15,899 results match your criteria European Oncology & Haematology [Journal]


Voice and Quality-of-Life Outcomes of Diode Laser for Tis-T1a Glottic Cancer.

Ear Nose Throat J 2019 Apr 23:145561319839868. Epub 2019 Apr 23.

2 Ankara Oncology Education and Research Hospital, Clinic of Otolaryngology, Ankara, Turkey.

The aim of this prospective study was to analyze the voice and quality-of-life outcomes of microscopic diode laser surgery (MDLS). The study was conducted on a series of 46 patients with Tis-T1a glottic carcinoma treated with microscopic endolaryngeal diode laser surgery. Patients were asked to complete the Voice Handicap Index and quality-of-life questionnaires of the European Organization for Research and Treatment of Cancer. Read More

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http://dx.doi.org/10.1177/0145561319839868DOI Listing

Clinical features in proven and probable invasive fungal disease in children and adolescents at a pediatric referral center: a 5-year experience.

World J Pediatr 2019 Apr 22. Epub 2019 Apr 22.

Department of Hematology and Oncology, Children's Cancer Center, Kobe Children's Hospital, Minatojima-Minamimachi 1-6-7, Chuo-ku, Kobe, 650-0047, Japan.

Background: There is limited information concerning the overall epidemiology of invasive fungal disease (IFD) in children. The aim of this study was to clarify the clinical features of IFD in a tertiary pediatric care hospital.

Methods: Patients diagnosed with proven or probable IFD at our hospital between 2011 and 2015 were retrospectively reviewed. Read More

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http://dx.doi.org/10.1007/s12519-019-00259-xDOI Listing

Favorable pharmacokinetics in hemophilia B for nonacog beta pegol versus recombinant factor IX-Fc fusion protein: A randomized trial.

Res Pract Thromb Haemost 2019 Apr 23;3(2):268-276. Epub 2019 Mar 23.

Department for Internal Medicine Vascular Medicine and Haemostaseology Vivantes Klinikum Berlin Germany.

Background And Objective: Nonacog beta pegol (N9-GP) and recombinant factor IX-Fc fusion protein (rFIXFc) are extended half-life rFIX compounds. We report the first single-dose pharmacokinetic trial of N9-GP and rFIXFc.

Patients/methods: Paradigm 7 was a multicenter, open-label, randomized, crossover trial in previously treated (>150 exposure days) adults with congenital hemophilia B (FIX activity ≤2%). Read More

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http://doi.wiley.com/10.1002/rth2.12192
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http://dx.doi.org/10.1002/rth2.12192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462750PMC
April 2019
1 Read

miR-125b Upregulates miR-34a and Sequentially Activates Stress Adaption and Cell Death Mechanisms in Multiple Myeloma.

Mol Ther Nucleic Acids 2019 Mar 13;16:391-406. Epub 2019 Mar 13.

Department of Precision Medicine, University of Campania "Luigi Vanvitelli," 80138 Naples, Italy; IRGS, Biogem, Molecular and Precision Oncology Laboratory, Via Camporeale, 83031 Ariano Irpino, Italy. Electronic address:

miR-125b, ubiquitously expressed and frequently dysregulated in several tumors, has gained special interest in the field of cancer research, displaying either oncogenic or oncosuppressor potential based on tumor type. We have previously demonstrated its tumor-suppressive role in multiple myeloma (MM), but the analysis of molecular mechanisms needs additional investigation. The purpose of this study was to explore the effects of miR-125b and its chemically modified analogs in modulating cell viability and cancer-associated molecular pathways, also focusing on the functional aspects of stress adaptation (autophagy and senescence), as well as programmed cell death (apoptosis). Read More

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http://dx.doi.org/10.1016/j.omtn.2019.02.023DOI Listing

New Paradigms in Reconstructive Microsurgery Education.

Ann Plast Surg 2019 Apr 3. Epub 2019 Apr 3.

Reconstructive Microsurgery Unit, Careggi University Hospital, Florence, Italy.

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http://dx.doi.org/10.1097/SAP.0000000000001825DOI Listing

Stem-cell regenerative medicine as applied to the penis.

Curr Opin Urol 2019 Apr 16. Epub 2019 Apr 16.

Department of Urology.

Purpose Of Review: Tissue engineering and regenerative medicine has emerged as a new scientific interdisciplinary field focusing on developing new strategies to repair or recreate tissues and organs. This review gathers findings on erectile dysfunction and, Peyronie's disease from recent preclinical and clinical studies under heading of stem-cell regenerative medicine.

Recent Findings: Over the last 2 years, preclinical studies on rat models demonstrated the tangible beneficial role of stem cells and stromal vascular fraction in the context of preventing fibrosis and restoring erectile function in different animal models of Erectile dysfunction and Peyronie's disease. Read More

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http://dx.doi.org/10.1097/MOU.0000000000000636DOI Listing

A GCIG international survey: clinical practice patterns of sentinel lymph node biopsies in cervical cancer.

Arch Gynecol Obstet 2019 Apr 21. Epub 2019 Apr 21.

Department of Gynecology With Center for Oncological Surgery, Charité Universtitätmedizin, Charité Platz 1, 10117, Berlin, Germany.

Purpose: To evaluate the practice patterns among centers and physicians worldwide regarding sentinel lymph node biopsies (SLNB) in cervical cancer (CC) patients.

Method: A validated 35-item questionnaire regarding SLNB in CC supported by the Gynecologic Cancer Intergroup (GCIG), and sponsored by the North-Eastern German Society of Gynaecologic-Oncology (NOGGO) was sent to all major gynecological cancer societies across the globe for further distribution from October 2015 and continued for a period of 7 months.

Results: One hundred and sixty-one institutions from around the world participated. Read More

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http://link.springer.com/10.1007/s00404-019-05164-2
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http://dx.doi.org/10.1007/s00404-019-05164-2DOI Listing
April 2019
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Galectin-3, a novel endogenous TREM2 ligand, detrimentally regulates inflammatory response in Alzheimer's disease.

Acta Neuropathol 2019 Apr 20. Epub 2019 Apr 20.

Department of Experimental Medical Science, Experimental Neuroinflammation Laboratory, Lund University, 221 84, Lund, Sweden.

Alzheimer's disease (AD) is a progressive neurodegenerative disease in which the formation of extracellular aggregates of amyloid beta (Aβ) peptide, fibrillary tangles of intraneuronal tau and microglial activation are major pathological hallmarks. One of the key molecules involved in microglial activation is galectin-3 (gal3), and we demonstrate here for the first time a key role of gal3 in AD pathology. Gal3 was highly upregulated in the brains of AD patients and 5xFAD (familial Alzheimer's disease) mice and found specifically expressed in microglia associated with Aβ plaques. Read More

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http://dx.doi.org/10.1007/s00401-019-02013-zDOI Listing

International prospective observational study on intracranial pressure in intensive care (ICU): the SYNAPSE-ICU study protocol.

BMJ Open 2019 Apr 20;9(4):e026552. Epub 2019 Apr 20.

Department of Public Health, Erasmus MC, Rotterdam, Netherlands.

Introduction: Intracranial pressure (ICP) monitoring is commonly used in neurocritical care patients with acute brain injury (ABI). Practice about indications and use of ICP monitoring in patients with ABI remains, however, highly variable in high-income countries, while data on ICP monitoring in low and middle-income countries are scarce or inconsistent. The aim of the SYNAPSE-ICU study is to describe current practices of ICP monitoring using a worldwide sample and to quantify practice variations in ICP monitoring and management in neurocritical care ABI patients. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-026552DOI Listing
April 2019
1 Read

Epoetin alfa for the treatment of myelodysplastic syndrome-related anemia: A review of clinical data, clinical guidelines, and treatment protocols.

Leuk Res 2019 Mar 27;81:35-42. Epub 2019 Mar 27.

Institut Multidisciplinaire d'Oncologie, Clinique de Genolier, Genolier, Switzerland. Electronic address:

Myelodysplastic syndromes (MDS) are characterized by ineffective hematopoiesis, leading to hematopoietic precursor cell apoptosis and peripheral blood cytopenias. Anemia is the most frequently experienced cytopenia and is the main cause of MDS symptoms, with fatigue and dyspnea contributing to reduced quality of life and increased morbidity. As MDS disease course and prognosis is influenced by disease factors, prognostic scoring systems have been developed for MDS to aid clinical and therapeutic decisions following diagnosis. Read More

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http://dx.doi.org/10.1016/j.leukres.2019.03.006DOI Listing

An updated European Organisation for Research and Treatment of Cancer (EORTC) protocol for pathological evaluation of sentinel lymph nodes for melanoma.

Eur J Cancer 2019 Apr 17;114:1-7. Epub 2019 Apr 17.

Department of Surgical Oncology, Netherlands Cancer Institute Antoni van Leeuwenhoek, Amsterdam, the Netherlands.

The sentinel lymph node (SLN) biopsy is a highly accurate staging procedure and the most important prognostic factor in melanoma patients. The European Organisation for Research and Treatment of Cancer (EORTC) Melanoma Group aimed to design an updated evolved SLN protocol for the histopathological workup and reporting. We herein recommend extending the distance between steps according to the short axis dimension of the lymph node and optimise both conventional sectioning and staining procedures including immunohistochemistry. Read More

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http://dx.doi.org/10.1016/j.ejca.2019.03.010DOI Listing

Dietary calories and lipids synergistically shape adipose tissue cellularity during postnatal growth.

Mol Metab 2019 Apr 5. Epub 2019 Apr 5.

DKFZ Junior Group Metabolism and Stem Cell Plasticity, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg 69120, Germany. Electronic address:

Objective: The susceptibility to abdominal obesity and the metabolic syndrome is determined to a substantial extent during childhood and adolescence, when key adipose tissue characteristics are established. Although the general impact of postnatal nutrition is well known, it is not clear how specific dietary components drive adipose tissue growth and how this relates to the risk of metabolic dysfunction in adulthood.

Methods: Adipose tissue growth including cell proliferation was analyzed in juvenile mice upon dietary manipulation with in vivo nucleotide labeling. Read More

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http://dx.doi.org/10.1016/j.molmet.2019.03.012DOI Listing

Time trends of short-term mortality for octogenarians undergoing a colorectal resection in North Europe.

Eur J Surg Oncol 2019 Apr 9. Epub 2019 Apr 9.

Department of Surgical Oncology, Leiden University Medical Center, the Netherlands. Electronic address:

Background: Decreased cancer specific survival in older colorectal patients is mainly due to mortality in the first year, emphasizing the importance of the first postoperative year. This study aims to gain an overview and time trends of short-term mortality in octogenarians (≥80 years) with colorectal cancer across four North European countries.

Methods: Patients of 80 years or older, operated for colorectal cancer (stage I-III) between 2005 and 2014, were included. Read More

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http://dx.doi.org/10.1016/j.ejso.2019.03.041DOI Listing

[Prophylactic hysterectomy in Lynch syndrome: feasibility and outcomes].

Gynecol Obstet Fertil Senol 2019 Apr 16. Epub 2019 Apr 16.

Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges-Pompidou, Chirurgie Cancérologique Gynécologique et du Sein, Paris, France; Université Paris Descartes, INSERM UMR-S 747, Paris, France; Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine, Paris, France. Electronic address:

Objectives: Lynch syndrome (LS) is a hereditary predisposition to cancers, first of all, colo-rectal and endometrial cancers in women. Although recommended, gynecologic screening has never proven its benefit. Prophylactic surgery can be consider once the parental project is completed. Read More

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http://dx.doi.org/10.1016/j.gofs.2019.04.010DOI Listing

MDM4 is targeted by 1q gain and drives disease in Burkitt lymphoma.

Cancer Res 2019 Apr 18. Epub 2019 Apr 18.

University Hospital and University of Zurich

Oncogenic MYC activation promotes proliferation in Burkitt lymphoma (BL), but also induces cell cycle arrest and apoptosis mediated by p53, a tumor suppressor that is mutated in 40% of BL cases. To identify molecular dependencies in BL, we performed RNAi-based, loss-of-function screening in eight BL cell lines and integrated non-BL RNAi screens and genetic data. We identified 76 genes essential to BL, including genes associated with hematopoietic cell differentiation (FLI1, BCL11A) or B cell development and activation (PAX5, CDKN1B, JAK2, CARD11) and found a number of context-specific dependencies including oncogene addiction in cell lines with TCF3/ID3 or MYD88 mutation. Read More

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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http://dx.doi.org/10.1158/0008-5472.CAN-18-3438DOI Listing
April 2019
2 Reads

The 2017 Network Tools and Applications in Biology (NETTAB) workshop: aims, topics and outcomes.

BMC Bioinformatics 2019 Apr 18;20(Suppl 4):125. Epub 2019 Apr 18.

ICAR-CNR, Institute for high performance computing and networking, National Research Council of Italy, Palermo, 90146, Italy.

The 17th International NETTAB workshop was held in Palermo, Italy, on October 16-18, 2017. The special topic for the meeting was "Methods, tools and platforms for Personalised Medicine in the Big Data Era", but the traditional topics of the meeting series were also included in the event. About 40 scientific contributions were presented, including four keynote lectures, five guest lectures, and many oral communications and posters. Read More

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https://bmcbioinformatics.biomedcentral.com/articles/10.1186
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http://dx.doi.org/10.1186/s12859-019-2681-0DOI Listing
April 2019
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Selenium and Selenoprotein P Deficiency Correlates with Complications and Adverse Outcome After Major Trauma.

Shock 2019 Apr 12. Epub 2019 Apr 12.

Department of Trauma Surgery, University Hospital Munich, Ludwig-Maximilians-University, Munich, Germany.

Background: A declining selenium (Se) status constitutes a characteristic of critical illness and may affect disease course and survival. The dynamics of trauma-induced changes in biomarkers of Se status are poorly characterized, and an association with multiple organ failure (MOF) and mortality can be hypothesized. It was the aim of this study to investigate Se and selenoprotein P (SELENOP) concentrations in major trauma patients during the early posttraumatic period. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001344DOI Listing

The impact of vaginal dilator use on vaginal stenosis and sexual quality of life in women treated with adjuvant radiotherapy for endometrial cancer.

Strahlenther Onkol 2019 Apr 17. Epub 2019 Apr 17.

Department of Radiation Oncology, University Hospital Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany.

Background: Despite a lack of evidence and low compliance, current guidelines recommend the use of a vaginal dilator (VD) after pelvic radiotherapy (RT). We analyzed the effect of VD on vaginal stenosis (VS) and its influence on sexual quality of life (QoL) in women treated with adjuvant RT for endometrial cancer (EC).

Methods: Between 2014 and 2015, 56 consecutive patients were instructed to use a VD after completion of treatment. Read More

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http://dx.doi.org/10.1007/s00066-019-01466-1DOI Listing

Robotic lobectomy has the greatest benefit in patients with marginal pulmonary function.

J Thorac Dis 2019 Mar;11(Suppl 3):S322-S324

Division of Thoracic Surgery, European Institute of Oncology, University of Milan, Milan, Italy.

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http://dx.doi.org/10.21037/jtd.2018.12.132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424766PMC

Comparison of pulmonary metastasectomy and stereotactic body radiation therapy for the treatment of lung metastases.

J Thorac Dis 2019 Mar;11(Suppl 3):S280-S282

Department of Thoracic Surgery, IRCCS European Institute of Oncology, Milan, Italy.

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http://jtd.amegroups.com/article/view/26804/20211
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http://dx.doi.org/10.21037/jtd.2019.01.72DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424761PMC
March 2019
1 Read

Endoscopic Resections in Inflammatory Bowel Disease: A Multicentre European Outcomes Study.

J Crohns Colitis 2019 Apr 17. Epub 2019 Apr 17.

Department of Gastroenterology, Queen Alexandra Hospital, Southwick Hill Road, Portsmouth.

Background: Inflammatory bowel disease is associated with an increased risk of colorectal cancer, with estimates ranging from 2-18%, depending on the duration of colitis. The management of neoplasia in colitis remains controversial. Current guidelines recommend endoscopic resection if the lesion is clearly visible with distinct margins. Read More

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https://academic.oup.com/ecco-jcc/advance-article/doi/10.109
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http://dx.doi.org/10.1093/ecco-jcc/jjz075DOI Listing
April 2019
2 Reads

New and old biomarkers in the differential diagnosis of lung cancer: Pro-gastrin-releasing peptide in comparison with neuron-specific enolase, carcinoembryonic antigen, and CYFRA 21-1.

Int J Biol Markers 2019 Apr 17:1724600819834235. Epub 2019 Apr 17.

5 Division of Laboratory Medicine, Humanitas Clinical and Research Center, IRCCS, Rozzano Milan, Italy.

Background: Testing for circulating biomarkers in lung cancer is hampered by the insufficient specificity. We aimed to assess the relative diagnostic accuracy of pro-gastrin-releasing peptide (ProGRP) for the differential diagnosis of small cell lung cancer and compare it with more conventional biomarkers.

Methods: We enrolled a cohort of 390 patients with a clinical suspicion of lung cancer and for whom a histologic assessment was available. Read More

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http://dx.doi.org/10.1177/1724600819834235DOI Listing

Absolute basophil count is associated with time to recurrence in patients with high-grade T1 bladder cancer receiving bacillus Calmette-Guérin after transurethral resection of the bladder tumor.

World J Urol 2019 Apr 16. Epub 2019 Apr 16.

Department of Clinical Medicine and Surgery, Federico II University of Naples, Naples, Italy.

Background: Basophils, eosinophils and monocytes may be involved in BCG-induced immune responses and be associated with outcomes of bladder cancer patients receiving intravesical BCG. Our objective was to explore the association of baseline counts of basophils, eosinophils and monocytes with outcomes of patients with high-grade T1 bladder cancer receiving a standard course of intravesical BCG.

Methods: We retrospectively reviewed medical records of patients with primary T1 HG/G3 bladder cancer. Read More

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http://dx.doi.org/10.1007/s00345-019-02754-2DOI Listing

Research driving innovation: what are key factors for successful integration of translational science into oncology care concepts? 5th European Roundtable Meeting (ERTM) May 4th, 2018, Berlin, Germany.

J Cancer Res Clin Oncol 2019 Apr 16. Epub 2019 Apr 16.

German Cancer Society, Berlin, Germany.

Purpose: To identify key factors for successful integration of translational science into cancer care.

Results: Organisation of the health care system matters to optimally bridge between public and private cancer research, cancer registries and routine care. Currently, there are deficits on various levels of connectivity. Read More

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http://link.springer.com/10.1007/s00432-019-02916-0
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http://dx.doi.org/10.1007/s00432-019-02916-0DOI Listing
April 2019
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Precise definition of PTEN C-terminal epitopes and its implications in clinical oncology.

NPJ Precis Oncol 2019 15;3:11. Epub 2019 Apr 15.

Biocruces-Bizkaia Health Research Institute, Barakaldo, Spain.

Anti-PTEN monoclonal antibodies (mAb) are arising as important tools for immunohistochemistry (IHC) and protein quantification routine analysis in clinical oncology. Although an effort has been made to document the reliability of tumor tissue section immunostaining by anti-PTEN mAb, and to standardize their IHC use in research and in the clinical practice, the precise topological and biochemical definition of the epitope recognized by each mAb has been conventionally overlooked. In this study, six commercial anti-PTEN mAb have been validated and characterized for sensitivity and specificity by IHC and FISH, using a set of prostate and urothelial bladder tumor specimens, and by immunoblot, using PTEN positive and PTEN negative human cell lines. Read More

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http://dx.doi.org/10.1038/s41698-019-0083-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465295PMC

Home parenteral nutrition provision modalities for chronic intestinal failure in adult patients: An international survey.

Clin Nutr 2019 Mar 25. Epub 2019 Mar 25.

Salford Royal NHS Foundation Trust, Salford, United Kingdom.

Background & Aims: The safety and effectiveness of a home parenteral nutrition (HPN) program depends both on the expertise and the management approach of the HPN center. We aimed to evaluate both the approaches of different international HPN-centers in their provision of HPN and the types of intravenous supplementation (IVS)-admixtures prescribed to patients with chronic intestinal failure (CIF).

Methods: In March 2015, 65 centers from 22 countries enrolled 3239 patients (benign disease 90. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02615614193012
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http://dx.doi.org/10.1016/j.clnu.2019.03.010DOI Listing
March 2019
4 Reads

Health-related quality of life as an endpoint in oncology phase I trials: a systematic review.

BMC Cancer 2019 Apr 16;19(1):361. Epub 2019 Apr 16.

Methodology and Quality of Life in Oncology Unit, INSERM UMR 1098, University Hospital of Besançon, Besançon, France.

Background: Phase I trials aim to identify the recommended dose for further development. Health-related quality of life (HRQoL) could be a complement to the usual National Cancer Institute Common Terminology Criteria for Adverse Events (NCI-CTCAE) scale to detect adverse events and define the doses. The objective of this study is to review the phase I in oncology which used HRQoL as endpoint. Read More

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https://bmccancer.biomedcentral.com/articles/10.1186/s12885-
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http://dx.doi.org/10.1186/s12885-019-5579-3DOI Listing
April 2019
1 Read

Surgical Treatment of Bilateral Lung Cancers: Long-Term Outcomes and Prognostic Factors.

Thorac Cardiovasc Surg 2019 Apr 16. Epub 2019 Apr 16.

Department of Thoracic Surgery, European Institute of Oncology, Milan, Italy.

Background:  Bilateral lung neoplasms are becoming more common, but distinguishing two primary lung cancers from metastatic disease can be difficult and only long-term follow-up after treatment can disclose the real behavior of the disease.The present study aimed to identify the appropriate candidates for bilateral surgical resections from the perspective of short-term postoperative complications and long-term outcomes.

Methods:  Two hundred and fifteen consecutive patients undergoing bilateral pulmonary resection for lung cancers over a 20-year period were analyzed. Read More

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http://dx.doi.org/10.1055/s-0039-1685472DOI Listing
April 2019
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GNrep mouse: A reporter mouse for front-rear cell polarity.

Genesis 2019 Apr 16:e23299. Epub 2019 Apr 16.

Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal.

Cell migration is essential during development, regeneration, homeostasis, and disease. Depending on the microenvironment, cells use different mechanisms to migrate. Yet, all modes of migration require the establishment of an intracellular front-rear polarity axis for directional movement. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/dvg.23299
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http://dx.doi.org/10.1002/dvg.23299DOI Listing
April 2019
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Intratunical injection of autologous adipose stromal vascular fraction reduces collagen III expression in a rat model of chronic penile fibrosis.

Int J Impot Res 2019 Apr 15. Epub 2019 Apr 15.

Laboratory for Experimental Urology, Organ systems, Department of Development and Regeneration, University of Leuven, Leuven, Belgium.

Previous studies have shown that the injection of adipose stem cells and stromal vascular fraction(SVF) into the tunica albuginea (TA) during the inflammatory phase in a rat model of Peyronie's disease(PD) prevented the development of TA fibrosis. Our aim was to investigate whether local injection of SVF can reduce established fibrosis in a rat model of chronic phase of PD. Eighteen-male 12-wk-old Sprague-Dawley rats were divided in three equal groups: sham, PD without treatment (PD) and PD treated with SVF(PD-SVF). Read More

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http://dx.doi.org/10.1038/s41443-019-0136-9DOI Listing

Comparison between patient-reported outcomes after enucleation and proton beam radiotherapy for uveal melanomas: a 2-year cohort study.

Eye (Lond) 2019 Apr 15. Epub 2019 Apr 15.

Liverpool Ocular Oncology Centre, Royal Liverpool and Broadgreen University Hospital, NHS Trust, Prescot St, Liverpool, L7 8XP, UK.

Background: Uveal melanomas affect 2-8 per million Europeans each year. Approximately 35%, are treated by enucleation. Proton beam radiotherapy (PBR) can be an eye-conserving alternative to enucleation for patients who wish to retain the eye. Read More

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http://www.nature.com/articles/s41433-019-0440-0
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http://dx.doi.org/10.1038/s41433-019-0440-0DOI Listing
April 2019
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Partially methylated domains are hypervariable in breast cancer and fuel widespread CpG island hypermethylation.

Nat Commun 2019 Apr 15;10(1):1749. Epub 2019 Apr 15.

Department of Molecular Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Radboud University, PO Box 9101, Nijmegen, 6500 HB, The Netherlands.

Global loss of DNA methylation and CpG island (CGI) hypermethylation are key epigenomic aberrations in cancer. Global loss manifests itself in partially methylated domains (PMDs) which extend up to megabases. However, the distribution of PMDs within and between tumor types, and their effects on key functional genomic elements including CGIs are poorly defined. Read More

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http://dx.doi.org/10.1038/s41467-019-09828-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465362PMC

Options for the Interpretation of and Recommendations for Acting on Different PROMs in Daily Clinical Practice Using KLIK.

Med Care 2019 May;57 Suppl 5 Suppl 1:S52-S58

Psychosocial Department, Amsterdam UMC, University of Amsterdam, Emma Children's Hospital, Amsterdam.

Introduction: This paper describes the different ways in which information is being fed back to health care providers (HCPs) using the Dutch evidence-based KLIK Patient-Reported Outcome Measures (PROMs) portal (www.hetklikt.nu). Read More

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http://dx.doi.org/10.1097/MLR.0000000000001061DOI Listing

Frontal sinus ablation (Riedel-Mosher's procedure): indications and role in the endonasal endoscopic era.

Rhinology 2019 Apr 15. Epub 2019 Apr 15.

Division of Otorhinolaryngology, Department of Biotechnology and Life Sciences, University of Insubria, ASST Sette Laghi, Ospedale di Circolo e Fondazione Macchi, Varese, Italy.

Background: The aim of this article is to describe the Riedel-Mosher's surgical technique and identify its current role in the endoscopic endonasal era based on the experience of a tertiary care medical centre. It also provides a brief excursus on materials available for frontal reconstruction.

Methods: A retrospective review of patients submitted to Riedel-Mosher's procedure from 2005 to 2018 at a single tertiary care centre was carried out. Read More

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http://dx.doi.org/10.4193/Rhin18.197DOI Listing
April 2019
2 Reads

Metabolomic insights into pathophysiological mechanisms and biomarker discovery in clear cell - renal cell carcinoma.

Expert Rev Mol Diagn 2019 Apr 13. Epub 2019 Apr 13.

a Department of Emergency and Organ Transplantation - Urology, Andrology and Kidney Transplantation Unit , University of Bari , Bari , Italy.

Introduction: Clear cell renal cell carcinoma (ccRCC) is a metabolic disease, of which the incidence rate is increasing worldwide. Renal carcinoma is characterized by mutations in target genes involved in metabolic pathways. Metabolic reprogramming covers different processes such as aerobic glycolysis, fatty acid metabolism, and the utilization of tryptophan, glutamine, and arginine. Read More

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http://dx.doi.org/10.1080/14737159.2019.1607729DOI Listing
April 2019
1 Read

Poor compliance with perioperative chemotherapy for resectable gastric cancer and its impact on survival.

Eur J Surg Oncol 2019 Apr 6. Epub 2019 Apr 6.

Department of Research, Netherlands Comprehensive Cancer Organisation (IKNL), Utrecht, the Netherlands.

Background: In several Western European countries it is recommended to treat gastric cancer patients with perioperative chemotherapy if they are eligible for surgery. However, little is known about its use in daily clinical practice. This study examines the use of perioperative treatment and its impact on survival in the Netherlands. Read More

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http://dx.doi.org/10.1016/j.ejso.2019.03.040DOI Listing

Are Comorbidities Associated With Overall Survival in Patients With Oral Squamous Cell Carcinoma?

J Oral Maxillofac Surg 2019 Mar 19. Epub 2019 Mar 19.

Attending Physician, Department of Clinical Oncology, Miguel Servet University Hospital, Zaragoza, Spain.

Purpose: Oral squamous cell carcinoma (OSCC) is a highly prevalent type of immunogenic cancer with a low survival rate in patients with comorbidities owing to toxic habits.

Materials And Methods: A retrospective cohort study was conducted of patients with resectable OSCC at a tertiary Spanish hospital from 2011 to 2014. The primary predictor variables were comorbidity and immune biomarkers. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02782391193027
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http://dx.doi.org/10.1016/j.joms.2019.03.007DOI Listing
March 2019
2 Reads

Prognostic role of chemotherapy-induced nausea and vomiting in recurrent ovarian cancer patients: results of an individual participant data meta-analysis in 1213.

Support Care Cancer 2019 Apr 13. Epub 2019 Apr 13.

European Competence Center for Ovarian Cancer (EKZE), Department of Gynecology, Charité - University Medicine of Berlin, Campus Virchow Klinikum, Augustenburger Platz 1, 13353, Berlin, Germany.

Background: The aim of this study was to analyze the potential impact of chemotherapy-induced nausea and vomiting (CINV) on dose reductions, discontinuation of chemotherapy, and survival.

Patients And Methods: This study was designed as individual participant data meta-analysis with the original study data of three phase II/III trials that were conducted by the North-Eastern German Society of Gynecological Oncology (NOGGO) including 1213 patients with recurrent ovarian cancer. Logistic and Cox regression analyses were used to estimate odds and hazard ratios after adjusting for age, ECOG, amount of delivered cycles, amount of recurrences, and amount of comedications and study. Read More

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http://dx.doi.org/10.1007/s00520-019-04778-1DOI Listing
April 2019
1 Read

The ERUS Curriculum for Robot-assisted Partial Nephrectomy: Structure Definition and Pilot Clinical Validation.

Eur Urol 2019 Apr 9. Epub 2019 Apr 9.

ORSI Academy, Melle, Belgium; Department of Urology, Onze Lieve Vrouw Hospital, Aalst, Belgium.

Background: No validated training program for robot-assisted partial nephrectomy (RAPN) exists.

Objective: To define the structure and provide a pilot clinical validation of a curriculum for robot-assisted partial nephrectomy (RAPN).

Design, Setting, And Participants: A modified Delphi consensus methodology involving 27 experts defined curriculum structure. Read More

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http://dx.doi.org/10.1016/j.eururo.2019.02.031DOI Listing
April 2019
2 Reads

Safety and efficacy of crizotinib in patients with advanced or metastatic ROS1-rearranged lung cancer (EUCROSS): A European phase 2 clinical trial.

J Thorac Oncol 2019 Apr 9. Epub 2019 Apr 9.

Lung Cancer Group Cologne, Department I for Internal Medicine and Center for Integrated Oncology Cologne/Bonn, University Hospital Cologne, Kerpener Str. 62, 50937 Cologne, Germany. Electronic address:

Introduction: ROS1 rearrangements are found in 1% of lung cancer patients. Therapeutic efficacy of crizotinib in this subset has been demonstrated in early phase trials in the US and East Asia. Here we present data on efficacy and safety of a prospective phase 2 trial evaluating crizotinib in European ROS1-positive patients (EUCROSS). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15560864193027
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http://dx.doi.org/10.1016/j.jtho.2019.03.020DOI Listing
April 2019
13 Reads

Pretreatment financial toxicity predicts progression-free survival following concurrent chemoradiotherapy for locally advanced non-small-cell lung cancer.

Future Oncol 2019 Apr 12. Epub 2019 Apr 12.

Department of Radiation Oncology, Albert Einstein College of Medicine & Montefiore Medical Center, Bronx, NY 10461, USA.

Aim: Financial toxicity (FT) describes patients' burden from out-of-pocket medical treatment costs. We studied associations between patient-reported pretreatment FT, socioeconomic status and clinical outcomes for locally advanced non-small-cell lung cancer (LA-NSCLC) patients.

Methods: Patients received chemoradiotherapy for locally advanced non-small-cell lung cancer and completed the European Organization for the Research and Treatment of Cancer Core Quality of Life Questionnaire (EORTC QLQ-C30) quality of life assessment before treatment. Read More

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http://dx.doi.org/10.2217/fon-2018-0874DOI Listing
April 2019
2 Reads

Seroepidemiological analysis and literature review of the prevalence of Epstein-Barr virus and herpesvirus infections in pediatric cases with non-Hodgkin lymphoma in Central Europe.

Pediatr Blood Cancer 2019 Apr 12:e27752. Epub 2019 Apr 12.

Department of Pediatric Hematology and Oncology, Justus Liebig University Giessen, Giessen, Germany.

Background: Epstein-Barr virus (EBV) is linked to a variety of malignancies; most endemic Burkitt lymphoma (BL) harbor EBV, whereas only a subset of the cases of sporadic BL is EBV positive.

Procedure: We retrospectively determined the herpesvirus seroprevalence at the time of diagnosis in pediatric non-Hodgkin lymphoma (NHL) patients enrolled in NHL-BFM (Berlin-Frankfurt-Muenster) studies. We accessed the seroepidemiological data from 1147 patients that became available during 1990-2007. Read More

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http://dx.doi.org/10.1002/pbc.27752DOI Listing
April 2019
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E-cadherin germline mutations in Māori population.

Future Oncol 2019 Apr 12. Epub 2019 Apr 12.

Division of Breast Surgery, European Institute of Oncology IRCCS, 20141 Milan, Italy.

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http://dx.doi.org/10.2217/fon-2018-0834DOI Listing
April 2019
3 Reads

Mapping EORTC-QLQ-C30 and QLQ-CR29 onto EQ-5D-5L in Colorectal Cancer Patients.

J Gastrointest Cancer 2019 Apr 12. Epub 2019 Apr 12.

Department of Health Management and Economics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

Purpose: Patient-level utility data are needed for cost-utility analysis; in oncology, however, the data are commonly gathered using disease-specific questionnaires that are often not appropriate. Present study aimed to derive an algorithm which can map the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-C30 (EORTC QLQ-C30) scales and the Colorectal Cancer-Specific Quality Of Life Questionnaire (QLQ-CR29) scales onto the EuroQoL 5-Dimension 5-Level (EQ-5D-5L) values in patients with colorectal cancer (CRC).

Methods: Using the Ordinary Least Square (OLS) model, a cross-sectional dataset of 252 patients with CRC were gathered from three academic centers of cancer treatment in Tehran in 2017. Read More

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http://link.springer.com/10.1007/s12029-019-00229-6
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http://dx.doi.org/10.1007/s12029-019-00229-6DOI Listing
April 2019
1 Read

Dawn of precision medicine on gastric cancer.

Int J Clin Oncol 2019 Apr 11. Epub 2019 Apr 11.

Department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.

Background: In recent years, a better understanding of tumor biology and molecular features of gastric cancer has been reached. It may serve as a roadmap for patient stratification and trials of targeted therapies. The apparent efficacy of PD-1 blockade might be limited to a relatively small subset of advanced gastric cancer patients. Read More

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http://dx.doi.org/10.1007/s10147-019-01441-xDOI Listing
April 2019
2 Reads

Pharmacokinetic and exploratory exposure-response analysis of pertuzumab in patients with operable HER2-positive early breast cancer in the APHINITY study.

Cancer Chemother Pharmacol 2019 Apr 11. Epub 2019 Apr 11.

Genentech, 1 DNA Way, South San Francisco, CA, 94080, USA.

Purpose: To characterize the pharmacokinetics (PK) of, and perform an exploratory exposure-response (E-R) analysis for, pertuzumab in patients with HER2-positive early breast cancer (EBC) within the APHINITY study (NCT01358877, BIG 4-11/BO25126/TOC4939G).

Methods: A previously developed pertuzumab two-compartment linear population pharmacokinetic (popPK) model was subjected to external validation to examine appropriateness for describing pertuzumab concentrations from the APHINITY study. Pharmacokinetic drug-drug interactions (DDIs) between pertuzumab, trastuzumab, and chemotherapy were assessed by comparing observed serum or plasma C, C, and AUC geometric mean ratios with 90% CIs. Read More

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http://link.springer.com/10.1007/s00280-019-03826-1
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http://dx.doi.org/10.1007/s00280-019-03826-1DOI Listing
April 2019
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Incidental diagnosis of pulmonary mycobacteriosis among patients scheduled for lung cancer surgery: results from a series of 3224 consecutive operations.

Heliyon 2019 Mar 27;5(3):e01395. Epub 2019 Mar 27.

Department of Thoracic Surgery, IRCCS European Institute of Oncology, Milan, Italy.

Background: The relation between pulmonary mycobacteriosis and lung cancer has been scrutinized for many years but the current evidence is inconsistent as some studies found an association between the two, whereas others have reported an insignificant relation.

Materials And Methods: 3224 consecutive patients undergoing elective thoracic surgery at the Department of Thoracic Surgery of a comprehensive cancer center over a four-year period were considered. Patients diagnosed with pulmonary mycobacteriosis with microbiological confirmation on their surgical specimen were further analyzed. Read More

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http://dx.doi.org/10.1016/j.heliyon.2019.e01395DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441790PMC

Combined quantitative measures of ER, PR, HER2, and KI67 provide more prognostic information than categorical combinations in luminal breast cancer.

Mod Pathol 2019 Apr 11. Epub 2019 Apr 11.

Cancer Research UK (CRUK) Cambridge Institute, University of Cambridge, Cambridge, UK.

Although most women with luminal breast cancer do well on endocrine therapy alone, some will develop fatal recurrence thereby necessitating the need to prospectively determine those for whom additional cytotoxic therapy will be beneficial. Categorical combinations of immunohistochemical measures of ER, PR, HER2, and KI67 are traditionally used to classify patients into luminal A-like and B-like subtypes for chemotherapeutic reasons, but this may lead to the loss of prognostically relevant information. Here, we compared the prognostic value of quantitative measures of these markers, combined in the IHC4-score, to categorical combinations in subtypes. Read More

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http://www.nature.com/articles/s41379-019-0270-4
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http://dx.doi.org/10.1038/s41379-019-0270-4DOI Listing
April 2019
4 Reads

Dissecting the role of H3K27 acetylation and methylation in PRC2 mediated control of cellular identity.

Nat Commun 2019 04 11;10(1):1679. Epub 2019 Apr 11.

IEO European Institute of Oncology IRCCS, Department of Experimental Oncology, Via Adamello 16, 20139, Milan, Italy.

The Polycomb repressive complexes PRC1 and PRC2 act non-redundantly at target genes to maintain transcriptional programs and ensure cellular identity. PRC2 methylates lysine 27 on histone H3 (H3K27me), while PRC1 mono-ubiquitinates histone H2A at lysine 119 (H2Aub1). Here we present engineered mouse embryonic stem cells (ESCs) targeting the PRC2 subunits EZH1 and EZH2 to discriminate between contributions of distinct H3K27 methylation states and the presence of PRC2/1 at chromatin. Read More

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http://dx.doi.org/10.1038/s41467-019-09624-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459869PMC