6,691 results match your criteria European Review for Medical and Pharmacological Sciences [Journal]


Taste, olfactory and texture related genes and food choices: implications on health status.

Eur Rev Med Pharmacol Sci 2019 Feb;23(3):1305-1321

MAGI Euregio, Nonprofit Genetic Testing Laboratory, Bolzano, Italy.

Objective: The food choices are due to a mixture of sensory signals including gustatory, olfactory, and texture sensations. The aim of this quality review was to update data about studies concerning genetics of taste, olfactory and texture receptors and their influence on the health status in humans.

Materials And Methods: An electronic search was conducted in MEDLINE, Pubmed database and Scopus, for articles published in English until December 2018. Read More

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http://www.europeanreview.org/article/17026
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http://dx.doi.org/10.26355/eurrev_201902_17026DOI Listing
February 2019
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Mendelian obesity, molecular pathways and pharmacological therapies: a review.

Eur Rev Med Pharmacol Sci 2019 Feb;23(3):1357-1378

MAGI'S Lab, Genetic Testing Laboratory, Rovereto (TN), Italy.

Objective: In this qualitative review we analyze the major pathways and mechanisms involved in the onset of genetically-determined obesity (Mendelian obesity), identifying possible pharmacological treatments and trials.

Materials And Methods: We searched PubMed with the keywords (obesity[Title/Abstract]) AND mutation[Title/Abstract], and OMIM with the keyword "obesity". In both cases, we selected non-syndromic Mendelian obesity. Read More

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http://dx.doi.org/10.26355/eurrev_201902_17031DOI Listing
February 2019

Effect of sevoflurane on hepatic ischemia-reperfusion injury in rats via JAK2-STAT3 pathway.

Authors:
L-J Sima X-W Ma

Eur Rev Med Pharmacol Sci 2019 Feb;23(3):1350-1356

Department of Anesthesiology, The First Affiliated Hospital, Henan University of Science and Technology, Luoyang City, Henan Province, China.

Objective: To investigate the effect of sevoflurane on hepatic ischemia-reperfusion injury in rats via janus kinase 2/signal transducer and activator of transcription 3 (JAK2-STAT3) pathway.

Materials And Methods: Forty healthy male Sprague-Dawley (SD) rats were randomly divided into sham group (n=10), model group (HIRI group, n=10), sevoflurane intervention group (SF group, n=10), and sevoflurane combined with AG490 intervention group (AG490 group, n=10). Liver and serum samples were collected after reperfusion for 6 h. Read More

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http://dx.doi.org/10.26355/eurrev_201902_17030DOI Listing
February 2019

Effect of isoflurane on myocardial ischemia-reperfusion injury through the p38 MAPK signaling pathway.

Eur Rev Med Pharmacol Sci 2019 Feb;23(3):1342-1349

Department of Anesthesiology, Beijing Jishuitan Hospital, Beijing, China.

Objective: To investigate the effect of isoflurane on myocardial ischemia-reperfusion injury through the p38 mitogen-activated protein kinase (MAPK) signaling pathway.

Materials And Methods: A total of 36 specific-pathogen-free (SPF) Sprague-Dawley rats were randomly divided into sham group (n=12), model group (n=12) and isoflurane group (n=12). In model group and isoflurane group, the myocardial ischemia-reperfusion injury model was established via the ligation of left anterior descending coronary artery (ischemia for 30 min and reperfusion for 3 h). Read More

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http://dx.doi.org/10.26355/eurrev_201902_17029DOI Listing
February 2019

Influence of roflumilast on sepsis mice through the JAK/STAT signaling pathway.

Eur Rev Med Pharmacol Sci 2019 Feb;23(3):1335-1341

Department of Infectious Diseases, the First Affiliated Hospital of Anhui Medical University, Hefei, China.

Objective: The aim of this study was to explore the influence of roflumilast on sepsis mice through the Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway.

Materials And Methods: A total of 36 Sprague-Dawley mice were randomly divided into normal group (n=12), model group (n=12) and roflumilast group (n=12). Mice in the normal group were fed normally. Read More

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http://dx.doi.org/10.26355/eurrev_201902_17028DOI Listing
February 2019

Role of phase angle in the evaluation of effect of an immuno-enhanced formula in post-surgical cancer patients: a randomized clinical trial.

Eur Rev Med Pharmacol Sci 2019 Feb;23(3):1322-1334

Section of Clinical Nutrition and Nutrigenomic, Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy.

Objective: Neoplastic disease is frequently associated with poor nutritional status or severe malnutrition. Diet and nutritional intervention are becoming increasingly important for prognosis and quality of life in cancer patients. Accessible and repeatable tools for assessing nutritional status with body composition techniques seems to be fundamental. Read More

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http://www.europeanreview.org/article/17027
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http://dx.doi.org/10.26355/eurrev_201902_17027DOI Listing
February 2019
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Influence of lncRNA MALAT1 on septic lung injury in mice through p38 MAPK/p65 NF-κB pathway.

Eur Rev Med Pharmacol Sci 2019 Feb;23(3):1296-1304

Department of Obstetrics and Gynecology, Xiamen Maternal and Child Health Hospital, Xiamen, China.

Objective: To investigate the influence of long non-coding ribonucleic acid (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) on septic lung injury in mice and its mechanism, so as to provide references for the clinical prevention and treatment of septic lung injury in the future.

Materials And Methods: A total of 60 male C57 mice were randomly divided into Control group (n=20), lipopolysaccharide (LPS) group (n=20), and LPS+MALAT1 siRNA group (n=20) using a random number table. The mouse model of septic lung injury was established via intraperitoneal injection of LPS (10 mg/kg), and the MALAT1 knockdown model was established via tail intravenous injection of MALAT1 siRNA. Read More

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http://dx.doi.org/10.26355/eurrev_201902_17025DOI Listing
February 2019

The effect of intestinal flora on the neural development of severe hyperbilirubinemia neonates.

Eur Rev Med Pharmacol Sci 2019 Feb;23(3):1291-1295

Department of Pediatric, Dezhou People's Hospital, Dezhou, P.R. China.

Objective: To investigate the effect of intestinal flora on the neural development of severe hyperbilirubinemia neonates.

Patients And Methods: The clinical data of 108 severe hyperbilirubinemia neonates admitted to the Dezhou People's Hospital from January 2015 through January 2018 were analyzed, and all newborns had a serum total bilirubin level > 342 μmol/L. Based on whether they suffered from neural development abnormalities, the neonatal patients were divided into the neural abnormality group (n=52) and the non-neural abnormality group (n=56). Read More

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http://dx.doi.org/10.26355/eurrev_201902_17024DOI Listing
February 2019

Cellular mechanism of Tβ4 intervention in liver fibrosis by regulating NF-κB signaling pathway.

Eur Rev Med Pharmacol Sci 2019 Feb;23(3):1279-1290

Department of Clinical Medicine, Guizhou Medical University, Guiyang, P. R. China.

Objective: To investigate the inhibitory effect of thymosin-β4 (Tβ4) on the activation of the human hepatic stellate cell line (HSC-LX2) induced by interleukin (IL)-1β.

Materials And Methods: There were 5 groups in this study, i.e. Read More

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http://dx.doi.org/10.26355/eurrev_201902_17023DOI Listing
February 2019

The role of the hospital environment in the healthcare-associated infections: a general review of the literature.

Eur Rev Med Pharmacol Sci 2019 Feb;23(3):1266-1278

Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.

Healthcare-associated infections (HAIs) are one of the most relevant public health problems worldwide. The role of the hospital environment as a reservoir of pathogens causing HAIs is still debated. These pathogens are common in several hospital environments, where they are able to persist from hours to months and their circulation is favored by healthcare workers (HCWs). Read More

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http://dx.doi.org/10.26355/eurrev_201902_17020DOI Listing
February 2019

Hybrid procedures and femoral endarterectomy in diabetic patients.

Eur Rev Med Pharmacol Sci 2019 Feb;23(3):1257-1265

Vascular Surgery Unit, Azienda Ospedaliero Universitaria Pisana, Pisa, Italy.

Objective: The aim of the study is to evaluate the safety and effectiveness of common femoral endarterectomy (CFE) in critical limb ischemia (CLI) associated with proximal and distal endovascular (EV) revascularization in diabetic (type 1 and type 2) and non-diabetic patients.

Patients And Methods: We analyzed patients from January 2008 to December 2011 who underwent one-staged hybrid procedures. Patients were divided into three groups: group 1 = EV reconstruction proximal to the CFE, group 2 = EV procedures distal to the CFE, group 3 = both proximal and distal EV procedures. Read More

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http://dx.doi.org/10.26355/eurrev_201902_17019DOI Listing
February 2019

MicroRNA-770-5p is involved in the development of diabetic nephropathy through regulating podocyte apoptosis by targeting TP53 regulated inhibitor of apoptosis 1.

Eur Rev Med Pharmacol Sci 2019 Feb;23(3):1248-1256

Department of Nephrology, The Third Clinical College of Wenzhou Medical University, Wenzhou People's Hospital, Wenzhou, Zhejiang Province, China.

Objective: Diabetic nephropathy (DN) is a major diabetic micro-vascular complication, and podocyte apoptosis induced by high glucose (HG) is a typical early feature of DN. Studies have shown that microRNAs (miRNAs) play a crucial role in the pathogenesis of DN. The purpose of the current study was to explore the role and molecular mechanism of miR-770-5p in podocyte apoptosis in DN. Read More

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http://dx.doi.org/10.26355/eurrev_201902_17018DOI Listing
February 2019

Preparedness for chemical crisis situations: experiences from European medical response exercises.

Eur Rev Med Pharmacol Sci 2019 Feb;23(3):1239-1247

Comprehensive Defence Division, Norwegian Defence Research Establishment, Kjeller, Norway.

Objective: This study investigated how European first responders and hospital personnel, along with CBRN experts, approach an overwhelming surge situation after a chemical incident. Surge capacity and capability bottlenecks were discussed.

Materials And Methods: Two chemical warfare agent (CWA) scenarios were developed: in the first, a nerve agent was released indoors; in the second, there was an outdoor explosion containing a blister agent. Read More

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http://dx.doi.org/10.26355/eurrev_201902_17017DOI Listing
February 2019

Diet quality and eating patterns in euthymic bipolar patients.

Eur Rev Med Pharmacol Sci 2019 Feb;23(3):1221-1238

Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznań, Poland.

Objective: As mood disorders and obesity are interrelated, and both are linked to increased morbidity and mortality, risk factors for obesity should be identified and closely monitored in patients with bipolar disorder (BD). The aim of this study was to determine the diet quality of BD patients and to investigate its putative associations with comorbid obesity and disorders of carbohydrate metabolism, as well as the relationship between diet and clinical features of BD.

Patients And Methods: Eating patterns in 113 euthymic BD patients and 160 healthy control subjects were assessed using data obtained from a food frequency questionnaire. Read More

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http://dx.doi.org/10.26355/eurrev_201902_17016DOI Listing
February 2019

Bone marrow stem cells derived exosomes improve osteoporosis by promoting osteoblast proliferation and inhibiting cell apoptosis.

Eur Rev Med Pharmacol Sci 2019 Feb;23(3):1214-1220

Department of Orthopedic, Liuzhou Worker's Hospital, Liuzhou, China.

Objective: The aim of this study was to investigate whether bone marrow stem cells (MSCs) derived exosomes in rats could promote osteoblast proliferation and improve osteoporosis via inhibiting cell apoptosis.

Materials And Methods: MSCs in rats were isolated and cultured, followed by the identification of surface antigens via flow cytometry. The differentiation of MSCs was detected by alizarin red staining and oil red staining. Read More

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http://dx.doi.org/10.26355/eurrev_201902_17014DOI Listing
February 2019

Upregulation of miR-504-3p is associated with favorable prognosis of acute myeloid leukemia and may serve as a tumor suppressor by targeting MTHFD2.

Eur Rev Med Pharmacol Sci 2019 Feb;23(3):1203-1213

Department of Hematology, Jining No. 1 People's Hospital, Jining City, Shandong Province, China.

Objective: Deregulated expression of miRNAs contributes to the development of acute myeloid leukemia (AML). miR-504-3p, one of these miRNAs, has been found have upregulated expression in various human malignancies. Our present study aimed to detect the expression of miR-504-3p and its biological effect in AML. Read More

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http://dx.doi.org/10.26355/eurrev_201902_17013DOI Listing
February 2019

Correlation between IL-7 genomic protein methylation level and acute myeloid leukemia.

Authors:
Z-H Li Y Liu S-Y Gao

Eur Rev Med Pharmacol Sci 2019 Feb;23(3):1196-1202

Medicine Experimental Training Center, Weifang Medical University, Weifang, P. R. China.

Objective: To detect Interleukin-7 (IL-7) gene methylation status and transcription level in leukemia cells of peripheral blood of patients with Acute Myelocytic Leukemia (AML) and in the cell lines (HL-60, HL-60/ADM, SKM-1) of AML and myelodysplastic syndrome (MDS), and explore its relationship with the pathogenesis of AML.

Patients And Methods: A total of 55 AML patients (AML group) and 30 healthy adults (Healthy group) from June 2015 to June 2018 were enrolled in this study. The genomic DNA of leukemia cells in peripheral blood was extracted. Read More

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http://dx.doi.org/10.26355/eurrev_201902_17012DOI Listing
February 2019

Attenuating the abnormally high expression of AEBP1 suppresses the pathogenesis of childhood acute lymphoblastic leukemia via p53-dependent signaling pathway.

Eur Rev Med Pharmacol Sci 2019 Feb;23(3):1184-1195

Department of Pediatrics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Objective: This study aimed to explore the candidate genes and their potential mechanism in childhood acute lymphoblastic leukemia (cALL).

Materials And Methods: Differentially expressed genes (DEGs) were screened from GSE67684 (treatment), GSE28460 (relapse), and GSE60926 (relapse). The expression of AEBP1 at different stages of cALL was analyzed followed by functional enrichment analysis of its co-expressed genes. Read More

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http://dx.doi.org/10.26355/eurrev_201902_17011DOI Listing
February 2019

Correlations of mouse lymphoma xenografts with the expressions of MMP-9 and Bcl-2.

Eur Rev Med Pharmacol Sci 2019 Feb;23(3):1176-1183

Department of Hematology, Qingdao Center Hospital, Qingdao, Shandong, P.R. China.

Objective: To establish a mouse lymphoma xenograft model so as to investigate the correlation between the expression of matrix metallopeptidase-9 (MMP-9) and that of B-cell lymphoma 2 (Bcl-2) in lymphomas.

Materials And Methods: Diffuse large Bcl (DLBCL) cells were cultured, and a mouse lymphoma xenograft model was established via the subcutaneous injection. Mouse lymphoma tissues were extracted, and the expressions of MMP-9 and Bcl-2 messenger ribonucleic acids (mRNAs) in the xenograft tumor were detected using Real-time polymerase chain reaction (PCR). Read More

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http://dx.doi.org/10.26355/eurrev_201902_17010DOI Listing
February 2019

Impact of malnutrition on survival and infections among pediatric patients with cancer: a retrospective study.

Eur Rev Med Pharmacol Sci 2019 Jan;23(3):1165-1175

Dipartimento di Scienze della Salute della Donna e del Bambino, UOSA di Oncologia Pediatrica, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

Objective: Recognizing and managing malnutrition among hospitalized children affected by cancer is a rising need. Awareness and consideration of malnutrition among clinicians are still largely insufficient. This can principally be explained by the lack of consciousness and the shortage of easy and objective tools to identify malnutrition status. Read More

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http://dx.doi.org/10.26355/eurrev_201901_17009DOI Listing
January 2019

Breast cancer in women living with HIV.

Eur Rev Med Pharmacol Sci 2019 Feb;23(3):1158-1164

Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.

With the introduction of HAART, the life expectancy of the patients infected with HIV almost approached that of the general population. The incidence of certain HIV-Associated cancers as Kaposi Sarcoma (KS) and Non-Hodgkin Lymphoma (NHL) decreased, while an increase in Non-AIDS-Defining cancers (NADCs) has been documented. HIV infection is a risk factor for numerous cancers in PLWH. Read More

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http://dx.doi.org/10.26355/eurrev_201902_17007DOI Listing
February 2019

Effect of miR-34a on resistance to sunitinib in breast cancer by regulating the Wnt/β-catenin signaling pathway.

Eur Rev Med Pharmacol Sci 2019 Feb;23(3):1151-1157

Department of Breast Surgery, Yantaishan Hospital, Yantai, China.

Objective: The aim of this study was to investigate the influence of micro ribonucleic acid (miR)-34a on resistance to sunitinib in breast cancer, and to explore its possible underlying mechanism.

Materials And Methods: Breast cancer MCF-7 cells were transfected with miR-34a inhibitor or mimics to downregulate or upregulate the expression of miR-34a. Then, the transfected cells were treated with sunitinib. Read More

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http://dx.doi.org/10.26355/eurrev_201902_17006DOI Listing
February 2019

MiR-202-3p functions as a tumor suppressor and reduces cell migration and invasion in papillary thyroid carcinoma.

Eur Rev Med Pharmacol Sci 2019 Feb;23(3):1145-1150

Department of General surgery, Affiliated Haian Hospital of Nantong University, Haian County of Nantong City, China.

Objective: MicroRNAs (miRNAs) are recently identified as key regulators of tumor development and progression. MiR-202-3p functions as tumor suppressor in some cancer types. The aim of the study is to determine its expression pattern and explore the functions underlying the mechanism of miR-202-3p in papillary thyroid carcinoma (PTC). Read More

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http://dx.doi.org/10.26355/eurrev_201902_17005DOI Listing
February 2019

SP1-induced upregulation of long noncoding RNA LINC00313 contributes to papillary thyroid cancer progression via the miR-422a.

Eur Rev Med Pharmacol Sci 2019 Feb;23(3):1134-1144

Department of Head and Neck Surgery, National Cancer Center/ National Clinical Research Center for Cancer/ Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union.

Objective: Long noncoding RNA LINC00313 (LINC00313) has been reported to be dysregulated in several tumors, including papillary thyroid carcinoma (PTC). Our present study aimed to further explore the potential mechanism of LINC00313 in the progression of papillary thyroid carcinoma (PTC).

Patients And Methods: RT-PCR was performed to detect the expression of LINC00313 in both PTC tissues and cell lines. Read More

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http://www.europeanreview.org/article/17004
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http://dx.doi.org/10.26355/eurrev_201902_17004DOI Listing
February 2019
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microRNA-1205 promotes cell growth by targeting APC2 in lung adenocarcinoma.

Eur Rev Med Pharmacol Sci 2019 Feb;23(3):1125-1133

Department of Respiratory Medicine, First Affiliated Hospital of China Medical University, Shenyang, China.

Objective: An increasing amount of evidence indicates that microRNAs (miRNAs) can be potential diagnostic and prognostic markers for various cancers. In this study, a novel miRNA, miR-1205, was identified in lung adenocarcinoma (LUAD).

Patients And Methods: First, the expression of miR-1205 in tissues was determined and verified to be correlated with the prognosis of patients. Read More

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http://dx.doi.org/10.26355/eurrev_201902_17003DOI Listing
February 2019

MicroRNA-374b accelerates the development of lung cancer through downregulating PTEN expression via activating PI3K/Akt pathway.

Eur Rev Med Pharmacol Sci 2019 Feb;23(3):1116-1124

Department of Thoracic Surgery, Qianshan hospital, Anshan, China.

Objective: To elucidate whether microRNA-374b could participate in the development of lung cancer (LC) through downregulating PTEN (gene of phosphate and tensin homolog deleted on chromosome ten) expression via activating PI3K/Akt pathway.

Patients And Methods: Expression levels of microRNA-374b and PTEN in LC tissues and adjacent normal tissues were detected by quantitative Real Time-Polymerase Chain Reaction (qRT-PCR). Moreover, the expression level of microRNA-374b in LC cell lines was detected as well. Read More

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http://dx.doi.org/10.26355/eurrev_201902_17002DOI Listing
February 2019

Circulating microRNA array (miR-182, 200b and 205) for the early diagnosis and poor prognosis predictor of non-small cell lung cancer.

Eur Rev Med Pharmacol Sci 2019 Feb;23(3):1108-1115

Laboratory Medicine, People's Hospital of Rizhao, Rizhao, China.

Objective: Non-small cell lung cancer (NSCLC) is the most common cause for cancer-related mortality worldwide. Currently, early detection of NSCLC is one of the main available strategies for improving its prognosis. Due to the lack of non-invasive and convenient tools, early diagnosis of NSCLC remains poor. Read More

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http://dx.doi.org/10.26355/eurrev_201902_17001DOI Listing
February 2019

Long noncoding RNA AK027294 acts as an oncogene in non-small cell lung cancer by up-regulating STAT3.

Authors:
B Chen C-H Ling

Eur Rev Med Pharmacol Sci 2019 Feb;23(3):1102-1107

Department of Respiratory Medicine, The First Affiliated Hospital of Soochow University, Suzhou, China.

Objective: Recent researches have proved that long noncoding RNAs (lncRNAs) play an important role in multiple diseases, including malignant tumors. The aim of this study was to explore the exact role of lncRNA AK027294 in the development of non-small cell lung cancer (NSCLC), and to investigate the possible underlying mechanism.

Patients And Methods: Real Time-quantitative Polymerase Chain Reaction (RT-qPCR) was utilized to detect the AK027294 expression in NSCLC patients. Read More

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http://dx.doi.org/10.26355/eurrev_201902_17000DOI Listing
February 2019

LncRNA BC200 regulates the cell proliferation and cisplatin resistance in non-small cell lung cancer via PI3K/AKT pathway.

Authors:
B-B Gao S-X Wang

Eur Rev Med Pharmacol Sci 2019 Feb;23(3):1093-1101

Cancer Treatment Center, Shandong Provincial Hospital Affiliated to Shandong University, Ji'nan, China.

Objective: Long non-coding RNA (lncRNA) exerts tissue specificity and regulates the occurrence and progression of tumors. Previous bioinformatics showed that lncRNA BC200 is served as an oncogene. However, the specific role of BC200 in lung cancer (LC) is rarely reported. Read More

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http://dx.doi.org/10.26355/eurrev_201902_16999DOI Listing
February 2019

Long noncoding RNA DSCAM-AS1 functions as an oncogene in non-small cell lung cancer by targeting BCL11A.

Authors:
J Liao N Xie

Eur Rev Med Pharmacol Sci 2019 Feb;23(3):1087-1092

Department of Thoracic Surgery, Yantaishan Hospital, Yantai, China.

Objective: Long noncoding RNAs (lncRNAs) have attracted more attention for their role in tumor progression recently. The aim of this study was to investigate the role of DSCAM-AS1 in the progression of non-small cell lung cancer (NSCLC), and to elucidate its possible underlying mechanism.

Patients And Methods: DSCAM-AS1 expression in both NSCLC cells and tissue samples was detected by Real Time quantitative-Polymerase Chain Reaction (RT-qPCR). Read More

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http://dx.doi.org/10.26355/eurrev_201902_16998DOI Listing
February 2019

Down-regulation of miR-1181 indicates a dismal prognosis for nasopharyngeal carcinoma and promoted cell proliferation and metastasis by modulating Wnt/β-catenin signaling.

Authors:
X Hua K-C Fan

Eur Rev Med Pharmacol Sci 2019 Feb;23(3):1077-1086

Department of ENT, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China.

Objective: Our study aimed to investigate the expression pattern, clinicopathological feature and prognostic role of miR-1181 in nasopharyngeal carcinoma (NPC), and to determine the functional effects and potential mechanism of miR-1181 in NPC.

Patients And Methods: The expression levels of miR-1181 were determined in NPC tissues and cell lines by RT-PCR. The clinical data were interpreted by chi-square test, univariate analysis, and multivariate analysis. Read More

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http://dx.doi.org/10.26355/eurrev_201902_16996DOI Listing
February 2019

MiR-601 inhibits the proliferation and metastasis of esophageal squamous cell carcinoma (ESCC) by targeting HDAC6.

Eur Rev Med Pharmacol Sci 2019 Feb;23(3):1069-1076

Intensive Care Unit, Cancer Hospital Affiliated to Zhengzhou University, Zhengzhou, China.

Objective: The aim of this study was to explore the role of microRNA-601 (miR-601) in the proliferation and invasion of esophageal squamous cell carcinoma (ESCC) cells, thereby providing new thoughts for prognosis evaluation and targeted therapy of ESCC.

Patients And Methods: 23 pairs of ESCC tissue samples and adjacent normal tissues were collected, and the expression level of miR-601 was detected. Biological information analysis and Luciferase report gene assay were used to verify the potential target genes of miR-601. Read More

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http://dx.doi.org/10.26355/eurrev_201902_16995DOI Listing
February 2019

The prognostic roles of long non-coding RNA SNHG17 in the patients with gastric cancer.

Eur Rev Med Pharmacol Sci 2019 Feb;23(3):1063-1068

Department of Clinical Laboratory, Linyi Central Hospital, Linyi City, Shandong Province, China.

Objective: Dysregulated long non-coding RNAs (lncRNAs) might exert critical roles in pathways associated with gastric cancer (GC) development. Long non-coding RNA (SNHG17), a newly identified lncRNA, has been reported to be dysregulated in several tumors. Our present study aimed to explore the expression level of SNHG17 in patients with GC and investigate the relationship between the SNHG17 level and the prognosis of GC patients. Read More

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http://dx.doi.org/10.26355/eurrev_201902_16994DOI Listing
February 2019

EGF promotes HIF-1α expression in colorectal cancer cells and tumor metastasis by regulating phosphorylation of STAT3.

Authors:
F-L Zhao C-F Qin

Eur Rev Med Pharmacol Sci 2019 Feb;23(3):1055-1062

Department of Hernia and Abdominal Wall Surgery, Beijing ChaoYang Hospital, Capital Medical University, Beijing, China.

Objective: Hypoxia-inducible factor 1α (HIF-1α) functions importantly in the development of colorectal cancer. HIF-1α is induced by some cytokines and growth factors and is also regulated by another kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathways. Meanwhile, inhibiting HIF-1α expression can inhibit the development of colorectal cancer. Read More

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http://dx.doi.org/10.26355/eurrev_201902_16993DOI Listing
February 2019

Inhibition of autophagy by 3-MA promotes hypoxia-induced apoptosis in human colorectal cancer cells.

Eur Rev Med Pharmacol Sci 2019 Feb;23(3):1047-1054

Department of General Surgery, the Second Affiliated Hospital of Soochow University, Suzhou, China.

Objective: Cell autophagy reduces the sensitivity of cancer cells to therapeutic reagents in various types of human cancer. Therefore, the aim of our study was to use human colorectal cancer HCT116 cells to explore whether inhibition of autophagy by 3-Methyladenine (3-MA, an autophagy inhibitor) is able to enhance hypoxia-induced apoptosis in vitro.

Materials And Methods: HCT116 cells were treated with 3-MA, hypoxia, or 3-MA plus hypoxia, and the autophagy, apoptosis and proliferation of the HCT116 cells were investigated. Read More

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http://dx.doi.org/10.26355/eurrev_201902_16992DOI Listing
February 2019

LncRNA 00152 promotes the development of hepatocellular carcinoma by activating JAK2/STAT3 pathway.

Eur Rev Med Pharmacol Sci 2019 Feb;23(3):1038-1046

Department of Hepatobiliary Surgery, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, China.

Objective: The aim of this study was to explore the regulatory role of lncRNA 00152 and JAK2/STAT3 pathway in the pathogenesis of hepatocellular carcinoma (HCC), and to investigate the possible underlying mechanism.

Patients And Methods: Expression levels of lncRNA 00152 in HCC tissues, matched para-cancerous tissues and normal liver tissues were detected by quantitative Real Time-Polymerase Chain Reaction (qRT-PCR), respectively. The correlation between lncRNA 00152 expression and pathological characteristics of HCC patients was analyzed. Read More

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http://dx.doi.org/10.26355/eurrev_201902_16991DOI Listing
February 2019

MiR-155-5p affects Wilms' tumor cell proliferation and apoptosis via targeting CREB1.

Eur Rev Med Pharmacol Sci 2019 Feb;23(3):1030-1037

Department of Pediatric Surgery, the First Hospital of Jilin University, Changchun, China.

Objective: The aim of this study was to explore the role of microRNA-155-5p (miR-155-5p) in regulating the proliferation and apoptosis of Wilm's tumor (WT), and to investigate the possible underlying mechanism.

Patients And Methods: The expression levels of miR-155-5p in 37 pairs of WT clinical samples, as well as WT cell line (G401), were detected by quantitative reverse transcription polymerase chain reaction (qRT-PCR). MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) assay and flow cytometry assay were used to detect the effects of miR-155-5p on cell proliferation, cycle and apoptosis. Read More

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http://dx.doi.org/10.26355/eurrev_201902_16990DOI Listing
February 2019

LncSNHG14 promotes the development and progression of bladder cancer by targeting miRNA-150-5p.

Eur Rev Med Pharmacol Sci 2019 Feb;23(3):1022-1029

Department of Urology, The Second Affiliated Hospital of Soochow University, Suzhou, China.

Objective: To elucidate whether lncSNHG14 could influence the proliferative potential and cell cycle progression of bladder cancer cells via binding to microRNA-150-5p (miRNA-150-5p). We aim to investigate the potential mechanism of miRNA-150-5p in the occurrence and progression of bladder cancer (BCa).

Patients And Methods: Expression levels of SNHG14 and miRNA-150-5p in BCa tissues and normal bladder tissues were determined by quantitative Real Time-Polymerase Chain Reaction (qRT-PCR). Read More

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http://dx.doi.org/10.26355/eurrev_201902_16989DOI Listing
February 2019

lncRNA-RMRP promotes proliferation, migration and invasion of bladder cancer via miR-206.

Eur Rev Med Pharmacol Sci 2019 Feb;23(3):1012-1021

Beijing Rehabilitation Hospital Affiliated to Capital Medical University, Beijing, China.

Objective: The incidence of bladder cancer (BC) is common in the world, but its detail mechanisms for occurrence and development remain unclear. Recently, long non-coding RNAs (lncRNAs) have been observed to play an important role in many different diseases. In this research, we mainly explored the role of the RNA component of mitochondrial RNA processing endoribonuclease (lncRNA-RMRP) in bladder cancer. Read More

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http://dx.doi.org/10.26355/eurrev_201902_16988DOI Listing
February 2019

MicroRNA-95-3p promoted the development of prostatic cancer via regulating DKK3 and activating Wnt/β-catenin pathway.

Eur Rev Med Pharmacol Sci 2019 Feb;23(3):1002-1011

Department of Urology, Huadu District People's Hospital, Southern Medical University, Guangzhou, China.

Objective: Previous studies have shown that microRNA-95-3p (miR-95-3p) plays a crucial role in multiple human cancers except for prostatic cancer (PCa). Therefore, the function of miR-95-3p was investigated in PCa in the present work.

Patients And Methods: The expression of miR-95-3p was measured by Real Time-quantitative Polymerase Chain Reaction (RT-qPCR) assay. Read More

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http://dx.doi.org/10.26355/eurrev_201902_16987DOI Listing
February 2019

MiR-492 exerts tumor-promoting function in prostate cancer through repressing SOCS2 expression.

Eur Rev Med Pharmacol Sci 2019 Feb;23(3):992-1001

Department of Urology, The First Affiliated Hospital of Jinan University, Guangzhou, China.

Objective: MiRNAs have been verified to play a role in the development and progression of prostate cancer (PCa). However, the role of miR-492 in PCa has not been mentioned. We aim to detect the expression of miR-492 in PCa and explore its underlying mechanism. Read More

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http://dx.doi.org/10.26355/eurrev_201902_16986DOI Listing
February 2019

MicroRNA-340-5p suppresses osteosarcoma development by down-regulating the Wnt/β-catenin signaling pathway via targeting the STAT3 gene.

Eur Rev Med Pharmacol Sci 2019 Feb;23(3):982-991

Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, China.

Objective: To study the effects of miR-340-5p on the proliferation of osteosarcoma (OS) U2OS cells.

Patients And Methods: miR-340-5p expression was measured by quantitative Real-time Polymerase Chain Reaction (qRT-PCR) in cancer tissues and paracancerous tissues from OS patients, and in OS cell line U2OS and normal osteoblast cell line hFOB1.19. Read More

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http://dx.doi.org/10.26355/eurrev_201902_16985DOI Listing
February 2019

MicroRNA-1269a promotes the occurrence and progression of osteosarcoma by inhibit-ing TGF-β1 expression.

Eur Rev Med Pharmacol Sci 2019 Feb;23(3):972-981

Departments of Radiology, China-Japan Union Hospital of Jilin University, Changchun, China.

Objective: MicroRNAs are endogenous, non-coding small RNAs that are capable of regulating biological and pathological processes. Previous studies have shown that microRNA-1269a serves as an oncogene. However, the role of microRNA-1269a in the pathogenesis of osteosarcoma (OS) has not been reported. Read More

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http://dx.doi.org/10.26355/eurrev_201902_16984DOI Listing
February 2019

Suppression of connexin 43 expression by miR-106a promotes melanoma cell proliferation.

Eur Rev Med Pharmacol Sci 2019 Feb;23(3):965-971

Department of Burn and Plastic Surgery, Cangzhou Central Hospital, Cangzhou City, Hebei Province, China.

Objective: Connexin 43 (Cx43), a vital gap junction protein is reported to be involved in melanoma progression. The aim of the study is to investigate the regulatory role of Cx43 in melanoma.

Materials And Methods: Western blot assay was used to detect the protein expression of Cx43 in melanoma cells and the human epidermal melanocytes (HEMn). Read More

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http://www.europeanreview.org/article/16983
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http://dx.doi.org/10.26355/eurrev_201902_16983DOI Listing
February 2019
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Comparison between antimicrobial-coated sutures and uncoated sutures for the prevention of surgical site infections in plastic surgery: a double blind control trial.

Eur Rev Med Pharmacol Sci 2019 Feb;23(3):958-964

Department of General Surgery, Plastic Surgery "P. Valdoni", Policlinico Umberto I, Sapienza University of Rome, Rome, Italy.

Objective: Surgical site infection (SSI) produces considerable morbidity and increases health care costs. One of its causes is microbial adherence to the surgical sutures surface. A strategy to avoid microbial colonization is the use of antimicrobial-impregnated sutures. Read More

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http://dx.doi.org/10.26355/eurrev_201902_16982DOI Listing
February 2019

Circ-VANGL1 promotes the progression of osteoporosis by absorbing miRNA-217 to regulate RUNX2 expression.

Eur Rev Med Pharmacol Sci 2019 Feb;23(3):949-957

Department of Orthopedics, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.

Objective: This study aims to investigate whether circ-VANGL1 can promote the progression of osteoporosis (OP) by absorbing miRNA-217 to regulate RUNX2 expression.

Patients And Methods: The serum levels of circ-VANGL1, miRNA-217 and RUNX2 in OP patients and non-OP patients were detected by quantitative Real Time-Polymerase Chain Reaction (qRT-PCR). Their expression levels in human bone marrow mesenchymal stem cells (hBMSCs) at different time points of osteogenesis differentiation were determined as well. Read More

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http://dx.doi.org/10.26355/eurrev_201902_16981DOI Listing
February 2019

MicroRNA-23c inhibits articular cartilage damage recovery by regulating MSCs differentiation to chondrocytes via reducing FGF2.

Eur Rev Med Pharmacol Sci 2019 Feb;23(3):941-948

Department of Orthopaedics, Changzhou Hospital of traditional Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Changzhou, China.

Objective: The aim of the study was to explore the role of microRNA-23c in the differentiation of marrow stromal cells (MSCs) to chondrocytes and its potential mechanism.

Materials And Methods: MSCs were first isolated from rat bone marrow for cell culture. Surface antigens of MSCs (CD29 and CD34) were identified by flow cytometry. Read More

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http://dx.doi.org/10.26355/eurrev_201902_16980DOI Listing
February 2019

Role of interleukin-10 in the synovial fluid of the anterior cruciate ligament injured knee.

Eur Rev Med Pharmacol Sci 2019 Feb;23(3):932-940

Orthopedic Department, San Gerardo Hospital, Monza, Italy.

Objective: This review assesses the roles of IL-10 in post ACL reconstruction OA, and highlights the potential therapeutic effects of this cytokine.

Materials And Methods: We conducted a systematic review of the literature in order to consolidate evidence of IL10 profiles in synovial fluid (SF) of patients with ACL tears. The review was conducted in accordance with the PRISMA statement. Read More

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http://www.europeanreview.org/article/16979
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http://dx.doi.org/10.26355/eurrev_201902_16979DOI Listing
February 2019
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Influence of miR-34a on preeclampsia through the Notch signaling pathway.

Eur Rev Med Pharmacol Sci 2019 Feb;23(3):923-931

Department of Obstetrics and Gynecology, Nanjing Maternity and Child Health Care Institute, The Affiliated Obstetrics and Gynecology Hospital with Nanjing Medical University, Nanjing, China.

Objective: The aim of this study was to investigate the influence of micro-ribonucleic acid-34a (miR-34a) on preeclampsia through the Notch signaling pathway.

Patients And Methods: The expressions of miR-34a, Notch-1, Notch-2, and Notch-3 in the placenta of 39 preeclampsia patients and 42 normal patients were detected by immunohistochemistry and Reverse Transcription-Polymerase Chain Reaction (RT-PCR). The correlations between miR-34a expression with the expressions of Notch-1, Notch-2 and Notch-3 were analyzed, respectively. Read More

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http://dx.doi.org/10.26355/eurrev_201902_16978DOI Listing
February 2019

Salivary pH and flow rate in menopausal women.

Eur Rev Med Pharmacol Sci 2019 Feb;23(3):918-922

Department of Translational Medicine, University of Eastern Piedmont, Novara, Italy.

Objective: This study aims at determining pH and Flow Rate (FR) of Unstimulated Whole Saliva (UWS) in a sample of 120 ♀ (60 menopausal women and 60 healthy fertile women with similar mean age); detecting the DMFT index (Decayed, Missing, Filled Teeth index) and evaluating any correlations between pH, FR, age and DMFT.

Patients And Methods: Concerning the day before sample collection, patients were advised to keep a relaxed attitude and not to practice sports. They were also told to not eat or drink during the hour preceding sampling procedures. Read More

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http://dx.doi.org/10.26355/eurrev_201902_16977DOI Listing
February 2019