302,103 results match your criteria European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies EUFOS : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery[Journal]


The Degree of Multidimensional Severity of Alcohol Use Disorder among Treatment-Seeking Patients: Is There an Additive Effect of Parental Alcohol Use Disorder?

Eur Addict Res 2019 Apr 18:1-7. Epub 2019 Apr 18.

Unit for Clinical Alcohol Research, Unit for Psychiatric Research, Department of Clinical Research, University of Southern, Odense, Denmark.

Background: The additive effect of parental alcohol use disorders (AUD) is conventionally defined as an increasing risk of the offspring developing AUD relative to family history negative, < family history positive with 1 parent (FHP1), < FHP2. The few studies on the additive effect of parental AUD have focused on the risk of development of offspring AUD and not on the degree of multidimensional AUD addiction severity.

Aims: The aims of the present study were to examine the frequency of treatment-seeking outpatients exposed to FHP1 and FHP2 and whether addiction severity was impacted by the additive effect of parental AUD among AUD female and male offspring. Read More

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http://dx.doi.org/10.1159/000499935DOI Listing
April 2019
1 Read

Overview of bioremediation with technology assessment and emphasis on fungal bioremediation of oil contaminated soils.

J Environ Manage 2019 Apr 15;241:156-166. Epub 2019 Apr 15.

PROFNIT - Professional Post-Graduate Program in Intellectual Property and Technology Transfer for Innovation, Federal University of Bahia, Campus de Ondina, R. Barão de Jeremoabo, 147, Ondina, Salvador, BA, 40170-115, Brazil; José de Anchieta College, Av. João Durval Carneiro, n. 3039, São João, Feira de Santana, BA, 44051-605, Brazil. Electronic address:

Environmental contamination is a problem that requires sustainable solutions. Bioremediation technologies have been developed in the last decades and are increasingly used to mitigate environmental accidents and systematic contaminations. A review of bioremediation technologies, based on published article and patent documents, is presented for different types of contaminated matrices, bioremediation agents and contaminants. Read More

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http://dx.doi.org/10.1016/j.jenvman.2019.04.019DOI Listing

Contamination of a hospital plumbing system by persister cells of a copper-tolerant high-risk clone of Pseudomonas aeruginosa.

Water Res 2019 Apr 10;157:579-586. Epub 2019 Apr 10.

Laboratoire d'Hygiène Hospitalière, Centre Hospitalier Régional Universitaire, Besançon, France; UMR CNRS 6249, Chrono-environnement, Université de Bourgogne Franche-Comté, Besançon, France; Centre de Ressources Biologiques - Filière Microbiologique de Besançon, Centre Hospitalier Régional Universitaire, Besançon, France. Electronic address:

Background: Pseudomonas aeruginosa (PA) is an important opportunistic pathogen that thrives best in the distal elements of plumbing and waste-water systems. Although nosocomial outbreaks of PA have been associated with water sources, the role of the plumbing system of healthcare premises as a reservoir for this pathogen is still unclear.

Materials And Methods: We collected water samples from 12 technical areas, distant from any medical activity, in a teaching hospital in France once a week for 11 weeks. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00431354193031
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http://dx.doi.org/10.1016/j.watres.2019.04.011DOI Listing
April 2019
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Bioavailable Sr/Sr in European soils: A baseline for provenancing studies.

Sci Total Environ 2019 Mar 31;672:1033-1044. Epub 2019 Mar 31.

Eurogeosurveys, Brussels, Belgium.

We present Sr/Sr isotope ratios for ~1200 selected soil samples, collected by the GEMAS consortium from grazing (Gr) and agricultural (Ap) soils in Europe with the aim to better understand the strontium isotope distribution in the bioavailable fraction of the top-soil and its potential for provenancing applications. Spatial analysis shows that there is a clear distinction between coastal (<100 km) and non-coastal (>100 km) samples in their variance and that this variance is mirrored in the sodium concentration, suggesting an important but highly variable contribution from seaspray. We present two Sr/Sr maps at 25 km × 25 km scale: one based solely on the measured data using a classical kriging approach and one based on a Random Forest model using complementary GEMAS data to predict the strontium isotope composition at the remaining 3000+ GEMAS sampling locations, including appropriate uncertainty assessment. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00489697193138
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http://dx.doi.org/10.1016/j.scitotenv.2019.03.387DOI Listing
March 2019
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Identification and expression of microRNAs in european eels Anguilla anguilla from two natural sites with different pollution levels.

Environ Pollut 2019 Apr 11;250:274-283. Epub 2019 Apr 11.

Univ. Bordeaux, UMR EPOC CNRS 5805, 33615, Pessac, France.

MicroRNAs (miRNAs) are a class of small non-coding RNA that control multiple biological processes through negative post-transcriptional regulation of gene expression. Recently a role of miRNAs in the response of aquatic organisms to environmental toxicants emerged. Toxicant-induced changes in miRNA expression might then represent novel biomarkers to evaluate the health status of these organisms. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02697491183507
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http://dx.doi.org/10.1016/j.envpol.2019.04.029DOI Listing
April 2019
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Establishing treatment optimisation as part of personalised medicine development.

Eur J Cancer 2019 Apr 15;113:96-97. Epub 2019 Apr 15.

Member of the European Parliament, Brussels, Belgium.

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http://dx.doi.org/10.1016/j.ejca.2019.03.014DOI Listing

Finally an evidence-based indication for injectable phloroglucinol!

J Gynecol Obstet Hum Reprod 2019 Apr 15. Epub 2019 Apr 15.

CHU Toulouse, Pôle de Gynécologie Obstétrique, Hôpital Paule de Viguier, Toulouse, F-31059, France; Université de Toulouse III, UMR1027, Toulouse, F-31073, France. Electronic address:

Background: While phloroglucinol is widely prescribed in European countries for its antispasmodic properties, recent high quality data failed to demonstrate its superiority to placebo in alleviating abdominal pain. Rumors suggest that injectable presentation of phloroglucinol may erase povidone-iodine stains. We thus aimed to evaluate its efficacy in this new indication. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24687847193013
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http://dx.doi.org/10.1016/j.jogoh.2019.04.008DOI Listing
April 2019
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Development and pharmacokinetics of a combination vaginal ring for sustained release of dapivirine and the protein microbicide 5P12-RANTES.

Int J Pharm 2019 Apr 15. Epub 2019 Apr 15.

School of Pharmacy, Queen's University Belfast, Belfast BT9 7BL, UK. Electronic address:

The past fifteen years have witnessed a resurgence of interest in vaginal ring technologies for drug delivery applications, mostly driven by the impetus for development of vaginally-administered antiretroviral microbicides to help reduce the high acquisition rates for human immunodeficiency virus (HIV) among Sub-Saharan African women. Currently, the lead candidate microbicide is a 28-day silicone elastomer vaginal ring releasing dapivirine (Ring-004), an experimental non-nucleoside reverse transcriptase inhibitor. The ring was tested in two pivotal Phase III clinical studies in 2016 and is currently undergoing review by the European Medicines Agency. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2019.04.040DOI Listing

Reconciling the controversial data on the effects of C fullerene at the organismal and molecular levels using as a model Drosophila melanogaster.

Toxicol Lett 2019 Apr 15. Epub 2019 Apr 15.

Taras Shevchenko National University of Kyiv, Volodymyrska St., 64, 01601, Kyiv, Ukraine.

Fullerenes have attracted attention since their discovery as structural units of complex carbon nanostructures capable of transporting drugs and macromolecules. As such artificial nanomaterials are applied in biology and medicine, they are routinely scrutinized for their effects on living organisms. The results of such studies range from direct destabilizing effects on DNA molecules to amelioration of the toxic effects of known genotoxic agents. Read More

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http://dx.doi.org/10.1016/j.toxlet.2019.03.006DOI Listing

The historical development of pharmacopoeias and the inclusion of exotic herbal drugs with a focus on Europe and Brazil.

J Ethnopharmacol 2019 Apr 15:111891. Epub 2019 Apr 15.

Department of Biomedical Sciences, University of Cagliari, Via Ospedale 72, 09124, Cagliari, Italy. Electronic address:

Ethnopharmacological Relevance: In spite of the rich bio-cultural diversity found in the Neotropics relatively few herbal drugs native to South-America are included in the global pharmacopoeia.

Material And Methods: In the attempt to historically explain the inclusion of herbal drugs into official pharmacopoeias we consider the disparate epidemiology and cultural evolution of the New and the Old World. We then trace the development of pharmacopoeias and review forces that worked towards and against the synchronization of pharmacopoeias and highlight the role of early chemical and pharmacological studies in Europe. Read More

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http://dx.doi.org/10.1016/j.jep.2019.111891DOI Listing

IL-17-high asthma with features of a psoriasis immunophenotype.

J Allergy Clin Immunol 2019 Apr 15. Epub 2019 Apr 15.

Respiratory, Inflammation, Autoimmunity IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden.

Background: The role of interleukin-17 immunity is well established in inflammatory diseases like psoriasis and inflammatory bowel disease but not in asthma where further study is required.

Objective: To undertake a deep-phenotyping study of asthmatics with up-regulated interleukin-17 immunity.

Methods: Whole genome transcriptomic analysis was performed using epithelial brushings, bronchial biopsies (91 asthmatics patients and 46 healthy controls) and whole blood samples (n=498) from the U-BIOPRED cohort. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00916749193048
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http://dx.doi.org/10.1016/j.jaci.2019.03.027DOI Listing
April 2019
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Development, qualification, and validation of the Filovirus Animal Nonclinical Group anti-Ebola virus glycoprotein immunoglobulin G enzyme-linked immunosorbent assay for human serum samples.

PLoS One 2019 18;14(4):e0215457. Epub 2019 Apr 18.

Battelle, West Jefferson, OH, United States of America.

The need for an efficacious vaccine against highly pathogenic filoviruses was reinforced by the recent and devastating 2014-2016 outbreak of Ebola virus (EBOV) disease in Guinea, Sierra Leone, and Liberia that resulted in more than 10,000 casualties. Such a vaccine would need to be vetted through a U.S. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215457PLOS

Influence of cultivar, irrigation, ripening stage, and annual variability on the oxidant/antioxidant systems of olives as determined by MDS-PTA.

PLoS One 2019 18;14(4):e0215540. Epub 2019 Apr 18.

Department of Plant Biology, Ecology and Earth Sciences (Research Group FBCMP), Extremadura University, Badajoz, Spain.

The phenolic composition and content of olive fruit are some of the attributes that determine oil quality. This composition depends on the olive variety, the cultivation system, and the fruit's ripeness. This study considered two olive varieties (Manzanilla and Morisca), under two water regimes (irrigated and rainfed), harvested at three stages of maturation (S1, S2, and S3), over three consecutive campaigns (2011, 2012, and 2013). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215540PLOS

Varicose veins of lower extremities: Insights from the first large-scale genetic study.

PLoS Genet 2019 Apr 18;15(4):e1008110. Epub 2019 Apr 18.

Laboratory of Theoretical and Applied Functional Genomics, Novosibirsk State University, Novosibirsk, Russia.

Varicose veins of lower extremities (VVs) are a common multifactorial vascular disease. Genetic factors underlying VVs development remain largely unknown. Here we report the first large-scale study of VVs performed on a freely available genetic data of 408,455 European-ancestry individuals. Read More

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http://dx.doi.org/10.1371/journal.pgen.1008110DOI Listing

Selenium and Selenoprotein P Deficiency Correlates with Complications and Adverse Outcome After Major Trauma.

Shock 2019 Apr 12. Epub 2019 Apr 12.

Department of Trauma Surgery, University Hospital Munich, Ludwig-Maximilians-University, Munich, Germany.

Background: A declining selenium (Se) status constitutes a characteristic of critical illness and may affect disease course and survival. The dynamics of trauma-induced changes in biomarkers of Se status are poorly characterized, and an association with multiple organ failure (MOF) and mortality can be hypothesized. It was the aim of this study to investigate Se and selenoprotein P (SELENOP) concentrations in major trauma patients during the early posttraumatic period. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001344DOI Listing

Response: Comment on "Guideline Assessment Project: Filling the GAP in Surgical Guidelines: Quality Improvement Initiative by an International Working Group".

Ann Surg 2019 Apr 13. Epub 2019 Apr 13.

European Association for Endoscopic Surgery Consensus and Guideline Subcommittee, Eindhoven, Netherlands Department of Surgery, European University Cyprus, Nicosia, Cyprus Department of Vascular and Endovascular Surgery, The Royal Oldham Hospital, Pennine Acute Hospitals NHS Trust, Manchester, UK Division of Cardiovascular Sciences, School of Medical Sciences, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1097/SLA.0000000000003319DOI Listing

Assessment of Long-Term Structural Deterioration of Transcatheter Aortic Bioprosthetic Valves Using the New European Definition.

Circ Cardiovasc Interv 2019 Apr;12(4):e007597

Normandie Univ, UNIROUEN, INSERM U1096, Rouen University Hospital, Department of Cardiology, FHU REMOD-VHF, France (E.D., A.S., C.T., P.Y.L., G.A., A.C., H.E.).

Background: The durability of transcatheter aortic bioprosthetic valves is a crucial issue, but data are scarce, especially beyond 5 years of follow-up. We aimed to assess long-term (7 years) structural valve deterioration (SVD) and bioprosthetic valve failure of transcatheter aortic bioprosthetic valves.

Methods And Results: Consecutive patients with at least 5-year follow-up available undergoing transcatheter aortic valve implantation from April 2002 to December 2011 in 5 French centers were included. Read More

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https://www.ahajournals.org/doi/10.1161/CIRCINTERVENTIONS.11
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http://dx.doi.org/10.1161/CIRCINTERVENTIONS.118.007597DOI Listing
April 2019
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The Potential of Self-Management mHealth for Pediatric Cystic Fibrosis: Mixed-Methods Study for Health Care and App Assessment.

JMIR Mhealth Uhealth 2019 Apr 18;7(4):e13362. Epub 2019 Apr 18.

Instituto ITACA, Universitat Politècnica de València, Valencia, Spain.

Background: Remote care services and patient empowerment have boosted mobile health (mHealth). A study of user needs related to mHealth for pediatric cystic fibrosis (PCF) identified the set of preferred features mobile apps should support; however, the potential use of PCF apps and their suitability to fit into PCF clinical management remains unexplored.

Objective: We examine whether PCF holds potential for the implementation of mHealth care. Read More

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http://dx.doi.org/10.2196/13362DOI Listing

Joint EFLM-COLABIOCLI recommendation for venous blood sampling.

Ann Biol Clin (Paris) 2019 Apr;77(2):131-154

This document provides a joint recommendation for venous blood sampling of the European federation of clinical chemistry and laboratory medicine (EFLM) Working Group for preanalytical phase (WG-PRE) and Latin American working group for preanalytical phase (WG-PRE-LATAM) of the Latin America confederation of clinical biochemistry (COLABIOCLI). It offers guidance on the requirements for ensuring that blood collection is a safe and patient-centered procedure and provides practical guidance on how to successfully overcome potential barriers and obstacles to its widespread implementation. The target audience for this recommendation are healthcare staff members directly involved in blood collection. Read More

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http://dx.doi.org/10.1684/abc.2019.1419DOI Listing

[Clinical Characteristics of Patients with Ph Mixed Phenotype Acute Leukemia].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2019 Apr;27(2):354-359

Blood Diseases Hospital, Institute of Hematology, Chinese Academy of Medical Sciences, Peking Union Medical College, Tianjin 300020

Objective: To investigate the clinical biological characteristics and prognosis of the patients with mixed phenotype acute leukemia with t(9;22)(q34;q11.2) and/or BCRABL1 (Ph MPAL).

Methods: The morphological, immunological, cytogenetic, and molecular features of 33 in patients with Ph MPAL were retrospectively analyzed in our center from June 2002 to June 2016 according to the scoring proposal of European Group for the Classification of Acute Leukemia(EGIL )1998 and WHO 2008 criteria. Read More

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http://dx.doi.org/10.19746/j.cnki.issn.1009-2137.2019.02.007DOI Listing

Seeing social events: The visual specialization for dyadic human-human interactions.

J Exp Psychol Hum Percept Perform 2019 Apr 18. Epub 2019 Apr 18.

Institut des Sciences Cognitives-Marc Jeannerod.

Detection and recognition of social interactions unfolding in the surroundings is as vital as detection and recognition of faces, bodies, and animate entities in general. We have demonstrated that the visual system is particularly sensitive to a configuration with two bodies facing each other as if interacting. In four experiments using backward masking on healthy adults, we investigated the properties of this dyadic visual representation. Read More

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http://dx.doi.org/10.1037/xhp0000646DOI Listing

Model for the Prediction of the Lifetime and Energy Yield of Methyl Ammonium Lead Iodide Perovskite Solar Cells at Elevated Temperatures.

ACS Appl Mater Interfaces 2019 Apr 18. Epub 2019 Apr 18.

With the realization of highly efficient perovskite solar cells, the long-term stability of these devices is the key challenge hindering their commercialization. In this work, we study the temperature dependent stability of perovskite solar cells and develop a model capable of predicting the lifetime and energy yield of perovskite solar cells outdoors. This model results from the measurement of the kinetics governing the degradation of perovskite solar cells at elevated temperatures. Read More

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http://dx.doi.org/10.1021/acsami.9b00923DOI Listing

[Basal insulin degludec (Tresiba®)].

Rev Med Liege 2019 Apr;74(4):226-232

Département d'Endocrinologie clinique et expérimentale, UZ Gasthuisberg, KU Leuven, Belgique.

Insulin degludec (Tresiba®) is characterized by an original mode of prolonged and continuous insulin release after its subcutaneous injection. Thereby, it has a very long glucose-lowering effect, around 42 hours, and a better reproducibility from both a pharmacokinetic and pharmacodynamic point of view. Its efficacy and safety have been assessed in the phase 3 clinical programme BEGIN as compared with insulin glargine U100, in patients with type 1 diabetes (T1D) and type 2 (T2D). Read More

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Psoas and Paraspinous Muscle Measurements on Computed Tomography Predict Mortality in European Americans with Type 2 Diabetes Mellitus.

J Frailty Aging 2019 ;8(2):72-78

Barry I. Freedman, MD, Internal Medicine - Nephrology, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1053, Phone: 336-716-6461, Fax: 336-716-4318,

Background: Appendicular skeletal muscle mass index and muscle attenuation (density) are negatively associated with mortality in European-derived populations.

Objectives: The present analyses assessed association between axial skeletal muscle density and muscle index with mortality in European Americans with type 2 diabetes mellitus (T2D).

Design: Single-center observational study. Read More

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http://dx.doi.org/10.14283/jfa.2019.5DOI Listing
January 2019

Enteric nervous system in the European beaver (Castor fiber) pylorus - an immunohistochemical study.

Pol J Vet Sci 2019 Mar;22(1):101-107

Department of Animal Anatomy, Faculty of Veterinary Medicine, University of Warmia and Mazury, Oczapowskiego 13, 10-718 Olsztyn, Poland.

European beaver (Castor fiber), the largest rodent species inhabiting a wide area of Eurasia, feeds mainly on dry parts of plants, bark or wood. Such kind of nourishment needs to be properly digested in each part of the gastrointestinal tract. The time of stomach digestion, which directly influences all the following steps of the digestion process, is precisely controlled by the pylorus and its innervation. Read More

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http://journals.pan.pl/dlibra/publication/127076
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http://dx.doi.org/10.24425/pjvs.2019.127076DOI Listing
March 2019
2 Reads

Genetic variants in the liver kinase B1-AMP-activated protein kinase pathway genes and pancreatic cancer risk.

Mol Carcinog 2019 Apr 17. Epub 2019 Apr 17.

Duke Cancer Institute, Duke University Medical Center, Durham, North Carolina.

The liver kinase B1-AMP-activated protein kinase (LKB1-AMPK) pathway has been identified as a new target for cancer therapy, because it controls the glucose and lipid metabolism in response to alterations in nutrients and intracellular energy levels. In the present study, we aimed to identify genetic variants of the LKB1-AMPK pathway genes and their associations with pancreatic cancer (PanC) risk using 15 418 participants of European ancestry from two previously published PanC genome-wide association studies. We found that six novel tagging single-nucleotide polymorphisms (SNPs) (i. Read More

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http://dx.doi.org/10.1002/mc.23018DOI Listing

RW-2018-Research Workshop: The Effect of Nutrition on Epigenetic Status, Growth, and Health.

JPEN J Parenter Enteral Nutr 2019 Apr 17. Epub 2019 Apr 17.

Department of Surgery, Division of Pediatric Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.

The goal of the 2018 American Society for Parenteral and Enteral Nutrition (ASPEN) Research Workshop was to explore the influence of nutrition and dietary exposure to xenobiotics on the epigenome during critical periods in development and how these exposures influence both disease incidence and severity transgenerationally. A growing compendium of research indicates that the incidence and severity of common and costly human diseases may be influenced by dietary exposures and deficiencies that modify the epigenome. The greatest periods of vulnerability to these exposures are the periconception period and early childhood. Read More

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http://dx.doi.org/10.1002/jpen.1536DOI Listing

Health literacy of nursing students and its effective factors.

Nurs Forum 2019 Apr 17. Epub 2019 Apr 17.

Department of Nursing, Faculty of Health Sciences, Atılım University, Ankara, Turkey.

Background: The insufficiency of health literacy negatively affects the national economy as it leads to increased health service expenditure. It is very important for individuals to have accurate health-related information to reduce these negative effects.

Aim: The aim of the study is to examine the health literacy of nursing students and its effective factors. Read More

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http://dx.doi.org/10.1111/nuf.12346DOI Listing

Setting-up a Real-Time Air Quality Forecasting system for Serbia: a WRF-Chem feasibility study with different horizontal resolutions and emission inventories.

Environ Sci Pollut Res Int 2019 Apr 17. Epub 2019 Apr 17.

Faculty of Sciences, Department of Physics, University of Novi Sad, Dositej Obradovic Square 3, Novi Sad, Serbia.

In this paper, the influence of the horizontal model grid size and anthropogenic gridded emissions on the air quality forecast in Serbia was analyzed using the online-coupled Weather Research and Forecasting model with Chemistry (WRF-Chem). For that purpose, six simulations were performed. The model horizontal grid size was 20 × 20 km, 10 × 10 km, and 5 × 5 km. Read More

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http://dx.doi.org/10.1007/s11356-019-05140-yDOI Listing

The impact of vaginal dilator use on vaginal stenosis and sexual quality of life in women treated with adjuvant radiotherapy for endometrial cancer.

Strahlenther Onkol 2019 Apr 17. Epub 2019 Apr 17.

Department of Radiation Oncology, University Hospital Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany.

Background: Despite a lack of evidence and low compliance, current guidelines recommend the use of a vaginal dilator (VD) after pelvic radiotherapy (RT). We analyzed the effect of VD on vaginal stenosis (VS) and its influence on sexual quality of life (QoL) in women treated with adjuvant RT for endometrial cancer (EC).

Methods: Between 2014 and 2015, 56 consecutive patients were instructed to use a VD after completion of treatment. Read More

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http://dx.doi.org/10.1007/s00066-019-01466-1DOI Listing

Changes in plasma phospholipid fatty acid profiles over 13 years and correlates of change: European Prospective Investigation into Cancer and Nutrition-Norfolk Study.

Am J Clin Nutr 2019 Apr 17. Epub 2019 Apr 17.

MRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom.

Background: Little is known about changes in blood fatty acid compositions over time and the correlates of any changes in a general population.

Objective: The aim of this study was to estimate changes in 27 individual plasma phospholipid fatty acids and fatty acid groups over time, and to identify potential correlates of these changes.

Methods: Plasma phospholipid fatty acids were profiled at 3 time-points (1993-1997, 1998-2000, 2004-2011) among 722 participants in the European Prospective Investigation into Cancer and Nutrition-Norfolk Study, UK. Read More

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http://dx.doi.org/10.1093/ajcn/nqz030DOI Listing

Modelling and evaluation of PEM hydrogen technologies for frequency ancillary services in future multi-energy sustainable power systems.

Heliyon 2019 Apr 4;5(4):e01396. Epub 2019 Apr 4.

Department of Electrical Sustainable Energy, Delft University of Technology, Mekelweg 4, 2628 CD, Delft, the Netherlands.

This paper examines the prospect of PEM (Proton Exchange Membrane) electrolyzers and fuel cells to partake in European electrical ancillary services markets. First, the current framework of ancillary services is reviewed and discussed, emphasizing the ongoing European harmonization plans for future frequency balancing markets. Next, the technical characteristics of PEM hydrogen technologies and their potential uses within the electrical power system are discussed to evaluate their adequacy to the requirements of ancillary services markets. Read More

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http://dx.doi.org/10.1016/j.heliyon.2019.e01396DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451170PMC

Robotic lobectomy has the greatest benefit in patients with marginal pulmonary function.

J Thorac Dis 2019 Mar;11(Suppl 3):S322-S324

Division of Thoracic Surgery, European Institute of Oncology, University of Milan, Milan, Italy.

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http://dx.doi.org/10.21037/jtd.2018.12.132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424766PMC

Comparison of pulmonary metastasectomy and stereotactic body radiation therapy for the treatment of lung metastases.

J Thorac Dis 2019 Mar;11(Suppl 3):S280-S282

Department of Thoracic Surgery, IRCCS European Institute of Oncology, Milan, Italy.

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http://dx.doi.org/10.21037/jtd.2019.01.72DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424761PMC

Global, regional and national burden of emergency medical diseases using specific emergency disease indicators: analysis of the 2015 Global Burden of Disease Study.

BMJ Glob Health 2019 30;4(2):e000733. Epub 2019 Mar 30.

The Centre for Global Child Health, Hospital for Sick Children, Toronto, Ontario, Canada.

Objective: There are currently no metrics for measuring population-level burden of emergency medical diseases (EMDs). This study presents an analysis of the burden of EMDs using two metrics: the emergency disease mortality rate (EDMR) and the emergency disease burden (EDB) per 1000 population at the national, regional and global levels.

Methods: We used the 1990 and 2015 Global Burden of Disease Study for morbidity and mortality data on 249 medical conditions in 195 countries. Read More

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http://dx.doi.org/10.1136/bmjgh-2018-000733DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441258PMC

The discovery of three new hare lagoviruses reveals unexplored viral diversity in this genus.

Virus Evol 2019 Jan 9;5(1):vez005. Epub 2019 Apr 9.

Marie Bashir Institute for Infectious Diseases and Biosecurity, Charles Perkins Centre, School of Life and Environmental Sciences and Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia.

Our knowledge of mammalian viruses has been strongly skewed toward those that cause disease in humans and animals. However, recent metagenomic studies indicate that most apparently healthy organisms carry viruses, and that these seemingly benign viruses may comprise the bulk of virus diversity. The bias toward studying viruses associated with overt disease is apparent in the lagoviruses (family that infect rabbits and hares: although most attention has been directed toward the highly pathogenic members of this genus-rabbit haemorrhagic disease virus and European brown hare syndrome virus-a number of benign lagoviruses have also been identified. Read More

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https://academic.oup.com/ve/article/doi/10.1093/ve/vez005/54
Publisher Site
http://dx.doi.org/10.1093/ve/vez005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456799PMC
January 2019
1 Read

Randomised, double-blind, phase III study comparing the infliximab biosimilar, PF-06438179/GP1111, with reference infliximab: efficacy, safety and immunogenicity from week 30 to week 54.

RMD Open 2019 28;5(1):e000876. Epub 2019 Mar 28.

Metroplex Clinical Research Center, Dallas, Texas, USA.

Objective: To investigate the efficacy, safety and immunogenicity of PF-06438179/GP1111 (PF-SZ-IFX) compared with European reference infliximab (Remicade; ref-IFX) in patients with moderate-to-severe, active rheumatoid arthritis after continued long-term use of PF-SZ-IFX, and in patients who were switched from ref-IFX to PF-SZ-IFX.

Methods: REFLECTIONS B537-02 was a double-blind, active-controlled, multinational study in which patients (N=650) were initially randomised to PF-SZ-IFX or ref-IFX for 30 weeks (treatment period [TP] 1). During weeks 30-54 (TP2), the PF-SZ-IFX group (n=280) continued treatment with PF-SZ-IFX (PF-SZ-IFX/PF-SZ-IFX) and patients in the ref-IFX group (n=286) were rerandomised (1:1) to continue ref-IFX (ref-IFX/ref-IFX) (n=143) or switch to PF-SZ-IFX (ref-IFX/PF-SZ-IFX) (n=143) for a further 24 weeks. Read More

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http://dx.doi.org/10.1136/rmdopen-2018-000876DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446180PMC

MRI of skeletal muscles in patients with idiopathic inflammatory myopathies: characteristic findings and diagnostic performance in dermatomyositis.

RMD Open 2019 28;5(1):e000850. Epub 2019 Mar 28.

Division of Rheumatology, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.

Objective: To define the characteristic findings on MRI of skeletal muscles in patients with dermatomyositis (DM) relative to those in patients with other idiopathic inflammatory myopathies (IIMs) and to assess their diagnostic performance in DM.

Methods: Thirty-six patients with DM, 17 patients with amyopathic DM, 19 patients with polymyositis and 16 patients with non-IIM classified by the 2017 European League Against Rheumatism/American College of Rheumatology criteria were included in this study. The following MRI findings (short-tau inversion recovery [STIR] and gadolinium-enhanced fat-suppressed T1-weighted imaging [Gd-T1WI]) for proximal limb muscles were compared between the disease groups and between myositis-specific autoantibodies/myositis-associated autoantibodies (MSAs/MAAs)-positive and MSAs/MAAs-negative groups: structures with high signal intensity (HSI) (subcutaneous, fascia, muscle); distributions of HSI areas in muscle (diffuse, patchy, peripheral) and patterns of HSI in muscle (honeycomb, foggy, strong HSI). Read More

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http://dx.doi.org/10.1136/rmdopen-2018-000850DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443133PMC

Setting the international standard for longitudinal follow-up of patients with systemic sclerosis: a Delphi-based expert consensus on core clinical features.

RMD Open 2019 4;5(1):e000826. Epub 2019 Mar 4.

Rheumatology A Department, Universite Paris Descartes, Paris, France.

Background: Systemic sclerosis (SSc) is a severe, progressive multiorgan disease but to date, there are no established standardised international guidelines for follow-up of patients with SSc. The goal of this project was to develop an expert consensus for annual systematic investigations in patients with SSc to enhance their standard-of-care.

Material And Methods: The Delphi method was applied. Read More

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http://rmdopen.bmj.com/lookup/doi/10.1136/rmdopen-2018-00082
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http://dx.doi.org/10.1136/rmdopen-2018-000826DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446182PMC
March 2019
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Molecular multifunctionality preservation upon surface deposition for a chiral single-molecule magnet.

Chem Sci 2019 Mar 24;10(10):3065-3073. Epub 2019 Jan 24.

Department of Chemistry , University of Copenhagen , Universitetsparken 5 , DK-2100 , Copenhagen , Denmark . Email:

The synthesis and characterization of a chiral, enneanuclear Mn(iii)-based, Single-Molecule Magnet, [MnO(Me-sao)(L)(MeO)(MeOH)]Cl (; Me-saoH = methylsalicylaldoxime, HL = lipoic acid) is reported. Compound crystallizes in the orthorhombic 222 space group and consists of a metallic skeleton describing a defect super-tetrahedron missing one vertex. The chirality of the [Mn] core originates from the directional bridging of the Me-sao ligands the -N-O- oximate moieties, which define a clockwise () or counter-clockwise () rotation in both the upper [Mn] and lower [Mn] subunits. Read More

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http://dx.doi.org/10.1039/c8sc04917cDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428142PMC

Point prevalence survey of healthcare-associated infections and antimicrobial use in Kosovo hospitals.

Infect Dis Rep 2019 Feb 19;11(1):7975. Epub 2019 Mar 19.

National Institute for Infectious Diseases "Lazzaro Spallanzani"- IRCCS, Rome, Italy.

Health care-associated infections (HAIs) and antimicrobial resistance constitute a major public health challenge. The aim of this study was to assess the prevalence rate of HAIs and antimicrobial use in acute care hospitals in Kosovo. A multicenter study was performed in all hospitals in Kosovo. Read More

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http://dx.doi.org/10.4081/idr.2019.7975DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444376PMC
February 2019

Unexpected massive pleural effusion leading to discovery of left subclavian artery rupture during transcatheter aortic valve implantation.

J Cardiol Cases 2019 Apr 13;19(4):136-139. Epub 2019 Feb 13.

Department of Medicine, Teikyo University School of Medicine, Tokyo, Japan.

An 89-year-old woman underwent transcatheter aortic valve implantation (TAVI) for severe aortic valve stenosis, based on a logistic European System for Cardiac Operative Risk Evaluation of 59.6% and Society of Thoracic Surgeons risk score of 17.1%. Read More

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http://dx.doi.org/10.1016/j.jccase.2018.12.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451059PMC

[Spinal cord stimulation for non-reconstructable chronic ritical limb ischemiae: a case report].

Beijing Da Xue Xue Bao Yi Xue Ban 2019 Apr;51(2):362-364

Department of Vascular Surgery, Peking University People's Hospital, Beijing 100044, China.

Peripheral arterial disease is one part of systematic atherosclerosis, becoming a heavy burden of human health. Patients in end stage of peripheral arterial disease manifest critical limb ischemia with severe rest pain and refractory ulcer. Surgical revascularization is the optimal option for patients with critical limb ischemia to avoid major amputation and improve quality of life. Read More

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Publisher Correction: Martian dust storm impact on atmospheric HO and D/H observed by ExoMars Trace Gas Orbiter.

Nature 2019 Apr 17. Epub 2019 Apr 17.

Space Research Institute (IKI), Russian Academy of Sciences (RAS), Moscow, Russia.

The surname of author Cathy Quantin-Nataf was misspelled 'Quantin-Nata' , authors Ehouarn Millour and Roland Young were missing from the ACS Science Team list, and minor changes have been made to the author and affiliation lists; see accompanying Amendment. These errors have been corrected online. Read More

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http://dx.doi.org/10.1038/s41586-019-1163-xDOI Listing

Neurocranial development of the coelacanth and the evolution of the sarcopterygian head.

Nature 2019 Apr 17. Epub 2019 Apr 17.

UMR 7179 (MNHN-CNRS) MECADEV, Département Adaptations du Vivant, Muséum National d'Histoire Naturelle, Paris, France.

The neurocranium of sarcopterygian fishes was originally divided into an anterior (ethmosphenoid) and posterior (otoccipital) portion by an intracranial joint, and underwent major changes in its overall geometry before fusing into a single unit in lungfishes and early tetrapods. Although the pattern of these changes is well-documented, the developmental mechanisms that underpin variation in the form of the neurocranium and its associated soft tissues during the evolution of sarcopterygian fishes remain poorly understood. The coelacanth Latimeria is the only known living vertebrate that retains an intracranial joint. Read More

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http://www.nature.com/articles/s41586-019-1117-3
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http://dx.doi.org/10.1038/s41586-019-1117-3DOI Listing
April 2019
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Predicting disruptive instabilities in controlled fusion plasmas through deep learning.

Nature 2019 Apr 17. Epub 2019 Apr 17.

Princeton Plasma Physics Laboratory, Princeton, NJ, USA.

Nuclear fusion power delivered by magnetic-confinement tokamak reactors holds the promise of sustainable and clean energy. The avoidance of large-scale plasma instabilities called disruptions within these reactors is one of the most pressing challenges, because disruptions can halt power production and damage key components. Disruptions are particularly harmful for large burning-plasma systems such as the multibillion-dollar International Thermonuclear Experimental Reactor (ITER) project currently under construction, which aims to be the first reactor that produces more power from fusion than is injected to heat the plasma. Read More

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http://dx.doi.org/10.1038/s41586-019-1116-4DOI Listing

Coordinated signals from the DNA repair enzymes PARP-1 and PARP-2 promotes B-cell development and function.

Cell Death Differ 2019 Apr 17. Epub 2019 Apr 17.

Cancer Research Program, Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain.

Poly (ADP-ribose) polymerase (PARP)-1 and PARP-2 regulate the function of various DNA-interacting proteins by transferring ADP-ribose emerging from catalytic cleavage of cellular β-NAD. Hence, mice lacking PARP-1 or PARP-2 show DNA perturbations ranging from altered DNA integrity to impaired DNA repair. These effects stem from the central role that PARP-1 and PARP-2 have on the cellular response to DNA damage. Read More

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http://www.nature.com/articles/s41418-019-0326-5
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http://dx.doi.org/10.1038/s41418-019-0326-5DOI Listing
April 2019
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Aerosol Transmission of Gull-Origin Iceland Subtype H10N7 Influenza A Virus in Ferrets.

J Virol 2019 Apr 17. Epub 2019 Apr 17.

Department of Basic Science, College of Veterinary Medicine, Mississippi State University, Mississippi, United States

Subtype H10 influenza A viruses (IAVs) have been recovered from domestic poultry and various aquatic bird species, and sporadic transmission of these IAVs from avian species to mammals (i.e., human, seal, and mink) are well documented. Read More

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http://jvi.asm.org/lookup/doi/10.1128/JVI.00282-19
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http://dx.doi.org/10.1128/JVI.00282-19DOI Listing
April 2019
2 Reads