4,097 results match your criteria European journal of cell biology[Journal]


Stage-specific testes proteomics of Drosophila melanogaster identifies essential proteins for male fertility.

Eur J Cell Biol 2019 Jan 17. Epub 2019 Jan 17.

Philipps-Universität Marburg, Fachbereich Biologie, Entwicklungsbiologie, Karl-von-Frisch Str. 8, 35043, Marburg, Germany. Electronic address:

Spermiogenesis in Drosophila melanogaster is a highly conserved process and essential for male fertility. In this haploid phase of spermatogenesis, motile sperm are assembled from round cells, and flagella and needle-shaped nuclei with highly compacted genomes are formed. As transcription takes place mainly in spermatocytes and transcripts relevant for post-meiotic sperm development are translationally repressed for days, we comparatively analysed the proteome of larval testes (only germ cell stages before meiotic divisions), testes of 1-2-day-old pupae (germ cell stages before meiotic divisions, meiotic and early spermatid stages) and adult flies (germ cell stages before meiotic divisions, meiotic and early spermatid stages, late spermatids and sperm). Read More

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http://dx.doi.org/10.1016/j.ejcb.2019.01.001DOI Listing
January 2019

Natural killer cells in sepsis: Underprivileged innate immune cells.

Authors:
Vijay Kumar

Eur J Cell Biol 2018 Dec 18. Epub 2018 Dec 18.

Children's Health Queensland Clinical Unit, School of Clinical Medicine, Faculty of Medicine, Mater Research, University of Queensland, ST Lucia, Brisbane, Queensland, 4078, Australia; School of Biomedical Sciences, Faculty of Medicine, University of Queensland, ST Lucia, Brisbane, Queensland, 4078, Australia. Electronic address:

Sepsis is a devastating health condition originating due to the dysregulated immune response in response to the severe systemic infection. The innate immune system serves as the first line of defense against invading pathogens, and the failure to clear the infection leads to the development of sepsis via generation of a proinflammatory immune response. Natural Killer (NK) cells are highly recognized potent innate immune cells that play a very important role in the generation of an antiviral and antitumor immune response. Read More

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http://dx.doi.org/10.1016/j.ejcb.2018.12.003DOI Listing
December 2018
4 Reads
3.825 Impact Factor

Roles and mechanisms of Kinesin-6 KIF20A in spindle organization during cell division.

Eur J Cell Biol 2018 Dec 16. Epub 2018 Dec 16.

Department of Cell Biology and Genetics/Center for Cell and Developmental Biology, The School of Basic Medical Sciences, Fujian Medical University, Fuzhou, Fujian 350108, China. Electronic address:

Mitotic kinesin is crucial for spindle assembly and chromosome segregation in cell division. KIF20A/MKlp2, a member of kinesin-6 subfamily, plays important roles in the central spindle organization at anaphase and cytokinesis. In this review, we briefly introduce the discovery and classification of kinesin-6 motors in model organisms, and summarize the biochemical features and mechanics of KIF20A proteins. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01719335183027
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http://dx.doi.org/10.1016/j.ejcb.2018.12.002DOI Listing
December 2018
13 Reads

Stem cell niche: Dynamic neighbor of stem cells.

Eur J Cell Biol 2018 Dec 12. Epub 2018 Dec 12.

Centre of Biotechnology, Nehru Science Complex, University of Allahabad, Allahabad, India. Electronic address:

Stem cell niche is a specialized and dynamic microenvironment around the stem cells which plays a critical role in maintaining the stemness properties of stem cells. Over the years, advancement in the research activity has revealed the various important aspects of stem cell niche including cell-cell interaction, cell-extracellular matrix interaction, a large number of soluble signaling factors and various biochemical and biophysical cues (such as oxygen tension, flow, and shear and pore size). Stem cells have the potential to be a powerful tool in regenerative medicine due to their self-renewal property and immense differentiation potential. Read More

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http://dx.doi.org/10.1016/j.ejcb.2018.12.001DOI Listing
December 2018
6 Reads

Overexpression of Toll-like receptor 4 enhances LPS-induced inflammatory response and inhibits Salmonella Typhimurium growth in ovine macrophages.

Eur J Cell Biol 2019 Jan 29;98(1):36-50. Epub 2018 Nov 29.

Beijing Key Laboratory for Animal Genetic Improvement, College of Animal Science and Technology, China Agricultural University, Beijing, China; National Engineering Laboratory for Animal Breeding, College of Animal Science and Technology, China Agricultural University, Beijing, China. Electronic address:

The Toll-like receptor 4 (TLR4) plays a crucial role in innate inflammatory responses, as it recognizes gram-negative bacteria (or their products) and contributes greatly to host defense against invading pathogens. Though TLR4 overexpressing transgenic sheep, resistant to certain diseases related with gram-negative bacteria, had been bred in our previous research, the effects of overexpression of TLR4 on innate immune response remained unclear. In this study, TLR4 overexpressing ovine macrophages were obtained from peripheral blood, and it was found that the overexpression of TLR4 initially promoted the production of proinflammatory cytokines TNFα and IL-6 by activating TLR4-mediated IRAK4-dependent NF-κB and MAPK (JNK and ERK1/2) signaling following LPS stimulation. Read More

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http://dx.doi.org/10.1016/j.ejcb.2018.11.004DOI Listing
January 2019
2 Reads

Adipose tissue, angiogenesis and angio-MIR under physiological and pathological conditions.

Eur J Cell Biol 2018 Nov 30. Epub 2018 Nov 30.

Department of Surgical, Oncological and Oral Sciences, Section of Plastic and Reconstructive Surgery, University of Palermo, 90127 Palermo, Italy. Electronic address:

Angiogenesis is a crucial process for the maintenance of normal tissue physiology and it is involved in tissue remodeling and regeneration. This process is essential for adipose tissue maintenance. The adipose tissue is composed by different cell types including stromal vascular cells as well as adipose stem cells (ASCs). Read More

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http://dx.doi.org/10.1016/j.ejcb.2018.11.005DOI Listing
November 2018
1 Read

Corrigendum to "Interaction of SH3P13 and DYDC1 protein: a germ cell component that regulates acrosome biogenesis during spermiogenesis" [Eur. J. Cell Biol. 88 (2009) 509-520].

Eur J Cell Biol 2019 Jan 26;98(1):51-52. Epub 2018 Nov 26.

National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Tsinghua University, 5 Dong Dan San Tiao, Beijing 100005, China.

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http://dx.doi.org/10.1016/j.ejcb.2018.11.002DOI Listing
January 2019
14 Reads
3.825 Impact Factor

A novel overlapping NLS/NES region within the PH domain of Rho Guanine Nucleotide Exchange Factor (RGNEF) regulates its nuclear-cytoplasmic localization.

Eur J Cell Biol 2019 Jan 19;98(1):27-35. Epub 2018 Nov 19.

Department of Clinical Neurological Sciences, Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada; Molecular Medicine Group, Robarts Research Institute, Western University, London, Ontario, Canada. Electronic address:

Rho Guanine Nucleotide Exchange Factor (RGNEF) is a 190 kDa protein implicated in both amyotrophic lateral sclerosis (ALS) and cancer. Under normal physiological conditions, RGNEF is predominantly cytoplasmic with moderate levels of nuclear localization. We have identified a 23-amino acid region containing a bipartite nuclear localization signal (NLS) within the Pleckstrin Homology (PH) domain of RGNEF, which when deleted or mutated abolishes the nuclear localization of this protein. Read More

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http://dx.doi.org/10.1016/j.ejcb.2018.11.001DOI Listing
January 2019
5 Reads
3.825 Impact Factor

Cell polarization: From epithelial cells to odontoblasts.

Eur J Cell Biol 2019 Jan 17;98(1):1-11. Epub 2018 Nov 17.

Department of Biomedical Sciences, Texas A&M University College of Dentistry, Dallas, TX, 75246, USA. Electronic address:

Cell polarity identifies the asymmetry of a cell. Various types of cells, including odontoblasts and epithelial cells, polarize to fulfil their destined functions. Odontoblast polarization is a prerequisite and fundamental step for tooth development and tubular dentin formation. Read More

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http://dx.doi.org/10.1016/j.ejcb.2018.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338482PMC
January 2019
1 Read
3.825 Impact Factor

WDR20 regulates shuttling of the USP12 deubiquitinase complex between the plasma membrane, cytoplasm and nucleus.

Eur J Cell Biol 2019 Jan 3;98(1):12-26. Epub 2018 Nov 3.

Department of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country (UPV/EHU), Leioa 48940, Spain. Electronic address:

The human deubiquitinases USP12 and USP46 are very closely related paralogs with critical functions as tumor suppressors. The catalytic activity of these enzymes is regulated by two cofactors: UAF1 and WDR20. USP12 and USP46 show nearly 90% amino acid sequence identity and share some cellular activities, but have also evolved non-overlapping functions. Read More

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http://dx.doi.org/10.1016/j.ejcb.2018.10.003DOI Listing
January 2019
9 Reads

Combined strategy of siRNA and osteoclast actin cytoskeleton automated imaging to identify novel regulators of bone resorption shows a non-mitotic function for anillin.

Eur J Cell Biol 2018 Nov 31;97(8):568-579. Epub 2018 Oct 31.

CRBM, Montpellier University, CNRS, France. Electronic address:

Osteoclasts are the main cells responsible for the resorption of mineralized extracellular matrices. They are the major targets for anti-resorptive therapies to manage osteoporosis, a major public health problem. Osteoclasts are giant multinucleated cells that can organize their a unique adhesion structure based on a belt of podosomes, which is the keystone of the bone resorption apparatus. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01719335183015
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http://dx.doi.org/10.1016/j.ejcb.2018.10.002DOI Listing
November 2018
6 Reads

Autophagy-lysosomal defect in human CADASIL vascular smooth muscle cells.

Eur J Cell Biol 2018 Nov 22;97(8):557-567. Epub 2018 Oct 22.

Division of Neurogeriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Huddinge, Sweden. Electronic address:

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a familial progressive degenerative disorder and is caused by mutations in NOTCH3 gene. Previous study reported that mutant NOTCH3 is more prone to form aggregates than wild-type NOTCH3 and the mutant aggregates are resistant to degradation. We hypothesized that aggregation or accumulation of NOTCH3 could be due to impaired lysosomal-autophagy machinery in VSMC. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01719335183008
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http://dx.doi.org/10.1016/j.ejcb.2018.10.001DOI Listing
November 2018
21 Reads

Anti-osteoclastic effects of C-glucosidic ellagitannins mediated by actin perturbation.

Eur J Cell Biol 2018 Nov 24;97(8):533-545. Epub 2018 Sep 24.

Centre de Recherche Cardio-Thoracique de Bordeaux (INSERM U1045), Université de Bordeaux, F-33076, Bordeaux Cedex, France. Electronic address:

Actin subunits assemble into actin filaments whose dynamics and three-dimensional architectures are further regulated by a variety of cellular factors to establish the functional actin cytoskeleton. The C-glucosidic ellagitannin vescalagin and its simpler analogue vescalin, affect both the dynamics and the ultrastructure of the actin cytoskeleton by directly binding to F-actin. Herein, we show that in vitro, the two compounds induce the formation of distinct F-actin networks characterized by different superstructures and dynamics. Read More

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http://dx.doi.org/10.1016/j.ejcb.2018.09.003DOI Listing
November 2018
3 Reads

Redox cell signaling and hepatic progenitor cells.

Eur J Cell Biol 2018 Nov 25;97(8):546-556. Epub 2018 Sep 25.

Centre for Experimental and Regenerative Medicine, Institute of Internal Medicine, Department of Medical and Surgical Sciences, University of Foggia, Italy. Electronic address:

Hepatic diseases are widespread in the world and organ transplantation is currently the only treatment for liver failure. New cell-based approaches have been considered, since stem cells may represent a possible source to treat liver diseases. Acute and chronic liver diseases are characterized by high production of reactive oxygen and nitrogen species, with consequent oxidative modifications of cellular macromolecules and alteration of signaling pathways, metabolism and cell cycle. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01719335183010
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http://dx.doi.org/10.1016/j.ejcb.2018.09.004DOI Listing
November 2018
2 Reads

ATG16 mediates the autophagic degradation of the 19S proteasomal subunits PSMD1 and PSMD2.

Eur J Cell Biol 2018 Nov 17;97(8):523-532. Epub 2018 Sep 17.

Center for Biochemistry, Medical Faculty, University of Cologne, Joseph-Stelzmann-Str. 52, 50931 Cologne, Germany.. Electronic address:

Autophagy and the ubiquitin proteasome system are the two major cellular processes for protein and organelle recycling and clearance in eukaryotic cells. Evidence is accumulating that these two pathways are interrelated through adaptor proteins. Here, we found that PSMD1 and PSMD2, both components of the 19S regulatory particle of the proteasome, directly interact with Dictyostelium discoideum autophagy 16 (ATG16), a core autophagosomal protein. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01719335183007
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http://dx.doi.org/10.1016/j.ejcb.2018.09.002DOI Listing
November 2018
3 Reads

Notch signaling regulates cell density-dependent apoptosis of NIH 3T3 through an IL-6/STAT3 dependent mechanism.

Eur J Cell Biol 2018 Sep 12;97(7):512-522. Epub 2018 Sep 12.

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, United States.

Apoptosis is a physiological process that plays a critical maintenance role in cellular homeostasis. Previous reports have demonstrated that cells undergo apoptosis in a cell density-dependent manner, which is regulated, in part, by signal transducers and activators of transcription (STAT) 3. The molecular mechanisms regulating cell density-dependent apoptosis, however, has not been thoroughly investigated to date. Read More

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http://dx.doi.org/10.1016/j.ejcb.2018.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234060PMC
September 2018
1 Read

Investigating nucleo-cytoplasmic shuttling of the human DEAD-box helicase DDX3.

Eur J Cell Biol 2018 Sep 4;97(7):501-511. Epub 2018 Aug 4.

Institute of Immunology, Biology Department, Maynooth University, Maynooth, Co. Kildare, Ireland. Electronic address:

The human DEAD-box helicase DDX3 is a multi-functional protein involved in the regulation of gene expression and additional non-conventional roles as signalling adaptor molecule that are independent of its enzymatic RNA remodeling activity. It is a nucleo-cytoplasmic shuttling protein and it has previously been suggested that dysregulation of its subcellular localization could contribute to tumourigenesis. Indeed, both tumour suppressor and oncogenic functions have been attributed to DDX3. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01719335183006
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http://dx.doi.org/10.1016/j.ejcb.2018.08.001DOI Listing
September 2018
5 Reads

Cortisol regulates immune and metabolic processes in murine adipocytes and macrophages through HTR2c and HTR5a serotonin receptors.

Eur J Cell Biol 2018 Sep 27;97(7):483-492. Epub 2018 Jul 27.

School of Biological Sciences, National Institute of Science Education and Research (NISER), HBNI, PO- Bhimpur-Padanpur, Jatni, Khurda, Odisha, 752050, India. Electronic address:

Epidemiological studies implicate stress as an important factor contributing to the increasing prevalence of metabolic disorders. Studies have correlated visceral obesity and atherosclerosis with hyper-cortisolemia, a sequela of chronic psychological stress in humans and animals. Although several hormonal markers of stress have been associated with various metabolic disorders, the mechanism by which these hormones alter metabolic functions have not been established. Read More

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http://dx.doi.org/10.1016/j.ejcb.2018.07.004DOI Listing
September 2018
4 Reads

EndMT: A promising and controversial field.

Eur J Cell Biol 2018 Sep 29;97(7):493-500. Epub 2018 Jul 29.

Department of Vascular Surgery, The Second Affiliated Hospital of Soochow University, Sanxiang Road, Suzhou 215000, JiangSu, China. Electronic address:

The endothelial to mesenchymal transition (EndMT) is the process by which endothelial cells lose a portion of their cellular features and obtain certain characteristics of mesenchymal cells, including loss of tight junctions, increased motility, and increased secretion of extracellular matrix proteins. EndMT is involved in cardiac development and a variety of diseases processes, such as vascular or tissue fibrosis and tumor. However, its role in specific diseases remains under debate. Read More

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http://dx.doi.org/10.1016/j.ejcb.2018.07.005DOI Listing
September 2018
21 Reads

Function and regulation of mitofusin 2 in cardiovascular physiology and pathology.

Eur J Cell Biol 2018 Sep 18;97(7):474-482. Epub 2018 Jul 18.

Institute for Translation Medicine, Medical College, Qingdao University, Dengzhou Road 38, Qingdao 266021, China. Electronic address:

Mitochondrial dynamics with constant fusion and fission plays vital roles in regulating cellular biological processes. Mitofusin 2 (Mfn2) is dynamin-related protein whose activity promotes mitochondrial fusion and maintains the homeostasis of mitochondrial dynamics. Advanced studies have demonstrated that Mfn2 is a multifunctional protein with signaling roles beyond fusion. Read More

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http://dx.doi.org/10.1016/j.ejcb.2018.07.003DOI Listing
September 2018
3 Reads

The transcription factor C/EBP α controls the role of cystatin F during the differentiation of monocytes to macrophages.

Eur J Cell Biol 2018 Sep 17;97(7):463-473. Epub 2018 Jul 17.

Department of Biotechnology, Jožef Stefan Institute, Jamova 39, SI-1000 Ljubljana, Slovenia; Faculty of Pharmacy, University of Ljubljana, Aškerčeva 7, SI-1000 Ljubljana, Slovenia. Electronic address:

Cystatin F is an inhibitor of cysteine peptidases expressed solely in immune cells. It is the only type II cystatin able to enter endosomal/lysosomal vesicles and to regulate directly the activity of intracellular cysteine cathepsins. Its expression in promonocytic U937 and promyeloblastic HL-60 cells is highly upregulated but, after differentiation with phorbol 12-myristate 13-acetate - PMA, its levels drop significantly. Read More

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http://dx.doi.org/10.1016/j.ejcb.2018.07.002DOI Listing
September 2018
3 Reads

Heterocellular molecular contacts in the mammalian stem cell niche.

Eur J Cell Biol 2018 Aug 7;97(6):442-461. Epub 2018 Jul 7.

Ultrastructural Pathology Laboratory, 'Victor Babeș' National Institute of Pathology, Bucharest, Romania; Department of Cellular & Molecular Biology and Histology, School of Medicine, 'Carol Davila' University of Medicine and Pharmacy, Bucharest, Romania. Electronic address:

Adult tissue homeostasis and repair relies on prompt and appropriate intervention by tissue-specific adult stem cells (SCs). SCs have the ability to self-renew; upon appropriate stimulation, they proliferate and give rise to specialized cells. An array of environmental signals is important for maintenance of the SC pool and SC survival, behavior, and fate. Read More

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http://dx.doi.org/10.1016/j.ejcb.2018.07.001DOI Listing
August 2018
6 Reads

A comprehensive review of signal peptides: Structure, roles, and applications.

Eur J Cell Biol 2018 Aug 22;97(6):422-441. Epub 2018 Jun 22.

Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; Department of Pharmaceutical Biotechnology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran; Department of Medical Biotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran; Biotechnology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address:

Signal peptides (SP) are short peptides located in the N-terminal of proteins, carrying information for protein secretion. They are ubiquitous to all prokaryotes and eukaryotes. SPs have been of special interest in several scientific and industrial fields, including recombinant protein production, disease diagnosis, immunization, and laboratory techniques. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01719335183001
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http://dx.doi.org/10.1016/j.ejcb.2018.06.003DOI Listing
August 2018
6 Reads

Participation of membrane calcium channels in erythropoietin-induced endothelial cell migration.

Eur J Cell Biol 2018 Aug 19;97(6):411-421. Epub 2018 Jun 19.

Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto del Departamento de Química Biológica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN), Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Buenos Aires, Argentina. Electronic address:

Calcium (Ca) plays an important role in angiogenesis, as it activates the cell migration machinery. Different proangiogenic factors have been demonstrated to induce transient Ca increases in endothelial cells. This has raised interest in the contribution of Ca channels to cell migration, and in a possible use of channel-blocking compounds in angiogenesis-related pathologies. Read More

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http://dx.doi.org/10.1016/j.ejcb.2018.06.002DOI Listing
August 2018
8 Reads

Extracellular pH and lung infections in cystic fibrosis.

Eur J Cell Biol 2018 Aug 18;97(6):402-410. Epub 2018 Jun 18.

Laboratory of Cellular and Molecular Biology, Institute for Biomedical Research (BIOMED UCA-CONICET), The National Scientific and Technical Research Council (CONICET), and School of Medical Sciences, The Pontifical Catholic University of Argentina (UCA), Buenos Aires, Argentina. Electronic address:

Cystic fibrosis (CF) is an autosomal recessive disease caused by CFTR mutations. It is characterized by high NaCl concentration in sweat and the production of a thick and sticky mucus, occluding secretory ducts, intestine and airways, accompanied by chronic inflammation and infections of the lungs. This causes a progressive and lethal decline in lung function. Read More

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http://dx.doi.org/10.1016/j.ejcb.2018.06.001DOI Listing
August 2018
20 Reads

RhoD localization and function is dependent on its GTP/GDP-bound state and unique N-terminal motif.

Eur J Cell Biol 2018 Aug 16;97(6):393-401. Epub 2018 May 16.

Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, SE-171 77 Stockholm, Sweden. Electronic address:

The atypical Rho GTPase RhoD has previously been shown to have a major impact on the organization and function of the actin filament system. However, when first discovered, RhoD was found to regulate endosome trafficking and dynamics and we therefore sought to investigate this regulation in more detail. We found that exogenously expressed RhoD in human fibroblasts localized to vesicles and the plasma membrane and that the active GTP-bound conformation was required for the plasma membrane localization but not for vesicle localization. Read More

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http://dx.doi.org/10.1016/j.ejcb.2018.05.003DOI Listing
August 2018
1 Read

T cells and their immunometabolism: A novel way to understanding sepsis immunopathogenesis and future therapeutics.

Authors:
V Kumar

Eur J Cell Biol 2018 Aug 5;97(6):379-392. Epub 2018 May 5.

Children's Health Queensland Clinical Unit, School of Clinical Medicine, Mater Research, Faculty of Medicine, University of Queensland, St. Lucia, Brisbane, Queensland 4078, Australia; School of Biomedical Sciences, Faculty of Medicine, University of Queensland, St. Lucia, Brisbane, Queensland 4078, Australia. Electronic address:

Sepsis has always been considered as a big challenge for pharmaceutical companies in terms of discovering and designing new therapeutics. The pathogenesis of sepsis involves aberrant activation of innate immune cells (i.e. Read More

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http://dx.doi.org/10.1016/j.ejcb.2018.05.001DOI Listing
August 2018
3 Reads

LncRNA OIP5-AS1 regulates radioresistance by targeting DYRK1A through miR-369-3p in colorectal cancer cells.

Eur J Cell Biol 2018 Jun 14;97(5):369-378. Epub 2018 Apr 14.

Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China. Electronic address:

Object: This study aimed to investigate the role of lncRNA OIP5-AS1 in regulating radioresistance of colorectal cancer (CRC) cells.

Methods: Microarray analysis was used to screen out lncRNAs differentially expressed in radio-resistant CRC cell lines. Expression levels of OIP5-AS1, miR-369-3p and DYRK1A in CRC cell lines were measured by qRT-PCR. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01719335173030
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http://dx.doi.org/10.1016/j.ejcb.2018.04.005DOI Listing
June 2018
19 Reads

The unknown face of IRE1α - Beyond ER stress.

Eur J Cell Biol 2018 Jun 4;97(5):359-368. Epub 2018 May 4.

Apoptosis and Cell Survival Research Lab, Department of Biosciences, School of Biosciences and Technology, VIT University, Vellore, Tamil Nadu, India. Electronic address:

IRE1α (Inositol Requiring kinase Enzyme 1 alpha), a transmembrane protein localized to the endoplasmic reticulum (ER) is a master regulator of the unfolded protein response (UPR) pathway. The fate determining steps during ER stress-induced apoptosis are greatly attributed to IRE1α's endoribonuclease and kinase activities. Apart from its role as a chief executioner in ER stress, recent studies have shown that upon activation in the presence or absence of ER stress, IRE1α executes multiple cellular processes such as differentiation, immune response, progression and repression of the cell cycle. Read More

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http://dx.doi.org/10.1016/j.ejcb.2018.05.002DOI Listing
June 2018
8 Reads

Anchor negatively regulates BMP signalling to control Drosophila wing development.

Eur J Cell Biol 2018 May 25;97(4):308-317. Epub 2018 Apr 25.

College of Life Sciences, Northeast Forestry University, Harbin 150040, China. Electronic address:

G protein-coupled receptors play particularly important roles in many organisms. The novel Drosophila gene anchor is an orthologue of vertebrate GPR155. However, the roles of anchor in molecular functions and biological processes, especially in wing development, remain unknown. Read More

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http://dx.doi.org/10.1016/j.ejcb.2018.04.007DOI Listing
May 2018
6 Reads

Phosphorylation of Wat1, human Lst8 homolog is critical for the regulation of TORC2 -Gad8 dependent pathway in fission yeast Schizosacchromyces pombe.

Eur J Cell Biol 2018 May 20;97(4):300-307. Epub 2018 Apr 20.

Molecular and Structural Biology Division, CSIR- Central Drug Research Institute, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow, 226031, India. Electronic address:

Mammalian Lst8 interacts with the kinase domain of mTOR and stabilizes its interaction with Raptor regulating cell growth through the mTOR-S6K1 signalling pathway. Fission yeast Wat1, an ortholog of mammalian Lst8 is also an essential component of TOR complex 1 (TORC1) and TOR Complex 2 (TORC2) that control protein kinases essential for metabolic pathways. Here, we show that in response to osmotic stress, the Wat1 protein undergoes hyper-phosphorylation at S116 position. Read More

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http://dx.doi.org/10.1016/j.ejcb.2018.04.006DOI Listing
May 2018
3 Reads

Dissecting the signaling features of the multi-protein complex GPCR/β-arrestin/ERK1/2.

Eur J Cell Biol 2018 Jun 4;97(5):349-358. Epub 2018 Apr 4.

Instituto de Fisiología Celular (UNAM), México City, 04510, Mexico. Electronic address:

G protein-coupled receptors (GPCRs) have emerged as key biological entities that regulate a plethora of physiological processes and participate in the onset and development of many diseases. Moreover, these receptors are important targets of almost 25% of the current therapeutic drugs in the market. Upon agonist binding, GPCRs activate a great number of signaling pathways, resulting in important cellular events like gene transcription, survival, proliferation and differentiation. Read More

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http://dx.doi.org/10.1016/j.ejcb.2018.04.001DOI Listing
June 2018
4 Reads

Organelle survival in a foreign organism: Hydra nematocysts in the flatworm Microstomum lineare.

Authors:
Georg Krohne

Eur J Cell Biol 2018 May 8;97(4):289-299. Epub 2018 Apr 8.

Division of Electron Microscopy, Biocenter, University of Würzburg, Am Hubland, 97074 Würzburg, Germany. Electronic address:

Nematocysts are characteristic organelles of the phylum cnidaria. They are designated kleptocnidae when sequestered in animals that feed on cnidaria. Kleptocnidae are known for more than a century. Read More

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http://dx.doi.org/10.1016/j.ejcb.2018.04.002DOI Listing
May 2018
4 Reads

Long noncoding RNA VIM-AS1 promotes colorectal cancer progression and metastasis by inducing EMT.

Eur J Cell Biol 2018 May 7;97(4):279-288. Epub 2018 Apr 7.

Department of Biotechnology, Institute of Science and High Technology and Environmental Sciences, Graduate University of Advanced Technology, Kerman, Iran.

Emerging evidence indicates that lncRNAs play crucial roles in the initiation and progression of various malignant tumors. VIM-AS1 RNA is an lncRNA that transcribes from a shared bidirectional promoter with vimentin mRNA and its function in cancer cells is largely unknown. This study assessed the clinical significance of VIM-AS1 expression in colorectal cancer (CRC). Read More

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http://dx.doi.org/10.1016/j.ejcb.2018.04.004DOI Listing
May 2018
7 Reads

Neuropeptide Y mitigates ER stress-induced neuronal cell death by activating the PI3K-XBP1 pathway.

Eur J Cell Biol 2018 Jun 6;97(5):339-348. Epub 2018 Apr 6.

Metabolism & Neurophysiology Research Group, BioNanotechnology Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 305-806, Republic of Korea; Department of Functional Genomics, University of Science and Technology (UST), Daejeon 305-600, Republic of Korea. Electronic address:

The unfolded protein response (UPR) is an evolutionarily conserved adaptive reaction that increases cell survival under endoplasmic reticulum (ER) stress conditions. ER stress-associated neuronal cell death pathways play roles in the pathogenesis of neurodegenerative diseases, including Alzheimer's, Parkinson's, and Huntington's disease. Neuropeptide Y (NPY) has an important role in neuroprotection against neurodegenerative diseases. Read More

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http://dx.doi.org/10.1016/j.ejcb.2018.04.003DOI Listing
June 2018
3 Reads
3.830 Impact Factor

Nanoscale domain formation of phosphatidylinositol 4-phosphate in the plasma and vacuolar membranes of living yeast cells.

Eur J Cell Biol 2018 May 27;97(4):269-278. Epub 2018 Mar 27.

Department of Molecular and Cell Biology and Biochemistry, Basic Veterinary Science, Faculty of Veterinary Medicine, Kagoshima University, Korimoto 1-21-24, Kagoshima, 890-0065, Japan. Electronic address:

In budding yeast Saccharomyces cerevisiae, PtdIns(4)P serves as an essential signalling molecule in the Golgi complex, endosomal system, and plasma membrane, where it is involved in the control of multiple cellular functions via direct interactions with PtdIns(4)P-binding proteins. To analyse the distribution of PtdIns(4)P in yeast cells at a nanoscale level, we employed an electron microscopy technique that specifically labels PtdIns(4)P on the freeze-fracture replica of the yeast membrane. This method minimizes the possibility of artificial perturbation, because molecules in the membrane are physically immobilised in situ. Read More

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http://dx.doi.org/10.1016/j.ejcb.2018.03.007DOI Listing
May 2018
6 Reads

Emerging Roles of DHHC-mediated Protein S-palmitoylation in Physiological and Pathophysiological Context.

Eur J Cell Biol 2018 Jun 22;97(5):319-338. Epub 2018 Mar 22.

Discipline of Biosciences and Biomedical Engineering, Indian Institute of Technology Indore, Simrol, Madhya Pradesh 453 552, India. Electronic address:

Protein S-palmitoylation refers to a post-translational modification (PTM) wherein palmitic acid, a 16-carbon long saturated fatty acid gets covalently attached to Cys sidechain of a protein. It has been known to the literature for almost 50 years and in general, this PTM is believed to facilitate membrane attachments of proteins for the obvious hydrophobicity of the palmitoyl group. But after the discovery of the protein palmitoyl acyltransferases (PATs, also known as DHHC-PATs), a major paradigm shift has been observed in the field of protein S-palmitoylation. Read More

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http://dx.doi.org/10.1016/j.ejcb.2018.03.005DOI Listing
June 2018
4 Reads

miR-22 regulates C2C12 myoblast proliferation and differentiation by targeting TGFBR1.

Eur J Cell Biol 2018 May 21;97(4):257-268. Epub 2018 Mar 21.

Institute of Swine Science, Nanjing Agricultural University, Nanjing, 210095, China. Electronic address:

Recently, miR-22 was found to be differentially expressed in different skeletal muscle growth period, indicated that it might have function in skeletal muscle myogenesis. In this study, we found that the expression of miR-22 was the most in skeletal muscle and was gradually up-regulated during mouse myoblast cell (C2C12 myoblast cell line) differentiation. Overexpression of miR-22 repressed C2C12 myoblast proliferation and promoted myoblast differentiation into myotubes, whereas inhibition of miR-22 showed the opposite results. Read More

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http://dx.doi.org/10.1016/j.ejcb.2018.03.006DOI Listing
May 2018
6 Reads

Morphogenetic movements affect local tissue organisation during embryonic Drosophila morphogenesis.

Eur J Cell Biol 2018 May 15;97(4):243-256. Epub 2018 Mar 15.

Institut de Biologia Molecular de Barcelona, CSIC, Parc Científic de Barcelona, Baldiri Reixac, 10-12, 08028 Barcelona, Spain. Electronic address:

Tissues and organs undergo extensive remodelling to reach their final morphology and physiological activity. The genetic programs underlying tissue formation are well studied, but less is known about how this formation is influenced by extrinsic forces derived from other concomitant morphogenetic events. Here we address this question in Drosophila melanogaster. Read More

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http://dx.doi.org/10.1016/j.ejcb.2018.03.004DOI Listing
May 2018
3 Reads

Exploring the multifaceted roles of heat shock protein B8 (HSPB8) in diseases.

Eur J Cell Biol 2018 Apr 13;97(3):216-229. Epub 2018 Mar 13.

Department of Neurology, 2nd Xiangya Hospital, Central South University, China. Electronic address:

HSPB8 is a member of ubiquitous small heat shock protein (sHSP) family, whose expression is induced in response to a wide variety of unfavorable physiological and environmental conditions. Investigation of HSPB8 structure indicated that HSPB8 belongs to the group of so-called intrinsically disordered proteins and possesses a highly flexible structure. Unlike most other sHSPs, HSPB8 tends to form small-molecular-mass oligomers and exhibits substrate-dependent chaperone activity. Read More

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http://dx.doi.org/10.1016/j.ejcb.2018.03.003DOI Listing
April 2018
4 Reads

GAEC1 mutations and copy number aberration is associated with biological aggressiveness of colorectal cancer.

Eur J Cell Biol 2018 Apr 13;97(3):230-241. Epub 2018 Mar 13.

Cancer Molecular Pathology, School of Medicine and Griffith Health Institute, Griffith University, Gold Coast, Queensland, 4222, Australia. Electronic address:

GAEC1 (gene amplified in oesophageal cancer 1) is a transforming oncogene with tumorigenic potential observed in both oesophageal squamous cell carcinoma and colorectal cancer. Nonetheless, there has been a lack of study done on this gene to understand how this gene exert its oncogenic properties in cancer. This study aims to identify novel mutation sites in GAEC1. Read More

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http://dx.doi.org/10.1016/j.ejcb.2018.03.002DOI Listing
April 2018
16 Reads

Insulin downregulates C3 gene expression in human HepG2 cells through activation of PPARγ.

Eur J Cell Biol 2018 Apr 9;97(3):204-215. Epub 2018 Mar 9.

Department of Biochemistry, Institute of Experimental Medicine, St. Petersburg, Russia; Department of Embryology, St. Petersburg State University, St. Petersburg, Russia. Electronic address:

C3 is an acute phase protein, and thus its plasma concentration increases quickly and drastically during the onset of inflammation. Insulin plays a complex role in inflammation. Elevated level of plasma C3 was shown to correlate with heightened fasting insulin levels and insulin resistance and appears to be a risk factor for the cardiovascular disease and atherosclerosis. Read More

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http://dx.doi.org/10.1016/j.ejcb.2018.03.001DOI Listing
April 2018
6 Reads

Glycosylation controls sodium-calcium exchanger 3 sub-cellular localization during cell cycle.

Eur J Cell Biol 2018 Apr 28;97(3):190-203. Epub 2018 Feb 28.

Department of Oncology-Pathology, Karolinska Institutet, CCK R8:05, Karolinska University Hospital Solna, SE-171 76 Stockholm, Sweden. Electronic address:

The Na/Ca exchanger (NCX) is a membrane antiporter that has been identified in the plasma membrane, the inner membrane of the nuclear envelope and in the membrane of the endoplasmic reticulum (ER). In humans, three genes have been identified, encoding unique NCX proteins. Although extensively studied, the NCX's sub-cellular localization and mechanisms regulating the activity of different subtypes are still ambiguous. Read More

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http://dx.doi.org/10.1016/j.ejcb.2018.02.004DOI Listing
April 2018
22 Reads
3.830 Impact Factor

LncRNA MIAT facilitated BM-MSCs differentiation into endothelial cells and restored erectile dysfunction via targeting miR-200a in a rat model of erectile dysfunction.

Eur J Cell Biol 2018 Apr 7;97(3):180-189. Epub 2018 Feb 7.

Health Science and Technology (Beijing) Co., Ltd., Boao Yiheshanzhuang, Beijing 102209, PR China.

Background: Bone-marrow derived mesenchymal stem cells (BM-MSCs) implantation effectively restored rats' erectile dysfunction (ED). Long noncoding RNA (LncRNA)-myocardial infarction-associated transcript (MIAT) has been reported to play an important role in regulating endothelial cells (ECs) function via vascular endothelial growth factor (VEGF) that induced BM-MSCs differentiation into ECs. However, the molecular functions and biological roles of lncRNA MIAT in ED remained unclear. Read More

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http://dx.doi.org/10.1016/j.ejcb.2018.02.001DOI Listing
April 2018
9 Reads
3.830 Impact Factor

A heterogeneous tRNA granule structure exhibiting rapid, bi-directional neuritic transport.

Eur J Cell Biol 2018 Apr 16;97(3):168-179. Epub 2018 Feb 16.

The Scripps Research Institute, Dept. of Molecular Medicine, 10550 N. Torrey Pines Rd., La Jolla, CA 92037, United States. Electronic address:

mRNA translation is regulated by diverse mechanisms that converge at the initiation and elongation steps to determine the rate, profile, and localization of proteins synthesized. A consistently relevant feature of these mechanisms is the spatial re-distribution of translation machinery, a process of particular importance in neural cells. This process has, however, been largely overlooked with respect to its potential role in regulating the local concentration of cytoplasmic tRNAs, even as a multitude of data suggest that spatial regulation of the tRNA pool may help explain the remarkably high rates of peptide elongation. Read More

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http://dx.doi.org/10.1016/j.ejcb.2018.02.002DOI Listing
April 2018
20 Reads

YBX1 at the crossroads of non-coding transcriptome, exosomal, and cytoplasmic granular signaling.

Eur J Cell Biol 2018 Apr 19;97(3):163-167. Epub 2018 Feb 19.

Department of Biochemistry and Molecular Biology, Central University of Kerala, Kasargod, Kerala, India. Electronic address:

YBX1 (Y box binding protein 1) is an RNA-/DNA-binding multifunctional protein harboring the classical cold shock protein (CSD) domain, an A/P domain, and a long C-terminal domain with alternating positively and negatively charged amino acids. It is a well-established oncogenic transcriptional factor, and regulates apoptosis, translation, cell proliferation, mRNA splicing, repair, differentiation, and stress response. The non-coding transcriptome has added yet another layer of complexity to the YBX1-mediated master regulation of cellular functions. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01719335173031
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http://dx.doi.org/10.1016/j.ejcb.2018.02.003DOI Listing
April 2018
9 Reads

trans-Golgi network-bound cargo traffic.

Eur J Cell Biol 2018 Apr 2;97(3):137-149. Epub 2018 Feb 2.

Department of Biology, Missouri State University, 901 S National Ave., Springfield, MO 65807, USA. Electronic address:

Cargo following the retrograde trafficking are sorted at endosomes to be targeted the trans-Golgi network (TGN), a central receiving organelle. Though molecular requirements and their interaction networks have been somewhat established, the complete understanding of the intricate nature of their action mechanisms in every step of the retrograde traffic pathway remains unachieved. This review focuses on elucidating known functions of key regulators, including scission factors at the endosome and tethering/fusion mediators at the receiving dock, TGN, as well as a diverse range of cargo. Read More

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http://dx.doi.org/10.1016/j.ejcb.2018.01.003DOI Listing
April 2018
4 Reads

Overexpression of the lamina proteins Lamin and Kugelkern induces specific ultrastructural alterations in the morphology of the nuclear envelope of intestinal stem cells and enterocytes.

Eur J Cell Biol 2018 Mar 31;97(2):102-113. Epub 2018 Jan 31.

Institute for Developmental Biochemistry, University of Göttingen, Justus-von-Liebig Weg 11, 37077, Göttingen, Germany. Electronic address:

The nuclear envelope has a stereotypic morphology consisting of a flat double layer of the inner and outer nuclear membrane, with interspersed nuclear pores. Underlying and tightly linked to the inner nuclear membrane is the nuclear lamina, a proteinous layer of intermediate filament proteins and associated proteins. Physiological, experimental or pathological alterations in the constitution of the lamina lead to changes in nuclear morphology, such as blebs and lobulations. Read More

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http://dx.doi.org/10.1016/j.ejcb.2018.01.002DOI Listing
March 2018
4 Reads

Melanopsin and rhodopsin mediate UVA-induced immediate pigment darkening: Unravelling the photosensitive system of the skin.

Eur J Cell Biol 2018 Apr 1;97(3):150-162. Epub 2018 Feb 1.

Laboratory of Comparative Physiology of Pigmentation, Department of Physiology, Institute of Biosciences, University of São Paulo, São Paulo, Brazil; Department of Biology, University of Virginia, Charlottesville, VA, USA. Electronic address:

The mammalian skin has a photosensitive system comprised by several opsins, including rhodopsin (OPN2) and melanopsin (OPN4). Recently, our group showed that UVA (4.4 kJ/m) leads to immediate pigment darkening (IPD) in murine normal and malignant melanocytes. Read More

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http://dx.doi.org/10.1016/j.ejcb.2018.01.004DOI Listing
April 2018
7 Reads

Insufficient Apaf-1 expression in early stages of neural differentiation of human embryonic stem cells might protect them from apoptosis.

Eur J Cell Biol 2018 Mar 1;97(2):126-135. Epub 2018 Feb 1.

Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran; Department of Developmental Biology, University of Science and Culture, Tehran, Iran. Electronic address:

Recent evidence suggests that mitochondrial apoptosis regulators and executioners may regulate differentiation, without being involved in cell death. However, the involved factors and their roles in differentiation and apoptosis are still not fully determined. In the present study, we compared mitochondrial pathway of cell death during early neural differentiation from human embryonic stem cells (hESCs). Read More

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http://dx.doi.org/10.1016/j.ejcb.2018.01.005DOI Listing
March 2018
8 Reads