297,278 results match your criteria European Journal of Psychology of Education [Journal]


Balancing Protection and Free Movement of Personal Data: The New European Union General Data Protection Regulation.

Ann Intern Med 2019 Feb 19. Epub 2019 Feb 19.

Clinical Effectiveness Research Group, Oslo University Hospital, Oslo, Norway (N.H.).

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http://dx.doi.org/10.7326/M18-2782DOI Listing
February 2019

Discussion: Illegal kills of protected wolves call for public reasoning.

Sci Total Environ 2019 Feb 12;665:617-619. Epub 2019 Feb 12.

Aarhus University, Department of Bioscience, Grenåvej 14, DK-8410 Rønde, Denmark. Electronic address:

Illegal wolf kills happens around in Europe despite the European wolf is protected under the EU Habitats Directive. The reason for this is conflicts with farmers and local hunters and in some instances also direct fear. In April 2018, a wolf was killed in Denmark after 1st recolonization since the 18th century. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.01.432DOI Listing
February 2019

Quantification of second generation direct-acting antivirals daclatasvir, elbasvir, grazoprevir, ledipasvir, simeprevir, sofosbuvir and velpatasvir in human plasma by UPLC-MS/MS.

J Chromatogr B Analyt Technol Biomed Life Sci 2019 Jan 28;1110-1111:15-24. Epub 2019 Jan 28.

Dept of Pharmacy, Radboud Institute for Health Sciences (RIHS), Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525 GA Nijmegen, the Netherlands.

Direct-acting antivirals (DAA) have markedly improved the treatment of hepatitis C, with a series of DAA combinations available for treatment. A sensitive method by ultra-high performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) was developed for the simultaneous quantification of seven commonly used DAAs, daclatasvir (DAC), elbasvir (ELB), grazoprevir (GZR), ledipasvir (LDV), simeprevir (SIM), sofosbuvir (SOF), velpatasvir (VEL) and the primary analyte of interest of SOF (GS-331007) in EDTA plasma. Adequate chromatographic separation with well-defined peaks for all eight analytes was achieved with an Acquity UPLC BEH C18 column (1. Read More

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http://dx.doi.org/10.1016/j.jchromb.2019.01.024DOI Listing
January 2019

Assessing the impacts of sewage sludge amendment containing nano-TiO on tomato plants: A life cycle study.

J Hazard Mater 2019 Feb 11;369:191-198. Epub 2019 Feb 11.

EcoLab, Université de Toulouse, CNRS, Toulouse, France. Electronic address:

Increasing evidence indicates the presence of engineered nanoparticles (ENPs) in sewage sludge derived from wastewater treatment. Land application of sewage sludge is, therefore, considered as an important pathway for ENP transfer to the environment. The aim of this work was to understand the effects of sewage sludge containing nano-TiO on plants (tomato) when used as an amendment in agricultural soil. Read More

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http://dx.doi.org/10.1016/j.jhazmat.2019.02.036DOI Listing
February 2019

Paleoecological and historical data as an important tool in ecosystem management.

J Environ Manage 2019 Feb 15;236:755-768. Epub 2019 Feb 15.

Laboratory of Wetland Ecology and Monitoring & Department of Biogeography and Paleoecology, Adam Mickiewicz University, Bogumiła Krygowskiego 10, 61-680, Poznań, Poland.

In recent decades, it has been observed that most forest fires in Europe were caused by people. Extreme droughts, which are more often prolonged, can increase the risk of forest fires, not only in southern Europe but also, in Central Europe. Nonetheless, catastrophic fire events are not well recognized in the Central European Lowlands (CEL), where large forest complexes are located. Read More

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http://dx.doi.org/10.1016/j.jenvman.2019.02.002DOI Listing
February 2019

Serotyping and antimicrobial resistance of Mannheimia haemolytica strains from European cattle with bovine respiratory disease.

Res Vet Sci 2019 Feb 12;124:10-12. Epub 2019 Feb 12.

Agriculture and Agri-Food Canada, Lethbridge Research and Development Centre, 5403 1 Ave S, Lethbridge, AB T1J 4B1, Canada. Electronic address:

The objective of this study was to assess the prevalence of three serotypes, A1, A2, and A6 in 98 M. haemolytica isolates collected from clinical BRD cases in European cattle and assess their antimicrobial resistance profiles. Isolates were characterized by serotyping (plate agglutination and serotype specific PCR) and antimicrobial susceptibility testing. Read More

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http://dx.doi.org/10.1016/j.rvsc.2018.12.021DOI Listing
February 2019

Clinically significant drug-drug interactions involving medications used for symptom control in patients with advanced malignant disease. A systematic review.

J Pain Symptom Manage 2019 Feb 15. Epub 2019 Feb 15.

Regional Centre of Excellence for Palliative Care, Western Norway, Haukeland University Hospital, Bergen, Norway; Department of Clinical Medicine K1, University of Bergen, Bergen, Norway.

Context: Most patients with advanced malignant disease need to take several drugs to control symptoms. This treatment raises risks of serious adverse effects and drug-drug interactions (DDIs).

Objectives: To identify studies reporting clinically significant DDIs involving medications used for symptom control, other than opioids used for pain management, in adult patients with advanced malignant disease. Read More

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http://dx.doi.org/10.1016/j.jpainsymman.2019.02.006DOI Listing
February 2019

The European Society for Immunodeficiencies (ESID) Registry Working Definitions for the Clinical Diagnosis of Inborn Errors of Immunity.

J Allergy Clin Immunol Pract 2019 Feb 15. Epub 2019 Feb 15.

Institute for Immunodeficiency, Center for Chronic Immunodeficiency (CCI), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany; Center for Pediatrics and Adolescent Medicine, Medical Center, Faculty of Medicine, University of Freiburg, Germany. Electronic address:

Patient registries are instrumental for clinical research in rare diseases. They help to achieve a sufficient sample size for epidemiological and clinical research and to assess the feasibility of clinical trials. The European Society for Immunodeficiencies (ESID) registry currently comprises information on >25,000 patients with inborn errors of immunity (IEI). Read More

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http://dx.doi.org/10.1016/j.jaip.2019.02.004DOI Listing
February 2019

Adaptive genetic diversifications among tick-borne encephalitis virus subtypes: A genome-wide perspective.

Virology 2019 Feb 12;530:32-38. Epub 2019 Feb 12.

College of Life Science, Sichuan Agricultural University, Yaan, People's Republic of China.

Tick-borne encephalitis (TBE) is a severe neurological illness in humans. Tick-borne encephalitis virus (TBEV), the causative agent, can be grouped into Far Eastern, Siberian, and (Western) European subtypes. These subtypes are characterized by diverse vector specificity, host range and clinical manifestations. Read More

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http://dx.doi.org/10.1016/j.virol.2019.02.006DOI Listing
February 2019

Geoepidemiology of Sjögren's syndrome in Latin America.

Joint Bone Spine 2019 Feb 15. Epub 2019 Feb 15.

Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Bogota, Colombia. Electronic address:

Objective: To evaluate the geoepidemiology of Sjögren's syndrome (SS) in Latin America.

Methods: This was a three phase study in which original data from a Colombian cohort of patients with SS is presented, followed by a systematic review of Colombian and Latin American studies. Lastly, the geoepidemiology of SS in Latin America was assessed by comparing the clinical characteristics of the region with those of the rest of the world by means of a meta-analysis approach. Read More

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http://dx.doi.org/10.1016/j.jbspin.2019.02.004DOI Listing
February 2019

Microparticles based on natural and synthetic polymers for cosmetic applications.

Int J Biol Macromol 2019 Feb 15. Epub 2019 Feb 15.

Nicolaus Copernicus University in Torun, Faculty of Chemistry, Gagarina 7, 87-100 Torun, Poland.

Most peeling products (exfoliators) available on the market, used in cosmetic and aesthetic dermatology applications, contain synthetic microbeads as abrasive agents. After being released into the natural environment, these non-biodegradable microparticles have an adverse impact on it, especially on aquatic ecosystems. Cosmetics consisting of solid plastic particles will be prohibited in the European Union from 2020. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.02.091DOI Listing
February 2019

HLA-A*32:01 is strongly associated with vancomycin-induced drug reaction with eosinophilia and systemic symptoms.

J Allergy Clin Immunol 2019 Feb 15. Epub 2019 Feb 15.

Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA, 37232; Institute for Immunology and Infectious Diseases, Murdoch University, Murdoch, Western Australia, AUS, 6150; Division of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA, 37232; Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee, USA, 37232. Electronic address:

Background: Vancomycin is a prevalent cause of the severe hypersensitivity syndrome drug reaction with eosinophilia and systemic symptoms (DRESS) which leads to significant morbidity and mortality and commonly occurs in the setting of combination antibiotic therapy which impacts future treatment choices. Variations in human leukocyte antigen (HLA) class I in particular have been associated with serious T-cell mediated adverse drug reactions which has led to preventive screening strategies for some drugs.

Objective: To determine if variation in the HLA region is associated with vancomycin-induced DRESS. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00916749193021
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http://dx.doi.org/10.1016/j.jaci.2019.01.045DOI Listing
February 2019
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Linkage disequilibrium and past effective population size in native Tunisian cattle.

Genet Mol Biol 2019 Feb 18. Epub 2019 Feb 18.

GABI, INRA, AgroParisTech, Université Paris Saclay, Jouy-en-Josas, France.

To carry out effective genome-wide association studies, information about linkage disequilibrium (LD) is essential. Here, we used medium-density SNP chips to provide estimates of LD in native Tunisian cattle. The two measures of LD that were used, mean r2 and D', decreased from 0. Read More

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http://dx.doi.org/10.1590/1678-4685-GMB-2017-0342DOI Listing
February 2019

[Prevalence of autism spectrum disorders in USA, Europe and Spain: coincidences and discrepancies].

Medicina (B Aires) 2019 ;79 Suppl 1:4-9

Unidad de Neurología Infantil, Hospital Universitario Central de Asturias, Oviedo, España.

Autism spectrum disorders are a heterogeneous group of disorders that share the presence of two core symptoms: problems in social interaction / communication and the tendency to present restricted interests and repetitive behavior. Over the last years, several epidemiologic studies have been published by different authors in diverse countries, having all of them shown two common characteristics: a global increase in the prevalence rates of autism spectrum disorders, and the existence of a great geographical variability no only between geographical areas, but also within the same geographical areas. At the present manuscript, we analyze some of the most recent prevalence data published in USA and some European countries (including Spain). Read More

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January 2019

Two-Dimensional Materials on the Rocks: Positive and Negative Role of Dopants and Impurities in Electrochemistry.

ACS Nano 2019 Feb 18. Epub 2019 Feb 18.

Center for Advanced Functional Nanorobots, Department of Inorganic Chemistry , University of Chemistry and Technology , Technicka 5 , Praha 6 166 28 , Czech Republic.

Two-dimensional (2D) materials, such as graphene and transition-metal chalcogenides, were shown in many works as very potent catalysts for industrially important electrochemical reactions, such as oxygen reduction, hydrogen and oxygen evolution, and carbon dioxide reduction. We critically discuss here the development in the field, showing that not only dopants but also impurities can have dramatic effects on catalysis. Note here that the difference between dopant and impurity is merely semantic-dopant is an impurity deliberately added to the material. Read More

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http://dx.doi.org/10.1021/acsnano.8b07795DOI Listing
February 2019

The Dual Role of Benzophenone in Visible-Light/Nickel Photoredox-Catalyzed C-H Arylations: Hydrogen-Atom Transfer and Energy Transfer.

Angew Chem Int Ed Engl 2019 Feb 18. Epub 2019 Feb 18.

Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074, Aachen, Germany.

A dual catalytic protocol for the direct arylation of non-activated C(sp )-H bonds has been developed. Upon photochemical excitation, the excited triplet state of a diaryl ketone photosensitizer abstracts a hydrogen atom from an aliphatic C-H bond. This inherent reactivity was exploited for the generation of benzylic radicals which subsequently enter a nickel catalytic cycle, accomplishing the benzylic arylation. Read More

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http://dx.doi.org/10.1002/anie.201901327DOI Listing
February 2019

A novel approach to offering additional genomic findings-A protocol to test a two-step approach in the healthcare system.

J Genet Couns 2019 Feb 18. Epub 2019 Feb 18.

Melbourne Genomics Health Alliance, Melbourne, Australia.

Internationally, the practice of offering additional findings (AFs) when undertaking a clinically indicated genomic test differs. In the USA, the recommendation is to include analysis for AFs alongside diagnostic analysis, unless a patient opts-out, whereas European and Canadian guidelines recommend opt-in models. These guidelines all consider the offer of AFs as an activity concurrent with the offer of diagnostic testing. Read More

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http://dx.doi.org/10.1002/jgc4.1102DOI Listing
February 2019

Real-world insights into risk of developing cardiovascular disease following GnRH agonists versus antagonists for prostate cancer: a methodological protocol to a study using five European databases.

Fundam Clin Pharmacol 2019 Feb 18. Epub 2019 Feb 18.

King's College London, Translational Oncology and Urology Research, London, United Kingdom.

One of the more recently investigated adverse long-term side effects of gonadotropin-releasing hormone (GnRH) agonists for prostate cancer (PCa) is cardiovascular disease (CVD). Studies suggest lower risk of CVD following GnRH antagonists (degarelix) than GnRH agonists. This protocol describes precise codes used to extract variables from five European databases for a study that compares risk of CVD following GnRH agonists and antagonists for PCa. Read More

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http://dx.doi.org/10.1111/fcp.12454DOI Listing
February 2019

T-VEC in advanced Melanoma - Complete response in a heart and kidney transplant patient: A case report.

Br J Dermatol 2019 Feb 18. Epub 2019 Feb 18.

Departments of 1Dermatology and 2Surgery, Medical University of Vienna, Vienna, Austria.

Talimogene laherparepvec (T-VEC) is a intralesional oncolytic virotherapy, licensed in the European Union (EU) for locoregional advanced melanoma of American Joint Committee on Cancer (AJCC) stages IIIB, IIIC and IVM1a. Organ transplant recipients (OTRs) are so far excluded from all clinical trials dealing with immunotherapies due to the risk of transplant rejection. A 58-year-old caucasian male with a history of a heart and kidney transplantation in 2014 was diagnosed with melanoma (Breslow thickness of 1. Read More

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http://dx.doi.org/10.1111/bjd.17783DOI Listing
February 2019

Connectivity Between Brain Networks Dynamically Reflects Cognitive Status of Parkinson's Disease: A Longitudinal Study.

J Alzheimers Dis 2019 ;67(3):971-984

Applied Neuroscience Research Group, Central European Institute of Technology, Masaryk University (CEITEC MU), Brno, Czech Republic.

Background: Cognitive impairment in Parkinson's disease (PD) is associated with altered connectivity of the resting state networks (RSNs). Longitudinal studies in well cognitively characterized PD subgroups are missing.

Objectives: To assess changes of the whole-brain connectivity and between-network connectivity (BNC) of large-scale functional networks related to cognition in well characterized PD patients using a longitudinal study design and various analytical methods. Read More

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http://dx.doi.org/10.3233/JAD-180834DOI Listing
January 2019

Head-to-Head Comparison among Semi-Quantification Tools of Brain FDG-PET to Aid the Diagnosis of Prodromal Alzheimer's Disease.

J Alzheimers Dis 2019 Feb 13. Epub 2019 Feb 13.

Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, and Mother-Child health (DINOGMI), University of Genoa, Italy.

Background: Several automatic tools have been implemented for semi-quantitative assessment of brain [18]F-FDG-PET.

Objective: We aimed to head-to-head compare the diagnostic performance among three statistical parametric mapping (SPM)-based approaches, another voxel-based tool (i.e. Read More

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http://dx.doi.org/10.3233/JAD-181022DOI Listing
February 2019

Nuclear genetic regulation of the human mitochondrial transcriptome.

Elife 2019 Feb 18;8. Epub 2019 Feb 18.

Department of Medical and Molecular Genetics, King's College London, London, United Kingdom.

Mitochondria play important roles in cellular processes and disease, yet little is known about how the transcriptional regime of the mitochondrial genome varies across individuals and tissues. By analyzing >11,000 RNA-sequencing libraries across 36 tissue/cell types, we find considerable variation in mitochondrial-encoded gene expression along the mitochondrial transcriptome, across tissues and between individuals, highlighting the importance of cell-type specific and post-transcriptional processes in shaping mitochondrial-encoded RNA levels. Using whole-genome genetic data we identify 64 nuclear loci associated with expression levels of 14 genes encoded in the mitochondrial genome, including missense variants within genes involved in mitochondrial function (, and ), implicating genetic mechanisms that act in across the two genomes. Read More

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http://dx.doi.org/10.7554/eLife.41927DOI Listing
February 2019

Mitochondrial biogenesis is transcriptionally repressed in lysosomal lipid storage diseases.

Elife 2019 Feb 18;8. Epub 2019 Feb 18.

Institute of Cellular Biochemistry, University Medical Center Goettingen, Goettingen, Germany.

Perturbations in mitochondrial function and homeostasis are pervasive in lysosomal storage diseases, but the underlying mechanisms remain unknown. Here, we report a transcriptional program that represses mitochondrial biogenesis and function in lysosomal storage diseases Niemann-Pick type C (NPC) and acid sphingomyelinase deficiency (ASM), in patient cells and mouse tissues. This mechanism is mediated by the transcription factors KLF2 and ETV1, which are both induced in NPC and ASM patient cells. Read More

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http://dx.doi.org/10.7554/eLife.39598DOI Listing
February 2019

LiSEQ - whole-genome sequencing of a cross-sectional survey of Listeria monocytogenes in ready-to-eat foods and human clinical cases in Europe.

Microb Genom 2019 Feb 18. Epub 2019 Feb 18.

2​National Institute for Health Research Health Protection Research Unit (NIHR HPRU) in Gastrointestinal Infections at University of Liverpool, Liverpool, UK.

We present the LiSEQ (Listeria SEQuencing) project, funded by the European Food Safety Agency (EFSA) to compare Listeria monocytogenes isolates collected in the European Union from ready-to-eat foods, compartments along the food chain (e.g. food-producing animals, food-processing environments) and humans. Read More

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http://dx.doi.org/10.1099/mgen.0.000257DOI Listing
February 2019

Cerebral oxygenation associated with INSURE versus LISA procedures in surfactant-deficient newborn piglet RDS model.

Pediatr Pulmonol 2019 Feb 18. Epub 2019 Feb 18.

Neonatal Intensive Care Unit, Cruces University Hospital, Barakaldo, Bizkaia, Spain.

Background: Nasal continuous-positive airway pressure (nCPAP) with the INSURE (INtubation-SURfactant-Extubation) or LISA (Less-Invasive Surfactant Administration) procedures are increasingly being chosen as the initial treatment for neonates with surfactant deficiency. Our objective was to compare the effects on cerebral oxygenation of different methods for surfactant administration: INSURE and LISA, using a nasogastric tube (NT) or a LISAcath® catheter, in spontaneously breathing SF-deficient newborn piglets.

Methods: Eighteen newborn piglets with SF-deficient lung injury produced by repetitive bronchoalveolar lavages were randomly assigned to INSURE, LISA-NT, or LISAcath® groups. Read More

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http://dx.doi.org/10.1002/ppul.24277DOI Listing
February 2019

Evaluation of a cognitive-behavioral intervention for high- and medium-risk probationers.

Behav Sci Law 2019 Feb 18. Epub 2019 Feb 18.

19th Circuit Court of Illinois, Waukegan, IL, USA.

Reducing recidivism is a central goal of treatment programs for offenders. Preliminary evidence suggests that cognitive-behavioral group interventions based on the National Institute of Corrections curriculum (Bush, Glick, & Taymans, ) may be effective in reducing recidivism rates among adult probationers. We evaluated the effectiveness of a program based on this curriculum among 167 high- and medium-risk probationers assigned to this program and a comparison group of 120 high- and medium-risk probationers matched on age and number of prior criminal charges. Read More

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http://dx.doi.org/10.1002/bsl.2394DOI Listing
February 2019

Seasonal succession of tabanid species in equine infectious anaemia endemic areas of Italy.

Med Vet Entomol 2019 Feb 18. Epub 2019 Feb 18.

Direction départementale de la protection des populations du Nord, Lille, France.

Equine infectious anaemia (EIA) is a disease with an almost worldwide distribution, with several outbreaks having been reported recently in European countries. In Italy, two regions, Lazio and Abruzzo, are considered as endemic areas for this disease. In nature, the EIA virus is mechanically transmitted by biting flies such as tabanids (Diptera: Tabanidae), although few studies have investigated the epidemiological implications. Read More

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http://dx.doi.org/10.1111/mve.12360DOI Listing
February 2019

Respiratory patterns of European pear ( L. 'Conference') throughout pre- and post-harvest fruit development.

Heliyon 2019 Jan 30;5(1):e01160. Epub 2019 Jan 30.

Leibniz Institute for Agricultural Engineering and Bioeconomy (ATB), Max-Eyth-Allee 100, 14469 Potsdam, Germany.

Information on the developmental stage of pear pre-harvest and in shelf-life is crucial to determine the optimum timing of harvest, post-harvest treatment, and time of consumption ensuring high eating quality. In the present study, CO emission and fruit quality of European pear ( L.) 'Conference' were analysed pre- and post-harvest with emphasis on shelf life for three years. Read More

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http://dx.doi.org/10.1016/j.heliyon.2019.e01160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357215PMC
January 2019

Mechanistic insights into the evolution of DUF26-containing proteins in land plants.

Commun Biol 2019 8;2:56. Epub 2019 Feb 8.

1Organismal and Evolutionary Biology Research Programme, Viikki Plant Science Centre, VIPS, Faculty of Biological and Environmental Sciences, University of Helsinki, Viikinkaari 1 (POB65), FI-00014 Helsinki, Finland.

Large protein families are a prominent feature of plant genomes and their size variation is a key element for adaptation. However, gene and genome duplications pose difficulties for functional characterization and translational research. Here we infer the evolutionary history of the DOMAIN OF UNKNOWN FUNCTION (DUF) 26-containing proteins. Read More

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http://dx.doi.org/10.1038/s42003-019-0306-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368629PMC
February 2019

Distribution of CO in Western Pacific, Studied Using Isotope Data Made in Taiwan, OCO-2 Satellite Retrievals, and CarbonTracker Products.

Earth Space Sci 2018 Nov 29;5(11):827-842. Epub 2018 Nov 29.

Research Center for Environmental Changes, Academia Sinica Taipei Taiwan.

To assess sources and processes that affect the variability of CO at local to regional scales, we have analyzed the mixing ratio [CO] and stable isotopic compositions (δC and δO) of atmospheric CO for three years (2014-2016) in urban and sub-urban areas in Taipei, Taiwan. The data are compared with those from some background sites, viz., Lulin, Mauna Loa, and Minamitorishima, to evaluate how local emissions affect CO level regionally. Read More

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http://dx.doi.org/10.1029/2018EA000415DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360507PMC
November 2018

European Respiratory Society International Congress, Paris, 2018: highlights from the Clinical Assembly.

ERJ Open Res 2019 Feb 11;5(1). Epub 2019 Feb 11.

Dept of Pneumology and Critical Care Medicine, Thoraxklinik, Heidelberg University Hospital, Heidelberg, Germany.

This article contains highlights and a selection of the scientific advances from the European Respiratory Society's Clinical Assembly (Assembly 1 and its five respective groups) that were presented at the 2018 European Respiratory Society International Congress in Paris, France. The most relevant topics from each of the groups will be discussed, covering a wide range of areas including clinical problems, rehabilitation and chronic care, thoracic imaging, interventional pulmonology, and general practice and primary care. The newest research, actual data and highlight sessions will be discussed. Read More

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http://dx.doi.org/10.1183/23120541.00176-2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368995PMC
February 2019

TiO ALD Coating of Amorphous TiO Nanotube Layers: Inhibition of the Structural and Morphological Changes Due to Water Annealing.

Front Chem 2019 1;7:38. Epub 2019 Feb 1.

Central European Institute of Technology, Brno University of Technology, Brno, Czechia.

The present work presents a strategy to stabilize amorphous anodic self-organized TiO nanotube layers against morphological changes and crystallization upon extensive water soaking. The growth of needle-like nanoparticles was observed on the outer and inner walls of amorphous nanotube layers after extensive water soakings, in line with the literature on water annealing. In contrary, when TiO nanotube layers uniformly coated by thin TiO using atomic layer deposition (ALD) were soaked in water, the growth rates of needle-like nanoparticles were substantially reduced. Read More

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http://dx.doi.org/10.3389/fchem.2019.00038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367259PMC
February 2019

Efficacy and cost-effectiveness of guided and unguided internet- and mobile-based indicated transdiagnostic prevention of depression and anxiety (ICare Prevent): A three-armed randomized controlled trial in four European countries.

Internet Interv 2019 Apr 15;16:52-64. Epub 2018 Apr 15.

Department of Clinical Psychology and Psychotherapy, Nägelsbachstraße 25a, Germany.

Background: Depression and anxiety are highly prevalent and often co-occur. Several studies indicate the potential of disorder-specific psychological interventions for the prevention of each of these disorders. To treat comorbidity, transdiagnostic treatment concepts seem to be a promising approach, however, evidence for transdiagnostic concepts of prevention remains inconclusive. Read More

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http://dx.doi.org/10.1016/j.invent.2018.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364519PMC

Web-based indicated prevention of common mental disorders in university students in four European countries - Study protocol for a randomised controlled trial.

Internet Interv 2019 Apr 15;16:35-42. Epub 2018 Mar 15.

King's College London, Institute of Psychiatry, Psychology and Neuroscience, Section of Eating Disorders, PO59, 16 De Crespigny Park, London SE5 8AF, United Kingdom.

Background: Mental disorders and their symptoms are highly prevalent in the university student population, and the transition from secondary to tertiary education is associated with a rise in mental health problems. Existing web-based interventions for the prevention of common mental disorders in student populations often focus on just one disorder and have not been designed specifically for students. There is thus a need for transdiagnostic, student-specific preventative interventions that can be widely disseminated. Read More

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http://dx.doi.org/10.1016/j.invent.2018.02.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364328PMC

The effect of enzyme replacement therapy on clinical outcomes in male patients with Fabry disease: A systematic literature review by a European panel of experts.

Mol Genet Metab Rep 2019 Jun 6;19:100454. Epub 2019 Feb 6.

Department of Paediatrics, University of Torino, Torino, Italy.

Background: Enzyme replacement therapy (ERT) with recombinant human α-galactosidase has been available for the treatment of Fabry disease since 2001 in Europe and 2003 in the USA. Treatment outcomes with ERT are dependent on baseline patient characteristics, and published data are derived from heterogeneous study populations.

Methods: We conducted a comprehensive systematic literature review of all original articles on ERT in the treatment of Fabry disease published up until January 2017. Read More

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http://dx.doi.org/10.1016/j.ymgmr.2019.100454DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365982PMC

Polarization induced contrast X-ray fluorescence at submicrometer resolution reveals nanometer apatite crystal orientations across entire tooth sections.

Biomed Opt Express 2019 Jan 3;10(1):18-28. Epub 2018 Dec 3.

Department for Operative and Preventive Dentistry, Charité - Universitätsmedizin Berlin, Aßmannshauser Str. 4-6 Berlin 14197, Germany.

For biomedical research, successful imaging of calcified microstructures often relies on absorption differences between features, or on employing dies with selective affinity to areas of interest. When texture is concerned, e.g. Read More

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http://dx.doi.org/10.1364/BOE.10.000018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363201PMC
January 2019

Molecular markers and prediction of response to immunotherapy in non-small cell lung cancer, an update.

J Thorac Dis 2019 Jan;11(Suppl 1):S25-S36

Department of Biochemistry, Unit of Pharmacogenetics and Molecular Oncology, Georges Pompidou European Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.

Immunotherapy represents one of the most promising therapeutic approaches in lung cancer, however 50% of lung cancer patients will not respond to this treatment, while others will have transitory or durable responses. Because side effects may be life threatening and treatment costs remain very high, the identification of predictive markers is mandatory and actually extensively studied. Factors that determine response to immune checkpoint inhibitors (ICI) are numerous including tumor microenvironment, immune tumor infiltrates, expression of immune checkpoint proteins (PD-1/PD-L1), gene expression signatures and molecular tumor profiles. Read More

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http://dx.doi.org/10.21037/jtd.2018.12.48DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353739PMC
January 2019

Qualitative evidence synthesis for complex interventions and guideline development: clarification of the purpose, designs and relevant methods.

BMJ Glob Health 2019 25;4(Suppl 1):e000882. Epub 2019 Jan 25.

School of Social Sciences, Bangor University, Bangor, UK.

This paper is one of a series exploring the implications of complexity for systematic reviews and guideline development, commissioned by the WHO. The paper specifically explores the role of qualitative evidence synthesis. Qualitative evidence synthesis is the broad term for the group of methods used to undertake systematic reviews of qualitative research evidence. Read More

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http://dx.doi.org/10.1136/bmjgh-2018-000882DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350756PMC
January 2019

Taking account of context in systematic reviews and guidelines considering a complexity perspective.

BMJ Glob Health 2019 25;4(Suppl 1):e000840. Epub 2019 Jan 25.

School of Social Sciences, Bangor University, Wales, UK.

Systematic review teams and guideline development groups face considerable challenges when considering context within the evidence production process. Many complex interventions are context-dependent and are frequently evaluated within considerable contextual variation and change. This paper considers the extent to which current tools used within systematic reviews and guideline development are suitable in meeting these challenges. Read More

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http://dx.doi.org/10.1136/bmjgh-2018-000840DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350703PMC
January 2019

Enhanced germinal center reaction by targeting vaccine antigen to major histocompatibility complex class II molecules.

NPJ Vaccines 2019 11;4. Epub 2019 Feb 11.

K.G. Jebsen Centre for Influenza Vaccine Research, Institute of Clinical Medicine, University of Oslo, N-0027 Oslo, Norway.

Enhancing the germinal center (GC) reaction is a prime objective in vaccine development. Targeting of antigen to MHCII on APCs has previously been shown to increase antibody responses, but the underlying mechanism has been unclear. We have here investigated the GC reaction after targeting antigen to MHCII in (i) a defined model with T and B cells of known specificity using adjuvant-free vaccine proteins, and (ii) an infectious disease model using a DNA vaccine. Read More

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http://dx.doi.org/10.1038/s41541-019-0101-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370881PMC
February 2019

A phenome-wide association study to discover pleiotropic effects of , , and .

NPJ Genom Med 2019 11;4. Epub 2019 Feb 11.

1Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN 55905 USA.

We conducted an electronic health record (EHR)-based phenome-wide association study (PheWAS) to discover pleiotropic effects of variants in three lipoprotein metabolism genes , , and . Using high-density genotype data, we tested the associations of variants in the three genes with 1232 EHR-derived binary phecodes in 51,700 European-ancestry (EA) individuals and 585 phecodes in 10,276 African-ancestry (AA) individuals; 457 , 730 , and 720 variants were filtered by imputation quality ( > 0.4), minor allele frequency (>1%), linkage disequilibrium ( < 0. Read More

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http://dx.doi.org/10.1038/s41525-019-0078-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370860PMC
February 2019

Constipation, deficit in colon contractions and alpha-synuclein inclusions within the colon precede motor abnormalities and neurodegeneration in the central nervous system in a mouse model of alpha-synucleinopathy.

Transl Neurodegener 2019 6;8. Epub 2019 Feb 6.

1Bio@SNS Laboratory, Scuola Normale Superiore, Piazza dei Cavalieri 7, 56126 Pisa, Italy.

Background: Gastrointestinal dysfunction can affect Parkinson's disease (PD) patients long before the onset of motor symptoms. However, little is known about the relationship between gastrointestinal abnormalities and the development of PD. Contrary to other animal models, the human A53T alpha-synuclein (αS) transgenic mice, Line G2-3, develops αS-driven neurological and motor impairments after 9 months of age, displaying a long presymptomatic phase free of central nervous system (CNS) dysfunction. Read More

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http://dx.doi.org/10.1186/s40035-019-0146-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364448PMC
February 2019

Contribution of promoter region gene polymorphism to early-onset prostate cancer risk in Mexican males.

Oncotarget 2019 Jan 22;10(7):738-748. Epub 2019 Jan 22.

Departamento de Toxicología, Cinvestav-IPN, Mexico City, Mexico.

Sexually transmitted infections and its contribution to prostate cancer (PC) development have been relevant in different populations. gene polymorphism (rs10993994) has exhibited an association both with PC as well as the susceptibility to sexually transmitted infections. Hitherto, these conditions have been not studied in Mexico yet, neither if sexually transmitted infections could modify the MSMB and PC association. Read More

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http://dx.doi.org/10.18632/oncotarget.26592DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366823PMC
January 2019

Insights into the Synthesis Mechanism of Ag Nanoclusters.

J Phys Chem C Nanomater Interfaces 2018 Dec 19;122(49):28351-28361. Epub 2018 Nov 19.

Inorganic Chemistry and Catalysis, Debye Institute for Nanomaterials Science, Utrecht University, Universiteitslaan 99, 3584 CG Utrecht, The Netherlands.

The current understanding of the synthesis mechanisms of noble metal clusters is limited, in particular for Ag clusters. Here, we present a detailed investigation into the synthesis process of atomically monodisperse Ag clusters, prepared via reduction of AgNO in the presence of dithiolate ligands. Using optical spectroscopy, mass spectrometry, and X-ray spectroscopy, it was determined that the synthesis involves a rapid nucleation and growth to species with up to a few hundred Ag atoms. Read More

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http://dx.doi.org/10.1021/acs.jpcc.8b09360DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369667PMC
December 2018

Homework and Academic Achievement in Latin America: A Multilevel Approach.

Front Psychol 2019 1;10:95. Epub 2019 Feb 1.

Department of Psychology, University of Oviedo, Oviedo, Spain.

The relationship between homework and academic results has been widely researched. Most of that research has used English-speaking, European or Asian samples, and to date there have been no detailed studies into that relationship in Latin America and the Caribbean. The aim of this study is to examine the effect of quantitative homework characteristics on achievement in science. Read More

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http://dx.doi.org/10.3389/fpsyg.2019.00095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367234PMC
February 2019

Assessing the 2004-2018 Fentanyl Misusing Issues Reported to an International Range of Adverse Reporting Systems.

Front Pharmacol 2019 1;10:46. Epub 2019 Feb 1.

Psychopharmacology, Drug Misuse and Novel Psychoactive Substances Research Unit, School of Life and Medical Sciences, University of Hertfordshire, Hatfield, United Kingdom.

A recent, global, increase in the use of opioids including the prescribing, highly potent, fentanyl has been recorded. Due its current popularity and the potential lethal consequences of its intake, we aimed here at analyzing the fentanyl misuse, abuse, dependence and withdrawal-related adverse drug reactions (ADRs) identified within the European Medicines Agency (EMA), the United Kingdom Yellow Card Scheme (YCS), and the United States Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS) databases. Descriptive analysis of both ADRs and related cases. Read More

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http://dx.doi.org/10.3389/fphar.2019.00046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367955PMC
February 2019

The effect of lercanidipine or lercanidipine/enalapril combination on blood pressure in treatment-naïve patients with stage 1 or 2 systolic hypertension.

Authors:
Brian Rayner

Pragmat Obs Res 2019 22;10:9-14. Epub 2019 Jan 22.

Kidney and Hypertension Research Unit, University of Cape Town, Groote Schuur Hospital, Observatory, Cape Town 7925, South Africa,

Purpose: To describe the efficacy of a stratified approach on automatic office blood pressure (BP), 24-hour ambulatory BP, and BP variability (BPV) in treatment-naïve patients with systolic hypertension using lercanidipine for stage 1 and lercanidipine/enalapril for stage 2.

Patients And Methods: This was an open-label, prospective interventional study conducted in 22 general practices in South Africa. Treatment-naïve patients with stage 1 hypertension received lercanidipine 10 mg and patients with stage 2 received lercanidipine 10 mg/enalapril 10 mg. Read More

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http://dx.doi.org/10.2147/POR.S186070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349075PMC
January 2019

Effect of kiwifruit on metabolic health in patients with cardiovascular risk factors: a systematic review and meta-analysis.

Diabetes Metab Syndr Obes 2019 23;12:171-180. Epub 2019 Jan 23.

Department of Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand.

Background: Kiwifruit seems to have beneficial effect on metabolic health because it contains abundant phytochemicals and antioxidants. This study aimed to assess the effect of kiwifruit on metabolic health in participants with cardiovascular risk factors.

Methods: Literature was searched from PubMed, CENTRAL, Cumulative Index to Nursing and Allied Health Literature, Web of Science, Scopus, Proquest, Latin American and Carib-bean Health Sciences Literature, International Clinical Trials Registry Platform, Australia New Zealand Clinical Trials Registry, https://clinicaltrials. Read More

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http://dx.doi.org/10.2147/DMSO.S193225DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350646PMC
January 2019