297,195 results match your criteria European journal of obstetrics gynecology and reproductive biology[Journal]


Sarcopenia and variation in the Human Leukocyte Antigen complex.

J Gerontol A Biol Sci Med Sci 2019 Feb 17. Epub 2019 Feb 17.

Epidemiology and Public Health Group, University of Exeter Medical School, RILD Building, Barrack Road, Exeter, UK.

Background: Aging is characterized by chronic inflammation plus muscle mass and strength loss, termed sarcopenia. Human Leukocyte Antigen (HLA) types are drivers of autoimmune disease, although with limited penetrance. We tested whether autoimmune diagnoses are associated with sarcopenia, and whether HLA types and related genetic variants associate with sarcopenia in autoimmune disease free older people. Read More

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http://dx.doi.org/10.1093/gerona/glz042DOI Listing
February 2019

Lung Cancer App (LuCApp) study protocol: a randomised controlled trial to evaluate a mobile supportive care app for patients with metastatic lung cancer.

BMJ Open 2019 Feb 15;9(2):e025483. Epub 2019 Feb 15.

Centre for Research in Health and Social Care Management (CERGAS), SDA Bocconi, Milano, Italy.

Introduction: Mobile health technologies may enhance patient empowerment and data integration along the whole care continuum. However, these interventions pose relatively new regulatory, organisational and technological challenges that limit appropriate evaluation. Lung Cancer App (LuCApp) is a mobile application developed by researchers and clinicians to promote real-time monitoring and management of patients' symptoms. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-025483DOI Listing
February 2019

Impact of gene-specific germline pathogenic variants on presentation of endometrial cancer in Lynch syndrome.

Int J Gynecol Cancer 2019 Feb 16. Epub 2019 Feb 16.

Department of Gynecologic Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milano, Italy.

Objective: Lynch syndrome is a risk factor for developing endometrial carcinoma. Our aim was to evaluate the impact of gene-specific germline pathogenic variants on clinical features of patients affected by endometrial cancer.

Methods: Patients with a diagnosis of endometrial cancer and with a germline pathogenic variant in mismatch repair genes were reviewed. Read More

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http://dx.doi.org/10.1136/ijgc-2019-000277DOI Listing
February 2019

Development of the LC-MS/MS method for determining the p-cresol level in plasma.

J Pharm Biomed Anal 2019 Jan 31;167:149-154. Epub 2019 Jan 31.

Department of Bioanalysis and Drugs Analysis, Faculty of Pharmacy with the Laboratory Medicine Division, Medical University of Warsaw, 1 Banacha Street, 02-097 Warsaw, Poland. Electronic address:

p-Cresol is a protein-bound uremic retention solute that originates in the intestine through bacterial metabolism and accumulates throughout the body in case of kidney failure. To date, there has been no method to analyze unconjugated p-cresol concentration in the blood with a limit of detection lower than 75 pg. Thus, the aim of this study was to develop and validate a novel liquid chromatography-tandem mass spectrometry method for the determination of unconjugated p-cresol in plasma with a lower detection limit than what has been determined using previously described methods. Read More

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http://dx.doi.org/10.1016/j.jpba.2019.01.041DOI Listing
January 2019

Reduced response to gabapentin enacarbil in restless legs syndrome following long-term dopaminergic treatment.

Sleep Med 2018 Dec 26;55:74-80. Epub 2018 Dec 26.

European Sleep Institute, Santiago, Chile. Electronic address:

Objectives: To determine whether long-term treatment with dopaminergic agents (DAs) might dampen the response to a non-dopaminergic agent, such as gabapentin enacarbil.

Methods: We performed a two-week randomized, double-blind, crossover, and placebo-controlled study in a single, referral center in dopamine treatment-naive patients and non-augmented patients continuously treated with dopaminergics for the last five consecutive years. Following washout from any previous CNS-active drugs, patients were randomized into one of two groups for two consecutive two-week treatment periods with gabapentin enacarbil (GBPen) and placebo. Read More

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http://dx.doi.org/10.1016/j.sleep.2018.11.025DOI Listing
December 2018

ACCELERATE and European Medicine Agency Paediatric Strategy Forum for medicinal product development for mature B-cell malignancies in children.

Eur J Cancer 2019 Feb 14;110:74-85. Epub 2019 Feb 14.

Department of Clinical Research, Gustave Roussy, Paris-Sud University, Paris, France.

Paediatric Strategy Forums have been created by the multistakeholder organisation, ACCELERATE, and the European Medicines Agency to facilitate dialogue between all relevant stakeholders and suggest strategies in critical areas of paediatric oncology drug development. As there are many medicines being developed for B-cell malignancies in adults but comparatively few in children with these malignancies, a Paediatric Strategy Forum was held to discuss the best approach to develop these products for children. It was concluded that as current frontline therapy is highly successful, despite associated acute toxicity, de-escalation of this or substitution of presently used drugs with new medicines can only be undertaken when there is an effective salvage regimen, which is currently not available. Read More

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http://dx.doi.org/10.1016/j.ejca.2019.01.013DOI Listing
February 2019

A tale of shells and claws: The signal crayfish as a threat to the pearl mussel Margaritifera margaritifera in Europe.

Sci Total Environ 2019 Feb 7;665:329-337. Epub 2019 Feb 7.

Centro de Investigação de Montanha (CIMO), Instituto Politécnico de Bragança, Campus de Santa Apolónia, 5300-253 Bragança, Portugal.

The freshwater pearl mussel Margaritifera margaritifera is a highly threatened species in Europe. Several mechanisms may be responsible for the decline in distribution and abundance of European pearl mussel populations, but almost no quantitative data exists about the possible negative impacts of invasive alien species (IAS). In this study, we clearly demonstrate that the invasive signal crayfish Pacifastacus leniusculus predates pearl mussels, using a laboratorial experiment followed by in situ validation in four rivers in the North of Portugal (Mente, Rabaçal, Tuela and Baceiro Rivers; Douro Basin). Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.02.094DOI Listing
February 2019

Effects of boom and bust grazing management on vegetation and health of beef cattle used for wildfire prevention in a Mediterranean forest.

Sci Total Environ 2019 Feb 4;665:18-22. Epub 2019 Feb 4.

Departamento de Biología Animal, Biología Vegetal y Ecología, Botánica, Universidad Autónoma de Barcelona (UAB), Bellaterra, 08193 Barcelona, Spain; CREAF, Cerdanyola del Vallès, 08193 Barcelona, Spain. Electronic address:

Humans and wildfires have historically driven landscape structure in the Mediterranean basin. The Iberian Peninsula is not an exception to that rule, and therefore, farmers, researchers, and governments seek alternative tools to minimize the loss of biodiversity and wildfire risks. Extensive livestock including beef cattle is currently promoted as a suitable management tool by European agro-environmental policies yet pieces of evidence exist regarding the reciprocal effects between cows and Mediterranean woody vegetation. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.02.037DOI Listing
February 2019

The European registry on obstetric Antiphospholipid syndrome (EUROAPS): A survey of 1000 consecutive cases.

Autoimmun Rev 2019 Feb 14. Epub 2019 Feb 14.

Obstetrics and Gynaecology Department, High Risk Unit, Vall d'Hebron University Hospital, Universitat Autonoma, Barcelona, Spain.

Aim To analyse the clinical features, laboratory data and foetal-maternal outcomes, and follow them up on a cohort of 1000 women with obstetric antiphospholipid syndrome (OAPS).

Methods: The European Registry of OAPS became a registry within the framework of the European Forum on Antiphospholipid Antibody projects and was placed on a website in June 2010. Thirty hospitals throughout Europe have collaborated to carry out this registry. Read More

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http://dx.doi.org/10.1016/j.autrev.2018.12.006DOI Listing
February 2019

Essential Research Priorities in Renal Cancer: A Modified Delphi Consensus Statement.

Eur Urol Focus 2019 Feb 13. Epub 2019 Feb 13.

Department of Surgery, University of Cambridge, Addenbrooke's Hospital, Cambridge Biomedical Campus, Cambridge, UK. Electronic address:

Background: Identification of clear and focused research priorities is crucial to drive research forward.

Objective: To identify research priorities in renal cell carcinoma (RCC) through a multidisciplinary collaboration between clinicians, researchers, and patients.

Design, Setting, And Participants: In phase I, 44 RCC experts provided 24 literature reviews within their field, summarising research gaps (RGs). Read More

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http://dx.doi.org/10.1016/j.euf.2019.01.014DOI Listing
February 2019

Cephalometric norms of a Burkina Faso population.

Int Orthod 2019 Feb 13. Epub 2019 Feb 13.

Institut d'odontostomatologie de Dakar, Dakar, Senegal.

Introduction: After a clinical examination, in order to implement an appropriate treatment planning, additional examinations such as lateral cephalograms, were performed. They were submitted to a cephalometric analysis such as the Tweed-Merrifield analysis. These cephalometric analyses based on a synthesis of aesthetic criteria established for a Caucasian European-American white people population could not serve as the reference for an African population. Read More

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http://dx.doi.org/10.1016/j.ortho.2019.01.002DOI Listing
February 2019

European College of Orthodontics. Commission of affiliation and titularisation. Case No. 17043.

Int Orthod 2019 Feb 13. Epub 2019 Feb 13.

C/San Bartolome10-2°, 20007 San Sebastian, Spain. Electronic address:

Date of birth: 4/02/97; gender: female.

Pre-treatment Documents: 13.7 years old; 09/2010. Read More

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http://dx.doi.org/10.1016/j.ortho.2019.01.015DOI Listing
February 2019

THE SMALL FATAL CHOROIDAL MELANOMA STUDY A Survey by the European Ophthalmic Oncology Group.

Am J Ophthalmol 2019 Feb 14. Epub 2019 Feb 14.

Ocular Oncology Service, Department of Ophthalmology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Purpose: To determine the size at which choroidal melanomas can metastasize and to report the characteristics of small fatal choroidal melanomas (SFCM).

Design: Retrospective case series.

Methods: Ten ocular oncology services submitted 45 patients with a choroidal melanoma 3 mm or less in thickness and 9 mm or less in largest basal diameter (LBD), when treated, who developed metastases. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.01.031DOI Listing
February 2019

General and abdominal adiposity and the risk of Parkinson's disease: A prospective cohort study.

Parkinsonism Relat Disord 2019 Feb 8. Epub 2019 Feb 8.

Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Germany. Electronic address:

Introduction: Due to demographic change, an increase in the frequency of Parkinson's disease (PD) patients is expected in the future and, thus, the identification of modifiable risk factors is urgently needed. We aimed to examine the associations of body mass index (BMI) and waist circumference (WC) with incident PD.

Methods: In 13 of the 23 centers of the European Prospective Investigation into Cancer and Nutrition (EPIC) study, a total of 734 incident cases of PD were identified between 1992 and 2012 with a mean follow-up of 12 years. Read More

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http://dx.doi.org/10.1016/j.parkreldis.2019.01.019DOI Listing
February 2019

Ten-year follow-up of unreplaced Valsalva sinuses after aortic valve replacement in bicuspid aortic valve disease.

Arch Cardiovasc Dis 2019 Feb 13. Epub 2019 Feb 13.

Department of Cardiovascular Surgery, Georges Pompidou European Hospital, AP-HP, 75015 Paris, France; School of Medicine, Paris Descartes University, Sorbonne Paris Cité, 75006 Paris, France.

Background: Aortopathy is common in patients with bicuspid aortic valve (BAV).

Aim: To evaluate the fate of unreplaced Valsalva sinuses in patients with BAV, 10 years after aortic valve replacement (AVR) with or without replacement of the ascending aorta (RAA).

Methods: We retrospectively reviewed all surgical patients with BAV who were operated on between January 2005 and December 2007. Read More

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http://dx.doi.org/10.1016/j.acvd.2018.11.014DOI Listing
February 2019

Validity of hepatitis B and hepatitis C case definitions.

J Infect Public Health 2019 Feb 13. Epub 2019 Feb 13.

Institute for Global Health and Development, Queen Margaret University Edinburgh, Scotland, United Kingdom. Electronic address:

Background: Globally, an estimated 257 million people are living with chronic hepatitis B (HBV) infection and an estimated 71 million people with the chronic hepatitis C virus (HCV). The true public health dimensions and impact of hepatitis epidemics are poorly understood. Case definitions are fundamental parts of disease surveillance, representing sets of standardised criteria used to assess whether or not a person has a certain disease. Read More

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http://dx.doi.org/10.1016/j.jiph.2019.01.061DOI Listing
February 2019

Etiologic Evaluation of Ischemic Stroke in Young Adults: A Comparative Study between Two European Centers.

J Stroke Cerebrovasc Dis 2019 Feb 13. Epub 2019 Feb 13.

Faculdade de Medicina da Universidade de Lisboa, Lisboa, Portugal; Department of Neurosciences and Mental Health, Service of Neurology, Hospital Santa Maria-CHLN, Universidade de Lisboa, Lisboa, Portugal.

Introduction: Identifying the cause of ischemic stroke in young adults is often difficult. Our objective was to compare the etiologic diagnostic strategy for ischemic stroke in young adults between 2 European centers and investigate the influence of workup variations in the diagnosed etiologies.

Patients And Methods: We included patients aged 18-55 years admitted for ischemic stroke or transient ischemic attack to the stroke units of Santa Maria Hospital in Lisbon, Portugal, and Innsbruck University Hospital in Innsbruck, Austria, between 2014 and 2016. Read More

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2019.01.019DOI Listing
February 2019

Internal exposure of young German adults to di(2-propylheptyl) phthalate (DPHP): Trends in 24-h urine samples from the German Environmental Specimen Bank 1999-2017.

Int J Hyg Environ Health 2019 Feb 13. Epub 2019 Feb 13.

German Environment Agency (UBA), Corrensplatz 1, 14195 Berlin, Germany.

Di(2-propylheptyl) phthalate (DPHP) is used as a substitute for high molecular weight phthalates like di(2-ethylhexyl) phthalate (DEHP) which were subjected to authorization under REACh in 2015. An earlier study on the time trend of exposure in human 24-h urine samples from the German Environmental Specimen Bank has revealed that metabolites of DPHP emerged in 2009 and 2012 (Schütze et al., 2015). Read More

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http://dx.doi.org/10.1016/j.ijheh.2018.12.008DOI Listing
February 2019

Prenatal diagnosis and management of congenital diaphragmatic hernia.

Best Pract Res Clin Obstet Gynaecol 2019 Jan 5. Epub 2019 Jan 5.

Academic Department of Development and Regeneration, Cluster Woman and Child, Biomedical Sciences, KU Leuven, Belgium; Clinical Department of Obstetrics & Gynaecology, KU Leuven, Leuven, Belgium; Institute for Women's Health, University College London, London, UK; European Reference Network on Rare and Inherited Congenital Anomalies "ERNICA". Electronic address:

Congenital diaphragmatic hernia is characterized by failed closure of the diaphragm, thereby allowing abdominal viscera to herniate into the thoracic cavity and subsequently interfering with normal lung development. At birth, pulmonary hypoplasia leads to respiratory insufficiency and persistent pulmonary hypertension (PHT), that is lethal in up to 32% of patients. In isolated cases, the outcome may be predicted prenatally by medical imaging and advanced genetic testing. Read More

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http://dx.doi.org/10.1016/j.bpobgyn.2018.12.010DOI Listing
January 2019

Nonmedical prescription psychiatric drug use and the darknet: A cryptomarket analysis.

Int J Drug Policy 2019 Feb 12. Epub 2019 Feb 12.

Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, United Kingdom.

Background: Nonmedical prescription psychiatric drug use (NMPDU) is an increasing global health problem, with recent concern focusing on darknet cryptomarkets as sources of procurement. There is a shortage of evidence regarding comparative worldwide NMPDU trends, due in part to data collection difficulties. This problem is particularly marked for non-opioid drugs, particularly those psychiatric drugs which act on the central nervous system (CNS) and have high misuse potential and are associated with high levels of dependency and fatal overdose. Read More

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http://dx.doi.org/10.1016/j.drugpo.2019.01.016DOI Listing
February 2019

Nutrition education in medical schools (NEMS). An ESPEN position paper.

Clin Nutr 2019 Feb 7. Epub 2019 Feb 7.

Department of Gastroenterology and Nutritional Support, Hopital Erasme and Institut Bordet, Free University of Brussels, Brussels, Belgium.

Background & Aims: Nutrition education is necessary in the training of healthcare professionals, including medical students. However, recent surveys showed that there is a high variability within Medical Schools in different countries. The aim of this ESPEN position paper is to identify a minimum curriculum knowledge in nutrition that serves to improve the training of the future doctors and how to solve the main barriers of its implementation in university centres. Read More

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http://dx.doi.org/10.1016/j.clnu.2019.02.001DOI Listing
February 2019

The impact and evolution of acute-on-chronic liver failure in decompensated cirrhosis: A Portuguese single-center study.

Gastroenterol Hepatol 2019 Feb 13. Epub 2019 Feb 13.

Gastroenterology Department, Hospital Professor Doutor Fernando Fonseca, Amadora, Portugal.

Introduction: Acute-on-chronic liver failure (ACLF) is a dynamic syndrome that should be assessed repeatedly. An algorithm for risk stratification in decompensated cirrhosis was recently proposed by the EASL-CLIF (European Association for the Study of the Liver-Chronic Liver Failure) Consortium.

Aim: To validate the EASL-CLIF Consortium scores in patients with and without ACLF. Read More

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http://dx.doi.org/10.1016/j.gastrohep.2018.11.007DOI Listing
February 2019

End-of-Life Decisions 20 Years after EURONIC: Neonatologists' Self-Reported Practices, Attitudes, and Treatment Choices in Germany, Switzerland, and Austria.

J Pediatr 2019 Feb 13. Epub 2019 Feb 13.

Department of Neonatology, Charité-Universitätsmedizin Berlin, Berlin, Germany.

Objective: To assess changes in attitudes of neonatologists regarding the care of extremely preterm infants and parental involvement over the last 20 years.

Study Design: Internet-based survey (2016) involving 170 tertiary neonatal intensive care units in Austria, Switzerland, and Germany using the European Project on Parents' Information and Ethical Decision Making in Neonatal Intensive Care Units questionnaire (German edition) with minor modifications to the original survey from 1996 to 1997.

Results: The 2016 survey included 104 respondents (52. Read More

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http://dx.doi.org/10.1016/j.jpeds.2018.12.064DOI Listing
February 2019

Electrochemical aptasensor for ampicillin detection based on the protective effect of aptamer-antibiotic conjugate towards DpnII and Exo III digestion.

Talanta 2019 May 4;197:42-48. Epub 2019 Jan 4.

College of Chemistry and Material Science, Shandong Agricultural University, 271018 Tai'an, Shandong, PR China.

A simple and sensitive electrochemical method was developed for ampicillin detection based on the protective effect of aptamer-antibiotic conjugate towards endonuclease DpnII activity. Without ampicillin, DNA aptamer firstly hybridizes with the capture probe to form double strand DNA (dsDNA) structure. Then, dsDNA is cleaved by DpnII restriction endonuclease to form two dsDNA fragments. Read More

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http://dx.doi.org/10.1016/j.talanta.2019.01.010DOI Listing
May 2019
1 Read

Ready for Germany's revised radiation rules?

Authors:
Manfred Kurz

Crit Rev Oncol Hematol 2019 Feb 6;134:82-86. Epub 2018 Dec 6.

Regulatory Strategy Department - H. Lundbeck A/S, Ottiliavej 9, 2500 Valby, Denmark. Electronic address:

The assessment of the benefit-risk ratio of investigational medicinal products (IMPs) and the approval of clinical trial applications (CTAs) conducted in the European Union (EU) is a remit of national competent authorities (NCAs) of the 28 member states. The aim of this article is to shed light on clinical studies for oncology drugs carried out in Germany which involve diagnostic radiation tests. The authorisation process surrounding diagnostic radiology accompanying clinical investigations and used for measuring IMP related treatment effects is not well understood. Read More

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http://dx.doi.org/10.1016/j.critrevonc.2018.11.012DOI Listing
February 2019

The risk of extra-ovarian malignancies among women with endometriosis: A systematic literature review and meta-analysis.

Crit Rev Oncol Hematol 2019 Feb 9;134:72-81. Epub 2019 Jan 9.

Cancer Risk Factors and Lifestyle Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy. Electronic address:

We conducted a meta-analysis of studies reporting on the risk of extra-ovarian malignancies among women with endometriosis. Summary relative risk (SRR) and 95% confidence intervals (CI) were calculated through random effect models. We explored causes of between-studies heterogeneity and assessed the presence of publication bias. Read More

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http://dx.doi.org/10.1016/j.critrevonc.2018.12.009DOI Listing
February 2019

The clinical use of circulating tumor cells (CTCs) enumeration for staging of metastatic breast cancer (MBC): International expert consensus paper.

Crit Rev Oncol Hematol 2019 Feb 19;134:39-45. Epub 2018 Dec 19.

Department of Tumor Biology, Center of Experimental Medicine, University Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Background: The heterogeneity of metastatic breast cancer (MBC) necessitates novel biomarkers allowing stratification of patients for treatment selection and drug development. We propose to use the prognostic utility of circulating tumor cells (CTCs) for stratification of patients with stage IV disease.

Methods: In a retrospective, pooled analysis of individual patient data from 18 cohorts, including 2436 MBC patients, a CTC threshold of 5 cells per 7. Read More

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http://dx.doi.org/10.1016/j.critrevonc.2018.12.004DOI Listing
February 2019

Integration of GWAS and brain eQTL identifies FLOT1 as a risk gene for major depressive disorder.

Neuropsychopharmacology 2019 Feb 16. Epub 2019 Feb 16.

Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, 650223, Kunming, Yunnan, China.

Major depressive disorder (MDD) is the most prevalent mental disorder that affects more than 200 million people worldwide. Recent large-scale genome-wide association studies (GWAS) have identified multiple risk variants that show robust association with MDD. Nevertheless, how the identified risk variants confer risk of MDD remains largely unknown. Read More

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http://dx.doi.org/10.1038/s41386-019-0345-4DOI Listing
February 2019
1 Read

Integrative analyses of major histocompatibility complex loci in the genome-wide association studies of major depressive disorder.

Neuropsychopharmacology 2019 Feb 16. Epub 2019 Feb 16.

Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.

Recent European genome-wide association studies (GWAS) have revealed strong statistical correlations between MDD and numerous zero-to-high linked variants in the genomic region containing major histocompatibility complex (MHC) genes (MHC region), but the underlying molecular mechanisms are still unclear. To better understand the roles of this genomic region in the neurobiology of MDD, we applied a convergent functional genomics approach to integrate GWAS data of MDD relevant biological phenotypes, gene-expression analyses results obtained from brain samples, and genetic analyses of independent Chinese MDD samples. We observed that independent MDD risk variants in the MHC region were also significantly associated with the relevant biological phenotypes in the predicted directions, including the emotional and cognitive-related phenotypes. Read More

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http://dx.doi.org/10.1038/s41386-019-0346-3DOI Listing
February 2019

Fate and removal of trace pollutants from an anion exchange spent brine during the recovery process of natural organic matter and salts.

Water Res 2019 Feb 4;154:34-44. Epub 2019 Feb 4.

University of Twente, Faculty of Science and Technology, De Horst 2, 7522LW, Enschede, the Netherlands; Oasen NV, Nieuwe Gouwe O.Z. 3, 2801 SB, Gouda, the Netherlands.

The results of this sampling campaign on pilot scale processes aim to evaluate the occurrence and behavior of trace organic micro-pollutants and metal elements during anion exchange treatment of surface water and the subsequent treatment of generated spent brine with two types of electrodialysis membrane pairs. This knowledge is relevant to assess the quality and reusability of secondary products created during brine treatment; specifically the excess of sodium chloride to be recycled onsite and the natural organic matter, mostly consisting of humic substances, which find multiple applications in the agricultural industry. This study highlights that (1) the attachment mechanism of organic micro-pollutants to anion exchange resin occurs through electrostatic interaction and the subsequent transfer through ion exchange membranes is restricted by size exclusion; and (2) the complexation of trace metals compounds with the natural organic matter partly explains their removal by anion exchange. Read More

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http://dx.doi.org/10.1016/j.watres.2019.01.042DOI Listing
February 2019

Contemporary trends of pelvic lymph node dissection at radical cystectomy for urothelial carcinoma of urinary bladder and associated cancer specific mortality and complications: comparison between octogenarian versus younger patients.

Cancer Epidemiol 2019 Feb 13;59:135-142. Epub 2019 Feb 13.

Cancer Prognostics and Health Outcomes Unit, University of Montreal Health Center, Montreal, Québec, Canada; Division of Urology, University of Montreal Hospital Center (CHUM), Montreal, Quebec, Canada.

Background: We analysed contemporary pelvic lymph node dissection (PLND) trend during radical cystectomy (RC) for urothelial carcinoma of urinary bladder (UCUB), as well as PLND association with cancer specific mortality (CSM) and complications after stratification according to octogenarian vs. younger age.

Materials And Methods: Within the SEER and NIS databases, respectively 10,427 (T2 and T3 stages) and 19,203 (all T-stages) RC patients (2004-2015) for UCUB were identified. Read More

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http://dx.doi.org/10.1016/j.canep.2019.02.002DOI Listing
February 2019

Prospective Clinical Trial Comparing Trapezial Denervation With Trapeziectomy for the Surgical Treatment of Arthritis at the Base of the Thumb.

J Surg Res 2019 Feb 13;238:144-151. Epub 2019 Feb 13.

The Pulvertaft Hand Surgery Centre, Royal Derby Hospital, Derby, United Kingdom.

Background: Trapeziectomy is considered to be the "gold standard" procedure for first carpometacarpal joint (first CMCJ) osteoarthritis. First CMCJ denervation offers the potential benefit of a shorter procedure with bone and joint preservation and swift postoperative rehabilitation. This trial aimed to compare functional outcomes, patient satisfaction, quality of life, and cost effectiveness following these treatments. Read More

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http://dx.doi.org/10.1016/j.jss.2019.01.011DOI Listing
February 2019

Role of policy in managing mined resources for construction in Europe and emerging economies.

J Environ Manage 2019 Feb 13;236:613-621. Epub 2019 Feb 13.

School of Natural and Environmental Sciences, Newcastle University, Newcastle upon Tyne, NE1 7RU, UK. Electronic address:

Rapid urbanisation, with associated housing and infrastructure demands, leads to increased mining and use of non-renewable mineral raw materials needed for the construction industry including concrete and cement. In an emerging economy, like Thailand, which is part of Association of Southeast Asian Nations (ASEAN), current environmental management policies are insufficient to reduce raw material requirements or waste from demolition by generating inputs to construction through reuse or recycling. As part of the European Union (EU), Great Britain has successfully implemented integrated policies and achieved high rates of recycled aggregates in construction (29%) and a 70% reuse and recycling target for construction and demolition (C&D) waste. Read More

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http://dx.doi.org/10.1016/j.jenvman.2018.11.141DOI Listing
February 2019

Socioeconomic differences in the associations between diabetes and hospital admission and mortality among older adults in Europe.

Econ Hum Biol 2019 Jan 17;33:89-100. Epub 2019 Jan 17.

Department of Economics and GEN, University of Cantabria. Avenue. Los Castros, s/n, Santander, CP 39005, Spain. Electronic address:

The aim of this study is to explain the trends in socioeconomic inequality and diabetes outcomes in terms of hospital admission and death in old European people. The sample includes 73,301 individuals, across 16 European countries taken from the Survey of Health, Ageing and Retirement in Europe (SHARE). People being diagnosed of diabetes were more likely to be admitted to hospital than those without diabetes, although its effect dropped after controlling for clinical and functional complications. Read More

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http://dx.doi.org/10.1016/j.ehb.2018.12.007DOI Listing
January 2019

Characterization, prognosis, and treatment of patients with metastatic lung carcinoid tumors.

J Thorac Oncol 2019 Feb 13. Epub 2019 Feb 13.

Service d'Oncologie Médicale, Groupement Hospitalier Centre, Institut de Cancérologie des Hospices Civils de Lyon, Lyon, France; University of Lyon, Université Lyon 1, France. Electronic address:

Introduction: Metastatic lung carcinoids (MLC) remain poorly characterized and no prognostic stratification exists.

Methods: We conducted a retrospective study including patients with MLC in two European expert centers. The aims were to characterize these, identify prognostic factors of survival, and effectiveness of their treatments. Read More

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http://dx.doi.org/10.1016/j.jtho.2019.02.002DOI Listing
February 2019

Toxicological assessment compilation of selected examples of raw materials for homeopathic medicinal products.

Regul Toxicol Pharmacol 2019 Feb 13. Epub 2019 Feb 13.

Federal Institute for Drugs and Medical Devices (Bundesinstitut für Arzneimittel und Medizinprodukte, BfArM), Kurt-Georg-Kiesinger-Allee 3, 53175, Bonn, Germany.

The considerable number of homeopathic medicinal products (HMP) on the German market and the staggering breadth of active substances of various origin along with the specific legal requirements of adequate safety principles posed the need to compile data on toxicologically evaluated raw materials. In line with the European regulatory framework, HMP applications must consider appropriate safety standards in analogy to conventional human medicinal products. This review presents an option for a systematic and scientifically substantiated approach for regulatory use. Read More

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http://dx.doi.org/10.1016/j.yrtph.2019.02.007DOI Listing
February 2019

Child, Mother, Father, and Teacher Beliefs About Child Academic Competence: Predicting Math and Reading Performance in European American Adolescents.

J Res Adolesc 2019 Feb 16. Epub 2019 Feb 16.

Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Public Health Service.

Beliefs about child competence in math and reading have important implications for academic performance in adolescence. However, it is unclear whether children's own beliefs are the most important predictor of their academic performance or whether parents' and teachers' beliefs about child competence influence child academic performance. We assessed mothers', fathers', teachers', and children's beliefs about European American children's (N = 189) competence in math and reading at age 10 and children's math and language performance at ages 10, 13, and 18 years. Read More

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http://dx.doi.org/10.1111/jora.12477DOI Listing
February 2019

Changes in self-concept and risk of psychotic experiences in adolescence: a longitudinal population based cohort study.

J Child Psychol Psychiatry 2019 Feb 16. Epub 2019 Feb 16.

Department of Psychiatry, Royal College of Surgeons in Ireland, Dublin 2, Ireland.

Background: Psychotic experiences (PEs) are commonly reported in adolescence and are associated with a range of negative outcomes. Few targets for intervention for PEs have been identified. One potential target is self-concept: an individual's beliefs about his/her personal attributes. Read More

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http://dx.doi.org/10.1111/jcpp.13022DOI Listing
February 2019

Balancing diversity and connectivity in multi-level governance settings for urban transformative capacity.

Authors:
Sara Borgström

Ambio 2019 Feb 15. Epub 2019 Feb 15.

Department of Sustainable Development, Environmental Science and Engineering, The Royal Institute of Technology, 100 44, Stockholm, Sweden.

Transformation towards sustainable development is about findings new ways of thinking, organising and doing to navigate wicked challenges such as climate change and urbanisation. Such challenges call for new governance modes that match the complexity of the systems to be handled, where multi-level governance and collaborative approaches have been suggested to contribute to such transformative capacity building. This in-depth, trans-disciplinary study investigates how the multi-level governance context in Stockholm, Sweden, influences the transformative capacity from the perspective of local sustainability initiatives. Read More

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http://dx.doi.org/10.1007/s13280-018-01142-1DOI Listing
February 2019

C. elegans as a Model for Synucleinopathies and Other Neurodegenerative Diseases: Tools and Techniques.

Methods Mol Biol 2019 ;1948:93-112

University of Groningen, University Medical Center Groningen, European Research Institute for the Biology of Aging, Groningen, The Netherlands.

Caenorhabditis elegans is widely used to investigate biological processes related to health and disease. Multiple C. elegans models for human neurodegenerative diseases do exist, including those expressing human α-synuclein. Read More

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http://dx.doi.org/10.1007/978-1-4939-9124-2_9DOI Listing
January 2019

Pattern of Cerebellar Atrophy in Friedreich's Ataxia-Using the SUIT Template.

Cerebellum 2019 Feb 15. Epub 2019 Feb 15.

Department of Neurology and Hertie Institute for Clinical Brain Research, Eberhard Karls University, Hoppe-Seyler-Str. 3, 72076, Tübingen, Germany.

Whole-brain voxel-based morphometry (VBM) studies revealed patterns of patchy atrophy within the cerebellum of Friedreich's ataxia patients, missing clear clinico-anatomic correlations. Studies so far are lacking an appropriate registration to the infratentorial space. To circumvent these limitations, we applied a high-resolution atlas template of the human cerebellum and brainstem (SUIT template) to characterize regional cerebellar atrophy in Friedreich's ataxia (FRDA) on 3-T MRI data. Read More

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http://dx.doi.org/10.1007/s12311-019-1008-zDOI Listing
February 2019

Just choice: a Danielsian analysis of the aims and scope of prenatal screening for fetal abnormalities.

Med Health Care Philos 2019 Feb 15. Epub 2019 Feb 15.

Department of Health, Ethics and Society, GROW School for Oncology and Developmental Biology, Faculty of Health, Medicine and Life Sciences, Maastricht University, 6200 MD, Maastricht, The Netherlands.

Developments in Non-Invasive Prenatal Testing (NIPT) and cell-free fetal DNA analysis raise the possibility that antenatal services may soon be able to support couples in non-invasively testing for, and diagnosing, an unprecedented range of genetic disorders and traits coded within their unborn child's genome. Inevitably, this has prompted debate within the bioethics literature about what screening options should be offered to couples for the purpose of reproductive choice. In relation to this problem, the European Society of Human Genetics (ESHG) and American Society of Human Genetics (ASHG) tentatively recommend that any expansion of this type of screening, as facilitated by NIPT, should be limited to serious congenital and childhood disorders. Read More

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http://dx.doi.org/10.1007/s11019-019-09888-5DOI Listing
February 2019

European association for endoscopic surgery (EAES) consensus statement on single-incision endoscopic surgery.

Surg Endosc 2019 Feb 15. Epub 2019 Feb 15.

Department of Surgery, Maastricht University Medical Center, Maastricht, The Netherlands.

Background: Laparoscopic surgery changed the management of numerous surgical conditions. It was associated with many advantages over open surgery, such as decreased postoperative pain, faster recovery, shorter hospital stay and excellent cosmesis. Since two decades single-incision endoscopic surgery (SIES) was introduced to the surgical community. Read More

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http://dx.doi.org/10.1007/s00464-019-06693-2DOI Listing
February 2019
3.256 Impact Factor

Ticks (Acari: Ixodida) on birds (Aves) migrating through the Polish Baltic coast.

Exp Appl Acarol 2019 Feb 15. Epub 2019 Feb 15.

Faculty of Biological Sciences, University of Zielona Góra, Prof. Z. Szafrana Str. 1, 65-516, Zielona Góra, Poland.

Seasonal bird (Aves) migration between breeding and wintering areas, often located on different continents, can facilitate the spreading of tick species (Acari: Ixodida) and of tick-borne pathogens. The aim of the study was to analyse the occurrence of ticks dispersed by birds migrating along the Polish Baltic coast during spring and autumn migration. Field research was conducted at the bird ringing station in Wicie, located on the middle of the Polish Baltic coast, in 2011 and 2012 during spring and autumn migration. Read More

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http://dx.doi.org/10.1007/s10493-019-00341-zDOI Listing
February 2019

[Comments on the guidelines (2018) of the European Society of Cardiology (ESC) and the European Society of Hypertension (ESH) on the management of arterial hypertension].

Internist (Berl) 2019 Feb 15. Epub 2019 Feb 15.

Institut für Klinische Pharmakologie und Toxikologie, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, und Berlin Institute of Health, Charitéplatz 1, Berlin, 10117, Deutschland.

Arterial hypertension represents one of the most frequent chronic diseases that can lead to complications, such as stroke, dementia, heart attack, heart failure and renal failure. By 2025 the number of hypertensive patients will increase to approximately 1.6 billion people worldwide. Read More

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http://dx.doi.org/10.1007/s00108-019-0576-9DOI Listing
February 2019

A computational study of Anthracyclines interacting with lipid bilayers: Correlation of membrane insertion rates, orientation effects and localisation with cytotoxicity.

Authors:
D Toroz I R Gould

Sci Rep 2019 Feb 15;9(1):2155. Epub 2019 Feb 15.

Department of Chemistry, Imperial College London, London, SW7 2AZ, UK.

Anthracyclines interact with DNA and topoisomerase II as well as with cell membranes, and it is these latter interactions that can cause an increase in their cytotoxic activity. In the present study a detailed computational analysis of the initial insertion, orientation and nature of the interaction occurring between Anthracyclines and two different lipid bilayers (unsaturated POPC and saturated DMPC) is explored through molecular dynamics (MD) simulations; four Anthracyclines: Doxorubicin (DOX), Epirubicin (EPI), Idarubicin (IDA) and Daunorubicin (DAU) were examined. The results indicate that the increased cytotoxicity of DOX, in comparison to the other three analogues, is correlated with its ability to diffuse at a faster rate into the bilayers. Read More

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http://dx.doi.org/10.1038/s41598-019-39411-yDOI Listing
February 2019

Reverse immunodynamics: a new method for identifying targets of protective immunity.

Sci Rep 2019 Feb 15;9(1):2164. Epub 2019 Feb 15.

Department of Zoology, University of Oxford, Oxford, OX1 3PS, UK.

Despite a dramatic increase in our ability to catalogue variation among pathogen genomes, we have made far fewer advances in using this information to identify targets of protective immunity. Epidemiological models predict that strong immune selection can cause antigenic variants to structure into genetically discordant sets of antigenic types (e.g. Read More

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http://dx.doi.org/10.1038/s41598-018-37288-xDOI Listing
February 2019

Multi-cohort study identifies social determinants of systemic inflammation over the life course.

Nat Commun 2019 Feb 15;10(1):773. Epub 2019 Feb 15.

LEASP, UMR 1027, Inserm-Université Toulouse III Paul Sabatier, Toulouse, 31000, France.

Chronic inflammation has been proposed as having a prominent role in the construction of social inequalities in health. Disentangling the effects of early life and adulthood social disadvantage on inflammation is key in elucidating biological mechanisms underlying socioeconomic disparities. Here we explore the relationship between socioeconomic position (SEP) across the life course and inflammation (as measured by CRP levels) in up to 23,008 participants from six European cohort studies from three countries conducted between 1958 and 2013. Read More

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http://dx.doi.org/10.1038/s41467-019-08732-xDOI Listing
February 2019

Divalent EuRhSi as a reference for the Luttinger theorem and antiferromagnetism in trivalent heavy-fermion YbRhSi.

Nat Commun 2019 Feb 15;10(1):796. Epub 2019 Feb 15.

Donostia International Physics Center (DIPC), 20080, San Sebastian, Spain.

Application of the Luttinger theorem to the Kondo lattice YbRhSi suggests that its large 4f-derived Fermi surface (FS) in the paramagnetic (PM) regime should be similar in shape and volume to that of the divalent local-moment antiferromagnet (AFM) EuRhSi in its PM regime. Here we show by angle-resolved photoemission spectroscopy that paramagnetic EuRhSi has a large FS essentially similar to the one seen in YbRhSi down to 1 K. In EuRhSi the onset of AFM order below 24. Read More

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http://dx.doi.org/10.1038/s41467-019-08688-yDOI Listing
February 2019

Mass spectrometry-based analysis of cerebrospinal fluid from arthritis patients-immune-related candidate proteins affected by TNF blocking treatment.

Arthritis Res Ther 2019 Feb 15;21(1):60. Epub 2019 Feb 15.

Rheumatology Unit, Department of Medicine, Solna, Center of Molecular Medicine (CMM), Karolinska Institutet, Karolinska University Hospital, SE-17176, Stockholm, Sweden.

Background: Signs of inflammation in cerebrospinal fluid (CSF) of rheumatoid arthritis patients correlate positively with fatigue, a central nervous system (CNS)-related symptom that can be partially suppressed by TNF blockade. This suggests a possible role for CNS inflammation in arthritis that may be affected by TNF blockade. We therefore investigated the effects of TNF blockade on the arthritis CSF proteome and how candidate proteins related to clinical measures of disease activity and inflammation. Read More

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http://dx.doi.org/10.1186/s13075-019-1846-6DOI Listing
February 2019