292,285 results match your criteria European journal of cell biology[Journal]


Piezoelectric barium titanate nanostimulators for the treatment of glioblastoma multiforme.

J Colloid Interface Sci 2018 Dec 4;538:449-461. Epub 2018 Dec 4.

Istituto Italiano di Tecnologia, Smart Bio-Interfaces, Viale Rinaldo Piaggio 34, 56025 Pontedera, Italy; Politecnico di Torino, Department of Mechanical and Aerospace Engineering, Corso Duca degli Abruzzi 24, 10129 Torino, Italy. Electronic address:

Major obstacles to the successful treatment of gliolastoma multiforme are mostly related to the acquired resistance to chemotherapy drugs and, after surgery, to the cancer recurrence in correspondence of residual microscopic foci. As innovative anticancer approach, low-intensity electric stimulation represents a physical treatment able to reduce multidrug resistance of cancer and to induce remarkable anti-proliferative effects by interfering with Ca and K homeostasis and by affecting the organization of the mitotic spindles. However, to preserve healthy cells, it is utterly important to direct the electric stimuli only to malignant cells. Read More

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December 2018

Linking organochlorine contaminants with demographic parameters in free-ranging common bottlenose dolphins from the northern Adriatic Sea.

Sci Total Environ 2018 Dec 4;657:200-212. Epub 2018 Dec 4.

Morigenos - Slovenian Marine Mammal Society, Kidričevo nabrežje 4, 6330 Piran, Slovenia.

Marine top predators, including marine mammals, are known to bio-accumulate persistent pollutants such as polychlorinated biphenyls (PCBs), a serious conservation concern for these species. Although PCBs declined in European seas since the 1970s-1980s ban, considerable levels still persist in European and Mediterranean waters. In cetaceans, stranded animals are a valuable source of samples for pollutant studies, but may introduce both known and unknown biases. Read More

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December 2018

Molecular Evolution of Early-Onset Prostate Cancer Identifies Molecular Risk Markers and Clinical Trajectories.

Cancer Cell 2018 Dec;34(6):996-1011.e8

Finsen Laboratory, Rigshospitalet, DK-2200, Copenhagen, Denmark; Biotech Research & Innovation Centre (BRIC), University of Copenhagen, DK-2200, Copenhagen, Denmark; European Molecular Biology Laboratory (EMBL), Genome Biology Unit, 69120 Heidelberg, Germany; Charité Universitätsmedizin Berlin, Charitéplatz 1, D-10117 Berlin, Germany. Electronic address:

Identifying the earliest somatic changes in prostate cancer can give important insights into tumor evolution and aids in stratifying high- from low-risk disease. We integrated whole genome, transcriptome and methylome analysis of early-onset prostate cancers (diagnosis ≤55 years). Characterization across 292 prostate cancer genomes revealed age-related genomic alterations and a clock-like enzymatic-driven mutational process contributing to the earliest mutations in prostate cancer patients. Read More

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December 2018

Hyperactivation of Nrf2 increases stress tolerance at the cost of aging acceleration due to metabolic deregulation.

Aging Cell 2018 Dec 10:e12845. Epub 2018 Dec 10.

Department of Cell Biology and Biophysics, Faculty of Biology, National & Kapodistrian University of Athens, Athens, Greece.

Metazoans viability depends on their ability to regulate metabolic processes and also to respond to harmful challenges by mounting anti-stress responses; these adaptations were fundamental forces during evolution. Central to anti-stress responses are a number of short-lived transcription factors that by functioning as stress sensors mobilize genomic responses aiming to eliminate stressors. We show here that increased expression of nuclear factor erythroid 2-related factor (Nrf2) in Drosophila activated cytoprotective modules and enhanced stress tolerance. Read More

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December 2018

Guidelines for reporting of statistics for clinical research in urology.

BJU Int 2018 Dec 8. Epub 2018 Dec 8.

Memorial Sloan Kettering Cancer Center.

In an effort to improve the quality of statistics in the clinical urology literature, statisticians at European Urology, The Journal of Urology, Urology and BJUI came together to develop a set of guidelines to address common errors of statistical analysis, reporting and interpretation. Authors should "break any of the guidelines if it makes scientific sense to do so" but would need to provide a clear justification. Adoption of the guidelines will in our view not only increase the quality of published papers in our journals but improve statistical knowledge in our field in general. Read More

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December 2018
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Erythrocyte sedimentation rate as an independent prognostic marker for mortality: a prospective population-based cohort study.

J Intern Med 2018 Dec 9. Epub 2018 Dec 9.

Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.

Background: A very high erythrocyte sedimentation rate (ESR) is usually an indication of underlying pathology. Additionally, a moderately elevated ESR may also be attributable to biological ageing. Whether the ESR is a prognostic factor for mortality, regardless of age, has been scarcely investigated. Read More

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December 2018

Long-Term Consequences of the Chernobyl Radioactive Fallout: An Exploration of the Aggregate Data.

Milbank Q 2018 Dec;96(4):814-857

University of Padua.

Policy Points Policymakers should invest more on researching the long-term health effects of low-ionizing radiation exposure, as we are far from reaching a consensus on a topic that is of enormous importance for public health and safety. Public policies such as those limiting the import of contaminated food from areas hit by a radioactive disaster or those regulating the resident population's access to such areas should follow a precautionary approach. Neoplasm diagnosis and medical care should be designed in order to take into account the possible role of long-term, low-dose radiation exposure. Read More

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December 2018
2 Reads

Utility and implications of exome sequencing in early-onset Parkinson's disease.

Mov Disord 2018 Dec 10. Epub 2018 Dec 10.

Institute of Neurogenetics, University of Lübeck, Lübeck, Germany.

Background: Although the genetic load is high in early-onset Parkinson's disease, thorough investigation of the genetic diagnostic yield has yet to be established. The objectives of this study were to assess variants in known genes for PD and other movement disorders and to find new candidates in 50 patients with early-onset PD.

Methods: We searched for variants either within genes listed by the International Parkinson and Movement Disorder Society Task Force on Genetic Nomenclature or rare homozygous variants in novel candidate genes. Read More

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December 2018

Validation of the Acetabulum As a Skeletal Indicator of Age at Death in Modern European-Americans.

J Forensic Sci 2018 Dec 10. Epub 2018 Dec 10.

Department of Anthropology, University of West Florida, 11000 University Parkway, Bldg. 13, Pensacola, FL, 32514.

Progressive changes in the acetabulum have been used in modern skeletal age estimation, but they have not been completely understood. If their age correlations are weakened by the influence of factors like physical activity and obesity, acetabular changes should not be used for age estimation. To investigate their utility for aging, the acetabular variables of Rissech et al. Read More

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December 2018

How Representative are the Patients Included in the CV outcome Trials with SGLT2 Inhibitors of a General Type 2 Diabetes Population? A Large European Observational study.

Diabetes Obes Metab 2018 Dec 9. Epub 2018 Dec 9.

University Medical Center Groningen and Bethesda Diabetes Research Center, The Netherlands.

Aims: Enrollment criteria vary substantially between the cardiovascular outcome trials (CVOTs) of sodium-glucose cotransporter-2 inhibitors (SGLT-2is), impacting how representative a trial population is to the general type 2 diabetes (T2D) population. The aim was to evaluate the representativeness of four SGLT-2i CVOTs to a general T2D population.

Methods: T2D patients were included from Germany, the Netherlands, Norway, and Sweden. Read More

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December 2018

Its all about connections: hubs and invasion in habitat networks.

Ecol Lett 2018 Dec 9. Epub 2018 Dec 9.

Université Côte d'Azur, INRA, CNRS, ISA, 06900, Sophia Antipolis, France.

During the early stages of invasion, the interaction between the features of the invaded landscape, notably its spatial structure, and the internal dynamics of an introduced population has a crucial impact on establishment and spread. By approximating introduction areas as networks of patches linked by dispersal, we characterised their spatial structure with specific metrics and tested their impact on two essential steps of the invasion process: establishment and spread. By combining simulations with experimental introductions of Trichogramma chilonis (Hymenoptera: Trichogrammatidae) in artificial laboratory microcosms, we demonstrated that spread was hindered by clusters and accelerated by hubs but was also affected by small-population mechanisms prevalent for invasions, such as Allee effects. Read More

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December 2018

The effects of presentation time on preference for curvature of real objects and meaningless novel patterns.

Br J Psychol 2018 Dec 7. Epub 2018 Dec 7.

Human Evolution and Cognition Group (EvoCog), University of the Balearic Islands and IFISC, Associated Unit to CSIC, Palma de Mallorca, Spain.

Objects with curved contours are generally preferred to sharp-angled ones. In this study, we aim to determine whether different presentation times influence this preference. We used images of real objects (experiment 1) and meaningless novel patterns (experiment 2). Read More

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December 2018

Critical Considerations on the Clinical Translation of Upconversion Nanoparticles (UCNPs): Recommendations from the European Upconversion Network (COST Action CM1403).

Adv Healthc Mater 2018 Dec 10:e1801233. Epub 2018 Dec 10.

Institute of Analytical Chemistry, Chemo- and Biosensors, University of Regensburg, 93040, Regensburg, Germany.

The unique photoluminescent properties of upconversion nanoparticles (UCNPs) have attracted worldwide research interest and inspired many bioanalytical applications. The anti-Stokes emission with long luminescence lifetimes, narrow and multiple absorption and emission bands, and excellent photostability enable background-free and multiplexed detection in deep tissues. So far, however, in vitro and in vivo applications of UCNPs are restricted to the laboratory use due to safety concerns. Read More

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December 2018

Optimizing ex situ genetic resource collections for European livestock conservation.

J Anim Breed Genet 2018 Dec 11. Epub 2018 Dec 11.

Global Academy of Agriculture and Food Security, The University of Edinburgh, Midlothian, Edinburgh, UK.

Ex situ collections offer the potential to reduce extinction risks, affording option to society in maintaining future breeding opportunities for productivity and heritage traits. However, how much should we be seeking to collect and conserve in gene banks, and where? We developed a mathematical model to optimize logistical decisions of breed conservation choices and to evaluate alternative scenarios for efficiently re-allocating genetic materials currently stored in different European gene banks, allowing for cross-country collections, cost and cryogenic capacity differentials. We show how alternative allocations for the breeds that are currently stored in 11 European gene banks could reduce overall conservation costs by around 20% by selecting cryogenic banks that have relatively lower combination of fixed and collection costs, and are geographically closer to collection regions. Read More

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December 2018

Remote monitoring of implantable cardioverter defibrillators: Patient experiences and preferences for follow-up.

Pacing Clin Electrophysiol 2018 Dec 10. Epub 2018 Dec 10.

Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands.

Background: Patient satisfaction with remote patient monitoring (RPM) of implantable cardioverter defibrillators (ICDs) seems to be high, yet knowledge on long-term patient experiences is limited. The European REMOTE-CIED study explored patient experiences with RPM, examined patient preferences for ICD follow-up, and identified determinants of patient preferences in the first two years post-implantation.

Methods: European heart failure patients (N = 300; median age = 66 years (IQR = 59-73), and 22% female) with a first-time ICD received a Boston Scientific LATITUDE® RPM system and had scheduled in-clinic follow-ups once a year. Read More

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December 2018

Bismuth Ferrite Second Harmonic Nanoparticles for Pulmonary Macrophage Tracking.

Small 2018 Dec 10:e1803776. Epub 2018 Dec 10.

Translational Molecular Imaging, Max-Planck Institute for Experimental Medicine, Hermann-Rein-Str. 3, 37075, Göttingen, Germany.

Recently, second harmonic generation (SHG) nanomaterials have been generated that are efficiently employed in the classical (NIR) and extended (NIR-II) near infrared windows using a multiphoton microscope. The aim was to test bismuth ferrite harmonic nanoparticles (BFO-HNPs) for their ability to monitor pulmonary macrophages in mice. BFO-loaded MH-S macrophages are given intratracheally to healthy mice or BFO-HNPs are intranasally instilled in mice with allergic airway inflammation and lung sections of up to 100 μM are prepared. Read More

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December 2018
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Assessment of within-breath impulse oscillometry parameters in children with asthma.

Pediatr Pulmonol 2018 Dec 10. Epub 2018 Dec 10.

Department of Pediatrics, Severance Hospital, Institute of Allergy, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea.

Background: Impulse oscillometry (IOS) measures respiratory resistance and reactance during tidal breaths and is a convenient tool for evaluation of lung function. Respiratory resistance and reactance can be measured separately during inspiration and expiration (inspiratory-expiratory analysis).

Objective: We investigated the differences in inspiratory-expiratory measurements obtained using IOS between children with and without asthma. Read More

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December 2018

Promoting Electrocatalysis upon Aerogels.

Adv Mater 2018 Dec 9:e1804881. Epub 2018 Dec 9.

Physikalische Chemie, Technische Universität Dresden, Bergstraße 66b, 01062, Dresden, Germany.

Electrocatalysis plays a prominent role in renewable energy conversion and storage, enabling a number of sustainable processes for future technologies. There are generally three strategies to improve the efficiency (or activity) of the electrocatalysts: i) increasing the intrinsic activity of the catalyst itself, ii) improving the exposure of active sites, and iii) accelerating mass transfer during catalysis (both reactants and products). These strategies are not mutually exclusive and can ideally be addressed simultaneously, leading to the largest improvements in activity. Read More

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December 2018

Global wheat production with 1.5 and 2.0°C above pre-industrial warming.

Glob Chang Biol 2018 Dec 7. Epub 2018 Dec 7.

Agricultural & Biological Engineering Department, University of Florida, Gainesville, FL 32611, USA.

Efforts to limit global warming to below 2°C in relation to the pre-industrial level are under way, in accordance with the 2015 Paris Agreement. However, most impact research on agriculture to date has focused on impacts of warming >2°C on mean crop yields, and many previous studies did not focus sufficiently on extreme events and yield interannual variability. Here, with the latest climate scenarios from the Half a degree Additional warming, Prognosis and Projected Impacts (HAPPI) project, we evaluated the impacts of the 2015 Paris Agreement range of global warming (1. Read More

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December 2018
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The role of Eomes in human CD4 T cell differentiation: A question of context.

Eur J Immunol 2018 Dec 7. Epub 2018 Dec 7.

CIRI, Centre International de Recherche en Infectiologie - International Center for Infectiology Research, Inserm, U1111, Ecole Normale Supérieure de Lyon, Université Lyon 1, CNRS, UMR5308, Lyon, France.

Eomesodermin (Eomes) is a transcription factor (TF) of the T-box family closely related to T-bet known for its role in CD8 T cell and natural killer cell differentiation. However, the role of Eomes in CD4 T-cell differentiation is less well appreciated. In this issue of the European Journal of Immunology [Eur. Read More

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December 2018
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Understanding the importance of low-molecular weight (ethylene oxide- and propylene oxide-induced) DNA adducts and mutations in risk assessment: Insights from 15 years of research and collaborative discussions.

Environ Mol Mutagen 2018 Dec 10. Epub 2018 Dec 10.

University of North Carolina, Chapel Hill, North Carolina, USA.

The interpretation and significance of DNA adduct data, their causal relationship to mutations, and their role in risk assessment have been debated for many years. An extended effort to identify key questions and collect relevant data to address them was focused on the ubiquitous low MW N7-alkyl/hydroxyalkylguanine adducts. Several academic, governmental, and industrial laboratories collaborated to gather new data aimed at better understanding the role and potential impact of these adducts in quantifiable genotoxic events (gene mutations/micronucleus). Read More

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December 2018

Immunoglobulins and virus antibody titers: of past needs, current requirements, and future options.

Transfusion 2018 Dec;58 Suppl 3:3090-3095

Global Pathogen Safety, Shire (previously Baxter BioScience, Baxalta), Vienna, Austria.

Background: Immunoglobulins (Igs) have been in clinical use for almost 70 years, and early on were also used in conjunction with exposure to the measles virus or polio virus. The US regulations that describe functional Ig lot release thus require the demonstration of minimum antibody titers against these two viruses, although the use of vaccines has now dramatically reduced their incidence. The lower clinical importance of these viruses raises the question of whether other virus antibodies might be more informative for patients with immunodeficiency. Read More

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December 2018

The American Headache Society Position Statement On Integrating New Migraine Treatments Into Clinical Practice.

Authors:

Headache 2018 Dec 10. Epub 2018 Dec 10.

Objective: To provide healthcare professionals with updated guidance in the use of novel preventive and acute treatments for migraine in adults.

Background: The principles of preventive and acute pharmacotherapy for patients with migraine have been outlined previously, but the emergence of new technologies and treatments, as well as new formulations of previously established treatments, has created a need for an updated guidance on the preventive and acute treatment of migraine.

Methods: This statement is based on a review of existing guidelines and principles for preventive and acute treatment of migraine, as well as the results of recent clinical trials of drugs and devices for these indications. Read More

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December 2018

Incidence of severe critical events in paediatric anaesthesia in the United Kingdom: secondary analysis of the anaesthesia practice in children observational trial (APRICOT study).

Anaesthesia 2018 Dec 10. Epub 2018 Dec 10.

Department of Paediatric Anaesthesia and Pain Management, University of Glasgow, Glasgow, Scotland, UK.

The anaesthesia practice in children observational trial of 31,127 patients in 261 European hospitals revealed a high (5.2%) incidence of severe critical events in the peri-operative period and wide variability in practice. A sub-analysis of the UK data was undertaken to investigate differences compared with the non-UK cohort in the incidence and nature of peri-operative severe critical events and to attempt to identify areas for quality improvement. Read More

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December 2018

CONFINE-MAS: a magic-angle spinning NMR probe that confines the sample in case of a rotor explosion.

J Biomol NMR 2018 Dec 10. Epub 2018 Dec 10.

Physical Chemistry, ETH Zürich, Vladimir-Prelog-Weg 2, 8093, Zürich, Switzerland.

Magic-angle spinning (MAS) is mandatory in solid-state NMR experiments to achieve resolved spectra. In rare cases, instabilities in the rotation or damage of either the rotor or the rotor cap can lead to a so called "rotor crash" involving a disintegration of the sample container and possibly the release of an aerosol or of dust. We present a modified design of a 3. Read More

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December 2018

Safe adoption of robotic colorectal surgery using structured training: early Irish experience.

J Robot Surg 2018 Dec 10. Epub 2018 Dec 10.

Beacon Hospital, Beacon Court, Sandyford, Dublin 18, Republic of Ireland.

Robotic surgery enhances the precision of minimally invasive surgery through improved three-dimensional views and articulated instruments. There has been increasing interest in adopting this technology to colorectal surgery and this has recently been introduced to the Irish health system. This paper gives an account of our early institutional experience with adoption of robotic colorectal surgery using structured training. Read More

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December 2018

Impact of Long-Course Neoadjuvant Radiation on Postoperative Low Anterior Resection Syndrome and Quality of Life in Rectal Cancer: Post Hoc Analysis of a Randomized Controlled Trial.

Ann Surg Oncol 2018 Dec 7. Epub 2018 Dec 7.

Department of Colorectal Surgery, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.

Background: Neoadjuvant radiation is recommended for locally advanced rectal cancer, with proven benefit in local control but not in disease-free survival. However, the impact of long-course radiation on postoperative bowel function and quality of life (QOL) remains controversial. This study aimed to investigate the impact of long-course neoadjuvant radiation on bowel function and QOL, and to identify risk factors for severe bowel dysfunction. Read More

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December 2018

HIF-1α-derived cell-penetrating peptides inhibit ERK-dependent activation of HIF-1 and trigger apoptosis of cancer cells under hypoxia.

Cell Mol Life Sci 2018 Dec 10. Epub 2018 Dec 10.

Laboratory of Biochemistry, Faculty of Medicine, University of Thessaly, Biopolis, 41500, Larissa, Greece.

Hypoxia is frequently encountered in the microenvironment of solid tumors. Hypoxia-inducible factors (HIFs), the main effectors of cell response to hypoxia, promote cancer cell survival and progression. HIF-1α, the oxygen-regulated subunit of HIF-1, is often correlated with oncogenesis and represents an attractive therapeutic target. Read More

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December 2018

Studies in the Stypella vermiformis group (Auriculariales, Basidiomycota).

Antonie Van Leeuwenhoek 2018 Dec 8. Epub 2018 Dec 8.

Natural History Museum, University of Oslo, P.O. Box 1172, Blindern, 0318, Oslo, Norway.

Stypella vermiformis is a heterobasidiomycete producing minute gelatinous basidiocarps on rotten wood of conifers in the Northern Hemisphere. In the current literature, Stypella papillata, the genus type of Stypella (described from Brazil), is treated as a taxonomic synonym of S. vermiformis. Read More

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December 2018

Systematic Review: Efficacy and Safety of Accelerated Induction Regimes in Infliximab Rescue Therapy for Hospitalized Patients with Acute Severe Colitis.

Dig Dis Sci 2018 Dec 7. Epub 2018 Dec 7.

The Royal Liverpool and Broad Green University Hospitals NHS Foundation Trust, Liverpool, UK.

Background: Pharmacokinetic data suggest that standard induction dosing schedules may not be sufficient in patients with acute severe colitis (ASUC). Hence, intensified induction regimes are increasingly used in the rescue treatment of hospitalized patients with ASUC to avoid the need for colectomy although the evidence for this is uncertain.

Aim: To conduct a systematic review of short- and long-term efficacy outcomes from accelerated infliximab induction studies. Read More

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December 2018

Three-generation households and child mental health in European countries.

Soc Psychiatry Psychiatr Epidemiol 2018 Dec 8. Epub 2018 Dec 8.

Institut Universitaire de France, Université de Bordeaux, Bordeaux, France.

Purpose: To evaluate the associations between the presence of a grand parent at home that is three-generation household, with children mental health in diverse countries whether this situation is frequent or not.

Methods: Data from the School Children Mental Health in Europe cross-sectional survey in six countries (n = 4582) were used to examine the association between three-generation households and child mental health across Europe. The parent and teacher Strengths and Difficulties Questionnaire was combined to assess child mental clinical problems. Read More

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December 2018

Novel nomograms to predict recurrence and progression in primary non-muscle-invasive bladder cancer: validation of predictive efficacy in comparison with European Organization of Research and Treatment of Cancer scoring system.

World J Urol 2018 Dec 10. Epub 2018 Dec 10.

Department of Urology, Seoul National University Hospital, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, 110-744, Korea.

Purpose: To develop and validate novel nomograms to predict recurrence and progression after transurethral resection of bladder tumor (TURBT) in Korean patients with non-muscle-invasive bladder cancer (NMIBC).

Methods: We retrospectively analyzed the clinical data on 970 newly diagnosed NMIBC patients after TURBT between 2000 and 2013 in a single institution. We used multivariate Cox proportional hazard models to identify the significant predictors of recurrence and progression, which resulted in the construction of the nomograms predicting the 5-year probability of recurrence and progression. Read More

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December 2018
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Trends in sleeping difficulties among European adolescents: Are these associated with physical inactivity and excessive screen time?

Int J Public Health 2018 Dec 10. Epub 2018 Dec 10.

Department of Public Health, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.

Objectives: We examined changes in sleep-onset difficulties over time and associations with physical activity and screen time behavior among adolescents.

Methods: We used data from last four survey waves of the Health Behavior in School-Aged Children (HBSC) study (2002-2006-2010-2014). Multilevel logistic regression analyses were conducted to explore associations between regular sleeping difficulties, excessive screen time exposure and being insufficiently physically active (i. Read More

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December 2018
1 Read

Intrasubject repeatability of in vivo intervertebral motion parameters using quantitative fluoroscopy.

Eur Spine J 2018 Dec 8. Epub 2018 Dec 8.

Faculty of Science and Technology, Bournemouth University, Bournemouth, UK.

Purpose: In vivo quantification of intervertebral motion through imaging has progressed to a point where biomarkers for low back pain are emerging. This makes possible deeper study of the condition's biometrics. However, the measurement of change over time involves error. Read More

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December 2018
1 Read

Evaluation of the Reported Rates of Severe Hypersensitivity Reactions Associated with Ferric Carboxymaltose and Iron (III) Isomaltoside 1000 in Europe Based on Data from EudraVigilance and VigiBase™ between 2014 and 2017.

Drug Saf 2018 Dec 10. Epub 2018 Dec 10.

Vifor Pharma Management Ltd., Flughofstrasse 61, 8152, Glattbrugg, Switzerland.

Introduction: Hypersensitivity reactions (HSRs) are among the known adverse events of intravenous (i.v.) iron products. Read More

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December 2018

Scientific mistakes from the agri-food biotech critics.

Life Sci Soc Policy 2018 Dec 10;14(1):25. Epub 2018 Dec 10.

, Carugo, Como, Italy.

Critics of the use of advanced biotechnologies in the agri-food sector ("New Breeding Techniques", comprising CRISPR) demand a strict regulation of any such method, even more severe than rules applied to so-called "Genetically Modified Organisms" (i.e. recombinant DNA processes and products). Read More

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December 2018
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Water on hydrophobic surfaces: mechanistic modeling of polyethylene glycol-induced protein precipitation.

Bioprocess Biosyst Eng 2018 Dec 7. Epub 2018 Dec 7.

Karlsruhe Institute of Technology (KIT), Institute of Process Engineering in Life Sciences Section IV: Biomolecular Separation Engineering, 76131, Karlsruhe, Germany.

For the purification of biopharmaceutical proteins, liquid chromatography is still the gold standard. Especially with increasing product titers, drawbacks like slow volumetric throughput and high resin costs lead to an intensifying need for alternative technologies. Selective preparative protein precipitation is one promising alternative technique. Read More

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December 2018

International external quality assurance of JAK2 V617F quantification.

Ann Hematol 2018 Dec 8. Epub 2018 Dec 8.

Department of Hematology, Zealand University Hospital, Roskilde, Denmark.

External quality assurance (EQA) programs are vital to ensure high quality and standardized results in molecular diagnostics. It is important that EQA for quantitative analysis takes into account the variation in methodology. Results cannot be expected to be more accurate than limits of the technology used, and it is essential to recognize factors causing substantial outlier results. Read More

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December 2018

Screening of mosquitoes for filarioid helminths in urban areas in south western Poland-common patterns in European Setaria tundra xenomonitoring studies.

Parasitol Res 2018 Dec 8. Epub 2018 Dec 8.

Department of Influenza Research, National Influenza Center, National Institute of Public Health - National Institute of Hygiene, Chocimska 24, 00-791, Warszawa, Poland.

In recent years, numerous studies screening mosquitoes for filarioid helminths (xenomonitoring) have been performed in Europe. The entomological monitoring of filarial nematode infections in mosquitoes by molecular xenomonitoring might serve as the measure of the rate at which humans and animals expose mosquitoes to microfilariae and the rate at which animals and humans are exposed to the bites of the infected mosquitoes. We hypothesized that combining the data obtained from molecular xenomonitoring and phenological studies of mosquitoes in the urban environment would provide insights into the transmission risk of filarial diseases. Read More

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December 2018

Introgression reshapes recombination distribution in grapevine interspecific hybrids.

Theor Appl Genet 2018 Dec 8. Epub 2018 Dec 8.

SVQV UMR-A 1131, INRA, Université de Strasbourg, 68000, Colmar, France.

Key Message: In grapevine interspecific hybrids, meiotic recombination is suppressed in homeologous regions and enhanced in homologous regions of recombined chromosomes, whereas crossover rate remains unchanged when chromosome pairs are entirely homeologous. Vitis rotundifolia, an American species related to the cultivated European grapevine Vitis vinifera, has a high level of resistance to several grapevine major diseases and is consequently a valuable resource for grape breeding. However, crosses between both species most often lead to very few poorly fertile hybrids. Read More

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December 2018
1 Read

Prenatal developmental toxicity testing of petroleum substances using the zebrafish embryotoxicity test.

ALTEX 2018 Dec 7. Epub 2018 Dec 7.

Division of Toxicology, Wageningen University and Research, Wageningen, The Netherlands.

The present study evaluates the applicability of the zebrafish embryotoxicity test (ZET) to assess prenatal developmental toxicity (PDT) potency of the DMSO-extracts of 9 petroleum substances (PS), with variable polycyclic aromatic hydrocarbon (PAH) content, and 2 gas-to-liquid (GTL) products, without any PAHs but otherwise similar properties to PS. The results showed that all PS extracts induced concentration-dependent in vitro PDT, as quantified in the ZET and that this potency is associated with their 3-5 ring PAH content. In contrast and as expected, GTL products did not induce any effect at all. Read More

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December 2018

PhenoMeNal: Processing and analysis of Metabolomics data in the Cloud.

Gigascience 2018 Dec 7. Epub 2018 Dec 7.

Cheminformatics and Computational Metabolomics, Institute for Analytical Chemistry, Lessingstr. 8, 07743 Jena, Germany.

Background: Metabolomics is the comprehensive study of a multitude of small molecules to gain insight into an organism's metabolism. The research field is dynamic and expanding with applications across biomedical, biotechnological and many other applied biological domains. Its computationally-intensive nature has driven requirements for open data formats, data repositories and data analysis tools. Read More

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December 2018
2 Reads

Assessment of geometrical remodelling of the aortic arch after hybrid treatment.

Eur J Cardiothorac Surg 2018 Dec 7. Epub 2018 Dec 7.

Department of Vascular and Endovascular Surgery, Ospedale Policlinico San Martino, University of Genoa, Genoa, Italy.

Objectives: The aim of this study was to measure the morphological remodelling of the ascending aorta, aortic arch and thoracic aorta after aortic arch hybrid treatment including debranching and stent graft implantation.

Methods: Preoperative, 1-month and 1-year follow-up of computed tomography angiography scans of 22 patients were analysed to compute the lumen centreline from the aortic root to the coeliac trunk, and the following measurements were derived: the total centreline length, distance from the aortic root to the left subclavian artery, distance from the left subclavian artery to the distal landing zone. For both pre- and postoperative centrelines, the pointwise curvature was measured at the proximal and the distal landing zones. Read More

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December 2018

pyseer: a comprehensive tool for microbial pangenome-wide association studies.

Bioinformatics 2018 Dec;34(24):4310-4312

Department of Parasites and Microbes, Wellcome Sanger Institute, Hinxton, UK.

Summary: Genome-wide association studies (GWAS) in microbes have different challenges to GWAS in eukaryotes. These have been addressed by a number of different methods. pyseer brings these techniques together in one package tailored to microbial GWAS, allows greater flexibility of the input data used, and adds new methods to interpret the association results. Read More

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December 2018

Cancer mortality and predictions for 2018 in selected Australasian countries and Russia.

Ann Oncol 2018 Dec 11. Epub 2018 Dec 11.

Departments of Clinical Sciences and Community Health.

Background: Predicted cancer mortality figures and rates are useful for public health planning.

Materials And Methods: We retrieved cancer death certification data for 10 major cancer sites and total cancers from the World Health Organization (WHO) database and population data from WHO and United Nations Population Division databases. We obtained figures for Russia, Israel, Hong Kong, Japan, the Philippines, Korea, and Australia in 1970-2015. Read More

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December 2018

European consensus-based recommendations for the diagnosis and treatment of rare paediatric vasculitides - the SHARE initiative.

Rheumatology (Oxford) 2018 Dec 7. Epub 2018 Dec 7.

Department of Paediatric Rheumatology, Alder Hey Children's Hospital, Liverpool, UK.

Objectives: The European initiative Single Hub and Access point for paediatric Rheumatology in Europe (SHARE) aimed to optimize care for children with rheumatic diseases. Systemic vasculitides are very rare in children. Consequently, despite recent advances, paediatric-specific information is sparse. Read More

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December 2018

EDUCATION AND TRAINING IN EUROPE TO SUPPORT LOW-DOSE RADIATION PHYSICS AND RADIOBIOLOGY.

Radiat Prot Dosimetry 2018 Dec 11. Epub 2018 Dec 11.

Physics Department, University of Pavia, Pavia, Italy.

The success of any research programme is dependent on a continuing influx of new expertise, and continuing education to ensure the newest technologies and methods are exploited. In the past decade, a strategic approach has been used to build up the research expertise in the area of radiation protection and risk estimation. The High Level Expert Group (HLEG, www. Read More

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December 2018

PDX Finder: A portal for patient-derived tumor xenograft model discovery.

Nucleic Acids Res 2018 Dec 7. Epub 2018 Dec 7.

The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA.

Patient-derived tumor xenograft (PDX) mouse models are a versatile oncology research platform for studying tumor biology and for testing chemotherapeutic approaches tailored to genomic characteristics of individual patients' tumors. PDX models are generated and distributed by a diverse group of academic labs, multi-institution consortia and contract research organizations. The distributed nature of PDX repositories and the use of different metadata standards for describing model characteristics presents a significant challenge to identifying PDX models relevant to specific cancer research questions. Read More

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December 2018