1,805 results match your criteria European Journal of Psychotherapy & Counselling [Journal]


Pattern of Cerebellar Atrophy in Friedreich's Ataxia-Using the SUIT Template.

Cerebellum 2019 Feb 15. Epub 2019 Feb 15.

Department of Neurology and Hertie Institute for Clinical Brain Research, Eberhard Karls University, Hoppe-Seyler-Str. 3, 72076, Tübingen, Germany.

Whole-brain voxel-based morphometry (VBM) studies revealed patterns of patchy atrophy within the cerebellum of Friedreich's ataxia patients, missing clear clinico-anatomic correlations. Studies so far are lacking an appropriate registration to the infratentorial space. To circumvent these limitations, we applied a high-resolution atlas template of the human cerebellum and brainstem (SUIT template) to characterize regional cerebellar atrophy in Friedreich's ataxia (FRDA) on 3-T MRI data. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12311-019-1008-zDOI Listing
February 2019

Age-related Disturbances in DNA (hydroxy)methylation in APP/PS1 Mice.

Transl Neurosci 2018 31;9:190-202. Epub 2018 Dec 31.

School for Mental Health and Neuroscience (MHeNS), Department of Psychiatry and Neuropsychology, Faculty of Health, Medicine and Life Sciences, European Graduate School of Neuroscience (EURON), Maastricht University Medical Centre, Maastricht, The Netherlands.

Brain aging has been associated with aberrant DNA methylation patterns, and changes in the levels of DNA methylation and associated markers have been observed in the brains of Alzheimer's disease (AD) patients. DNA hydroxymethylation, however, has been sparsely investigated in aging and AD. We have previously reported robust decreases in 5-methylcytosine (5-mC) and 5-hydroxymethylcytosine (5-hmC) in the hippocampus of AD patients compared to non-demented controls. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1515/tnsci-2018-0028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368665PMC
December 2018

Genome-wide association scan identifies new variants associated with a cognitive predictor of dyslexia.

Transl Psychiatry 2019 Feb 11;9(1):77. Epub 2019 Feb 11.

Department of Child and Adolescent Psychiatry, Psychosomatic, and Psychotherapy, Ludwig-Maximilians University, Munich, Germany.

Developmental dyslexia (DD) is one of the most prevalent learning disorders, with high impact on school and psychosocial development and high comorbidity with conditions like attention-deficit hyperactivity disorder (ADHD), depression, and anxiety. DD is characterized by deficits in different cognitive skills, including word reading, spelling, rapid naming, and phonology. To investigate the genetic basis of DD, we conducted a genome-wide association study (GWAS) of these skills within one of the largest studies available, including nine cohorts of reading-impaired and typically developing children of European ancestry (N = 2562-3468). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41398-019-0402-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370792PMC
February 2019
1 Read

Modern health worries: Deriving two measurement invariant short scales for cross-cultural research with Ant Colony Optimization.

PLoS One 2019 7;14(2):e0211819. Epub 2019 Feb 7.

Institute of Health Promotion and Sport Sciences, ELTE Eötvös Loránd University, Budapest, Hungary.

Worries about possible harmful effects of new technologies (modern health worries) have intensely been investigated in the last decade. However, the comparability of translated self-report measures across countries is often problematic. This study aimed to overcome this problem by developing psychometrically sound brief versions of the widely used 25-item Modern Health Worries Scale (MHWS) suitable for multi-country use. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211819PLOS
February 2019

Widespread microglial activation in multiple system atrophy.

Mov Disord 2019 Feb 6. Epub 2019 Feb 6.

Departments of Nulcear Medicine and Geriatric Medicine, University Hospital Essen, Germany.

Background: The pattern and role of microglial activation in multiple system atrophy is largely unclear. The objective of this study was to use [ C](R)-PK11195 PET to determine the extent and correlation of activated microglia with clinical parameters in MSA patients.

Methods: Fourteen patients with the parkinsonian phenotype of MSA (MSA-P) with a mean disease duration of 2. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/mds.27620DOI Listing
February 2019
1 Read

Prevalence of burnout among German general practitioners: Comparison of physicians working in solo and group practices.

PLoS One 2019 6;14(2):e0211223. Epub 2019 Feb 6.

Institute of General Practice and Family Medicine, University of Bonn, Bonn, Germany.

Background: Studies from general practitioner (GP) populations from various European countries show a high prevalence of burnout, yet data from Germany are scarce and there are no data comparing GPs from solo versus group practices.

Methods: This cross-sectional survey addressed all GPs from a German network of family medicine practices comprising 185 practices. Participants were asked to fill in a self-administered questionnaire addressing socio-demographic and job-related characteristics. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211223PLOS
February 2019
4 Reads

Altered Connectivity Between Cerebellum, Visual, and Sensory-Motor Networks in Autism Spectrum Disorder: Results from the EU-AIMS Longitudinal European Autism Project.

Biol Psychiatry Cogn Neurosci Neuroimaging 2018 Dec 5. Epub 2018 Dec 5.

Department of Cognitive Neuroscience, Radboud University Medical Center, the Netherlands; Donders Institute for Brain, Cognition, and Behavior, Radboud University, the Netherlands; Karakter Child and Adolescent Psychiatry University Centre, Nijmegen, the Netherlands.

Background: Resting-state functional magnetic resonance imaging-based studies on functional connectivity in autism spectrum disorder (ASD) have generated inconsistent results. Interpretation of findings is further hampered by small samples and a focus on a limited number of networks, with networks underlying sensory processing being largely underexamined. We aimed to comprehensively characterize ASD-related alterations within and between 20 well-characterized resting-state networks using baseline data from the EU-AIMS (European Autism Interventions-A Multicentre Study for Developing New Medications) Longitudinal European Autism Project. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S24519022183030
Publisher Site
http://dx.doi.org/10.1016/j.bpsc.2018.11.010DOI Listing
December 2018
2 Reads

Cardiovascular risk algorithms in primary care: Results from the DETECT study.

Sci Rep 2019 Jan 31;9(1):1101. Epub 2019 Jan 31.

University of Heidelberg, Mannheim Medical Faculty, Department of Internal Medicine V (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Mannheim, Germany.

Guidelines for prevention of cardiovascular diseases use risk scores to guide the intensity of treatment. A comparison of these scores in a German population has not been performed. We have evaluated the correlation, discrimination and calibration of ten commonly used risk equations in primary care in 4044 participants of the DETECT (Diabetes and Cardiovascular Risk Evaluation: Targets and Essential Data for Commitment of Treatment) study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-018-37092-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355969PMC
January 2019

Transethnic meta-analysis of rare coding variants in PLCG2, ABI3, and TREM2 supports their general contribution to Alzheimer's disease.

Transl Psychiatry 2019 Jan 31;9(1):55. Epub 2019 Jan 31.

Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, University of Cologne, 50937, Cologne, Germany.

Rare coding variants in TREM2, PLCG2, and ABI3 were recently associated with the susceptibility to Alzheimer's disease (AD) in Caucasians. Frequencies and AD-associated effects of variants differ across ethnicities. To start filling the gap on AD genetics in South America and assess the impact of these variants across ethnicity, we studied these variants in Argentinian population in association with ancestry. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41398-019-0394-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355764PMC
January 2019
2 Reads
4.360 Impact Factor

FDG-PET underscores the key role of the thalamus in frontotemporal lobar degeneration caused by C9ORF72 mutations.

Transl Psychiatry 2019 Jan 31;9(1):54. Epub 2019 Jan 31.

Department of Psychiatry, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.

C9ORF72 mutations are the most common cause of familial frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). MRI studies have investigated structural changes in C9ORF72-associated FTLD (C9FTLD) and provided first insights about a prominent involvement of the thalamus and the cerebellum. Our multicenter, F-fluorodeoxyglucose positron-emission tomography study of 22 mutation carriers with FTLD, 22 matched non-carriers with FTLD, and 23 cognitively healthy controls provided valuable insights into functional changes in C9FTLD: compared to non-carriers, mutation carriers showed a significant reduction of glucose metabolism in both thalami, underscoring the key role of the thalamus in C9FTLD. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41398-019-0381-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355852PMC
January 2019
1 Read
4.360 Impact Factor

Efficacy of high-frequency repetitive transcranial magnetic stimulation in schizophrenia patients with treatment-resistant negative symptoms treated with clozapine.

Schizophr Res 2019 Jan 28. Epub 2019 Jan 28.

Department of Psychiatry and Psychotherapy, Klinikum der Universität München, University Hospital, LMU Munich, Germany.

Background: Repetitive transcranial magnetic stimulation (rTMS) is a promising augmentation treatment for schizophrenia, however there are few controlled studies of rTMS augmentation of clozapine.

Methods: Using data from the 'rTMS for the Treatment of Negative Symptoms in Schizophrenia' (RESIS) trial we examined the impact of rTMS on PANSS total, general, positive and negative symptoms among participants on clozapine. rTMS was applied to the left dorsolateral prefrontal cortex (DLPFC) for five treatment sessions/week for 3-weeks as augmentation for patients with a predominant negative syndrome of schizophrenia, as rated on PANSS. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.schres.2019.01.021DOI Listing
January 2019

Same Same but Different: A Clinical Characterization of Men with Hypersexual Disorder in the Sex@Brain Study.

J Clin Med 2019 Jan 30;8(2). Epub 2019 Jan 30.

Department of Psychiatry, Social Psychiatry and Psychotherapy, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.

Problems arising from hypersexual behavior are often seen in clinical settings. We aimed to extend the knowledge about the clinical characteristics of individuals with hypersexual disorder (HD). A group of people who fulfilled the proposed diagnostic criteria for HD (men with HD, = 50) was compared to a group of healthy controls ( = 40). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/jcm8020157DOI Listing
January 2019

Multi-Ancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions.

Authors:
Paul S de Vries Michael R Brown Amy R Bentley Yun J Sung Thomas W Winkler Ioanna Ntalla Karen Schwander Aldi T Kraja Xiuqing Guo Nora Franceschini Ching-Yu Cheng Xueling Sim Dina Vojinovic Jennifer E Huffman Solomon K Musani Changwei Li Mary F Feitosa Melissa A Richard Raymond Noordam Hugues Aschard Traci M Bartz Lawrence F Bielak Xuan Deng Rajkumar Dorajoo Kurt K Lohman Alisa K Manning Tuomo Rankinen Albert V Smith Salman M Tajuddin Evangelos Evangelou Mariaelisa Graff Maris Alver Mathilde Boissel Jin Fang Chai Xu Chen Jasmin Divers Ilaria Gandin Chuan Gao Anuj Goel Yanick Hagemeijer Sarah E Harris Fernando P Hartwig Meian He Andrea R V R Horimoto Fang-Chi Hsu Anne U Jackson Anuradhani Kasturiratne Pirjo Komulainen Brigitte Kühnel Federica Laguzzi Joseph H Lee Jian'an Luan Leo-Pekka Lyytikäinen Nana Matoba Ilja M Nolte Maik Pietzner Muhammad Riaz M Abdullah Said Robert A Scott Tamar Sofer Alena Stancáková Fumihiko Takeuchi Bamidele O Tayo Peter J van der Most Tibor V Varga Yajuan Wang Erin B Ware Wanqing Wen Lisa R Yanek Weihua Zhang Jing Hua Zhao Saima Afaq Najaf Amin Marzyeh Amini Dan E Arking Tin Aung Christie Ballantyne Eric Boerwinkle Ulrich Broeckel Archie Campbell Mickaël Canouil Sabanayagam Charumathi Yii-Der Ida Chen John M Connell Ulf de Faire Lisa de Las Fuentes Renée de Mutsert H Janaka de Silva Jingzhong Ding Anna F Dominiczak Qing Duan Charles B Eaton Ruben N Eppinga Jessica D Faul Virginia Fisher Terrence Forrester Oscar H Franco Yechiel Friedlander Mohsen Ghanbari Franco Giulianini Hans J Grabe Megan L Grove C Charles Gu Tamara B Harris Sami Heikkinen Chew-Kiat Heng Makoto Hirata James E Hixson Barbara V Howard M Arfan Ikram David R Jacobs Craig Johnson Jost Bruno Jonas Candace M Kammerer Tomohiro Katsuya Chiea Chuen Khor Tuomas O Kilpeläinen Woon-Puay Koh Heikki A Koistinen Ivana Kolcic Charles Kooperberg Jose E Krieger Steve B Kritchevsky Michiaki Kubo Johanna Kuusisto Timo A Lakka Carl D Langefeld Claudia Langenberg Lenore J Launer Benjamin Lehne Rozenn N Lemaitre Yize Li Jingjing Liang Jianjun Liu Kiang Liu Marie Loh Tin Louie Reedik Mägi Ani W Manichaikul Colin A McKenzie Thomas Meitinger Andres Metspalu Yuri Milaneschi Lili Milani Karen L Mohlke Thomas H Mosley Kenneth J Mukamal Mike A Nalls Matthias Nauck Christopher P Nelson Nona Sotoodehnia Jeff R O'Connell Nicholette D Palmer Raha Pazoki Nancy L Pedersen Annette Peters Patricia A Peyser Ozren Polasek Neil Poulter Leslie J Raffel Olli T Raitakari Alex P Reiner Treva K Rice Stephen S Rich Antonietta Robino Jennifer G Robinson Lynda M Rose Igor Rudan Carsten O Schmidt Pamela J Schreiner William R Scott Peter Sever Yuan Shi Stephen Sidney Mario Sims Blair H Smith Jennifer A Smith Harold Snieder John M Starr Konstantin Strauch Nicholas Tan Kent D Taylor Yik Ying Teo Yih Chung Tham André G Uitterlinden Diana van Heemst Dragana Vuckovic Melanie Waldenberger Lihua Wang Yujie Wang Zhe Wang Wen Bin Wei Christine Williams Gregory Wilson Mary K Wojczynski Jie Yao Bing Yu Caizheng Yu Jian-Min Yuan Wei Zhao Alan B Zonderman Diane M Becker Michael Boehnke Donald W Bowden John C Chambers Ian J Deary Tõnu Esko Martin Farrall Paul W Franks Barry I Freedman Philippe Froguel Paolo Gasparini Christian Gieger Bernardo L Horta Yoichiro Kamatani Norihiro Kato Jaspal S Kooner Markku Laakso Karin Leander Terho Lehtimäki Patrik K E Magnusson Brenda Penninx Alexandre C Pereira Rainer Rauramaa Nilesh J Samani James Scott Xiao-Ou Shu Pim van der Harst Lynne E Wagenknecht Ya Xing Wang Nicholas J Wareham Hugh Watkins David R Weir Ananda R Wickremasinghe Wei Zheng Paul Elliott Kari E North Claude Bouchard Michele K Evans Vilmundur Gudnason Ching-Ti Liu Yongmei Liu Bruce M Psaty Paul M Ridker Rob M van Dam Sharon L R Kardia Xiaofeng Zhu Charles N Rotimi Dennis O Mook-Kanamori Myriam Fornage Tanika N Kelly Ervin R Fox Caroline Hayward Cornelia M van Duijn E Shyong Tai Tien Yin Wong Jingmin Liu Jerome I Rotter W James Gauderman Michael A Province Patricia B Munroe Kenneth Rice Daniel I Chasman L Adrienne Cupples Dabeeru C Rao Alanna C Morrison

Am J Epidemiol 2019 Jan 29. Epub 2019 Jan 29.

Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas.

An individual's lipid profile is influenced by genetic variants and alcohol consumption, but the contribution of interactions between these exposures has not been studied. We therefore incorporated gene-alcohol interactions into a multi-ancestry genome-wide association study of levels of high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and triglycerides. We included 45 studies in Stage 1 (genome-wide discovery) and 66 studies in Stage 2 (focused follow-up), for a total of 394,584 individuals from five ancestry groups. Read More

View Article

Download full-text PDF

Source
https://academic.oup.com/aje/advance-article/doi/10.1093/aje
Publisher Site
http://dx.doi.org/10.1093/aje/kwz005DOI Listing
January 2019
7 Reads
5.230 Impact Factor

Effective connectivity in the default mode network is distinctively disrupted in Alzheimer's disease-A simultaneous resting-state FDG-PET/fMRI study.

Hum Brain Mapp 2019 Jan 30. Epub 2019 Jan 30.

TUM-Neuroimaging Center (TUM-NIC), Klinikum Rechts der Isar, München, Germany.

A prominent finding of postmortem and molecular imaging studies on Alzheimer's disease (AD) is the accumulation of neuropathological proteins in brain regions of the default mode network (DMN). Molecular models suggest that the progression of disease proteins depends on the directionality of signaling pathways. At network level, effective connectivity (EC) reflects directionality of signaling pathways. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/hbm.24517DOI Listing
January 2019
2 Reads

Factors associated with satisfaction of inpatient psychiatric care: a cross country comparison.

Psychol Med 2019 Jan 30:1-9. Epub 2019 Jan 30.

Unit for Social and Community Psychiatry (World Health Organisation Collaborating Centre for Mental Health Services Development),Queen Mary University of London,London,UK.

Background: Patient satisfaction is a key indicator of inpatient care quality and is associated with clinical outcomes following admission. Different patient characteristics have been inconsistently linked with satisfaction. This study aims to overcome previous limitations by assessing which patient characteristics are associated with satisfaction within a large study of psychiatric inpatients conducted across five European countries. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1017/S0033291719000011DOI Listing
January 2019

Do patients consider computer-adaptive measures more appropriate than static questionnaires?

J Patient Rep Outcomes 2019 Jan 29;3(1). Epub 2019 Jan 29.

Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatry II, Medical University of Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria.

Objective: Computer-adaptive tests (CAT) use individualised sets of questions to assess patient-reported health states, whereas static (conventional) questionnaires present the same questions to all patients. CAT has been shown to increase measurement precision and reduce assessment length. In our study, we investigated if patients perceive CAT questions as more appropriate than static questionnaires, a claim that is frequently associated with CAT measures. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s41687-019-0096-3DOI Listing
January 2019

Psychotic Features in Patients With Major Depressive Disorder: A Report From the European Group for the Study of Resistant Depression.

J Clin Psychiatry 2019 Jan 15;80(1). Epub 2019 Jan 15.

Department of Psychiatry and Psychotherapy, Medical University of Vienna, Währinger Gürtel 18-20, A-1090 Vienna, Austria.

Objective: To elucidate the impact of the presence of psychotic features in patients diagnosed with major depressive disorder (MDD) on sociodemographic, psychosocial, clinical, and response characteristics.

Methods: A total of 1,410 DSM-IV-TR MDD patients were included in the present European multicenter study, which was conducted between 2011 and 2016. Analyses of covariance, χ² tests, and binary logistic regression analyses were performed to explore differences in sociodemographic and clinical variables between MDD patients with and without psychotic symptoms. Read More

View Article

Download full-text PDF

Source
https://www.psychiatrist.com/JCP/article/Pages/2019/v80/17m1
Publisher Site
http://dx.doi.org/10.4088/JCP.17m12090DOI Listing
January 2019
5 Reads

Generalizing age effects on brain structure and cognition: A two-study comparison approach.

Hum Brain Mapp 2019 Jan 22. Epub 2019 Jan 22.

University Research Priority Program Dynamics of Healthy Aging, University of Zurich, Zurich, Switzerland.

Normal aging is accompanied by an interindividually variable decline in cognitive abilities and brain structure. This variability, in combination with methodical differences and differences in sample characteristics across studies, pose a major challenge for generalizability of results from different studies. Therefore, the current study aimed at cross-validating age-related differences in cognitive abilities and brain structure (measured using cortical thickness [CT]) in two large independent samples, each consisting of 228 healthy older adults aged between 65 and 85 years: the Longitudinal Healthy Aging Brain (LHAB) database (University of Zurich, Switzerland) and the 1000BRAINS (Research Centre Jülich, Germany). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/hbm.24524DOI Listing
January 2019

Intermittent theta burst stimulation over right somatosensory larynx cortex enhances vocal pitch-regulation in nonsingers.

Hum Brain Mapp 2019 Jan 21. Epub 2019 Jan 21.

Institute of Medical Psychology and Behavioral Neurobiology, Eberhard Karls University Tübingen, Tübingen, Germany.

While the significance of auditory cortical regions for the development and maintenance of speech motor coordination is well established, the contribution of somatosensory brain areas to learned vocalizations such as singing is less well understood. To address these mechanisms, we applied intermittent theta burst stimulation (iTBS), a facilitatory repetitive transcranial magnetic stimulation (rTMS) protocol, over right somatosensory larynx cortex (S1) and a nonvocal dorsal S1 control area in participants without singing experience. A pitch-matching singing task was performed before and after iTBS to assess corresponding effects on vocal pitch regulation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/hbm.24515DOI Listing
January 2019
1 Read

Symptom manifestation and treatment effectiveness, -obstacles and -facilitators in Turkish and Moroccan groups with depression in European countries: A systematic review.

J Affect Disord 2019 Mar 21;247:134-155. Epub 2018 Dec 21.

Department of Medical and Clinical Psychology, Tilburg University, Tilburg, the Netherlands. Electronic address:

Background: This study examined the state of the art relevant for clinical practice on symptom manifestation of depression or depression-related idioms of distress, the treatment effectiveness and obstacles and facilitators for therapeutic success in Turkish and Moroccan immigrant populations with depression in Europe.

Methods: We conducted a systematic search in PsycINFO, MEDLINE, Science Direct, Web of Knowledge, and Cochrane databases (1970- 31 July 2017). Peer-reviewed studies, with adult populations, and an instrument assessing depressive symptoms met inclusion criteria and were evaluated following quality guidelines. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jad.2018.12.060DOI Listing
March 2019
2 Reads

Allele Frequencies in Depressed Patients of European Descent in Russia.

Front Genet 2018 4;9:686. Epub 2019 Jan 4.

Institute of Physiology and Basic Medicine, Novosibirsk, Russia.

Depressive disorder (DD) is a widespread mental disorder. Although DD is to some extent inherited, the genes contributing to the risk of this disorder and its genetic mechanisms remain poorly understood. A recent large-scale genome-wide association Chinese study revealed a strong association between the gene variants and DD. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fgene.2018.00686DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328450PMC
January 2019
1 Read

Stratification and prediction of remission in first-episode psychosis patients: the OPTiMiSE cohort study.

Transl Psychiatry 2019 Jan 17;9(1):20. Epub 2019 Jan 17.

Université Côte d'Azur, Centre National de la Recherche Scientifique, Institut de Pharmacologie Moléculaire et Cellulaire, Valbonne, France.

Early response to first-line antipsychotic treatments is strongly associated with positive long-term symptomatic and functional outcome in psychosis. Unfortunately, attempts to identify reliable predictors of treatment response in first-episode psychosis (FEP) patients have not yet been successful. One reason for this could be that FEP patients are highly heterogeneous in terms of symptom expression and underlying disease biological mechanisms, thereby impeding the identification of one-size-fits-all predictors of treatment response. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41398-018-0366-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336802PMC
January 2019
1 Read

Prevalence of abnormal Alzheimer's disease biomarkers in patients with subjective cognitive decline: cross-sectional comparison of three European memory clinic samples.

Alzheimers Res Ther 2019 Jan 17;11(1). Epub 2019 Jan 17.

German Center for Neurodegenerative Diseases, Sigmund-Freud-Straße 27, 53127, Bonn, Germany.

Introduction: Subjective cognitive decline (SCD) in cognitively unimpaired older individuals has been recognized as an early clinical at-risk state for Alzheimer's disease (AD) dementia and as a target population for future dementia prevention trials. Currently, however, SCD is heterogeneously defined across studies, potentially leading to variations in the prevalence of AD pathology. Here, we compared the prevalence and identified common determinants of abnormal AD biomarkers in SCD across three European memory clinics participating in the European initiative on harmonization of SCD in preclinical AD (Euro-SCD). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13195-018-0463-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337830PMC
January 2019
6 Reads

Neurological Emergencies in Refugees.

Front Neurol 2018 11;9:1088. Epub 2018 Dec 11.

Department of Neurology, Charité-Universitätsmedizin Berlin, Berlin, Germany.

Health care personnel in Europe is increasingly involved in care of displaced persons from non-European countries; we investigated the spectrum of neurological disorders and medical management in refugees presenting to the emergency room (ER) of a German university hospital. We retrospectively studied ER-patients with refugee status (R-patients) during the peak of the European refugee crisis between July 2015 and February 2016 ( = 100). Complaints on admission, medical management and diagnoses at discharge were compared to matched groups of German residents with migrational background (M-patients; = 96) and to native Germans (N-patients; = 95). Read More

View Article

Download full-text PDF

Source
https://www.frontiersin.org/article/10.3389/fneur.2018.01088
Publisher Site
http://dx.doi.org/10.3389/fneur.2018.01088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298418PMC
December 2018
6 Reads

Trauma and trauma care in Europe.

Eur J Psychotraumatol 2018 20;9(1):1556553. Epub 2018 Dec 20.

Research Department, Combat Stress, Leatherhead, UK & King's Centre for Military Health Research, Department of Psychological Medicine, King's College London, London, UK.

The European countries have a long history of exposure to large-scale trauma. In the early 1990s the increasing awareness of the consequences of trauma within the mental health community led to the foundation of local societies for psychotraumatology across Europe and the European Society of Traumatic Stress Studies (ESTSS), which celebrated its 25th anniversary in 2018. The focus of this article is to describe the current state of care for survivors of trauma in the 15 European countries where ESTSS member societies have been established. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/20008198.2018.1
Publisher Site
http://dx.doi.org/10.1080/20008198.2018.1556553DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319458PMC
December 2018
3 Reads

Influence of antidepressant therapy on sick leave in primary care: ADAS, a comparative observational study.

Heliyon 2019 Jan 4;5(1):e01101. Epub 2019 Jan 4.

Department of Primary Health Care, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden.

Background: Compared to other European countries, Sweden's yearly sick leave expenditures are moderate. Common mental disorders (CMD) are important causes of sick leave, affecting 10-15% of the adult population. A Swedish register based study indicates that antidepressant therapy for patients on long-term sick leave for CMD leads to longer sick leave and higher frequency of non-time-limited sickness compensation as compared to psychotherapy, work oriented rehabilitation, and other therapies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.heliyon.2018.e01101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321886PMC
January 2019
1 Read

Obesity, depression and hip pain.

Musculoskeletal Care 2019 Jan 8. Epub 2019 Jan 8.

Clinic for Orthopedics and Trauma Surgery, Center for Orthopedics, Trauma Surgery and Spinal Cord Injury, Heidelberg University Hospital, Heidelberg, Germany.

Introduction: Up to 64% of the general population reports experiencing chronic pain, with the hip being one of the most frequent sites. An association has been shown between chronic back pain, obesity and depression. To date, a similar association has not been investigated with chronic hip pain. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/msc.1380DOI Listing
January 2019
1 Read

Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci.

Authors:
A Mesut Erzurumluoglu Mengzhen Liu Victoria E Jackson Daniel R Barnes Gargi Datta Carl A Melbourne Robin Young Chiara Batini Praveen Surendran Tao Jiang Sheikh Daud Adnan Saima Afaq Arpana Agrawal Elisabeth Altmaier Antonis C Antoniou Folkert W Asselbergs Clemens Baumbach Laura Bierut Sarah Bertelsen Michael Boehnke Michiel L Bots David M Brazel John C Chambers Jenny Chang-Claude Chu Chen Janie Corley Yi-Ling Chou Sean P David Rudolf A de Boer Christiaan A de Leeuw Joe G Dennis Anna F Dominiczak Alison M Dunning Douglas F Easton Charles Eaton Paul Elliott Evangelos Evangelou Jessica D Faul Tatiana Foroud Alison Goate Jian Gong Hans J Grabe Jeff Haessler Christopher Haiman Göran Hallmans Anke R Hammerschlag Sarah E Harris Andrew Hattersley Andrew Heath Chris Hsu William G Iacono Stavroula Kanoni Manav Kapoor Jaakko Kaprio Sharon L Kardia Fredrik Karpe Jukka Kontto Jaspal S Kooner Charles Kooperberg Kari Kuulasmaa Markku Laakso Dongbing Lai Claudia Langenberg Nhung Le Guillaume Lettre Anu Loukola Jian'an Luan Pamela A F Madden Massimo Mangino Riccardo E Marioni Eirini Marouli Jonathan Marten Nicholas G Martin Matt McGue Kyriaki Michailidou Evelin Mihailov Alireza Moayyeri Marie Moitry Martina Müller-Nurasyid Aliya Naheed Matthias Nauck Matthew J Neville Sune Fallgaard Nielsen Kari North Markus Perola Paul D P Pharoah Giorgio Pistis Tinca J Polderman Danielle Posthuma Neil Poulter Beenish Qaiser Asif Rasheed Alex Reiner Frida Renström John Rice Rebecca Rohde Olov Rolandsson Nilesh J Samani Maria Samuel David Schlessinger Steven H Scholte Robert A Scott Peter Sever Yaming Shao Nick Shrine Jennifer A Smith John M Starr Kathleen Stirrups Danielle Stram Heather M Stringham Ioanna Tachmazidou Jean-Claude Tardif Deborah J Thompson Hilary A Tindle Vinicius Tragante Stella Trompet Valerie Turcot Jessica Tyrrell Ilonca Vaartjes Andries R van der Leij Peter van der Meer Tibor V Varga Niek Verweij Henry Völzke Nicholas J Wareham Helen R Warren David R Weir Stefan Weiss Leah Wetherill Hanieh Yaghootkar Ersin Yavas Yu Jiang Fang Chen Xiaowei Zhan Weihua Zhang Wei Zhao Wei Zhao Kaixin Zhou Philippe Amouyel Stefan Blankenberg Mark J Caulfield Rajiv Chowdhury Francesco Cucca Ian J Deary Panos Deloukas Emanuele Di Angelantonio Marco Ferrario Jean Ferrières Paul W Franks Tim M Frayling Philippe Frossard Ian P Hall Caroline Hayward Jan-Håkan Jansson J Wouter Jukema Frank Kee Satu Männistö Andres Metspalu Patricia B Munroe Børge Grønne Nordestgaard Colin N A Palmer Veikko Salomaa Naveed Sattar Timothy Spector David Peter Strachan Pim van der Harst Eleftheria Zeggini Danish Saleheen Adam S Butterworth Louise V Wain Goncalo R Abecasis John Danesh Martin D Tobin Scott Vrieze Dajiang J Liu Joanna M M Howson

Mol Psychiatry 2019 Jan 7. Epub 2019 Jan 7.

MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK.

Smoking is a major heritable and modifiable risk factor for many diseases, including cancer, common respiratory disorders and cardiovascular diseases. Fourteen genetic loci have previously been associated with smoking behaviour-related traits. We tested up to 235,116 single nucleotide variants (SNVs) on the exome-array for association with smoking initiation, cigarettes per day, pack-years, and smoking cessation in a fixed effects meta-analysis of up to 61 studies (up to 346,813 participants). Read More

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41380-018-0313-0
Publisher Site
http://dx.doi.org/10.1038/s41380-018-0313-0DOI Listing
January 2019
8 Reads
14.496 Impact Factor

The influence of religious activity and polygenic schizophrenia risk on religious delusions in schizophrenia.

Schizophr Res 2019 Jan 3. Epub 2019 Jan 3.

Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich 80336, Germany; Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen 37075, Germany.

Background: Religious delusions are a common symptom in patients experiencing psychosis, with varying prevalence rates of religious delusions across cultures and societies. To enhance our knowledge of this distinct psychotic feature, we investigated the mutually-adjusted association of genetic and environmental factors with occurrence of religious delusions.

Methods: We studied 262 adult German patients with schizophrenia or schizoaffective disorder. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.schres.2018.12.025DOI Listing
January 2019
3 Reads

Erlangen Score as a tool to predict progression from mild cognitive impairment to dementia in Alzheimer's disease.

Alzheimers Res Ther 2019 Jan 5;11(1). Epub 2019 Jan 5.

Department of Neurodegeneration Diagnostics, Medical University of Białystok, Białystok, Poland.

Background: The previously described and validated Erlangen Score (ES) algorithm enables interpretation of the cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD), ordering them on an ordinal scale: from neurochemically normal (ES = 0) through improbable AD (ES = 1), possible AD (ES = 2 or 3), to probable AD (ES = 4). Here we assess the accuracy of the ES in predicting hazards of progression from the mild cognitive impairment (MCI) stage of AD to the dementia stage of the disease (Alzheimer's disease dementia (ADD)) in a novel, single-center cohort.

Methods: Baseline CSF biomarkers (amyloid beta (Aβ) 1-42, Aβ42/40, Tau, and pTau181), interpreted according to the ES, were used to estimate time to progression from the MCI stage of AD to ADD, conditional on age, gender, APOE ε4 genotype, and Mini Mental State Examination score in 144 MCI subjects, using the Extended Cox Model; the subjects were followed-up until they developed dementia or until they had been cognitively stable for at least 2 years. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13195-018-0456-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320577PMC
January 2019
2 Reads

Psychotherapy in Europe.

Authors:
Sarah Marks

Hist Human Sci 2018 Oct 12;31(4):3-12. Epub 2018 Dec 12.

Birkbeck, University of London, UK.

Psychotherapy was an invention of European modernity, but as the 20th century unfolded, and we trace how it crossed national and continental borders, its goals and the particular techniques by which it operated become harder to pin down. This introduction briefly draws together the historical literature on psychotherapy in Europe, asking comparative questions about the role of location and culture, and networks of transmission and transformation. It introduces the six articles in this special issue on Greece, Hungary, Yugoslavia, Russia, Britain and Sweden as well as its parallel special issue of on 'Psychotherapy in the Americas'. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0952695118808411DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297894PMC
October 2018

Ten-Item Internet Gaming Disorder Test (IGDT-10): Measurement invariance and cross-cultural validation across seven language-based samples.

Psychol Addict Behav 2019 Feb 27;33(1):91-103. Epub 2018 Dec 27.

Institute of Psychology.

The Ten-Item Internet Gaming Disorder Test (IGDT-10) is a short screening instrument developed to assess Internet gaming disorder (IGD) as proposed in the , fifth edition (), adopting a concise, clear, and consistent item-wording. According to initial studies conducted in 2014, the instrument showed promising psychometric characteristics. The present study tested the psychometric properties, including language and gender invariance, in a large international sample of online gamers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1037/adb0000433DOI Listing
February 2019
1 Read

An opposing function of paralogs in balancing developmental synapse maturation.

PLoS Biol 2018 Dec 26;16(12):e2006838. Epub 2018 Dec 26.

European Neuroscience Institute Göttingen, University Medical Center, Göttingen, Germany.

The disc-large (DLG)-membrane-associated guanylate kinase (MAGUK) family of proteins forms a central signaling hub of the glutamate receptor complex. Among this family, some proteins regulate developmental maturation of glutamatergic synapses, a process vulnerable to aberrations, which may lead to neurodevelopmental disorders. As is typical for paralogs, the DLG-MAGUK proteins postsynaptic density (PSD)-95 and PSD-93 share similar functional domains and were previously thought to regulate glutamatergic synapses similarly. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pbio.2006838DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324823PMC
December 2018
1 Read

The IASP classification of chronic pain for ICD-11: chronic neuropathic pain.

Pain 2019 Jan;160(1):53-59

Department of Neurophysiology, CBTM, Medical Faculty Mannheim of Heidelberg University, Mannheim, Germany.

The upcoming 11th revision of the International Statistical Classification of Diseases and Related Health Problems (ICD) of the World Health Organization (WHO) offers a unique opportunity to improve the representation of painful disorders. For this purpose, the International Association for the Study of Pain (IASP) has convened an interdisciplinary task force of pain specialists. Here, we present the case for a reclassification of nervous system lesions or diseases associated with persistent or recurrent pain for ≥3 months. Read More

View Article

Download full-text PDF

Source
http://Insights.ovid.com/crossref?an=00006396-201901000-0000
Publisher Site
http://dx.doi.org/10.1097/j.pain.0000000000001365DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310153PMC
January 2019
12 Reads
5.213 Impact Factor

The IASP classification of chronic pain for ICD-11: chronic cancer-related pain.

Pain 2019 Jan;160(1):38-44

Department of Neurophysiology, CBTM, Medical Faculty Mannheim of Heidelberg University, Mannheim, Germany.

Worldwide, the prevalence of cancer is rising and so too is the number of patients who survive their cancer for many years thanks to the therapeutic successes of modern oncology. One of the most frequent and disabling symptoms of cancer is pain. In addition to the pain caused by the cancer, cancer treatment may also lead to chronic pain. Read More

View Article

Download full-text PDF

Source
http://Insights.ovid.com/crossref?an=00006396-201901000-0000
Publisher Site
http://dx.doi.org/10.1097/j.pain.0000000000001363DOI Listing
January 2019
1 Read

Chronic pain as a symptom or a disease: the IASP Classification of Chronic Pain for the International Classification of Diseases (ICD-11).

Pain 2019 Jan;160(1):19-27

The Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan.

Chronic pain is a major source of suffering. It interferes with daily functioning and often is accompanied by distress. Yet, in the International Classification of Diseases, chronic pain diagnoses are not represented systematically. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/j.pain.0000000000001384DOI Listing
January 2019
3 Reads
5.213 Impact Factor

Associations of adverse childhood experiences and bullying on physical pain in the general population of Germany.

J Pain Res 2018 6;11:3099-3108. Epub 2018 Dec 6.

Institute of Clinical and Experimental Trauma-Immunology, University of Ulm, Ulm, Germany.

Background: Chronic pain is a frequent burden in the general population. Child maltreatment and bullying are risk factors for the development of chronic pain. Aim of this cross-sectional study was to investigate the association of child maltreatment and bullying and pain experiences in a representative sample of the general population. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/JPR.S169135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287510PMC
December 2018

Predictors of personal continuity of care of patients with severe mental illness: A comparison across five European countries.

Eur Psychiatry 2019 Feb 22;56:69-74. Epub 2018 Dec 22.

Institute of Health and Society IRSS, Université catholique de Louvain, Brussels, Belgium.

Background: In Europe, at discharge from a psychiatric hospital, patients with severe mental illness may be exposed to one of two main care approaches: personal continuity, where one clinician is responsible for in- and outpatient care, and specialisation, where various clinicians are. Such exposure is decided through patient-clinician agreement or at the organisational level, depending on the country's health system. Since personal continuity would be more suitable for patients with complex psychosocial needs, the aim of this study was to identify predictors of patients' exposure to care approaches in different European countries. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S09249338183020
Publisher Site
http://dx.doi.org/10.1016/j.eurpsy.2018.12.003DOI Listing
February 2019
9 Reads

Health Care for Persistent Somatic Symptoms Across Europe: A Qualitative Evaluation of the EURONET-SOMA Expert Discussion.

Front Psychiatry 2018 7;9:646. Epub 2018 Dec 7.

Department of Psychosomatic Medicine and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Persistent somatic symptoms (PSS), referred to as somatoform disorders and lately somatic symptom disorders, are frequent but often remain under-recognized and under-treated. Although European guidelines overlap, presumably, there is large diversity in their practical use and in the actual health care situation. The aim of this qualitative evaluation was to compare health care for PSS across 9 European countries, to illustrate commonalities and differences, and to discuss challenges for a pan-European research agenda. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fpsyt.2018.00646DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292948PMC
December 2018
1 Read

General population normative data for the EORTC QLQ-C30 health-related quality of life questionnaire based on 15,386 persons across 13 European countries, Canada and the Unites States.

Eur J Cancer 2019 Jan 19;107:153-163. Epub 2018 Dec 19.

Department of Psychosomatic Medicine, Center for Internal Medicine and Dermatology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany; Quantitative Health Sciences, Outcomes Measurement Science, University of Massachusetts Medical School, Worcester, MA, USA.

Objective: The European Organisation for Research and Treatment of Cancer (EORTC) QLQ-C30 health-related quality of life questionnaire is one of the most widely used cancer-specific health-related quality of life questionnaires worldwide. General population norm data can facilitate the interpretation of QLQ-C30 data obtained from cancer patients. This study aimed at systematically collecting norm data from the general population to develop European QLQ-C30 norm scores and to generate comparable norm data for individual countries in Europe and North America. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S09598049183152
Publisher Site
http://dx.doi.org/10.1016/j.ejca.2018.11.024DOI Listing
January 2019
71 Reads

Establishing the European Norm for the health-related quality of life domains of the computer-adaptive test EORTC CAT Core.

Eur J Cancer 2019 Jan 18;107:133-141. Epub 2018 Dec 18.

Department of Psychosomatic Medicine, Center for Internal Medicine and Dermatology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Berlin, Germany; Population Health Strategic Research Centre, School of Health and Social Development, Deakin University, Burwood, VIC, Australia. Electronic address:

Objective: The computer-adaptive test (CAT) of the European Organisation for Research and Treatment of Cancer (EORTC), the EORTC CAT Core, assesses the same 15 domains as the EORTC QLQ-C30 health-related quality of life questionnaire but with increased precision, efficiency, measurement range and flexibility. CAT parameters for estimating scores have been established based on clinical data from cancer patients. This study aimed at establishing the European Norm for each CAT domain based on general population data. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejca.2018.11.023DOI Listing
January 2019
1 Read

Neurophysiological Effects of Dorsal Root Ganglion Stimulation (DRGS) in Pain Processing at the Cortical Level.

Neuromodulation 2019 Jan 18;22(1):36-43. Epub 2018 Dec 18.

Department of Neurosurgery, University of Tuebingen, Tuebingen, Germany.

Objectives: Dorsal root ganglion stimulation (DRGS) has been used successfully against localized neuropathic pain. Nevertheless, the effects of DRGS on pain processing, particularly at the cortical level, remain largely unknown. In this study, we investigated whether positive responses to DRGS treatment would alter patients' laser-evoked potentials (LEP). Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/ner.12900
Publisher Site
http://dx.doi.org/10.1111/ner.12900DOI Listing
January 2019
7 Reads

The same or different psychiatrists for in- and out-patient treatment? A multi-country natural experiment.

Epidemiol Psychiatr Sci 2018 Dec 18:1-9. Epub 2018 Dec 18.

Unit for Social and Community Psychiatry (World Health Organisation Collaborating Centre for Mental Health Services Development),Queen Mary University of London,London,UK.

AimsA core question in the debate about how to organise mental healthcare is whether in- and out-patient treatment should be provided by the same (personal continuity) or different psychiatrists (specialisation). The controversial debate drives costly organisational changes in several European countries, which have gone in opposing directions. The existing evidence is based on small and low-quality studies which tend to favour whatever the new experimental organisation is. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1017/S2045796018000732DOI Listing
December 2018
1 Read

Factors that influence access to mental health services in South-Eastern Europe.

Int J Ment Health Syst 2018 7;12:75. Epub 2018 Dec 7.

7OHSU-PSU School of Public Health, Portland, OR USA.

Introduction: Access to mental health (MH) services is unequal worldwide and changes are required in this respect.

Objectives: Our aim was to identify the delay to the first psychiatry consult and to understand patients' characteristics and perspectives on the factors that may influence the delay, among a sample of participants from three Southeastern European Countries.

Materials And Methods: The WHO Pathway Encounter Form questionnaire was applied in 400 patients "new cases" and a questionnaire on the factors influencing the access was administered to the same patients, as well as to their caretakers and MH providers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13033-018-0255-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284270PMC
December 2018

Peer counseling in depression care: A pilot study in a psychiatric inpatient setting.

Psychiatry Res 2018 12 25;270:698-704. Epub 2018 Oct 25.

Department of Psychiatry and Psychotherapy, University Leipzig, Leipzig, Germany.

To evaluate in a pilot study whether peer counseling is feasible and accepted for inpatients with depression. A one-to-one peer counseling intervention was implemented in an inpatient psychiatric department. Patients were invited to ask questions concerning their illness. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01651781183117
Publisher Site
http://dx.doi.org/10.1016/j.psychres.2018.10.058DOI Listing
December 2018
10 Reads

Synaptotagmin-3 drives AMPA receptor endocytosis, depression of synapse strength, and forgetting.

Science 2019 01 13;363(6422). Epub 2018 Dec 13.

Trans-synaptic Signaling Group, European Neuroscience Institute, 37077 Goettingen, Germany.

Forgetting is important. Without it, the relative importance of acquired memories in a changing environment is lost. We discovered that synaptotagmin-3 (Syt3) localizes to postsynaptic endocytic zones and removes AMPA receptors from synaptic plasma membranes in response to stimulation. Read More

View Article

Download full-text PDF

Source
http://www.sciencemag.org/lookup/doi/10.1126/science.aav1483
Publisher Site
http://dx.doi.org/10.1126/science.aav1483DOI Listing
January 2019
22 Reads

Peer victimization and its impact on adolescent brain development and psychopathology.

Mol Psychiatry 2018 Dec 12. Epub 2018 Dec 12.

Medical Research Council - Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.

Chronic peer victimization has long-term impacts on mental health; however, the biological mediators of this adverse relationship are unknown. We sought to determine whether adolescent brain development is involved in mediating the effect of peer victimization on psychopathology. We included participants (n = 682) from the longitudinal IMAGEN study with both peer victimization and neuroimaging data. Read More

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41380-018-0297-9
Publisher Site
http://dx.doi.org/10.1038/s41380-018-0297-9DOI Listing
December 2018
11 Reads

Allele-Specific Methylation of SPDEF: A Novel Moderator of Psychosocial Stress and Substance Abuse.

Am J Psychiatry 2019 Feb 11;176(2):146-155. Epub 2018 Dec 11.

The Centre for Population Neuroscience and Stratified Medicine and SGDP Centre, Institute of Psychiatry, King's College London (Tay, Macare, Ruggeri, Jia, Chu, Biondo, Ing, Quinlan, Desrivières, Barker, Schumann); the Department of Biochemistry and Molecular Biology, MOE Key Laboratory of Metabolism and Molecular Medicine, School of Basic Medical Sciences, Fudan University, Shanghai, China (Liu); the Institute of Science and Technology of Brain-Inspired Intelligence, Fudan University, Shanghai, China (Jia); the Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence, Fudan University, Ministry of Education, Shanghai, China (Jia); the School of Life Sciences and Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China (Luo); Uppsala University, Uppsala, Sweden (Sarkysian, Bakalkin); the Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany (Banaschewski, Hohmann); the Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology, and Neuroscience, King's College London (Barker); the Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin (Bokde, Nees); University Medical Centre Hamburg-Eppendorf, Hamburg, Germany (Bromberg, Büchel); the Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany (Flor, Nees); the Department of Psychology, School of Social Sciences, University of Mannheim, Mannheim, Germany (Flor); the Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany (Nees); the German Research Foundation, Bonn, Germany (Nees); NeuroSpin, Université Paris-Saclay, Gif-sur-Yvette, France (Frouin, Orfanos); the Departments of Psychiatry and Psychology, University of Vermont, Burlington (Garavan); Sir Peter Mansfield Imaging Centre School of Physics and Astronomy, University of Nottingham, Nottingham, United Kingdom (Gowland); the Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité, Universitätsmedizin Berlin, Berlin (Heinz, Walter); Physikalisch-Technische Bundesanstalt, Braunschweig and Berlin, Berlin (Itterman); the Institut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 "Neuroimaging & Psychiatry," DIGITEO Labs, University Paris Sud-Paris Saclay, University Paris Descartes, Gif sur Yvette, France (Martinot); the Maison de Solenn, Cochin Hospital, Paris, France (Martinot); the Institut National de la Santé et de la Recherche Médicale, University Paris Sud-University Paris Saclay, DIGITEO Labs, Gif sur Yvette, France (Artiges); the Department of Psychiatry, Orsay Hospital, Orsay, France (Artiges); the Bloorview Research Institute, Holland Bloorview Kids Rehabilitation, Hospital and Departments of Psychology and Psychiatry, Bloorview Research Institute, University of Toronto, Toronto ( Paus); the Department of Child and Adolescent Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany (Poustka); the Clinic for Child and Adolescent Psychiatry, Medical University of Vienna, Vienna (Poustka); the Department of Psychiatry and the Neuroimaging Center, Technische Universität Dresden, Dresden, Germany (Fröhner, Smolka); the School of Psychology and the Global Brain Health Institute, Trinity College Dublin, Dublin (Whelan); the Department of Psychiatry, Social Psychiatry, and Psychotherapy, Hannover Medical School, Hannover, Germany (Frieling, Bleich); the Department of Medical Sciences, Molecular Medicine and Science for Life laboratory, Uppsala University, Uppsala, Sweden (Syvänen); and the Department of Clinical Neuroscience, Center for Molecular Medicine, Karolinska Institutet, Stockholm (Rüegg, Ekström).

Objective:: Psychosocial stress is a key risk factor for substance abuse among adolescents. Recently, epigenetic processes such as DNA methylation have emerged as potential mechanisms that could mediate this relationship. The authors conducted a genome-wide methylation analysis to investigate whether differentially methylated regions are associated with psychosocial stress in an adolescent population. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1176/appi.ajp.2018.17121360DOI Listing
February 2019
2 Reads
12.295 Impact Factor

Efficient region-based test strategy uncovers genetic risk factors for functional outcome in bipolar disorder.

Eur Neuropsychopharmacol 2019 Jan 29;29(1):156-170. Epub 2018 Nov 29.

Department of Genetic Epidemiology, University Medical Center Göttingen, Georg-August-University, Göttingen 37099, Germany. Electronic address:

Genome-wide association studies of case-control status have advanced the understanding of the genetic basis of psychiatric disorders. Further progress may be gained by increasing sample size but also by new analysis strategies that advance the exploitation of existing data, especially for clinically important quantitative phenotypes. The functionally-informed efficient region-based test strategy (FIERS) introduced herein uses prior knowledge on biological function and dependence of genotypes within a powerful statistical framework with improved sensitivity and specificity for detecting consistent genetic effects across studies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.euroneuro.2018.10.005DOI Listing
January 2019
3 Reads