included 25 patients (41 knees) between 20 and 50 years with pain due to isolated patellofemoral syndrome with chondropathy. PST group received nine 60-min daily sessions of PST treatment. Read More

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http://dx.doi.org/10.1002/bem.22172DOI Listing
February 2019

Adherence to guidelines for pharmacological treatment of young adults with myocardial infarction in Poland: Data from Polish Registry of Acute Coronary Syndromes (PL-ACS).

J Clin Pharm Ther 2019 Feb 14. Epub 2019 Feb 14.

Department of Clinical Pharmacy and Pharmaceutical Care, Faculty of Pharmacy with Laboratory Medicine, Medical University of Warsaw, Warsaw, Poland.

What Is Known And Objective: Myocardial infarction (MI) in young adults accounts for up to 10% of all cases. Regarding life expectancy and professional activity, it is extremely important to restore and maintain young patients' full performance. Therefore, secondary prevention is especially vital in this group of patients. Read More

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http://dx.doi.org/10.1111/jcpt.12813DOI Listing
February 2019

A natural history model for planning prostate cancer testing: Calibration and validation using Swedish registry data.

PLoS One 2019 14;14(2):e0211918. Epub 2019 Feb 14.

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

Recent prostate cancer screening trials have given conflicting results and it is unclear how to reduce prostate cancer mortality while minimising overdiagnosis and overtreatment. Prostate cancer testing is a partially observable process, and planning for testing requires either extrapolation from randomised controlled trials or, more flexibly, modelling of the cancer natural history. An existing US prostate cancer natural history model (Gulati et al, Biostatistics 2010;11:707-719) did not model for differences in survival between Gleason 6 and 7 cancers and predicted too few Gleason 7 cancers for contemporary Sweden. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211918PLOS
February 2019

Effects of seniority, gender and geography on the bibliometric output and collaboration networks of European Research Council (ERC) grant recipients.

PLoS One 2019 14;14(2):e0212286. Epub 2019 Feb 14.

Department of Research in Biomedicine and Health, University of Split School of Medicine, Split, Croatia.

Assessing the success and performance of researchers is a difficult task, as their grant output is influenced by a series of factors, including seniority, gender and geographical location of their host institution. In order to assess the effects of these factors, we analysed the publication and citation outputs, using Scopus and Web of Science, and the collaboration networks of European Research Council (ERC) starting (junior) and advanced (senior) grantees. For this study, we used a cohort of 355 grantees from the Life Sciences domain of years 2007-09. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212286PLOS
February 2019

Molecular fungal community and its decomposition activity in sapwood and heartwood of 13 temperate European tree species.

PLoS One 2019 14;14(2):e0212120. Epub 2019 Feb 14.

Technische Universität Dresden, International Institute Zittau, Department of Bio- and Environmental Sciences, Zittau, Germany.

Deadwood is an important structural component in forest ecosystems and plays a significant role in global carbon and nutrient cycling. Relatively little is known about the formation and decomposition of CWD by microbial communities in situ and about the factors controlling the associated processes. In this study, we intensively analyzed the molecular fungal community composition and species richness in relation to extracellular enzyme activity and differences in decomposing sapwood and heartwood of 13 temperate tree species (four coniferous and nine deciduous species, log diameter 30-40 cm and 4 m long) in an artificial experiment involving placing the logs on the forest soil for six years. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212120PLOS
February 2019

A prescription support-tool for chronic management of oral antithrombotic combinations in adults based on a systematic review of international guidelines.

PLoS One 2019 14;14(2):e0211695. Epub 2019 Feb 14.

Sorbonne Université, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique, AP-HP, Hôpital Pitié-Salpêtrière, Département Biostatistique Santé Publique et Information Médicale, Unité de Recherche Clinique PSL-CFX, Centre de Pharmacoépidémiologie (Cephepi), Paris, France.

Background: Oral antithrombotic (AT) drugs, which include antiplatelet and anticoagulant therapies, are widely implicated in serious preventable bleeding events. Avoiding inappropriate oral AT combinations is a major concern. Numerous practical guidelines have been released; a document to enhance prescriptions of oral AT combinations for adults would be of great help. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211695PLOS
February 2019

Genotype and phenotype landscape of MEN2 in 554 medullary thyroid cancer patients: the BrasMEN study.

Endocr Connect 2019 Feb 1. Epub 2019 Feb 1.

A Maia, INTERNAL MEDICINE, UNIVERSIDADE FEDERAL DO RIO GRANDE DO SUL, Porto Alegre, 90035-003, Brazil.

Multiple endocrine neoplasia type 2 (MEN2) is an autosomal dominant genetic disease caused by RET gene germline mutations that is characterized by medullary thyroid carcinoma (MTC) associated with other endocrine tumours. Several reports have demonstrated that the RET mutation profile may vary according to geographical area. In this study we collected clinical and molecular data from 554 patients with surgically confirmed MTC from 176 families with MEN2 in 18 different Brazilian centers to compare the type and prevalence of RET mutations with those from other countries. Read More

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http://dx.doi.org/10.1530/EC-18-0506DOI Listing
February 2019

Reconstruction of defects of the proximal nasal sidewall using the procerus perforator flap.

J Dtsch Dermatol Ges 2019 Feb;17(2):210-213

Department of Dermatology, Venereology and Allergology, Mannheim University Medical Center, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.

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http://dx.doi.org/10.1111/ddg.13752DOI Listing
February 2019

Rekonstruktion eines Defektes am proximalen Nasenabhang mittels Procerus-Insellappenplastik.

J Dtsch Dermatol Ges 2019 Feb;17(2):210-213

Klinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum Mannheim, Medizinische Fakultät Mannheim der Universität Heidelberg, Mannheim, Deutschland.

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http://dx.doi.org/10.1111/ddg.13752_gDOI Listing
February 2019

Lipid Transfer Protein allergy in the United Kingdom; characterisation and comparison with a matched Italian cohort.

Allergy 2019 Feb 14. Epub 2019 Feb 14.

Guy's & St Thomas' NHS Foundation Trust, London, United Kingdom.

Background: Although pollen-related food allergy occurs in all European populations, Lipid Transfer Protein (LTP) allergy is considered to manifests mainly in Mediterranean countries. We aimed to characterise adults presenting with LTP allergy in a Northern European country.

Method: The clinical history and sensitisation patterns of subjects born and residing in the United Kingdom (UK), with a prior diagnosis of LTP allergy and sensitisation to the peach LTP allergen Pru p 3, were compared to UK subjects with pollen food syndrome (PFS). Read More

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http://dx.doi.org/10.1111/all.13747DOI Listing
February 2019

What Is the Possible Impact of High Variability of Distal Femoral Geometry on TKA? A CT Data Analysis of 24,042 Knees.

Clin Orthop Relat Res 2019 Mar;477(3):561-570

M. Meier, J. Beckmann, Sportklinik Stuttgart, Stuttgart, Germany S. Zingde, Conformis Inc, Billerica, MA, USA A. Steinert, Krankenhaus Agatharied, Hausham, Germany W. Kurtz, Tennessee Orthopaedic Alliance, Nashville, TN, USA F. Koeck, MedArtes, Neutraubling, Germany.

Background: Previous studies analyzing femoral components of TKAs have demonstrated the limited ability of these components to accommodate size variations seen in the patient population, particularly width and femoral offset.

Questions/purposes: The purpose of this study was to use a large data set of knee CT scans (1) to determine the variations in the distal and posterior femoral geometries and to determine whether there is a correlation between distal condylar offset and posterior femoral offset as a potential parameter for symmetry/asymmetry; and (2) to evaluate what proportion of knees would have a substantial mismatch between the implant's size or shape and the patient's anatomy if a femoral component of a modern standard TKA of symmetric (sTKA) or asymmetric (asTKA) designs were to be used.

Methods: A retrospective study was performed on 24,042 data sets that were generated during the design phase for a customized TKA implant. Read More

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http://dx.doi.org/10.1097/CORR.0000000000000611DOI Listing

Validation of noninvasive oscillometric blood pressure 2020 up pressure upper arm blood pressure monitoring technology according to the European Society of Hypertension International Protocol revision 2010.

Blood Press Monit 2019 Feb 11. Epub 2019 Feb 11.

Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Campus Benjamin Franklin, Department of Nephrology.

To validate noninvasive oscillometric blood pressure (NIBP) 2020 up pressure (UP) upper arm blood pressure (BP) monitoring technology according to the European Society of Hypertension International Protocol revision 2010 (ESH-IP revision 2010). According to the protocol, 33 participants were included. NIBP2020 UP technology was integrated into the BP+ host device, and common upper arm cuffs were used. Read More

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http://dx.doi.org/10.1097/MBP.0000000000000370DOI Listing
February 2019

Cost-effectiveness, cost-utility and the budget impact of antidepressants versus preventive cognitive therapy with or without tapering of antidepressants.

BJPsych Open 2019 Jan;5(1):e12

Professor of Clinical Psychology in Psychiatry,Amsterdam UMC, location AMC,Department of Psychiatry,University of Amsterdam,the Netherlands.

Background: As depression has a recurrent course, relapse and recurrence prevention is essential.AimsIn our randomised controlled trial (registered with the Nederlands trial register, identifier: NTR1907), we found that adding preventive cognitive therapy (PCT) to maintenance antidepressants (PCT+AD) yielded substantial protective effects versus antidepressants only in individuals with recurrent depression. Antidepressants were not superior to PCT while tapering antidepressants (PCT/-AD). Read More

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http://dx.doi.org/10.1192/bjo.2018.81DOI Listing
January 2019

Biological Contamination Prevention for Outer Solar System Moons of Astrobiological Interest: What Do We Need to Know?

Astrobiology 2019 Feb 14. Epub 2019 Feb 14.

15 Eurospace, Paris, France.

To ensure that scientific investments in space exploration are not compromised by terrestrial contamination of celestial bodies, special care needs to be taken to preserve planetary conditions for future astrobiological exploration. Significant effort has been made and is being taken to address planetary protection in the context of inner Solar System exploration. In particular for missions to Mars, detailed internationally accepted guidelines have been established. Read More

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http://dx.doi.org/10.1089/ast.2018.1996DOI Listing
February 2019

No flexibility in letter position coding in Korean.

J Exp Psychol Hum Percept Perform 2019 Feb 14. Epub 2019 Feb 14.

Department of Psychology, Sogang University.

Substantial research across Indo-European languages suggests that readers display a degree of uncertainty in letter position coding. For example, readers perceive transposed-letter stimuli, such as jugde, as similar to their base words (e.g. Read More

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http://dx.doi.org/10.1037/xhp0000617DOI Listing
February 2019

Fasting guidelines concerning intake of solids of the American Society of Anesthesiologists are not in concert with those of the European Society of Anaesthesiologists.

Authors:
Alexander Avidan

Minerva Anestesiol 2019 Feb 13. Epub 2019 Feb 13.

Department of Anesthesiology, Critical Care and Pain Medicine, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel -

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http://dx.doi.org/10.23736/S0375-9393.19.13553-5DOI Listing
February 2019

Death domain of p75 neurotrophin receptor: a structural perspective on an intracellular signalling hub.

Biol Rev Camb Philos Soc 2019 Feb 14. Epub 2019 Feb 14.

School of Life Sciences, Tianjin University, Tianjin, 300072, People's Republic of China.

The death domain (DD) is a globular protein motif with a signature feature of an all-helical Greek-key motif. It is a primary mediator of a variety of biological activities, including apoptosis, cell survival and cytoskeletal changes, which are related to many neurodegenerative diseases, neurotrauma, and cancers. DDs exist in a wide range of signalling proteins including p75 neurotrophin receptor (p75 ), a member of the tumour necrosis factor receptor superfamily. Read More

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http://dx.doi.org/10.1111/brv.12502DOI Listing
February 2019

Prognostic impact of left ventricular ejection fraction in patients with electrical storm.

J Interv Card Electrophysiol 2019 Feb 14. Epub 2019 Feb 14.

First Department of Medicine, University Medical Centre Mannheim (UMM), Faculty of Medicine Mannheim, University of Heidelberg, European Center for AngioScience (ECAS), and DZHK (German Center for Cardiovascular Research) partner site Heidelberg/Mannheim, Mannheim, Germany.

Objectives: The study sought to assess retrospectively the prognostic impact of left ventricular ejection fraction (LVEF) in patients with electrical storm (ES).

Background: Data regarding the prognostic impact of impaired LVEF in ES patients is rare.

Methods: Consecutive patients presenting with ES from 2002 to 2016 were included retrospectively. Read More

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http://dx.doi.org/10.1007/s10840-019-00525-yDOI Listing
February 2019

Long-term responses of Scots pine (Pinus sylvestris L.) and European beech (Fagus sylvatica L.) to the contamination of light soils with diesel oil.

Environ Sci Pollut Res Int 2019 Feb 14. Epub 2019 Feb 14.

Department of Chemistry, Research Group of Environmental Toxicology, Faculty of Environmental Management and Agriculture, University of Warmia and Mazury in Olsztyn, ul. Prawocheńskiego 17, 10-720, Olsztyn, Poland.

Research into trees plays a very important role in evaluations of soil contamination with diesel oil. Trees are ideal for reclaiming contaminated soils because their large biomass renders them more resistant to higher concentrations of pollutants. In the literature, there is a general scarcity of long-term studies performed on trees, in particular European beeches. Read More

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http://dx.doi.org/10.1007/s11356-019-04328-6DOI Listing
February 2019

Parkinson's disease among migrants in Europe: estimating the magnitude of an emerging phenomenon.

J Neurol 2019 Feb 14. Epub 2019 Feb 14.

Department of Human Neuroscience, Sapienza University, Viale dell'Università 30, 00185, Rome, Italy.

Introduction: The occurrence of age-related pathological conditions among subjects with a migration background and composing ethnic minorities is an emerging challenge for Western countries. Specifically, the onset of neurodegenerative diseases in these populations of individuals might assume special relevance and generate additional complexities for our healthcare systems. The aim of the present study was to estimate the number of Parkinson's disease (PD) cases in migrant subjects living in Europe. Read More

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http://dx.doi.org/10.1007/s00415-019-09241-zDOI Listing
February 2019

Effects of three husbandry systems on health, welfare and productivity of organic pigs.

Animal 2019 Feb 14:1-9. Epub 2019 Feb 14.

10Institute of Animal Welfare and Animal Husbandry,Friedrich-Loeffler-Institute,Dörnbergstraße 25/27,29223 Celle,Germany.

Organic pig husbandry systems in Europe are diverse - ranging from indoor systems with concrete outside run (IN) to outdoor systems all year round (OUT) and combinations of both on one farm (POUT). As this diversity has rarely been taken into account in research projects on organic pig production, the aim of this study was to assess and compare pig health, welfare and productivity in these three systems. Animal health and welfare were assessed using direct observation and records of 22 animal-based measures, comprising 17 health-, 3 productivity- and 2 behavioural measures. Read More

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http://dx.doi.org/10.1017/S1751731119000041DOI Listing
February 2019

Contemporary practice of CRT implantation in Scandinavia compared to Europe.

Scand Cardiovasc J 2019 Feb 14:1-15. Epub 2019 Feb 14.

f Department of Cardiology , The Heart Centre , Rigshospitalet , University of Copenhagen , Copenhagen , Denmark.

Objectives: To compare the contemporary practice of CRT implantation in Scandinavia and Europe.

Design: We used data from The European CRT Survey II to highlight similarities and differences in the practice of CRT implantation between Europe (EUR) and Scandinavia (SCAND) and between the Scandinavian countries Denmark, Norway and Sweden. Implant data from the national pacemaker registries were used to calculate coverage. Read More

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http://dx.doi.org/10.1080/14017431.2019.1583364DOI Listing
February 2019

Prevalence of multiple sclerosis in an urban population of Sivas province in Turkey

Turk J Med Sci 2019 Feb 11;49(1):288-294. Epub 2019 Feb 11.

Background/aim: Multiple sclerosis (MS) is a common neurological disorder that can be a leading cause of nontraumatic disability in several countries. Recent reports have indicated a moderate to high risk of MS in European countries. In this study, we examined the prevalence of MS in a well-defined urban population of provincial center in Sivas Province in Turkey. Read More

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http://dx.doi.org/10.3906/sag-1808-112DOI Listing
February 2019

Personalization of therapies in rare diseases: a translational approach for the treatment of cystic fibrosis.

Minerva Pediatr 2019 Feb 13. Epub 2019 Feb 13.

European Institute for Research in Cystic Fibrosis, San Raffaele Scientific Institute, Milan, Italy -

High variability in the response rates to treatments can make the interpretation of data from clinical trials very difficult, particularly in rare genetic diseases in which the enrolment of thousands of patients is problematic. Personalized medicine largely depends on the establishment of appropriate early detectors of drug efficacy that may guide the administration (or discontinuation) of specific treatments. Such biomarkers should be capable of predicting the therapeutic response of individual patients and of monitoring early benefits of candidate drugs before late clinical benefits become evident. Read More

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http://dx.doi.org/10.23736/S0026-4946.19.05511-7DOI Listing
February 2019

Inhaled medications in cystic fibrosis beyond antibiotics.

Minerva Pediatr 2019 Feb 13. Epub 2019 Feb 13.

Department of Translational Medical Sciences, University Federico II, Naples, Italy -

Structural lung disease begins very early in children with Cystic Fibrosis, often in the first three months of life. Inhaled medications represent an attractive therapeutic approach in Cystic Fibrosis that are routinely used as early intervention strategies. Two aerosolized solutions, hypertonic saline and dornase alfa, have significant potential benefits by improving mucociliary clearance, with minimal associated side-effects. Read More

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http://dx.doi.org/10.23736/S0026-4946.19.05509-9DOI Listing
February 2019

Mutation-specific therapies and drug repositioning in cystic fibrosis.

Minerva Pediatr 2019 Feb 13. Epub 2019 Feb 13.

European Institute for Research in Cystic Fibrosis, San Raffaele Scientific Institute, Milan, Italy -

Cystic Fibrosis (CF) is an inherited, prematurely lethal rare disease affecting more than 85,000 people worldwide. CF is caused by more than 2000 loss-of-function mutations in the gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR). This review summarizes recent advances in the etiological therapies of CF that aim at repairing the functional defect of CFTR by means of CFTR modulators. Read More

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http://dx.doi.org/10.23736/S0026-4946.19.05506-3DOI Listing
February 2019

[Use of multiparametric magnetic resonance imaging in t-staging of prostate cancer: a multicenter study].

Urologiia 2018 Oct(4):106-112

European Medical Center, Moscow, Russia.

Aim: The study aimed to analyze the diagnostic performance of preoperative multiparametric magnetic resonance imaging (mp-MRI) in the staging of prostate cancer (PCa) versus postoperative histological examination and determine the most sensitive pulse sequence from the mp-MRI protocol in estimating the local extent of PCa.

Materials And Methods: The study comprised 112 men aged 52 to 84 years with a morphologically verified diagnosis of prostate cancer. All patients underwent pelvic mp-MRI before radical prostatectomy (RPE) no earlier than six weeks after the prostate biopsy. Read More

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October 2018

Real-world effectiveness and safety of rituximab in the treatment of rheumatoid arthritis: A single-center experience in Taiwan.

Int J Rheum Dis 2019 Feb 13. Epub 2019 Feb 13.

Division of Allergy, Immunology and Rheumatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.

Aim: To assess the real-world effectiveness and safety of rituximab (RTX) at 24 months in patients with established rheumatoid arthritis (RA) and to identify predictors of low disease activity/remission and a good European League Against Rheumatism (EULAR) response.

Methods: Seventy RTX-treated RA patients were enrolled. Predictors for low disease activity/remission and a good EULAR response at 24 months were identified by multivariate analyses. Read More

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http://dx.doi.org/10.1111/1756-185X.13511DOI Listing
February 2019

Characteristics of CF-related Diabetes: Data from Two Different Sources the ECFS Patient Registry and the DPV Registry.

Pediatr Diabetes 2019 Feb 13. Epub 2019 Feb 13.

Institute of Epidemiology and Medical Biometry, Central Institute for Biomedical Technology, University of Ulm, 89081 Ulm, Germany.

Background: Standardized patient registries provide a unique basis to get insight into cystic fibrosis-related diabetes (CFRD), the most common comorbidity in cystic fibrosis.

Methods: 3,853 CFRD patients from the European CF Society Patient Registry (ECFSPR) and 752 from the German/Austrian diabetes prospective follow-up (DPV) were studied. To adjust for age and sex, multivariable regression was used (SAS 9. Read More

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http://dx.doi.org/10.1111/pedi.12831DOI Listing
February 2019

Estimating effects of arable land-use intensity on farmland birds using joint species modeling.

Ecol Appl 2019 Feb 14:e01875. Epub 2019 Feb 14.

Biodiversity unit, Department of Biology and Centre for Environmental and Climate Research, Lund University, Sölvegatan 37, SE, 223 62, Lund, Sweden.

Declines in European farmland birds over past decades have been attributed to the combined effects of agricultural intensification and abandonment. Consequently, aspirations to stop declines should focus attention to reversing these changes through voluntary or policy driven interventions. The design of such interventions should ideally be informed by scientific knowledge of which aspects of the transformation of agricultural landscapes have contributed to the farmland bird declines. Read More

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http://dx.doi.org/10.1002/eap.1875DOI Listing
February 2019

Emotional functioning to screen for psychological distress in breast and colorectal cancer patients prior to adjuvant treatment initiation.

Eur J Cancer Care (Engl) 2019 Feb 13:e13005. Epub 2019 Feb 13.

Department of Medical Oncology. Hospital, Universitario Central de Asturias, Oviedo, Spain.

Introduction: The objective was to analyze the usefulness of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC-QLQ-C30) EF subscale to detect emotional problems in patients with breast (BC) and colorectal cancer (CRC).

Methods: A prospective, observational, cross-sectional study was conducted. Participants completed the Brief Symptom Inventory (BSI) and EORTC-QLQ-C30. Read More

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http://dx.doi.org/10.1111/ecc.13005DOI Listing
February 2019

Serum neurofilaments increase at PML onset in natalizumab-treated MS patients.

Ann Neurol 2019 Feb 13. Epub 2019 Feb 13.

Department of Neurology, San Raffaele Hospital, Milan, Italy.

This study analyzed serum neurofilament light chains (NfL) in 2 European cohorts of 312 MS patients to investigate whether NfL are biomarkers of PML during natalizumab treatment. The cohort comprised 25 PML, 136 natalizumab-treated, and 151 untreated MS patients. Patients subsequently developing PML had similar NfL to other natalizumab-treated MS patients. Read More

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http://dx.doi.org/10.1002/ana.25437DOI Listing
February 2019

Persistence and Diffusion of C-Positive CC130 MRSA Isolates in Dairy Farms in Meurthe-et-Moselle County (France).

Front Microbiol 2019 30;10:47. Epub 2019 Jan 30.

Pathogénie des Infections à Staphylocoque, Centre International de Recherche en Infectiologie, Lyon, France.

Methicillin resistance in (MRSA) is classically conferred by the acquisition of the A gene encoding an additional penicillin binding protein with low affinity for beta-lactams. A A variant, named C, was described in 2011. MRSA isolates harboring C of both animal and human origin have since been collected in different European countries. Read More

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http://dx.doi.org/10.3389/fmicb.2019.00047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363682PMC
January 2019

From Pig Breeding Environment to Subsequently Produced Pork: Comparative Analysis of Antibiotic Resistance Genes and Bacterial Community Composition.

Front Microbiol 2019 29;10:43. Epub 2019 Jan 29.

Institute for Advanced Study, Shenzhen University, Shenzhen, China.

It is well verified that pig farms are an important reservoir and supplier of antibiotic resistance genes (ARGs). However, little is known about the transmission of ARGs between the breeding environment and subsequently produced pork. This study was conducted to investigate if ARGs and associated host bacteria spread from the breeding environment onto the meat through the food production chain. Read More

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http://dx.doi.org/10.3389/fmicb.2019.00043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361818PMC
January 2019

A Perception on Genome-Wide Genetic Analysis of Metabolic Traits in Arab Populations.

Front Endocrinol (Lausanne) 2019 28;10. Epub 2019 Jan 28.

Genetics and Bioinformatics Unit, Dasman Diabetes Institute, Kuwait City, Kuwait.

Despite dedicated nation-wide efforts to raise awareness against the harmful effects of fast-food consumption and sedentary lifestyle, the Arab population continues to struggle with an increased risk for metabolic disorders. Unlike the European population, the Arab population lacks well-established genetic risk determinants for metabolic disorders, and the transferability of established risk loci to this population has not been satisfactorily demonstrated. The most recent findings have identified over 240 genetic risk loci (with ~400 independent association signals) for type 2 diabetes, but thus far only 25 risk loci (, ALX4, , COL8A1, γ, and ) have been replicated in Arab populations. Read More

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http://dx.doi.org/10.3389/fendo.2019.00008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362414PMC
January 2019

On the Use of Nudges to Affect Spillovers in Environmental Behaviors.

Front Psychol 2019 29;10:61. Epub 2019 Jan 29.

Department of Management, Economics and Industrial Engineering, Politecnico di Milano, Milan, Italy.

Environmental self-identity is considered a promising lever to generate positive spillovers across pro-environmental behaviors: existing evidence shows that it is positively correlated with pro-environmental choices and that it can be easily manipulated, by reminding individuals of their past pro-environmental actions. However, it remains unclear whether it can be successfully used for environmental policy making. In two online, incentive-compatible experiments, we manipulate participants' environmental self-identity and test whether this leads to increased donations to an environmental charity. Read More

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http://dx.doi.org/10.3389/fpsyg.2019.00061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362870PMC
January 2019

A Comprehensive Analysis of Population Differences in Variant Distribution in Parkinson's Disease.

Front Aging Neurosci 2019 30;11:13. Epub 2019 Jan 30.

Department of Neurology, Xiangya Hospital, Central South University, Changsha, China.

variants have been demonstrated to have distinct distributions in different populations. However, researchers have thus far chosen to focus on relatively few variants, such as R1628P, G2019S, and G2385R. We therefore investigated the relationship between common variants and PD risk in various populations. Read More

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http://dx.doi.org/10.3389/fnagi.2019.00013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363667PMC
January 2019

Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond.

Nat Rev Drug Discov 2019 Feb 13. Epub 2019 Feb 13.

DKTK Brain Cancer Metabolism Group, German Cancer Research Center (DKFZ), INF 280, Heidelberg, Germany.

L-Tryptophan (Trp) metabolism through the kynurenine pathway (KP) is involved in the regulation of immunity, neuronal function and intestinal homeostasis. Imbalances in Trp metabolism in disorders ranging from cancer to neurodegenerative disease have stimulated interest in therapeutically targeting the KP, particularly the main rate-limiting enzymes indoleamine-2,3-dioxygenase 1 (IDO1), IDO2 and tryptophan-2,3-dioxygenase (TDO) as well as kynurenine monooxygenase (KMO). However, although small-molecule IDO1 inhibitors showed promise in early-stage cancer immunotherapy clinical trials, a phase III trial was negative. Read More

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http://dx.doi.org/10.1038/s41573-019-0016-5DOI Listing
February 2019

Candidate gene analyses for acute pain and morphine analgesia after pediatric day surgery: African American versus European Caucasian ancestry and dose prediction limits.

Pharmacogenomics J 2019 Feb 14. Epub 2019 Feb 14.

Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Acute pain and opioid analgesia demonstrate inter-individual variability and polygenic influence. In 241 children of African American and 277 of European Caucasian ancestry, we sought to replicate select candidate gene associations with morphine dose and postoperative pain and then to estimate dose prediction limits. Twenty-seven single-nucleotide polymorphisms (SNPs) from nine genes (ABCB1, ARRB2, COMT, DRD2, KCNJ6, MC1R, OPRD1, OPRM1, and UGT2B7) met selection criteria and were analyzed along with TAOK3. Read More

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http://dx.doi.org/10.1038/s41397-019-0074-4DOI Listing
February 2019

Immunofluorescence Tomography: High-resolution 3-D reconstruction by serial-sectioning of methacrylate embedded tissues and alignment of 2-D immunofluorescence images.

Sci Rep 2019 Feb 13;9(1):1992. Epub 2019 Feb 13.

European Cancer Stem Cell Research Institute, Cardiff University, Maindy Rd, Cardiff, Wales, United Kingdom.

Immunofluorescence tomography is a high-resolution 3-D reconstruction method based on methacrylate embedding and serial-sectioning, where 2-D images of immuno-stained serial-sections are computationally aligned into image stacks, and the 3-D volume rendered. Butyl-Methyl Methacrylate (BMMA) plastic was adopted as it preserves excellent tissue morphology and can be de-plasticized easily using an organic solvent, which enables immuno-staining of serial-sections without antibody penetration issues over millimeters of 3-D reconstructed tissue (Z-depth). High axial Z-resolution over a large volume was achieved by cutting serial-sections at 2 µm thickness. Read More

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http://dx.doi.org/10.1038/s41598-018-38232-9DOI Listing
February 2019

Polygenic risk for neuropsychiatric disease and vulnerability to abnormal deep grey matter development.

Sci Rep 2019 Feb 13;9(1):1976. Epub 2019 Feb 13.

Centre for the Developing Brain, School of Biomedical Engineering & Imaging Sciences, King's College London, London, SE1 7EH, United Kingdom.

Neuropsychiatric disease has polygenic determinants but is often precipitated by environmental pressures, including adverse perinatal events. However, the way in which genetic vulnerability and early-life adversity interact remains obscure. We hypothesised that the extreme environmental stress of prematurity would promote neuroanatomic abnormality in individuals genetically vulnerable to psychiatric disorders. Read More

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http://www.nature.com/articles/s41598-019-38957-1
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http://dx.doi.org/10.1038/s41598-019-38957-1DOI Listing
February 2019
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In-Depth Characterization of Monocyte-Derived Macrophages using a Mass Cytometry-Based Phagocytosis Assay.

Sci Rep 2019 Feb 13;9(1):1925. Epub 2019 Feb 13.

Institute of Molecular Life Sciences, University of Zürich, Winterthurerstrasse 190, 8057, Zürich, Switzerland.

Phagocytosis is a process in which target cells or particles are engulfed and taken up by other cells, typically professional phagocytes; this process is crucial in many physiological processes and disease states. The detection of targets for phagocytosis is directed by a complex repertoire of cell surface receptors. Pattern recognition receptors directly detect targets for binding and uptake, while opsonic and complement receptors detect objects coated by soluble factors. Read More

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http://dx.doi.org/10.1038/s41598-018-38127-9DOI Listing
February 2019