297,168 results match your criteria European Journal of Work and Organizational Psychology [Journal]


Integration of GWAS and brain eQTL identifies FLOT1 as a risk gene for major depressive disorder.

Neuropsychopharmacology 2019 Feb 16. Epub 2019 Feb 16.

Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, 650223, Kunming, Yunnan, China.

Major depressive disorder (MDD) is the most prevalent mental disorder that affects more than 200 million people worldwide. Recent large-scale genome-wide association studies (GWAS) have identified multiple risk variants that show robust association with MDD. Nevertheless, how the identified risk variants confer risk of MDD remains largely unknown. Read More

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http://dx.doi.org/10.1038/s41386-019-0345-4DOI Listing
February 2019
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Integrative analyses of major histocompatibility complex loci in the genome-wide association studies of major depressive disorder.

Neuropsychopharmacology 2019 Feb 16. Epub 2019 Feb 16.

Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.

Recent European genome-wide association studies (GWAS) have revealed strong statistical correlations between MDD and numerous zero-to-high linked variants in the genomic region containing major histocompatibility complex (MHC) genes (MHC region), but the underlying molecular mechanisms are still unclear. To better understand the roles of this genomic region in the neurobiology of MDD, we applied a convergent functional genomics approach to integrate GWAS data of MDD relevant biological phenotypes, gene-expression analyses results obtained from brain samples, and genetic analyses of independent Chinese MDD samples. We observed that independent MDD risk variants in the MHC region were also significantly associated with the relevant biological phenotypes in the predicted directions, including the emotional and cognitive-related phenotypes. Read More

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http://dx.doi.org/10.1038/s41386-019-0346-3DOI Listing
February 2019

Fate and removal of trace pollutants from an anion exchange spent brine during the recovery process of natural organic matter and salts.

Water Res 2019 Feb 4;154:34-44. Epub 2019 Feb 4.

University of Twente, Faculty of Science and Technology, De Horst 2, 7522LW, Enschede, the Netherlands; Oasen NV, Nieuwe Gouwe O.Z. 3, 2801 SB, Gouda, the Netherlands.

The results of this sampling campaign on pilot scale processes aim to evaluate the occurrence and behavior of trace organic micro-pollutants and metal elements during anion exchange treatment of surface water and the subsequent treatment of generated spent brine with two types of electrodialysis membrane pairs. This knowledge is relevant to assess the quality and reusability of secondary products created during brine treatment; specifically the excess of sodium chloride to be recycled onsite and the natural organic matter, mostly consisting of humic substances, which find multiple applications in the agricultural industry. This study highlights that (1) the attachment mechanism of organic micro-pollutants to anion exchange resin occurs through electrostatic interaction and the subsequent transfer through ion exchange membranes is restricted by size exclusion; and (2) the complexation of trace metals compounds with the natural organic matter partly explains their removal by anion exchange. Read More

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http://dx.doi.org/10.1016/j.watres.2019.01.042DOI Listing
February 2019

Contemporary trends of pelvic lymph node dissection at radical cystectomy for urothelial carcinoma of urinary bladder and associated cancer specific mortality and complications: comparison between octogenarian versus younger patients.

Cancer Epidemiol 2019 Feb 13;59:135-142. Epub 2019 Feb 13.

Cancer Prognostics and Health Outcomes Unit, University of Montreal Health Center, Montreal, Québec, Canada; Division of Urology, University of Montreal Hospital Center (CHUM), Montreal, Quebec, Canada.

Background: We analysed contemporary pelvic lymph node dissection (PLND) trend during radical cystectomy (RC) for urothelial carcinoma of urinary bladder (UCUB), as well as PLND association with cancer specific mortality (CSM) and complications after stratification according to octogenarian vs. younger age.

Materials And Methods: Within the SEER and NIS databases, respectively 10,427 (T2 and T3 stages) and 19,203 (all T-stages) RC patients (2004-2015) for UCUB were identified. Read More

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http://dx.doi.org/10.1016/j.canep.2019.02.002DOI Listing
February 2019

Prospective Clinical Trial Comparing Trapezial Denervation With Trapeziectomy for the Surgical Treatment of Arthritis at the Base of the Thumb.

J Surg Res 2019 Feb 13;238:144-151. Epub 2019 Feb 13.

The Pulvertaft Hand Surgery Centre, Royal Derby Hospital, Derby, United Kingdom.

Background: Trapeziectomy is considered to be the "gold standard" procedure for first carpometacarpal joint (first CMCJ) osteoarthritis. First CMCJ denervation offers the potential benefit of a shorter procedure with bone and joint preservation and swift postoperative rehabilitation. This trial aimed to compare functional outcomes, patient satisfaction, quality of life, and cost effectiveness following these treatments. Read More

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http://dx.doi.org/10.1016/j.jss.2019.01.011DOI Listing
February 2019

Role of policy in managing mined resources for construction in Europe and emerging economies.

J Environ Manage 2019 Feb 13;236:613-621. Epub 2019 Feb 13.

School of Natural and Environmental Sciences, Newcastle University, Newcastle upon Tyne, NE1 7RU, UK. Electronic address:

Rapid urbanisation, with associated housing and infrastructure demands, leads to increased mining and use of non-renewable mineral raw materials needed for the construction industry including concrete and cement. In an emerging economy, like Thailand, which is part of Association of Southeast Asian Nations (ASEAN), current environmental management policies are insufficient to reduce raw material requirements or waste from demolition by generating inputs to construction through reuse or recycling. As part of the European Union (EU), Great Britain has successfully implemented integrated policies and achieved high rates of recycled aggregates in construction (29%) and a 70% reuse and recycling target for construction and demolition (C&D) waste. Read More

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http://dx.doi.org/10.1016/j.jenvman.2018.11.141DOI Listing
February 2019

Socioeconomic differences in the associations between diabetes and hospital admission and mortality among older adults in Europe.

Econ Hum Biol 2019 Jan 17;33:89-100. Epub 2019 Jan 17.

Department of Economics and GEN, University of Cantabria. Avenue. Los Castros, s/n, Santander, CP 39005, Spain. Electronic address:

The aim of this study is to explain the trends in socioeconomic inequality and diabetes outcomes in terms of hospital admission and death in old European people. The sample includes 73,301 individuals, across 16 European countries taken from the Survey of Health, Ageing and Retirement in Europe (SHARE). People being diagnosed of diabetes were more likely to be admitted to hospital than those without diabetes, although its effect dropped after controlling for clinical and functional complications. Read More

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http://dx.doi.org/10.1016/j.ehb.2018.12.007DOI Listing
January 2019

Characterization, prognosis, and treatment of patients with metastatic lung carcinoid tumors.

J Thorac Oncol 2019 Feb 13. Epub 2019 Feb 13.

Service d'Oncologie Médicale, Groupement Hospitalier Centre, Institut de Cancérologie des Hospices Civils de Lyon, Lyon, France; University of Lyon, Université Lyon 1, France. Electronic address:

Introduction: Metastatic lung carcinoids (MLC) remain poorly characterized and no prognostic stratification exists.

Methods: We conducted a retrospective study including patients with MLC in two European expert centers. The aims were to characterize these, identify prognostic factors of survival, and effectiveness of their treatments. Read More

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http://dx.doi.org/10.1016/j.jtho.2019.02.002DOI Listing
February 2019

Toxicological assessment compilation of selected examples of raw materials for homeopathic medicinal products.

Regul Toxicol Pharmacol 2019 Feb 13. Epub 2019 Feb 13.

Federal Institute for Drugs and Medical Devices (Bundesinstitut für Arzneimittel und Medizinprodukte, BfArM), Kurt-Georg-Kiesinger-Allee 3, 53175, Bonn, Germany.

The considerable number of homeopathic medicinal products (HMP) on the German market and the staggering breadth of active substances of various origin along with the specific legal requirements of adequate safety principles posed the need to compile data on toxicologically evaluated raw materials. In line with the European regulatory framework, HMP applications must consider appropriate safety standards in analogy to conventional human medicinal products. This review presents an option for a systematic and scientifically substantiated approach for regulatory use. Read More

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http://dx.doi.org/10.1016/j.yrtph.2019.02.007DOI Listing
February 2019

Child, Mother, Father, and Teacher Beliefs About Child Academic Competence: Predicting Math and Reading Performance in European American Adolescents.

J Res Adolesc 2019 Feb 16. Epub 2019 Feb 16.

Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Public Health Service.

Beliefs about child competence in math and reading have important implications for academic performance in adolescence. However, it is unclear whether children's own beliefs are the most important predictor of their academic performance or whether parents' and teachers' beliefs about child competence influence child academic performance. We assessed mothers', fathers', teachers', and children's beliefs about European American children's (N = 189) competence in math and reading at age 10 and children's math and language performance at ages 10, 13, and 18 years. Read More

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http://dx.doi.org/10.1111/jora.12477DOI Listing
February 2019

Changes in self-concept and risk of psychotic experiences in adolescence: a longitudinal population based cohort study.

J Child Psychol Psychiatry 2019 Feb 16. Epub 2019 Feb 16.

Department of Psychiatry, Royal College of Surgeons in Ireland, Dublin 2, Ireland.

Background: Psychotic experiences (PEs) are commonly reported in adolescence and are associated with a range of negative outcomes. Few targets for intervention for PEs have been identified. One potential target is self-concept: an individual's beliefs about his/her personal attributes. Read More

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http://dx.doi.org/10.1111/jcpp.13022DOI Listing
February 2019

Balancing diversity and connectivity in multi-level governance settings for urban transformative capacity.

Authors:
Sara Borgström

Ambio 2019 Feb 15. Epub 2019 Feb 15.

Department of Sustainable Development, Environmental Science and Engineering, The Royal Institute of Technology, 100 44, Stockholm, Sweden.

Transformation towards sustainable development is about findings new ways of thinking, organising and doing to navigate wicked challenges such as climate change and urbanisation. Such challenges call for new governance modes that match the complexity of the systems to be handled, where multi-level governance and collaborative approaches have been suggested to contribute to such transformative capacity building. This in-depth, trans-disciplinary study investigates how the multi-level governance context in Stockholm, Sweden, influences the transformative capacity from the perspective of local sustainability initiatives. Read More

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http://dx.doi.org/10.1007/s13280-018-01142-1DOI Listing
February 2019

C. elegans as a Model for Synucleinopathies and Other Neurodegenerative Diseases: Tools and Techniques.

Methods Mol Biol 2019 ;1948:93-112

University of Groningen, University Medical Center Groningen, European Research Institute for the Biology of Aging, Groningen, The Netherlands.

Caenorhabditis elegans is widely used to investigate biological processes related to health and disease. Multiple C. elegans models for human neurodegenerative diseases do exist, including those expressing human α-synuclein. Read More

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http://dx.doi.org/10.1007/978-1-4939-9124-2_9DOI Listing
January 2019

Pattern of Cerebellar Atrophy in Friedreich's Ataxia-Using the SUIT Template.

Cerebellum 2019 Feb 15. Epub 2019 Feb 15.

Department of Neurology and Hertie Institute for Clinical Brain Research, Eberhard Karls University, Hoppe-Seyler-Str. 3, 72076, Tübingen, Germany.

Whole-brain voxel-based morphometry (VBM) studies revealed patterns of patchy atrophy within the cerebellum of Friedreich's ataxia patients, missing clear clinico-anatomic correlations. Studies so far are lacking an appropriate registration to the infratentorial space. To circumvent these limitations, we applied a high-resolution atlas template of the human cerebellum and brainstem (SUIT template) to characterize regional cerebellar atrophy in Friedreich's ataxia (FRDA) on 3-T MRI data. Read More

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http://dx.doi.org/10.1007/s12311-019-1008-zDOI Listing
February 2019

Just choice: a Danielsian analysis of the aims and scope of prenatal screening for fetal abnormalities.

Med Health Care Philos 2019 Feb 15. Epub 2019 Feb 15.

Department of Health, Ethics and Society, GROW School for Oncology and Developmental Biology, Faculty of Health, Medicine and Life Sciences, Maastricht University, 6200 MD, Maastricht, The Netherlands.

Developments in Non-Invasive Prenatal Testing (NIPT) and cell-free fetal DNA analysis raise the possibility that antenatal services may soon be able to support couples in non-invasively testing for, and diagnosing, an unprecedented range of genetic disorders and traits coded within their unborn child's genome. Inevitably, this has prompted debate within the bioethics literature about what screening options should be offered to couples for the purpose of reproductive choice. In relation to this problem, the European Society of Human Genetics (ESHG) and American Society of Human Genetics (ASHG) tentatively recommend that any expansion of this type of screening, as facilitated by NIPT, should be limited to serious congenital and childhood disorders. Read More

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http://dx.doi.org/10.1007/s11019-019-09888-5DOI Listing
February 2019

European association for endoscopic surgery (EAES) consensus statement on single-incision endoscopic surgery.

Surg Endosc 2019 Feb 15. Epub 2019 Feb 15.

Department of Surgery, Maastricht University Medical Center, Maastricht, The Netherlands.

Background: Laparoscopic surgery changed the management of numerous surgical conditions. It was associated with many advantages over open surgery, such as decreased postoperative pain, faster recovery, shorter hospital stay and excellent cosmesis. Since two decades single-incision endoscopic surgery (SIES) was introduced to the surgical community. Read More

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http://dx.doi.org/10.1007/s00464-019-06693-2DOI Listing
February 2019
3.256 Impact Factor

Ticks (Acari: Ixodida) on birds (Aves) migrating through the Polish Baltic coast.

Exp Appl Acarol 2019 Feb 15. Epub 2019 Feb 15.

Faculty of Biological Sciences, University of Zielona Góra, Prof. Z. Szafrana Str. 1, 65-516, Zielona Góra, Poland.

Seasonal bird (Aves) migration between breeding and wintering areas, often located on different continents, can facilitate the spreading of tick species (Acari: Ixodida) and of tick-borne pathogens. The aim of the study was to analyse the occurrence of ticks dispersed by birds migrating along the Polish Baltic coast during spring and autumn migration. Field research was conducted at the bird ringing station in Wicie, located on the middle of the Polish Baltic coast, in 2011 and 2012 during spring and autumn migration. Read More

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http://dx.doi.org/10.1007/s10493-019-00341-zDOI Listing
February 2019

[Comments on the guidelines (2018) of the European Society of Cardiology (ESC) and the European Society of Hypertension (ESH) on the management of arterial hypertension].

Internist (Berl) 2019 Feb 15. Epub 2019 Feb 15.

Institut für Klinische Pharmakologie und Toxikologie, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, und Berlin Institute of Health, Charitéplatz 1, Berlin, 10117, Deutschland.

Arterial hypertension represents one of the most frequent chronic diseases that can lead to complications, such as stroke, dementia, heart attack, heart failure and renal failure. By 2025 the number of hypertensive patients will increase to approximately 1.6 billion people worldwide. Read More

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http://dx.doi.org/10.1007/s00108-019-0576-9DOI Listing
February 2019

A computational study of Anthracyclines interacting with lipid bilayers: Correlation of membrane insertion rates, orientation effects and localisation with cytotoxicity.

Authors:
D Toroz I R Gould

Sci Rep 2019 Feb 15;9(1):2155. Epub 2019 Feb 15.

Department of Chemistry, Imperial College London, London, SW7 2AZ, UK.

Anthracyclines interact with DNA and topoisomerase II as well as with cell membranes, and it is these latter interactions that can cause an increase in their cytotoxic activity. In the present study a detailed computational analysis of the initial insertion, orientation and nature of the interaction occurring between Anthracyclines and two different lipid bilayers (unsaturated POPC and saturated DMPC) is explored through molecular dynamics (MD) simulations; four Anthracyclines: Doxorubicin (DOX), Epirubicin (EPI), Idarubicin (IDA) and Daunorubicin (DAU) were examined. The results indicate that the increased cytotoxicity of DOX, in comparison to the other three analogues, is correlated with its ability to diffuse at a faster rate into the bilayers. Read More

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http://dx.doi.org/10.1038/s41598-019-39411-yDOI Listing
February 2019

Reverse immunodynamics: a new method for identifying targets of protective immunity.

Sci Rep 2019 Feb 15;9(1):2164. Epub 2019 Feb 15.

Department of Zoology, University of Oxford, Oxford, OX1 3PS, UK.

Despite a dramatic increase in our ability to catalogue variation among pathogen genomes, we have made far fewer advances in using this information to identify targets of protective immunity. Epidemiological models predict that strong immune selection can cause antigenic variants to structure into genetically discordant sets of antigenic types (e.g. Read More

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http://dx.doi.org/10.1038/s41598-018-37288-xDOI Listing
February 2019

Multi-cohort study identifies social determinants of systemic inflammation over the life course.

Nat Commun 2019 Feb 15;10(1):773. Epub 2019 Feb 15.

LEASP, UMR 1027, Inserm-Université Toulouse III Paul Sabatier, Toulouse, 31000, France.

Chronic inflammation has been proposed as having a prominent role in the construction of social inequalities in health. Disentangling the effects of early life and adulthood social disadvantage on inflammation is key in elucidating biological mechanisms underlying socioeconomic disparities. Here we explore the relationship between socioeconomic position (SEP) across the life course and inflammation (as measured by CRP levels) in up to 23,008 participants from six European cohort studies from three countries conducted between 1958 and 2013. Read More

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http://dx.doi.org/10.1038/s41467-019-08732-xDOI Listing
February 2019

Divalent EuRhSi as a reference for the Luttinger theorem and antiferromagnetism in trivalent heavy-fermion YbRhSi.

Nat Commun 2019 Feb 15;10(1):796. Epub 2019 Feb 15.

Donostia International Physics Center (DIPC), 20080, San Sebastian, Spain.

Application of the Luttinger theorem to the Kondo lattice YbRhSi suggests that its large 4f-derived Fermi surface (FS) in the paramagnetic (PM) regime should be similar in shape and volume to that of the divalent local-moment antiferromagnet (AFM) EuRhSi in its PM regime. Here we show by angle-resolved photoemission spectroscopy that paramagnetic EuRhSi has a large FS essentially similar to the one seen in YbRhSi down to 1 K. In EuRhSi the onset of AFM order below 24. Read More

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http://dx.doi.org/10.1038/s41467-019-08688-yDOI Listing
February 2019

Mass spectrometry-based analysis of cerebrospinal fluid from arthritis patients-immune-related candidate proteins affected by TNF blocking treatment.

Arthritis Res Ther 2019 Feb 15;21(1):60. Epub 2019 Feb 15.

Rheumatology Unit, Department of Medicine, Solna, Center of Molecular Medicine (CMM), Karolinska Institutet, Karolinska University Hospital, SE-17176, Stockholm, Sweden.

Background: Signs of inflammation in cerebrospinal fluid (CSF) of rheumatoid arthritis patients correlate positively with fatigue, a central nervous system (CNS)-related symptom that can be partially suppressed by TNF blockade. This suggests a possible role for CNS inflammation in arthritis that may be affected by TNF blockade. We therefore investigated the effects of TNF blockade on the arthritis CSF proteome and how candidate proteins related to clinical measures of disease activity and inflammation. Read More

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http://dx.doi.org/10.1186/s13075-019-1846-6DOI Listing
February 2019

The feasibility of assessing frailty and sarcopenia in hospitalised older people: a comparison of commonly used tools.

BMC Geriatr 2019 Feb 15;19(1):42. Epub 2019 Feb 15.

Academic Geriatric Medicine, University of Southampton, Southampton, UK.

Background: Frailty and sarcopenia are common amongst hospitalised older people and associated with poor healthcare outcomes. Widely recognised tools for their identification are the Fried Frailty Phenotype, its self-report version the FRAIL Scale, and the European Working Group on Sarcopenia in Older People (EWGSOP) criteria. We studied the feasibility of using these tools in a hospital setting of acute wards for older people. Read More

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http://dx.doi.org/10.1186/s12877-019-1053-yDOI Listing
February 2019

Development and validation of the European QUALity (EQUAL) score for mucormycosis management in haematology.

J Antimicrob Chemother 2019 Feb 15. Epub 2019 Feb 15.

Department I for Internal Medicine, Excellence Centre for Medical Mycology (ECMM), University Hospital Cologne, Cologne, Germany.

Background: Mucormycosis is a life-threatening infection in immunocompromised patients and in haematological malignancy patients in particular.

Objectives: Our aim was to develop and evaluate a scoring tool to measure adherence to current guidelines for mucormycosis.

Methods: Current guidelines of scientific societies on mucormycosis management were reviewed. Read More

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http://dx.doi.org/10.1093/jac/dkz051DOI Listing
February 2019

Improvements cardiometabolic risk factors in Latin American Amerindians (the Mapuche) with concurrent training.

Scand J Med Sci Sports 2019 Feb 15. Epub 2019 Feb 15.

Education department of La Unión city, Chile.

Our aim was to investigate the effects of 12-weeks of CT (i.e., high-intensity interval and resistance training) in Mapuche adults from Chile and in their peers of European descent. Read More

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http://dx.doi.org/10.1111/sms.13409DOI Listing
February 2019

Sublethal Effects of the Insecticide Pyrifluquinazon on the European Honey Bee (Hymenoptera: Apidae).

J Econ Entomol 2019 Feb 16. Epub 2019 Feb 16.

Department of Entomology, Virginia Tech, Blacksburg, VA.

Pyrifluquinazon (PQZ) is an Insecticide Resistance Action Committee (IRAC) Group 9 insecticide that has recently been registered for use in the United States for control of soft-bodied sucking insect pests. Although it has been classified as practically nontoxic to honey bees, Apis mellifera L. (Hymenoptera: Apidae), based on acute contact bioassays, additional information on sublethal effects of this insecticide on honey bees is lacking. Read More

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http://dx.doi.org/10.1093/jee/toz014DOI Listing
February 2019

Establishing an updated core domain set for studies in juvenile idiopathic arthritis: a report from the OMERACT 2018 JIA Workshop.

J Rheumatol 2019 Feb 15. Epub 2019 Feb 15.

E.M. Morgan MD, Associate Professor, Division of Rheumatology, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH, J.E. Munro MBBS, Associate Professor, Head of Rheumatology at the Royal Children's Hospital, Melbourne, Australia and Group Leader Arthritis research, Murdoch Children's Research Institute Melbourne Australia, J. Horonjeff, PhD, Instructor, Office of Research, Division of Rheumatology, Columbia University Medical Center, New York, NY, B. Horgan, Consumer Advocate, Consumer and Community Health Research Network, Australia, B. Shea, PhD, Clinical Investigator, Ottawa Hospital Research Institute, Adjunct Professor, School of Epidemiology and Public Health, University of Ottawa, Ottawa, Canada, B.M. Feldman, MD, MSc, FRCPC, Professor Pediatrics, Medicine, Institute of Health Policy Management & Evaluation, University of Toronto, Head, Division of Rheumatology, The Hospital for Sick Children, Toronto, ON, H. Clairman, M.Sc., Clinical Research Project Coordinator, Child Health Evaluative Sciences, Hospital for Sick Children, Toronto ON, C.O. Bingham III, MD; Professor of Medicine, Division of Rheumatology, Johns Hopkins University, Baltimore, MD; S. Thornhill, AA, Qualitative Research Consultant, Thornhill Associates, Hermosa Beach, CA, V. Strand MD, Adjunct Clinical Professor, Division of Immunology/Rheumatology, Stanford University, Palo Alto, CA, A. Alongi, PhD Student, IRCCS Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, and Università degli studi di Genova, Genoa, Italy, S. Magni-Manzoni, M.D. Rheumatology Division, Ospedale Pediatrico Bambino Gesù, Roma, Italy, M. A.J. van Rossum, MD PhD, Pediatric Rheumatologist/Immunologist, Amsterdam Rheumatology and Immunology Center / Reade l Emma Children's Hospital Amsterdam Medical Center, Amsterdam, R. Vesely, MD, Head of the Rheumatology, Respiratory, Gastroenterology and Immunology Office Scientific and Regulatory Management Department European Medicines Agency, London, United Kingdom J. Vojinovic, MD PhD, Professor, University of Nis, Faculty of Medicine, Department of Pediatric Rheumatology, Serbia H.I. Brunner, Professor, Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, J.G. Harris, MD, Assistant Professor, Division of Rheumatology, Children's Mercy - Kansas City, Kansas City, MO, D.B. Horton, MD, MSCE, Assistant Professor, Division of Pediatric Rheumatology, Rutgers Robert Wood Johnson Medical School, Institute for Health, Health Care Policy and Aging Research, New Brunswick, NJ, D.J. Lovell, MD, Professor, Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, M. Mannion, MD, Assistant Professor of Rheumatology, University of Alabama at Birmingham, Birmingham, AL, H. Rahimi, MD, Assistant Professor, Division of Rheumatology, University of Rochester, Golisano Children's Hospital, Rochester, NY; A. Ravelli, MD, Professor of Pediatrics, Università degli Studi di Genova and IRCCS Istituto Giannina Gaslini, Genoa, Italy, S. Ringold, MD, Assistant Professor, Division of Rheumatology, Seattle Children's, Seattle, WA, Nicolino Ruperto, MD, MPH, IRCCS Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, PRINTO, Genoa, M.S. Schrandt, J.D., Director, Patient Engagement, Arthritis Foundation, Atlanta, GA, S. Shenoi, MBBS, MS Associate Professor, Seattle Children's Hospital, Seattle, WA Natalie J. Shiff, MD, University of Florida, Shands Children's Hospital, Gainesville, FL, K. Toupin-April, PhD, Associate Scientist, Children's Hospital of Eastern Ontario Research Institute, Assistant Professor, Department of Pediatrics and School of Rehabilitation Sciences, University of Ottawa, Ottawa, Canada, N. Tzaribachev, MD, Pediatric Rheumatology Research Institute, Bad Bramstedt, Germany, P. Weiss, MD, MSCE, Associate Professor, Division of Rheumatology, Children's Hospital of Philadelphia, Philadelphia, PA, A. Consolaro, MD, PhD, Assistant Professor, IRCCS Istituto Giannina Gaslini, Clinica Pediatrica e Reumatologia, and Università degli studi di Genova, Genoa, Italy, Address correspondence to: E.M. Morgan MD, Associate Professor of Pediatrics, Division of Rheumatology Cincinnati Children's Hospital Medical Center 3333 Burnet Ave, MLC 4010, Cincinnati, OH 45229; Email:

Objective: The current Juvenile Idiopathic Arthritis (JIA) Core Set used in randomized controlled trials (RCTs) and longitudinal observational studies (LOS) was developed without input of patients/parents. At OMERACT 2016, a special interest group voted to reconsider the core set incorporating broader stakeholder input. We describe subsequent work culminating in an OMERACT 2018 plenary and consensus voting. Read More

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http://dx.doi.org/10.3899/jrheum.181088DOI Listing
February 2019

Vitamin D levels and risk of delirium: A mendelian randomization study in the UK Biobank.

Neurology 2019 Feb 15. Epub 2019 Feb 15.

From the Epidemiology and Public Health Group (K.B., L.J., L.C.P., J.D., D.M.), University of Exeter Medical School, Royal Devon & Exeter Hospital, Exeter, UK; UConn Center on Aging (G.A.K., R.H.F., D.M.), University of Connecticut, Farmington, CT; and National Institute on Aging (L.F.), Baltimore, MD.

Objective: To estimate effects of vitamin D levels on incident delirium hospital admissions using inherited genetic variants in mendelian randomization models, which minimize confounding and exclude reverse causation.

Methods: Longitudinal analysis using the UK Biobank, community-based, volunteer cohort (2006-2010) with incident hospital-diagnosed delirium (ICD-10 F05) ascertained during ≤9.9 years of follow-up of hospitalization records (to early 2016). Read More

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http://dx.doi.org/10.1212/WNL.0000000000007136DOI Listing
February 2019

Patient-reported outcomes following enzalutamide or placebo in men with non-metastatic, castration-resistant prostate cancer (PROSPER): a multicentre, randomised, double-blind, phase 3 trial.

Lancet Oncol 2019 Feb 12. Epub 2019 Feb 12.

University College London Cancer Institute, London, UK.

Background: In the PROSPER trial, enzalutamide significantly improved metastasis-free survival in patients with non-metastatic, castration-resistant prostate cancer. Here, we report the results of patient-reported outcomes of this study.

Methods: In the randomised, double-blind, placebo-controlled, phase 3 PROSPER trial, done at 254 study sites worldwide, patients aged 18 years or older with non-metastatic, castration-resistant prostate cancer and a prostate-specific antigen doubling time of up to 10 months were randomly assigned (2:1) via an interactive voice web recognition system to receive oral enzalutamide (160 mg per day) or placebo. Read More

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http://dx.doi.org/10.1016/S1470-2045(18)30898-2DOI Listing
February 2019

"… the marvelous freedom to research what one finds interesting": Theodor Boveri at the Naples Zoological Station.

Mar Genomics 2019 Feb 12. Epub 2019 Feb 12.

Via Enea Zanfagna 52, 80125 Napoli, Italy. Electronic address:

In January 1888, shortly after his Habilitation (Nov. 1887), Theodor Boveri came for the first time as guest investigator to the Naples Zoological Station. The last of his eight research stays took place in spring 1914, the year before his untimely death in 1915. Read More

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http://dx.doi.org/10.1016/j.margen.2019.01.001DOI Listing
February 2019

Persistence and 4-year boosting of the bactericidal response elicited by two- and three-dose schedules of MenB-FHbp: A phase 3 extension study in adolescents.

Vaccine 2019 Feb 12. Epub 2019 Feb 12.

Pfizer Vaccine Research and Development, 500 Arcola Road, Collegeville, PA 19426, USA.

Background: The period of heightened risk of invasive meningococcal disease in adolescence extends for >10 years. This study aimed to evaluate persistence of the immune response to the serogroup B meningococcal (MenB) vaccine MenB-FHbp (Trumenba, Bivalent rLP2086) under two- and three-dose primary vaccination schedules, both of which are approved in the United States and the European Union, and to assess safety and immunogenicity of a booster dose.

Methods: This was an open-label extension study of a phase 2 randomized MenB-FHbp study (primary study). Read More

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http://dx.doi.org/10.1016/j.vaccine.2018.11.073DOI Listing
February 2019

Association between night-time surgery and occurrence of intraoperative adverse events and postoperative pulmonary complications.

Br J Anaesth 2019 Mar 8;122(3):361-369. Epub 2019 Feb 8.

Dipartimento di Scienze Chirurgiche e Diagnostiche Integrate, Università degli Studi di Genova, Genova, Italy; IRCCS Ospedale Policlinico San Martino, Genova, Italy.

Background: The aim of this post hoc analysis of a large cohort study was to evaluate the association between night-time surgery and the occurrence of intraoperative adverse events (AEs) and postoperative pulmonary complications (PPCs).

Methods: LAS VEGAS (Local Assessment of Ventilatory Management During General Anesthesia for Surgery) was a prospective international 1-week study that enrolled adult patients undergoing surgical procedures with general anaesthesia and mechanical ventilation in 146 hospitals across 29 countries. Surgeries were defined as occurring during 'daytime' when induction of anaesthesia was between 8:00 AM and 7:59 PM, and as 'night-time' when induction was between 8:00 PM and 7:59 AM. Read More

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http://dx.doi.org/10.1016/j.bja.2018.10.063DOI Listing

A Novel Rare Missense Variation of the Gene: Evidencesof Implication in Crohn's Disease.

Int J Mol Sci 2019 Feb 15;20(4). Epub 2019 Feb 15.

EA 2694-Santé Publique: épidémiologie et qualité des soins, University Lille, CHU Lille, F-59000 Lille, France.

The gene, involved in innate immune responses to bacterial peptidoglycan, has been found to be closely associated with Crohn's Disease (CD), with an Odds Ratio ranging from 3⁻36. Families with three or more CD-affected members were related to a high frequency of gene variations, such as R702W, G908R, and 1007fs, and were reported in the EPIMAD Registry. However, some rare CD multiplex families were described without identification of common linked-to-disease variations. Read More

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http://dx.doi.org/10.3390/ijms20040835DOI Listing
February 2019

Setting Policy Priorities for Front-of-Pack Health Claims and Symbols in the European Union: Expert Consensus Built by Using a Delphi Method.

Nutrients 2019 Feb 14;11(2). Epub 2019 Feb 14.

Department of Agricultural Economics, Ghent University, Coupure links 653, 9000 Ghent, Belgium.

Despite the fact that front-of-pack nutrition labels such as health claims and symbols have received growing attention in consumer behavior research, comprehensive conclusions could not yet be drawn to develop concrete policy actions, owing to the complexity of the subject and a constantly changing market environment. In this study, evidence-based policy recommendations and communication guidelines have been derived from the findings of the EU FP7 project CLYMBOL ("Role of health-related CLaims and sYMBOLs in consumer behavior", Grant Agreement 311963), and have been evaluated and prioritized by European stakeholders using a three-round Delphi method. A moderate level of consensus was achieved and results suggest that policy priority should focus on ways to improve consumer motivation and interest in healthy eating. Read More

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http://dx.doi.org/10.3390/nu11020403DOI Listing
February 2019

The Oral NOAEL of Flurochloridone in Male Wistar Rats in Ninety-Day Subchronic Toxicity Test Was 3mg/kg/day.

Int J Environ Res Public Health 2019 Feb 14;16(4). Epub 2019 Feb 14.

School of Public Health/MOE Key Laboratory for Public Health Safety/Collaborative Innovation Center of Social Risks Governance in Health, Fudan University, Shanghai 200032, China.

A ninety-day toxicity and toxicokinetics of flurochloridone (FLC) were studied in male Wistar rats with oral administration at doses of 3 mg/kg and 10 mg/kg respectively, following the previous study. Apparent toxicity to reproductive system of male rats was still observed at the dose of 10 mg/kg, trace amounts of FLC were still detected 24 hours after administration, testicular weight, epididymal weight and serum testosterone were significantly reduced and sperm abnormalities in epididymis were significantly increased. No abnormalities were found in 3 mg/kg group, it indicated that no-observed-adverse-effect level (NOAEL) of FLC in male rats was 3 mg/kg/day, far below the dose of 20 mg/kg/day reported by European Food Safety Authority (EFSA). Read More

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http://dx.doi.org/10.3390/ijerph16040553DOI Listing
February 2019

No Causal Effect of Telomere Length on Ischemic Stroke and Its Subtypes: A Mendelian Randomization Study.

Cells 2019 Feb 14;8(2). Epub 2019 Feb 14.

Beijing Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical University, Beijing 100069, China.

Background: Epidemiological studies observing inconsistent associations of telomere length (TL) with ischemic stroke (IS) are susceptible to bias according to reverse causation and residual confounding. We aimed to assess the causal association between TL, IS, and the subtypes of IS, including large artery stroke (LAS), small vessel stroke (SVS), and cardioembolic stroke (CES) by performing a series of two-sample Mendelian randomization (MR) approaches.

Methods: Seven single nucleotide polymorphisms (SNPs) were involved as candidate instrumental variables (IVs), summarized from a genome-wide meta-analysis including 37,684 participants of European descent. Read More

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http://dx.doi.org/10.3390/cells8020159DOI Listing
February 2019

The Phylogeographic Diversity of EBV and Admixed Ancestry in the Americas⁻Another Model of Disrupted Human-Pathogen Co-Evolution.

Cancers (Basel) 2019 Feb 14;11(2). Epub 2019 Feb 14.

Advanced Center for Chronic Diseases (ACCDiS), Pontificia Universidad Catolica de Chile, Santiago 8330034, Chile.

Epstein-Barr virus (EBV) is an etiological agent for gastric cancer with significant worldwide variations. Molecular characterizations of EBV have shown phylogeographical variations among healthy populations and in EBV-associated diseases, particularly the cosegregated BamHI-I fragment and XhoI restriction site of exon 1 of the gene. In the Americas, both cosegregated variants are present in EBV carriers, which aligns with the history of Asian and European human migration to this continent. Read More

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http://dx.doi.org/10.3390/cancers11020217DOI Listing
February 2019

Role of Front-of-Package Gluten-Free Product Labeling in a Pair-Matched Study in Women with and without Celiac Disease on a Gluten-Free Diet.

Nutrients 2019 Feb 14;11(2). Epub 2019 Feb 14.

Department of Organization and Consumption Economics, Faculty of Human Nutrition and Consumer Sciences, Warsaw University of Life Sciences (SGGW⁻WULS), 159C Nowoursynowska Street, 02⁻776 Warsaw, Poland.

Gluten-free (GF) product labeling is one of the most important determinants of food product choices by patients with celiac disease, due to the need for following a GF diet. The aim of this study was to assess the role of front-of-package GF product labeling in pair-matched celiac and non-celiac women on a GF diet in a choice experiment (CE). In subgroups of celiac ( = 77) and non-celiac pair-matched respondents on a GF diet, but with no gluten-related diseases diagnosed ( = 77), the influence of front-of package labeling of GF bread on the choice of products was assessed. Read More

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http://dx.doi.org/10.3390/nu11020398DOI Listing
February 2019

Examining the Walking Accessibility, Willingness, and Travel Conditions of Residents in Saudi Cities.

Int J Environ Res Public Health 2019 Feb 14;16(4). Epub 2019 Feb 14.

School of Engineering, The University of British Columbia (UBC)-Okanagan, 1137 Alumni Ave, Kelowna 1V1 1V7, BC, Canada.

Rapid urban expansion and population growth in Saudi cities over the past four decades have increased vehicular accidents and traffic congestion and have impacted the daily walking conditions of the residents. Walking has various health and environmental benefits. In North American and European countries, three factors have been found to motivate a resident to walk within their community: their accessibility to community social and business facilities, their perception and willingness, and the safety conditions of the roads and sidewalks within their community for walking. Read More

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http://dx.doi.org/10.3390/ijerph16040545DOI Listing
February 2019

[Dopamine Transporter SPECT with I-123 labelled FP-CIT (DaTSCANTM)].

Nuklearmedizin 2019 Feb 15;58(1):5-16. Epub 2019 Feb 15.

Universitätsklinikum Freiburg, Klinik für Nuklearmedizin.

The aim of the S1 guideline is to assist in establishing the indication and in performing, interpreting and reporting SPECT investigations of the dopamine transporter (DAT) with DaTSCAN. Compared to the preceding version dated from 2007 the current update considers relevant new publications, the guidelines of the European (EANM) and Society of Nuclear Medicine (SNM), and the current version of the S3 guideline of the German Society of Neurology on "Idiopathic Parkinsonsian Syndrome". In addition new technical developments are incorporated. Read More

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http://dx.doi.org/10.1055/a-0807-8137DOI Listing
February 2019

The impact of interventions by pharmacists collected in a computerised physician order entry context: a prospective observational study with a 10-year reassessment.

Swiss Med Wkly 2019 Feb 15;149:w20015. Epub 2019 Feb 15.

Pharmacy Department, Georges-Pompidou European Hospital, APHP, Paris, France / Equipe 22, Centre de Recherche des Cordeliers, UMR, INSERM, Paris, France.

Aims Of The Study: This study assesses clinical interventions by pharmacists prospectively collected from medical and surgical wards, notably the acceptance of interventions, computerised physician order entry (CPOE)related problems, the potential impact of interventions on patient safety evaluated by a multidisciplinary committee, and their evolution over the 10 years since a first assessment.

Methods: A prospective observational study covering 13 months was conducted in a French teaching hospital with a patient information system that integrates an electronic health record (EHR) with a CPOE. Interventions by pharmacists were prospectively recorded using CPOE. Read More

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http://dx.doi.org/10.4414/smw.2019.20015DOI Listing
February 2019

Ozone impact on wheat in Europe, Asia and North America - A comparison.

Sci Total Environ 2019 Feb 6;664:908-914. Epub 2019 Feb 6.

University of Gothenburg, Department of Biological and Environmental Sciences, P.O. Box 461, 40530 Gothenburg, Sweden. Electronic address:

Data from experiments where field-grown wheat was exposed to ozone were collated in order to compare the effects in Europe, Asia and North America using dose-response regression. In addition to grain yield, average grain mass and harvest index were included to reflect the influence of ozone on the crop growth pattern. In order to include as many experiments as possible, daytime average ozone concentration was used as the ozone exposure index, but AOT40, estimated from average ozone concentrations, was also used to compare the performance of the two exposure metrics. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.02.089DOI Listing
February 2019

Rapid assessment of enhanced safety surveillance for influenza vaccine.

Public Health 2019 Feb 12;168:137-141. Epub 2019 Feb 12.

Dirección General de Salud Pública, Conselleria de Sanidad Universal y Salud Pública, Valencia, Spain.

Objectives: The enhanced safety surveillance for seasonal influenza vaccines established by the European Medicines Agency is required each season. Therefore, a registry capable of rapidly detecting and evaluating potential new safety concerns is needed. The aim of the study is to demonstrate the effectiveness of the vaccine information system of the Valencia region to make a rapid assessment of the influenza vaccine safety and describe the safety of the two vaccine types used in the 2017/2018 season. Read More

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http://dx.doi.org/10.1016/j.puhe.2018.12.013DOI Listing
February 2019

Peptide vaccines in early breast cancer.

Breast 2019 Feb 7;44:128-134. Epub 2019 Feb 7.

IEO, European Institute of Oncology IRCCS, Milan Italy; University of Milan, Italy. Electronic address:

The immune system plays a dual role of host-protecting and tumor-promoting, as elegantly expressed by the 'cancer immunoediting' hypothesis. Although breast cancer has not been traditionally considered to be immunogenic, recently there is accumulating and solid evidence on the association between immune system and breast cancer. To mount an effective anti-tumor response, host immunosurveillance must recognize tumor-specific epitopes, thus defining the antigenicity of a tumor. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09609776193002
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http://dx.doi.org/10.1016/j.breast.2019.02.003DOI Listing
February 2019
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Regulating particle number measurements from the tailpipe of light-duty vehicles: The next step?

Environ Res 2019 Feb 7;172:1-9. Epub 2019 Feb 7.

European Commission, Joint Research Centre, 21027 Ispra, VA, Italy.

Light-duty vehicle emission regulation in the European Union requires the dilution of the whole exhaust in a dilution tunnel with constant volume sampling prior to emission measurements. This methodology avoids measurement uncertainties associated with direct raw exhaust emission measurements from the tailpipe, such as exhaust flow determination, exhaust flow pressure pulsations, differences in the response time between exhaust flow and instrument signals, or their misalignment. Transfer tubes connecting the tailpipe to the dilution tunnel of different lengths, and mixing of the exhaust gas with the dilution air in the dilution tunnel may increase differences in measurements performed at different facilities. Read More

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http://dx.doi.org/10.1016/j.envres.2019.02.006DOI Listing
February 2019

Species delimitation in the East Asian species of the relict tree genus Zelkova (Ulmaceae): A complex history of diversification and admixture among species.

Mol Phylogenet Evol 2019 Feb 12. Epub 2019 Feb 12.

Natural History Museum Fribourg, Chemin du Musée 6, 1700 Fribourg, Switzerland; Department of Biology and Botanic Garden, University of Fribourg, Chemin du Musée 10, 1700 Fribourg, Switzerland.

Zelkova species, trees of the elm family (Ulmaceae), are part of the Cenozoic relict flora. In western Eurasia, the genus comprises three species that are restricted to disjunct areas (Z. sicula on Sicily, Z. Read More

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http://dx.doi.org/10.1016/j.ympev.2019.02.010DOI Listing
February 2019

A systematic review of patient participation during bedside handovers on wards with older patients indicates evidence is urgently needed.

Int J Older People Nurs 2019 Feb 15:e12226. Epub 2019 Feb 15.

Strategic Policy Cell, Ghent University Hospital, Ghent, Belgium.

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http://dx.doi.org/10.1111/opn.12226DOI Listing
February 2019

Plasticity versus chronicity: Stable performance on category fluency 40 years post-onset.

J Neuropsychol 2019 Feb 15. Epub 2019 Feb 15.

Department of Psychology, Durham University, UK.

What is the long-term trajectory of semantic memory deficits in patients who have suffered structural brain damage? Memory is, per definition, a changing faculty. The traditional view is that after an initial recovery period, the mature human brain has little capacity to repair or reorganize. More recently, it has been suggested that the central nervous system may be more plastic with the ability to change in neural structure, connectivity, and function. Read More

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http://dx.doi.org/10.1111/jnp.12180DOI Listing
February 2019