297,663 results match your criteria European Urology Supplements [Journal]


Benchmark of different assessment methods for non-sinusoidal magnetic field exposure in the context of European Directive 2013/35/EU.

J Radiol Prot 2019 Feb 22. Epub 2019 Feb 22.

Department of Physics, Aristotle University of Thessaloniki, University Campus, Thessaloniki, 54124, GREECE.

For the assessment of non-sinusoidal magnetic fields the European EMF Directive 2013/35/EU specified the Weighted Peak Method in Time Domain (WPM-TD) as the reference method. However, also other scientifically validated methods are allowed, provided that they lead to approximately equivalent and comparable results. In the non-binding guide for practical implementation of 2013/35/EU three methods alternative to the WPM-TD are described, i. Read More

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http://dx.doi.org/10.1088/1361-6498/ab0988DOI Listing
February 2019

Towards a conceptual model of affective predictions in palliative care.

J Pain Symptom Manage 2019 Feb 19. Epub 2019 Feb 19.

National Cancer Institute, Bethesda, MD, USA.

Context: Being diagnosed with cancer often forces patients and families to make difficult medical decisions. How patients think they and others will feel in the future, termed affective predictions, may influence these decisions. These affective predictions are often biased, which may contribute to suboptimal care outcomes by influencing decisions related to palliative care and advance care planning. Read More

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http://dx.doi.org/10.1016/j.jpainsymman.2019.02.008DOI Listing
February 2019

Potential Functional Variants in SMC2 and TP53 in the AURORA Pathway Genes and Risk of Pancreatic Cancer.

Carcinogenesis 2019 Feb 22. Epub 2019 Feb 22.

Duke Cancer Institute, Duke University Medical Center, Durham, NC, USA.

The AURORA pathway participates in mitosis and cell division, and alterations in mitosis and cell division can lead to carcinogenesis. Therefore, genetic variants in the AURORA pathway genes may be associated with susceptibility to pancreatic cancer. To test this hypothesis, we used three large, publically available pancreatic cancer genome-wide association studies (GWASs) datasets (PanScan I, II/III and PanC4) to assess the associations of 7,168 single nucleotide polymorphisms (SNPs) in a set of 62 genes of this pathway with pancreatic cancer risk (8,477 cases and 6,946 controls of European ancestry). Read More

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http://dx.doi.org/10.1093/carcin/bgz029DOI Listing
February 2019

Positive predictive value of the German notification system for infectious diseases: Surveillance data from eight local health departments, Berlin, 2012.

PLoS One 2019 22;14(2):e0212908. Epub 2019 Feb 22.

Department of Infectious Disease Epidemiology, Robert Koch Institute, Berlin, Germany.

The German Infection Protection Act requires notifying certain cases of infectious diseases to local health departments (LHD) in Germany. LHDs transmit notifications meeting case definitions to the national health authority, where the proportion of discarded notifications is not known. The proportion of discarded cases at the level of LHDs can be expressed as the positive predictive value (PPV) of the notification system. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212908PLOS
February 2019

The use of tail-anchored protein chimeras to enhance liposomal cargo delivery.

PLoS One 2019 22;14(2):e0212701. Epub 2019 Feb 22.

Division of Pharmacy and Optometry, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom.

Background: Liposomes are employed as drug delivery vehicles offering a beneficial pharmacokinetic/distribution mechanism for in vivo therapeutics. Therapeutic liposomes can be designed to target specific cell types through the display of epitope-specific targeting peptides on their surface. The majority of peptides are currently attached by chemical modification of lipid constituents. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212701PLOS
February 2019

Capturing the diversity of working age life-courses: A European perspective on cohorts born before 1945.

PLoS One 2019 22;14(2):e0212400. Epub 2019 Feb 22.

Faculty of Social Sciences, University of Helsinki, Helsinki, Finland.

Life-courses describe people's activities from the cradle to the grave. Because life-courses are typically complex, models are used to simplify their description. The most commonly used model is tripartite, representing lives in subsequent periods of education, work, and retirement. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212400PLOS
February 2019

Palliative Care Comes of Age in the 2018 Declaration of Astana.

J Palliat Med 2019 Mar;22(3):242

1 International Association for Hospice and Palliative Care, Houston, Texas.

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http://dx.doi.org/10.1089/jpm.2018.0615DOI Listing

Astroglial Cx30 sustains neuronal population bursts independently of gap-junction mediated biochemical coupling.

Glia 2019 Feb 22. Epub 2019 Feb 22.

Neuroglial Interactions in Cerebral Physiopathology, Center for Interdisciplinary Research in Biology, Collège de France, Centre National de la Recherche Scientifique UMR 7241, Institut National de la Santé et de la Recherche Médicale U1050, Labex Memolife, PSL Research University, Paris, France.

Astroglial networks mediated by gap junction channels contribute to neurotransmission and promote neuronal coordination. Connexin 30, one of the two main astroglial gap junction forming protein, alters at the behavioral level the reactivity of mice to novel environment and at the synaptic level excitatory transmission. However, the role and function of Cx30 at the neuronal network level remain unclear. Read More

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http://dx.doi.org/10.1002/glia.23591DOI Listing
February 2019

Comment on "Revisiting the carrageenan controversy: do we really understand the digestive fate and safety of carrageenan in our foods?" by S. David, C. S. Levi, L. Fahoum, Y. Ungar, E. G. Meyron-Holtz, A. Shpigelman and U. Lesmes, Food Funct., 2018, 9, 1344-1352.

Food Funct 2019 Feb 22. Epub 2019 Feb 22.

IONTOX, LLC, 4717 Campus Dr., Kalamazoo, MI 49008, USA.

Carrageenan (CGN) is a polysaccharide that is found in various types of sea weed. It is a common food additive used for its gelling and thickening properties and has been used safely throughout the world for decades. CGN is approved as Generally Recognized as Safe (GRAS) by the United States Food and Drug Administration and is also considered safe for the general population by the World Health Organizations Joint Expert Committee on Food Additive (JECFA) and the European Food Safety Authority. Read More

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http://dx.doi.org/10.1039/c8fo01282bDOI Listing
February 2019

Occupational medicine and occupational psychology: a rendezvous in Milan after World War II.

Med Lav 2019 Feb 22;110(1):63-74. Epub 2019 Feb 22.

Dipartimento di Scienze Cliniche e di Comunità. Università degli Studi di Milano.

Background: In the 1950s, occupational medicine and occupational psychology found a common field of action in the Clinica del Lavoro in Milan. OBJECTIVES This study aims to analyze and document how this encounter took place and, in particular, the contribution of the Clinica del Lavoro to the development of occupational psychology in Italy.

Methods: Historical sources of that period were investigated. Read More

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http://dx.doi.org/10.23749/mdl.v110i1.7799DOI Listing
February 2019

Work-related stress in the banking sector: a study on an Italian aged population of over 2,000 workers.

Med Lav 2019 Feb 22;110(1):11-21. Epub 2019 Feb 22.

.

Introduction: In the European Union, the employment rate for the population in the age group 55-64 years has greatly increased in the last two decades. Companies, especially in sectors such as banking, are looking for new strategies to improve the productivity of workers in this age group.

Objectives: This study was conceived with the purpose of exploring the associations between job characteristics that could influence stress and certain organizational aspects in a large population of banking workers. Read More

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http://dx.doi.org/10.23749/mdl.v110i1.7125DOI Listing
February 2019

Physicochemical and functional assessments demonstrating analytical similarity between rituximab biosimilar HLX01 and the MabThera®.

MAbs 2019 Feb 22:1-15. Epub 2019 Feb 22.

a Shanghai Henlius Biotech, Inc ., Shanghai , China.

Development of bio-therapeutics has exhibited exponential growth in China over the past decade. However, no biosimilar drug has been approved in China (CN) due to the lack of a national biosimilar regulatory guidance. HLX01, a rituximab biosimilar developed in China under European Medicines Agency biosimilar guidelines and requirements, was the first such drug submitted for regulatory review in China, and it is expected to receive approval there as a biosimilar product. Read More

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http://dx.doi.org/10.1080/19420862.2019.1578147DOI Listing
February 2019

European primary care research and a national general practice research agenda.

Authors:
Jelle Stoffers

Eur J Gen Pract 2019 Jan;25(1):3-4

a Department of Family Medicine , Care and Public Health Research Institute (CAPHRI), Maastricht University , Maastricht , The Netherlands.

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http://dx.doi.org/10.1080/13814788.2018.1559568DOI Listing
January 2019

Stan Maes: the founder of European Health Psychology.

Authors:
Marie Johnston

Psychol Health 2018 Nov;33(11):1317-1320

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http://dx.doi.org/10.1080/08870446.2018.1546801DOI Listing
November 2018

Cell Fate and Developmental Regulation Dynamics by Polycomb Proteins and 3D Genome Architecture.

Bioessays 2019 Feb 22. Epub 2019 Feb 22.

Institute of Human Genetics, UMR 9002, CNRS and University of Montpellier, 34396, Montpellier, France.

Targeted transitions in chromatin states at thousands of genes are essential drivers of eukaryotic development. Therefore, understanding the in vivo dynamics of epigenetic regulators is crucial for deciphering the mechanisms underpinning cell fate decisions. This review illustrates how, in addition to its cell memory function, the Polycomb group of transcriptional regulators orchestrates temporal, cell and tissue-specific expression of master genes during development. Read More

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http://dx.doi.org/10.1002/bies.201800222DOI Listing
February 2019

Associations between an Educational Attainment Polygenic Score with Educational Attainment in an African American Sample.

Genes Brain Behav 2019 Feb 21:e12558. Epub 2019 Feb 21.

Johns Hopkins University Bloomberg School of Public Health, Mental Health, Baltimore, Maryland.

Polygenic propensity for educational attainment has been associated with higher education attendance, academic achievement, and criminal offending in predominantly European samples; however, less is known about whether this polygenic propensity is associated with these outcomes among African Americans. Using an educational attainment polygenic score (EA PGS), the present study examined whether this score was associated with post-secondary education, academic achievement, and criminal offending in an urban, African American sample. Three cohorts of participants (N=1,050; 43. Read More

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http://dx.doi.org/10.1111/gbb.12558DOI Listing
February 2019

Age-dependent DNA methylation patterns on the Y chromosome in elderly males.

Aging Cell 2019 Feb 21:e12907. Epub 2019 Feb 21.

Epidemiology and Biostatistics, Department of Public Health, University of Southern Denmark, Odense, Denmark.

The Y chromosome, a sex chromosome that only exists in males, has been ignored in traditional epigenetic association studies for multiple reasons. However, sex differences in aging-related phenotypes and mortality could suggest a critical role of the sex chromosomes in the aging process. We obtained blood-based DNA methylation data on the Y chromosome for 624 men from four cohorts and performed a chromosome-wide epigenetic association analysis to detect Y-linked CpGs differentially methylated over age and cross-validated the significant CpGs in the four cohorts. Read More

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http://dx.doi.org/10.1111/acel.12907DOI Listing
February 2019

From clear lakes to murky waters - tracing the functional response of high-latitude lake communities to concurrent 'greening' and 'browning'.

Ecol Lett 2019 Feb 21. Epub 2019 Feb 21.

Kilpisjärvi Biological Station, University of Helsinki, Helsinki, Finland.

Climate change and the intensification of land use practices are causing widespread eutrophication of subarctic lakes. The implications of this rapid change for lake ecosystem function remain poorly understood. To assess how freshwater communities respond to such profound changes in their habitat and resource availability, we conducted a space-for-time analysis of food-web structure in 30 lakes situated across a temperature-productivity gradient equivalent to the predicted future climate of subarctic Europe (temperature +3°C, precipitation +30% and nutrient +45 μg L total phosphorus). Read More

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http://dx.doi.org/10.1111/ele.13238DOI Listing
February 2019

Safe Paediatric Procedural Sedation and Anagesia by Anaesthesiologists for elective procedures: a Clinical Practice Statement from the European Society for Pediatric Anaesthesiology.

Paediatr Anaesth 2019 Feb 21. Epub 2019 Feb 21.

Retired Reader in Paediatric Anaesthesia and Pain Management, University of Glasgow, Glasgow, Scotland, UK.

The growing number of medical procedures performed in children that require cooperation of patients, lack of movement, anxiolysis or/and analgesia triggers the increased need for procedural sedation. This document presents the consensus statement of the European Society for Paediatric Anaesthesiology about the principles connected with the safe management of procedural sedation and analgesia (PSA) by anaesthesiologists for elective procedures in children. It does not aim to provide a legal statement on how and by whom PSA should be performed. Read More

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http://dx.doi.org/10.1111/pan.13615DOI Listing
February 2019

Do Telomeres Influence Pace-of-Life-Strategies in Response to Environmental Conditions Over a Lifetime and Between Generations?

Bioessays 2019 Feb 21:e1800162. Epub 2019 Feb 21.

Institute of Ecology and Earth Sciences, University of Tartu, Vanemuise 46, 51014, Tartu, Estonia.

The complexity of the physiological phenotype currently prevents us from identifying an integrative measure to assess how the internal state and environmental conditions modify life-history strategies. In this article, it is proposed that shorter telomeres should lead to a faster pace-of-life where investment in self-maintenance is decreased as a means of saving energy for reproduction, but at the cost of somatic durability. Inversely, longer telomeres would favor an increased investment in soma maintenance and thus a longer reproductive lifespan (i. Read More

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http://dx.doi.org/10.1002/bies.201800162DOI Listing
February 2019

Application of the relationship between pharmacokinetics and pharmacodynamics in drug development and therapeutic equivalence: a PEARRL review.

J Pharm Pharmacol 2019 Feb 22. Epub 2019 Feb 22.

Institute of Pharmaceutical Technology, Goethe University, Frankfurt am Main, Germany.

Objectives: The objective of this review was to provide an overview of pharmacokinetic/pharmacodynamic (PK/PD) models, focusing on drug-specific PK/PD models and highlighting their value added in drug development and regulatory decision-making.

Key Findings: Many PK/PD models, with varying degrees of complexity and physiological understanding have been developed to evaluate the safety and efficacy of drug products. In special populations (e. Read More

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http://dx.doi.org/10.1111/jphp.13070DOI Listing
February 2019

Trabecular architecture of the great ape and human femoral head.

J Anat 2019 Feb 21. Epub 2019 Feb 21.

Skeletal Biology Research Centre, School of Anthropology and Conservation, University of Kent, Canterbury, UK.

Studies of femoral trabecular structure have shown that the orientation and volume of bone are associated with variation in loading and could be informative about individual joint positioning during locomotion. In this study, we analyse for the first time trabecular bone patterns throughout the femoral head using a whole-epiphysis approach to investigate how potential trabecular variation in humans and great apes relates to differences in locomotor modes. Trabecular architecture was analysed using microCT scans of Pan troglodytes (n = 20), Gorilla gorilla (n = 14), Pongo sp. Read More

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http://dx.doi.org/10.1111/joa.12957DOI Listing
February 2019
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CausalTAB: the PSI-MITAB 2.8 updated format for signalling data representation and dissemination.

Bioinformatics 2019 Feb 21. Epub 2019 Feb 21.

Department of Biology, University of Rome Tor Vergata, Rome, Italy.

Motivation: Combining multiple layers of information underlying biological complexity into a structured framework represent a challenge in systems biology. A key task is the formalisation of such information in models describing how biological entities interact to mediate the response to external and internal signals. Several databases with signalling information, focus on capturing, organising and displaying signalling interactions by representing them as binary, causal relationships between biological entities. Read More

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https://academic.oup.com/bioinformatics/advance-article/doi/
Publisher Site
http://dx.doi.org/10.1093/bioinformatics/btz132DOI Listing
February 2019
1 Read

Differences in Genomic Profiles and Outcomes between Thoracic and Adrenal Neuroblastoma.

J Natl Cancer Inst 2019 Feb 21. Epub 2019 Feb 21.

Department of Pediatrics, Childrens Hospital of Philadelphia and Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.

Background: Neuroblastoma is a biologically and clinically heterogeneous disease. Based on recent studies demonstrating an association between the primary tumor site, prognosis, and commonly measured tumor biological features, we hypothesized that neuroblastomas arising in different sites would show distinct genomic features reflective of the developmental biology of the sympathicoadrenal nervous system.

Methods: We first compared genomic and epigenomic data of primary diagnostic neuroblastomas originating in the adrenal gland (N = 646) compared to thoracic sympathetic ganglia (N = 118). Read More

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http://dx.doi.org/10.1093/jnci/djz027DOI Listing
February 2019

A large CRISPR-induced bystander mutation causes immune dysregulation.

Commun Biol 2019 18;2:70. Epub 2019 Feb 18.

2Department of Microbiology and Immunology, University of California, San Francisco, CA 94143 USA.

A persistent concern with CRISPR-Cas9 gene editing has been the potential to generate mutations at off-target genomic sites. While CRISPR-engineering mice to delete a ~360 bp intronic enhancer, here we discovered a founder line that had marked immune dysregulation caused by a 24 kb tandem duplication of the sequence adjacent to the on-target deletion. Our results suggest unintended repair of on-target genomic cuts can cause pathogenic "bystander" mutations that escape detection by routine targeted genotyping assays. Read More

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http://dx.doi.org/10.1038/s42003-019-0321-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379443PMC
February 2019

Morphological Seed Characterization of Common ( L.) and Runner ( L.) Bean Germplasm: A Slovenian Gene Bank Example.

Biomed Res Int 2019 16;2019:6376948. Epub 2019 Jan 16.

Crop Science Department, Agricultural Institute of Slovenia, Hacquetova Ulica 17, 1000 Ljubljana, Slovenia.

Genetic resources comprised of 953 accessions of common ( L.) and 47 accessions of runner ( L.) bean from the national Slovene gene bank were characterized using fourteen morphological seed descriptors. Read More

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http://dx.doi.org/10.1155/2019/6376948DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354170PMC
January 2019

Research highlights from the 2018 ERS International Congress: interstitial lung diseases.

ERJ Open Res 2019 Feb 18;5(1). Epub 2019 Feb 18.

Dept of Diseases of the Thorax, Ospedale GB Morgagni, Forlì, Italy.

This article reviews a selection of the scientific presentations on interstitial lung disease (ILD)/diffuse parenchymal lung disease (DPLD) that were made at the 2018 European Respiratory Society (ERS) International Congress in Paris. A number of advances in the epidemiology, pathogenesis, diagnosis and treatment of these disorders were presented and discussed by clinicians and researchers. The research topics span over all four groups of ERS Assembly 12: Interstitial Lung Diseases (Group 12. Read More

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http://dx.doi.org/10.1183/23120541.00215-2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378342PMC
February 2019

Implementation of infection prevention and control in acute care hospitals in Mainland China - a systematic review.

Antimicrob Resist Infect Control 2019 11;8:32. Epub 2019 Feb 11.

Infection Control Program and WHO Collaborating Centre on Patient Safety, University of Geneva Hospitals and Faculty of Medicine, Rue Gabrielle Perret-Gentil 4, 1211 Geneva 14, Switzerland.

Background: Healthcare-associated infections (HAIs) and antimicrobial resistance (AMR) affect patients in acute-care hospitals worldwide. No systematic review has been published on adoption and implementation of the infection prevention and control (IPC) key components. The objective of this systematic review was to assess adoption and implementation of the three areas issued by the "National Health Commission of the People's Republic of China" in acute-care hospitals in Mainland China, and to compare the findings with the key and core components on effective IPC, issued by the European Centre for Disease Prevention and Control (ECDC) and the World Health Organization (WHO). Read More

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http://dx.doi.org/10.1186/s13756-019-0481-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371478PMC
February 2019

Triple-negative breast cancer: the reality in Chile and in Latin America.

Ecancermedicalscience 2019 22;13:893. Epub 2019 Jan 22.

Oncology Institute Arturo López Pérez Foundation, Santiago 878, Chile.

Breast cancer is the leading cause of cancer death among women worldwide. While triple-negative breast cancer is less common among various sub-types of breast cancer, it tends to affect younger women and is more aggressive, having a higher rate of early recurrence and mortality compared to other sub-types. We know about the association between triple-negative breast cancer and BRCA mutations, which are highly prevalent in founding populations of European origin, but the true prevalence of these mutations in Latin American populations is unknown. Read More

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http://dx.doi.org/10.3332/ecancer.2019.893DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372297PMC
January 2019

Adrenal Aging and Its Implications on Stress Responsiveness in Humans.

Front Endocrinol (Lausanne) 2019 7;10:54. Epub 2019 Feb 7.

School of Medicine, European University Cyprus, Nicosia, Cyprus.

Normal aging results in subtle changes both in ACTH and cortisol secretion. Most notable is the general increase in mean daily serum cortisol levels in the elderly, without a noteworthy alteration in the normal circadian rhythm pattern. Glucocorticoid excess seen in the elderly population can have serious consequences in both the structural and functional integrity of various key areas in the brain, including the hippocampus, amygdala, prefrontal cortex, with consequent impairment in normal memory, cognitive function, and sleep cycles. Read More

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http://dx.doi.org/10.3389/fendo.2019.00054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374303PMC
February 2019

Splenic Injury with Subsequent Pleural Effusion: An Underreported Complication of Colonoscopy.

Case Rep Gastroenterol 2019 Jan-Apr;13(1):6-11. Epub 2019 Jan 10.

Department of Internal Medicine, Blake Medical Center, Bradenton, Florida, USA.

Colorectal cancer is a leading cause of morbidity and mortality worldwide. As such, there are recognized guidelines in the screening of this preventable cancer. There are differences in opinion regarding screening recommendations between the European and United States Cancer Prevention Societies. Read More

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http://dx.doi.org/10.1159/000494917DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381898PMC
January 2019

Author Correction: Inference of ecological and social drivers of human brain-size evolution.

Nature 2019 Feb 21. Epub 2019 Feb 21.

School of Biology, University of St Andrews, St Andrews, UK.

In the Acknowledgements section of this Letter, the words "M.G.-F. Read More

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http://dx.doi.org/10.1038/s41586-019-0950-8DOI Listing
February 2019

Octa-repeat domain of the mammalian prion protein mRNA forms stable A-helical hairpin structure rather than G-quadruplexes.

Sci Rep 2019 Feb 21;9(1):2465. Epub 2019 Feb 21.

Institute of Biochemistry and Molecular Biology University of Hamburg, Hamburg, Germany.

Misfolding and aggregation of prion protein (PrP) causes neurodegenerative diseases like Creutzfeldt-Jakob disease (CJD) and scrapie. Besides the consensus that spontaneous conversion of normal cellular PrP into misfolded and aggregating PrP is the central event in prion disease, an alternative hypothesis suggests the generation of pathological PrP by rare translational frameshifting events in the octa-repeat domain of the PrP mRNA. Ribosomal frameshifting most commonly relies on a slippery site and an adjacent stable RNA structure to stall translating ribosome. Read More

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http://dx.doi.org/10.1038/s41598-019-39213-2DOI Listing
February 2019

Vascular Type of Ehlers-Danlos Syndrome: A Case Report of an Aortic Dissection During Pregnancy.

Am J Case Rep 2019 Feb 22;20:233-237. Epub 2019 Feb 22.

Clinic for Cardiology, Pneumology and Angiology, University Hospital of Düsseldorf, Düsseldorf, Germany.

BACKGROUND Vascular type of Ehlers-Danlos syndrome (vEDS) is a rare connective tissue disorder associated with a high prevalence rate of aortic dissection (AD). The coexistence of a pregnancy raises these rates and the diagnostic complexity of the situation. In this article, we present a different initial diagnostic approach to an acute aortic syndrome. Read More

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http://dx.doi.org/10.12659/AJCR.911688DOI Listing
February 2019

Compact radio emission indicates a structured jet was produced by a binary neutron star merger.

Science 2019 Feb 21. Epub 2019 Feb 21.

Xinjiang Astronomical Observatory, Chinese Academy of Sciences, 150 Science 1-Street, Urumqi 831001, China.

The binary neutron star merger event GW170817 was detected through both electromagnetic radiation and gravitational waves. Its afterglow emission may have been produced by either a narrow relativistic jet or an isotropic outflow. High-spatial-resolution measurements of the source size and displacement can discriminate between these scenarios. Read More

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http://dx.doi.org/10.1126/science.aau8815DOI Listing
February 2019

Epidemiology and long-term outcome in outpatients with chronic heart failure in Northwestern Europe.

Heart 2019 Feb 21. Epub 2019 Feb 21.

Fagavdelingen, St Olavs Hospital, Trondheim, Norway.

Objective: To describe the epidemiology, long-term outcomes and temporal trends in mortality in ambulatory patients with chronic heart failure (HF) with reduced (HFrEF), mid-range (HFmrEF) or preserved ejection fraction (HFpEF) from three European countries.

Methods: We identified 10 312 patients from the Norwegian HF Registry and the HF registries of the universities of Heidelberg, Germany, and Hull, UK. Patients were classified according to baseline left ventricular ejection fraction (LVEF) and time of enrolment (period 1: 1995-2005 vs period 2: 2006-2015). Read More

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http://dx.doi.org/10.1136/heartjnl-2018-314256DOI Listing
February 2019

Energy metabolism is co-determined by genetic variants in chronic lymphocytic leukemia and influences drug sensitivity.

Haematologica 2019 Feb 21. Epub 2019 Feb 21.

European Molecular Biology Laboratory (EMBL), Heidelberg, Germany;

Chronic lymphocytic leukemia cells have an altered energy metabolism compared to normal B cells. While there is growing understanding of the molecular heterogeneity of the disease, the extent of metabolic heterogeneity and its relation to molecular heterogeneity has not been systematically studied. Here, we assessed 11 bioenergetic features, primarily reflecting cell's oxidative phosphorylation and glycolytic activity, in leukemic cells from 140 chronic lymphocytic leukemia patients using metabolic flux analysis. Read More

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http://dx.doi.org/10.3324/haematol.2018.203067DOI Listing
February 2019

An NAD Phosphorylase Toxin Triggers Mycobacterium tuberculosis Cell Death.

Mol Cell 2019 Feb 8. Epub 2019 Feb 8.

Institut de Pharmacologie et de Biologie Structurale, IPBS, Université de Toulouse, CNRS, UPS, 205 route de Narbonne, 31400 Toulouse, France. Electronic address:

Toxin-antitoxin (TA) systems regulate fundamental cellular processes in bacteria and represent potential therapeutic targets. We report a new RES-Xre TA system in multiple human pathogens, including Mycobacterium tuberculosis. The toxin, MbcT, is bactericidal unless neutralized by its antitoxin MbcA. Read More

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http://dx.doi.org/10.1016/j.molcel.2019.01.028DOI Listing
February 2019

Educational Value of Surgical Multidisciplinary Team Meetings for Learning Non-Technical Skills - A Pilot Survey of Trainees From Two UK Deaneries.

J Surg Educ 2019 Feb 19. Epub 2019 Feb 19.

Warwick Medical School, Warwickshire, United Kingdom; Department of Upper Gastro-Intestinal Surgery, Queen Alexandra Hospital, Portsmouth, Hampshire, United Kingdom. Electronic address:

Objective: This prospective survey study aimed to identify trainee surgeons' views on the educational potential of multi-disciplinary team (MDT) meetings for learning non-technical skills and relevant issues around using MDT meetings as an educational instrument.

Design: An online survey questionnaire containing eight closed and three open-ended questions; was developed based on established educational theories. Responses were anonymous. Read More

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http://dx.doi.org/10.1016/j.jsurg.2019.02.001DOI Listing
February 2019

Ethnoracial differences in Alzheimer's disease from the FLorida Autopsied Multi-Ethnic (FLAME) cohort.

Alzheimers Dement 2019 Feb 12. Epub 2019 Feb 12.

Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA. Electronic address:

Introduction: Our primary goal was to examine demographic and clinicopathologic differences across an ethnoracially diverse autopsy-confirmed cohort of Alzheimer's disease cases.

Methods: A retrospective study was conducted in the Florida Autopsied Multi-Ethnic cohort on 1625 Alzheimer's disease cases, including decedents who self-reported as Hispanic/Latino (n = 67), black/African American (n = 19), and white/European American (n = 1539).

Results: Hispanic decedents had a higher frequency of family history of cognitive impairment (58%), an earlier age at onset (median age of 70 years), longer disease duration (median of 12 years), and lower MMSE proximal to death (median of 4 points) compared with the other ethnoracial groups. Read More

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http://dx.doi.org/10.1016/j.jalz.2018.12.013DOI Listing
February 2019

Harmonization of Pharmacovigilance Regulation in Brazil: Opportunities to Improve Risk Communication.

Clin Ther 2019 Feb 18. Epub 2019 Feb 18.

Department of Drugs and Medicines, School of Pharmaceutical Sciences, São Paulo State University, Araraquara, Brazil. Electronic address:

Brazilian pharmacovigilance regulations involve 3 spheres: health services, Marketing Authorization Holders (MAHs), and sanitary agency. Drug tolerability began to be effectively assessed in Brazil after the founding of the National Agency of Sanitary Surveillance, which developed the Sentinel Network Project. The objective of the Sentinel Network Project is to increase the adverse drug reaction (ADR) reporting rate by health care professionals in the hospital setting. Read More

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http://dx.doi.org/10.1016/j.clinthera.2019.01.013DOI Listing
February 2019

Accelerated DNA Methylation Aging in U.S. Military Veterans: Results From the National Health and Resilience in Veterans Study.

Am J Geriatr Psychiatry 2019 Jan 7. Epub 2019 Jan 7.

Department of Psychiatry (JLM, SMS, JHK, RHP), Yale University School of Medicine, New Haven, CT; Clinical Neurosciences Division (SMS, JHK, RHP), U.S. Department of Veterans Affairs National Center for Posttraumatic Stress Disorder, VA Connecticut Healthcare System, West Haven, CT; Yale School of Public Health (BRL, RHP), New Haven, CT.

Objective: The aim of this study was to identify how a broad range of sociodemographic, military, health, and psychosocial factors relate to accelerated DNA methylation aging (Δ) in a large, contemporary, nationally representative sample of male U.S. veterans. Read More

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http://dx.doi.org/10.1016/j.jagp.2019.01.001DOI Listing
January 2019

PRISM study: Comparison of a nystatin-neomycin-polymyxin B combination with miconazole for the empirical treatment of infectious vaginitis.

Med Mal Infect 2019 Feb 18. Epub 2019 Feb 18.

Laboratoire Innotech International, Groupe Innothera, 22, avenue Aristide-Briand, 94110 Arcueil, France.

Objective: An empirical treatment of infectious vaginitis is justified because of its multiple etiologies, the frequent uncertainty of clinical diagnosis and limits of microbiological analysis. Our aim was to comparatively investigate nystatin-neomycin-polymyxin B combination (NNP, Polygynax) and miconazole.

Patients And Methods: In this European multicenter, double-blind PRISM trial, participating women presenting with infectious vaginitis were randomized to receive one vaginal capsule containing either NNP for 12 days or miconazole for 3 days followed by 9 days of placebo. Read More

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http://dx.doi.org/10.1016/j.medmal.2019.01.011DOI Listing
February 2019

The impact of peripheral artery disease on left ventricular diastolic function.

J Cardiol 2019 Feb 18. Epub 2019 Feb 18.

Division of Cardiovascular Medicine and Coronary Heart Disease, Hyogo College of Medicine, Nishinomiya, Japan. Electronic address:

Background: Peripheral artery disease (PAD) is often accompanied by heart failure with preserved ejection fraction (HFpEF). Left ventricular (LV) diastolic dysfunction is related to HFpEF. The aim of this study was to compare LV diastolic function between patients with or without PAD. Read More

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http://dx.doi.org/10.1016/j.jjcc.2019.01.011DOI Listing
February 2019

Behavioral and Psychologic Symptoms in Patients With Pulmonary Hypertension: A Response to Doğan et al.

Psychosomatics 2019 Jan 23. Epub 2019 Jan 23.

School of Biomedical Sciences, European University of Madrid, National Association of Pulmonary Hypertension, Madrid, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.psym.2019.01.004DOI Listing
January 2019

The hazards and risks of inhaled poorly soluble particles - where do we stand after 30 years of research?

Part Fibre Toxicol 2019 Feb 21;16(1):11. Epub 2019 Feb 21.

Ernest Mario School of Pharmacy, Rutgers University, New Jersey, USA.

Background: In 2006, titanium dioxide and carbon black were classified by IARC as "possibly carcinogenic to humans" and in 2017 the European Chemicals Agency's (ECHA) Committee for Risk Assessment concluded titanium dioxide meets the criteria to be classified as suspected of causing cancer (category 2, through the inhalation route). These classifications were based primarily on the occurrence of lung cancer in rats exposed chronically to high concentrations of these materials, as no such responses have been observed in other animal species similarly exposed. After the EU classification of titanium dioxide, it was suggested that Poorly Soluble particles of Low Toxicity (PSLTs) can be evaluated as a group. Read More

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http://dx.doi.org/10.1186/s12989-019-0294-4DOI Listing
February 2019

Genomic analyses of an extensive collection of wild and cultivated accessions provide new insights into peach breeding history.

Genome Biol 2019 Feb 21;20(1):36. Epub 2019 Feb 21.

Zhengzhou Fruit Research Institute, Chinese Academy of Agricultural Sciences, Zhengzhou, China.

Background: Human selection has a long history of transforming crop genomes. Peach (Prunus persica) has undergone more than 5000 years of domestication that led to remarkable changes in a series of agronomically important traits, but genetic bases underlying these changes and the effects of artificial selection on genomic diversity are not well understood.

Results: Here, we report a comprehensive analysis of peach evolution based on genome sequences of 480 wild and cultivated accessions. Read More

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http://dx.doi.org/10.1186/s13059-019-1648-9DOI Listing
February 2019

Epigenetic signatures associated with imprinted paternally expressed genes in the Arabidopsis endosperm.

Genome Biol 2019 Feb 21;20(1):41. Epub 2019 Feb 21.

Department of Plant Biology, Uppsala BioCenter, Swedish University of Agricultural Sciences and Linnean Center for Plant Biology, Uppsala, Sweden.

Background: Imprinted genes are epigenetically modified during gametogenesis and maintain the established epigenetic signatures after fertilization, causing parental-specific gene expression.

Results: In this study, we show that imprinted paternally expressed genes (PEGs) in the Arabidopsis endosperm are marked by an epigenetic signature of Polycomb Repressive Complex2 (PRC2)-mediated H3K27me3 together with heterochromatic H3K9me2 and CHG methylation, which specifically mark the silenced maternal alleles of PEGs. The co-occurrence of H3K27me3 and H3K9me2 on defined loci in the endosperm drastically differs from the strict separation of both pathways in vegetative tissues, revealing tissue-specific employment of repressive epigenetic pathways in plants. Read More

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http://dx.doi.org/10.1186/s13059-019-1652-0DOI Listing
February 2019