302,204 results match your criteria European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences[Journal]


An updated European Organisation for Research and Treatment of Cancer (EORTC) protocol for pathological evaluation of sentinel lymph nodes for melanoma.

Eur J Cancer 2019 Apr 17;114:1-7. Epub 2019 Apr 17.

Department of Surgical Oncology, Netherlands Cancer Institute Antoni van Leeuwenhoek, Amsterdam, the Netherlands.

The sentinel lymph node (SLN) biopsy is a highly accurate staging procedure and the most important prognostic factor in melanoma patients. The European Organisation for Research and Treatment of Cancer (EORTC) Melanoma Group aimed to design an updated evolved SLN protocol for the histopathological workup and reporting. We herein recommend extending the distance between steps according to the short axis dimension of the lymph node and optimise both conventional sectioning and staining procedures including immunohistochemistry. Read More

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http://dx.doi.org/10.1016/j.ejca.2019.03.010DOI Listing

High-resolution large-area imaging of nanoscale structure and mineralization of a sclerosing osteosarcoma in human bone.

J Struct Biol 2019 Apr 17. Epub 2019 Apr 17.

Department of Material Sciences and Process Engineering, University of Natural Resources and Life Sciences, Vienna, Austria.

Osteosarcoma is the most common primary bone cancer type in humans. It is predominantly found in young individuals, with a second peak later in life. The tumour is formed by malignant osteoblasts and consists of collagenous, sometimes also mineralized, bone matrix. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10478477193007
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http://dx.doi.org/10.1016/j.jsb.2019.04.012DOI Listing
April 2019
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Impact of the replacement of dietary fish oil by animal fats and environmental salinity on the metabolic response of European Seabass (Dicentrarchus labrax).

Comp Biochem Physiol B Biochem Mol Biol 2019 Apr 17. Epub 2019 Apr 17.

CIIMAR-Interdisciplinary Centre of Marine and Environmental Research, University of Porto, Portugal. Electronic address:

The replacement of fish oil (FO) with other lipid sources (e.g. animal fats, AF) in aquafeeds improves the sustainability of aquaculture, even though alternatives have different fatty acid (FA) profiles. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10964959183032
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http://dx.doi.org/10.1016/j.cbpb.2019.04.004DOI Listing
April 2019
1 Read

30 Years (and More) of Hair Research Societies.

J Am Acad Dermatol 2019 Apr 17. Epub 2019 Apr 17.

The Society for Hair Science Research (Japan), Okubo 2-4-12, Shinjuku-ku, Shunkosha, Co. 169-0072 Tokyo, Japan.

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http://dx.doi.org/10.1016/j.jaad.2019.04.028DOI Listing

Correlations between Computational Fluid Dynamics and clinical evaluation of nasal airway obstruction due to septal deviation: an observational study.

Clin Otolaryngol 2019 Apr 20. Epub 2019 Apr 20.

APHM, Department of Oto-Rhino-Laryngology and Head and Neck Surgery, La Conception University Hospital, 13385, Marseille Cedex, France.

Objectives: The primary objective of this study was to determine how Computational Fluid Dynamics (CFD) could be correlated to clinical evaluation of Nasal Airway Obstruction (NAO) in a population of patients with symptomatic septal deviation (SD). The secondary objective was to determine whether CFD could define which side was the more obstructed.

Design: This was an observational study. Read More

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http://dx.doi.org/10.1111/coa.13344DOI Listing

Photosafety of the Antidiabetic Drug Sitagliptin.

Photodermatol Photoimmunol Photomed 2019 Apr 20. Epub 2019 Apr 20.

Instituto de Investigación Sanitaria (IIS) La Fe, Hospital Universitari i Politècnic La Fe, Avenida de Fernando Abril Martorell 106, 46026, Valencia, Spain.

Sitagliptin (SIT) is a dipeptidyl-peptidase inhibitor, used as an oral hypoglycaemic drug. It is often combined with metformin (MET), for the treatment of type 2 diabetes mellitus (T2DM), which is a chronic disease of high prevalence. The European Medicines Agency (EMA) reported, in 2007, several side effects related to SIT (Januvia ); however photosensitivity was not included as part of its adverse reactions. Read More

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http://dx.doi.org/10.1111/phpp.12475DOI Listing

Perception of Western governments' hostility to Islam among European Muslims before and after ISIS: the important roles of residential segregation and education.

Br J Sociol 2019 Apr 19. Epub 2019 Apr 19.

University of Oklahoma.

Perception of Western governments' hostility to Islam is one of the indicating features of Islamic fundamentalism and, in some cases, is serving as a pull to join extremist groups. In this paper, using data from two waves of a cross-national survey, we investigate what affects European Muslims' opinions about Western governments. We find that residential segregation is associated with perceived hostility of Western governments to Islam. Read More

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http://dx.doi.org/10.1111/1468-4446.12673DOI Listing

Missing the Match Might Not Cost You the Game: Primer-Template Mismatches Studied in Different Hepatitis A Virus Variants.

Food Environ Virol 2019 Apr 19. Epub 2019 Apr 19.

European Union Reference Laboratory (EURL) for Foodborne Viruses, National Food Agency, Hamnesplanaden 5, 453 23, Uppsala, Sweden.

Mismatches between template sequences and reverse transcription (RT) or polymerase chain reaction (PCR) primers can lead to underestimation or false negative results during detection and quantification of sequence-diverse viruses. We performed an in silico inclusivity analysis of a widely used RT-PCR assay for detection of hepatitis A virus (HAV) in food, described in ISO 15216-1. One of the most common mismatches found was a single G (primer) to U (template) mismatch located at the terminal 3'-end of the reverse primer region. Read More

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http://dx.doi.org/10.1007/s12560-019-09387-zDOI Listing

Overweight in family members of probands with ADHD.

Eur Child Adolesc Psychiatry 2019 Apr 19. Epub 2019 Apr 19.

Karakter Child and Adolescent Psychiatry University Center, Reinier Postlaan 12, 6525 GC, Nijmegen, The Netherlands.

The widely reported association between ADHD and overweight may be attributable to genetic and environmental factors also present in unaffected family members. Therefore, the purpose of this study was to examine the association between ADHD and overweight within families. A cohort was used of families with at least one member with ADHD, recruited as part of the Dutch node of the International Multicenter ADHD Genetics (IMAGE) study, with assessments taking place between 2003 and 2006, 2009 and 2012, and 2013 and 2015. Read More

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http://link.springer.com/10.1007/s00787-019-01331-7
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http://dx.doi.org/10.1007/s00787-019-01331-7DOI Listing
April 2019
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Cardiovascular Risk in Type 1 Diabetes Mellitus.

Diabetes Ther 2019 Apr 19. Epub 2019 Apr 19.

Cardiovascular Research Group, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, M13 9WU, UK.

Type 1 diabetes mellitus (T1DM) is associated with premature cardiovascular disease (CVD), but the underlying mechanisms remain poorly understood. The American Diabetes Association and the European Association for the Study of Diabetes recently updated their position statement on the management of type 2 diabetes mellitus (T2DM) to include additional focus on cardiovascular risk; improved management of risk factors in T1DM is also needed. There are important differences in the pathophysiology of CVD in T1DM and T2DM. Read More

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http://dx.doi.org/10.1007/s13300-019-0612-8DOI Listing

Evaluation of the draft guidelines proposed by EMA and FDA for the clinical diagnosis of acute uncomplicated cystitis in women.

World J Urol 2019 Apr 19. Epub 2019 Apr 19.

Department of Urology, Pediatric Urology and Andrology, Justus-Liebig-University, Rudolph-Buchheim Str.7, 35392, Giessen, Germany.

Purpose: To reassess the diagnostic values of the "draft" guidelines for the clinical diagnosis of acute uncomplicated cystitis (AC), recently proposed by US Food and Drug Administration (FDA) and European Medicines Agency (EMA).

Methods: The data of 517 female respondents (patients with acute cystitis and controls) derived from the e-USQOLAT database were analyzed and used for the validation of proposed "draft" guidelines of FDA and EMA, compared to the Acute Cystitis Symptom Score (ACSS) questionnaire. The diagnostic values of the proposals concerning signs, symptoms and their severity were assessed and compared. Read More

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http://dx.doi.org/10.1007/s00345-019-02761-3DOI Listing

The dynamics of self-control: within-participant modeling of binary food choices and underlying decision processes as a function of restrained eating.

Psychol Res 2019 Apr 19. Epub 2019 Apr 19.

Department of Psychology, Centre for Cognitive Neuroscience, Paris-Lodron-University of Salzburg, Hellbrunner Straße 34, 5020, Salzburg, Austria.

Successful self-control during food choice might require inhibition of impulses to avoid indulging in tempting but calorie-dense foods, and this might particularly apply to individuals restraining their food intake. Adopting a novel within-participant modeling approach, we tested 62 females during a mouse-tracking based binary food choice task. Subsequent ratings of foods on palatability, healthiness, and calorie density were modeled as predictors for both decision outcome (choice) and decision process (measures of self-control conflict) while considering the moderating role of restrained eating. Read More

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http://dx.doi.org/10.1007/s00426-019-01185-3DOI Listing

Cross-sectional association between blood pressure status and atrial fibrillation in an elderly Chinese population.

Am J Hypertens 2019 Apr 20. Epub 2019 Apr 20.

Center for Epidemiological Studies and Clinical Trials, Shanghai Key Laboratory of Hypertension, The Shanghai Institute of Hypertension, Department of Hypertension, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Objective: Atrial fibrillation(AF) and hypertension are prevalent chronic disease conditions in the elderly. In the present cross-sectional study, we investigated the association between blood pressure (BP) and AF in an elderly Chinese population.

Method: Our elderly (≥65 years) subjects were residents recruited from 6 communities in Shanghai from 2006 to 2017. Read More

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http://dx.doi.org/10.1093/ajh/hpz060DOI Listing

Applicability of the mutation-selection balance model to population genetics of heterozygous protein-truncating variants in humans.

Mol Biol Evol 2019 Apr 19. Epub 2019 Apr 19.

Brigham and Women's Hospital, Division of Genetics, Harvard Medical School, Boston, MA, USA.

The fate of alleles in the human population is believed to be highly affected by the stochastic force of genetic drift. Estimation of the strength of natural selection in humans generally necessitates a careful modeling of drift including complex effects of the population history and structure. Protein-truncating variants (PTVs) are expected to evolve under strong purifying selection and to have a relatively high per-gene mutation rate. Read More

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http://dx.doi.org/10.1093/molbev/msz092DOI Listing

5-HTT independent effects of fluoxetine on neuroplasticity.

Sci Rep 2019 Apr 19;9(1):6311. Epub 2019 Apr 19.

Institut de Psychiatrie et Neurosciences de Paris, Inserm, U 1266, Paris, France.

Selective serotonin reuptake inhibitors are among the most prescribed antidepressants. Fluoxetine is the lead molecule which exerts its therapeutic effects, at least in part, by promoting neuroplasticity through increased brain-derived neurotrophic factor (BDNF)/tropomyosin-related receptor kinase B (TrkB) signalling. It is unclear however, to which extent the neuroplastic effects of fluoxetine are solely mediated by the inhibition of the serotonin transporter (5-HTT). Read More

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http://www.nature.com/articles/s41598-019-42775-w
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http://dx.doi.org/10.1038/s41598-019-42775-wDOI Listing
April 2019
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Interaction of RNA viruses of the natural virome with the African malaria vector, Anopheles coluzzii.

Sci Rep 2019 Apr 19;9(1):6319. Epub 2019 Apr 19.

Department of Parasites and Insect Vectors, Unit of Genetics and Genomics of Insect Vectors, Institut Pasteur, Paris, 75724 CEDEX 15, France.

Mosquitoes are colonized by a little-studied natural virome. Like the bacterial microbiome, the virome also probably influences the biology and immunity of mosquito vector populations, but tractable experimental models are lacking. We recently discovered two novel viruses in the virome of wild Anopheles and in colonies of the malaria vector Anopheles coluzzii: Anopheles C virus and Anopheles cypovirus. Read More

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http://dx.doi.org/10.1038/s41598-019-42825-3DOI Listing

Fingerprinting of Proteins that Mediate Quagga Mussel Adhesion using a De Novo Assembled Foot Transcriptome.

Sci Rep 2019 Apr 19;9(1):6305. Epub 2019 Apr 19.

Institute of Biomaterials & Biomedical Engineering, University of Toronto, Toronto, ON, Canada.

The European freshwater mollusk Dreissena bugensis (quagga mussel), an invasive species to North America, adheres to surfaces underwater via the byssus: a non-living protein 'anchor'. In spite of its importance as a biofouling species, the sequence of the majority of byssal proteins responsible for adhesion are not known, and little genomic data is available. To determine protein sequence information, we utilized next-generation RNA sequencing and de novo assembly to construct a cDNA library of the quagga mussel foot transcriptome, which contains over 200,000 transcripts. Read More

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http://www.nature.com/articles/s41598-019-41976-7
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http://dx.doi.org/10.1038/s41598-019-41976-7DOI Listing
April 2019
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Component of splicing factor SF3b plays a key role in translational control of polyribosomes on the endoplasmic reticulum.

Proc Natl Acad Sci U S A 2019 Apr 19. Epub 2019 Apr 19.

Nippi Research Institute of Biomatrix, Toride, 302-0017 Ibaraki, Japan;

One of the morphological hallmarks of terminally differentiated secretory cells is highly proliferated membrane of the rough endoplasmic reticulum (ER), but the molecular basis for the high rate of protein biosynthesis in these cells remains poorly documented. An important aspect of ER translational control is the molecular mechanism that supports efficient use of targeted mRNAs in polyribosomes. Here, we identify an enhancement system for ER translation promoted by p180, an integral ER membrane protein we previously reported as an essential factor for the assembly of ER polyribosomes. Read More

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http://dx.doi.org/10.1073/pnas.1901742116DOI Listing

MAPK pathway and B cells overactivation in multiple sclerosis revealed by phosphoproteomics and genomic analysis.

Proc Natl Acad Sci U S A 2019 Apr 19. Epub 2019 Apr 19.

Center of Neuroimmunology, Institut d'Investigacions Biomèdiques August Pi Sunyer, Barcelona 08036, Spain;

Dysregulation of signaling pathways in multiple sclerosis (MS) can be analyzed by phosphoproteomics in peripheral blood mononuclear cells (PBMCs). We performed in vitro kinetic assays on PBMCs in 195 MS patients and 60 matched controls and quantified the phosphorylation of 17 kinases using xMAP assays. Phosphoprotein levels were tested for association with genetic susceptibility by typing 112 single-nucleotide polymorphisms (SNPs) associated with MS susceptibility. Read More

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http://dx.doi.org/10.1073/pnas.1818347116DOI Listing
April 2019
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Dietary calories and lipids synergistically shape adipose tissue cellularity during postnatal growth.

Mol Metab 2019 Apr 5. Epub 2019 Apr 5.

DKFZ Junior Group Metabolism and Stem Cell Plasticity, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg 69120, Germany. Electronic address:

Objective: The susceptibility to abdominal obesity and the metabolic syndrome is determined to a substantial extent during childhood and adolescence, when key adipose tissue characteristics are established. Although the general impact of postnatal nutrition is well known, it is not clear how specific dietary components drive adipose tissue growth and how this relates to the risk of metabolic dysfunction in adulthood.

Methods: Adipose tissue growth including cell proliferation was analyzed in juvenile mice upon dietary manipulation with in vivo nucleotide labeling. Read More

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http://dx.doi.org/10.1016/j.molmet.2019.03.012DOI Listing

Predictive factors of unexpected lymphatic drainage pathways in early-stage cervical cancer.

Gynecol Oncol 2019 Apr 16. Epub 2019 Apr 16.

Gynecologic and Breast Oncologic Surgery Department, Georges Pompidou European Hospital, Paris, France; Paris Descartes University, Sorbonne Paris Cité, Faculty of Medicine, Paris, France.

Objectives: The purpose of this study was to describe sentinel lymph nodes (SLN) topography in patients with early-stage cervical cancer and to determine factors associated with atypical lymphatic drainage pathway (LDP).

Methods: We analyzed the data of two prospective multicentric trials on SLN biopsy for cervical cancer (SENTICOL I and II) in women undergoing surgery for early-stage cervical cancer. SLN detection was realized with a combined labeling technique (Patent blue and radioactive tracer). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00908258193050
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http://dx.doi.org/10.1016/j.ygyno.2019.04.008DOI Listing
April 2019
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Time trends of short-term mortality for octogenarians undergoing a colorectal resection in North Europe.

Eur J Surg Oncol 2019 Apr 9. Epub 2019 Apr 9.

Department of Surgical Oncology, Leiden University Medical Center, the Netherlands. Electronic address:

Background: Decreased cancer specific survival in older colorectal patients is mainly due to mortality in the first year, emphasizing the importance of the first postoperative year. This study aims to gain an overview and time trends of short-term mortality in octogenarians (≥80 years) with colorectal cancer across four North European countries.

Methods: Patients of 80 years or older, operated for colorectal cancer (stage I-III) between 2005 and 2014, were included. Read More

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http://dx.doi.org/10.1016/j.ejso.2019.03.041DOI Listing

The transposition of the Patients' Rights Directive in Finland-Difficulties encountered.

Health Policy 2019 Mar 8. Epub 2019 Mar 8.

Tampere University, Faculty of Social Sciences, P.O. Box 100, 33014, Finland; National Institute for Health and Welfare (THL), Department of Health and Social Care Systems, P.O. Box 30, 00271, Helsinki, Finland. Electronic address:

The Directive on the application on patient rights' in cross-border healthcare (2011/24/EC) was transposed in Finland by the Act on Cross-Border Health Care (1201/2013), which entered into force on 1 January 2014. A new reimbursement model for cross-border health care costs was designed. The Finnish legislator considered the chosen reimbursement model to correspond both with the aims of the Directive as well as to the functioning of the national health care scheme. Read More

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http://dx.doi.org/10.1016/j.healthpol.2019.02.008DOI Listing

Functional Characterization of Clinically-Relevant Rare Variants in Identified in a Gout and Hyperuricemia Cohort.

Cells 2019 Apr 18;8(4). Epub 2019 Apr 18.

Institute of Rheumatology, 128 50 Prague 2, Czech Republic.

ATP-binding cassette subfamily G member 2 (ABCG2) is a physiologically important urate transporter. Accumulating evidence demonstrates that congenital dysfunction of ABCG2 is an important genetic risk factor in gout and hyperuricemia; recent studies suggest the clinical significance of both common and rare variants of ABCG2. However, the effects of rare variants of on the risk of such diseases are not fully understood. Read More

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http://dx.doi.org/10.3390/cells8040363DOI Listing

Sexual Distress in Patients with Hidradenitis Suppurativa: A Cross-Sectional Study.

J Clin Med 2019 Apr 18;8(4). Epub 2019 Apr 18.

Dermatology, Hidradenitis Suppurativa Clinic, Hospital Universitario Virgen de las Nieves, Avenida de las Fuerzas Armadas 2, 18014 Granada, Spain.

Hidradenitis suppurativa (HS) is a chronic auto-inflammatory skin disease with a great impact in quality of life. However, there is little research about the impact of HS on sex life. The aims of this study are to describe the frequency of sexual distress (SD) in patients with HS and to explore potentially associated epidemiological and clinical factors. Read More

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https://www.mdpi.com/2077-0383/8/4/532
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http://dx.doi.org/10.3390/jcm8040532DOI Listing
April 2019
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Reassessment of Viroid RNA Cytosine Methylation Status at the Single Nucleotide Level.

Viruses 2019 Apr 18;11(4). Epub 2019 Apr 18.

Istituto per la Protezione Sostenibile delle Piante (CNR), 70126 Bari, Italy.

Composed of a few hundreds of nucleotides, viroids are infectious, circular, non-protein coding RNAs able to usurp plant cellular enzymes and molecular machineries to replicate and move in their hosts. Several secondary and tertiary RNA structural motifs have been implicated in the viroid infectious cycle, but whether modified nucleotides, such as 5C-methylcytosine (mC), also play a role has not been deeply investigated so far. Here, the possible existence of mC in both RNA polarity strands of potato spindle tuber viroid and avocado sunblotch viroid -which are representative members of the nucleus- and chloroplast-replicating viroids, respectively- has been assessed at single nucleotide level. Read More

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http://dx.doi.org/10.3390/v11040357DOI Listing

Outcome of a Modified Perceval Implantation Technique.

Thorac Cardiovasc Surg 2019 Apr 19. Epub 2019 Apr 19.

Department of Cardiac Surgery, University Hospital Oldenburg, European Medical School Oldenburg-Groningen, Carl von Ossietzky University Oldenburg, Oldenburg, Germany.

Background:  In our institution, we developed a modification of the standard implantation technique of the Perceval sutureless aortic prosthesis (LivaNova, London, United Kingdom) that involves the usage of snuggers for the guiding sutures during valve deployment. The technique has been described elsewhere. In this article, we present the results of our initial case series comprising 128 consecutive patients. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0039-1685512
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http://dx.doi.org/10.1055/s-0039-1685512DOI Listing
April 2019
2 Reads

The widespread increase in inter-individual variability of gene expression in the human brain with age.

Aging (Albany NY) 2019 Apr 19. Epub 2019 Apr 19.

European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, CB10 1SD, UK.

Aging is broadly defined as a time-dependent progressive decline in the functional and physiological integrity of organisms. Previous studies and evolutionary theories of aging suggest that aging is not a programmed process but reflects dynamic stochastic events. In this study, we test whether transcriptional noise shows an increase with age, which would be expected from stochastic theories. Read More

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http://dx.doi.org/10.18632/aging.101912DOI Listing

Does austerity really kill?

Econ Hum Biol 2019 Mar 4;33:211-223. Epub 2019 Mar 4.

Centre for Health Economics, University of York, York, United Kingdom; Luxembourg Institute for Socio-Economic Research, Esch-sur-Alzette/Belval, Luxembourg.

A growing body of the literature has argued that austerity has been bad for health, though without directly measuring austerity. This paper explicitly distinguishes the association of mortality with macroeconomic fluctuations from that with fiscal policy measures, using data for 28 European Union (EU) countries covering the period 1991-2013. The main results present a nuanced, complex picture about the mortality impact of fiscal policies. Read More

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http://dx.doi.org/10.1016/j.ehb.2019.03.002DOI Listing

Association between sarcopenia and diabetes in community dwelling elderly in the Amazon region - Viver Mais Project.

Arch Gerontol Geriatr 2019 Mar 27;83:121-125. Epub 2019 Mar 27.

State University Of Pará, Brazil; Hospital Cynthia Charone, Brazil.

Background: Studies indicate the intrinsic relationship between sarcopenia and diabetes mellitus (DM) pathophysiological mechanisms. Changes in insulin and muscular metabolism are features of diabetic patients and can interact as sarcopenic accelerators. Conversely, sarcopenic patients feature lower glucose tolerance and higher serum insulin levels, predisposing them to DM. Read More

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http://dx.doi.org/10.1016/j.archger.2019.03.020DOI Listing

A comprehensive assessment of stream fragmentation in Great Britain.

Sci Total Environ 2019 Apr 10;673:756-762. Epub 2019 Apr 10.

Department of Biosciences, College of Science, Swansea University, Swansea SA2 8PP, UK.

Artificial barriers are one of the main threats to river ecosystems, resulting in habitat fragmentation and loss of connectivity. Yet, the abundance and distribution of most artificial barriers, excluding high-head dams, is poorly documented. We provide a comprehensive assessment of the distribution and typology of artificial barriers in Great Britain, and estimate for the first time the extent of river fragmentation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00489697193165
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http://dx.doi.org/10.1016/j.scitotenv.2019.04.125DOI Listing
April 2019
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Achievement of low density lipoprotein (LDL) cholesterol targets in primary and secondary prevention: Analysis of a large real practice database in Italy.

Atherosclerosis 2019 Apr 8;285:40-48. Epub 2019 Apr 8.

Hypertension Unit, Division of Cardiology, Department of Clinical and Molecular Medicine, Faculty of Medicine and Psychology, University of Rome Sapienza, Sant'Andrea Hospital, Rome, Italy; IRCCS Neuromed, Pozzilli, IS, Italy. Electronic address:

Background And Aims: Target and intensity of low-density lipoprotein cholesterol (LDL-C) lowering therapy should be tailored according to the individual global cardiovascular (CV) risk. We aimed at retrospectively evaluating real-life LDL-C goal attainment and predictive factors for predefined LDL-C therapeutic goals both in primary and secondary prevention.

Methods: We collected data from a large cohort of outpatients aged 40-65 years, followed by general practitioners, cardiologists and diabetologists in Italy. Read More

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http://dx.doi.org/10.1016/j.atherosclerosis.2019.03.017DOI Listing

Removal efficiency and mass balance of polycyclic aromatic hydrocarbons, phthalates, ethoxylated alkylphenols and alkylphenols in a mixed textile-domestic wastewater treatment plant.

Sci Total Environ 2019 Apr 10;674:36-48. Epub 2019 Apr 10.

Department of Chemistry, University of Florence, Via della Lastruccia 3, 50019 Sesto Fiorentino, Florence, Italy. Electronic address:

In this work the occurrence and fate of polycyclic aromatic hydrocarbons (PAHs), phthalic acid esters (PAEs), mono and diethoxylate alkylphenols (APEOs) and alkylphenols (APs) have been investigated during a two-weeks period in a facility treating mixed textile-domestic wastewater (Prato, Italy). The wastewater treatment plant (WWTP) consists of primary sedimentation, activated sludge biological oxidation, secondary sedimentation, clariflocculation and ozonation. The sludge is treated within the facility by thickening, dewatering and final incineration, thus providing the almost quantitative removal of the adsorbed micropollutants. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00489697193161
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http://dx.doi.org/10.1016/j.scitotenv.2019.04.096DOI Listing
April 2019
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Determinants of phthalate exposure and risk assessment in children from Poland.

Environ Int 2019 Apr 16;127:742-753. Epub 2019 Apr 16.

Department of Environmental Epidemiology, Nofer Institute of Occupational Medicine (NIOM), Lodz, Poland.

Phthalates are a group of widely used chemicals and humans are exposed to them in their daily life. Some phthalates may affect the hormonal balance in both children and adults. The aim of this study was to assess the phthalate exposure and its determinants among children at age of 7 years from the Polish Mother and Child Cohort Study (REPRO_PL). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01604120193065
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http://dx.doi.org/10.1016/j.envint.2019.04.011DOI Listing
April 2019
1 Read

[Prophylactic hysterectomy in Lynch syndrome: feasibility and outcomes].

Gynecol Obstet Fertil Senol 2019 Apr 16. Epub 2019 Apr 16.

Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges-Pompidou, Chirurgie Cancérologique Gynécologique et du Sein, Paris, France; Université Paris Descartes, INSERM UMR-S 747, Paris, France; Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine, Paris, France. Electronic address:

Objectives: Lynch syndrome (LS) is a hereditary predisposition to cancers, first of all, colo-rectal and endometrial cancers in women. Although recommended, gynecologic screening has never proven its benefit. Prophylactic surgery can be consider once the parental project is completed. Read More

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http://dx.doi.org/10.1016/j.gofs.2019.04.010DOI Listing

Microsatellite markers reveal two genetic groups in European populations of the carrot cyst nematode Heterodera carotae.

Infect Genet Evol 2019 Apr 16. Epub 2019 Apr 16.

IGEPP, INRA, Agrocampus-Ouest, Université de Rennes 1, 35650, Le Rheu, France.

The cyst nematode Heterodera carotae, which parasitizes carrot roots, has been recorded in many countries in Europe (Italy, The Netherlands, Switzerland, France, Denmark, …), in South Africa and in North America (Canada, USA). To date, there is a lack of knowledge about the genetic structure of the populations of this economically important nematode. The aim of this work was to study the structuration of the genetic diversity of the carrot cyst nematode at the European scale. Read More

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http://dx.doi.org/10.1016/j.meegid.2019.04.011DOI Listing

Mother-infant interactions with firstborns and secondborns: A within-family study of European Americans.

Infant Behav Dev 2019 Apr 16;55:100-111. Epub 2019 Apr 16.

Institute for Fiscal Studies, London, UK.

Given the large numbers of families with more than one child, understanding similarities and differences in siblings' behaviors and in parents' interactions with their sibling infants is an important goal for advancing more representative developmental science. This study employed a within-family design to examine mean-level consistency and individual-order agreement in 5-month-old sibling behaviors and maternal parenting practices with their firstborns and secondborns (ns = 61 mothers and 122 infants). Each infant was seen independently with mother. Read More

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http://dx.doi.org/10.1016/j.infbeh.2019.03.009DOI Listing

The frequency of referent objects influences expectations about label length.

Authors:
Tibor Tauzin

Acta Psychol (Amst) 2019 Apr 16;196:70-74. Epub 2019 Apr 16.

Cognitive Science Department, Central European University, Október 6. u. 7, H-1051 Budapest, Hungary. Electronic address:

Earlier studies suggest that word length is influenced by the linguistic context to be precise and concise at the same time. The present study investigates whether the referential-situational context can also have an effect on the expected length of words. To test this assumption a salient property of the situational context, that is, the frequency of the unfamiliar referents was varied. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00016918183049
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http://dx.doi.org/10.1016/j.actpsy.2019.04.010DOI Listing
April 2019
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The new US and European guidelines in hypertension: A multi-dimensional analysis.

Contemp Clin Trials 2019 Apr 16. Epub 2019 Apr 16.

Medbase, Chapel Hill, NC, USA.

The Systolic Blood Pressure Intervention Trial (SPRINT) compared the clinical outcomes between target systolic blood pressure (SBP) levels between 140 and 120 mmHg or lower. Both,the 2017 ACC/AHA and the 2018 ESC/ESH guidelines in hypertension are derived from the SPRINT trial and advise initiation and/or intensification of treatment at lower blood pressure thresholds. The ACC/AHA guidance supersedes the 2014 Eight Joint National Committee guideline (JNC-8) which advised initiation of treatment when the BP was 140/90 mmHg or higher; in adults 60 years or over, the target was 150/90 mmHg. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15517144183071
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http://dx.doi.org/10.1016/j.cct.2019.04.008DOI Listing
April 2019
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Antibacterial free-standing polysaccharide composite films inspired by the sea.

Int J Biol Macromol 2019 Apr 16. Epub 2019 Apr 16.

3B's Research Group, I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, 4805-017 Barco, Guimarães, Portugal; ICVS/3B's PT Associate Laboratory, Guimarães, Portugal. Electronic address:

The adhesive capabilities of marine mussel proteins are well-known, exhibiting the ability to stick to different underwater substrates, either inorganic or organic. These unique adhesive properties are due to the high levels of amino acid, 3,4-dihydroxyphenyl-l-alanine (DOPA), which presents the reactive catechol group. Herein, novel antibacterial free-standing (FS) films were developed with natural polymers, namely chitosan (CHT) and hyaluronic acid (HA), being the catechol-functionalized hyaluronic acid (HA-DN) also included to provide wet adhesive properties. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01418130193042
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http://dx.doi.org/10.1016/j.ijbiomac.2019.04.102DOI Listing
April 2019
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Semen quality is affected by HLA class I alleles together with sexually transmitted diseases.

Andrology 2019 Apr 19. Epub 2019 Apr 19.

Instituto de Investigação e Inovação em Saúde, Universidade do Porto (i3S), Porto, Portugal.

Background: The human leukocyte antigen (HLA) locus includes several genes with key roles in antigen presentation and immune response, some of them inclusively found to be associated with non-obstructive azoospermia. Still, HLA connections to other infertility phenotypes such as semen hyperviscosity (SHV), asthenozoospermia (AST), and oligozoospermia (OLI) have been often neglected.

Objectives: In this work, we aimed to evaluate the association of HLA class I and II genes with SHV, AST, and OLI phenotypes while exploring a possible role in an adaptive immune response to sexually transmitted diseases (STD). Read More

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http://dx.doi.org/10.1111/andr.12625DOI Listing

Commentary to the paper: The effectiveness of self-management interventions in adults with chronic orofacial pain: A systematic review, Meta-analysis and Meta-regression. European Journal of Pain.

Authors:
M Ferrando

Eur J Pain 2019 Apr 19. Epub 2019 Apr 19.

Kveloce I+D+i Research Consultancy.

The current issue includes a paper by Aggarwal et al (2019), entitled "The effectiveness of self-management interventions in adults with chronic orofacial pain: A Systematic review, Meta-analysis and Meta-regression". The paper is very relevant for both research and evidenced-based practice, since it presents a comprehensive overview of existing published findings on self-management programmes in chronic orofacial pain. This article is protected by copyright. Read More

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http://dx.doi.org/10.1002/ejp.1401DOI Listing

Endovascular Treatment for Acute Ischemic Stroke: Clinical Outcomes Under Pressure.

Eur J Neurol 2019 Apr 19. Epub 2019 Apr 19.

Second Department of Neurology, "Attikon" University Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.

Current guidelines from the European Stroke Organisation (ESO) and the European Society for Minimally Invasive Neurological Therapy (ESMINT) on the endovascular treatment (EVT) for large vessel occlusion (LVO) patients with acute ischemic stroke (AIS) suggest to maintain blood pressure (BP) levels below 180/105 mmHg both during and for 24 hours after EVT, however grading this recommendation as weak due to the low quality of existing evidence. The association between functional outcomes following EVT and the various BP parameters, measured hourly during the first 24 hours after admission, was further investigated in the retrospective analysis of 378 LVO patients by Cho et al. This article is protected by copyright. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/ene.13969
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http://dx.doi.org/10.1111/ene.13969DOI Listing
April 2019
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The use of aminoglycosides in animals within the EU: development of resistance in animals and possible impact on human and animal health: a review.

J Antimicrob Chemother 2019 Apr 19. Epub 2019 Apr 19.

Veterinary Medicines Directorate, Addlestone, UK.

Aminoglycosides (AGs) are important antibacterial agents for the treatment of various infections in humans and animals. Following extensive use of AGs in humans, food-producing animals and companion animals, acquired resistance among human and animal pathogens and commensal bacteria has emerged. Acquired resistance occurs through several mechanisms, but enzymatic inactivation of AGs is the most common one. Read More

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http://dx.doi.org/10.1093/jac/dkz161DOI Listing

Asymmetrical, Symmetrical, Divalent, and Y-Shaped (Bola)amphiphiles: The Relationship between the Molecular Structure and Self-Assembly in Amino Derivatives of Sophorolipid Biosurfactants.

J Phys Chem B 2019 Apr 19. Epub 2019 Apr 19.

Laboratory for Chemical Technology (LCT), Department of Materials, Textiles and Chemical Engineering , Ghent University , Technologiepark 125 , 9052 Ghent , Belgium.

Conventional head-chain but also more exotic divalent, Gemini, or bolaform amphiphiles have in common well-defined hydrophilic and hydrophobic blocks with often a predictable self-assembly behavior. However, new categories of amphiphiles, such as microbial biosurfactants, challenge such conventional understanding because of the poorly defined boundaries between the hydrophilic and hydrophobic portions. Microbial glycolipids, such as sophorolipids, rhamnolipids, or cellobioselipids, interesting biodegradable, nontoxic, alternatives to synthetic surfactants, all represent interesting examples of atypical amphiphiles with partially predictable self-assembly properties. Read More

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http://dx.doi.org/10.1021/acs.jpcb.9b01013DOI Listing

Atopic Eczema: Burden of disease and individual suffering - Results from a large EU-Study in adults.

J Eur Acad Dermatol Venereol 2019 Apr 19. Epub 2019 Apr 19.

European Federation of Allergy and Airway Diseases Patient's Associations, Brussels, Belgium.

Background: Atopic eczema (AE, atopic dermatitis) is one the most common non-communicable inflammatory skin diseases affecting 1-5% of the adult population in Europe with marked impairment in quality of life. In spite of great progress in understanding the pathophysiology of disturbed skin barrier and immune deviation, AE still represents a problem in daily clinical practice. Furthermore, the true impact of AE on individual suffering is often not recognized. Read More

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http://dx.doi.org/10.1111/jdv.15634DOI Listing

Contrasting effects of host species and phylogenetic diversity on the occurrence of HPAI H5N1 in European wild birds.

J Anim Ecol 2019 Apr 19. Epub 2019 Apr 19.

Resource Ecology Group, Wageningen University, 6708PB, Wageningen, The Netherlands.

Studies on the highly pathogenic avian influenza (HPAI) H5N1 suggest that wild bird migration may facilitate its long-distance spread, yet the role of wild bird community composition in its transmission risk remains poorly understood. Furthermore, most studies on the diversity-disease relationship focused on host species diversity without considering hosts' phylogenetic relationships, which may lead to rejecting a species diversity effect when the community has host species that are only distantly related. Here, we explored the influence of waterbird community composition for determining HPAI H5N1 occurrence in wild birds in a continental-scale study across Europe. Read More

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http://dx.doi.org/10.1111/1365-2656.12997DOI Listing