302,626 results match your criteria European Journal of Work and Organizational Psychology [Journal]


Artificial Intelligence in Clinical Decision Support: Challenges for Evaluating AI and Practical Implications.

Yearb Med Inform 2019 Apr 25. Epub 2019 Apr 25.

Macquarie University, Australian Institute of Health Innovation, Sydney, Australia.

Objectives: This paper draws attention to: i) key considerations for evaluating artificial intelligence (AI) enabled clinical decision support; and ii) challenges and practical implications of AI design, development, selection, use, and ongoing surveillance.

Method: A narrative review of existing research and evaluation approaches along with expert perspectives drawn from the International Medical Informatics Association (IMIA) Working Group on Technology Assessment and Quality Development in Health Informatics and the European Federation for Medical Informatics (EFMI) Working Group for Assessment of Health Information Systems.

Results: There is a rich history and tradition of evaluating AI in healthcare. Read More

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http://dx.doi.org/10.1055/s-0039-1677903DOI Listing

Artificial Intelligence in Primary Health Care: Perceptions, Issues, and Challenges.

Yearb Med Inform 2019 Apr 25. Epub 2019 Apr 25.

Department of Clinical & Experimental Medicine, University of Surrey, Guildford, Surrey, UK.

Background: Artificial intelligence (AI) is heralded as an approach that might augment or substitute for the limited processing power of the human brain of primary health care (PHC) professionals. However, there are concerns that AI-mediated decisions may be hard to validate and challenge, or may result in rogue decisions.

Objective: To form consensus about perceptions, issues, and challenges of AI in primary care. Read More

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http://dx.doi.org/10.1055/s-0039-1677901DOI Listing

The Interplay of Knowledge Representation with Various Fields of Artificial Intelligence in Medicine.

Yearb Med Inform 2019 Apr 25. Epub 2019 Apr 25.

Associate Professor, Department of Medical Informatics, Academic Medical Center - University of Amsterdam, Amsterdam Public Health research institute, Amsterdam, The Netherlands.

Introduction: Artificial intelligence (AI) is widespread in many areas, including medicine. However, it is unclear what exactly AI encompasses. This paper aims to provide an improved understanding of medical AI and its constituent fields, and their interplay with knowledge representation (KR). Read More

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http://dx.doi.org/10.1055/s-0039-1677899DOI Listing

The relationship between initial threshold, learning, and generalization in perceptual learning.

J Vis 2019 Apr;19(4):28

Department of Cognitive Science, Central European University, Budapest, Hungary.

We investigated the origin of two previously reported general rules of perceptual learning. First, the initial discrimination thresholds and the amount of learning were found to be related through a Weber-like law. Second, increased training length negatively influenced the observer's ability to generalize the obtained knowledge to a new context. Read More

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http://dx.doi.org/10.1167/19.4.28DOI Listing

Use of toxicant sensitivity distributions (TSD) for development of exposure guidelines for risk to human health from benzene.

Environ Pollut 2019 Apr 10;250:386-396. Epub 2019 Apr 10.

School of Environment and Sciences, Griffith University, Nathan Campus, Brisbane, 4111, QLD, Australia.

This technique for setting guideline values differs from that currently used by regulatory agencies throughout the world. Data for benzene were evaluated from epidemiological studies on human populations (29 studies). Exposure durations were evaluated in terms of Long Term Exposure (LTE) and Lifetime Exposure. Read More

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http://dx.doi.org/10.1016/j.envpol.2019.04.001DOI Listing

Trophic position and individual feeding habits as drivers of differential PCB bioaccumulation in fish populations.

Sci Total Environ 2019 Apr 14;674:472-481. Epub 2019 Apr 14.

Univ. Savoie Mont-Blanc, LCME, 73000 Chambéry, France.

Despite PCBs being banned since the 1980's, some European peri-alpine lakes, and consequently their fish populations, are still contaminated by these xenobiotics. We investigated the relative contribution of physiological and trophic factors that could be implicated in fish PCB bioaccumulation in Lake Bourget (France), one of the most contaminated in Europe, by collecting Arctic char (n = 55) and European whitefish (n = 89) from 2013 to 2016. Concentrations of 7 indicator PCBs were 9-168 ng. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.04.196DOI Listing

Global phylogeography reveals the origin and the evolutionary history of the Gypsy moth (Lepidoptera, Erebidae).

Mol Phylogenet Evol 2019 Apr 22. Epub 2019 Apr 22.

Museum Witt, München, Tengstr. 33, D-80796 Munich, Germany; Biology Centre of the Czech Academy of Sciences, Institute of Entomology, Branišovská 31, CZ-370 05 České Budějovice, Czech Republic; University of South Bohemia, Faculty of Science, Branišovská 1760, CZ-370 05 České Budějovice, Czech Republic. Electronic address:

We examined the global phylogeography of gypsy moth (Lymantria dispar L.) using molecular data based on mitochondrial and nuclear genes. Populations from all biogeographic regions of the native and introduced range of L. Read More

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http://dx.doi.org/10.1016/j.ympev.2019.04.021DOI Listing

Living with roommates in a shared den: Spatial and temporal segregation among semifossorial mammals.

Behav Processes 2019 Apr 22. Epub 2019 Apr 22.

Institut de Biologia Evolutiva (CSIC-UPF), Passeig Marítim de la Barceloneta 37, 08003 Barcelona, Spain; Dipartimento di Biologia, Università degli studi di Firenze, Via Madonna del Piano 6, 50019 Sesto Fiorentino (Florence), Italy.

Positive interspecific interactions in animal communities (i.e. den sharing) have long been overlooked in animal ecology. Read More

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http://dx.doi.org/10.1016/j.beproc.2019.04.013DOI Listing

NMR for sample quality assessment in metabolomics.

N Biotechnol 2019 Apr 22. Epub 2019 Apr 22.

Center of Magnetic Resonance (CERM), University of Florence, Sesto Fiorentino FI, Italy; Department of Chemistry, University of Florence, Sesto Fiorentino FI, Italy. Electronic address:

The EU Framework 7 project SPIDIA was the occasion for development of NMR approaches to evaluate the impact of different pre-analytical treatments on the quality of biological samples dedicated to metabolomics. Systematic simulation of different pre-analytical procedures was performed on urine and blood serum and plasma. Here we review the key aspects of these studies that have led to the development of CEN technical specifications, to be translated into ISO/IS in the course of the EU Horizon 2020 project SPIDIA4P. Read More

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http://dx.doi.org/10.1016/j.nbt.2019.04.004DOI Listing

Evaluation of reproducibility of the cTnT immunoassay using quality control samples.

Clin Chim Acta 2019 Apr 22. Epub 2019 Apr 22.

Istituto di Fisiologia Clinica del CNR and CNR Spin-off QualiMedLab, Pisa, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.cca.2019.04.068DOI Listing

Biological variation of peripheral blood T-lymphocytes.

J Immunol Methods 2019 Apr 22. Epub 2019 Apr 22.

Ankara Education and Trainning Hospital, Biochemistry Department, Ankara, Turkey.

Background: Flow cytometric analysis of the lymphocyte subsets has become one of the most commonly used techniques in the routine clinical laboratory. It is frequently used in monitoring lymphocyte recovery after hematopoietic stem cell transplantation (HSCT), as well as diagnosis and treatment of acquired immunodeficiency syndrome (AIDS). Reliable biological variation (BV) data is needed for safe clinical application of these tests. Read More

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http://dx.doi.org/10.1016/j.jim.2019.04.002DOI Listing

Systemic Resilience to Cross-border Infectious Disease Threat Events in Europe.

Transbound Emerg Dis 2019 Apr 25. Epub 2019 Apr 25.

Department of Public Health and Clinical Medicine, Umeå Centre for Global Health Research & Epidemiology and Global Health Unit, Umeå University, 901 87, Umeå, Sweden.

Recurrent health emergencies threaten global health security. International Health Regulations (IHR) aim to prevent, detect and respond to such threats, through increase in national public health core capacities, but whether IHR core capacity implementation is necessary and sufficient has been contested. With a longitudinal study we relate changes in national IHR core capacities to changes in cross-border infectious disease threat events (IDTE) between 2010 and 2016, collected through epidemic intelligence at the European Centre for Disease Prevention and Control (ECDC). Read More

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http://dx.doi.org/10.1111/tbed.13211DOI Listing

Phylogeographic structure and ecological niche modelling reveal signals of isolation and postglacial colonisation in the European stag beetle.

PLoS One 2019 25;14(4):e0215860. Epub 2019 Apr 25.

Research Institute for Nature and Forest (INBO), Brussels, Belgium.

Lucanus cervus (L.), the stag beetle, is a saproxylic beetle species distributed widely across Europe. Throughout its distribution the species has exhibited pronounced declines and is widely considered threatened. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215860PLOS

Positive selection and recombination shaped the large genetic differentiation of Beet black scorch virus population.

PLoS One 2019 25;14(4):e0215574. Epub 2019 Apr 25.

Plant Virus Research Department, Iranian Research Institute of Plant Protection (IRIPP), Agricultural Research, Education and Extension Organization (AREEO), Tehran, Iran.

Beet black scorch virus (BBSV) is a species in the Betanecrovirus genus, in family Tombusviridae. BBSV infection is of considerable importance, causing economic losses to sugar beet (Beta vulgaris) field crops worldwide. Phylogenetic analyses using 3'UTR sequences divided most BBSV isolates into two main groups. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215574PLOS
April 2019
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Underreported and unknown student harassment at the Faculty of Science.

PLoS One 2019 25;14(4):e0215067. Epub 2019 Apr 25.

Gender and Diversity Committee of the Faculty of Science of the Radboud University, Nijmegen, The Netherlands.

Reports of sexual harassment at medical faculties throughout the world, including the Radboud University, raised the question how prevalent this is at the Faculty of Science. We performed a survey among students to assess their experiences with harassment. This questionnaire consisted of questions from the EGERA survey, a questionnaire held among staff of multiple European Universities. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215067PLOS

Appropriate empiric antibiotic choices in health care associated urinary tract infections in urology departments in Europe from 2006 to 2015: A Bayesian analytical approach applied in a surveillance study.

PLoS One 2019 25;14(4):e0214710. Epub 2019 Apr 25.

Institute for Clinical Medicine, Oslo University, Oslo, Norway.

Background: Health care associated urinary tract infections (HAUTI) is a common complicating factor of urological practice. It is unclear what the appropriate empirical antibiotic choices are and how infection control policies (ICP) influence this. The aim of this study is to use probabilistic approaches towards the problem. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214710PLOS

Nomograms to identify elevated blood pressure values and left ventricular hypertrophy in a paediatric population: American Academy of Pediatrics Clinical Practice vs. Fourth Report/European Society of Hypertension Guidelines.

J Hypertens 2019 Jun;37(6):1213-1222

School of Medicine and Surgery, University Milano - Bicocca.

Objective And Methods: The study aimed at evaluating, in a large sample of Italian children, the reclassification of blood pressure categories with the new U.S. nomograms, obtained in a population of normal-weight children (American Academy of Pediatrics Clinical Practice Guidelines, AAP-CPG), compared with the Fourth Report/European Society of Hypertension (ESH) nomograms. Read More

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http://dx.doi.org/10.1097/HJH.0000000000002069DOI Listing
June 2019
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Palm Oil and Beta-palmitate in Infant Formula: A Position Paper by the European Society for Paediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN) Committee on Nutrition.

J Pediatr Gastroenterol Nutr 2019 May;68(5):742-760

Department of Clinical Sciences, Pediatrics, Umeå University, Umeå, Sweden.

Background: Palm oil (PO) is used in infant formulas in order to achieve palmitic acid (PA) levels similar to those in human milk. PA in PO is esterified predominantly at the SN-1,3 position of triacylglycerol (TAG), and infant formulas are now available in which a greater proportion of PA is in the SN-2 position (typical configuration in human milk). As there are some concerns about the use of PO, we aimed to review literature on health effects of PO and SN-2-palmitate in infant formulas. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002307DOI Listing

Measurements and Monte Carlo Simulations of 241Am Activities in Three Skull Phantoms: Eurados-Ustur Collaboration.

Health Phys 2019 Apr 23. Epub 2019 Apr 23.

USTUR, United States Transuranium and Uranium Registries, College of Pharmacy, Washington State University.

An international intercomparison was organized by Working Group 7, Internal Dosimetry, of the European Radiation Dosimetry Group in collaboration with Working Group 6, Computational Dosimetry, for measurement and Monte Carlo simulation of Am in three skull phantoms. The main objectives of this combined exercise were (1) comparison of the results of counting efficiency in fixed positions over each head phantom using different germanium detector systems, (2) calculation of the activity of Am in the skulls, (3) comparison of Monte Carlo simulations with measurements (spectrum and counting efficiency), and (4) comparison of phantom performance. This initiative collected knowledge on equipment, detector arrangements, calibration procedures, and phantoms used around the world for in vivo monitoring of Am in exposed persons, as well as on the Monte Carlo skills and tools of participants. Read More

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http://dx.doi.org/10.1097/HP.0000000000001080DOI Listing

Ultrasound assessment of gastric emptying time in preterm infants: A prospective observational study.

Eur J Anaesthesiol 2019 Apr 23. Epub 2019 Apr 23.

Christiane Beck and Lars Witt contributed equally to the article and share responsibility as first author.

Background: In paediatric anaesthesia, pre-operative fasting should be short to prevent discomfort, hunger, thirst and metabolic disorders. Current European guidelines recommend pre-operative fasting times of 4 h for breast milk and 6 h for formula milk in infants, whereas some national guidelines allow both until 4 h before anaesthesia.

Objective: We evaluated the gastric emptying times of preterm infants after breast milk and formula milk, hypothesising that the mean gastric emptying time would be less than 4 h. Read More

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http://dx.doi.org/10.1097/EJA.0000000000001007DOI Listing

Catechol-O-methyltransferase polymorphism Val158Met is associated with distal neuropathic pain in HIV-associated sensory neuropathy.

AIDS 2019 Apr 22. Epub 2019 Apr 22.

University of California, San Diego, 200 W Arbor Dr, San Diego, CA 92103.

Background: Many of those aging with HIV suffer from distal neuropathic pain (DNP) due to HIV-associated sensory neuropathy (HIV-SN). Prior studies have linked chronic pain conditions to a variant of the catechol-O-methyltransferase (COMT), ValMet. This variant confers reduced enzymatic activity and results in higher synaptic dopamine levels. Read More

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http://dx.doi.org/10.1097/QAD.0000000000002240DOI Listing

The European Council on Chiropractic Education identification of critical standards to accredit chiropractic programs: a qualitative study and thematic analysis.

J Chiropr Educ 2019 Apr 25. Epub 2019 Apr 25.

Objective: The objectives for this project were to: (1) identify and agree upon "critical standards" that must be "fully" or "substantially compliant" for a maximum 8-year reaccreditation, (2) compare recent compliance for each critical standard for all accredited programs, and (3) identify which standards have lower compliance levels compared to others.

Methods: This qualitative study uses thematic analysis. The 37 European Council on Chiropractic Education (ECCE) standards were assessed by the Quality Assurance Committee (QAC) to identify "critical standards" requiring "fully" or "substantially compliant" ratings for the maximum 8-year accreditation time period. Read More

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http://dx.doi.org/10.7899/JCE-18-21DOI Listing

Evaluation of variants in IL6R, TLR3, and DC-SIGN genes associated with dengue in sampled Colombian population.

Biomedica 2019 Mar 31;39(1):88-101. Epub 2019 Mar 31.

Laboratorio de Genética Molecular, Universidad de Antioquia, Medellín, Colombia; Grupo de Investigación en Ciencias Básicas Aplicadas, Tecnológico de Antioquia, Medellín, Colombia.

Introduction: Host genetics is recognized as an influential factor for the development of dengue disease.

Objective: This study evaluated the association of dengue with the polymorphisms rs8192284 for gene IL6R, rs3775290 for TLR3, and rs7248637 for DC-SIGN.

Materials And Methods: Of the 292 surveyed subjects, 191 were confirmed for dengue fever and the remaining 101 were included as controls. Read More

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http://dx.doi.org/10.7705/biomedica.v39i1.4029DOI Listing

Consistency and reproducibility of next-generation sequencing in cytopathology: A second worldwide ring trial study on improved cytological molecular reference specimens.

Cancer Cytopathol 2019 Apr 25. Epub 2019 Apr 25.

Department of Public Health, University of Naples Federico II, Naples, Italy.

Background: Artificial genomic reference standards in a cytocentrifuge/cytospin format with well-annotated genomic data are useful for validating next-generation sequencing (NGS) on routine cytopreparations. Here, reference standards were optimized to be stained by different laboratories before DNA extraction and to contain a lower number of cells (2 × 10 ). This was done to better reflect the clinical challenge of working with insufficient cytological material. Read More

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http://dx.doi.org/10.1002/cncy.22134DOI Listing

Fungal evolution: major ecological adaptations and evolutionary transitions.

Biol Rev Camb Philos Soc 2019 Apr 25. Epub 2019 Apr 25.

Department of Genomics and Bioinformatics, Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr. Aiguader 88, Barcelona, 08003, Spain.

Fungi are a highly diverse group of heterotrophic eukaryotes characterized by the absence of phagotrophy and the presence of a chitinous cell wall. While unicellular fungi are far from rare, part of the evolutionary success of the group resides in their ability to grow indefinitely as a cylindrical multinucleated cell (hypha). Armed with these morphological traits and with an extremely high metabolical diversity, fungi have conquered numerous ecological niches and have shaped a whole world of interactions with other living organisms. Read More

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http://dx.doi.org/10.1111/brv.12510DOI Listing

A report from a workshop of the International Stem Cell Banking Initiative, held in collaboration GAiT and the Harvard Stem Cell Institute, Boston 2017.

Stem Cells 2019 Apr 25. Epub 2019 Apr 25.

International Stem Cell Banking Initiative, 2 High St, Barley, Hertfordshire, SG88HZ, UK.

This report summarizes the recent activity of the International Stem Cell Banking Initiative (ISCBI) held at Harvard Stem Cell Institute, Boston, USA, on 18th Jun 2017. In this meeting, we aimed to find consensus on ongoing issues of quality control (QC), safety and efficacy of human pluripotent stem cell (hPSC) banks and their derivative cell therapy products for the global harmonization. In particular, assays for the QC testing such as pluripotency assays test and general QC testing criteria was intensively discussed. Read More

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http://dx.doi.org/10.1002/stem.3003DOI Listing

Core Health Outcomes in Childhood Epilepsy (CHOICE): Development of a core outcome set using systematic review methods and a Delphi survey consensus.

Epilepsia 2019 Apr 25. Epub 2019 Apr 25.

University of Exeter Medical School, College of Medicine and Health, University of Exeter, Exeter, UK.

Objective: Establishing a core set of outcomes to be evaluated and reported in intervention trials aims to improve the usefulness of health research. There is no established core outcome set (COS) for childhood epilepsies. The aim of this study was to select a COS to be used in evaluative research of interventions for children with rolandic epilepsy (RE). Read More

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http://dx.doi.org/10.1111/epi.14735DOI Listing

Early childhood child care and disruptive behavior problems during adolescence: a 17-year population-based propensity score study.

J Child Psychol Psychiatry 2019 Apr 25. Epub 2019 Apr 25.

Bordeaux Population Health Research Centre, INSERM U1219, University of Bordeaux, Bordeaux, France.

Background: Child-care services during early childhood provide opportunities for social interactions that may facilitate children's learning of acceptable social behaviors. Furthermore, they may reduce exposure to family adversity for some children. The aim of this study was to determine whether intensity of exposure to child-care services prior to age 5 years has a beneficial effect on disruptive behavior problems during adolescence, and whether the effect is more pronounced for children from low socioeconomic families. Read More

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http://dx.doi.org/10.1111/jcpp.13065DOI Listing

Evolving Regulatory Landscape for Genome-Edited Plants.

Authors:
Lisa Zannoni

CRISPR J 2019 Feb;2:3-8

Zannoni and Associates Consulting LLC, Raleigh, North Carolina.

New plant breeding innovations, including CRISPR-mediated genome editing, are enhancing the development of new plant varieties, many of which are on the cusp of entering market places internationally. The lack of clear and consistent regulatory policies globally for genome-edited plants, and their products, may limit the adoption and commercialization of these products; In contrast to the positive trends of regulatory agencies in Argentina, Brazil, Colombia, Chile, and the United States, which are at the forefront of a wave of countries that are implementing policies facilitating the development of genome-edited plants, the European Union has adopted a more restrictive approach that considers any new mutagenesis technique developed after 2001 as subject to regulation as genetically modified plants. Read More

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http://dx.doi.org/10.1089/crispr.2018.0016DOI Listing
February 2019

Cumulative probabilistic risk assessment of triazole pesticides in Belgium from 2011-2014.

Food Addit Contam Part A Chem Anal Control Expo Risk Assess 2019 Apr 25:1-11. Epub 2019 Apr 25.

a Department of Plant and Crops , Laboratory for Crop Protection Chemistry , Ghent , Belgium.

Pesticide residues in food can lead to harmful toxic effects when exposed. Some of these compounds have a common Mode of Action and thus elicit a similar biological response. This paper considers the triazoles, a class of widely used fungicides exhibiting the same short-term (acute) and long-term (chronic) response in humans. Read More

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https://www.tandfonline.com/doi/full/10.1080/19440049.2019.1
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http://dx.doi.org/10.1080/19440049.2019.1606943DOI Listing
April 2019
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Intrusive memories and voluntary memory of a trauma film: Differential effects of a cognitive interference task after encoding.

J Exp Psychol Gen 2019 Apr 25. Epub 2019 Apr 25.

Medical Research Council Cognition and Brain Sciences Unit.

Methods to reduce intrusive memories (e.g., of traumatic events) should ideally spare voluntary memory for the same event (e. Read More

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http://dx.doi.org/10.1037/xge0000598DOI Listing

Impact of white matter hyperintensity location on depressive symptoms in memory-clinic patients: a lesion–symptom mapping study

J Psychiatry Neurosci 2019 Apr 25;44(3):1-10. Epub 2019 Apr 25.

From the Alzheimer Centre Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands (Leeuwis, Hooghiemstra, Prins, Scheltens, van der Flier); the Department of Neurology, Brain Centre Rudolf Magnus, University Medical Centre Utrecht, Utrecht, the Netherlands (Weaver, Biesbroek, Exalto, Biessels); the Image Sciences Institute, University Medical Centre Utrecht, Utrecht, the Netherlands (Kuijf); the Department of Medical Humanities, Amsterdam Public Health Research Institute, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands (Hooghiemstra); the Institutes of Neurology and Healthcare Engineering, UCL, London, United Kingdom (Barkhof); the Department of Radiology and Nuclear Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands (Barkhof); and the Department of Epidemiology & Biostatistics, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands (Flier).

Background: We investigated the association between white matter hyperintensity location and depressive symptoms in a memoryclinic population using lesion–symptom mapping.

Methods: We included 680 patients with vascular brain injury from the TRACE-VCI cohort (mean age ± standard deviation: 67 ± 8 years; 52% female): 168 patients with subjective cognitive decline, 164 with mild cognitive impairment and 348 with dementia. We assessed depressive symptoms using the Geriatric Depression Scale. Read More

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http://dx.doi.org/10.1503/jpn.180136DOI Listing

MHC class I polymorphic Alu insertion (POALIN) allele and haplotype frequencies in the Arabs of the United Arab Emirates and other world populations.

Int J Immunogenet 2019 Apr 25. Epub 2019 Apr 25.

Center for Biotechnology, Khalifa University of Science and Technology, Abu Dhabi, United Arab Emirates.

Polymorphic Alu insertions (POALINs) are found throughout the human genome and have been used in various studies to infer geographic origin of human populations. The main aim of this study was to determine the allele and haplotype frequencies of five POALINs, AluHF, AluHG, AluHJ, AluTF and AluMICB, within the major histocompatibility complex (MHC) class I region of 95 UAE Arabs, and correlate their frequencies to those of the HLA-A, HLA-C and HLA-B class I allele lineages. Evolutionary relationships between the POALINs of the Arabs and those previously studied in populations of African, Asian and European descent were compared. Read More

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http://dx.doi.org/10.1111/iji.12426DOI Listing
April 2019
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Extensive validation study of the Parkinson's Disease Composite Scale.

Eur J Neurol 2019 Apr 25. Epub 2019 Apr 25.

University and Institute for Research and Medical Care IRCCS San Raffaele, Roma, Italy.

Background: A composite instrument able to rapidly and reliably assess the most relevant motor and non-motor afflictions suffered by Parkinson's disease (PD) patients in a real world clinic setting is an unmet need. The recently-validated PD Composite Scale (PDCS) was designed to fulfill this gap as a quick, comprehensive PD assessment.

Objective: Extensive evaluation of the PDCS's clinimetric properties using a large international sample. Read More

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http://dx.doi.org/10.1111/ene.13976DOI Listing

The micropolitics of choice in Italy: How the law affects lesbian and bisexual women's daily life.

J Lesbian Stud 2019 Apr 25:1-21. Epub 2019 Apr 25.

a CES-Centro de Estudos Sociais, University of Coimbra , Coimbra , Portugal.

This article stems from three years of fieldwork (2015-2017) in the context of a five-year-long, European-Research-Council-funded research project called INTIMATE-Citizenship, Care and Choice: The Micropolitics of Intimacy in Southern Europe, a comparative qualitative study that involves three countries (Italy, Portugal, and Spain) and studies intimate citizenship and the micropolitics of daily life of LGBTQ people. The article focuses specifically on the Italian case and shows how non-heterosexual women deal with the scarce legislative protection Italy grants. Our aim is to reflect upon the reciprocal influence of different axes from public and private spaces and on how they impact the micropolitics and the daily choices of our lesbian, bisexual, and pansexual participants. Read More

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http://dx.doi.org/10.1080/10894160.2019.1598719DOI Listing

Peptone-mediated glucagon-like peptide-1 secretion depends on intestinal absorption and activation of basolaterally located Calcium-Sensing Receptors.

Physiol Rep 2019 Apr;7(8):e14056

Department of Biomedical Sciences, NNF Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Protein intake robustly stimulates the secretion of the incretin hormone, glucagon-like peptide-1 (GLP-1) but the molecular mechanisms involved are not well understood. In particular, it is unknown whether proteins stimulate secretion by activation of luminal or basolateral sensors. We characterized the mechanisms using a physiologically relevant model - the isolated perfused proximal rat small intestine. Read More

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http://dx.doi.org/10.14814/phy2.14056DOI Listing

Association of meal and snack patterns with micronutrient intakes among Greek children and adolescents: data from the Hellenic National Nutrition and Health Survey.

J Hum Nutr Diet 2019 Apr 24. Epub 2019 Apr 24.

Department of Food Science and Human Nutrition, Agricultural University of Athens, Athens, Greece.

Background: The present study aimed to examine how different meal and snack patterns are associated with micronutrient intakes and diet quality among a nationally representative sample of Greek children and adolescents aged 1-19 years from the cross-sectional Hellenic National Nutrition and Health Survey (n = 598).

Methods: Meal and snack patterns were derived using 24-h dietary recalls. Mean adequacy ratio (MAR) was used as an overall measure of diet quality. Read More

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http://dx.doi.org/10.1111/jhn.12639DOI Listing

Self-reported health, healthcare service use and health-related needs: A comparison of older and younger homeless people.

Health Soc Care Community 2019 Apr 25. Epub 2019 Apr 25.

IVO Addiction Research Institute, The Hague, the Netherlands.

The number of older homeless people with a limited life expectancy is increasing. European studies on their health-related characteristics are lacking. This study compared self-reported health, healthcare service use and health-related needs of older and younger homeless people in the Netherlands. Read More

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http://dx.doi.org/10.1111/hsc.12739DOI Listing

AbRSA: A robust tool for antibody numbering.

Protein Sci 2019 Apr 24. Epub 2019 Apr 24.

Center of Growth, Metabolism and Aging, Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu 610065, PR China.

The remarkable progress in cancer immunotherapy in recent years has led to the heat of great development for therapeutic antibodies. Antibody numbering, which standardizes a residue index at each position of an antibody variable domain, is an important step in immunoinformatic analysis. It provides an equivalent index for the comparison of sequences or structures, which is particularly valuable for antibody modeling and engineering. Read More

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http://dx.doi.org/10.1002/pro.3633DOI Listing

Health indicators and contaminant levels of a critically endangered species in the Gironde estuary, the European sturgeon.

Environ Sci Pollut Res Int 2019 Apr 24. Epub 2019 Apr 24.

University of Bordeaux, UMR 5805 EPOC, Aquatic Ecotoxicology, B2, allée Geoffroy Saint-Hilaire, F-33405, Talence, France.

The European sturgeon, Acipenser sturio, is a highly endangered species that almost disappeared in the last decades. Thanks to yearly restocking of the population, this species is still found in the Gironde estuary (France), where juveniles grow during several years before leaving to the ocean. The aims of this study were to evaluate the pressure exerted on these fish by known organic and inorganic contaminants during their stay at the Gironde estuary, and to get information on the fish's health in this context. Read More

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http://dx.doi.org/10.1007/s11356-019-05139-5DOI Listing

Surface ozone in the Doon Valley of the Himalayan foothills during spring.

Environ Sci Pollut Res Int 2019 Apr 24. Epub 2019 Apr 24.

Space Physics Laboratory, Vikram Sarabhai Space Centre, Thiruvananthapuram, India.

Elevated ozone (O) pollution is observed every spring over the Northern Indian region including the Himalayan foothills, with a maximum typically in the month of May. However, studies investigating influences of photochemistry and dynamics in the valleys of Central Himalaya are limited. Here, in situ surface O observations conducted at Dehradun (77. Read More

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http://dx.doi.org/10.1007/s11356-019-05085-2DOI Listing

[Echocardiographic emergency diagnostics].

Herz 2019 Apr 24. Epub 2019 Apr 24.

Klinik und Poliklinik für Kardiologie, Universitätsklinikum Leipzig, Liebigstraße 20, 04103, Leipzig, Deutschland.

Echocardiography is a non-invasive, versatile imaging modality for the diagnostics and monitoring of life-threatening cardiac diseases. This article summarizes the currently valid recommendations on emergency echocardiography of the German Cardiac Society and the European Association of Cardiovascular Imaging and provides practical guidance for their implementation in emergency medicine. Echocardiography is especially important for the diagnostics of acute coronary syndrome and its potential complications, of pulmonary embolism and endocarditis as well as the differential diagnosis of patients in shock and in emergencies. Read More

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http://dx.doi.org/10.1007/s00059-019-4799-2DOI Listing

Visualizing the coordination-spheres of photoexcited transition metal complexes with ultrafast hard X-rays.

Phys Chem Chem Phys 2019 Apr 25. Epub 2019 Apr 25.

ELI-ALPS, ELI-HU Non-Profit Ltd., Dugonics ter 13, Szeged 6720, Hungary and Attosecond Science Group, Deutsches Elektronen Synchrotron (DESY), Notkestrasse 85, D-22607 Hamburg, Germany.

The concept of coordination sphere (CS) is central to the rational development of hierarchical molecular assemblies in modern chemistry. Manipulating the organization around transition metal ions with covalent and supramolecular interactions is a general strategy that underlies most synthetic protocols. Achieving similar control for photoexcited molecular complexes is necessary to advance the design of light-driven functionalities. Read More

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http://dx.doi.org/10.1039/c9cp01263jDOI Listing

Reversal of pulmonary arterial hypertension in POEMS syndrome with thalidomide: a case report.

Eur Heart J Case Rep 2018 Jun 27;2(2):yty051. Epub 2018 Apr 27.

Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan.

Introduction: Pulmonary arterial hypertension (PAH) is a progressive and life-threatening disease characterized by the remodelling of distal pulmonary arteries in the absence of other cardiopulmonary disease, usually leading to right ventricular failure. Given the current European Society of Cardiology and the European Respiratory Society guidelines for the diagnosis and treatment of pulmonary hypertension (PH), most of the patients with severe PAH usually require to have a lifelong combination therapy that includes prostacyclin, phosphodiesterase-5 inhibitor, and endothelin receptor antagonist. However, the reversibility of PAH has been reported through the treatment of the underlying diseases or comorbidities. Read More

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https://academic.oup.com/ehjcr/article/doi/10.1093/ehjcr/yty
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http://dx.doi.org/10.1093/ehjcr/yty051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6177100PMC
June 2018
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Analysis of Nationwide Data to Determine the Incidence and Diagnosed Prevalence of Autosomal Dominant Polycystic Kidney Disease in the USA: 2013-2015.

Kidney Dis (Basel) 2019 Mar 9;5(2):107-117. Epub 2019 Jan 9.

Otsuka Pharmaceutical Development and Commercialization, Inc., Princeton, New Jersey, USA.

Background: This study addresses an important gap, as it is the first US nationwide, epidemiologic study of ADPKD incidence and prevalence.

Summary: This 3-year, observational study utilized data from Truven Health MarketScan® administrative claims, as well as cross-sectional data from the National Ambulatory Medical Care Survey (NAMCS). We estimated the annual incidence and diagnosed prevalence using population-based data on over 170 million de-identified patients to provide the most current epidemiologic estimates available. Read More

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http://dx.doi.org/10.1159/000494923DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465773PMC

Young GI angle: New starter GI residents.

United European Gastroenterol J 2019 Apr 29;7(3):453-454. Epub 2019 Mar 29.

Department of Gastroenterology, Queen Elizabeth Hospital Birmingham, Birmingham, UK.

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http://dx.doi.org/10.1177/2050640619833555DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466743PMC

Timing of endoscopy for acute upper gastrointestinal bleeding in North West England: Results from a multicentre trainee-led network.

United European Gastroenterol J 2019 Apr 2;7(3):451-452. Epub 2019 Feb 2.

Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester, UK Rahul Kalla, Wadiamu Gashau, Simon Borg-Bartolo, Liam Morris, Kirsty Nixon, Beth Miller, Tom Barnes, Bex Cox, Elizabeth Ratcliffe, Francis Egbuonu, Johannah Cook, Ben Crooks, Scott Healey, Joe Fiske, Guarev Nigam, Kath White, Dipesh Vasant, Joe Ingoe, Adam Hamdi, Maleek Sado, Katherine Martin, Michael Finegan, Mohamed Shibeika and Rizwan Diyar.

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http://dx.doi.org/10.1177/2050640619828214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466751PMC

A call to arms for change: The UK strategy to improve standards of care in acute upper gastrointestinal bleeding.

United European Gastroenterol J 2019 Apr 2;7(3):449-450. Epub 2019 Feb 2.

Acute Upper Gastrointestinal Bleeding Endoscopy Quality Improvement Project Lead, British Society of Gastroenterology, London, UK.

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http://dx.doi.org/10.1177/2050640619828216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466746PMC

The compliance rate for the second diagnostic evaluation after a positive fecal occult blood test: A systematic review and meta-analysis.

United European Gastroenterol J 2019 Apr 6;7(3):424-448. Epub 2019 Feb 6.

Division of Gastroenterology, Rabin Medical Center, Beilinson Hospital, Petach Tikva, Israel.

Introduction: Only a minority of patients with a positive fecal occult blood test (FOBT) undergo a follow-up second diagnostic procedure, thus minimizing its contribution for colorectal cancer (CRC) prevention. We aimed to obtain a precise estimation of this problem and also assess the diagnostic yield of CRC and adenomas by colonoscopy in these patients.

Methods: Literature searches were conducted for "compliance" OR "adherence" AND "fecal occult blood test" OR "fecal immunohistochemical test" AND "colonoscopy. Read More

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http://dx.doi.org/10.1177/2050640619828185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466749PMC