9,505 results match your criteria European Journal of Pediatrics[Journal]


Energy drinks in children and adolescents: demographic data and immediate effects.

Eur J Pediatr 2019 Feb 15. Epub 2019 Feb 15.

Pediatric Department, Saint Vincent De Paul Hospital, Faculty of Medicine, Bar-Ilan University, PO box 50294, 16102, Nazareth, Israel.

Energy drinks consumption has become increasingly common in the last few years, despite evidence associating these products with vast adverse health effects. This led us to explore the phenomenon of energy drinks consumption in adolescents in the Israeli Arab population of the Nazareth area (Northern Israel), examining their awareness of risks associated with consumption of energy drinks, investigating their immediate effects on the body. Our study revealed that the consumption of energy drinks is very common in adolescents of both sexes, though more common in boys. Read More

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http://dx.doi.org/10.1007/s00431-019-03342-7DOI Listing
February 2019

Epidemiological and clinical characteristics and the approach to infant chickenpox in primary care.

Eur J Pediatr 2019 Feb 14. Epub 2019 Feb 14.

Primary health care Miralbueno, Servicio Aragonés de Salud, Zaragoza, Spain.

Chickenpox is not common in the first year of life (infant varicella) and there is a lack of data on its presentation, especially in primary care. A year-long observational study (July 2015-2016) carried out by a research network of primary care pediatricians throughout Spain.Two hundred and sixty-four pediatricians gathered data from 358 cases of clinically diagnosed chickenpox in infants. Read More

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http://dx.doi.org/10.1007/s00431-019-03332-9DOI Listing
February 2019

Skeletal disproportion in glucocorticoid-treated boys with Duchenne muscular dystrophy.

Eur J Pediatr 2019 Feb 14. Epub 2019 Feb 14.

Developmental Endocrinology Research Group, Royal Hospital for Children, 1345 Govan Road, G51 4TF, Glasgow, UK.

We aimed to compare body segment and bone lengths in glucocorticoid-treated boys with Duchenne muscular dystrophy (DMD) with healthy controls using dual-energy absorptiometry (DXA) images. Total height (Ht), sitting height (SH), leg length (LL) and bone lengths (femur, tibia) in boys with DMD and age-matched control boys were measured using DXA. Thirty boys with DMD (median age 10. Read More

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http://dx.doi.org/10.1007/s00431-019-03336-5DOI Listing
February 2019
1.983 Impact Factor

Point-of-care lung ultrasound in infants with bronchiolitis in the pediatric emergency department: a prospective study.

Eur J Pediatr 2019 Feb 12. Epub 2019 Feb 12.

Emergency Pediatric Department, Institute for Research and Health Care (IRCCS), Bambino Gesù Children's Hospital, Piazza Sant'Onofrio 4, 00165, Rome, Italy.

Bronchiolitis is the most common cause of hospitalization of children in the first year of life. The lung ultrasound is a new diagnostic tool which is inexpensive, non-invasive, rapid, and easily repeatable. Our prospective study was conducted in the emergency department and all patients underwent a routine clinical evaluation and lung ultrasound by the pediatricians who defined the clinical and the ultrasound score. Read More

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http://dx.doi.org/10.1007/s00431-019-03335-6DOI Listing
February 2019
1 Read

Growth impairment and limited range of joint motion in children should raise suspicion of an attenuated form of mucopolysaccharidosis: expert opinion.

Eur J Pediatr 2019 Feb 11. Epub 2019 Feb 11.

Groupe de Pédiatrie Générale - Société Française de Pédiatrie, Boulogne-Billancourt, Department of Pediatrics and Pediatric Emergency, Ambroise-Paré Hospital, Boulogne-Billancourt, France.

Growth impairment together with bone and joint involvement is common to most patients with mucopolysaccharidosis (MPS) disorders. The genetic basis for these metabolic disorders involves various enzyme deficiencies responsible for the catabolism of glycosaminoglycans (GAGs). The incomplete degradation and subsequent accumulation of GAGs result in progressive tissue damage throughout the body. Read More

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http://dx.doi.org/10.1007/s00431-019-03330-xDOI Listing
February 2019

Pyogenic sacroiliitis in children: don't forget the very young.

Eur J Pediatr 2019 Feb 7. Epub 2019 Feb 7.

Department of Pediatrics, Mount Scopus Hadassah-Hebrew University Medical Center, 91120, Jerusalem, Israel.

Pyogenic sacroiliitis (PS) is rare with less than 100 pediatric cases reported in the medical literature. To better characterize PS in the pediatric population, we investigated a series of children presenting with PS. Retrospective data analysis was done at an academic tertiary center between the years of 2000 and 2017. Read More

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http://dx.doi.org/10.1007/s00431-019-03333-8DOI Listing
February 2019
2 Reads

A quick and qualitative assessment of gross motor development in preschool children.

Eur J Pediatr 2019 Feb 7. Epub 2019 Feb 7.

Child Development Center, University Children's Hospital Zürich, Steinwiesstrasse 75, CH-8032, Zürich, Switzerland.

There is a need for a quick, qualitative, reliable, and easy tool to assess gross motor development for practitioners. The aim of this cross-sectional study is to present the Zurich Neuromotor Assessment-Q (ZNA-Q), which assesses static and dynamic balance in children between 3 and 6 years of age in less than 5 min. A total of 216 children (103 boys; 113 girls; median age 4 years, 4 months; interquartile range 1 year, 3 months) were enrolled from day-care centers, kindergartens, and schools, and were tested with 5 different gross motor tasks: standing on one leg, tandem stance, hopping on one leg, walking on a straight line, and jumping sideways. Read More

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http://dx.doi.org/10.1007/s00431-019-03327-6DOI Listing
February 2019

Developmental dysplasia of the hip in children with Down syndrome: comparison of clinical and radiological examinations in a local cohort.

Eur J Pediatr 2019 Feb 1. Epub 2019 Feb 1.

Department of Pediatrics and Neonatology, Máxima Medical Center, PO Box no. 7777, 5500, MB, Veldhoven, The Netherlands.

Guidelines for children with Down syndrome (DS) suggest to perform an annual hip screening to enable early detection of developmental dysplasia of the hip (DDH). How to perform this screening is not described. Delayed detection can result in disabling osteoarthritis of the hip. Read More

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http://dx.doi.org/10.1007/s00431-019-03322-xDOI Listing
February 2019

Preliminary study on bisphenol A levels and possible exposure history of mother and exclusively breastfed infant pairs.

Eur J Pediatr 2019 Feb 1. Epub 2019 Feb 1.

School of Medicine, Department of Pediatrics, Division of Social Pediatrics, Ankara University, Dikimevi, 06100, Ankara, Turkey.

The aims of this study were to determine bisphenol A (BPA) levels in breast milk and urine specimens of healthy mother and exclusively breastfed infant pairs having no known BPA exposure, and also to examine the relationship between BPA levels and possible BPA exposure history. Forty mothers and their 1-2-month-old exclusively breastfeed infant were included in the study. The questionnaires about sociodemographic characteristics and possible BPA exposure history were filled out. Read More

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http://dx.doi.org/10.1007/s00431-019-03329-4DOI Listing
February 2019

Thromboelastometry: studying hemostatic profile in small for gestational age neonates-a pilot observational study.

Eur J Pediatr 2019 Feb 1. Epub 2019 Feb 1.

Laboratory of Haematology and Blood Bank Unit, "Attiko" Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.

Scarce data exists about the hemostatic status of small for gestational age (SGA) neonates. We aimed at evaluating the hemostatic profile of SGA neonates, using thromboelastometry (TEM). This is an observational study performed in a Greek tertiary General Hospital during an 18-month period. Read More

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http://dx.doi.org/10.1007/s00431-019-03331-wDOI Listing
February 2019
1 Read

Renal tubular markers as screening tools for severe vesicoureteral reflux.

Eur J Pediatr 2019 Jan 31. Epub 2019 Jan 31.

Pediatric Nephrology Division, University of Florida, Gainesville, FL, USA.

Severe (grades IV and V) vesicoureteral reflux (VUR) is a risk factor for acute pyelonephritis, renal scars, and renal failure. This study evaluates albumin and N-acetylglucosaminidase (NAG) urinary excretion, and renal concentrating ability as screening tools to select patients for voiding cystourethrogram (VCUG). Children (111 M, 52 F) aged 10. Read More

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http://dx.doi.org/10.1007/s00431-019-03324-9DOI Listing
January 2019
1 Read

Knowledge and practices regarding infant vaccination: results of a survey of French physicians.

Eur J Pediatr 2019 Jan 31. Epub 2019 Jan 31.

IFOP Healthcare, 78 rue Championnet, 75018, Paris, France.

A prospective, observational, survey of pediatricians and general practitioners (GPs) was conducted to assess pediatric vaccination knowledge and practices. The survey was distributed by email to 1069 pediatricians and 1700 GPs and completed by 151 pediatricians (14.1%) and 201 GPs (11. Read More

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http://dx.doi.org/10.1007/s00431-018-03314-3DOI Listing
January 2019

Metabolic liver diseases presenting with neonatal cholestasis: at the crossroad between old and new paradigms.

Eur J Pediatr 2019 Jan 28. Epub 2019 Jan 28.

Pediatric Gastroenterology Unit, Centro Materno Infantil do Norte - CMIN, Centro Hospitalar Universitário do Porto, Largo da Maternidade de Júlio Dinis, 4050-651, Porto, Portugal.

Metabolic liver diseases (MLD) are an important group of disorders presenting with neonatal cholestasis (NC). The spectrum of liver involvement is wide and the presumptive diagnosis is traditionally based on clinical and laboratory findings. Recently, next-generation sequencing (NGS) panels have emerged as an appealing tool to diagnose neonatal/infantile cholestatic disorders. Read More

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http://dx.doi.org/10.1007/s00431-019-03328-5DOI Listing
January 2019
1 Read

Correction to: Mealtime insulin bolus adherence and glycemic control in adolescents on insulin pump therapy.

Eur J Pediatr 2019 Jan 25. Epub 2019 Jan 25.

Isala Women and Children's Hospital, Zwolle, The Netherlands.

The Abstract section and the in the Results sections of the original version of this article, unfortunately, contained errors. The correct data are now shown in this article. Read More

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http://dx.doi.org/10.1007/s00431-019-03325-8DOI Listing
January 2019

Extended spectrum beta-lactamase-producing Klebsiella pneumoniae outbreak reveals incubators as pathogen reservoir in neonatal care center.

Eur J Pediatr 2019 Jan 23. Epub 2019 Jan 23.

Hydrosciences Montpellier, IRD, CNRS, Univ Montpellier, Département d'Hygiène Hospitalière, CHU Montpellier, 15 avenue Charles Flahault, BP 14491, 34093, Montpellier cedex 5, France.

In the context of a 3-month extended-spectrum beta-lactamase-producing Klebsiella pneumonia (ESBL-KP) outbreak in a neonatal care center (NCC), hygiene practices and hospital environment were investigated. ESBL-KP strains isolated from patients and environment were compared by molecular typing. The density of incidence of multi-drug-resistant bacteria (MDRB) was calculated from January 2014 to September 2016. Read More

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http://link.springer.com/10.1007/s00431-019-03323-w
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http://dx.doi.org/10.1007/s00431-019-03323-wDOI Listing
January 2019
8 Reads

Use of ketamine by paediatricians in Italian paediatric emergency departments: a missed opportunity?

Eur J Pediatr 2019 Jan 22. Epub 2019 Jan 22.

Department of Pediatrics, Institute for Maternal and Child Health-IRCCS 'Burlo Garofolo', Trieste, Italy.

Procedural sedation and analgesia with ketamine are part of daily practice for children undergoing painful procedures in the paediatric emergency department (ED) of North America. A massive number of studies demonstrate ketamine's safety and efficacy in the hands of trained ED paediatricians, with few severe adverse events (SAEs) recorded. Since there are no data on ketamine's usage in Italian paediatric EDs, we created a survey to examine procedural sedation with ketamine in the EDs of the Italian PIPER (Pain in Paediatric Emergency Room) group, which includes 36 paediatric EDs providing 1. Read More

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http://link.springer.com/10.1007/s00431-019-03320-z
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http://dx.doi.org/10.1007/s00431-019-03320-zDOI Listing
January 2019
2 Reads

Early discharge of premature infants < 37 weeks gestational age with nasogastric tube feeding: the new standard of care?

Eur J Pediatr 2019 Jan 22. Epub 2019 Jan 22.

Department of Pediatrics, Albert Schweitzer Hospital (ASH), Dordrecht, The Netherlands.

Most premature infants are hospitalised until they no longer need monitoring of vital parameters and are independent of nasogastric tube feeding (NTF). Hospital admission time easily reaches a length of multiple months in extremely preterm infants, but also in late preterms, in whom drinking may be the only problem, hospital admission time can reach weeks. This is a very stressful time for both parents and child. Read More

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http://link.springer.com/10.1007/s00431-018-03313-4
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http://dx.doi.org/10.1007/s00431-018-03313-4DOI Listing
January 2019
3 Reads

Lung ultrasound findings in congenital diaphragmatic hernia.

Eur J Pediatr 2019 Jan 21. Epub 2019 Jan 21.

Division of Neonatology, Careggi University Hospital of Florence, Largo Brambilla, 3, 50134, Florence, Italy.

Congenital diaphragmatic hernia (CDH) occurs in approximately 1 in 2500 to 5000 infants. The use of lung ultrasound (LUS) for its diagnosis has been reported in only two case reports. The aim of this study was to report the LUS pattern of CDH in a case series of infants with respiratory distress. Read More

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http://dx.doi.org/10.1007/s00431-019-03321-yDOI Listing
January 2019
1 Read

Sleep and new media usage in toddlers.

Eur J Pediatr 2019 Jan 16. Epub 2019 Jan 16.

Novella Fronda Foundation for Studies and Applied Clinical Research in the Field of Addiction Medicine, Padua, Italy.

Several studies over the years have demonstrated the association between lack of sleep in children and certain physical, psychological, and behavioral disorders. The aim of this study was to disentangle the association between new screen-based electronic devices and sleep problems in toddlers, adjusting for other covariates already known to be associated with sleep quality. We conducted a cross-sectional study with the aid of a national sample of 1117 toddlers. Read More

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http://dx.doi.org/10.1007/s00431-019-03318-7DOI Listing
January 2019
8 Reads

Pediatric neck masses: how clinical and radiological features can drive diagnosis.

Eur J Pediatr 2019 Jan 14. Epub 2019 Jan 14.

Pediatric Otorhinolaryngology, Department of Pediatrics, Ospedale Infantile Regina Margherita, Piazza Polonia 94, 10126, Turin, Italy.

Pediatric neck masses are a common occurrence and often represent a diagnostic challenge. The primary aim of this retrospective study was to evaluate the clinical and radiological features of neck masses in children and how they can drive diagnosis. The secondary aim was to create a diagnostic algorithm based on clinical features. Read More

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http://dx.doi.org/10.1007/s00431-018-3305-9DOI Listing
January 2019
1 Read

Human parechovirus meningitis and gross-motor neurodevelopment in young children.

Eur J Pediatr 2019 Jan 14. Epub 2019 Jan 14.

Department of Pediatrics, Elisabeth-Tweesteden Hospital, Hilvarenbeekseweg 60, 5022 LC, Tilburg, the Netherlands.

This multicenter prospective cohort study describes the impact of human parechovirus meningitis on gross-motor neurodevelopment of young children. Gross-motor function was measured using Alberta Infant Motor Scale. Of a total of 38 eligible children < 10 months of age at onset, nine cases had clinical evidence of meningitis and polymerase chain reaction positive for human parechovirus in cerebrospinal fluid; 11 had no meningitis and polymerase chain reaction positive for human parechovirus in nasopharyngeal aspirate, blood, urine, or feces; and in 18, no pathogen was identified (reference group). Read More

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http://dx.doi.org/10.1007/s00431-019-03319-6DOI Listing
January 2019

RSV hospitalization in infancy increases the risk of current wheeze at age 6 in late preterm born children without atopic predisposition.

Eur J Pediatr 2019 Jan 12. Epub 2019 Jan 12.

Department of Pediatric Infectious Diseases and Immunology, Wilhelmina Children's Hospital University Medical Center Utrecht, P.O. Box 85090, 3508 AB, Utrecht, The Netherlands.

Severe respiratory syncytial virus (RSV) infection during infancy is associated with ongoing respiratory morbidity. In a large birth cohort of 2210 healthy preterm infants born at 32-35 weeks of gestation, we aimed to determine the role of atopy in the link between RSV hospitalization and current wheeze at age 6. We defined current wheeze as parent-reported wheeze or the use of respiratory medication in the past 12 months. Read More

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http://dx.doi.org/10.1007/s00431-018-03309-0DOI Listing
January 2019

Psychogenic movement disorders in children and adolescents: an update.

Authors:
Susan R Harris

Eur J Pediatr 2019 Jan 11. Epub 2019 Jan 11.

Department of Physical Therapy, Faculty of Medicine, University of British Columbia, 212 - 2177 Wesbrook Mall, Vancouver, British Columbia, V6T 1Z3, Canada.

This short communication provides an update on childhood psychogenic movement disorders (PMD), focusing on descriptive studies and case reports from 2008 to 2018. Known also as functional movement/motor disorders, PMD diagnoses are relatively common in adults but less so in children. In group studies over the past decade, sample prevalence of childhood PMD ranged from 2. Read More

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http://dx.doi.org/10.1007/s00431-019-03317-8DOI Listing
January 2019
3 Reads

Apgar score and long-term respiratory morbidity of the offspring: a population-based cohort study with up to 18 years of follow-up.

Eur J Pediatr 2019 Jan 9. Epub 2019 Jan 9.

Department of Obstetrics and Gynecology, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

The objective of this study is to investigate whether a significant association exists between low 5-min Apgar scores (< 7) and respiratory morbidity of the offspring. A population-based cohort analysis was performed comparing subtypes of respiratory morbidity leading to hospitalizations among children (up to age 18 years) stratified by their 5 min Apgar scores. Data were collected from two databases of a regional tertiary center. Read More

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http://dx.doi.org/10.1007/s00431-018-03311-6DOI Listing
January 2019
1.983 Impact Factor

Follow-up of fatty acid β-oxidation disorders in expanded newborn screening era.

Eur J Pediatr 2019 Jan 7. Epub 2019 Jan 7.

Centro de Referência de Doenças Hereditárias do Metabolismo, Departamento de Pediatria Médica, Hospital de Santa Maria - CHULN, Av. Prof. Egas Moniz, 1649-035, Lisbon, Portugal.

Fatty acid β-oxidation (FAO) disorders have a wide variety of symptoms, not usually evident between episodes of acute decompensations. Cardiac involvement is frequent, and severe ventricular arrhythmias are suspected of causing sudden death. Expanded newborn screening (ENS) for these disorders, hopefully, contribute to prevent potentially acute life-threatening events. Read More

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http://link.springer.com/10.1007/s00431-018-03315-2
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http://dx.doi.org/10.1007/s00431-018-03315-2DOI Listing
January 2019
7 Reads

Introduction of fish and other foods during infancy and risk of asthma in the All Babies In Southeast Sweden cohort study.

Eur J Pediatr 2019 Jan 7. Epub 2019 Jan 7.

Division of Pediatrics, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.

The etiology of asthma includes lifestyle factors. Breastfeeding and introduction of complementary foods have been suggested to affect asthma risk, but the scientific foundation is not solid. Children from the birth cohort All Babies In Southeast Sweden study were included (n = 9727). Read More

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http://dx.doi.org/10.1007/s00431-018-03312-5DOI Listing
January 2019

Correction to: Maternal smoking during pregnancy and risk of cryptorchidism: a systematic review and meta-analysis.

Eur J Pediatr 2019 Jan 8. Epub 2019 Jan 8.

Department of Urology, Children's Hospital of Chongqing Medical University, Room 806, Kejiao Building (No. 6 Building), No. 136, 2nd Zhongshan Road, Yuzhong District, Chongqing City, 400014, China.

The publisher regrets that the original version of this article contained an error. Table 1 was shown in the wrong version, thus corrected table is shown in this article. The original article has been corrected. Read More

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http://link.springer.com/10.1007/s00431-018-3303-y
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http://dx.doi.org/10.1007/s00431-018-3303-yDOI Listing
January 2019
6 Reads
1.983 Impact Factor

Letter to the Editor on the original article "Ultrasound-guided peripheral intravenous access placement for children in the emergency department" by "Takehito Otani".

Eur J Pediatr 2019 Jan 5. Epub 2019 Jan 5.

Department of Anesthesiology, Pain Medicine and Intensive Care, Catharina Hospital, Eindhoven, The Netherlands.

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http://dx.doi.org/10.1007/s00431-018-03316-1DOI Listing
January 2019

New therapies for acute RSV infections: where are we?

Eur J Pediatr 2019 Feb 4;178(2):131-138. Epub 2019 Jan 4.

Department of Paediatric Pulmonology, University Hospital Leuven, University of Leuven, Herestraat 49, B-3000, Leuven, Belgium.

Respiratory syncytial virus (RSV) infection is one of the main causes of infant hospitalization and mortality. The single-stranded RNA virus codes for 11 proteins of which the F protein, a surface epitope responsible for RSV fusion, is the most targeted for developing antiviral medicines and vaccines. The peak of symptoms occurs around day 4 to 6 of illness and the airway obstruction is merely caused by the host immune inflammatory response. Read More

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http://dx.doi.org/10.1007/s00431-018-03310-7DOI Listing
February 2019
6 Reads

Respiratory syncytial virus prophylaxis in infants with congenital airway anomalies compared to standard indications and complex medical disorders.

Eur J Pediatr 2019 Jan 4. Epub 2019 Jan 4.

Medical Outcomes and Research in Economics (MORE®) Research Group, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.

An observational study was conducted of children < 2 years who received ≥ 1 dose of palivizumab in 32 Canadian institutions from 2005 to 2017. We compared respiratory illness (RIH) and respiratory syncytial virus-related hospitalization (RSVH) hazards in children with a congenital airway anomaly (CAA) versus those prophylaxed for standard indications (SI) and serious medical disorders (SMD). Data were assembled on neonatal course, demographics, palivizumab utilization and adherence, and respiratory illness events, and analyzed using ANOVA, chi-square tests and Cox proportional hazards. Read More

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http://link.springer.com/10.1007/s00431-018-03308-1
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http://dx.doi.org/10.1007/s00431-018-03308-1DOI Listing
January 2019
4 Reads

Quality of life of the family of children with asthma is not related to asthma severity.

Eur J Pediatr 2019 Jan 4. Epub 2019 Jan 4.

Department of Public Health, Institute of Health Sciences, Faculty of Medicine, Vilnius University, Vilnius, M.K Ciurlionio str. 21, 03101, Vilnius, Lithuania.

The quality of life for the family is an important outcome of childhood asthma. The aim of the study was to describe the quality of life in families who have a child with asthma. The Pediatric Quality of Life Inventory Family Impact Module was completed by the parents of 527 children with asthma. Read More

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http://dx.doi.org/10.1007/s00431-018-3306-8DOI Listing
January 2019

Urine flow cytometry is an adequate screening tool for urinary tract infections in children.

Eur J Pediatr 2018 Dec 19. Epub 2018 Dec 19.

Pediatrician, Máxima Medical Center, Postbox 7777, 5500, MB, Veldhoven, The Netherlands.

Diagnosing a urinary tract infection in children is often difficult due to non-specific symptoms and requires invasive and time-consuming procedures. Flow cytometry is a new and rapid method of analyzing urine to confirm or exclude UTIs. We have investigated the sensitivity and specificity of urine flow cytometry (Sysmex UF1000i) compared to conventional diagnostic techniques in a prospective study from January 1, 2014 until January 1, 2015. Read More

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http://link.springer.com/10.1007/s00431-018-3307-7
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http://dx.doi.org/10.1007/s00431-018-3307-7DOI Listing
December 2018
9 Reads

Epidemiology of gastrostomy insertion for children and adolescents with intellectual disability.

Eur J Pediatr 2018 Dec 15. Epub 2018 Dec 15.

Telethon Kids Institute, Centre for Child Health Research, The University of Western Australia, PO Box 855, West Perth, Western Australia, 6872, Australia.

The largest group of recipients of pediatric gastrostomy have neurological impairment with intellectual disability (ID). This study investigated trends in first gastrostomy insertion according to markers of disadvantage and ID etiology. Linked administrative and health data collected over a 32-year study period (1983-2014) for children with ID born between 1983 and 2009 in Western Australia were examined. Read More

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http://link.springer.com/10.1007/s00431-018-3304-x
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http://dx.doi.org/10.1007/s00431-018-3304-xDOI Listing
December 2018
5 Reads

A review of filamin A mutations and associated interstitial lung disease.

Eur J Pediatr 2019 Feb 13;178(2):121-129. Epub 2018 Dec 13.

Clinical Genetics Department, Our Lady's Children's Hospital, Dublin, Ireland.

The filamin A gene (FLNA) on Xq28 encodes the filamin A protein. Mutation in FLNA causes a wide spectrum of disease including skeletal dysplasia, neuronal migration abnormality, cardiovascular malformation, intellectual disability and intestinal obstruction. Recently, childhood-onset interstitial lung disease associated with a range of FLNA mutations has been recognised and reported. Read More

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http://link.springer.com/10.1007/s00431-018-3301-0
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http://dx.doi.org/10.1007/s00431-018-3301-0DOI Listing
February 2019
10 Reads

Diagnosis, management, and follow-up of mitochondrial disorders in childhood: a personalized medicine in the new era of genome sequence.

Eur J Pediatr 2019 Jan 7;178(1):21-32. Epub 2018 Dec 7.

Newborn Screening, Metabolism and Genetics Unit, Human Genetics Department, National Institute of Health Dr. Ricardo Jorge, Porto, Portugal.

Primary mitochondrial disorders are highly variable in clinical presentation, biochemistry, and molecular etiology. Mitochondrial disorders can be caused by genetic defects in the mitochondrial, in nuclear genome, or in the interplay between the two genomes. Biochemical screening tests may be inconclusive or misleading since patients, with confirmed mitochondrial disorders specially in pediatric age, may exhibit normal routine biochemistry, muscle histology, or enzymatic analysis of the mitochondrial respiratory chain. Read More

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http://dx.doi.org/10.1007/s00431-018-3292-xDOI Listing
January 2019

Association between serum 25(OH)D and hematological markers of erythropoiesis: the curse of large numbers, the treachery of p value.

Eur J Pediatr 2018 Dec 5. Epub 2018 Dec 5.

Epidemiology and Statistics Office, Research Unit, Centro Hospitalar de Lisboa Central, Lisbon, Portugal.

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http://dx.doi.org/10.1007/s00431-018-3296-6DOI Listing
December 2018
1 Read

Growth of children with biliary atresia living with native livers: impact of corticoid therapy after portoenterostomy.

Eur J Pediatr 2018 Dec 5. Epub 2018 Dec 5.

Pediatric Liver and Gut Research Group, Children's Hospital, Helsinki University Hospital, Helsinki, Finland.

We addressed growth of biliary atresia (BA) patients living with native livers between ages 0-6 and effects of post-surgical corticosteroid treatment on growth. Growth charts of 28 BA patients born in Finland between 1987 and 2017 were retrospectively evaluated. Dosage and length of corticosteroid treatment and hydrocortisone substitution were reviewed. Read More

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http://dx.doi.org/10.1007/s00431-018-3302-zDOI Listing
December 2018
2 Reads

Nutritional management of young infants presenting with acute bronchiolitis in Belgium, France and Switzerland: survey of current practices and documentary search of national guidelines worldwide.

Eur J Pediatr 2018 Dec 1. Epub 2018 Dec 1.

Paediatric Intensive Care, Hôpital Femme Mère Enfant, Nantes, France.

Feeding difficulties are common in young infants presenting with acute bronchiolitis, but limited data is available to guide clinicians adapting nutritional management. We aimed to assess paediatricians' nutritional practices among Western Europe French speaking countries. A survey was disseminated to describe advice given to parents for at home nutritional support, in hospital nutritional management, and preferred methods for enteral nutrition and for intravenous fluid management. Read More

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http://link.springer.com/10.1007/s00431-018-3300-1
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http://dx.doi.org/10.1007/s00431-018-3300-1DOI Listing
December 2018
11 Reads

Antibiotics for urethral catheterization in children undergoing cystography: retrospective evaluation of a single-center cohort of pediatric non-toilet-trained patients.

Eur J Pediatr 2018 Dec 1. Epub 2018 Dec 1.

Department of Woman, Child and of General and Specialized Surgery, Università degli Studi della Campania "Luigi Vanvitelli", Via Luigi De Crecchio 2, 80138, Naples, Italy.

Antibiotics are often used to prevent post-catheterization urinary tract infections (UTIs) in patients undergoing cystography. However, there is no universally accepted protocol and the literature data are conflicting. We aimed to determine prevalence and risk factors of post-cystography UTIs in non-toilet-trained children. Read More

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http://dx.doi.org/10.1007/s00431-018-3288-6DOI Listing
December 2018
3 Reads

Inability of Asian risk scoring systems to predict intravenous immunoglobulin resistance and coronary lesions in Kawasaki disease in an Italian cohort.

Eur J Pediatr 2018 Nov 29. Epub 2018 Nov 29.

Department of Pediatrics, S.Orsola-Malpighi Hospital, University of Bologna, Via Massarenti 9, 40138, Bologna, Italy.

Since resistance to intravenous immunoglobulin (IVIG) is associated with coronary lesions (CALs) in Kawasaki disease (KD), it is crucial to identify patients at risk to protect them from coronary involvement. The available risk scores to predict IVIG resistance were developed in Asian populations in whom their effectiveness has been proven, but data on non-Asian children are limited. The aim of this study is to evaluate the ability of the Kobayashi, Egami, and Formosa risk scores to predict IVIG resistance and CALs in Italian patients with KD. Read More

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http://dx.doi.org/10.1007/s00431-018-3297-5DOI Listing
November 2018
7 Reads

Osteoporosis-pseudoglioma syndrome: clinical, genetic, and treatment-response study of 10 new cases in Greece.

Eur J Pediatr 2018 Nov 29. Epub 2018 Nov 29.

Third Department of Pediatrics, National and Kapodistrian University of Athens, "Attikon" University General Hospital, Athens, Greece.

Osteoporosis-pseudoglioma syndrome (OPPG) is a rare autosomal-recessive disorder, characterized by severe osteoporosis and early-onset blindness. Loss of function mutations in the gene encoding low-density lipoprotein receptor-related protein 5 (LRP5) have been established as the genetic defect of the disease. We report the clinical and genetic evaluation of ten OPPG cases in eight related nuclear families and their close relatives. Read More

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http://dx.doi.org/10.1007/s00431-018-3299-3DOI Listing
November 2018

Refeeding in anorexia nervosa.

Eur J Pediatr 2018 Nov 27. Epub 2018 Nov 27.

Assistance Publique-Hôpitaux de Paris, Service d'Endocrinologie Diabétologie Pédiatrique, Centre de Référence des Maladies Endocriniennes de la Croissance et du Développement, Hôpital Robert Debré, Paris, France.

Refeeding in anorexia nervosa is a collaborative enterprise involving multidisciplinary care plans, but clinicians currently lack guidance, as treatment guidelines are based largely on clinical confidence rather than more robust evidence. It seems crucial to identify reproducible approaches to refeeding that simultaneously maximize weight recovery and minimize the associated risks, in addition to improving long-term weight and cognitive and behavioral recovery and reducing relapse rates. We discuss here various approaches to refeeding, including, among others, where, by which route, how rapidly patients are best refed, and ways of choosing between them, taking into account the precautions or the potential effects of medication or of psychological care, to define better care plans for use in clinical practice. Read More

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http://dx.doi.org/10.1007/s00431-018-3295-7DOI Listing
November 2018
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Reply to: "Nasal injury and comfort with jet versus bubble continuous positive airway pressure delivery systems in preterm infants with respiratory distress".

Eur J Pediatr 2018 Nov 23. Epub 2018 Nov 23.

Division of Plastic and Reconstructive Surgery, Department of Emergency and Organ Transplantation, University of Bari, 11, Piazza Giulio Cesare, 70124, Bari, Italy.

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http://dx.doi.org/10.1007/s00431-018-3298-4DOI Listing
November 2018

Association between exposure to macrolides and the development of infantile hypertrophic pyloric stenosis: a systematic review and meta-analysis.

Eur J Pediatr 2018 Nov 23. Epub 2018 Nov 23.

Evidence Based Medicine Research Group & Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City, Vietnam.

Macrolides are bacteriostatic antibiotics with a broad spectrum of activity against Gram-positive bacteria. The aim of this study was to systematically review and meta-analyze the association between infantile hypertrophic pyloric stenosis (IHPS) and macrolides. Nine databases were searched systematically for studies with information on the association between macrolides and IHPS. Read More

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http://link.springer.com/10.1007/s00431-018-3287-7
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http://dx.doi.org/10.1007/s00431-018-3287-7DOI Listing
November 2018
5 Reads

The association between psychological and social factors and spinal pain in adolescents.

Eur J Pediatr 2018 Nov 21. Epub 2018 Nov 21.

Department of Sports Science and Clinical Biomechanics, Clinical Biomechanics, University of Southern Denmark, Campusvej 55, 5230, Odense, Denmark.

Spinal pain, back pain, and/or neck pain begins early in life and is strongly associated with spinal pain in adulthood. Understanding the relationship between psychological and social factors and adolescent spinal pain may be important in both the prevention and treatment of spinal pain in this age group. We aimed to determine if psychological and social factors were associated with spinal pain in a cross-sectional study of a school-based cohort of 1279 Danish adolescents aged 11-13, who were categorized into "any" and "substantial" spinal pain. Read More

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http://dx.doi.org/10.1007/s00431-018-3291-yDOI Listing
November 2018
7 Reads

Maternal smoking during pregnancy and risk of cryptorchidism: a systematic review and meta-analysis.

Eur J Pediatr 2018 Nov 21. Epub 2018 Nov 21.

Department of Urology, Children's Hospital of Chongqing Medical University, Room 806, Kejiao Building (No. 6 Building), No. 136, 2nd Zhongshan Road, Yuzhong District, Chongqing City, 400014, China.

The risk factors for undescended testes in male infants and the underlying pathogenesis still remain unclear. The aim of this study is to identify the relationship between maternal smoking during pregnancy and risk of cryptorchidism. A systematic review was conducted using appropriate search terms to identify articles pertaining to maternal smoking during pregnancy and risk of cryptorchidism. Read More

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http://dx.doi.org/10.1007/s00431-018-3293-9DOI Listing
November 2018
12 Reads
1.983 Impact Factor

Incident reports versus direct observation to identify medication errors and risk factors in hospitalised newborns.

Eur J Pediatr 2019 Feb 21;178(2):259-266. Epub 2018 Nov 21.

Clinic of Neonatology, Lausanne University Hospital, Lausanne, Switzerland.

Newborns are often exposed to medication errors in hospitals. Identification and understanding the causes and risk factors associated with medication errors will help to improve the effectiveness of medication. We sought to compare voluntary incident reports and direct observation in the identification of medication errors. Read More

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http://link.springer.com/10.1007/s00431-018-3294-8
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http://dx.doi.org/10.1007/s00431-018-3294-8DOI Listing
February 2019
4 Reads

Injection site reactions after long-term subcutaneous delivery of drisapersen: a retrospective study.

Eur J Pediatr 2019 Feb 17;178(2):253-258. Epub 2018 Nov 17.

Department of Dermatology, UZ Leuven Campus Gasthuisberg, Herestraat 49, 3000, Leuven, Belgium.

A retrospective study in which we reviewed the hospital files of a subset of 7 patients with Duchenne muscular dystrophy participating in the open-label phase I/II PRO051-02 study in Leuven. The objective of this study was to describe in detail the injection site reactions in these children treated with drisapersen (PRO-051), a 2'-O-methyl phosphorothioate RNA antisense oligonucleotide, that induces exon 51 skipping in Duchenne muscular dystrophy. Antisense oligonucleotides, restoring the reading frame by skipping of exons, have become a potential treatment of Duchenne muscular dystrophy and other monogenetic diseases. Read More

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http://dx.doi.org/10.1007/s00431-018-3272-1DOI Listing
February 2019
1 Read

The effect of repeated methotrexate injections on the quality of life of children with rheumatic diseases.

Eur J Pediatr 2019 Jan 17;178(1):17-20. Epub 2018 Nov 17.

Department of Pediatric Rheumatology Willem-Alexander Children's Hospital, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands.

In clinical practice, the burden of repeated injections in children with rheumatic disease receiving disease-modifying anti-rheumatic drugs is significant. To investigate the nature and extent of impact on the quality of life after repeated injections, we conducted a literature review. Two relevant papers were identified, both about children with juvenile idiopathic arthritis (JIA) being administered methotrexate. Read More

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http://link.springer.com/10.1007/s00431-018-3286-8
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http://dx.doi.org/10.1007/s00431-018-3286-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311192PMC
January 2019
6 Reads

Efficacy of Lactobacillus-supplemented triple therapy for Helicobacter pylori infection in children: a meta-analysis of randomized controlled trials.

Eur J Pediatr 2019 Jan 16;178(1):7-16. Epub 2018 Nov 16.

Department of Gastroenterology, Ministry of Eduaction Key Laboratory of Child Development and Disorders, Key Laboratory of Pediatrics in Chongqing, Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Children's Hospital of Chongqing Medical University, No.136, Zhongshan 2nd Road, Yuzhong District, Chongqing, 400014, China.

Therapy-related side effects and severe antimicrobial resistance still remain an obstacle to Helicobacter pylori eradication. This meta-analysis aimed to investigate the efficacy of Lactobacillus-supplemented triple therapy on H. pylori eradication rates and therapy-related side effects in children. Read More

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http://link.springer.com/10.1007/s00431-018-3282-z
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http://dx.doi.org/10.1007/s00431-018-3282-zDOI Listing
January 2019
15 Reads