302,533 results match your criteria European journal of obstetrics gynecology and reproductive biology[Journal]


Raman characterization of single-crystalline Ga0.96Mn0.04As:Zn nanowires realized by ion-implantation.

Nanotechnology 2019 Apr 24. Epub 2019 Apr 24.

Universidade Federal do Pará, Belem, 66075-110, BRAZIL.

Recent progress in the realization of magnetic GaAs nanowires doped with Mn has attracted a lot of attention due to their potential application in spintronics. In this work, we present a detailed Raman investigation of the structural properties of Zn doped GaAs (GaAs:Zn) and Mn-implanted GaAs:Zn (Ga0.96Mn0. Read More

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http://dx.doi.org/10.1088/1361-6528/ab1beaDOI Listing

Evolution of alcohol and tobacco consumption in young people in Spain, after the law 42/2010 against smoking: 2011-2014.

Adicciones 2019 Mar 28;0(0):1035. Epub 2019 Mar 28.

Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC). Universidad de Córdoba. Hospital Universitario Reina Sofía de Córdoba. Universidad Pontificia de Salamanca.

The objective of the study was to evaluate alcohol and tobacco consumption in young people in Spain, after Law 42/2010, during the interval of 2011-2014. The sample consisted of 3270 young people aged between 15 and 24 years who completed the National Survey of Health in Spain (ENSE) of 2011 and the European Survey of Health in Spain (EESE) of 2014. Variables: consumption, type of tobacco, attempts to quit smoking, consumption and type of alcoholic beverage, binge drinking, and sociodemographic variables. Read More

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http://dx.doi.org/10.20882/adicciones.1035DOI Listing

Are we restoring functional fens? - The outcomes of restoration projects in fens re-analysed with plant functional traits.

PLoS One 2019 24;14(4):e0215645. Epub 2019 Apr 24.

Department of Plant Ecology & Environmental Conservation, Institute of Botany, Biological and Chemical Research Centre, University of Warsaw, Warsaw, Poland.

In peatland restoration we often lack an information whether re-established ecosystems are functionally similar to non-degraded ones. We re-analysed the long-term outcomes of restoration on vegetation and plant functional traits in 38 European fens restored by rewetting (18 sites) and topsoil removal (20 sites). We used traits related to nutrient acquisition strategies, competitiveness, seed traits, and used single- and multi-trait metrics. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215645PLOS

Mapping Europe into local climate zones.

PLoS One 2019 24;14(4):e0214474. Epub 2019 Apr 24.

School of Geography, University College Dublin, Dublin, Ireland.

Cities are major drivers of environmental change at all scales and are especially at risk from the ensuing effects, which include poor air quality, flooding and heat waves. Typically, these issues are studied on a city-by-city basis owing to the spatial complexity of built landscapes, local topography and emission patterns. However, to ensure knowledge sharing and to integrate local-scale processes with regional and global scale modelling initiatives, there is a pressing need for a world-wide database on cities that is suited for environmental studies. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214474PLOS

Comprehensive Study of the Proteome and Transcriptome of the Venom of the Most Venomous European Viper: Discovery of a New Subclass of Ancestral Snake Venom Metalloproteinase Precursor-Derived Proteins.

J Proteome Res 2019 Apr 24. Epub 2019 Apr 24.

Department of Molecular and Biomedical Sciences , Jožef Stefan Institute , Jamova cesta 39 , SI-1000 Ljubljana , Slovenia.

The nose-horned viper, its nominotypical subspecies Vipera ammodytes ammodytes ( Vaa), in particular, is, medically, one of the most relevant snakes in Europe. The local and systemic clinical manifestations of poisoning by the venom of this snake are the result of the pathophysiological effects inflicted by enzymatic and nonenzymatic venom components acting, most prominently, on the blood, cardiovascular, and nerve systems. This venom is a very complex mixture of pharmacologically active proteins and peptides. Read More

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http://dx.doi.org/10.1021/acs.jproteome.9b00120DOI Listing

Estimation of the Required Lipoprotein(a)-Lowering Therapeutic Effect Size for Reduction in Coronary Heart Disease Outcomes: A Mendelian Randomization Analysis.

JAMA Cardiol 2019 Apr 24. Epub 2019 Apr 24.

Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Medical University of Innsbruck, Innsbruck, Austria.

Importance: Genetic and epidemiologic data suggest that lipoprotein(a) (Lp[a]) is one of the strongest genetically determined risk factors for coronary heart disease (CHD). Specific therapies to lower Lp(a) are on the horizon, but the required reduction of Lp(a) to translate into clinically relevant lowering of CHD outcomes is a matter of debate.

Objective: To estimate the required Lp(a)-lowering effect size that may be associated with a reduction of CHD outcomes compared with the effect size of low-density lipoprotein cholesterol (LDL-C)-lowering therapies. Read More

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http://dx.doi.org/10.1001/jamacardio.2019.1041DOI Listing

Analytical validation of a standardized scoring protocol for Ki67 immunohistochemistry on breast cancer excision whole sections: an international multicenter collaboration.

Histopathology 2019 Apr 24. Epub 2019 Apr 24.

The Institute of Cancer Research, London, United Kingdom.

Aims: The nuclear proliferation marker Ki67 assayed by immunohistochemistry has multiple potential uses in breast cancer, but an unacceptable level of inter-laboratory variability has hampered its clinical utility. The International Ki67 in Breast Cancer Working Group has undertaken a systematic program to determine whether Ki67 measurement can be analytically validated and standardized across laboratories. This study addresses whether acceptable scoring reproducibility can be achieved on excision whole sections. Read More

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http://dx.doi.org/10.1111/his.13880DOI Listing

Cytotoxic and proinflammatory responses induced by ZnO nanoparticles in in vitro intestinal barrier.

J Appl Toxicol 2019 Apr 24. Epub 2019 Apr 24.

Department of Veterinary Medicine (DIMEVET), Università degli Studi di Milano, via Celoria 10, I-20133, Milan, Italy.

ZnO nanoparticles (NPs) are widely used nowadays, thus the gastrointestinal exposure to ZnO NPs is likely to be relevant and the effects on the intestinal barrier should be investigated. Polarized Caco-2 cells were exposed from the apical (Ap) and basolateral (Bl) compartments to increasing concentrations (0, 10, 50 and 100 μg/mL) of sonochemical (sono) and commercial ZnO NPs. The transepithelial electrical resistance (TEER), cell viability, proinflammatory cytokine release and presence of protein oxidative damage were evaluated after exposure. Read More

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http://dx.doi.org/10.1002/jat.3800DOI Listing

Tissue resident T cell memory or how the magnificent seven are chilling in the bone.

Eur J Immunol 2019 Apr 24. Epub 2019 Apr 24.

Viral Immunobiology, Institute of Experimental Immunology, University of Zürich, Switzerland.

Following infection, tissue resident memory T cells (Trm) are thought to be left behind at sites of antigen encounter to protect affected tissues against subsequent reinfection. In this issue of the European Journal of Immunology, however, Pascutti et al. [Eur. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/eji.20194820
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http://dx.doi.org/10.1002/eji.201948208DOI Listing
April 2019
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Surgical Metastasectomy in Renal Cell Carcinoma: A Systematic Review.

Eur Urol Oncol 2019 Mar 24;2(2):141-149. Epub 2018 Sep 24.

Department of Urology, University of Rennes, Rennes, France.

Context: The benefit of surgical metastasectomy (SM) for patients with metastatic renal cell carcinoma (mRCC) remains controversial because of the lack of high-level evidence on the role of SM in terms of survival benefit in the era of systemic therapy.

Objective: To perform a systematic review of the literature on the role of SM in the treatment of mRCC and discuss key issues in the SM decision-making process.

Evidence Acquisition: A systematic search of the Embase and Medline databases was carried out and a systematic review of the role of SM in mRCC was performed. Read More

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http://dx.doi.org/10.1016/j.euo.2018.08.028DOI Listing

Author's correction for Euro Surveill. 2019;24(14).

Euro Surveill 2019 Apr;24(15)

European Centre for Disease Prevention and Control (ECDC), Stockholm, Sweden.

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http://dx.doi.org/10.2807/1560-7917.ES.2018.24.15.190411eDOI Listing
April 2019
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Prevalence of asthma and respiratory symptoms during pregnancy in the middle belt of Nigeria.

J Asthma 2019 Apr 24:1-10. Epub 2019 Apr 24.

a Department of Medicine , University of Ilorin Teaching Hospital , Ilorin , Nigeria.

Background: Information about the burden of asthma during pregnancy in Africa is scarce.

Objectives: To determine the prevalence of asthma and respiratory symptoms in pregnancy in Ilorin, Nigeria.

Methods: This study uses the European Community Respiratory Health Survey (ECRHS) questionnaire and definitions to screen 870 pregnant women attending three hospitals for asthma. Read More

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http://dx.doi.org/10.1080/02770903.2019.1606236DOI Listing

[Advances in etiology, epidemiology and genetic diversity of ].

Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 2019 Mar;31(1):86-93

Department of Parasitology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450052, China.

and are three causative agents of human thelaziasis. Most of the reported cases were caused by , occurring in the old world, particularly in Asian and European countries. and have rarely been reported infecting humans in North America. Read More

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http://www.cnki.net/kcms/doi/10.16250/j.32.1374.2018300.html
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http://dx.doi.org/10.16250/j.32.1374.2018300DOI Listing
March 2019
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Effectiveness of a multimodal intervention in functionally impaired older people with type 2 diabetes mellitus.

J Cachexia Sarcopenia Muscle 2019 Apr 23. Epub 2019 Apr 23.

Foundation for Diabetes Research in Older People, Diabetes Frail Ltd, Luton, UK.

Background: Type 2 diabetes, a highly prevalent chronic disease, is associated with increasing frailty and functional decline in older people. We aimed to evaluate the effectiveness of a multimodal intervention on functional performance in frail and pre-frail participants aged ≥70 years with type 2 diabetes mellitus.

Methods: The MID-Frail study was a cluster-randomized multicenter clinical trial conducted in 74 trial sites across seven European countries. Read More

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http://dx.doi.org/10.1002/jcsm.12432DOI Listing

Agar plate-based screening methods for the identification of polyester hydrolysis by Pseudomonas species.

Microb Biotechnol 2019 Apr 23. Epub 2019 Apr 23.

Institute of Molecular Enzyme Technology, Heinrich-Heine-University Düsseldorf, Forschungszentrum Jülich, D-52425, Jülich, Germany.

Hydrolases acting on polyesters like cutin, polycaprolactone or polyethylene terephthalate (PET) are of interest for several biotechnological applications like waste treatment, biocatalysis and sustainable polymer modifications. Recent studies suggest that a large variety of such enzymes are still to be identified and explored in a variety of microorganisms, including bacteria of the genus Pseudomonas. For activity-based screening, methods have been established using agar plates which contain nanoparticles of polycaprolactone or PET prepared by solvent precipitation and evaporation. Read More

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http://dx.doi.org/10.1111/1751-7915.13418DOI Listing

The Urological Association of Asia clinical guideline for urinary stone disease.

Int J Urol 2019 Apr 24. Epub 2019 Apr 24.

Department of Nephro-urology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.

The Urological Association of Asia, consisting of 25 member associations and one affiliated member since its foundation in 1990, has planned to develop Asian guidelines for all urological fields. The field of stone diseases is the third of its guideline projects. Because of the different climates, and social, economic and ethnic environments, the clinical practice for urinary stone diseases widely varies among the Asian countries. Read More

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http://dx.doi.org/10.1111/iju.13957DOI Listing

Measuring the impact of European colonization on Native American populations in Southern Brazil and Uruguay: Evidence from mtDNA.

Am J Hum Biol 2019 Apr 23:e23243. Epub 2019 Apr 23.

Programa de Pós-Graduação em Biologia Animal, Instituto de Biociências, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.

Objectives: The major aim of this article was to estimate the demographic impact of European arrival and colonization over Native American populations from southern Brazil and Uruguay. We also compared the mitochondrial DNA (mtDNA) genetic diversity, structure, and demography of Native American lineages present in current indigenous (Natives) and nonindigenous admixed (Admixed) populations to estimate the effective population size (N ) of contemporary and ancestral (pre-Columbian) Native American populations.

Methods: We retrieved published mtDNA sequences from Native (n = 396) and Admixed (n = 309) populations from southern Brazil, Uruguay, and surrounding areas. Read More

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http://dx.doi.org/10.1002/ajhb.23243DOI Listing

Significant changes in hepatic transcriptome and circulating miRNAs are associated with diet-induced metabolic syndrome in apoE3L.CETP mice.

J Cell Physiol 2019 Apr 23. Epub 2019 Apr 23.

Laboratory of Biochemistry, Division of Basic Sciences, University of Crete Medical School, Heraklion, Greece.

Long-term exposure to excess dietary fat leads to obesity and the metabolic syndrome (MetS). The purpose of the present study was to identify global changes in liver gene expression and circulating miRNAs in a humanized mouse model of diet-induced MetS. Male apoE3L. Read More

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http://dx.doi.org/10.1002/jcp.28649DOI Listing

How to reject Benatar's asymmetry argument.

Authors:
Erik Magnusson

Bioethics 2019 Apr 23. Epub 2019 Apr 23.

Centre for Professional & Applied Ethics, University of Manitoba, Winnipeg, Canada.

In this article I reconsider David Benatar's primary argument for anti-natalism-the asymmetry argument-and outline a three-step process for rejecting it. I begin in Part 2 by reconstructing the asymmetry argument into three main premises. I then turn in Parts 3-5 to explain how each of these premises is in fact false. Read More

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http://dx.doi.org/10.1111/bioe.12582DOI Listing

The Story of Helicobacter pylori: Depicting Human Migrations from the Phylogeography.

Adv Exp Med Biol 2019 Apr 24. Epub 2019 Apr 24.

Department of Environmental and Preventive Medicine, Faculty of Medicine, Oita University, Yufu, Japan.

Helicobacter pylori is a spiral-shaped Gram-negative bacterium, which has infected more than half of the human population. Besides its colonisation capability, the genetic diversity of H. pylori is exceptionally well structured and belongs to several distinct genetic populations, depicting various prehistorical human migration events. Read More

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http://link.springer.com/10.1007/5584_2019_356
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http://dx.doi.org/10.1007/5584_2019_356DOI Listing
April 2019
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Pica behaviors in a German community-based online adolescent and adult sample: an examination of substances, triggers, and associated pathology.

Eat Weight Disord 2019 Apr 23. Epub 2019 Apr 23.

Clinical Psychology and Psychotherapy, Institute of Psychology, Department of Human Sciences, Osnabrück University, Knollstr. 15, 49069, Osnabrück, Germany.

Purpose: To examine self-reported pica substances, situational triggers for, and associated psychosocial burden of pica eating in adolescents and adults in a Western European population.

Methods: A total of 78 individuals aged 16 years and over, who indicated consuming a substance that in their opinion is not considered as food, participated in an online survey. Two questionnaires assessed eating disorder and general psychopathology, and a third asked about the substances consumed, duration and frequency of consumption, triggers for consumption, emotions thereafter, and interest in treatment. Read More

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http://dx.doi.org/10.1007/s40519-019-00693-wDOI Listing

Sarcoma Stem Cell Heterogeneity.

Adv Exp Med Biol 2019 ;1123:95-118

Central University Hospital of Asturias-Health Research Institute of Asturias, Oviedo, Spain.

Sarcomas represent an extensive group of divergent malignant diseases, with the only common characteristic of being derived from mesenchymal cells. As such, sarcomas are by definition very heterogeneous, and this heterogeneity does not manifest only upon intertumoral comparison on a bulk tumor level but can be extended to intratumoral level. Whereas part of this intratumoral heterogeneity could be understood in terms of clonal genetic evolution, an essential part includes a hierarchical relationship between sarcoma cells, governed by both genetic and epigenetic influences, signals that sarcoma cells are exposed to, and intrinsic developmental programs derived from sarcoma cells of origin. Read More

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http://dx.doi.org/10.1007/978-3-030-11096-3_7DOI Listing
January 2019

Clinical characteristics of Polish patients with ANCA-associated vasculitides-retrospective analysis of POLVAS registry.

Clin Rheumatol 2019 Apr 23. Epub 2019 Apr 23.

2nd Department of Internal Medicine, Faculty of Medicine, Jagiellonian University Medical College, ul. Skawińska 8, 31-066, Kraków, Poland.

Objective: Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) are rare small to medium-size vessel systemic diseases. As their clinical picture, organ involvement, and factors influencing outcome may differ between countries and geographical areas, we decided to describe a large cohort of Polish AAV patients coming from several referral centers-members of the Scientific Consortium of the Polish Vasculitis Registry (POLVAS).

Methods: We conducted a systematic multicenter retrospective study of adult patients diagnosed with AAV between Jan 1990 and Dec 2016 to analyze their clinical picture, organ involvement, and factors influencing outcome. Read More

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http://dx.doi.org/10.1007/s10067-019-04538-wDOI Listing

Circadian Rhythms and Locomotor Activity of Smolts of the European River Lamprey Lampetra fluviatilis (L.).

Dokl Biol Sci 2019 May 23;484(1):16-18. Epub 2019 Apr 23.

Severtsov Institute of Ecology and Evolution, Russian Academy of Sciences, 119071, Moscow, Russia.

Locomotor activity was investigated in smolts of the European river lamprey at alternation of light and darkness (12/12 h) and in the dark. Two groups of smolts were discerned differing in the level of locomotor activity. The presence of the circadian rhythm in smolts has been revealed, and its role in downstream migration has been shown. Read More

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http://dx.doi.org/10.1134/S0012496619010034DOI Listing

Para-aortic Lymphadenectomy for Gynecologic Cancers: Introducing the "Trans-Retro-Peritoneal (TRP) Single-Port Access".

Ann Surg Oncol 2019 Apr 23. Epub 2019 Apr 23.

Department of Gynaecology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.

Background: In gynecological surgery to date, two distinct types of endoscopic accesses have been used to perform para-aortic lymphadenectomies: transperitoneal and extraperitoneal, each with advantages and disadvantages. We propose to develop a new mini-invasive access to perform an endoscopic extraperitoneal para-aortic lymphadenectomy via a single-port umbilical device that, to our knowledge, has never been described.

Methods: This innovative approach combines both an extraperitoneal and intraperitoneal procedure via the same umbilical incision using one single trocar. Read More

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http://dx.doi.org/10.1245/s10434-019-07379-8DOI Listing

Suggestions to Improve the Comprehensibility of Current Definitions of Scientific Authorship for International Authors.

Sci Eng Ethics 2019 Apr 23. Epub 2019 Apr 23.

Department of Philosophy and Religious Studies - Ethiek Instituut, Utrecht University, Janskerkhof 13, 3512 BL, Utrecht, The Netherlands.

Much has been said about the need for improving the current definitions of scientific authorship, but an aspect that is often overlooked is how to formulate and communicate these definitions to ensure that they are comprehensible and useful for researchers, notably researchers active in international research consortia. In light of a rapid increase in international collaborations within natural sciences, this article uses authorship of this branch of sciences as an example and provides suggestions to improve the comprehensibility of the definitions of authorship in natural sciences. It assesses whether the definition of authorship provided by the European Code of Conduct for Research Integrity can deal with current issues and problems of scientific authorship. Read More

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http://dx.doi.org/10.1007/s11948-019-00106-2DOI Listing

Reduced ambient temperature exacerbates SIRS-induced cardiac autonomic dysregulation and myocardial dysfunction in mice.

Basic Res Cardiol 2019 Apr 23;114(3):26. Epub 2019 Apr 23.

Institute of Molecular Cell Biology, Jena University Hospital, Friedrich Schiller University, Hans-Knöll-Straße 2, 07745, Jena, Germany.

Sepsis-induced myocardial depression (SIMD) is an early and frequent consequence of the infection-induced systemic inflammatory response syndrome. In homiotherms, variations in ambient temperature (T) outside the thermoneutral zone induce thermoregulatory responses mainly driven by a gradually increased sympathetic activity, which may affect disease severity. We hypothesized that thermoregulatory responses upon reduced T exposition aggravate SIMD in mice. Read More

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http://dx.doi.org/10.1007/s00395-019-0734-1DOI Listing

Novel Non-biologic Targets for Inflammatory Bowel Disease.

Curr Gastroenterol Rep 2019 Apr 23;21(5):22. Epub 2019 Apr 23.

Dr. Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1069, New York, NY, 10029, USA.

Purpose Of Review: The biologic era revolutionized the medical management of inflammatory bowel disease (IBD) and allowed for a paradigm shift away from a therapeutic strategy that traditionally relied on corticosteroids and immunomodulators. IBD treatment has now further evolved to encompass novel non-biologic agents.

Recent Findings: An electronic database search, spanning up to September 2018, was conducted using PubMed, Web of Science, Google Scholar, and Scopus. Read More

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http://link.springer.com/10.1007/s11894-019-0689-2
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http://dx.doi.org/10.1007/s11894-019-0689-2DOI Listing
April 2019
3 Reads

Priorities for protecting health from climate change in the WHO European Region: recent regional activities.

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 2019 Apr 18. Epub 2019 Apr 18.

World Health Organization Regional Office for Europe, European Centre for Environment and Health, Platz der Vereinigten Nationen 1, 53113, Bonn, Germany.

Evidence of the impact of climate change on health is growing. Health systems need to be prepared and gradually adapt to the effects of climate change, including extreme weather events.Fossil fuel combustion as the driver of climate change poses a tremendous burden of disease. Read More

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http://dx.doi.org/10.1007/s00103-019-02943-9DOI Listing

Bidirectional sliding of two parallel microtubules generated by multiple identical motors.

J Math Biol 2019 Apr 23. Epub 2019 Apr 23.

School of Mathematics and Physics, The University of Queensland, St. Lucia, QLD, 4072, Australia.

It is often assumed in biophysical studies that when multiple identical molecular motors interact with two parallel microtubules, the microtubules will be crosslinked and locked together. The aim of this study is to examine this assumption mathematically. We model the forces and movements generated by motors with a time-continuous Markov process and find that, counter-intuitively, a tug-of-war results from opposing actions of identical motors bound to different microtubules. Read More

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http://dx.doi.org/10.1007/s00285-019-01369-wDOI Listing

Meniscus Subluxation Retensioning: "Autotransplant".

Arthrosc Tech 2019 Mar 25;8(3):e335-e341. Epub 2019 Feb 25.

Clínica do Dragão, Espregueira-Mendes Sports Centre-FIFA Medical Centre of Excellence, Porto, Portugal.

Knee osteoarthritis (OA) is a common condition in the older population and is characterized by several articular dysfunctions with consequent anatomic abnormalities including osteochondral degenerative changes and meniscal extrusion. Meniscal damage with extrusion is one of the strongest identified risk factors for the development and progression of knee OA and represents an important factor in the long-term health of the joint. Meniscal extrusion can alter normal knee biomechanics and dramatically inhibit meniscal function. Read More

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http://dx.doi.org/10.1016/j.eats.2018.11.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6475648PMC

Is the incidence of survival in interior Pleistocene refugia (nunataks) underestimated? Phylogeography of the high mountain plant (Primulaceae) in the European Alps revisited.

Ecol Evol 2019 Apr 7;9(7):4078-4086. Epub 2019 Mar 7.

Department of Botany and Biodiversity Research University of Vienna Vienna Austria.

Temperate mountain ranges such as the European Alps have been strongly affected by the Pleistocene glaciations. Glacial advances forced biota into refugia, which were situated either at the periphery of mountain ranges or in their interior. Whereas in the Alps peripheral refugia have been repeatedly and congruently identified, support for the latter scenario, termed "nunatak hypothesis," is still limited and no general pattern is recognizable yet. Read More

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http://dx.doi.org/10.1002/ece3.5037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468090PMC

The complex pathophysiology of allergic rhinitis: scientific rationale for the development of an alternative treatment option.

Allergy Asthma Clin Immunol 2019 16;15:24. Epub 2019 Apr 16.

5Department of Environmental Medicine, Karolinska Institutet, 171 77 Stockholm, Sweden.

Allergic rhinitis (AR) poses a global health problem and can be challenging to treat. Many of the current symptomatic treatments for AR have been available for decades, yet there has been little improvement in patient quality of life or symptom burden over the years. In this review, we ask why this might be and explore the pathophysiological gaps that exist within the various AR treatment classes. Read More

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http://dx.doi.org/10.1186/s13223-018-0314-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469109PMC

SOPH syndrome in three affected individuals showing similarities with progeroid cutis laxa conditions in early infancy.

J Hum Genet 2019 Apr 24. Epub 2019 Apr 24.

Institut für Medizinische Genetik und Humangenetik, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

Individuals affected with autosomal recessive cutis laxa type 2B and 3 usually show translucent skin with visible veins and abnormal elastic fibers, intrauterine and/or postnatal growth restriction and a typical triangular facial gestalt. Here we describe three unrelated individuals in whom such a cutis laxa syndrome was suspected, especially after electron microscopy revealed immature and less dense dermal elastic fibers in one of them. However, one of these children also displayed optic atrophy and two hypogammaglobulinemia. Read More

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http://www.nature.com/articles/s10038-019-0602-8
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http://dx.doi.org/10.1038/s10038-019-0602-8DOI Listing
April 2019
1 Read

Iron deficiency disrupts embryonic haematopoiesis but not the endothelial to haematopoietic transition.

Sci Rep 2019 Apr 23;9(1):6414. Epub 2019 Apr 23.

European Molecular Biology Laboratory, EMBL Rome, Epigenetics and Neurobiology Unit, Via Ramarini 32, 00015, Monterotondo, Italy.

In this study, we aimed to explore how cellular iron status affects embryonic haematopoiesis. For this purpose, we used a model of mouse embryonic stem cell differentiation into embryonic haematopoietic progenitors. We modulated the iron status by adding either the iron chelator Deferoxamine (DFO) for iron deficiency, or ferric ammonium citrate for iron excess, and followed the emergence of developing haematopoietic progenitors. Read More

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http://dx.doi.org/10.1038/s41598-019-42765-yDOI Listing

Particle velocity controls phase transitions in contagion dynamics.

Sci Rep 2019 Apr 23;9(1):6463. Epub 2019 Apr 23.

Instituto de Física Interdisciplinar y Sistemas Complejos IFISC (CSIC-UIB), Palma de Mallorca, E-07122, Spain.

Interactions often require the proximity between particles. The movement of particles, thus, drives the change of the neighbors which are located in their proximity, leading to a sequence of interactions. In pathogenic contagion, infections occur through proximal interactions, but at the same time, the movement facilitates the co-location of different strains. Read More

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http://dx.doi.org/10.1038/s41598-019-42871-xDOI Listing

The extracellular matrix protects Bacillus subtilis colonies from Pseudomonas invasion and modulates plant co-colonization.

Nat Commun 2019 Apr 23;10(1):1919. Epub 2019 Apr 23.

Instituto de Hortofruticultura Subtropical y Mediterránea "La Mayora", Universidad de Málaga-Consejo Superior de Investigaciones Científicas (IHSM-UMA-CSIC), Departamento de Microbiología, Universidad de Málaga, Bulevar Louis Pasteur 31 (Campus Universitario de Teatinos), 29071, Málaga, Spain.

Bacteria of the genera Pseudomonas and Bacillus can promote plant growth and protect plants from pathogens. However, the interactions between these plant-beneficial bacteria are understudied. Here, we explore the interaction between Bacillus subtilis 3610 and Pseudomonas chlororaphis PCL1606. Read More

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http://dx.doi.org/10.1038/s41467-019-09944-xDOI Listing

The future of Southeast Asia's forests.

Nat Commun 2019 Apr 23;10(1):1829. Epub 2019 Apr 23.

University of Tsukuba, Tsukuba, Japan.

While Southeast Asia's forests play important roles in biodiversity conservation and global carbon (C) balance, the region is also a deforestation hotspot. Here, we consider the five shared socioeconomic pathways (SSPs) to portray a range of plausible futures for the region's forests, employing a state-of-the-art land change modelling procedure and remotely sensed data. We find that by 2050 under the worst-case scenario, SSP 3 (regional rivalry/a rocky road), the region's forests would shrink by 5. Read More

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http://dx.doi.org/10.1038/s41467-019-09646-4DOI Listing

Lamin B1 loss promotes lung cancer development and metastasis by epigenetic derepression of RET.

J Exp Med 2019 Apr 23. Epub 2019 Apr 23.

Max Planck Institute for Heart and Lung Research, Member of the German Center for Lung Research, Bad Nauheim, Germany

Although abnormal nuclear structure is an important criterion for cancer diagnostics, remarkably little is known about its relationship to tumor development. Here we report that loss of lamin B1, a determinant of nuclear architecture, plays a key role in lung cancer. We found that lamin B1 levels were reduced in lung cancer patients. Read More

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http://dx.doi.org/10.1084/jem.20181394DOI Listing

Desmopressin treatment combined with clotting factor VIII concentrates in patients with non-severe haemophilia A: protocol for a multicentre single-armed trial, the DAVID study.

BMJ Open 2019 Apr 23;9(4):e022719. Epub 2019 Apr 23.

Department of Haematology, Erasmus University Medical Centre, Rotterdam, The Netherlands.

Introduction: Haemophilia A is an inherited bleeding disorder characterised by factor VIII (FVIII) deficiency. In patients with non-severe haemophilia A, surgery and bleeding are the main indications for treatment with FVIII concentrate. A recent study reported that standard dosing frequently results in FVIII levels (FVIII:C) below or above FVIII target ranges, leading to respectively a bleeding risk or excessive costs. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-022719DOI Listing

Statins for primary prevention of cardiovascular disease: modelling guidelines and patient preferences based on an Irish cohort.

Br J Gen Pract 2019 Apr 23. Epub 2019 Apr 23.

Department of General Practice, Royal College of Surgeons in Ireland, and Health Research Board Centre for Primary Care Research, Dublin, Ireland.

Background: Changes in clinical guidelines for primary prevention of cardiovascular disease (CVD) have widened eligibility for statin therapy.

Aim: To illustrate the potential impacts of changes in clinical guidelines.

Design And Setting: Modelling the impacts of seven consecutive European guidelines based on a cohort of people aged ≥50 years from the Irish Longitudinal Study on Ageing. Read More

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http://dx.doi.org/10.3399/bjgp19X702701DOI Listing

A parsimonious 3-gene signature predicts clinical outcomes in an acute myeloid leukemia multicohort study.

Blood Adv 2019 Apr;3(8):1330-1346

John van Geest Cancer Research Centre, College of Science and Technology, Nottingham Trent University, Nottingham, United Kingdom.

Acute myeloid leukemia (AML) is a genetically heterogeneous hematological malignancy with variable responses to chemotherapy. Although recurring cytogenetic abnormalities and gene mutations are important predictors of outcome, 50% to 70% of AMLs harbor normal or risk-indeterminate karyotypes. Therefore, identifying more effective biomarkers predictive of treatment success and failure is essential for informing tailored therapeutic decisions. Read More

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http://dx.doi.org/10.1182/bloodadvances.2018030726DOI Listing
April 2019
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Analysis of heritability and genetic architecture of Pancreatic Cancer: A PanC4 Study.

Cancer Epidemiol Biomarkers Prev 2019 Apr 23. Epub 2019 Apr 23.

Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine

Background: Pancreatic cancer is the fourth-leading cause of cancer death in both men and women in the United States. Identified common susceptibility loci account for a small fraction of estimated heritability. We sought to estimate overall heritability of pancreatic cancer and partition the heritability by variant frequencies and functional annotations. Read More

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http://dx.doi.org/10.1158/1055-9965.EPI-18-1235DOI Listing

Consolidative thoracic radiotherapy in stage IV small cell lung cancer: Selection of patients amongst European IASLC and ESTRO experts.

Radiother Oncol 2019 Mar 15;135:74-77. Epub 2019 Mar 15.

Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands.

Background: The role of consolidative thoracic radiotherapy (TRT) in stage IV small cell lung cancer (SCLC) is not uniformly accepted.

Methods: We obtained a list of 13 European medical oncologists from the International Association for the Study of Lung Cancer (IASLC) and 13 European radiation oncologists from the European Society for Therapeutic Radiation Oncology (ESTRO). The strategies in decision making for TRT in stage IV SCLC were collected. Read More

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http://dx.doi.org/10.1016/j.radonc.2019.02.010DOI Listing

GEC-ESTRO ACROP recommendations on calibration and traceability of LE-LDR photon-emitting brachytherapy sources at the hospital level.

Radiother Oncol 2019 Mar 20;135:120-129. Epub 2019 Mar 20.

UK S-H, Campus Kiel, Klinik für Strahlentherapie (Radioonkologie), Kiel, Germany.

Prostate brachytherapy treatment using permanent implantation of low-energy (LE) low-dose rate (LDR) sources is successfully and widely applied in Europe. In addition, seeds are used in other tumour sites, such as ophthalmic tumours, implanted temporarily. The calibration issues for LE-LDR photon emitting sources are specific and different from other sources used in brachytherapy. Read More

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http://dx.doi.org/10.1016/j.radonc.2019.02.008DOI Listing

A high-throughput screen for the identification of compounds that inhibit nematode gene expression by targeting spliced leader trans-splicing.

Int J Parasitol Drugs Drug Resist 2019 Apr 5;10:28-37. Epub 2019 Apr 5.

School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen, AB25 2ZD, UK.

Infections with parasitic nematodes are among the most significant of the neglected tropical diseases affecting about a billion people living mainly in tropical regions with low economic activity. The most effective current strategy to control nematode infections involves large scale treatment programs with anthelmintic drugs. This strategy is at risk from the emergence of drug resistant parasites. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22113207183019
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http://dx.doi.org/10.1016/j.ijpddr.2019.04.001DOI Listing
April 2019
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Radiation Oncology. Optimal Health for All, Together. ESTRO vision, 2030.

Radiother Oncol 2019 Apr 11;136:86-97. Epub 2019 Apr 11.

European Society for Radiotherapy and Oncology, Brussels, Belgium; Antwerp Management School, Antwerp, Belgium.

Radiation oncology has seen considerable change since ESTRO adopted its previous vision statement, less than 10 years ago. The Society has now formulated a new vision for 2030, which remains dedicated to its mission, whilst adapting to evolving contexts and the transforming landscape. Aligning with the new vision, ESTRO has developed strategic priorities for the coming years. Read More

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http://dx.doi.org/10.1016/j.radonc.2019.03.031DOI Listing