2,446 results match your criteria European Surgical Research[Journal]


Microvascular Mechanisms of Polyphosphate-Induced Neutrophil-Endothelial Cell Interactions in vivo.

Eur Surg Res 2019 Mar 25;60(1-2):53-62. Epub 2019 Mar 25.

Department of Clinical Sciences, Section of Surgery, Lund University, Malmö, Sweden,

Background: Polyphosphates (PolyPs) have been reported to exert pro-inflammatory effects. However, the molecular mechanisms regulating PolyP-provoked tissue accumulation of leukocytes are not known. The aim of the present investigation was to determine the role of specific adhesion molecules in PolyP-mediated leukocyte recruitment. Read More

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https://www.karger.com/Article/FullText/497435
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http://dx.doi.org/10.1159/000497435DOI Listing
March 2019
2 Reads

Abstracts: 136th Congress of the German Society of Surgery (DGCH).

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Eur Surg Res 2019 18;60 Suppl 1:1-33. Epub 2019 Mar 18.

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http://dx.doi.org/10.1159/000498929DOI Listing

Intraoperative Sentinel Node Mapping in the Colon: Potential and Pitfalls.

Authors:
Andrew C Currie

Eur Surg Res 2019 Feb 22;60(1-2):45-52. Epub 2019 Feb 22.

Department of Surgery, St Richard's Hospital, Chichester, United Kingdom,

Sentinel lymph node mapping (SLNM) may play a significant role in future delivery of colon cancer surgery because of an increase in early-stage, node-negative disease due to national bowel cancer screening programmes. Traditionally, colon lymphatic drainage has not been thought relevant as the operative approach cannot be tailored. Recent advances in local and endoscopic risk-reducing interventions for colonic malignancy have caused a rethink in approach. Read More

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http://dx.doi.org/10.1159/000494833DOI Listing
February 2019
1 Read

Kinetics of Hepatic Volume Evolution and Architectural Changes after Major Resection in a Porcine Model.

Eur Surg Res 2019 Feb 13;60(1-2):31-44. Epub 2019 Feb 13.

Centre Hépato-Biliaire, AP-HP, Hôpital Paul Brousse, Villejuif, France.

Background: The hepatic volume gain following resection is essential for clinical recovery. Previous studies have focused on cellular regeneration. This study aims to explore the rate of hepatic regeneration of the porcine liver following major resection, highlighting estimates of the early microarchitectural changes that occur during the cellular regeneration. Read More

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http://dx.doi.org/10.1159/000491691DOI Listing
February 2019

Can Surgical Registrars Accurately Identify the Urgent from the Non-Urgent Patient Presenting with Acute Abdominal Pain?

Eur Surg Res 2019 Feb 6;60(1-2):24-30. Epub 2019 Feb 6.

Department of General Surgery, Wellington Regional Hospital, Wellington, New Zealand.

Background: Acute abdominal pain is a common surgical presentation with a wide range of causes. Differentiating urgent patients from non-urgent patients is important to optimise patient outcomes and the use of hospital resources. The aim of this study was to determine how accurately urgent and non-urgent patients presenting with abdominal pain can be identified. Read More

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https://www.karger.com/Article/FullText/496021
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http://dx.doi.org/10.1159/000496021DOI Listing
February 2019
9 Reads

Vascular Biomaterial Banking in Academia.

Eur Surg Res 2019 Feb 6;60(1-2):13-23. Epub 2019 Feb 6.

Department of Vascular and Endovascular Surgery, University of Heidelberg, Heidelberg, Germany,

Background/purpose: To establish a high-quality vascular biomaterial bank to serve vascular research teams and act as a basis for translational medicine. The aim was to collect and store material so that investigation into the pathogenesis of vascular disease would be possible employing methods based on histopathology and/or molecular biology.

Methods: The Vascular Biomaterialbank Heidelberg (VBBH) evolved as part of an established, partly accredited biobank complex at the University of Heidelberg (BioMaterialBank Heidelberg - BMBH). Read More

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http://dx.doi.org/10.1159/000495525DOI Listing
February 2019
1 Read

Downregulation of SPARC Is Associated with Epithelial-Mesenchymal Transition and Low Differentiation State of Biliary Tract Cancer Cells.

Eur Surg Res 2019 Jan 16;60(1-2):1-12. Epub 2019 Jan 16.

Department of Medicine II, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany,

Background: Biliary tract cancers (BTCs) have a poor prognosis. BTCs are characterized by a prominent desmoplastic reaction which possibly contributes to the aggressive phenotype of this tumor. The desmoplastic reaction includes excessive production and deposition of extracellular matrix proteins such as periostin, secreted protein acidic and rich in cysteine (SPARC), thrombospondin-1, as well as accumulation of α-smooth muscle actin-positive cancer-associated fibroblasts and immune cells, secreting growth factors and cytokines including transforming growth factor (TGF)-β. Read More

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https://www.karger.com/Article/FullText/494734
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http://dx.doi.org/10.1159/000494734DOI Listing
January 2019
7 Reads

The Short- and Long-Term Outcomes in Elderly Patients with Hepatocellular Carcinoma after Curative Surgery: A Case-Controlled Study with Propensity Score Matching.

Eur Surg Res 2018 14;59(5-6):380-390. Epub 2018 Dec 14.

Division of Hepato-Biliary-Pancreatic Surgery, Shizuoka Cancer Center Hospital, Shizuoka, Japan.

Background: With aging populations increasing in developed countries, the prevalence of elderly patients with hepatocellular carcinoma (HCC) is expected to rise. The aim of this study was to determine the short- and long-term outcomes of HCC surgery in elderly patients (≥75 years) using propensity score matching.

Methods: The study group included 421 patients who underwent hepatectomy as their initial treatment with curative intent. Read More

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http://dx.doi.org/10.1159/000494733DOI Listing
December 2018
1 Read

Biology-Based Surgery: The Extent of Lymphadenectomy in Cancer of the Colon.

Eur Surg Res 2018 13;59(5-6):371-379. Epub 2018 Dec 13.

Department of GI Surgery and Cancer Research Institute Ghent (CRIG), Ghent University Hospital, Ghent, Belgium,

The progression of colon cancer (CC) involves hematogenous and lymphatic spread to locoregional lymph nodes (LN), distant LN, and metastatic sites including the liver. The biological mechanisms that govern CC progression remain elusive. The Halsted model assumes an orderly, stepwise progression from the primary tumor to nearby nodes, henceforth to anatomically more distant nodes, and ultimately to distant organs. Read More

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http://dx.doi.org/10.1159/000494831DOI Listing
December 2018
4 Reads

GLP1 Receptor Agonist Liraglutide Is an Effective Therapeutic Option for Perioperative Glycemic Control in Type 2 Diabetes within Enhanced Recovery After Surgery (ERAS) Protocols.

Eur Surg Res 2018 11;59(5-6):349-360. Epub 2018 Dec 11.

Division of Diabetes/Endocrinology/Lifestyle-Related Disease, Takatsuki Red Cross Hospital, Takatsuki, Japan.

Background: Enhanced Recovery After Surgery (ERAS) protocols are multimodal perioperative care pathways designed to achieve early recovery after surgical procedures by maintaining preoperative organ function and reducing profound stress responses following surgery [Wilmore and Kehlet: BMJ 2001; 322(7284): 473-6]. Glucagon-like peptide-1 receptor agonists (GLP-1RAgs), such as liraglutide, have recently been widely used as antidiabetic agents in patients with type 2 diabetes (T2D) because they maintain blood glucose at an ideal level throughout the day, including during postprandial periods, thereby improving hypoglycemia and body weight more than insulin therapies. Additionally, the administration of liraglutide may exert cardiovascular, renal, and cerebral protective effects in T2D patients. Read More

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http://dx.doi.org/10.1159/000494768DOI Listing
December 2018
2 Reads

Biology of Nodal Spread in Colon Cancer: Insights from Molecular and Genetic Studies.

Eur Surg Res 2018 11;59(5-6):361-370. Epub 2018 Dec 11.

Division of Colorectal Surgery, Department of Surgery, University of Michigan, Ann Arbor, Michigan, USA,

Colorectal cancer (CRC) lymph node metastases are common but their genetics and the mechanism whereby these metastases occur are not well understood. Here we present recent data regarding genetic heterogeneity in primary CRCs and their metastasis. In addition, we explain the different potential models describing the mechanisms of metastasis and the data supporting them. Read More

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http://dx.doi.org/10.1159/000494832DOI Listing
December 2018
1 Read

Microsurgical Technique of Locoregional Injection into the Hepatic Artery in Tumor-Bearing Mice.

Eur Surg Res 2018 22;59(5-6):339-348. Epub 2018 Nov 22.

Clinic of General, Visceral and Transplantation Surgery, University Hospital Heidelberg, Heidelberg, Germany,

Background: Intraarterial injection into the hepatic artery represents an important route for locoregional administration for the treatment of hepatic tumors. In the present work, we describe microsurgical methodology for injection into the hepatic artery in mice. The technique was recently used for analysis of the phenomenon of endothelial capture in liver tumors. Read More

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http://dx.doi.org/10.1159/000494429DOI Listing
November 2018
2 Reads

The 53rd Congress of the European Society for Surgical Research.

Authors:

Eur Surg Res 2018 20;59 Suppl 2:1-103. Epub 2018 Nov 20.

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http://dx.doi.org/10.1159/000494706DOI Listing
November 2018
1 Read

Predictive Early Recurrence Factors of Preoperative Clinicophysiological Findings in Pancreatic Cancer.

Eur Surg Res 2018 19;59(5-6):329-338. Epub 2018 Nov 19.

Department of Gastrointestinal and Pediatric Surgery, Tokyo Medical University, Tokyo, Japan.

Background: We aimed to evaluate the use of preoperative clinicophysiological parameters as predictive risk factors for early recurrence of pancreatic ductal adenocarcinoma (PDAC) after curative resection.

Methods: A total of 260 patients who underwent pancreatic resection for PDAC between 2007 and 2015 were examined retrospectively. We divided the patients into those with early recurrence (within 6 months; group A, n = 52) and those with relapse within ≥6 months or without recurrence (group B, n = 208). Read More

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https://www.karger.com/Article/FullText/494382
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http://dx.doi.org/10.1159/000494382DOI Listing
November 2018
13 Reads

Isoform-Dependent Changes in Cytochrome P450-Mediated Drug Metabolism after Portal Vein Ligation in the Rat.

Eur Surg Res 2018 12;59(5-6):301-319. Epub 2018 Nov 12.

Institute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary,

Background: Surgical removal of complicated liver tumors may be realized in two stages via selective portal vein ligation, inducing the atrophy of portally ligated lobes and the compensatory hypertrophy of nonligated liver lobes. Unlike morphological changes, functional aspects such as hepatic cytochrome P450 (CYP)-mediated drug metabolism remain vaguely understood, despite its critical role in both drug biotransformation and hepatic functional analysis. Our goal was the multilevel characterization of hepatic CYP-mediated drug metabolism after portal vein ligation in the rat. Read More

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http://dx.doi.org/10.1159/000493923DOI Listing
November 2018
1 Read

A New Physiologic Mouse Model of One Anastomosis Gastric Bypass.

Eur Surg Res 2018 12;59(5-6):320-328. Epub 2018 Nov 12.

Department of General, Visceral, and Transplantation Surgery, University Hospital RWTH Aachen, Aachen, Germany.

Background: One anastomosis gastric bypass (OAGB) is a modern metabolic operation that has been demonstrated to be a rapid, safe, and effective procedure. As for other bariatric operations, the mechanisms and long-term effects of this procedure remain largely unknown and are difficult to address in human studies. Here, we present a new physiologic mouse model for mechanistic and long-term investigations. Read More

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http://dx.doi.org/10.1159/000493385DOI Listing
November 2018
2 Reads

The Crucial Role of Vascularization and Lymphangiogenesis in Skin Reconstruction.

Eur Surg Res 2018 21;59(3-4):242-254. Epub 2018 Sep 21.

Division of Plastic Surgery and Hand Surgery, University Hospital Zürich, University of Zürich, Zürich, Switzerland.

Background: The treatment of extensive skin defects and bradytrophic wounds remains a challenge in clinical practice. Despite emerging tissue engineering approaches, skin grafts and dermal substitutes are still the routine procedure for the majority of skin defects. Here, we review the role of vascularization and lymphangiogenesis for skin grafting and dermal substitutes from the clinician's perspective. Read More

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http://dx.doi.org/10.1159/000492413DOI Listing
March 2019
19 Reads

Panta Rhei: Neovascularization, Angiogenesis and Nutritive Perfusion in Wound Healing.

Eur Surg Res 2018 21;59(3-4):232-241. Epub 2018 Sep 21.

Department of Plastic, Reconstructive and Aesthetic Surgery, Knappschaftskrankenhaus Dortmund, Klinikum Westfalen, Dortmund, Germany.

Background: In response to tissue damage, angiogenesis is an extremely dynamic process that is finely regulated by signals from cells, the surrounding extracellular matrix (ECM), and derived mediators. As the only process, angiogenesis remains of decisive importance in the context of the entire wound healing process and is subject to constant change. The dissolution of the endothelial basement membrane, the migration of endothelial cells, and the development of new capillary vessels during wound healing depend not only on the cells and cytokines present, but also on the production and organization of ECM components in the immediate wound. Read More

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http://dx.doi.org/10.1159/000492410DOI Listing
March 2019
1 Read

Cell Sheet-Based Vascularized Myocardial Tissue Fabrication.

Eur Surg Res 2018 21;59(3-4):276-285. Epub 2018 Sep 21.

Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University, Tokyo,

Background: The development of regenerative medicine in recent years has been remarkable as tissue engineering technology and stem cell research have advanced. The ultimate goal of regenerative medicine is to fabricate human organs artificially. If fabricated organs can be transplanted medically, it will be the innovative treatment of diseases for which only donor organ transplantation is the definitive therapeutic method at present. Read More

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http://dx.doi.org/10.1159/000492416DOI Listing
March 2019
23 Reads

Platelet-Rich Plasma in Tissue Engineering: Hype and Hope.

Eur Surg Res 2018 21;59(3-4):265-275. Epub 2018 Sep 21.

IZKF Research Group Tissue Regeneration in Musculoskeletal Diseases, University Clinics Würzburg, Würzburg,

Background: Platelet-rich plasma (PRP) refers to an enriched platelet suspension in plasma. In addition to the clinical application of PRP in the context of various orthopedic diseases and beyond, PRP and platelet lysate (PL) have been in focus in the field of tissue engineering. In this review, we discuss the application of PRP as a cell culture supplement and as part of tissue engineering strategies, particularly emphasizing current hurdles and ambiguities regarding the efficacy of PRP in these approaches. Read More

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https://www.karger.com/Article/FullText/492415
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http://dx.doi.org/10.1159/000492415DOI Listing
March 2019
4 Reads

Vascularization, Regeneration and Tissue Engineering.

Eur Surg Res 2018 21;59(3-4):230-231. Epub 2018 Sep 21.

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https://www.karger.com/Article/FullText/492372
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http://dx.doi.org/10.1159/000492372DOI Listing
September 2018
17 Reads

Common Rodent Flap Models in Experimental Surgery.

Eur Surg Res 2018 21;59(3-4):255-264. Epub 2018 Sep 21.

Department of Plastic, Reconstructive and Aesthetic Surgery, Ospedale Regionale di Lugano, Ente Ospedaliero Cantonale, Lugano, Switzerland.

Background: Flap procedures are widely used in clinical reconstructive surgery. Since ische-mia-associated complications, e.g. Read More

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http://dx.doi.org/10.1159/000492414DOI Listing
March 2019
2 Reads

The Arteriovenous Loop: Engineering of Axially Vascularized Tissue.

Eur Surg Res 2018 21;59(3-4):286-299. Epub 2018 Sep 21.

Department of Plastic and Hand Surgery and Laboratory for Tissue Engineering and Regenerative Medicine, University Hospital of Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany.

Background: Most of the current treatment options for large-scale tissue defects represent a serious burden for the patients, are often not satisfying, and can be associated with significant side effects. Although major achievements have already been made in the field of tissue engineering, the clinical translation in case of extensive tissue defects is only in its early stages. The main challenge and reason for the failure of most tissue engineering approaches is the missing vascularization within large-scale transplants. Read More

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https://www.karger.com/Article/FullText/492417
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http://dx.doi.org/10.1159/000492417DOI Listing
March 2019
4 Reads

22nd Surgical Research Days.

Authors:

Eur Surg Res 2018 31;59(3-4):143-228. Epub 2018 Aug 31.

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http://dx.doi.org/10.1159/000492451DOI Listing
August 2018
1 Read

The MRI Sepsis Score: An Innovative Tool for the Evaluation of Septic Peritonitis in Mice Using 7-Tesla Small Animal MRI.

Eur Surg Res 2018 8;59(3-4):126-142. Epub 2018 Aug 8.

Department of General, Visceral, Thoracic and Vascular Surgery, Universitätsmedizin Greifswald, Greifswald, Germany.

Background: Magnetic resonance imaging (MRI) techniques are rarely used in the context of abdominal sepsis and in sepsis research. This study investigates the impact of MRI for monitoring septic peritonitis in an animal model (colon ascendens stent-induced peritonitis, CASP). The CASP model closely mimics that of human disease and is highly standardized. Read More

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https://www.karger.com/Article/FullText/490663
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http://dx.doi.org/10.1159/000490663DOI Listing
March 2019
12 Reads

Glycocalyx Degradation after Pulmonary Transplantation Surgery.

Eur Surg Res 2018 8;59(3-4):115-125. Epub 2018 Aug 8.

Department of Biochemistry & Molecular Biology, Faculty of Medicine, Complutense University of Madrid, Madrid, Spain.

Purpose: Ischaemia-reperfusion injury (IRI) is a main cause of morbidity after pulmonary resection surgery. The degradation of glycocalyx, a dynamic layer of macromolecules at the luminal surface of the endothelium, seems to participate in tissue dysfunction after IRI. Lidocaine has a proven anti-inflammatory activity in several tissues but its modulation of glycocalyx has not been investigated. Read More

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http://dx.doi.org/10.1159/000489492DOI Listing
March 2019
18 Reads

Healthcare IT Utilization and Penetration among Physicians: Novel IT Solutions in Healthcare - Use and Acceptance in Hospitals.

Eur Surg Res 2018 26;59(1-2):100-113. Epub 2018 Jul 26.

Department of Trauma Surgery, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.

Background: Healthcare IT (HIT) increasingly gains public attention and clinical daily relevance. A growing number of patients and physicians increasingly relies on IT services to monitor and support well-being and recovery both in their private and professional environment. This is assumed to develop rapidly in the upcoming years. Read More

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http://dx.doi.org/10.1159/000490241DOI Listing
November 2018
15 Reads

Glycine Protects the Liver from Reperfusion Injury following Pneumoperitoneum.

Eur Surg Res 2018 20;59(1-2):91-99. Epub 2018 Jul 20.

Department of General, Visceral and Transplant Surgery, University Hospital Heidelberg, Heidelberg, Germany.

Background: Experimental pneumoperitoneum induces ischemia/reperfusion injury (IRI) in the liver, most likely via Kupffer cell (KC)-dependent mechanisms. Glycine has been shown to ameliorate IRI in various animal models. Thus, this study was performed to assess the effects of glycine on the liver after pneumoperitoneum. Read More

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http://dx.doi.org/10.1159/000490309DOI Listing
November 2018
8 Reads

Influence of Telomere Length in Hepatocytes on Liver Regeneration after Partial Hepatectomy in Rats.

Eur Surg Res 2018 8;59(1-2):83-90. Epub 2018 Jun 8.

Department of General, Visceral and Transplant Surgery, Uniklinik RWTH Aachen, Aachen, Germany.

Background: The aim of this study was to investigate telomere length in hepatocytes as a biomarker for liver regeneration after partial hepatectomy (PH) in rats.

Materials And Methods: Sixty male Wistar rats underwent a 70% PH. One-month-old rats were assigned to group Y (n = 30) and 4-month-old rats were assigned to group O (n = 30). Read More

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http://dx.doi.org/10.1159/000489090DOI Listing
November 2018
17 Reads

Serial Assessment of Growth Factors Associated with Liver Regeneration in Patients Operated with Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy.

Eur Surg Res 2018 2;59(1-2):72-82. Epub 2018 May 2.

Division of Surgery, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

Background: There is limited knowledge about the mechanisms behind the unparalleled growth of the future liver remnant (FLR) linked to associating liver partition and portal vein ligation for staged hepatectomy (ALPPS). In this study, liver regenerative markers were examined in patients subjected to ALPPS.

Methods: Ten patients with colorectal liver metastases treated with neoadjuvant chemotherapy and ALPPS were included. Read More

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http://dx.doi.org/10.1159/000488078DOI Listing
November 2018
26 Reads

135th Congress of the German Society of Surgery (DGCH).

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Eur Surg Res 2018;59 Suppl 1:1-68. Epub 2018 Apr 12.

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http://dx.doi.org/10.1159/000488177DOI Listing
April 2018
3 Reads

Enhanced Vascular Biocompatibility and Remodeling of Decellularized and Secured Xenogeneic/Allogeneic Matrices in a Porcine Model.

Eur Surg Res 2018 5;59(1-2):58-71. Epub 2018 Apr 5.

Pôle de Chirurgie Expérimentale et Transplantation (CHEX), Institut de Recherche Expérimentale et Clinique, Secteur des Sciences de la Santé, Université Catholique de Louvain, Brussels, Belgium.

Background/purpose: Calcifications and absence of growth potential are the major drawbacks of glutaraldehyde-treated prosthesis. Decellularized and secured xeno-/allogeneic matrices were assessed in a preclinical porcine model for biocompatibility and vascular remodeling in comparison to glutaraldehyde-fixed bovine pericardium (GBP; control).

Methods: Native human (fascia lata, pericardium) and porcine tissues (peritoneum) were used and treated. Read More

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http://dx.doi.org/10.1159/000487591DOI Listing
November 2018
20 Reads

Hemostatic Efficacy and Safety of the Novel Medical Adhesive, MAR VIVO-107, in a Rabbit Liver Resection Model.

Eur Surg Res 2018 20;59(1-2):48-57. Epub 2018 Feb 20.

Institute for Laboratory Animal Science and Experimental Surgery, University Hospital RWTH Aachen, Aachen, Germany.

Background: Topical hemostatic agents are useful when hepatic hemorrhage is difficult to control. The aim of this study was to evaluate the hemostatic efficacy and safety of a biodegradable polyurethane-based adhesive, MAR VIVO-107 (MAR), in comparison with a clinically used fibrin glue.

Methods: Thirty female New Zealand white rabbits were randomly assigned to 3 study groups as follows: MAR (n = 10), fibrin glue (n = 10), and saline groups (n = 10). Read More

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http://dx.doi.org/10.1159/000481818DOI Listing
November 2018
20 Reads

Influence of Parathyroidectomy on Bone Metabolism and Bone Pain in Patients with Secondary Hyperparathyroidism.

Eur Surg Res 2018 23;59(1-2):35-47. Epub 2018 Jan 23.

Background: After parathyroidectomy (PTX), hungry bone syndrome leads to hypocalcemia due to bone remineralization. The aim of this pilot study was to analyze changes in markers of bone metabolism in patients with secondary hyperparathyroidism (sHPT) after PTX and to correlate these markers with bone pain measured with a validated questionnaire.

Materials And Methods: All patients who underwent PTX for sHPT between March 2010 and February 2012 at out institution were included in this prospective observational pilot study. Read More

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http://dx.doi.org/10.1159/000486172DOI Listing
November 2018
7 Reads

Quantification of Adipose Tissue and Muscle Mass Based on Computed Tomography Scans: Comparison of Eight Planimetric and Diametric Techniques Including a Step-By-Step Guide.

Eur Surg Res 2018 23;59(1-2):23-34. Epub 2018 Jan 23.

Department of Anesthesiology, University Hospital Munich (LMU), Munich, Germany.

Background: Recent scientific work proved that knowledge about body composition beyond the body mass index is essential. Both adipose tissue and muscular status are determining risk factors of morbidity and mortality. Analysis of single cross-sectional computed tomography (CT) images, acquired during routine care only to prevent additional radiation exposure, provide a detailed insight into the body composition of chronically and critically ill patients. Read More

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http://dx.doi.org/10.1159/000486173DOI Listing
November 2018
10 Reads

Impaired Value of 99m Tc-GSA Scintigraphy as an Independent Risk Factor for Posthepatectomy Liver Failure in Patients with Hepatocellular Carcinoma.

Eur Surg Res 2018 12;59(1-2):12-22. Epub 2018 Jan 12.

Background: Posthepatectomy liver failure (PHLF) was recently defined with the corresponding recommendations as follows: grade A, no change in clinical management; grade B, clinical management with noninvasive treatment; and grade C, clinical management with invasive treatment. In this study, we identified the risk factors for grade B and C PHLF in patients with hepatocellular carcinoma (HCC).

Methods: Of 339 HCC patients who underwent curative hepatic resection, 218 were included for analysis. Read More

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http://dx.doi.org/10.1159/000484044DOI Listing
November 2018
5 Reads

Electronic Nose in the Detection of Wound Infection Bacteria from Bacterial Cultures: A Proof-of-Principle Study.

Eur Surg Res 2018 10;59(1-2):1-11. Epub 2018 Jan 10.

Department of Surgery, School of Medicine, University of Tampere, Tampere, Finland.

Background: Soft tissue infections, including postoperative wound infections, result in a significant burden for modern society. Rapid diagnosis of wound infections is based on bacterial stains, cultures, and polymerase chain reaction assays, and the results are available earliest after several hours, but more often not until days after. Therefore, antibiotic treatment is often administered empirically without a specific diagnosis. Read More

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http://dx.doi.org/10.1159/000485461DOI Listing
November 2018
11 Reads

Cardiac Mesenchymal Stem Cells Proliferate Early in the Ischemic Heart.

Eur Surg Res 2017 26;58(5-6):341-353. Epub 2017 Oct 26.

Reference and Translation Center for Cardiac Stem Cell Therapy, Rostock University Medical Center, Rostock, Germany.

Background/purpose: Cardiac mesenchymal stem cells (MSCs) could stimulate cell-specific regenerative mechanisms after myocardial infarction (MI) depending on spatial origin, distribution, and niche regulation. We aimed at identifying and isolating tissue-specific cardiac MSCs that could contribute to regeneration.

Methods: Following permanent ligation of the left anterior descending coronary artery in rats (n = 16), early cardiac tissues and cardiac mononuclear cells (MNCs) were analyzed by immunohistology, confocal laser scanning microscopy, and flow cytometry, respectively. Read More

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http://dx.doi.org/10.1159/000480730DOI Listing
September 2018
22 Reads

Vascular Endothelial Dysfunction during Cardiac Surgery: On-Pump versus Off-Pump Coronary Surgery.

Eur Surg Res 2017 26;58(5-6):354-368. Epub 2017 Oct 26.

Department of Anaesthesiology, University Hospital of Munich (LMU), Munich, Germany.

Background: Cardiac surgery often causes ischemia and development of a systemic inflammatory response syndrome, which impairs vascular barrier function, normally maintained by the endothelial cell line and the endothelial glycocalyx (EG). The EG normally covers and protects healthy endothelial cells throughout the vasculature. The aim of the present study was to assess the disruption of the cellular part of the microvascular barrier by determining parameters of endothelial cell activation known to influence and reflect cell-cell junctional integrity. Read More

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http://dx.doi.org/10.1159/000480431DOI Listing
September 2018
20 Reads

Expression of VEGFR-2 during Liver Regeneration after Partial Hepatectomy in a Bioluminescence Mouse Model.

Eur Surg Res 2017 26;58(5-6):330-340. Epub 2017 Oct 26.

Department of General, Visceral and Transplantation Surgery, RWTH Aachen University Hospital, Aachen, Germany.

Background: Liver regeneration requires the formation of new blood vessels. Endothelial cell proliferation is stimulated by vascular endothelial growth factor (VEGF) and its receptor tyrosine kinase VEGFR-2. The aim of this study was to investigate VEGFR-2 expression in vivo during liver regeneration after partial hepatectomy (PHx). Read More

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http://dx.doi.org/10.1159/000479628DOI Listing
September 2018
18 Reads

The 52nd Congress of the European Society for Surgical Research. June 14-17, 2017, Amsterdam, The Netherlands: Abstracts.

Authors:

Eur Surg Res 2017 20;58 Suppl 2:1-69. Epub 2017 Sep 20.

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http://dx.doi.org/10.1159/000479831DOI Listing
September 2017
3 Reads

Early Discharge Programme on Hospital-at-Home Evaluation for Patients with Immediate Postoperative Course after Laparoscopic Colorectal Surgery.

Eur Surg Res 2017 9;58(5-6):263-273. Epub 2017 Aug 9.

Domiciliary Hospitalisation Unit, Hospital Universitario Marqués de Valdecilla, Santander, Spain.

Background: To audit the safety of the early hospital discharge care model offered by a Hospital-at-home (HAH) unit during early postoperative follow-up of these patients, and to determine whether this care model is more efficient compared to the traditional care model.

Methods: A prospective study of 50 patients included consecutively for 1 year in an early discharge programme after laparoscopic colorectal surgery was performed. As of day 3 after surgery, if the patient met the relevant inclusion criteria they were transferred to the HAH unit. Read More

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http://dx.doi.org/10.1159/000479004DOI Listing
September 2018
12 Reads

Defining Standards in Experimental Microsurgical Training: Recommendations of the European Society for Surgical Research (ESSR) and the International Society for Experimental Microsurgery (ISEM).

Eur Surg Res 2017 26;58(5-6):246-262. Epub 2017 Jul 26.

Department of Operative Techniques and Surgical Research, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.

Background: Expectations towards surgeons in modern surgical practice are extremely high with minimal complication rates and maximal patient safety as paramount objectives. Both of these aims are highly dependent on individual technical skills that require sustained, focused, and efficient training outside the clinical environment. At the same time, there is an increasing moral and ethical pressure to reduce the use of animals in research and training, which has fundamentally changed the practice of microsurgical training and research. Read More

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http://dx.doi.org/10.1159/000479005DOI Listing
September 2018
13 Reads

Intraoperative Real-Time Assessment of Liver Function with Near-Infrared Fluorescence Imaging.

Eur Surg Res 2017 17;58(5-6):235-245. Epub 2017 Jun 17.

Department of Gastroenterological Surgery II, Hokkaido University Graduate School of Medicine, Sapporo, Japan.

Background: Postoperative liver failure is a serious complication after major hepatectomy, and perioperative prediction of its incidence using current technology is still very difficult. Near-infrared (NIR) fluorescence imaging allows quantitative assessment of the fluorescent signal from indocyanine green (ICG) in regions of interest on the liver surface. This method might offer a new promising modality for evaluating regional liver reserve. Read More

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http://dx.doi.org/10.1159/000477347DOI Listing
September 2018
12 Reads

Skin Perfusion Changes within 12 h after Axillary Plexus Block.

Eur Surg Res 2017 1;58(5-6):227-234. Epub 2017 Jun 1.

Clinic for Hand, Plastic, Reconstructive and Burn Surgery, BG Unfallklinik Tübingen, Eberhard Karl University, Tübingen, Germany.

Background/purpose: An improvement of the blood flow would be beneficial in microvascular upper-extremity reconstruction and in digit replantation. In the present work, skin perfusion changes and their duration due to axillary plexus block were quantified.

Methods: The peripheral blood flow of the upper extremities in 20 patients undergoing trapeziectomy under axillary plexus block was analyzed. Read More

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http://dx.doi.org/10.1159/000475813DOI Listing
September 2018
27 Reads

In vitro Growth Pattern of Primary Human Osteoblasts on Calcium Phosphate- and Polymethylmethacrylate-Based Bone Cement.

Eur Surg Res 2017 12;58(5-6):216-226. Epub 2017 May 12.

Department of Orthopaedic Surgery, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.

Background/purpose: Polymethylmethacrylate (PMMA) and calcium phosphate (Ca-P) cements are widely used for arthroplasty surgery and augmentation of bone defects. However, aseptic implant loosening in absence of wear-induced osteolysis indicates an unfavourable interaction between the cement surface and human osteoblasts. Our underlying hypothesis is that cement surfaces directly modify cell viability, proliferation rate, and cell differentiation. Read More

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http://dx.doi.org/10.1159/000470839DOI Listing
September 2018
18 Reads

Argon Delays Initiation of Liver Regeneration after Partial Hepatectomy in Rats.

Eur Surg Res 2017 22;58(5-6):204-215. Epub 2017 Apr 22.

Department of General, Visceral, and Transplantation Surgery, University Hospital of RWTH Aachen, Aachen, Germany.

Background: The liver can heal up to restitutio ad integrum following damage resulting from various causes. Different studies have demonstrated the protective effect of argon on various cells and organs. To the best of our knowledge, the organ-protective effects of the noble gas argon on the liver have not yet been investigated, although argon appears to influence signal paths that are well-known mediators of liver regeneration. Read More

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http://dx.doi.org/10.1159/000466690DOI Listing
September 2018
16 Reads

The Aachen Minipig: Phenotype, Genotype, Hematological and Biochemical Characterization, and Comparison to the Göttingen Minipig.

Eur Surg Res 2017 22;58(5-6):193-203. Epub 2017 Apr 22.

Institute for Laboratory Animal Science and Experimental Surgery, University Hospital, RWTH Aachen University, Aachen, Germany.

Background: The pig is one of the most frequently used large animal models for biomedical research, especially in the field of translational research and surgical models. While standard livestock breeds are used in short-term and acute studies, minipig breeds are the preferred breeds in long-term and chronic studies due to their limited growth and body weight.

Objective: In consideration of the 3R principle (refinement, reduction, replacement) and the increasing demand, the aim of this study was to generate a new, robust, non-specific-pathogen-free minipig breed, the Aachen minipig. Read More

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http://dx.doi.org/10.1159/000471483DOI Listing
September 2018
11 Reads

High-Fat Diet in the Absence of Obesity Does Not Aggravate Surgically Induced Lymphoedema in Mice.

Eur Surg Res 2017 17;58(3-4):180-192. Epub 2017 Mar 17.

Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Zurich, Switzerland.

Background: Lymphoedema represents the cardinal manifestation of lymphatic dysfunction and is associated with expansion of the adipose tissue in the affected limb. In mice, high-fat diet (HFD)-induced obesity was associated with impaired collecting lymphatic vessel function, and adiposity aggravated surgery-induced lymphoedema in a mouse model. The aim of the current study was to investigate whether adiposity is necessary to impair lymphatic function or whether increased lipid exposure alone might be sufficient in a surgical lymphoedema model. Read More

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http://dx.doi.org/10.1159/000461579DOI Listing
November 2017
6 Reads