297,487 results match your criteria European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies EUFOS : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery[Journal]


Legal and ethical implications of defining an optimum means of achieving unconsciousness in assisted dying.

Anaesthesia 2019 Feb 20. Epub 2019 Feb 20.

Nuffield Department of Anaesthetics, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.

A decision by a society to sanction assisted dying in any form should logically go hand-in-hand with defining the acceptable method(s). Assisted dying is legal in several countries and we have reviewed the methods commonly used, contrasting these with an analysis of capital punishment in the USA. We expected that, since a common humane aim is to achieve unconsciousness at the point of death, which then occurs rapidly without pain or distress, there might be a single technique being used. Read More

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http://dx.doi.org/10.1111/anae.14532DOI Listing
February 2019

International Divergence in Gene Patenting.

Annu Rev Genomics Hum Genet 2019 Feb 20. Epub 2019 Feb 20.

Centre for IT and IP Law, KU Leuven, 3000 Leuven, Belgium.

This review explores the recent divergence in international patent law relating to the patenting of genes and related subject matter. This divergence stems primarily from decisions of the highest courts in the United States and Australia on the eligibility of patent claims relating to the BRCA gene sequences. Patent offices, courts, and policy makers have struggled for many years to clearly articulate the bounds of patent claims on isolated and synthetic DNA and related products and processes, including methods for their use in genetic diagnostics. Read More

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http://dx.doi.org/10.1146/annurev-genom-083118-015112DOI Listing
February 2019

Acoustic Pattern Recognition and Courtship Songs: Insights from Insects.

Annu Rev Neurosci 2019 Feb 20. Epub 2019 Feb 20.

Princeton Neuroscience Institute , Princeton University, Princeton, New Jersey 08544, USA; email:

Across the animal kingdom, social interactions rely on sound production and perception. From simple cricket chirps to more elaborate bird songs, animals go to great lengths to communicate information critical for reproduction and survival via acoustic signals. Insects produce a wide array of songs to attract a mate, and the intended receivers must differentiate these calls from competing sounds, analyze the quality of the sender from spectrotemporal signal properties, and then determine how to react. Read More

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http://dx.doi.org/10.1146/annurev-neuro-080317-061839DOI Listing
February 2019

Stimuli-Directed Colorimetric Interconversion of Helical Polymers Accompanied by a Tunable Self-Assembly Process.

Small 2019 Feb 20:e1805413. Epub 2019 Feb 20.

Centro Singular de investigación en Química Biolóxica e Materiais Moleculares (CiQUS) and Departamento de Química Orgánica, Universidade de Santiago de Compostela, E-15782, Santiago de Compostela, Spain.

Interconversion between extended and bent structures at the pendant groups of a chiral polyene framework [poly(phenylacetylene) with (R)-(2-methoxy-2-phenylacetyl)glycine residues linked to 4-vinylanilines] allows the reversible colorimetric transformation from stretched to compressed helical cis-transoid polyenic structures through manipulation of the flexible spacer. This transformation generates either organogels (stretched helical form) or nanoparticles (compressed helical form) under the control of polar/low polar stimuli respectively and opens the way to the development of new sensors and stimuli-sensitive materials based on these concepts. Read More

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http://dx.doi.org/10.1002/smll.201805413DOI Listing
February 2019

Impact of maternal body mass index and gestational weight gain on pregnancy complications: An individual participant data meta-analysis of European, North American and Australian cohorts.

BJOG 2019 Feb 20. Epub 2019 Feb 20.

The Generation R Study Group, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.

Objective: To assess the separate and combined associations of maternal pre-pregnancy BMI and gestational weight gain with the risks of pregnancy complications and their population impact.

Design: Individual participant data meta-analysis of 39 cohorts.

Setting: Europe, North America and Oceania. Read More

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http://dx.doi.org/10.1111/1471-0528.15661DOI Listing
February 2019

Chronic electrical stimulation reduces hyperalgesia and associated spinal changes induced by peripheral nerve injury.

Neuromodulation 2019 Feb 20. Epub 2019 Feb 20.

Department of Cell Biology, Physiology and Immunology, Institute of Neurosciences, Universitat Autònoma de Barcelona, and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Bellaterra, Spain.

Objectives: We aimed to investigate if different protocols of electrical stimulation following nerve injury might improve neuropathic pain outcomes and modify associated plastic changes at the spinal cord level.

Materials And Methods: Adult rats were subjected to sciatic nerve transection and repair, and distributed in four groups: untreated (SNTR, n = 12), repeated acute electrical stimulation (rAES, 50 Hz, one hour, n = 12), chronic electrical stimulation (CES, 50 Hz, one hour, n = 12), and increasing-frequency chronic electrical stimulation (iCES, one hour, n = 12) delivered during two weeks following the lesion. The threshold of nociceptive withdrawal to mechanical stimuli was evaluated by means of a Von Frey algesimeter during three weeks postlesion. Read More

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http://dx.doi.org/10.1111/ner.12927DOI Listing
February 2019

Functional Genetic Variation in the Anti-Müllerian Hormone Pathway in Women with Polycystic Ovary Syndrome.

J Clin Endocrinol Metab 2019 Feb 20. Epub 2019 Feb 20.

Division of Endocrinology, Metabolism, and Molecular Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL.

Context: PCOS is a highly heritable, common endocrine disorder characterized by hyperandrogenism, irregular menses and polycystic ovaries. PCOS is often accompanied by elevated levels of anti-Müllerian hormone (AMH). AMH inhibits follicle maturation. Read More

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http://dx.doi.org/10.1210/jc.2018-02178DOI Listing
February 2019

Metabolomic profiling reveals correlations between spermiogram parameters and the metabolites present in human spermatozoa and seminal plasma.

PLoS One 2019 20;14(2):e0211679. Epub 2019 Feb 20.

Training Center of the European Academy of Andrology (EAA), Dermatology, Venerology and Allergology Clinic, University Hospital Leipzig, Leipzig, Germany.

In 50% of all infertility cases, the male is subfertile or infertile, however, the underlying mechanisms are often unknown. Even when assisted reproductive procedures such as in vitro fertilization and intracytoplasmic sperm injection are performed, the causes of male factor infertility frequently remain elusive. Since the overall activity of cells is closely linked to their metabolic capacity, we analyzed a panel of 180 metabolites in human sperm and seminal plasma and elucidated their associations with spermiogram parameters. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211679PLOS
February 2019

How the medium shapes the message: Printing and the rise of the arts and sciences.

PLoS One 2019 20;14(2):e0205771. Epub 2019 Feb 20.

The MIT Media Lab, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America.

Communication technologies, from printing to social media, affect our historical records by changing the way ideas are spread and recorded. Yet, finding statistical evidence of this fact has been challenging. Here we combine a common causal inference technique (instrumental variable estimation) with a dataset on nearly forty thousand biographies from Wikipedia (Pantheon 2. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0205771PLOS
February 2019

Secondary contact between diverged host lineages entails ecological speciation in a European hantavirus.

PLoS Biol 2019 Feb 20;17(2):e3000142. Epub 2019 Feb 20.

Institute of Ecology and Evolution, University of Bern, Switzerland.

The diversity of viruses probably exceeds biodiversity of eukaryotes, but little is known about the origin and emergence of novel virus species. Experimentation and disease outbreak investigations have allowed the characterization of rapid molecular virus adaptation. However, the processes leading to the establishment of functionally distinct virus taxa in nature remain obscure. Read More

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http://dx.doi.org/10.1371/journal.pbio.3000142DOI Listing
February 2019

[Levels of sex hormones, sex hormone binding globulin, antisperm antibodies and dopamine in postmanopausal women of nomadic and settled aboriginal and local caucasoid populations of the arctic territories.]

Klin Lab Diagn 2018 ;63(12):761-767

State institution YNAO «Scientific center of Arctic research», 629730, Nadym, Russia.

Positive changes in the society led to an improvement in quality and lifetime; as a result the menopause in women lengthens much longer, in light of this the relevance of studying hormonal changes increases, especially among the representatives of different groups living in the Arctic territories. The study was carried out on 138 women who included nomadic and settled aboriginal and local Caucasoid postmenopausal populations, permanently residing in the Arctic territories of Russia. The greatest difference in the studied blood indicators was shown between the local Caucasoid and aboriginal population. Read More

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http://dx.doi.org/10.18821/0869-2084-2018-63-12-761-767DOI Listing
January 2018

Controlling Chirality across Length Scales using DNA.

Small 2019 Feb 20:e1805419. Epub 2019 Feb 20.

Physics Department, TU München, Am Coulombwall 4a/II - 85748 Garching b., München, Germany.

Nano-objects with chiral properties attract growing interest due to their relevance for a wide variety of technological applications. For example, chiral nano-objects may be used in characterization platforms that involve chiral molecular recognition of proteins or in the fabrication of nanomechanical devices such as screw-gears or nanoswimmers. Spatial ordering of emitters of circularly polarized light might greatly benefit from the utilization of chiral shapes. Read More

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http://dx.doi.org/10.1002/smll.201805419DOI Listing
February 2019

A Molecular Cable Car for Transmembrane Ion Transport.

Authors:
Alberto Credi

Angew Chem Int Ed Engl 2019 Feb 20. Epub 2019 Feb 20.

CLAN-Center for light activated nanostructures, Università di Bologna and Consiglio Nazionale delle Ricerche, Via Gobetti 101, 40129, Bologna, Italy.

The controlled transport of molecular and ionic substrates across bilayer membranes is a fundamental task for the operation of living organisms. It is also a highly fascinating and demanding challenge for artificial molecular machines. The recent report of a synthetic transmembrane molecular shuttle that can transport potassium ions selectively down a gradient in a liposomal system makes a small but significant step towards this goal. Read More

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http://dx.doi.org/10.1002/anie.201814333DOI Listing
February 2019

Comment on the consensus report on the management of hyperglycaemia in Type 2 diabetes by the American Diabetes Association and the European Association for the Study of Diabetes.

Diabet Med 2019 Feb 20. Epub 2019 Feb 20.

University of Copenhagen, Denmark.

We read with interest the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) joint consensus report on the management of hyperglycaemia in Type 2 diabetes. Following publication of the report, discussions of the content among networks of behavioural and educational researchers prompted us to write this letter. This consensus report is to be commended for recommending that 'providers and health care systems should prioritize the delivery of patient-centered care. Read More

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http://dx.doi.org/10.1111/dme.13934DOI Listing
February 2019

Cryo-EM structures and functional characterization of the murine lipid scramblase TMEM16F.

Elife 2019 Feb 20;8. Epub 2019 Feb 20.

Department of Structural Biology, University of Groningen, Groningen, Netherlands.

The lipid scramblase TMEM16F initiates blood coagulation by catalyzing the exposure of phosphatidylserine in platelets. The protein is part of a family of membrane proteins, which encompasses calcium-activated channels for ions and lipids. Here, we reveal features of murine TMEM16F (mTMEM16F) that underlie its function as a lipid scramblase and an ion channel. Read More

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http://dx.doi.org/10.7554/eLife.44365DOI Listing
February 2019

Stepwise activation mechanism of the scramblase nhTMEM16 revealed by cryo-EM.

Elife 2019 Feb 20;8. Epub 2019 Feb 20.

Department of Structural Biology, University of Groningen, Groningen, Netherlands.

Scramblases catalyze the movement of lipids between both leaflets of a bilayer. Whereas the X-ray structure of the protein nhTMEM16 has previously revealed the architecture of a Ca-dependent lipid scramblase, its regulation mechanism has remained elusive. Here, we have used cryo-electron microscopy and functional assays to address this question. Read More

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http://dx.doi.org/10.7554/eLife.44364DOI Listing
February 2019

How Do Nutrition Guidelines Compare for Industry to Market Food and Beverage Products to Children? World Health Organization Nutrient Profile Standards Versus the US Children's Food and Beverage Advertising Initiative.

Child Obes 2019 Feb 20. Epub 2019 Feb 20.

3 Recipe for Success Foundation, Houston, TX.

Background: Food and beverage advertising targeting children influences their food choices, diets, and health. Experts have suggested that efforts on food marketing to children would be more effective if self-regulatory nutrition criteria were stronger. The US self-regulatory program, the Children's Food and Beverage Advertising Initiative (CFBAI), and the World Health Organization (WHO) Europe nutrient profile model use different approaches to set nutrition criteria for food marketing to children, making comparing the strength of their criteria challenging. Read More

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http://dx.doi.org/10.1089/chi.2018.0256DOI Listing
February 2019

Identifying asymptomatic patients at high-risk for stroke.

J Cardiovasc Surg (Torino) 2019 Feb 20. Epub 2019 Feb 20.

Medical Research Council Population Health Research Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK -

Background: Carotid endarterectomy and carotid artery stenting, in addition to good medical therapy, halve long-term stroke risk in asymptomatic patients with carotid artery stenosis. Since the absolute benefits following successful intervention are moderate, identification of asymptomatic patients at high-risk of future stroke could maximise the effectiveness of carotid interventions.

Aim: To summarise the evidence for high-risk features associated with increased long-term stroke risk in asymptomatic patients. Read More

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http://dx.doi.org/10.23736/S0021-9509.19.10912-3DOI Listing
February 2019

From Single Molecules to Thin Film Electronics, Nanofibers, e-Textiles and Power Cables: Bridging Length Scales with Organic Semiconductors.

Adv Mater 2019 Feb 20:e1807286. Epub 2019 Feb 20.

Fibre and Polymer Technology, KTH Royal Institute of Technology, 100 44 Stockholm, Sweden.

Organic semiconductors are the centerpiece of several vibrant research fields from single-molecule to organic electronics, and they are finding increasing use in bioelectronics and even classical polymer technology. The versatile chemistry and broad range of electronic functionalities of conjugated materials enable the bridging of length scales 15 orders of magnitude apart, ranging from a single nanometer (10 m) to the size of continents (10 m). This work provides a taste of the diverse applications that can be realized with organic semiconductors. Read More

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http://dx.doi.org/10.1002/adma.201807286DOI Listing
February 2019

Regulation of the cell cycle in early mammalian embryos and its clinical implications.

Int J Dev Biol 2019 Feb 6. Epub 2019 Feb 6.

Central European Institute of Technology, Department of Genetics and Reproduction, Veterinary Research Institute, Brno, Czech Republic.

Early embryonic development is characterized by a plethora of very complex and simultaneously operating processes, which are constantly changing cellular morphology and behaviour. After fertilization, blastomeres of the newly created embryo undergo global epigenetic changes and simultaneously initiate transcription from the zygotic genome and differentiation forming separate cell lineages. Some of these mechanisms were extensively studied during the last several decades and valuable insight was gained into how these processes are regulated at the molecular level. Read More

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http://dx.doi.org/10.1387/ijdb.180400maDOI Listing
February 2019

Efficacy, tolerability and safety of low volume bowel preparations in Inflammatory Bowel Diseases: The French multicentre CLEAN study.

J Crohns Colitis 2019 Feb 13. Epub 2019 Feb 13.

Department of Gastroenterology, University Hospital of Besançon, University Bourgogne Franche-Comté, Besançon, France.

Background: Standard high-volume polyethylene glycol (PEG) bowel preparations (PEG-4L) are recommended in inflammatory bowel disease (IBD) patients for colonoscopy. However, low-volume preparations (≤ 2 L of active volume) are often used in clinical practice. The aim of the study was to evaluate efficacy, tolerability and safety of the various bowel preparations in IBD, including low-volume preparations. Read More

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http://dx.doi.org/10.1093/ecco-jcc/jjz040DOI Listing
February 2019

Defining and listing very rare cancers of paediatric age: consensus of the Joint Action on Rare Cancers in cooperation with the European Cooperative Study Group for Pediatric Rare Tumors.

Eur J Cancer 2019 Feb 19;110:120-126. Epub 2019 Feb 19.

Department of Epidemiological Research and Molecular Medicine, Evaluative Epidemiology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Italy. Electronic address:

Although all tumours are rare in childhood, there are some particularly rare paediatric cancers which have not benefited from advances made by the international paediatric oncology network. To establish a shared definition and produce a list of these entities, the European Union Joint Action on Rare Cancers (JARC) promoted a consensus effort. The definition was based on the incidence rates estimated using the information network on rare cancers (RARECAREnet) database, pooling data from 94 population-based cancer registries and 27 countries. Read More

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http://dx.doi.org/10.1016/j.ejca.2018.12.031DOI Listing
February 2019

Chemical speciation, pollution and ecological risk of toxic metals in readily washed off road dust in a megacity (Nanjing), China.

Ecotoxicol Environ Saf 2019 Feb 20;173:381-392. Epub 2019 Feb 20.

College of Geography and Environment, Shandong Normal University, Ji'nan, PR China. Electronic address:

Pollution of potentially toxic metals (PTMs) in road dust (RD) is becoming an important threat to the urban environmental quality and human health. The chemical speciation of PTMs is an important index charactering the risks, which may also closely relate to the pollution level and source but it was poorly understood. In this study, the chemical speciation of Cd, Cr, Cu, Ni, Pb and Zn in the RD of a megacity (Nanjing), China was determined following an optimized BCR (proposed by the European Community Bureau of Reference) sequential extraction procedure to assess their pollution and potential eco-risk and to explore the variations of metal chemical speciation with the pollution levels and sources. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2019.02.019DOI Listing
February 2019

Study of antidepressant use in 5 European settings. Could economic, sociodemographic and cultural determinants be related to their use?

J Affect Disord 2019 Feb 6;249:278-285. Epub 2019 Feb 6.

Hospital Universitari Vall d'Hebron, Barcelona, Spain; Fundació Institut Català de Farmacologia, Passeig de la Vall d'Hebron, 119-129, 08035, Barcelona, Spain; Department of Clinical Pharmacology, Therapeutics and Toxicology, Universitat Autònoma de Barcelona, Bellaterra, Spain. Electronic address:

Background: We aimed at describing the trends in antidepressants use (AD) by age and sex, during 2007-2011, in 5 European settings (Sweden, Norway, Denmark, Catalonia and Veneto), and to assess whether the differences found across settings could be related to economic, social and cultural determinants.

Methods: We collected data of AD use expressed in defined daily doses (DDD). Data were retrieved from population-based databases. Read More

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http://dx.doi.org/10.1016/j.jad.2019.01.039DOI Listing
February 2019

Identifying Extrinsic versus Intrinsic Drivers of Variation in Cell Behavior in Human iPSC Lines from Healthy Donors.

Cell Rep 2019 Feb;26(8):2078-2087.e3

Centre for Stem Cells and Regenerative Medicine, King's College London, Floor 28, Tower Wing, Guy's Hospital, Great Maze Pond, London SE1 9RT, UK. Electronic address:

Large cohorts of human induced pluripotent stem cells (iPSCs) from healthy donors are a potentially powerful tool for investigating the relationship between genetic variants and cellular behavior. Here, we integrate high content imaging of cell shape, proliferation, and other phenotypes with gene expression and DNA sequence datasets from over 100 human iPSC lines. By applying a dimensionality reduction approach, Probabilistic Estimation of Expression Residuals (PEER), we extracted factors that captured the effects of intrinsic (genetic concordance between different cell lines from the same donor) and extrinsic (cell responses to different fibronectin concentrations) conditions. Read More

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http://dx.doi.org/10.1016/j.celrep.2019.01.094DOI Listing
February 2019

Cognitive deficits in problematic internet use: meta-analysis of 40 studies.

Br J Psychiatry 2019 Feb 20:1-8. Epub 2019 Feb 20.

Department of Psychiatry,University of Cambridge; andPeterborough NHS Foundation Trust,Cambridge,UK.

Background: Excessive use of the internet is increasingly recognised as a global public health concern. Individual studies have reported cognitive impairment in problematic internet use (PIU), but have suffered from various methodological limitations. Confirmation of cognitive deficits in PIU would support the neurobiological plausibility of this disorder. Read More

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http://dx.doi.org/10.1192/bjp.2019.3DOI Listing
February 2019

The minimum length of follow-up in hand surgery reports.

J Hand Surg Eur Vol 2019 Mar;44(3):330-331

The Journal of Hand Surgery (European Volume).

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http://dx.doi.org/10.1177/1753193418821101DOI Listing

Spiritual Care for Everyone? An Analysis of Personal and Organizational Differences in Perceptions of Religious Diversity among Spiritual Caregivers.

J Health Care Chaplain 2019 Feb 20:1-20. Epub 2019 Feb 20.

a Faculty of Theology , Vrije Universiteit Amsterdam , Amsterdam , The Netherlands.

In multicultural and multifaith societies spiritual caregivers increasingly meet clients with diverse (non-)religious or spiritual orientations. We investigate how this religious and spiritual (R/S) diversity is dealt with by spiritual caregivers working in healthcare settings, the military, and prisons. Based on a survey among spiritual caregivers (n = 208) in a secularized, European country (The Netherlands), this study shows how spiritual caregivers' personal as well as organizational factors relate to attitudes to R/S diversity. Read More

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http://dx.doi.org/10.1080/08854726.2018.1556549DOI Listing
February 2019

Treatment of Surface Plasmon Resonance (SPR) Background in Total Internal Reflection Ellipsometry: Characterization of RNA Polymerase II Film Formation.

Appl Spectrosc 2019 Feb 20:3702819826280. Epub 2019 Feb 20.

1 Department of Condensed Matter Physics, Masaryk University, Brno, Czech Republic.

To deal with the general problem of biomolecule specific binding analysis, we have applied the technique of difference spectra to the surface plasmon resonance (SPR)-enhanced total internal reflection ellipsometry measurement. We suggest a three-step treatment of the SPR background that can easily be integrated with the usual measurement routine. First, making use of the difference spectrum in ellipsometric angle Δ, single peak footprints of the topmost layer are obtained that facilitate its sensitive detection during film growth. Read More

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http://dx.doi.org/10.1177/0003702819826280DOI Listing
February 2019

HIV care cascade and sustainable wellbeing of people living with HIV in context.

J Int AIDS Soc 2019 Feb;22(2):e25259

Department of Social Policy, London School of Economics and Politics (LSE), London, United Kingdom.

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http://dx.doi.org/10.1002/jia2.25259DOI Listing
February 2019

Novel dye for detection of callus embryo by confocal laser scanning fluorescence microscopy.

Luminescence 2019 Feb 19. Epub 2019 Feb 19.

Department of Biotechnology, Daugavpils University, Institute of Life Sciences and Technology, Daugavpils, Latvia.

In the present study a new luminescent dye 3-N-(2-pyrrolidinylacetamido)benzanthrone (AZR) was synthesized. Spectroscopic measurements of the novel benzanthrone 3-aminoderivative were performed in seven organic solvents showing strong fluorescence. The capability of the prepared dye for visualization has been tested on flax, red clover and alfalfa to determinate the embryo in plant callus tissue cultures. Read More

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http://dx.doi.org/10.1002/bio.3616DOI Listing
February 2019

Unrestricted factor analysis of multidimensional test items based on an objectively refined target matrix.

Behav Res Methods 2019 Feb 19. Epub 2019 Feb 19.

Universitat Rovira i Virgili, Tarragona, Spain.

A common difficulty in the factor analysis of items designed to measure psychological constructs is that the factor structures obtained using exploratory factor analysis tend to be rejected if they are tested statistically with a confirmatory factor model. An alternative to confirmatory factor analysis is unrestricted factor analysis based on Procrustes rotation, which minimizes the distance from a target matrix proposed by the researcher. In the present article, we focus on the situation in which researchers propose a partially specified target matrix but are prepared to allow their initial target to be refined. Read More

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http://dx.doi.org/10.3758/s13428-019-01209-1DOI Listing
February 2019

Single-Stranded DNA Virus Sequencing (SSV-Seq) for Characterization of Residual DNA and AAV Vector Genomes.

Methods Mol Biol 2019 ;1950:85-106

INSERM UMR1089, University of Nantes, Centre Hospitalier Universitaire de Nantes, Nantes, France.

With the success of clinical trials using recombinant adeno-associated viral vectors (rAAV), regulatory agencies ask for a more comprehensive characterization of process- and product- related impurities found in rAAV stocks in order to assess the potential risks for patients. During production, rAAV capsids are known to internalize illegitimate DNA fragments in addition to their recombinant genome. These contaminants can come from plasmid or helper virus DNA as well as from the producer host cell. Read More

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http://dx.doi.org/10.1007/978-1-4939-9139-6_5DOI Listing
January 2019

Overstory-understory land cover mapping at the watershed scale: accuracy enhancement by multitemporal remote sensing analysis and LiDAR.

Environ Sci Pollut Res Int 2019 Feb 19. Epub 2019 Feb 19.

Department of Construction, Universidad de Extremadura, 10003, Cáceres, Spain.

In forested watersheds, density, land cover, and its vertical structure are crucial factors for flood management, ecosystem monitoring, and biomass inventory. Nowadays, producing land cover maps with high accuracy has become a reality with the application of remote sensing techniques, but in some situations, it is not so easy to distinguish between the overstory and understory vegetation with only spectral information. The main goal of this study was to analyze the accuracy enhancement in overstory and understory land cover mapping at the watershed scale when using the data fusion of seasonal and annual time series of Sentinel-2 images complemented with low-density LiDAR and soil and vegetation indices. Read More

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http://dx.doi.org/10.1007/s11356-019-04520-8DOI Listing
February 2019

Current mentorship practices in the training of the next generation of clinical microbiology and infectious disease specialists: an international cross-sectional survey.

Eur J Clin Microbiol Infect Dis 2019 Feb 19. Epub 2019 Feb 19.

Institute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.

The purpose of this study was to describe the current practice of mentorship in clinical microbiology (CM) and infectious diseases (ID) training, to identify possible areas for improvement and to assess the factors that are associated with satisfactory mentorship. An international cross-sectional survey containing 35 questions was answered by 317 trainees or specialists who recently completed clinical training. Overall, 179/317 (56%) trainees were satisfied with their mentors, ranging from 7/9 (78%) in non-European countries, 39/53 (74%) in Northern Europe, 13/22 (59%) in Eastern Europe, 61/110 (56%) in Western Europe, 37/76 (49%) in South-Western Europe to 22/47 (47%) in South-Eastern Europe. Read More

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http://dx.doi.org/10.1007/s10096-019-03509-yDOI Listing
February 2019

Evaluation of antiemetic practices for prevention of chemotherapy-induced nausea and vomiting (CINV): results of a European oncology nurse survey.

Support Care Cancer 2019 Feb 19. Epub 2019 Feb 19.

Nursing Research Unit, University Hospital Halle (Saale), Halle, Germany.

Introduction: Preventing CINV is possible when guideline-recommended antiemetics are used. Because oncology nurses play a critical role in risk assessment and management of CINV, a survey of European nurses was conducted to evaluate antiemetic practices, assess awareness of and adherence to current guideline recommendations, and explore barriers to adherence.

Methods: From March 2016 to Feb 2017, 212 oncology nurses in 16 European countries completed a 20-question online survey. Read More

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http://dx.doi.org/10.1007/s00520-019-04697-1DOI Listing
February 2019

Qualitative and quantitative neointimal characterization by optical coherence tomography in patients presenting with in-stent restenosis.

Clin Res Cardiol 2019 Feb 19. Epub 2019 Feb 19.

Deutsches Herzzentrum München, Klinik an der Technischen Universität München, Munich, Germany.

Aims: To describe optical coherence tomography (OCT) findings in patients with in-stent restenosis (ISR) and determine predictors of neointimal patterns and neoatherosclerosis.

Methods And Results: Patients undergoing OCT prior to PCI for ISR in three European centres were included. Analyses were performed in a core laboratory. Read More

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http://dx.doi.org/10.1007/s00392-019-01439-5DOI Listing
February 2019

A reference high-density genetic map of greater yam (Dioscorea alata L.).

Theor Appl Genet 2019 Feb 20. Epub 2019 Feb 20.

CIRAD, UMR AGAP, 97170, Petit-Bourg, Guadeloupe, France.

Key Message: This study generated the first high-density genetic map for D. alata based on genotyping-by-sequencing and provides new insight on sex determination in yam. Greater yam (Dioscorea alata L. Read More

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http://dx.doi.org/10.1007/s00122-019-03311-6DOI Listing
February 2019

Suitability of jumps as a form of high-intensity interval training: effect of rest duration on oxygen uptake, heart rate and blood lactate.

Eur J Appl Physiol 2019 Feb 19. Epub 2019 Feb 19.

Sensorimotor Performance Lab, University of Konstanz, 78457, Constance, Germany.

Purpose: High-intensity interval training (HIT) has been shown to be an effective endurance training method. However, most HIT research has been conducted on running and cycling. The aim of this study was to assess the suitability of intermittent exercises such as jumps as a type of HIT. Read More

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http://dx.doi.org/10.1007/s00421-019-04105-wDOI Listing
February 2019

Preparation of citrinin-selective molecularly imprinted polymer and its use for on-line solid-phase extraction coupled to liquid chromatography.

Anal Bioanal Chem 2019 Feb 19. Epub 2019 Feb 19.

The Department of Analytical Chemistry, Faculty of Pharmacy, Charles University, Heyrovského 1203, 500 05, Hradec Králové, Czech Republic.

A new selective molecularly imprinted polymer has been prepared and used for extraction in on-line SPE-HPLC to achieve the selective determination of citrinin. Four different imprinted polymers varying in combinations of components were prepared by bulk polymerization and evaluated in terms of binding capacity and selectivity. Imprinted polymer prepared from a mixture comprising 1-hydoxy-2-naphtoic acid as the template molecule, acrylamide as the structural monomer, ethylene dimethacrylate as the cross-linker (in a molar ratio of 1:4:16), and acetonitrile as the porogenic solvent exhibited the best properties. Read More

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http://dx.doi.org/10.1007/s00216-019-01682-9DOI Listing
February 2019

European Society of Paediatric Radiology Computed Tomography and Dose Task Force: European guidelines on diagnostic reference levels for paediatric imaging.

Pediatr Radiol 2019 Feb 19. Epub 2019 Feb 19.

Department of Radiology, Great Ormond Street Hospital for Children, NHS Foundation Trust, London, UK.

The recent European Council Directive 2013/59/EURATOM requires the establishment of diagnostic reference levels (DRLs) to optimise radiation dose in diagnostic and interventional radiology procedures. At the time this directive was enacted, just a few European countries had already set paediatric DRLs and many of these were outdated. For this reason, the European Commission launched a project addressing European Guidelines on Diagnostic Reference Levels for Paediatric Imaging that was awarded to a consortium led by the European Society of Radiology with the collaboration of the European Society of Paediatric Radiology and other European stakeholders involved in the radiation protection of children. Read More

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http://dx.doi.org/10.1007/s00247-019-04346-zDOI Listing
February 2019

The origin of L.

PeerJ 2019 13;7:e6384. Epub 2019 Feb 13.

Meise Botanic Garden, Meise, Belgium.

Background: L. is a weed with a world-wide distribution and unknown origin. Though it belongs to a section of the genus from South America, the evidence that this species came from there is weak. Read More

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http://dx.doi.org/10.7717/peerj.6384DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377598PMC
February 2019

New European Union Regulations Related to Whole Slide Image Scanners and Image Analysis Software.

J Pathol Inform 2019 24;10. Epub 2019 Jan 24.

VISILAB, Superior Engineering School, Castilla-La Mancha University, Ciudad Real, Spain.

Whole slide imaging (WSI) scanners and automatic image analysis algorithms, in order to be used for clinical applications, including primary diagnosis in pathology, are subject to specific regulatory frameworks in each country. Until May 25, 2018, in the European Union (EU), diagnostic (IVD) medical devices were regulated by directive 98/79/EC ( diagnostic medical device directive [IVDD]). Main scanner vendors have obtained a Conformité Européenne mark of their products that in Europe were classified as General Class IVDD, so that conformity is only based on a self-declaration of the manufacturer. Read More

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http://dx.doi.org/10.4103/jpi.jpi_33_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369630PMC
January 2019

Influence of sows' parity on performance and humoral immune response of the offspring.

Porcine Health Manag 2019 14;5. Epub 2019 Feb 14.

PigCHAMP Pro Europa S.L., c. Dámaso Alonso, 14, Segovia, Spain.

Background: Primiparous sows (PP) have higher nutrient requirements, fewer piglets born with lower birth weight and growth performance than multiparous sows (MP). The aim of the current study was to investigate the effect of parity of sow (PP or MP) on the growth performance and humoral immune response of piglets. A total of 10 PP and 10 MP (3rd to 5th parity) sows were used. Read More

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http://dx.doi.org/10.1186/s40813-018-0111-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375126PMC
February 2019

Optimisation of [C]-choline synthesis.

Contemp Oncol (Pozn) 2018 31;22(4):260-265. Epub 2018 Dec 31.

Department of Medical Physics, Maria Sklodowska-Curie Memorial Cancer Centre and Institute of Oncology, Gliwice Branch, Poland.

The importance of [C]-choline as a PET/CT marker has been extensively described, although its production presents considerable technical difficulties. The main ones are short half-lives and the occurrence of dimethylformamide (DMF) as a residual solvent. While the losses resulting from the radionuclide decay can be minimised by shortening the duration of the process, the best solution for reducing the content of DMF is its elimination from the reaction environment. Read More

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http://dx.doi.org/10.5114/wo.2018.81751DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377417PMC
December 2018

Rho-kinase inhibitor coupled to peptide-modified albumin carrier reduces portal pressure and increases renal perfusion in cirrhotic rats.

Sci Rep 2019 Feb 19;9(1):2256. Epub 2019 Feb 19.

Department of Internal Medicine I, University of Bonn, Bonn, Germany.

Rho-kinase (ROCK) activation in hepatic stellate cells (HSC) is a key mechanism promoting liver fibrosis and portal hypertension (PTH). Specific delivery of ROCK-inhibitor Y-27632 (Y27) to HSC targeting mannose-6-phosphate-receptors reduces portal pressure and fibrogenesis. In decompensated cirrhosis, presence of ascites is associated with reduced renal perfusion. Read More

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http://dx.doi.org/10.1038/s41598-019-38678-5DOI Listing
February 2019

Origin and expansion of the mosquito Aedes aegypti in Madeira Island (Portugal).

Sci Rep 2019 Feb 19;9(1):2241. Epub 2019 Feb 19.

Global Health and Tropical Medicine, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Lisboa, Portugal.

Historically known as the yellow fever mosquito, Aedes aegypti invaded Madeira Island in 2005 and was the vector of the island's first dengue outbreak in 2012. We have studied genetic variation at 16 microsatellites and two mitochondrial DNA genes in temporal samples of Madeira Island, in order to assess the origin of the invasion and the population structure of this mosquito vector. Our results indicated at least two independent colonization events occurred on the island, both having a South American source population. Read More

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http://dx.doi.org/10.1038/s41598-018-38373-xDOI Listing
February 2019

Mitochondrial Haplogroup and the Risk of Acute Kidney Injury Following Cardiac Bypass Surgery.

Sci Rep 2019 Feb 19;9(1):2279. Epub 2019 Feb 19.

Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, NE1 3BZ, UK.

Although mitochondrial dysfunction plays a key role in the pathophysiology of acute kidney injury (AKI), the influence of mitochondrial genetic variability in this process remains unclear. We explored the association between the risk of post-cardiac bypass AKI and mitochondrial haplotype - inherited mitochondrial genomic variations of potentially functional significance. Our single-centre study recruited consecutive patients prior to surgery. Read More

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http://dx.doi.org/10.1038/s41598-018-37944-2DOI Listing
February 2019

Attention-Deficit Hyperactivity Disorder Symptom Status in a Mixed Gender Population of Opioid-Maintained Prison Inmates.

Eur Addict Res 2019 Feb 18;25(2):80-92. Epub 2019 Feb 18.

Department for Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.

Objective: Attention-deficit hyperactivity disorder (ADHD) often coincides with substance abuse and delinquency. A sample of opioid-maintained inmates was assessed for symptoms of ADHD, substance abuse history, types of offense, psychiatric comorbidities, and psychopharmacological treatment using a standardized battery of instruments.

Method: Adult inmates (n = 133, mean age 35. Read More

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http://dx.doi.org/10.1159/000496351DOI Listing
February 2019

Lactose Intolerance: Common Misunderstandings.

Ann Nutr Metab 2018 19;73 Suppl 4:30-37. Epub 2019 Feb 19.

Department of Translational Medical Science - Pediatric Section, University of Naples "Federico II", Naples,

Lactose intolerance primarily refers to a syndrome having different symptoms upon the consumption of foods containing lactose. It is one of the most common form of food intolerance and occurs when lactase activity is reduced in the brush border of the small bowel mucosa. Individuals may be lactose intolerant to varying degrees, depending on the severity of these symptoms. Read More

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http://dx.doi.org/10.1159/000493669DOI Listing
February 2019