3,562 results match your criteria European journal of internal medicine[Journal]


Syncope in the German Nationwide inpatient sample - Syncope in atrial fibrillation/flutter is related to pulmonary embolism and is accompanied by higher in-hospital mortality.

Eur J Intern Med 2019 Feb 13. Epub 2019 Feb 13.

Department of Cardiology, Cardiology I, University Medical Center Mainz (Johannes Gutenberg-University Mainz), Mainz, Germany.

Aims: Syncope is a common phenomenon in the general population. Although most of the causes are of benign origin, some comorbidities are accompanied by high mortality. We aimed to compare the in-hospital mortality of patients with syncope related to different comorbities and investigate the impact of syncope in patients with atrial fibrillation/flutter (AF). Read More

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http://dx.doi.org/10.1016/j.ejim.2019.02.005DOI Listing
February 2019

The effect of compression stocking on leg edema and discomfort during a 3-hour flight: A randomized controlled trial.

Eur J Intern Med 2019 Feb 6. Epub 2019 Feb 6.

Center for Perioperative Optimization, Department of Surgery, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark.

Background: Compression stockings reduce the risk of thromboembolic complications, leg edema, and edema-related pain and discomfort during long-haul flights. The aim of this study was to assess if compression stockings reduce leg edema, pain, and discomfort during a three-hour flight.

Methods: This randomized controlled trial had a paired design as participants were randomized to wear a compression stocking on one leg during a three-hour flight with the other leg acting as control. Read More

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http://dx.doi.org/10.1016/j.ejim.2019.01.013DOI Listing
February 2019

Association of renin-angiotensin system inhibitors with long-term outcomes in patients with systolic heart failure and moderate-to-severe kidney function impairment.

Eur J Intern Med 2019 Feb 5. Epub 2019 Feb 5.

Department of Cardiology, Sakakibara Heart Institute, Tokyo, Japan.

Purpose: Although guidelines recommend that patients with heart failure with reduced ejection fraction (HFrEF) should be treated with renin-angiotensin system (RAS) inhibitors, the long-term efficacy of RAS inhibitors in HFrEF patients with moderate-to-severe chronic kidney disease (CKD) remains unclear.

Methods: The present study included consecutive patients hospitalized for acute heart failure across five Japanese teaching hospitals. The impact of RAS inhibitors on 2-year all-cause mortality was evaluated in patients with an ejection fraction ≤40% and CKD, defined as an estimated glomerular filtration rate (eGFR) <45 mL/min/1. Read More

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http://dx.doi.org/10.1016/j.ejim.2019.01.014DOI Listing
February 2019
1 Read

Raynaud's phenomenon and inflammatory bowel disease: The possible role of microcirculation.

Eur J Intern Med 2019 Feb 5. Epub 2019 Feb 5.

Unidade de Doenças Auto-Imunes, Internal Medicine Department 7.2, Hospital Curry Cabral, Centro Hospitalar Universitário Lisboa Central, Lisboa, Portugal.

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http://dx.doi.org/10.1016/j.ejim.2019.02.001DOI Listing
February 2019
6 Reads

European and US guidelines for arterial hypertension: similarities and differences.

Eur J Intern Med 2019 Feb 4. Epub 2019 Feb 4.

Fondazione Umbra Cuore e Ipertensione-ONLUS and Division of Cardiology, Hospital S. Maria della Misericordia, Perugia, Italy.

Hypertension is one of the most common chronic diseases in adults and a leading cause of disability and mortality worldwide. Recently, new Guidelines for the diagnosis and management of hypertension have been released in Europe and in the United States, with changes regarding how to diagnose and treat the condition, and the extent to which intensive blood pressure control should be pursued. Important differences between the Guidelines exist in the classification of blood pressure levels and definition of treatment goals. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09536205193004
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http://dx.doi.org/10.1016/j.ejim.2019.01.016DOI Listing
February 2019
3 Reads

Haemoptysis as a presenting feature of hepatopulmonary disease.

Authors:
Oscar M P Jolobe

Eur J Intern Med 2019 Feb 4. Epub 2019 Feb 4.

Manchester Medical Society, Simon Building, Brunswick Street, Manchester M13 9PL, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.ejim.2019.01.020DOI Listing
February 2019

Frailty is associated with multimorbidities due to decreased physical reserve independent of age.

Eur J Intern Med 2019 Feb 2. Epub 2019 Feb 2.

Istanbul University Istanbul Medical School, Department of Internal Medicine, Division of Geriatrics, Turkey.

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http://dx.doi.org/10.1016/j.ejim.2019.01.017DOI Listing
February 2019

Influence of potassium levels on one-year outcomes in elderly patients with acute heart failure.

Eur J Intern Med 2019 02 26;60:24-30. Epub 2018 Oct 26.

Internal Medicine Department, IMIBIC/Hospital Reina Sofía, Universidad de Córdoba, Córdoba, Spain.

Background: Abnormal serum potassium levels (K) in patients with heart failure (HF) relate to worse prognosis. We evaluated whether admission K levels predict 1-year outcomes in elderly patients admitted for acute HF.

Methods: We evaluated 2865 patients aged >74 years from the RICA Spanish Heart Failure Registry, classified according to admission serum K levels: hyperkalemia (>5. Read More

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http://dx.doi.org/10.1016/j.ejim.2018.10.016DOI Listing
February 2019
2 Reads

Physiological reaction following contrast medium administration: What kind of reaction is this?

Eur J Intern Med 2019 Feb 1. Epub 2019 Feb 1.

Department of Diagnostic, Interventional and Pediatric Radiology, University Hospital of Bern, Inselspital, University of Bern, Bern, Switzerland; Department of BioMedical Research (DBMR), University of Bern, Bern, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.ejim.2019.01.015DOI Listing
February 2019

Persistent FDG/PET CT uptake in idiopathic retroperitoneal fibrosis helps identifying patients at a higher risk for relapse.

Eur J Intern Med 2019 Jan 31. Epub 2019 Jan 31.

Département de Médecine Interne, Hôpital Bichat, PRES Sorbonne Paris Cité, Assistance Publique Hôpitaux de Paris, Université Paris Diderot, Paris, France; Département Hospitalo-Universitaire FIRE (Fibrosis, Inflammation and Remodelling in Renal and Respiratory Diseases), Paris, France; INSERM U1149, Paris, France. Electronic address:

Background: The aim of this study was to evaluate the prognostic value of persistent retroperitoneal fibrosis FDG uptake using FDG/PET CT in patients with idiopathic retroperitoneal fibrosis (IRF).

Methods: In this monocentric retrospective cohort study, all patients admitted for IRF from January 2009 to December 2017 underwent a FDG/PET CT at diagnosis and during follow up. Metabolic activity of IRF was assessed by retroperitoneal fibrosis FDG uptake measured as maximal standardized uptake value (SUVmax). Read More

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http://dx.doi.org/10.1016/j.ejim.2019.01.019DOI Listing
January 2019
1 Read

Comorbidity assessment for mortality risk stratification in elderly patients with acute coronary syndrome.

Eur J Intern Med 2019 Jan 31. Epub 2019 Jan 31.

Servei de Cardiologia, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Barcelona, Spain.

Background: The Charlson's is the most used comorbidity index. It comprises 19 comorbidities, some of which are infrequent in elderly patients with acute coronary syndrome (ACS), while some others are manifestations of cardiac disease rather than comorbidities. Our goal was to simplify comorbidity assessment in elderly non-ST-segment elevation ACS patients. Read More

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http://dx.doi.org/10.1016/j.ejim.2019.01.018DOI Listing
January 2019
1 Read

Antidepressant prescription in acute myocardial infarction is associated with increased mortality 1 year after discharge.

Eur J Intern Med 2019 Jan 28. Epub 2019 Jan 28.

Department of Cardiology, Kantonsspital St. Gallen, Switzerland. Electronic address:

Aims: To assess the impact of antidepressant (AD) prescription at discharge on 1-year outcome of patients presenting with acute myocardial infarction (AMI) in Switzerland.

Methods: We used data from the AMIS Plus registry including patients admitted between March 2005 and August 2016 with AMI to a Swiss hospital who were followed up by telephone, 12 months after discharge. We compared patients who received AD medication at discharge with those who did not, with regard to baseline characteristics and outcomes in 1-year follow-ups using logistic regression. Read More

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http://dx.doi.org/10.1016/j.ejim.2018.12.003DOI Listing
January 2019

Performance of the CHADS-VASc score in predicting new onset atrial fibrillation during hospitalization for community-acquired pneumonia.

Eur J Intern Med 2019 Jan 25. Epub 2019 Jan 25.

Cardiomyopathy Unit, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy.

Background: Cardiovascular events are common during hospitalization for community-acquired pneumonia (CAP), with new onset atrial fibrillation (NOAF) being the second most relevant complication. In this study, we aimed to investigate the role of CHADS-VASc score in predicting NOAF during hospitalization for CAP.

Methods: Patients admitted for CAP were prospectively assessed using CHADS-VASc. Read More

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http://dx.doi.org/10.1016/j.ejim.2019.01.012DOI Listing
January 2019
1 Read

Insomnia symptoms in primary care: A prospective study focusing on prevalence of undiagnosed co-morbid sleep disordered breathing.

Eur J Intern Med 2019 Jan 25. Epub 2019 Jan 25.

SleepImage, 3513 Brighton Blvd, Suite 530, Denver, CO 80216, USA.

Objective: To determine prevalence of comorbid undiagnosed sleep disordered breathing (SDB) in chronic insomnia patients, using two complementary methods, one standard and one novel.

Methods: Using prospective design, adult patients diagnosed with chronic insomnia, treated with prescription pharmacological agents for >3 months without prior objective sleep evaluation or diagnosis of SDB were invited to participate. All patients recorded their sleep for two consecutive nights using level 3 home-sleep-apnea-test (HSAT) device to derive Respiratory Event Index (REI) for OSA diagnosis. Read More

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http://dx.doi.org/10.1016/j.ejim.2019.01.011DOI Listing
January 2019
1 Read

Risk of bleeding in hospitalized patients on anticoagulant therapy: Prevalence and potential risk factors.

Eur J Intern Med 2019 Jan 24. Epub 2019 Jan 24.

Erasmus University Medical Center, Rotterdam, Department of Hospital Pharmacy, The Netherlands.

Introduction: Bleeding is the most important complication of treatment with anticoagulant therapy. Although several studies have identified risk factors of bleeding in outpatients, no studies have been performed that evaluated prevalence and potential risk factors of bleeding in hospitalized patients treated with anticoagulant therapy.

Methods: The primary objective of this study was to determine the prevalence of bleeding in anticoagulant users during hospitalization. Read More

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http://dx.doi.org/10.1016/j.ejim.2019.01.008DOI Listing
January 2019

Differences in left ventricular geometry in hypertensive African-Europeans and Caucasian patients.

Eur J Intern Med 2019 Jan 24. Epub 2019 Jan 24.

Ospedale Riabilitativo di Alta Specializzazione, Cardiologia Riabilitativa, Motta Di Livenza, Italy.

Background: There are data showing race-related differences regarding left ventricular (LV) geometry in hypertensive patients. Several authors reported that concentric remodeling is the most common remodeling pattern in hypertensive African-Americans, and this pattern may be related to prognosis. There is little information about the LV remodeling patterns in hypertensive Africans that migrated to Europe, which might have different distributions from those seen in African-Americans. Read More

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http://dx.doi.org/10.1016/j.ejim.2019.01.006DOI Listing
January 2019

Cardiovascular events and de novo AF following Legionnaires disease.

Eur J Intern Med 2019 Jan 24. Epub 2019 Jan 24.

Department of Intensive Care Medicine, Centro Hospitalar São João, Portugal.

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http://dx.doi.org/10.1016/j.ejim.2019.01.010DOI Listing
January 2019
1 Read

Recommending marijuana use: Violation of the Hippocratic aphorism of "do good or do no harm".

Eur J Intern Med 2019 Jan 24. Epub 2019 Jan 24.

Red Cross Hospital, Athens, Greece.

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http://dx.doi.org/10.1016/j.ejim.2019.01.009DOI Listing
January 2019

In reply to "Small, however significant differences in the definition of physical frailty and sarcopenia".

Eur J Intern Med 2019 Jan 21. Epub 2019 Jan 21.

Fondazione Policlinico Universitario "Agostino Gemelli" IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.

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https://linkinghub.elsevier.com/retrieve/pii/S09536205193001
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http://dx.doi.org/10.1016/j.ejim.2019.01.007DOI Listing
January 2019
3 Reads

Tick-borne encephalitis in Europe: a brief update on epidemiology, diagnosis, prevention, and treatment.

Eur J Intern Med 2019 Jan 22. Epub 2019 Jan 22.

Department Health Science (DISSAL), University of Genoa, Genoa, Italy.

Tick-borne encephalitis (TBE) is an emerging health threat that is spreading in many parts of Europe. The mix of socio-economical, ecological and climatic factors as well as the presence of more susceptible hosts is actively contributing to the increasing number of TBE reported cases. TBE is an important cause of central nervous system (CNS) infection that can result in long-term neurological sequelae and even death. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09536205193001
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http://dx.doi.org/10.1016/j.ejim.2019.01.004DOI Listing
January 2019
2 Reads

Horizontal vs. vertical dose reduction of direct oral anticoagulants in patients with non-valvular atrial fibrillation: definition and implications for practice.

Authors:
Andrea Rubboli

Eur J Intern Med 2019 Jan 19. Epub 2019 Jan 19.

Department of Cardiovascular Diseases - AUSL Romagna, Division of Cardiology, Ospedale S. Maria delle Croci, Ravenna, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ejim.2019.01.005DOI Listing
January 2019

Cancer and atrial fibrillation. Author's reply.

Eur J Intern Med 2019 Jan 17. Epub 2019 Jan 17.

Cardiology Division, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Policlinico di Modena, Modena, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ejim.2019.01.002DOI Listing
January 2019
2 Reads

The hand of respiratory failure.

Eur J Intern Med 2019 Jan 15. Epub 2019 Jan 15.

Division of Pulmonary Medicine (NS), St. Agnes Hosipital, Baltimore, Maryland 21229, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ejim.2019.01.003DOI Listing
January 2019
1 Read
2.300 Impact Factor

Big trouble with temporary tattoos.

Eur J Intern Med 2019 Jan 10. Epub 2019 Jan 10.

Dermatology Department, University Hospitals Birmingham NHS Foundation Trust, Solihull Hospital, Lode Lane, Solihull B91 2JL, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.ejim.2018.12.005DOI Listing
January 2019

A painful rash after chemotherapy.

Eur J Intern Med 2019 Jan 4. Epub 2019 Jan 4.

Division of Medical Oncology, Department of Medicine and Geriatrics, United Christian Hospital, Hong Kong, China.

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https://linkinghub.elsevier.com/retrieve/pii/S09536205183047
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http://dx.doi.org/10.1016/j.ejim.2018.12.014DOI Listing
January 2019
2 Reads

Impact of Daylight Saving Time on circadian timing system: An expert statement.

Eur J Intern Med 2019 02 5;60:1-3. Epub 2019 Jan 5.

Department of Physiology, Faculty of Medicine, Center of Biomedical Research, Parque Tecnologico de Ciencias de la Salud, University of Granada, Granada, Spain.

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http://dx.doi.org/10.1016/j.ejim.2019.01.001DOI Listing
February 2019
6 Reads

A suspicious fracture.

Eur J Intern Med 2019 Jan 3. Epub 2019 Jan 3.

Department of Clinical and Experimental Medicine, University of Catania, Italy.

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http://dx.doi.org/10.1016/j.ejim.2018.12.009DOI Listing
January 2019

Hepatic-pulmonary disease.

Eur J Intern Med 2019 Jan 3. Epub 2019 Jan 3.

Infectious Diseases Section, University of Antioquia Medical School, Medellin, Colombia.

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http://dx.doi.org/10.1016/j.ejim.2018.12.013DOI Listing
January 2019
1 Read

Risk of hypoglycemia in hospitalized patients with diabetes mellitus.

Eur J Intern Med 2018 Dec 29. Epub 2018 Dec 29.

Department of Internal Medicine, Second Faculty of Medicine, Charles University, Prague, V Úvalu 84, 15000 Prague, Czech Republic.

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http://dx.doi.org/10.1016/j.ejim.2018.12.012DOI Listing
December 2018

Management of celiac disease in daily clinical practice: do not forget depression!

Eur J Intern Med 2018 Dec 28. Epub 2018 Dec 28.

Department of Internal Medicine, Gastroenterology and Hepatology, Alcohol Use Disorder Unit, Catholic University of Rome, Rome, Italy.

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http://dx.doi.org/10.1016/j.ejim.2018.12.011DOI Listing
December 2018

A young woman with left lower chest pain.

Eur J Intern Med 2018 Dec 26. Epub 2018 Dec 26.

Department of Internal Medicine, Shiraz University of Medical Sciences, Shiraz, Iran; Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address:

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http://dx.doi.org/10.1016/j.ejim.2018.12.007DOI Listing
December 2018
2.300 Impact Factor

Atypical rash.

Eur J Intern Med 2018 Dec 26. Epub 2018 Dec 26.

Infectious Diseases Section, Clinica Las Vegas, Medellín, Colombia.

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http://dx.doi.org/10.1016/j.ejim.2018.12.006DOI Listing
December 2018
1 Read

Nipple shadows.

Eur J Intern Med 2018 Dec 23. Epub 2018 Dec 23.

Department of Internal Medicine, Chungnam National University College of Medicine, Daejeon, South Korea. Electronic address:

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http://dx.doi.org/10.1016/j.ejim.2018.12.008DOI Listing
December 2018

Multimorbidity in middle age predicts more subsequent hospital admissions than in older age: A nine-year retrospective cohort study of 121,188 discharged in-patients.

Eur J Intern Med 2018 Dec 20. Epub 2018 Dec 20.

The Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Sha Tin, New Territories, Hong Kong. Electronic address:

Background: Previous research has suggested a differential short-term effect of multimorbidity on hospitalization by age, with younger groups affected more. This study compares the nine-year hospitalization pattern by age and multimorbidity status in a retrospective cohort of discharged in-patients, who represent a high-need portion of the population.

Methods: We examined routine clinical records of all patients aged 45+ years with chronic conditions discharged from public general hospitals in 2005 in Hong Kong. Read More

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http://dx.doi.org/10.1016/j.ejim.2018.12.001DOI Listing
December 2018

Impact of anemia as risk factor for major bleeding and mortality in patients with acute coronary syndrome.

Eur J Intern Med 2018 Dec 19. Epub 2018 Dec 19.

Department of Cardiology, Hospital General Universitario de Alicante, Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL), Alicante, Spain. Electronic address:

Background: Anemia is frequent in acute coronary syndrome (ACS) patients and is associated with worse clinical outcomes. We aimed to investigate the therapeutic strategies, the use of novel P2Y inhibitors, and the prognostic implication of anemia in a "real world" cohort of ACS patients.

Methods: This is an observational and prospective registry including 1717 ACS patients from three tertiary hospitals. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09536205183046
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http://dx.doi.org/10.1016/j.ejim.2018.12.004DOI Listing
December 2018
6 Reads

Computerized algorithms compared with a nephrologist's diagnosis of acute kidney injury in the emergency department.

Eur J Intern Med 2019 02 11;60:78-82. Epub 2018 Dec 11.

Division of Nephrology, Landspitali - The National University Hospital of Iceland, Reykjavik, Iceland. Electronic address:

Background: The aim of this study was to examine acute kidney injury (AKI) diagnosis based on different computerized algorithms compared with a nephrologist's diagnosis in patients visiting an emergency department (ED) of a university hospital.

Methods: In this retrospective study, we used electronic medical records at the University Hospital in Reykjavik to identify all patients aged ≥18 years, who presented to the ED in the year 2010 with an elevated serum creatinine (SCr) level. All SCr values were reviewed and a nephrologist determined whether AKI was present using the KDIGO SCr criteria and clinical data. Read More

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http://dx.doi.org/10.1016/j.ejim.2018.11.013DOI Listing
February 2019
1 Read

Mortality rate and risk factors for gastrointestinal bleeding in elderly patients.

Eur J Intern Med 2018 Dec 4. Epub 2018 Dec 4.

First Department of Internal Medicine, San Matteo Hospital Foundation, University of Pavia, Pavia, Italy.

Background: Gastrointestinal bleeding (GIB) is burdened by high mortality rate that increases with aging. Elderly patients may be exposed to multiple risk factors for GIB. We aimed at defining the impact of GIB in elderly patients. Read More

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http://dx.doi.org/10.1016/j.ejim.2018.11.003DOI Listing
December 2018
1 Read
2.300 Impact Factor

Non-invasive positive pressure ventilation in pneumonia outside Intensive Care Unit: An Italian multicenter observational study.

Eur J Intern Med 2019 01 25;59:21-26. Epub 2018 Oct 25.

Emergency Department Papa Giovanni XXIII Hospital, Bergamo, Italy.

Background And Objective: Non-Invasive Ventilation (NIV) represents a standard of care to treat some acute respiratory failure (ARF). Data on its use in pneumonia are lacking, especially in a setting outside the Intensive Care Unit (ICU). The aims of this study were to evaluate the use of NIV in ARF due to pneumonia outside the ICU, and to identify risk factors for in-hospital mortality. Read More

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http://dx.doi.org/10.1016/j.ejim.2018.09.025DOI Listing
January 2019
3 Reads

Management of celiac disease in daily clinical practice.

Eur J Intern Med 2018 Dec 5. Epub 2018 Dec 5.

Institute for Translational Immunology, Research Center for Immunotherapy (FZI), Johannes Gutenberg University (JGU) Medical Center, 55101 Mainz, Germany; Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

Celiac disease (CD) is the most common autoimmune enteropathy worldwide. In CD, dietary gluten triggers a T cell driven small intestinal inflammation in a subset of genetically predisposed subjects, expressing the HLA DQ2 and/or DQ8 genes on their antigen presenting cells. HLA DQ2/DQ8 can bind gluten peptides after their prior modification by the CD autoantigen, tissue transglutaminase (TG2). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09536205183046
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http://dx.doi.org/10.1016/j.ejim.2018.11.012DOI Listing
December 2018
10 Reads

Bringing complexity into clinical practice: An internistic approach.

Eur J Intern Med 2018 Dec 5. Epub 2018 Dec 5.

First Department of Internal Medicine, San Matteo Hospital Foundation, University of Pavia, Pavia, Italy.

Modern medicine, still largely focused on single diseases, is unprepared for managing clinical complexity (CC), which is an emerging issue. Ageing of the general population has favoured the occurrence of chronic diseases, which generate multimorbidity that has been considered for many years the main feature of CC. However, more recent studies have shown that CC is something more and different and originates from the dynamic interaction among the patient's intrinsic factors (age, gender, multimorbidity, frailty) as well as contextual factors (socioeconomic, behavioural, cultural, and environmental). Read More

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http://dx.doi.org/10.1016/j.ejim.2018.11.009DOI Listing
December 2018
2.300 Impact Factor

Autoimmune hemolytic anemia, autoimmune neutropenia and aplastic anemia in the elderly.

Eur J Intern Med 2018 12;58:77-83

UOC Oncoematologia, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico di Milano; Università degli Studi di Milano, Italy.

The physiology of the immune system involves morphologic and functional changes occurring along ageing, with a decrease in immune response and an increase in autoimmune phenomena, even in the absence of overt disese. Autoimmune cytopenias, namely autoimmune hemolytic anemia (AIHA), chronic idiopathic neutropenia (CIN) and aplastic anemia (AA), show different epidemiologic predilection, but are increasingly diagnosed in the elderly, where complications and comorbidities are more frequent. A systematic review of recent literature, shows that comorbidities as well as underlying deficiencies, medications, neoplasms, and, pathophysiologic chronic organ failures, frequently challenge the differential diagnosis in this setting and should always be evaluated and excluded. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09536205183023
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http://dx.doi.org/10.1016/j.ejim.2018.05.034DOI Listing
December 2018
5 Reads

Management of unfit elderly patients with chronic lymphocytic leukemia.

Eur J Intern Med 2018 12;58:7-13

German CLL Study Group (GCLLSG), Dept. I of Internal Medicine, Center of Integrated Oncology Cologne-Bonn, University Hospital Cologne, Cologne, Germany; Oncogeriatric Unit, Dept. of Geriatric Medicine, St. Marien Hospital, Cologne, Germany.

Chronic lymphocytic leukemia (CLL) is a disease characterized by an increasing incidence with age reaching 35/100,000 in patients over 85 years. Elderly CLL patients carry several challenges, which have to be considered particularly in advanced stages including a higher risk of infections and individual differences in comorbidities and geriatric syndromes. Although no specific tool for geriatric evaluation in CLL has been developed so far, several of them (e. Read More

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http://dx.doi.org/10.1016/j.ejim.2018.02.001DOI Listing
December 2018

Special problems in the management of elderly patients with multiple myeloma.

Eur J Intern Med 2018 12;58:64-69

Division of Hematology, University of Turin, Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino, Turin, Italy.

Multiple myeloma (MM) is a neoplastic disease typical of the elderly. Many steps forward have been made in the characterization of patients, and new treatment strategies are available today. Clinical trials represent a major point in the definition of standard treatment, although they usually include fit patients, while frail patients are commonly excluded. Read More

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http://dx.doi.org/10.1016/j.ejim.2018.05.027DOI Listing
December 2018

Myelodysplastic syndromes and acute myeloid leukemias in the elderly.

Eur J Intern Med 2018 12;58:28-32

Department of Medical Oncology, Inselspital, University Hospital and University of Bern, Bern, Switzerland. Electronic address:

Most patients above 60 years with acute myeloid leukemia (AML) will die from their disease. Nevertheless, the treatment concepts in elderly patients with myelodysplastic syndromes (MDS) and AML are rapidly evolving. A number of recent reports have identified better survival rates with intensive induction chemotherapy for patients up to 80 years, with the exception of patients with unfavorable genomic risk abnormalities or with major co-morbidities. Read More

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http://dx.doi.org/10.1016/j.ejim.2018.05.026DOI Listing
December 2018
1 Read

Chemotherapy-free and reduced intensity approaches in elderly patients with B-lineage acute lymphoblastic leukemia.

Eur J Intern Med 2018 12;58:22-27

Hematology, Department of Cellular Biotechnologies and Hematology, "Sapienza" University, Rome, Italy.

Management of older patients - defined by convention above the age of 60 years, but varying widely within study groups - with acute lymphoblastic leukemia (ALL) is still a challenge. The complete remission (CR) rate in these patients is lower than in other age groups and the percentage of deaths in induction or in CR remains high, ranging from 7 to 40%. Overall survival rates do not exceed 30%, depending on the age group included in the different trials group and on the follow-up duration. Read More

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http://dx.doi.org/10.1016/j.ejim.2018.05.028DOI Listing
December 2018

Hypoglycemia- simplifying the ways to predict an old problem in the general ward.

Eur J Intern Med 2019 02 28;60:13-17. Epub 2018 Nov 28.

Maccabi Health Services, Tel Aviv, Israel; Ben Gurion University, Beer Sheva, Israel.

Objective: To examine the association between hypoglycemic events and inpatient and outpatient mortality rates, and to characterize the profile of patients with diabetes who develop hypoglycemia during hospitalization in order to identify risk factors and potentially avoid it.

Research Design And Methods: This retrospective cohort study analyzed data of 3410 patients with diabetes hospitalized during 2012. The associations among biochemical measures, severity of hypoglycemia, inpatient length of stay, and mortality during hospitalization, one month and within one year after discharge were evaluated. Read More

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http://dx.doi.org/10.1016/j.ejim.2018.10.007DOI Listing
February 2019

Foreword.

Eur J Intern Med 2018 12 27;58. Epub 2018 Nov 27.

Institute of Oncology Research, Bellinzona, Switzerland; Oncology Institute of Southern Switzerland, Bellinzona, Switzerland.

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http://dx.doi.org/10.1016/j.ejim.2018.11.006DOI Listing
December 2018

Antipsychotics and severe hyponatremia: A Swedish population-based case-control study.

Eur J Intern Med 2019 02 1;60:71-77. Epub 2018 Dec 1.

Department of Clinical Science and Education at Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.

Background: Antipsychotics have been claimed to cause hyponatremia. The risk associated with individual antipsychotics, or groups (first-generation [FGAs] or second-generation [SGAs] antipsychotics), is not well-documented. The objective of this study was to investigate the association between antipsychotics and hospitalization due to hyponatremia. Read More

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http://dx.doi.org/10.1016/j.ejim.2018.11.011DOI Listing
February 2019
3 Reads

Handgrip strength, chronic physical conditions and physical multimorbidity in middle-aged and older adults in six low- and middle income countries.

Eur J Intern Med 2018 Nov 30. Epub 2018 Nov 30.

Research and Development Unit, Parc Sanitari Sant Joan de Déu, Universitat de Barcelona, Fundació Sant Joan de Déu, Dr. Antoni Pujadas, 42, Sant Boi de Llobregat, Barcelona 08830, Spain; Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Monforte de Lemos 3-5 Pabellón 11, Madrid 28029, Spain.

Purpose: Handgrip strength provides a clinically validated marker of overall health and mortality risk. There are however, no multi-national population-based studies investigating the associations between handgrip strength, chronic physical conditions, and physical multimorbidity (i.e. Read More

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http://dx.doi.org/10.1016/j.ejim.2018.11.007DOI Listing
November 2018
3 Reads
2.300 Impact Factor