6,890 results match your criteria European Review for Medical and Pharmacological Sciences [Journal]


Infections in arthroscopy.

Eur Rev Med Pharmacol Sci 2019 Apr;23(2 Suppl):279-287

UOC Ortopedia e Traumatologia, Dipartimento di Geriatria, Neuroscienze ed Ortopedia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

Infection is a rare complication of arthroscopic procedures, with an overall incidence estimated in less than 1%. However, the actual prevalence may be higher as many cases may go unreported. Despite low incidence, early diagnosis is of outmost importance in order to avoid devastating consequences, such as arthrofibrosis. Read More

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http://dx.doi.org/10.26355/eurrev_201904_17502DOI Listing

Infection in orthopaedic oncology: crucial problem in modern reconstructive techniques.

Eur Rev Med Pharmacol Sci 2019 Apr;23(2 Suppl):271-278

Department of Orthopaedics and Orthopaedic Oncology, University of Padova, Padova, Italy.

Objective: Infection after orthopaedic oncology surgery is a relatively frequent complication. Infection rate ranges in the literature between 3.7% and 19. Read More

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http://www.europeanreview.org/article/17501
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http://dx.doi.org/10.26355/eurrev_201904_17501DOI Listing
April 2019
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Systemic antibiotic treatment of chronic osteomyelitis in adults.

Eur Rev Med Pharmacol Sci 2019 Apr;23(2 Suppl):258-270

Fondazione Policlinico A. Gemelli IRCCS, Rome, Italy, Istituto di Clinica delle Malattie Infettive, Università Cattolica S. Cuore, Rome, Italy.

Chronic osteomyelitis is a difficult to treat infection of the bone, which requires a combined medical and surgical approach and often persists intermittently for years, with relapses and failures. The optimal type, route of administration, and duration of antibiotic treatment remain controversial, and the emergence of multi-drug resistant organisms poses major therapeutic challenges. Identification of the causative agent and subsequent targeted antibiotic treatment has a major impact on patients' outcome. Read More

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http://www.europeanreview.org/article/17500
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http://dx.doi.org/10.26355/eurrev_201904_17500DOI Listing
April 2019
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Antifungal properties of silver coating on tumour endoprostheses: an in vitro study.

Eur Rev Med Pharmacol Sci 2019 Apr;23(2 Suppl):252-257

Department of Orthopaedics and Traumatology, Fondazione Policlinico Universitario A. Gemelli - IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.

Objective: We tested and quantified the in vitro effect of silver coating on preventing development of fungal biofilm over titanium, as found in some megaprosthesis used for musculoskeletal oncological reconstruction, to evaluate the antiseptic effect of this additional feature on this class of pathogens.

Materials And Methods: Different strains and species of Candida (C. albicans, C. Read More

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http://www.europeanreview.org/article/17499
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http://dx.doi.org/10.26355/eurrev_201904_17499DOI Listing
April 2019
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Clinical applications of Bioactive glass S53P4 in bone infections: a systematic review.

Eur Rev Med Pharmacol Sci 2019 Apr;23(2 Suppl):240-251

Orthopedic Department, San Gerardo Hospital, University of Milano-Bicocca, Monza, Italy.

Objective: Treatment of osteomyelitis, in of itself, is challenging but is further complicated by attendant bone infections. The management of bone infection, and bone rebuilding may be assisted by the use of bioactive glasses (BAGs) which have antimicrobial and osteo-stimulative proprieties. However, this clinical application and potential complications associated with BAGs (e. Read More

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http://www.europeanreview.org/article/17498
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http://dx.doi.org/10.26355/eurrev_201904_17498DOI Listing
April 2019
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Prevention of surgical site infections in orthopaedic surgery: a synthesis of current recommendations.

Eur Rev Med Pharmacol Sci 2019 Apr;23(2 Suppl):224-239

Department of Orthopaedics and Traumatology, Ospedale S. Giuseppe, Albano Laziale, Rome, Italy.

Despite adopted precautions, surgical site infection (SSI) rate in orthopaedic surgery and its consequences still remain a major problem. Worldwide, infection prevention and control in perioperative settings are considered of primary importance for every healthcare system. The management of perioperative infections carries a heavy psychological and financial burden, since patients who experience SSI have increased hospital length of stay, morbidity and mortality rates, and higher hospital costs. Read More

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http://dx.doi.org/10.26355/eurrev_201904_17497DOI Listing

Periprosthetic hip and knee infections: comparison of etiology, perioperative management and costs.

Eur Rev Med Pharmacol Sci 2019 Apr;23(2 Suppl):217-223

Department of Orthopaedic Surgery, University of Tor Vergata, Rome, Italy.

Objective: We compared two series of patients treated at our Hospital for periprosthetic hip and knee infections (PHI; PKI), in order to evaluate etiology, perioperative management (duration of spacer, antibiotic therapy, quality of life during the treatment), length of hospital stay, and costs.

Patients And Methods: We included in the study 32 patients with PHI and 30 patients with PKI. The average age of the patients was 74. Read More

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http://www.europeanreview.org/article/17496
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April 2019
2 Reads

Masquelet technique and osteomyelitis: innovations and literature review.

Eur Rev Med Pharmacol Sci 2019 Apr;23(2 Suppl):210-216

Department of Orthopaedics and Traumatology, Institute of Scientific Research, Children's Hospital Bambino Gesù, Rome, Italy.

Objective: Wide diaphyseal bone defects, above all those infected, encounter into Masquelet technique a suitable treatment. The two-step procedure allows the surgeon to eliminate the infected tissues and then to promote new bone formation. We analyzed the literature about the use of the induced membrane technique in osteomyelitis and the innovations recently suggested. Read More

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http://www.europeanreview.org/article/17495
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http://dx.doi.org/10.26355/eurrev_201904_17495DOI Listing
April 2019
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Spondylodiscitis: is really all well defined?

Eur Rev Med Pharmacol Sci 2019 Apr;23(2 Suppl):201-209

Infectious Diseases Unit, Department of Medical and Surgical Sciences, Sant'Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.

The term spondylodiscitis describes the infection of both the intervertebral disc space and the adjacent vertebrae. Pyogenic Vertebral Osteomyelitis (PVO) is more common in older patients (mean age 59-69 years) with a male preponderance (52-69%). Recent studies reported an alarming increase of incidence over the last 20 years, due to the increase of diagnostic sensibility, the increase of the average lifetime and to the consequent association of chronic disabling pathologies, of immunosuppression, of surgical or invasive procedure. Read More

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http://dx.doi.org/10.26355/eurrev_201904_17494DOI Listing

Infections in primary intramedullary nailing of open tibial fractures: a review article.

Eur Rev Med Pharmacol Sci 2019 Apr;23(2 Suppl):195-200

Department of Orthopaedics, Fondazione Policlinico Agostino Gemelli - IRCCS, Università Cattolica del Sacro Cuore di Roma, Rome, Italy.

Objective: Open fractures are insidious and life-threatening injuries. They frequently involve the leg. Our aim is to evaluate the efficacy of primary intramedullary nailing as a definitive treatment of open tibial fractures, compared to other fixation tools in terms of deep infections, healing fracture time and bony repair. Read More

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http://dx.doi.org/10.26355/eurrev_201904_17491DOI Listing

Epidemiological and clinical features of prosthetic joint infections caused by gram-negative bacteria.

Eur Rev Med Pharmacol Sci 2019 Apr;23(2 Suppl):187-194

Fondazione Policlinico A. Gemelli IRCCS - Rome, Italy.

Objective: To review the clinical literature focusing on epidemiology, clinical presentation and outcomes of prosthetic joint infections (PJIs) due to gram-negative bacteria (GNB) and to report the experience of a multicentric cohort.

Patients And Methods: A retrospective, observational, cohort study was performed in three Italian hospitals. All consecutive PJIs caused by GNB over a 12-year period (from May 2007 to March 2018) were enrolled. Read More

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http://dx.doi.org/10.26355/eurrev_201904_17490DOI Listing

Managing of musculoskeletal infections in children.

Eur Rev Med Pharmacol Sci 2019 Apr;23(2 Suppl):179-186

Department of Orthopaedics and Traumatology, Institute of Scientific Research, Children's Hospital Bambino Gesù, Rome, Italy.

Objective: Epidemiological features of musculoskeletal infections are in continuous evolution. The incidence of emerging causative pathogen is arising. Nevertheless, up to 50% of osteoarticular infections shows negative cultures. Read More

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http://dx.doi.org/10.26355/eurrev_201904_17488DOI Listing

Infection after spinal surgery and procedures.

Eur Rev Med Pharmacol Sci 2019 Apr;23(2 Suppl):173-178

Department of Orthopaedics and Trauma Surgery, University Campus Bio-Medico of Rome, Rome, Italy.

Postoperative infections after spinal surgery are a challenging issue, difficult to diagnose and treat, that requires prolonged medical therapy and even surgery. In this paper, we aim to review the current standards in the diagnosis and treatment of post-procedural Spondylodiscitis (SD). We performed a review of the available literature focusing on diagnostic and therapeutic standards of post-procedural SD, both after minimally invasive procedures and open surgery. Read More

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http://dx.doi.org/10.26355/eurrev_201904_17487DOI Listing
April 2019
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Trends in surgical management of the infected total ankle arthroplasty.

Eur Rev Med Pharmacol Sci 2019 Apr;23(2 Suppl):159-172

1st Orthopaedic and Traumatologic Clinic, IRCSS Istituto Ortopedico Rizzoli, Bologna, Italy.

Objective: We performed a systematic review of surgical treatment of the infected total ankle arthroplasty. The purpose of this investigation was to describe the current trends and to perform a critical analysis of the evidence reported in the existing literature.

Materials And Methods: A comprehensive search for all relevant articles published in English was conducted. Read More

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http://www.europeanreview.org/article/17486
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April 2019
3 Reads

Acute osteomyelitis and septic arthritis in children: a systematic review of systematic reviews.

Eur Rev Med Pharmacol Sci 2019 Apr;23(2 Suppl):145-158

Orthopaedics and Traumatology, Polytechnic University of Marche, Ancona, Italy.

Objective: Septic arthritis and osteomyelitis are rare in children, but they are difficult to treat and are associated with a high rate of sequelae. This paper addresses the main clinical issues related to septic arthritis and osteomyelitis by means of a systematic review of systematic reviews.

Materials And Methods: The major electronic databases were searched for systematic reviews/meta-analyses septic arthritis and osteomyelitis. Read More

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http://dx.doi.org/10.26355/eurrev_201904_17484DOI Listing
April 2019
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Arthrodesis of the ankle joint in septic osteoarthritis: six years long term outcomes in authors' personal experience.

Eur Rev Med Pharmacol Sci 2019 Apr;23(2 Suppl):139-144

Department of Biomedical and Dental Sciences and Morphofunctional Imaging; School of Orthopaedics and Traumatology; University of Messina, Messina, Italy.

Objective: Our goal was to evaluate the long-term clinical outcome of ankle arthrodesis, obtained by an extramedullary internal fixation with or without bone-grafting in the treatment of ankle' septic arthritis.

Patients And Methods: All patients treated with arthrodesis by extramedullary internal fixation for septic arthritis of the ankle joint between January 2011 and December 2016 in the same hospital were included in our retrospective study. Patients were followed-up for a minimum of two years. Read More

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http://dx.doi.org/10.26355/eurrev_201904_17483DOI Listing
April 2019
4 Reads

Advances in management of periprosthetic joint infections: an historical prospective study.

Eur Rev Med Pharmacol Sci 2019 Apr;23(2 Suppl):129-138

Department of Orthopedic and Trauma Surgery University Campus Bio-Medico of Rome, Rome, Italy.

Objective: The purpose of our study is to assess the incidence of prosthetic joint infection (PJI) after total Knee arthroplasty (TKA), total Hip arthroplasty (THA) and total Shoulder arthroplasty (TSA), to identify risk factors, determine the microbial spectrum and management's outcome.

Patients And Methods: A case-control, retrospective observational study was performed analyzing patients who developed a PJI after TKA, THA, and TSA from 2000 to 2017 at our hospital. The patient's risk profile was defined extracting from clinical records the following data: sex, age, BMI, type of implant, comorbidity, year of surgery, year of infection, previous intra-articular injection, microbial isolation, medical and surgical management outcome. Read More

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http://www.europeanreview.org/article/17482
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http://dx.doi.org/10.26355/eurrev_201904_17482DOI Listing
April 2019
2 Reads

A systematic review: characteristics, complications and treatment of spondylodiscitis.

Eur Rev Med Pharmacol Sci 2019 Apr;23(2 Suppl):117-128

Department Public Health, Experimental and Forensic Medicine, University of Pavia, Pavia, Italy.

Objective: This systematic review focuses on 5 key elements that may improve the decision-making process in spondylodiscitis: the infective agent, segmental instability, abscess development, neurological compromise and focus of infection.

Materials And Methods: We included 64 studies published between May 2012 and May 2017, that reported both a description of the discitis and comparative data regarding the disease and its complications.

Results: The majority of cases were caused by Staphylococcus spp (40. Read More

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http://www.europeanreview.org/article/17481
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http://dx.doi.org/10.26355/eurrev_201904_17481DOI Listing
April 2019
3 Reads

The identification of pathogens associated with periprosthetic joint infection in two-stage revision.

Eur Rev Med Pharmacol Sci 2019 Apr;23(2 Suppl):101-116

Orthopaedic Clinic, Department of Surgery and Translational Medicine, University of Florence, Florence, Italy.

Objective: Identification of periprosthetic joint infection (PJI)-related pathogens is crucial to decide what is the correct surgical strategies and the most secure timing to re-implant in case of two-stage revision. The purpose of the present study is to review the literature to identify the features of each exams which are used to identify the pathogens associated with PJI, to evaluate which are the most sensitive and specific and to set up an algorithm to decide when, in the field of two-stage revision, it's the ideal timing to re-implant.

Materials And Methods: We did a systematic review of the literature to look for peer-reviewed papers of any evidence level focusing on: (1) Microbiological and molecular exams for identification of PJI-related pathogens. Read More

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http://dx.doi.org/10.26355/eurrev_201904_17480DOI Listing

Minimally invasive surgery for the treatment of thoraco lumbar pyogenic spondylodiscitis: indications and outcomes.

Eur Rev Med Pharmacol Sci 2019 Apr;23(2 Suppl):94-100

Spine Division, Department of Orthopaedics and Traumatology, A. Gemelli University Hospital, Catholic University of the Sacred Heart, Rome, Italy.

Objective: Pyogenic spondylodiscitis (PS) is a non-specific infection affecting intervertebral disks and adjacent vertebral bodies. Once considered a rare condition in developed countries, the incidence of PS has been increasing alarmingly and still represents a challenge for clinicians and orthopedic surgeons. New minimally invasive techniques have been proposed but the proper indications for these different approaches remain controversial. Read More

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http://dx.doi.org/10.26355/eurrev_201904_17479DOI Listing

Contamination of revision procedures in patients with adverse tissues reaction to metal on metal implant.

Eur Rev Med Pharmacol Sci 2019 Apr;23(2 Suppl):86-93

Orthopaedic and Traumatology Department, Santo Spirito Hospital, Rome, Italy.

Objective: The aim of this study is to evaluate the incidence of infections in MoM total hip replacement revisions and to propose a therapeutic algorithm that can reduce the onset of this complication. Total hip arthroplasty is one of the most successful procedures performed annually in the world. As the population ages, the number of primary arthroplasty procedures performed each year is rising in conjunction with an increasing revision burden. Read More

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http://dx.doi.org/10.26355/eurrev_201904_17478DOI Listing

Post-arthroscopic septic arthritis of the knee. Analysis of the outcome after treatment in a case series and systematic literature review.

Eur Rev Med Pharmacol Sci 2019 Apr;23(2 Suppl):76-85

Department of Infectious Diseases, D. Cotugno Hospital, AORN Dei Colli, Naples, Italy.

Objective: The aim of this study was to review the characteristics of patients with septic arthritis after ACL reconstruction comparing our results with those deriving from the literature review.

Patients And Methods: Patients with suspected post arthroscopic septic arthritis of the knee occurring within 6 months after surgery were evaluated to be included in the investigation. Septic arthritis was defined by i) clinical evidence; ii) laboratory investigations; iii) synovial fluid leukocyte count of more than 2,5 x 104/μL or positive cultures obtained by synovial fluid aspirate. Read More

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http://dx.doi.org/10.26355/eurrev_201904_17477DOI Listing

Risk factors for failure of two-stage revision arthroplasty for infected hip prosthesis: review of the literature and single centre cohort analysis.

Eur Rev Med Pharmacol Sci 2019 Apr;23(2 Suppl):65-75

Department of Orthopaedics, Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario A. Gemelli - IRCCS, Rome, Italy.

Objective: Periprosthetic joint infections (PJI) are one of the most dangerous complications in hip surgery. "Two-stage" revision surgery is the treatment of choice. Nevertheless, 5-10% of failures are reported. Read More

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http://dx.doi.org/10.26355/eurrev_201904_17476DOI Listing

Clinical and prognostic features of prosthetic joint infections caused by Enterococcus spp.

Eur Rev Med Pharmacol Sci 2019 Apr;23(2 Suppl):59-64

Department of Infectious Diseases, AORN Dei Colli, Naples, Italy.

Objective: Pathogens colonizing the intestinal or urinary tract such as enterococci or Gram-negative bacilli can cause prosthetic joint infection (PJI).

Patients And Methods: PJI undergoing 2-stage exchange, referred to the Department of Infectious Diseases of the Cotugno Hospital of Naples and the Fondazione Policlinico Gemelli of Rome over a 7-year period (2009-2015) for Infectious Diseases (ID) consultation were included. Demographic data, detailed information about previous or underlying diseases, findings of the clinical examination, and results of laboratory investigations were analyzed. Read More

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http://www.europeanreview.org/article/17475
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http://dx.doi.org/10.26355/eurrev_201904_17475DOI Listing
April 2019
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Two-stage reimplantation in periprosthetic knee infection.

Eur Rev Med Pharmacol Sci 2019 Apr;23(2 Suppl):51-58

Multidisciplinary Department of Medical-Surgical and Dental Specialties, University of Campania "Luigi Vanvitelli", Naples, Italy

Objective: The increasing number of total knee arthroplasties performed yearly worldwide has resulted in a concomitant rise in bacterial infections. Two-stage reimplantation has been reported as the most successful method of treating periprosthetic knee infections. The purpose of this study was to describe all the phases of the two-stage reimplantation and to review the literature regarding the topic. Read More

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http://dx.doi.org/10.26355/eurrev_201904_17474DOI Listing

Serum biomarkers in the diagnosis of periprosthetic joint infection: consolidated evidence and recent developments.

Eur Rev Med Pharmacol Sci 2019 Apr;23(2 Suppl):43-50

Department of Basic Medical Sciences, Neuroscience and Sense Organs. Orthopaedic & Trauma Unit, School of Medicine, University of Bari "Aldo Moro", AOU Consorziale "Policlinico", Bari, Italy.

Periprosthetic Joint Infection (PJI) represents one of the leading causes of revision prosthetic surgery, accounting for 25% of failed Total Knee Replacement (TKR) and 15% of failed Total Hip Replacement (THR). The search for a biomarker that, together with clinical and radiological findings, could improve the management of such a kind of patients is currently a big challenge for orthopaedic surgeons. This review aims (1) to assess the accuracy and the limitations of the traditional (Serum Erythrocytes Sedimentation Rate, C-reactive Protein, Procalcitonin, Interleukin 6, Tumor Necrosis Factor alpha), (2) and to analyse the emerging serum biomarkers (Presepsin, Toll-like Receptor 2, soluble urokinase-type Plasminogen Activator Receptor, Chemokine Ligand 2 and Osteopontin) in the diagnosis of PJI. Read More

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http://dx.doi.org/10.26355/eurrev_201904_17473DOI Listing

Urinary tract infections after early removal of urinary catheter in total joint arthroplasty.

Eur Rev Med Pharmacol Sci 2019 Apr;23(2 Suppl):38-42

Department of Medical and Surgical Sciences, "Magna Graecia" University and "Mater Domini" University Hospital, Catanzaro, Italy.

Objective: Postoperative urine retention (POUR) is a well-known complication after total joint arthroplasty (TJA). POUR is most commonly managed with an indwelling catheter. However, indwelling catheters have been associated with a substantial risk of urinary tract infection (UTI). Read More

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http://dx.doi.org/10.26355/eurrev_201904_17472DOI Listing
April 2019
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Diabetic foot infections: a comprehensive overview.

Eur Rev Med Pharmacol Sci 2019 Apr;23(2 Suppl):26-37

Diabetes Care Unit, Endocrinology, University Hospital "A. Gemelli", Catholic University of the Sacred Heart, Rome, Italy.

Diabetic foot ulcers (DFUs), a micro-vascular complication, are associated with a substantial increase in morbidity and mortality. DFUs are a complicated mixture of neuropathy, peripheral arterial diseases, foot deformities, and infections. Foot infections are frequent and potentially devastating complications. Read More

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http://dx.doi.org/10.26355/eurrev_201904_17471DOI Listing
April 2019
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The use of custom-made antibiotic-loaded spacer in periprosthetic knee infection caused by XDR organism: case report and review of literature.

Eur Rev Med Pharmacol Sci 2019 Apr;23(2 Suppl):19-25

Department of Aging, Orthopedics and Rehabilitation; Institute of Orthopedics, Traumatology and Spine Surgery, Fondazione Policlinico Agostino Gemelli - IRCCS, Università Cattolica del Sacro Cuore di Roma, Rome, Italy.

Periprosthetic knee infection (PKI) remains one of the most challenging complications after total knee replacement, especially if caused by multidrug-resistant (MDR) or extensively drug-resistant (XDR) organisms. Multiple treatment options are available, such as long-term antibiotic suppression, surgical debridement with retention of the prosthesis, definitive resection arthroplasty, arthrodesis, one-stage or two-stage revision procedures, amputation. We present a rare case of a PKI caused by a XDR Klebsiella pneumoniae in a young patient who underwent a prosthetic reconstruction due to an osteosarcoma of the tibia. Read More

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http://www.europeanreview.org/article/17470
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http://dx.doi.org/10.26355/eurrev_201904_17470DOI Listing
April 2019
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Distal humeral septic non-union treated with debridement and vascularized fibular transfer: case report and review of the literature.

Eur Rev Med Pharmacol Sci 2019 Apr;23(2 Suppl):12-18

Orthopedic Department, San Gerardo Hospital, University of Milano-Bicocca, Monza, Italy.

Clinical management of a septic non-union of the distal humerus is challenging and is complicated by the diversity of potential treatments which are variably successful. We report a novel and very successful treatment of a 58-year-old man presenting an infected non-union of the right distal humerus, secondary to a closed fracture initially treated with two anatomic plates. After hardware removal, a two-stage reconstruction was performed. Read More

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http://dx.doi.org/10.26355/eurrev_201904_17469DOI Listing

Staged surgical management of the sequelae of neonatal septic hip arthritis: a case report and review of the literature.

Eur Rev Med Pharmacol Sci 2019 Apr;23(2 Suppl):6-11

Department of Orthopaedics and Paediatric Orthopaedics, and Department of Medical Informatics and Biostatistics; University of Medicine and Pharmacy, Cluj-Napoca, Romania.

Total necrosis of the femoral head is a common sequelae after septic hip arthritis in infancy. Septic hip dislocation may develop, with severe functional consequences on the growing child: limping and limb length discrepancy. We present our staged surgical treatment of Choi's type IV A sequelae of septic hip arthritis in a 2-year old boy. Read More

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http://www.europeanreview.org/article/17468
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http://dx.doi.org/10.26355/eurrev_201904_17468DOI Listing
April 2019
5 Reads

Cervical spondylodiscitis mimicking Pott's disease: a case report.

Eur Rev Med Pharmacol Sci 2019 Apr;23(2 Suppl):1-5

Department of Medical and Surgical Sciences, University Magna Græcia, Catanzaro, Italy.

Introduction: The leading cause of pyogenic vertebral osteomyelitis is Staphylococcus aureus, and its incidence is rising, particularly in the elderly. We report an unusual case of cervical spondylodiscitis and epidural abscess mimicking Pott's disease.

Case Report: A 67-year-old man was admitted to our institution with a 15-day history of neck pain radiating to the head, shoulders and left arm that was associated with weakness and paresthesia. Read More

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http://dx.doi.org/10.26355/eurrev_201904_17467DOI Listing
April 2019
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The effect of non-steroidal anti-inflammatory drugs on osteosarcoma cells.

Eur Rev Med Pharmacol Sci 2019 Mar;23(6):2681-2690

Department of Orthopaedic Surgery, Loma Linda University Medical Center, Loma Linda, CA, USA.

Objective: Osteosarcoma (OS), an aggressive malignancy, is the most common primary bone tumor in children. Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used to reduce pain and inflammation. NSAIDs have shown to be toxic to certain malignancies such as colorectal, breast, and pancreatic cancers, but are not well-studied in OS. Read More

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http://dx.doi.org/10.26355/eurrev_201903_17416DOI Listing
March 2019
1 Read

Sulodexide counteracts endothelial dysfunction induced by metabolic or non-metabolic stresses through activation of the autophagic program.

Eur Rev Med Pharmacol Sci 2019 Mar;23(6):2669-2680

Department of Radiotherapy, "Sapienza" University of Rome, Rome, Italy.

Objective: Endothelial dysfunction (ED) predisposes to venous thrombosis (VT) and post-thrombotic syndrome (PTS), a long-term VT-related complication. Sulodexide (SDX) is a highly purified glycosaminoglycan with antithrombotic, pro-fibrinolytic and anti-inflammatory activity used in the treatment of chronic venous disease (CVD), including patients with PTS. SDX has recently obtained clinical evidence in the "extension therapy" after initial-standard anticoagulant treatment for the secondary prevention of recurrent deep vein thrombosis (DVT). Read More

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http://dx.doi.org/10.26355/eurrev_201903_17415DOI Listing

Drug efficacies on bone mineral density and fracture rate for the treatment of postmenopausal osteoporosis: a network meta-analysis.

Eur Rev Med Pharmacol Sci 2019 Mar;23(6):2640-2668

Department of Orthopedics, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.

Objective: Globally, a great number of elderly suffer from osteoporosis, especially postmenopausal women. Osteoporosis results in low bone mineral density (BMD) and high risk of fragility fracture. However, there is no defined strategy to select the most suitable anti-osteoporotic drugs for osteoporosis patients. Read More

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http://dx.doi.org/10.26355/eurrev_201903_17414DOI Listing
March 2019
3 Reads

Combination of cells-based therapy with apelin-13 and hyperbaric oxygen efficiently promote neovascularization in ischemic animal model.

Eur Rev Med Pharmacol Sci 2019 Mar;23(6):2630-2639

Department of Vascular Surgery, General Hospital of Ningxia Medical University, Yinchuan, China.

Objective: Critical lower-limb ischemia (CLLI) is characterized by high morbidity and mortality. The aim of this study was to explore the effectiveness of the combination of cell therapy with apelin-13 and hyperbaric oxygen in CLLI animal model.

Materials And Methods: The experimental ischemic rats were divided into five groups, including negative control, bone marrow derived mononuclear cells (BM-MNCs), apelin-13, hyperbaric oxygen treatment (HBOT) and apelin-13 with HBOT group. Read More

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http://dx.doi.org/10.26355/eurrev_201903_17413DOI Listing

Sevoflurane induces temporary spatial working memory deficits and synaptic ultrastructure impairments in the hippocampus of neonatal rats.

Eur Rev Med Pharmacol Sci 2019 Mar;23(6):2620-2629

Department of Anesthesiology, the Second Hospital of Shandong University, Jinan, China.

Objective: Exposure to volatile anesthetics in neonatal rats could induce neurotoxicity, learning deficits and abnormal social behaviors. The aim of this study is to investigate the potential neurotoxicity induced by sevoflurane.

Materials And Methods: Postnatal day 7 (P7) Sprague-Dawley (SD) rats were continuously exposed to 2% sevoflurane plus 40% oxygen/air for 2 h. Read More

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http://dx.doi.org/10.26355/eurrev_201903_17412DOI Listing

Therapeutic effect of dexmedetomidine on intracerebral hemorrhage via regulating NLRP3.

Authors:
H-L Song S-B Zhang

Eur Rev Med Pharmacol Sci 2019 Mar;23(6):2612-2619

Department of Anesthesiology, Heze Municipal Hospital, Heze, China.

Objective: To investigate the protective effect of dexmedetomidine on intracerebral hemorrhage (ICH) mice and the underlying mechanism.

Materials And Methods: The in vivo ICH model was induced by the injection of autologous blood in C57BL/6 mice. Mice were randomly assigned into control group (no specific treatment) and treatment group (dexmedetomidine administration). Read More

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http://dx.doi.org/10.26355/eurrev_201903_17411DOI Listing
March 2019
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Modulating cAMP responsive element binding protein 1 attenuates functional and behavioural deficits in rat model of neuropathic pain.

Eur Rev Med Pharmacol Sci 2019 Mar;23(6):2602-2611

Department of Anesthesiology, First Affiliated Hospital of Anhui Medical University, Anhui, China.

Objective: Chronic neuropathic pain (NP) has become a worldwide public health problem. This study was aimed to establish graded NP model to investigate the effect of CREB1 on nerve repair and NP after peripheral nerve injury.

Materials And Methods: Based on NP model, we measured the 50% paw withdrawal threshold (PWT) of rat hind paws and sciatic functional index (SFI). Read More

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http://dx.doi.org/10.26355/eurrev_201903_17410DOI Listing

Effects of epidural infusion of morphine combined with small-dose naloxone on gastrointestinal interstitial cells of Cajal in rabbits.

Authors:
H Yang H Luo Y-H Li

Eur Rev Med Pharmacol Sci 2019 Mar;23(6):2596-2601

Department of Anesthesiology, First Affiliated Hospital of Anhui Medical University, Anhui, China.

Objective: To study the effect of epidural infusion of morphine combined with small-dose naloxone on gastrointestinal interstitial cells of Cajal (ICC) in rabbits.

Materials And Methods: A total of 80 healthy New Zealand rabbits were selected as objects of study, and divided into normal saline control group (Group NS, n=20), morphine group (Group M, n=20), naloxone group (Group N, n=20), and morphine + naloxone group (Group NM, n=20). Rabbits in four the groups received epidural catheterization for continuous drug infusion for 7 d, and epidural analgesia pump was connected. Read More

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http://dx.doi.org/10.26355/eurrev_201903_17409DOI Listing

Effects of α-lipoic acid on chronic cerebrovascular hypoperfusion in an animal model of vascular dementia.

Eur Rev Med Pharmacol Sci 2019 Mar;23(6):2587-2595

Brain Research Institute, Wonkwang University School of Medicine, Iksan, Jeonbuk, Korea.

Objective: Given the aging population, the treatment of vascular dementia (VaD) is becoming increasingly important. The antioxidant α-lipoic acid (α-LA) protects against neurodegeneration in VaD, but the underlying mechanisms remain unclear. Hence, we aimed to identify the effects of α-LA on cognitive function following chronic cerebrovascular hypoperfusion in a VaD animal model. Read More

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http://www.europeanreview.org/article/17408
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http://dx.doi.org/10.26355/eurrev_201903_17408DOI Listing
March 2019
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Developments on treatment of Chagas disease - from discovery to current times.

Eur Rev Med Pharmacol Sci 2019 Mar;23(6):2576-2586

Universidade Federal Fluminense, Instituto de Química, Departamento de Química Orgânica, Programa de Pós-Graduação em Química, Rio de Janeiro, Brazil.

Objective: This work aims to collect publications of available drugs for reposition and new substance development against the Chagas disease, since they represent the beginning of a path for new discoveries of viable alternatives to improve the prognosis of millions of patients around the world.

Patients And Methods: An extended research on English and Portuguese-language literature in the Scientific Electronic Library Online - Scielo, SciFinder and PubMed - database was made. The bibliography was screened using the keywords "Chagas Disease" and "Treatment". Read More

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http://www.europeanreview.org/article/17407
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http://dx.doi.org/10.26355/eurrev_201903_17407DOI Listing
March 2019
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The association between the lymphocyte-to-monocyte ratio and coronary artery disease severity in patients with stable coronary artery disease.

Eur Rev Med Pharmacol Sci 2019 Mar;23(6):2570-2575

Department of Cardiology, Private Yucelen Hospital, Mugla, Turkey.

Objective: Inflammation plays an important role in the pathogenesis of atherosclerosis. The lymphocyte-to-monocyte ratio (LMR) may reflect a systemic inflammatory status. We investigated the association between the LMR and coronary artery disease (CAD) in patients with stable angina pectoris. Read More

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http://dx.doi.org/10.26355/eurrev_201903_17406DOI Listing
March 2019
2 Reads

Free light chains a novel biomarker of cardiovascular disease. A pilot study.

Eur Rev Med Pharmacol Sci 2019 Mar;23(6):2563-2569

Area Diagnostica di Laboratorio, Fondazione Policlinico Universitario A. Gemelli - IRCCS, Rome, Italy.

Objective: Atherosclerosis and ischemic heart disease (IHD) are the major cause of morbidity and mortality but their inflammatory pathogenesis is still unclear. In this scenario, the role of serum free light chains (sFLC) has never been fully evaluated. The aim of the present study is to assess the clinical and pathogenetic role of sFLC in patients with IHD and to propose their use as a new biomarker for cardiovascular disease. Read More

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http://dx.doi.org/10.26355/eurrev_201903_17405DOI Listing

MiR-34a regulates cell apoptosis after myocardial infarction in rats through the Wnt/β-catenin signaling pathway.

Eur Rev Med Pharmacol Sci 2019 Mar;23(6):2555-2562

Department of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.

Objective: To explore the molecular mechanism of micro ribonucleic acid-34a (miR-34a) in promoting the apoptosis of myocardial cells in the rat model of myocardial infarction (MI).

Materials And Methods: Sprague-Dawley (SD) rats were ligated with a left anterior descending branch to construct the MI model. The rats were randomly divided into four groups: sham operation group (Sham group), MI group, MI + miR-34a inhibitor group (MI + miR-34a antagomir group) and MI + miR-34a inhibitor negative control group (MI + antagomir NC group). Read More

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http://dx.doi.org/10.26355/eurrev_201903_17404DOI Listing

MiRNA-210 induces the apoptosis of neuronal cells of rats with cerebral ischemia through activating HIF-1α-VEGF pathway.

Eur Rev Med Pharmacol Sci 2019 Mar;23(6):2548-2554

School of Life Sciences, Lanzhou University, Lanzhou, Gansu, China.

Objective: This study aims to explore the expression of micro-ribonucleic acid (miRNA)-210 in the cerebral cortex of rat model with global cerebral ischemia, and determine its function on the regulation of the apoptosis of neuronal cells.

Materials And Methods: Rat models of global cerebral ischemia were established in vitro. Rats were euthanized at 24 h after reperfusion and the cerebral cortex was collected. Read More

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http://dx.doi.org/10.26355/eurrev_201903_17403DOI Listing

Elevated hepatic MDR3/ABCB4 is directly mediated by MiR-378a-5p in human obstructive cholestasis.

Eur Rev Med Pharmacol Sci 2019 Mar;23(6):2539-2547

Departments of Gastroenterology, Southwest Hospital, Army Military Medical University, Chongqing, China.

Objective: The function of MDR3 is important in bile acid transport. The miRNAs can suppress the expression of gene through combining mRNA of target gene. The regulation about MDR3 mediated by FXR or PPARα in cholestasis is clear, but the mechanism through miRNA is hardly reported. Read More

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http://dx.doi.org/10.26355/eurrev_201903_17402DOI Listing

Colonoscopy quality assessment and accuracy: analysis of the influencing factors and surgical sequelae on 216 colonoscopies.

Eur Rev Med Pharmacol Sci 2019 Mar;23(6):2532-2538

Digestive Surgery Unit of the Fondazione Policlinico "A. Gemelli" IRCCS, Catholic University of Sacred Heart, Rome, Italy.

Objective: Colonoscopy is recognized as the primary screening test for colorectal cancer. However, its inaccuracy in identifying the exact tumor localization is still high. As a consequence, repeated colonoscopies and changes in the surgical management have been reported. Read More

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http://www.europeanreview.org/article/17401
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http://dx.doi.org/10.26355/eurrev_201903_17401DOI Listing
March 2019
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Effects of MiR-26a on respiratory distress syndrome in neonatal rats via the wnt/β-catenin signaling pathway.

Authors:
H-F Li J-Y Liu

Eur Rev Med Pharmacol Sci 2019 Mar;23(6):2525-2531

Department of Gynaecology and Obstetrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Objective:   Micro ribonucleic acids (miRNAs) are crucial to post-transcriptional regulation of the gene expression. Whether miR-26a affects respiratory distress syndrome (RDS) in neonatal rats through the Wnt/β-catenin signaling pathway was investigated in this study.

Patients And Methods: The neonatal rat model of RDS was established, and the expressions of miR-26a and glycogen synthase kinase-3β (GSK-3β) in RDS in neonatal rats and their correlation were analyzed. Read More

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http://dx.doi.org/10.26355/eurrev_201903_17400DOI Listing

Developing and cross-validation of new equations to estimate fat mass in Italian population.

Eur Rev Med Pharmacol Sci 2019 Mar;23(6):2513-2524

Department of Biomedicine and Prevention, Section of Clinical Nutrition and Nutrigenomic, University of Tor Vergata, Rome, Italy.

Objective: Obesity is a global burden that involves more than 500 million people. The objective of this work is to develop and cross-validate the new sex-specific equations to estimate fat mass, based on anthropometric parameters and to compare with other equations.

Patients And Methods: We evaluated 38762 subjects by dual-energy X-ray absorptiometry (DXA) and enrolled 1434 women and 640 men, aged between 18 and 65 years. Read More

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http://dx.doi.org/10.26355/eurrev_201903_17399DOI Listing
March 2019
1 Read