302,222 results match your criteria European journal of endocrinology / European Federation of Endocrine Societies[Journal]


Innovative microscale workflow from fungi cultures to Cell Wall-Degrading Enzyme screening.

Microb Biotechnol 2019 Apr 20. Epub 2019 Apr 20.

EA 7394 - ICV - Institut Charles Viollette, Univ. Lille 1, ISA, INRA, Univ. Artois, Univ. Littoral Côte d'Opale, F-59000, Lille, France.

This study aimed at developing a complete miniaturized high-throughput screening workflow for the evaluation of the Cell Wall-Degrading Enzyme (CWDE) activities produced by any fungal strain directly cultivated on raw feedstock in a submerged manner. In this study, wheat straw was selected as model substrate as it represents an important carbon source but yet poorly valorised to yield high added value products. Fungi were grown in a microbioreactor in a high-throughput (HT) way to replace the fastidious shaking flask cultivations. Read More

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http://dx.doi.org/10.1111/1751-7915.13405DOI Listing

Comparison of overall survival and quality of life between patients undergoing anal reconstruction and patients undergoing traditional lower abdominal stoma after radical resection.

Clin Transl Oncol 2019 Apr 20. Epub 2019 Apr 20.

The Department of General Surgery, Second Hospital of Lanzhou University, No. 82, Cuiying Gate, Chengguan District, Lanzhou, 730030, Gansu, China.

Background: Miles procedure is often necessary for patients with low rectal carcinoma. However, this operation often affects the quality of life of patients, to evaluate the advantages of improved operation (anal reconstruction), the quality of life and survival between patients undergoing anal reconstruction and patients undergoing traditional lower abdominal stoma after radical resection were analyzed.

Methods: The clinical data of 43 patients with low situated rectal carcinoma were retrospectively analyzed. Read More

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http://dx.doi.org/10.1007/s12094-019-02106-xDOI Listing

Galectin-3, a novel endogenous TREM2 ligand, detrimentally regulates inflammatory response in Alzheimer's disease.

Acta Neuropathol 2019 Apr 20. Epub 2019 Apr 20.

Department of Experimental Medical Science, Experimental Neuroinflammation Laboratory, Lund University, 221 84, Lund, Sweden.

Alzheimer's disease (AD) is a progressive neurodegenerative disease in which the formation of extracellular aggregates of amyloid beta (Aβ) peptide, fibrillary tangles of intraneuronal tau and microglial activation are major pathological hallmarks. One of the key molecules involved in microglial activation is galectin-3 (gal3), and we demonstrate here for the first time a key role of gal3 in AD pathology. Gal3 was highly upregulated in the brains of AD patients and 5xFAD (familial Alzheimer's disease) mice and found specifically expressed in microglia associated with Aβ plaques. Read More

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http://dx.doi.org/10.1007/s00401-019-02013-zDOI Listing

Association of changes in bone mineral parameters with mortality in haemodialysis patients: insights from the ARO cohort.

Nephrol Dial Transplant 2019 Apr 21. Epub 2019 Apr 21.

Department of Nephrology, Division of Nephrology and Clinical Immunology, RWTH University of Aachen, Aachen, Germany.

Background: There is little information in haemodialysis (HD) patients on whether temporal changes in serum calcium, phosphate or intact parathyroid hormone (iPTH) are associated with mortality.

Methods: We analysed associations of phosphate, total calcium and iPTH with all-cause and cardiovascular mortality in 8817 incident HD patients from the European second Analyzing Data, Recognizing Excellence and Optimizing Outcomes (AROii) cohort enrolled in 2007-09, which were prospectively followed for a median of 3 years, using time-dependent Cox proportional hazards models. We evaluated changes in risk over time depending on changes in phosphate, calcium or iPTH. Read More

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https://academic.oup.com/ndt/advance-article/doi/10.1093/ndt
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http://dx.doi.org/10.1093/ndt/gfz060DOI Listing
April 2019
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Elucidation of causal direction between asthma and obesity: a bi-directional Mendelian randomization study.

Int J Epidemiol 2019 Apr 21. Epub 2019 Apr 21.

Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Background: Observational associations between asthma and obesity are well established, but inferring causality is challenging. We leveraged publicly available summary statistics to ascertain the causal direction between asthma and obesity via Mendelian randomization in European-ancestry adults.

Methods: We performed two-sample bi-directional Mendelian randomization analysis using publicly available genome-wide association studies summary statistics. Read More

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http://dx.doi.org/10.1093/ije/dyz070DOI Listing

New insight into human sweet taste: a genome-wide association study of the perception and intake of sweet substances.

Am J Clin Nutr 2019 Apr 21. Epub 2019 Apr 21.

Monell Chemical Senses Center, Philadelphia, PA.

Background: Individual differences in human perception of sweetness are partly due to genetics; however, which genes are associated with the perception and the consumption of sweet substances remains unclear.

Objective: The aim of this study was to verify previous reported associations within genes involved in the peripheral receptor systems (i.e. Read More

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http://dx.doi.org/10.1093/ajcn/nqz043DOI Listing

Habitual coffee consumption and risk of falls in 2 European cohorts of older adults.

Am J Clin Nutr 2019 Apr 21. Epub 2019 Apr 21.

Department of Preventive Medicine and Public Health, School of Medicine, Universidad Autónoma de Madrid, IdiPaz (Instituto de Investigación Sanitaria Hospital Universitario La Paz), and CIBERESP (CIBER of Epidemiology and Public Health), Madrid, Spain.

Background: Habitual coffee consumption has been associated with lower risk of type 2 diabetes, cardiovascular disease, and sarcopenia, which are strong risk factors of falls. In addition, caffeine intake stimulates attention and vigilance, and reduces reaction time. Therefore, a protective effect of coffee on the risk of falling can be hypothesized. Read More

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http://dx.doi.org/10.1093/ajcn/nqy369DOI Listing

Longitudinal access and exposure to green-blue spaces and individual-level mental health and well-being: protocol for a longitudinal, population-wide record-linked natural experiment.

BMJ Open 2019 Apr 20;9(4):e027289. Epub 2019 Apr 20.

Swansea University Medical School, Swansea University, Swansea, UK.

Introduction: Studies suggest that access and exposure to green-blue spaces (GBS) have beneficial impacts on mental health. However, the evidence base is limited with respect to longitudinal studies. The main aim of this longitudinal, population-wide, record-linked natural experiment, is to model the daily lived experience by linking GBS accessibility indices, residential GBS exposure and health data; to enable quantification of the impact of GBS on well-being and common mental health disorders, for a national population. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-027289DOI Listing

International prospective observational study on intracranial pressure in intensive care (ICU): the SYNAPSE-ICU study protocol.

BMJ Open 2019 Apr 20;9(4):e026552. Epub 2019 Apr 20.

Department of Public Health, Erasmus MC, Rotterdam, Netherlands.

Introduction: Intracranial pressure (ICP) monitoring is commonly used in neurocritical care patients with acute brain injury (ABI). Practice about indications and use of ICP monitoring in patients with ABI remains, however, highly variable in high-income countries, while data on ICP monitoring in low and middle-income countries are scarce or inconsistent. The aim of the SYNAPSE-ICU study is to describe current practices of ICP monitoring using a worldwide sample and to quantify practice variations in ICP monitoring and management in neurocritical care ABI patients. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-026552DOI Listing
April 2019
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Epoetin alfa for the treatment of myelodysplastic syndrome-related anemia: A review of clinical data, clinical guidelines, and treatment protocols.

Leuk Res 2019 Mar 27;81:35-42. Epub 2019 Mar 27.

Institut Multidisciplinaire d'Oncologie, Clinique de Genolier, Genolier, Switzerland. Electronic address:

Myelodysplastic syndromes (MDS) are characterized by ineffective hematopoiesis, leading to hematopoietic precursor cell apoptosis and peripheral blood cytopenias. Anemia is the most frequently experienced cytopenia and is the main cause of MDS symptoms, with fatigue and dyspnea contributing to reduced quality of life and increased morbidity. As MDS disease course and prognosis is influenced by disease factors, prognostic scoring systems have been developed for MDS to aid clinical and therapeutic decisions following diagnosis. Read More

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http://dx.doi.org/10.1016/j.leukres.2019.03.006DOI Listing

The role of renewable energy, immigration and real income in environmental sustainability target. Evidence from Europe largest states.

Sci Total Environ 2019 Apr 13;674:307-315. Epub 2019 Apr 13.

Faculty of Business and Economics, Department of Economics, Eastern Mediterranean University, via Mersin 10, Famagusta, North Cyprus, Turkey. Electronic address:

In spite of the continued deployment of technologies, innovations toward addressing the challenges of global warming, forecasting and sustaining quality environment have remained the herculean endeavour of the advanced states. Also, being migrants' destinations, resulting from the availability of economic opportunities, the target of attaining low-carbon, energy efficiency, and the cleaner atmospheric environment by these advanced economies is further bewildered. In that light, we investigate the impact of renewable energy consumption and migration on the carbon dioxide emissions of the panel of European Union's largest economies of France, Germany, and the United Kingdom over the period of 1990-2016. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.04.163DOI Listing

Temperament and character influence on depression treatment outcome.

J Affect Disord 2019 Apr 9;252:464-474. Epub 2019 Apr 9.

Department of Biomedical and NeuroMotor Sciences, University of Bologna, Italy. Electronic address:

Background: personality features have been repeatedly associated with depression treatment outcome in Major Depressive Disorder (MDD), however conclusive results are still lacking. Moreover, as for Bipolar Disorder (BD), results are only few and preliminary.

Aim: the aim of the present study was to perform an exploratory investigation of the influence of personality traits as assessed by the Temperament and Character Inventory (TCI), on principal depression treatment outcomes (non remission, non response and resistance). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01650327183178
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http://dx.doi.org/10.1016/j.jad.2019.04.031DOI Listing
April 2019
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Mental wellbeing, air pollution and the ecological state.

Health Place 2019 Apr 18;57:82-91. Epub 2019 Apr 18.

Department of Sociology, Ghent University, Belgium.

The ecological State puts environmental considerations at the centre of its actions. To explores its role in the association between air pollution and mental wellbeing, this work employs a hierarchical three-level analysis on the third wave (2011-2012) of the European Quality of Life Survey (N = 25007, N = 216, N = 20). It uses a classification of Environmental Governance Regimes, subjective and objective indicators of air pollution, and the WHO-5 index of mental wellbeing. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13538292183110
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http://dx.doi.org/10.1016/j.healthplace.2019.03.003DOI Listing
April 2019
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Hydrophobic-interaction chromatography for purification of influenza A and B virus.

J Chromatogr B Analyt Technol Biomed Life Sci 2019 Apr 1;1117:103-117. Epub 2019 Apr 1.

Bioprocess Engineering, Max Planck Institute for Dynamics of Complex Technical Systems, 39106 Magdeburg, Germany; Chair of Bioprocess Engineering, Otto-von-Guericke University, 39106 Magdeburg, Germany.

Options for hydrophobic-interaction chromatography (HIC) for purification of cell culture-derived influenza A and B virus have been assessed using a 96-well plate format using a semi-high-throughput approach. Follow-up experiments at preparative scale were used to characterize dynamic binding capacity, viral hemagglutinin protein (HA protein) recovery, and the influence of influenza virus (IV) strains on yield and contamination levels. Virus recoveries of up to 96% with a residual DNA level of about 1. Read More

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http://dx.doi.org/10.1016/j.jchromb.2019.03.037DOI Listing

[Positioning for the management of arterial hypertension in Primary Care from the critical analysis of the American (2017) and European (2018) guidelines. Spanish Society of Primary Care Physicians (SEMERGEN)].

Semergen 2019 Apr 18. Epub 2019 Apr 18.

Servicio de Cardiología, Hospital Universitario La Paz, Madrid, España.

The Scientific Societies of Primary Care, being the area in which there is a considerable prevalence of Arterial Hypertension (AHT), need to periodically evaluate the international guidelines for its management. This is particularly relevant when disparate guidelines make it difficult to make decisions in daily clinical practice. The present document has as its aim to analyse the changes and new developments proposed in the guidelines of the American College of Cardiology and the American Heart Association (ACC/AHA 2017), as well as in the guidelines of the European Society of Cardiology and European Society of Hypertension (ESC/ESH 2018). Read More

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http://dx.doi.org/10.1016/j.semerg.2019.02.003DOI Listing

[Influence of post-traumatic stress disorder on asthma].

Presse Med 2019 Apr 17. Epub 2019 Apr 17.

Université de Poitiers, centre hospitalier Henri-Laborit, unité de recherche clinique, 86021 Poitiers, France.

Introduction: Exposure to a traumatic event may not only lead to a large variety of mental disorders, such as post-traumatic stress disorder (PTSD) but also respiratory symptoms and/or respiratory diseases, as asthma.

Objectives: Systematic literature review of data on the impact of post-traumatic stress disorder on asthma.

Documentary Sources: Medline, on the period 1980-2018 with the following keywords: "PTSD" or "post-traumatic stress disorder" or "post-traumatic stress disorder" and "asthma", limits "title/abstract"; the selected languages were English or French. Read More

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http://dx.doi.org/10.1016/j.lpm.2019.03.002DOI Listing

Safety Assessment of Immune-Mediated Adverse Reactions to Novel Food Proteins.

Trends Biotechnol 2019 Apr 17. Epub 2019 Apr 17.

Instituto de Investigación en Ciencias de la Alimentación, CIAL (CSIC-UAM), C/ Nicolás Cabrera, 9, Campus de la Universidad Autónoma de Madrid, 28049 Madrid, Spain.

Current international guidelines for the risk assessment of biotechnology-derived foods date back to 2003. We present new strategies and directions for assessing immune adverse reactions to novel food proteins. Understanding genetic factors involved in food allergy and the role of the gastrointestinal tract will streamline risk assessment strategies. Read More

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http://dx.doi.org/10.1016/j.tibtech.2019.03.010DOI Listing

Infectious human papillomavirus virions in semen reduce clinical pregnancy rates in women undergoing intrauterine insemination.

Fertil Steril 2019 Apr 17. Epub 2019 Apr 17.

Genk Institute for Fertility Technology, ZOL Hospitals, Genk, Belgium; Faculty of Medicine and Life Sciences, Hasselt University, Hasselt, Belgium.

Objective: To study the influence of human papillomavirus (HPV) virions present in different sperm fractions of male partners of women undergoing IUI on fertility outcome.

Design: Prospective noninterventional multicenter study.

Setting: Inpatient hospital fertility centers. Read More

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http://dx.doi.org/10.1016/j.fertnstert.2019.02.002DOI Listing

An updated European Organisation for Research and Treatment of Cancer (EORTC) protocol for pathological evaluation of sentinel lymph nodes for melanoma.

Eur J Cancer 2019 Apr 17;114:1-7. Epub 2019 Apr 17.

Department of Surgical Oncology, Netherlands Cancer Institute Antoni van Leeuwenhoek, Amsterdam, the Netherlands.

The sentinel lymph node (SLN) biopsy is a highly accurate staging procedure and the most important prognostic factor in melanoma patients. The European Organisation for Research and Treatment of Cancer (EORTC) Melanoma Group aimed to design an updated evolved SLN protocol for the histopathological workup and reporting. We herein recommend extending the distance between steps according to the short axis dimension of the lymph node and optimise both conventional sectioning and staining procedures including immunohistochemistry. Read More

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http://dx.doi.org/10.1016/j.ejca.2019.03.010DOI Listing

High-resolution large-area imaging of nanoscale structure and mineralization of a sclerosing osteosarcoma in human bone.

J Struct Biol 2019 Apr 17. Epub 2019 Apr 17.

Department of Material Sciences and Process Engineering, University of Natural Resources and Life Sciences, Vienna, Austria.

Osteosarcoma is the most common primary bone cancer type in humans. It is predominantly found in young individuals, with a second peak later in life. The tumour is formed by malignant osteoblasts and consists of collagenous, sometimes also mineralized, bone matrix. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10478477193007
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http://dx.doi.org/10.1016/j.jsb.2019.04.012DOI Listing
April 2019
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Impact of the replacement of dietary fish oil by animal fats and environmental salinity on the metabolic response of European Seabass (Dicentrarchus labrax).

Comp Biochem Physiol B Biochem Mol Biol 2019 Apr 17. Epub 2019 Apr 17.

CIIMAR-Interdisciplinary Centre of Marine and Environmental Research, University of Porto, Portugal. Electronic address:

The replacement of fish oil (FO) with other lipid sources (e.g. animal fats, AF) in aquafeeds improves the sustainability of aquaculture, even though alternatives have different fatty acid (FA) profiles. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10964959183032
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http://dx.doi.org/10.1016/j.cbpb.2019.04.004DOI Listing
April 2019
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30 Years (and More) of Hair Research Societies.

J Am Acad Dermatol 2019 Apr 17. Epub 2019 Apr 17.

The Society for Hair Science Research (Japan), Okubo 2-4-12, Shinjuku-ku, Shunkosha, Co. 169-0072 Tokyo, Japan.

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http://dx.doi.org/10.1016/j.jaad.2019.04.028DOI Listing

Correlations between Computational Fluid Dynamics and clinical evaluation of nasal airway obstruction due to septal deviation: an observational study.

Clin Otolaryngol 2019 Apr 20. Epub 2019 Apr 20.

APHM, Department of Oto-Rhino-Laryngology and Head and Neck Surgery, La Conception University Hospital, 13385, Marseille Cedex, France.

Objectives: The primary objective of this study was to determine how Computational Fluid Dynamics (CFD) could be correlated to clinical evaluation of Nasal Airway Obstruction (NAO) in a population of patients with symptomatic septal deviation (SD). The secondary objective was to determine whether CFD could define which side was the more obstructed.

Design: This was an observational study. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/coa.13344
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http://dx.doi.org/10.1111/coa.13344DOI Listing
April 2019
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Photosafety of the Antidiabetic Drug Sitagliptin.

Photodermatol Photoimmunol Photomed 2019 Apr 20. Epub 2019 Apr 20.

Instituto de Investigación Sanitaria (IIS) La Fe, Hospital Universitari i Politècnic La Fe, Avenida de Fernando Abril Martorell 106, 46026, Valencia, Spain.

Sitagliptin (SIT) is a dipeptidyl-peptidase inhibitor, used as an oral hypoglycaemic drug. It is often combined with metformin (MET), for the treatment of type 2 diabetes mellitus (T2DM), which is a chronic disease of high prevalence. The European Medicines Agency (EMA) reported, in 2007, several side effects related to SIT (Januvia ); however photosensitivity was not included as part of its adverse reactions. Read More

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http://dx.doi.org/10.1111/phpp.12475DOI Listing
April 2019
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Perception of Western governments' hostility to Islam among European Muslims before and after ISIS: the important roles of residential segregation and education.

Br J Sociol 2019 Apr 19. Epub 2019 Apr 19.

University of Oklahoma.

Perception of Western governments' hostility to Islam is one of the indicating features of Islamic fundamentalism and, in some cases, is serving as a pull to join extremist groups. In this paper, using data from two waves of a cross-national survey, we investigate what affects European Muslims' opinions about Western governments. We find that residential segregation is associated with perceived hostility of Western governments to Islam. Read More

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http://dx.doi.org/10.1111/1468-4446.12673DOI Listing

Missing the Match Might Not Cost You the Game: Primer-Template Mismatches Studied in Different Hepatitis A Virus Variants.

Food Environ Virol 2019 Apr 19. Epub 2019 Apr 19.

European Union Reference Laboratory (EURL) for Foodborne Viruses, National Food Agency, Hamnesplanaden 5, 453 23, Uppsala, Sweden.

Mismatches between template sequences and reverse transcription (RT) or polymerase chain reaction (PCR) primers can lead to underestimation or false negative results during detection and quantification of sequence-diverse viruses. We performed an in silico inclusivity analysis of a widely used RT-PCR assay for detection of hepatitis A virus (HAV) in food, described in ISO 15216-1. One of the most common mismatches found was a single G (primer) to U (template) mismatch located at the terminal 3'-end of the reverse primer region. Read More

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http://link.springer.com/10.1007/s12560-019-09387-z
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http://dx.doi.org/10.1007/s12560-019-09387-zDOI Listing
April 2019
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Overweight in family members of probands with ADHD.

Eur Child Adolesc Psychiatry 2019 Apr 19. Epub 2019 Apr 19.

Karakter Child and Adolescent Psychiatry University Center, Reinier Postlaan 12, 6525 GC, Nijmegen, The Netherlands.

The widely reported association between ADHD and overweight may be attributable to genetic and environmental factors also present in unaffected family members. Therefore, the purpose of this study was to examine the association between ADHD and overweight within families. A cohort was used of families with at least one member with ADHD, recruited as part of the Dutch node of the International Multicenter ADHD Genetics (IMAGE) study, with assessments taking place between 2003 and 2006, 2009 and 2012, and 2013 and 2015. Read More

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http://link.springer.com/10.1007/s00787-019-01331-7
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http://dx.doi.org/10.1007/s00787-019-01331-7DOI Listing
April 2019
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Cardiovascular Risk in Type 1 Diabetes Mellitus.

Diabetes Ther 2019 Apr 19. Epub 2019 Apr 19.

Cardiovascular Research Group, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, M13 9WU, UK.

Type 1 diabetes mellitus (T1DM) is associated with premature cardiovascular disease (CVD), but the underlying mechanisms remain poorly understood. The American Diabetes Association and the European Association for the Study of Diabetes recently updated their position statement on the management of type 2 diabetes mellitus (T2DM) to include additional focus on cardiovascular risk; improved management of risk factors in T1DM is also needed. There are important differences in the pathophysiology of CVD in T1DM and T2DM. Read More

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http://dx.doi.org/10.1007/s13300-019-0612-8DOI Listing

Evaluation of the draft guidelines proposed by EMA and FDA for the clinical diagnosis of acute uncomplicated cystitis in women.

World J Urol 2019 Apr 19. Epub 2019 Apr 19.

Department of Urology, Pediatric Urology and Andrology, Justus-Liebig-University, Rudolph-Buchheim Str.7, 35392, Giessen, Germany.

Purpose: To reassess the diagnostic values of the "draft" guidelines for the clinical diagnosis of acute uncomplicated cystitis (AC), recently proposed by US Food and Drug Administration (FDA) and European Medicines Agency (EMA).

Methods: The data of 517 female respondents (patients with acute cystitis and controls) derived from the e-USQOLAT database were analyzed and used for the validation of proposed "draft" guidelines of FDA and EMA, compared to the Acute Cystitis Symptom Score (ACSS) questionnaire. The diagnostic values of the proposals concerning signs, symptoms and their severity were assessed and compared. Read More

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http://dx.doi.org/10.1007/s00345-019-02761-3DOI Listing

The dynamics of self-control: within-participant modeling of binary food choices and underlying decision processes as a function of restrained eating.

Psychol Res 2019 Apr 19. Epub 2019 Apr 19.

Department of Psychology, Centre for Cognitive Neuroscience, Paris-Lodron-University of Salzburg, Hellbrunner Straße 34, 5020, Salzburg, Austria.

Successful self-control during food choice might require inhibition of impulses to avoid indulging in tempting but calorie-dense foods, and this might particularly apply to individuals restraining their food intake. Adopting a novel within-participant modeling approach, we tested 62 females during a mouse-tracking based binary food choice task. Subsequent ratings of foods on palatability, healthiness, and calorie density were modeled as predictors for both decision outcome (choice) and decision process (measures of self-control conflict) while considering the moderating role of restrained eating. Read More

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http://link.springer.com/10.1007/s00426-019-01185-3
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http://dx.doi.org/10.1007/s00426-019-01185-3DOI Listing
April 2019
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Cross-sectional association between blood pressure status and atrial fibrillation in an elderly Chinese population.

Am J Hypertens 2019 Apr 20. Epub 2019 Apr 20.

Center for Epidemiological Studies and Clinical Trials, Shanghai Key Laboratory of Hypertension, The Shanghai Institute of Hypertension, Department of Hypertension, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Objective: Atrial fibrillation(AF) and hypertension are prevalent chronic disease conditions in the elderly. In the present cross-sectional study, we investigated the association between blood pressure (BP) and AF in an elderly Chinese population.

Method: Our elderly (≥65 years) subjects were residents recruited from 6 communities in Shanghai from 2006 to 2017. Read More

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http://dx.doi.org/10.1093/ajh/hpz060DOI Listing

Applicability of the mutation-selection balance model to population genetics of heterozygous protein-truncating variants in humans.

Mol Biol Evol 2019 Apr 19. Epub 2019 Apr 19.

Brigham and Women's Hospital, Division of Genetics, Harvard Medical School, Boston, MA, USA.

The fate of alleles in the human population is believed to be highly affected by the stochastic force of genetic drift. Estimation of the strength of natural selection in humans generally necessitates a careful modeling of drift including complex effects of the population history and structure. Protein-truncating variants (PTVs) are expected to evolve under strong purifying selection and to have a relatively high per-gene mutation rate. Read More

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http://dx.doi.org/10.1093/molbev/msz092DOI Listing

5-HTT independent effects of fluoxetine on neuroplasticity.

Sci Rep 2019 Apr 19;9(1):6311. Epub 2019 Apr 19.

Institut de Psychiatrie et Neurosciences de Paris, Inserm, U 1266, Paris, France.

Selective serotonin reuptake inhibitors are among the most prescribed antidepressants. Fluoxetine is the lead molecule which exerts its therapeutic effects, at least in part, by promoting neuroplasticity through increased brain-derived neurotrophic factor (BDNF)/tropomyosin-related receptor kinase B (TrkB) signalling. It is unclear however, to which extent the neuroplastic effects of fluoxetine are solely mediated by the inhibition of the serotonin transporter (5-HTT). Read More

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http://www.nature.com/articles/s41598-019-42775-w
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http://dx.doi.org/10.1038/s41598-019-42775-wDOI Listing
April 2019
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Interaction of RNA viruses of the natural virome with the African malaria vector, Anopheles coluzzii.

Sci Rep 2019 Apr 19;9(1):6319. Epub 2019 Apr 19.

Department of Parasites and Insect Vectors, Unit of Genetics and Genomics of Insect Vectors, Institut Pasteur, Paris, 75724 CEDEX 15, France.

Mosquitoes are colonized by a little-studied natural virome. Like the bacterial microbiome, the virome also probably influences the biology and immunity of mosquito vector populations, but tractable experimental models are lacking. We recently discovered two novel viruses in the virome of wild Anopheles and in colonies of the malaria vector Anopheles coluzzii: Anopheles C virus and Anopheles cypovirus. Read More

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http://dx.doi.org/10.1038/s41598-019-42825-3DOI Listing

Fingerprinting of Proteins that Mediate Quagga Mussel Adhesion using a De Novo Assembled Foot Transcriptome.

Sci Rep 2019 Apr 19;9(1):6305. Epub 2019 Apr 19.

Institute of Biomaterials & Biomedical Engineering, University of Toronto, Toronto, ON, Canada.

The European freshwater mollusk Dreissena bugensis (quagga mussel), an invasive species to North America, adheres to surfaces underwater via the byssus: a non-living protein 'anchor'. In spite of its importance as a biofouling species, the sequence of the majority of byssal proteins responsible for adhesion are not known, and little genomic data is available. To determine protein sequence information, we utilized next-generation RNA sequencing and de novo assembly to construct a cDNA library of the quagga mussel foot transcriptome, which contains over 200,000 transcripts. Read More

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http://www.nature.com/articles/s41598-019-41976-7
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http://dx.doi.org/10.1038/s41598-019-41976-7DOI Listing
April 2019
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Component of splicing factor SF3b plays a key role in translational control of polyribosomes on the endoplasmic reticulum.

Proc Natl Acad Sci U S A 2019 Apr 19. Epub 2019 Apr 19.

Nippi Research Institute of Biomatrix, Toride, 302-0017 Ibaraki, Japan;

One of the morphological hallmarks of terminally differentiated secretory cells is highly proliferated membrane of the rough endoplasmic reticulum (ER), but the molecular basis for the high rate of protein biosynthesis in these cells remains poorly documented. An important aspect of ER translational control is the molecular mechanism that supports efficient use of targeted mRNAs in polyribosomes. Here, we identify an enhancement system for ER translation promoted by p180, an integral ER membrane protein we previously reported as an essential factor for the assembly of ER polyribosomes. Read More

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http://dx.doi.org/10.1073/pnas.1901742116DOI Listing

MAPK pathway and B cells overactivation in multiple sclerosis revealed by phosphoproteomics and genomic analysis.

Proc Natl Acad Sci U S A 2019 Apr 19. Epub 2019 Apr 19.

Center of Neuroimmunology, Institut d'Investigacions Biomèdiques August Pi Sunyer, Barcelona 08036, Spain;

Dysregulation of signaling pathways in multiple sclerosis (MS) can be analyzed by phosphoproteomics in peripheral blood mononuclear cells (PBMCs). We performed in vitro kinetic assays on PBMCs in 195 MS patients and 60 matched controls and quantified the phosphorylation of 17 kinases using xMAP assays. Phosphoprotein levels were tested for association with genetic susceptibility by typing 112 single-nucleotide polymorphisms (SNPs) associated with MS susceptibility. Read More

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http://dx.doi.org/10.1073/pnas.1818347116DOI Listing
April 2019
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Dietary calories and lipids synergistically shape adipose tissue cellularity during postnatal growth.

Mol Metab 2019 Apr 5. Epub 2019 Apr 5.

DKFZ Junior Group Metabolism and Stem Cell Plasticity, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg 69120, Germany. Electronic address:

Objective: The susceptibility to abdominal obesity and the metabolic syndrome is determined to a substantial extent during childhood and adolescence, when key adipose tissue characteristics are established. Although the general impact of postnatal nutrition is well known, it is not clear how specific dietary components drive adipose tissue growth and how this relates to the risk of metabolic dysfunction in adulthood.

Methods: Adipose tissue growth including cell proliferation was analyzed in juvenile mice upon dietary manipulation with in vivo nucleotide labeling. Read More

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http://dx.doi.org/10.1016/j.molmet.2019.03.012DOI Listing

Predictive factors of unexpected lymphatic drainage pathways in early-stage cervical cancer.

Gynecol Oncol 2019 Apr 16. Epub 2019 Apr 16.

Gynecologic and Breast Oncologic Surgery Department, Georges Pompidou European Hospital, Paris, France; Paris Descartes University, Sorbonne Paris Cité, Faculty of Medicine, Paris, France.

Objectives: The purpose of this study was to describe sentinel lymph nodes (SLN) topography in patients with early-stage cervical cancer and to determine factors associated with atypical lymphatic drainage pathway (LDP).

Methods: We analyzed the data of two prospective multicentric trials on SLN biopsy for cervical cancer (SENTICOL I and II) in women undergoing surgery for early-stage cervical cancer. SLN detection was realized with a combined labeling technique (Patent blue and radioactive tracer). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00908258193050
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http://dx.doi.org/10.1016/j.ygyno.2019.04.008DOI Listing
April 2019
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Time trends of short-term mortality for octogenarians undergoing a colorectal resection in North Europe.

Eur J Surg Oncol 2019 Apr 9. Epub 2019 Apr 9.

Department of Surgical Oncology, Leiden University Medical Center, the Netherlands. Electronic address:

Background: Decreased cancer specific survival in older colorectal patients is mainly due to mortality in the first year, emphasizing the importance of the first postoperative year. This study aims to gain an overview and time trends of short-term mortality in octogenarians (≥80 years) with colorectal cancer across four North European countries.

Methods: Patients of 80 years or older, operated for colorectal cancer (stage I-III) between 2005 and 2014, were included. Read More

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http://dx.doi.org/10.1016/j.ejso.2019.03.041DOI Listing

The transposition of the Patients' Rights Directive in Finland-Difficulties encountered.

Health Policy 2019 Mar 8. Epub 2019 Mar 8.

Tampere University, Faculty of Social Sciences, P.O. Box 100, 33014, Finland; National Institute for Health and Welfare (THL), Department of Health and Social Care Systems, P.O. Box 30, 00271, Helsinki, Finland. Electronic address:

The Directive on the application on patient rights' in cross-border healthcare (2011/24/EC) was transposed in Finland by the Act on Cross-Border Health Care (1201/2013), which entered into force on 1 January 2014. A new reimbursement model for cross-border health care costs was designed. The Finnish legislator considered the chosen reimbursement model to correspond both with the aims of the Directive as well as to the functioning of the national health care scheme. Read More

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http://dx.doi.org/10.1016/j.healthpol.2019.02.008DOI Listing

Functional Characterization of Clinically-Relevant Rare Variants in Identified in a Gout and Hyperuricemia Cohort.

Cells 2019 Apr 18;8(4). Epub 2019 Apr 18.

Institute of Rheumatology, 128 50 Prague 2, Czech Republic.

ATP-binding cassette subfamily G member 2 (ABCG2) is a physiologically important urate transporter. Accumulating evidence demonstrates that congenital dysfunction of ABCG2 is an important genetic risk factor in gout and hyperuricemia; recent studies suggest the clinical significance of both common and rare variants of ABCG2. However, the effects of rare variants of on the risk of such diseases are not fully understood. Read More

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http://dx.doi.org/10.3390/cells8040363DOI Listing

Sexual Distress in Patients with Hidradenitis Suppurativa: A Cross-Sectional Study.

J Clin Med 2019 Apr 18;8(4). Epub 2019 Apr 18.

Dermatology, Hidradenitis Suppurativa Clinic, Hospital Universitario Virgen de las Nieves, Avenida de las Fuerzas Armadas 2, 18014 Granada, Spain.

Hidradenitis suppurativa (HS) is a chronic auto-inflammatory skin disease with a great impact in quality of life. However, there is little research about the impact of HS on sex life. The aims of this study are to describe the frequency of sexual distress (SD) in patients with HS and to explore potentially associated epidemiological and clinical factors. Read More

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https://www.mdpi.com/2077-0383/8/4/532
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http://dx.doi.org/10.3390/jcm8040532DOI Listing
April 2019
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Reassessment of Viroid RNA Cytosine Methylation Status at the Single Nucleotide Level.

Viruses 2019 Apr 18;11(4). Epub 2019 Apr 18.

Istituto per la Protezione Sostenibile delle Piante (CNR), 70126 Bari, Italy.

Composed of a few hundreds of nucleotides, viroids are infectious, circular, non-protein coding RNAs able to usurp plant cellular enzymes and molecular machineries to replicate and move in their hosts. Several secondary and tertiary RNA structural motifs have been implicated in the viroid infectious cycle, but whether modified nucleotides, such as 5C-methylcytosine (mC), also play a role has not been deeply investigated so far. Here, the possible existence of mC in both RNA polarity strands of potato spindle tuber viroid and avocado sunblotch viroid -which are representative members of the nucleus- and chloroplast-replicating viroids, respectively- has been assessed at single nucleotide level. Read More

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http://dx.doi.org/10.3390/v11040357DOI Listing

Outcome of a Modified Perceval Implantation Technique.

Thorac Cardiovasc Surg 2019 Apr 19. Epub 2019 Apr 19.

Department of Cardiac Surgery, University Hospital Oldenburg, European Medical School Oldenburg-Groningen, Carl von Ossietzky University Oldenburg, Oldenburg, Germany.

Background:  In our institution, we developed a modification of the standard implantation technique of the Perceval sutureless aortic prosthesis (LivaNova, London, United Kingdom) that involves the usage of snuggers for the guiding sutures during valve deployment. The technique has been described elsewhere. In this article, we present the results of our initial case series comprising 128 consecutive patients. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0039-1685512
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http://dx.doi.org/10.1055/s-0039-1685512DOI Listing
April 2019
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The widespread increase in inter-individual variability of gene expression in the human brain with age.

Aging (Albany NY) 2019 Apr 19. Epub 2019 Apr 19.

European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, CB10 1SD, UK.

Aging is broadly defined as a time-dependent progressive decline in the functional and physiological integrity of organisms. Previous studies and evolutionary theories of aging suggest that aging is not a programmed process but reflects dynamic stochastic events. In this study, we test whether transcriptional noise shows an increase with age, which would be expected from stochastic theories. Read More

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http://dx.doi.org/10.18632/aging.101912DOI Listing
April 2019
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Does austerity really kill?

Econ Hum Biol 2019 Mar 4;33:211-223. Epub 2019 Mar 4.

Centre for Health Economics, University of York, York, United Kingdom; Luxembourg Institute for Socio-Economic Research, Esch-sur-Alzette/Belval, Luxembourg.

A growing body of the literature has argued that austerity has been bad for health, though without directly measuring austerity. This paper explicitly distinguishes the association of mortality with macroeconomic fluctuations from that with fiscal policy measures, using data for 28 European Union (EU) countries covering the period 1991-2013. The main results present a nuanced, complex picture about the mortality impact of fiscal policies. Read More

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http://dx.doi.org/10.1016/j.ehb.2019.03.002DOI Listing