1,883 results match your criteria European Journal of Paediatric Neurology[Journal]


Modalities of reading acquisition in three siblings with infantile-onset saccade initiation delay (Cogan congenital ocular motor apraxia): A longitudinal study.

Eur J Paediatr Neurol 2019 Feb 8. Epub 2019 Feb 8.

Pediatric Neurology Unit, Pediatric Subspecialties Service, Children's Hospital of Geneva, Switzerland.

This study aims to ascertain the impact of congenital ocular motor apraxia (COMA), alternatively called infantile-onset saccade initiation delay (ISID), on reading acquisition. More specifically, the consequence of defective initiation of horizontal saccades during reading acquisition was investigated. Three siblings (A: male, 11y3m at the first time-point of testing (i. Read More

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http://dx.doi.org/10.1016/j.ejpn.2019.01.008DOI Listing
February 2019

Cerebral palsy among children of immigrants in Denmark and the role of socioeconomic status.

Eur J Paediatr Neurol 2019 Feb 4. Epub 2019 Feb 4.

Department of Public Health at University of Copenhagen, Oesterfarimagsgade 5, Postboks 2099, 1014 Copenhagen, Denmark.

Background: Children of immigrants in Denmark have excess risk for some of the most well-established risk factors for cerebral palsy (CP).

Objectives: To study differences in risk of CP between children of immigrants and children of Danish-born mothers, and explore whether socioeconomic status drives any potential association.

Methods: A register-based cohort study including 1,274,616 children born in Denmark between 1981 and 2007. Read More

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http://dx.doi.org/10.1016/j.ejpn.2019.01.007DOI Listing
February 2019

Punctate white-matter lesions in the full-term newborn: Underlying aetiology and outcome.

Eur J Paediatr Neurol 2019 Jan 26. Epub 2019 Jan 26.

Department of Neonatology, Wilhelmina Children's Hospital, Utrecht, University Medical Center Utrecht, Utrecht University, the Netherlands.

Background: Punctate white matter lesions (PWMLs) are small focal patches of increased signal intensity (SI) on T1- and decreased SI on T2-weighted magnetic resonance imaging (MRI). To date, there have been few reports of PWMLs in term born infants.

Objective: To identify associated diagnoses and factors predictive of clinical outcome in (near) term infants with PWMLs. Read More

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http://dx.doi.org/10.1016/j.ejpn.2019.01.005DOI Listing
January 2019
1 Read

Predictive factors and prognostic value for status epilepticus in newborns.

Eur J Paediatr Neurol 2019 Jan 29. Epub 2019 Jan 29.

Epileptology, Sleep Disorders and Functional Pediatric Neurology, Member of ERN-EpiCARE; HFME, Hospices Civils de Lyon, 59 Boulevard Pinel, Bron, France.

Objectives: To evaluate the predictive factors for status epilepticus (SE) in neonates and prognostic factors for patient outcomes in newborns suffering either isolated seizures or SE.

Methods: A retrospective single-center study from January 2010 to December 2014, included 91 newborns who had neonatal seizures. Among them, 50 newborns experienced SE and 41 newborns presented isolated seizures only. Read More

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http://dx.doi.org/10.1016/j.ejpn.2019.01.006DOI Listing
January 2019
2 Reads

Risk of Developmental Coordination Disorder in Italian very preterm children at school age compared to general population controls.

Eur J Paediatr Neurol 2019 Jan 11. Epub 2019 Jan 11.

Clinical Care and Management Innovation Research Area, Bambino Gesù Children's Hospital, IRCCS, Viale Ferdinando Baldelli 41, 00146, Rome, Italy. Electronic address:

Background: Developmental Coordination Disorder (DCD) is a neurodevelopmental disorder that involves difficulties in goal-directed motor coordination, with ineffective control of fine and gross motor movements in the absence of sensory impairment or neurological condition. DCD is frequently reported in children born very preterm (VP) who survive without CP.

Aims: To measure the risk of DCD at school age in a large area-based cohort of VP children and general population controls, adjusting for gender, birth weight by gestational age and age at assessment. Read More

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http://dx.doi.org/10.1016/j.ejpn.2019.01.002DOI Listing
January 2019

A population-based and case-controlled study of children and adolescents with narcolepsy: Health-related quality of life, adaptive behavior and parental stress.

Eur J Paediatr Neurol 2019 Jan 19. Epub 2019 Jan 19.

Department of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.

Objective: To investigate health-related quality of life (HrQoL) and adaptive behavior in young people with narcolepsy and stress among their parents.

Methods: In a cross-sectional exploratory quantitative study design, 37 young people with narcolepsy (8-20 years of age) and their parents were recruited. Thirty-one had post-H1N1 vaccination-related narcolepsy (PHV) and six had narcolepsy not related to PHV (nPHV). Read More

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http://dx.doi.org/10.1016/j.ejpn.2019.01.004DOI Listing
January 2019
2 Reads

Clinical deterioration despite syringomyelia resolution after successful foramen magnum decompression for Chiari malformation - Case series.

Eur J Paediatr Neurol 2019 Jan 14. Epub 2019 Jan 14.

Department of Paediatric Neurosciences, Royal Hospital for Sick Children, Edinburgh, UK.

Introduction: Neurosurgical treatment is recommended for symptomatic syringomyelia and the post-operative radiological resolution of the syringomyelia is associated with an improvement or at least stability of the patient's pre-operative symptoms.

Methods: We reviewed syringomyelia treatment in our centre over the last five years for clinical outcome, surgical complications, post operative MRI and long term symptom resolution.

Results: 50 cases of symptomatic syringomyelia underwent foramen magnum decompression and expansile watertight duroplasty. Read More

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http://dx.doi.org/10.1016/j.ejpn.2019.01.003DOI Listing
January 2019

Acute flaccid myelitis caused by enterovirus D68: Case definitions for use in clinical practice.

Eur J Paediatr Neurol 2019 Jan 11. Epub 2019 Jan 11.

Paediatric Neurosciences, Royal Hospital for Sick Children, Edinburgh, UK; Child Life and Health, University of Edinburgh, Edinburgh, UK.

Acute flaccid myelitis (AFM) was increasingly detected in recent years, coinciding with upsurges of enterovirus D68 (EV-D68) infections. We reviewed the evidence for a causal relationship between both. Based on reported cases, we provide case definitions for AFM caused by EV-D68 infections to enable a standard procedure for affected patients. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10903798183028
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http://dx.doi.org/10.1016/j.ejpn.2019.01.001DOI Listing
January 2019
5 Reads

Editorial relating to paper by Schoonjans et al. EJPN 2019; A good night's sleep in Dravet syndrome - an unmet need.

Eur J Paediatr Neurol 2019 01;23(1)

Paediatric Neurosciences Research Group, Royal Hospital for Children, Glasgow, G51 4TF, UK; College of Medical, Veterinary & Life Sciences, University of Glasgow, G12 8QQ, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ejpn.2018.12.009DOI Listing
January 2019
1 Read

Physical activity after mild traumatic brain injury: What are the relationships with fatigue and sleep quality? Is physical activity a key to prevention of post-concussive symptoms?

Eur J Paediatr Neurol 2019 01;23(1):4-5

Dept of Paediatric Neurology, Erasmus University, Sophia Children's Hospital, Rotterdam, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.ejpn.2018.12.008DOI Listing
January 2019
2 Reads

Editorial note.

Authors:
Sameer M Zuberi

Eur J Paediatr Neurol 2019 01;23(1)

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http://dx.doi.org/10.1016/j.ejpn.2018.12.007DOI Listing
January 2019
1 Read

Challenges in evaluating the oculomotor function in individuals with Rett syndrome using electronystagmography.

Eur J Paediatr Neurol 2018 Dec 18. Epub 2018 Dec 18.

Rett Expertise Center - Governor Kremers Center, Maastricht University Medical Center, Maastricht, the Netherlands; Division of Balance Disorders, Department of Otorhinolaryngology and Head and Neck Surgery, Maastricht University Medical Center, Maastricht, Netherlands; Faculty of Physics, Tomsk State University, Tomsk, Russia. Electronic address:

Background: Rett syndrome (RTT) is a neurological disorder characterized by a broad spectrum of symptoms. Communication is a major area of difficulty. Use of eye tracking technology offers a potentially effective method of communication when underpinned by intact oculomotor function. Read More

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http://dx.doi.org/10.1016/j.ejpn.2018.12.003DOI Listing
December 2018
7 Reads

Characteristic clinical and ultrastructural findings in nesprinopathies.

Eur J Paediatr Neurol 2018 Dec 29. Epub 2018 Dec 29.

Department of Pediatric Neurology, Developmental Neurology and Social Pediatrics, University of Essen, Germany.

Aims: To define the neurological and neuropathological alterations caused by SYNE1 mutations.

Methods: We describe 5 patients (3 males, 2 females; age 3-24 years) from 3 families. The diagnostic work-up included three muscle biopsies and two nerve biopsies in three of the cases. Read More

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http://dx.doi.org/10.1016/j.ejpn.2018.12.011DOI Listing
December 2018
3 Reads

Re-emergence of SSPE: Consequence of the decline of adherence to vaccination programmes?

Eur J Paediatr Neurol 2018 Dec 30. Epub 2018 Dec 30.

Department of Biomedical and Clinical Sciences, L. Sacco, University of Milan, Italy; Department of Child Neurology, V. Buzzi Children's Hospital, University of Milan, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ejpn.2018.12.010DOI Listing
December 2018
1 Read

SLC2A1 mutations are a rare cause of pediatric-onset hereditary spastic paraplegia.

Eur J Paediatr Neurol 2018 Dec 18. Epub 2018 Dec 18.

Unit of Neuromuscolar and Neurodegenerative Diseases, Department of Neurosciences, Bambino Gesù Research Hospital, Rome, Italy.

SLC2A1 mutations cause glucose transporter type 1 deficiency syndrome, whose phenotypic spectrum is a continuum, ranging from classic to variant phenotypes, the latter accounting for about 10% of cases. Very few SLC2A1-mutated patients with a spastic paraplegia phenotype have been reported so far, and they are associated with paroxysmal choreo-athetosis (i.e. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10903798183042
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http://dx.doi.org/10.1016/j.ejpn.2018.12.004DOI Listing
December 2018
5 Reads

Motor function in survivors of pediatric acute lymphoblastic leukemia treated with chemotherapy-only.

Eur J Paediatr Neurol 2018 Dec 17. Epub 2018 Dec 17.

Department of Pediatric Oncology/Hematology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Germany. Electronic address:

Background: Up to 43% of survivors of pediatric acute lymphoblastic leukemia (ALL) may exhibit fine-motor problems. Information on manual dexterity in this cohort is still limited.

Objectives: We tested survivors of childhood ALL treated with chemotherapy-only for fine-motor function in terms of drawing and handwriting abilities using a Digitizing Tablet (DT) with three tasks for drawing and handwriting of varying complexity, for ataxia using the International Cooperative Ataxia Rating Scale (ICARS), and for tremor and hand-eye coordination using the Nine Hole Steadiness Tester (NHST). Read More

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http://dx.doi.org/10.1016/j.ejpn.2018.12.005DOI Listing
December 2018
1 Read

Epilepsy in children with type 1 diabetes mellitus: Pathophysiological basis and clinical hallmarks.

Eur J Paediatr Neurol 2018 Dec 21. Epub 2018 Dec 21.

Pediatric Diabetology Unit, Department of Maternal and Infantile Health, Sapienza University of Rome, Italy.

We provide an overview on the current knowledge about the association between epilepsy and type 1 diabetes mellitus (T1DM). People with T1DM have a 2-6-fold higher risk of epilepsy than the general population. The onset of T1DM anticipates the onset of epilepsy by a mean period between 1,5 and 2,8 years. Read More

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http://dx.doi.org/10.1016/j.ejpn.2018.12.006DOI Listing
December 2018
1 Read

Cognitive-behavioural treatment of functional neurological symptoms (conversion disorder) in children and adolescents: A case series.

Eur J Paediatr Neurol 2018 Dec 13. Epub 2018 Dec 13.

Great Ormond Street Hospital for Children NHS Trust, Great Ormond Street, London, WC1N 3JH, UK; UCL Great Ormond Street Institute of Child Health (ICH), 30 Guilford Street, London, WC1N 1EH, UK. Electronic address:

Aim: To describe a cognitive-behavioural treatment and clinical outcomes in a series of children with functional neurological symptoms (FNS).

Method: Thirty-six children with FNS were assessed and of these twenty-two (13 male, 9 female) with a mean age 14.5 years (SD = 2. Read More

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http://dx.doi.org/10.1016/j.ejpn.2018.12.002DOI Listing
December 2018
2 Reads

Functional outcome after traumatic cervical spinal cord injury is superior in adolescents compared to adults.

Eur J Paediatr Neurol 2018 Dec 11. Epub 2018 Dec 11.

Department of Pediatric Traumatology, Trauma Center, Prof.-Küntscher-Str. 8, 82418, Murnau, Germany.

Objective: Determining differences in neurological and functional outcome between adolescents and adults after acute traumatic spinal cord injury (SCI).

Design: Retrospective, multi-center case-control study.

Methods: 100 cases of patients under 18 years at accident with acute traumatic cervical SCI admitted to SCI centers participating in the European Multi-center study about SCI (EMSCI) between January 2005 and April 2016 were reviewed. Read More

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http://dx.doi.org/10.1016/j.ejpn.2018.12.001DOI Listing
December 2018
1 Read

Fetal ventriculomegaly: What we have and what is still missing.

Eur J Paediatr Neurol 2018 11;22(6):898-899

1st Department of Pediatrics, "Hippokratio" General Hospital, Aristotle University, Thessaloniki, Greece.

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http://dx.doi.org/10.1016/j.ejpn.2018.11.005DOI Listing
November 2018
1 Read

Fetal Neurology.

Eur J Paediatr Neurol 2018 11;22(6):895-897

Fetal Neurology Clinic, Obstetrics-Gynecology Ultrasound Unit, and Pediatric Neurology Unit, Wolfson Medical Center, Holon, Tel-Aviv, Israel; Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.

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https://linkinghub.elsevier.com/retrieve/pii/S10903798183050
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http://dx.doi.org/10.1016/j.ejpn.2018.11.004DOI Listing
November 2018
6 Reads

Physical activity after mild traumatic brain injury: What are the relationships with fatigue and sleep quality?

Eur J Paediatr Neurol 2019 Jan 14;23(1):53-60. Epub 2018 Nov 14.

Sophia Rehabilitation, The Hague, The Netherlands; Leiden University Medical Centre, Department of Orthopaedics, Rehabilitation and Physical Therapy, Leiden, The Netherlands.

Objectives: To determine self-reported physical activity (PA) levels and relationships with fatigue and sleep quality in adolescents and young adults after mild traumatic brain injury (mTBI).

Setting: Follow-up 6-18 months after visiting the emergency department of one of 2 general hospitals.

Participants: Forty-nine adolescents and young adults aged 12-25 years (mean 18. Read More

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http://dx.doi.org/10.1016/j.ejpn.2018.11.002DOI Listing
January 2019
1 Read

Recurrent arterial ischemic stroke with good response to mycophenolate mofetil.

Eur J Paediatr Neurol 2019 Jan 14;23(1):222-227. Epub 2018 Nov 14.

Department of Paediatrics, Division of Paediatric Neurology, Ghent University Hospital, C. Heymanslaan 10, B-9000, Gent, Belgium. Electronic address:

Background: Arterial ischemic stroke is rare in childhood. Often, the diagnosis is made after considerable delay. A thorough workup to pinpoint the underlying etiology is necessary, as a correct diagnosis is the determining factor in treatment decision. Read More

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http://dx.doi.org/10.1016/j.ejpn.2018.11.003DOI Listing
January 2019
2 Reads

The neuroimaging mimics of abusive head trauma.

Eur J Paediatr Neurol 2019 Jan 22;23(1):19-30. Epub 2018 Nov 22.

Department of Neuroradiology, SickKids, 555 University Avenue, Toronto, Ontario, M5G 1X8, Canada.

Abusive head trauma (AHT) is a significant cause of morbidity and mortality in the paediatric population, typically in children under the age of two years. Neuroimaging plays a key role in the diagnostic work up of these patients as information regarding the mechanism of injury is often lacking and the findings on examination can be nonspecific. A number of conditions, both traumatic and atraumatic can mimic AHT based on neuroimaging features alone. Read More

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http://dx.doi.org/10.1016/j.ejpn.2018.11.006DOI Listing
January 2019
1 Read

CSF nerve growth factor (β-NGF) is increased but CSF insulin-like growth factor-(IGF-1) is normal in children with tuberous sclerosis and infantile spasms.

Eur J Paediatr Neurol 2019 Jan 14;23(1):191-196. Epub 2018 Nov 14.

School of Medicine, University of Eastern Finland, Kuopio, Finland. Electronic address:

Tuberous sclerosis is associated with epilepsy that is often refractory. We examined cerebrospinal fluid (CSF) concentrations for neurotrophins, nerve growth factor (β-NGF) and insulin-like growth factor (IGF-1) in children with infantile spasms between 1997 and 2010. We classified the patients as follows: tuberous sclerosis (n = 5), cryptogenic spasms (n = 6), postinfectious spasms (n = 5) and other symptomatic spasms (n = 22). Read More

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http://dx.doi.org/10.1016/j.ejpn.2018.11.001DOI Listing
January 2019
3 Reads

Bickerstaff Brainstem Encephalitis and overlapping Guillain-Barré syndrome in children: Report of two cases and review of the literature.

Eur J Paediatr Neurol 2019 Jan 20;23(1):43-52. Epub 2018 Nov 20.

Pediatric Clinic, Foundation IRCCS Policlinico "San Matteo", University of Pavia, Pavia, Italy.

Bickerstaff Brainstem Encephalitis (BBE) is a rare autoimmune encephalitis, characterized by acute ophthalmoplegia, ataxia and altered state of consciousness. Together with Guillan-Barrè Syndrome (GBS) and Miller-Fisher Syndrome, it forms a spectrum of post-infectious demyelinating diseases. Overlapping forms between BBE and GBS (BBE/GBS) are described in patients with lower limbs weakness and typical signs of BBE, suggesting a combined involvement of Central and Peripheral Nervous System (PNS), but only few reported cases are focused on pediatric population. Read More

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http://dx.doi.org/10.1016/j.ejpn.2018.11.008DOI Listing
January 2019
3 Reads

Efficacy and tolerability of olive oil-based ketogenic diet in children with drug-resistant epilepsy: A single center experience from Turkey.

Eur J Paediatr Neurol 2019 Jan 20;23(1):143-151. Epub 2018 Nov 20.

Dokuz Eylul University, Division of Pediatric Metabolism and Nutrition, Izmir, Turkey. Electronic address:

Purpose: Ketogenic diet (KD) is an effective non-pharmacological treatment for drug-resistant epilepsy. The aim of this study was to investigate the efficacy, tolerability and complications of olive oil-based KD in epileptic children.

Method: In this single-center, prospective study, patients were followed up at 1, 3, 6 and 12 months after KD initiation. Read More

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http://dx.doi.org/10.1016/j.ejpn.2018.11.007DOI Listing
January 2019
2 Reads

Gait in children with infantile/atypical autism: Age-dependent decrease in gait variability and associations with motor skills.

Eur J Paediatr Neurol 2019 Jan 29;23(1):117-125. Epub 2018 Sep 29.

Division of Neuropediatrics and Developmental Medicine, University Children's Hospital Basel, Spitalstrasse 33, 4056 Basel, Switzerland.

Gait and its associations with prewalking motor milestones, motor skills, and age were investigated in 32 children with infantile/atypical autism and 36 typically developing controls. Gait was assessed using GAITRite recordings of spatiotemporal and variability gait parameters. Parents reported their child's prewalking motor milestones. Read More

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http://dx.doi.org/10.1016/j.ejpn.2018.09.011DOI Listing
January 2019
9 Reads

Fetal midline anomalies: Diagnosis and counselling part 2: Septal anomalies.

Eur J Paediatr Neurol 2018 11 8;22(6):963-971. Epub 2018 Nov 8.

Womeńs Health and Perinatology Research Group, Department of Clinical Medicine, UiT-The Arctic University of Norway, Tromsø, Norway; Department of Obstetrics and Gynaecology, University Hospital of Northern Norway, Tromsø, Norway. Electronic address:

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http://dx.doi.org/10.1016/j.ejpn.2018.10.003DOI Listing
November 2018
1 Read

Fetal stroke and cerebrovascular disease: Advances in understanding from lenticulostriate and venous imaging, alloimmune thrombocytopaenia and monochorionic twins.

Eur J Paediatr Neurol 2018 Nov 11;22(6):989-1005. Epub 2018 Sep 11.

Departments of Child Health, Obstetrics and Gynaecology and Radiology, University Hospital Southampton, United Kingdom; Clinical and Experimental Sciences, University of Southampton, United Kingdom.

Fetal stroke is an important cause of cerebral palsy but is difficult to diagnose unless imaging is undertaken in pregnancies at risk because of known maternal or fetal disorders. Fetal ultrasound or magnetic resonance imaging may show haemorrhage or ischaemic lesions including multicystic encephalomalacia and focal porencephaly. Serial imaging has shown the development of malformations including schizencephaly and polymicrogyra after ischaemic and haemorrhagic stroke. Read More

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http://dx.doi.org/10.1016/j.ejpn.2018.08.008DOI Listing
November 2018
12 Reads

Obstetric brachial plexus palsy - A prospective, population-based study of incidence, recovery and long-term residual impairment at 10 to 12 years of age.

Eur J Paediatr Neurol 2019 Jan 25;23(1):87-93. Epub 2018 Jun 25.

Department of Paediatrics, Institute of Clinical Sciences at the Sahlgrenska Academy, University of Gothenburg, Sweden. Electronic address:

Aim: To assess the long-term outcome and evaluate prognostic factors in obstetric brachial plexus palsy (OBPP).

Methods: Of all 114 children with OBPP born in western Sweden in 1999-2001, 98 (61 males, 37 females) were invited to participate. A questionnaire on the symptoms of the OBPP was sent out and those with persisting symptoms were examined in terms of muscle strength, range of motion (ROM), activities of daily living (ADL), pain and sensibility at the age of 10-12 years. Read More

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http://dx.doi.org/10.1016/j.ejpn.2018.06.006DOI Listing
January 2019
13 Reads

Adolescent and parent factors related to fatigue in paediatric multiple sclerosis and chronic fatigue syndrome: A comparative study.

Eur J Paediatr Neurol 2019 Jan 2;23(1):70-80. Epub 2018 Nov 2.

Health Psychology Section, Institute of Psychiatry, Psychology & Neuroscience at King's College London, UK. Electronic address:

Background: Fatigue is a disabling, poorly understood symptom in children and adolescents with multiple sclerosis (caMS), for which effective treatments are lacking. In paediatric Chronic Fatigue Syndrome (CFS), effective psychological interventions have been developed based on psychosocial factors associated with fatigue. This study aimed to identify potentially modifiable factors of fatigue in caMS by comparing caMS, adolescents with CFS, healthy adolescents and their parents on measures of fatigue, psychosocial factors, and neurocognitive functioning. Read More

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http://dx.doi.org/10.1016/j.ejpn.2018.10.006DOI Listing
January 2019
1 Read

Two-minute versus 6-minute walk distances during 6-minute walk test in neuromuscular disease: Is the 2-minute walk test an effective alternative to a 6-minute walk test?

Eur J Paediatr Neurol 2019 Jan 23;23(1):165-170. Epub 2018 Oct 23.

Clinical Research Center, Rehabilitation Medicine Department, National Institutes of Health, Bethesda, MD, 20814, USA. Electronic address:

Functional tests such as Motor Function Measure-32 (MFM-32), supine to stand, ascend/descend stairs permit the assessment of task-specific motor function in neuromuscular disease (NMD). The 6-min walk test (6MWT), though functional, is primarily used to assess endurance and disease progression in children with neuromuscular disorders. Barriers to 6MWT administration, in this population, can include reduced attention span due to age and inability to tolerate test length due to weakness. Read More

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http://dx.doi.org/10.1016/j.ejpn.2018.10.001DOI Listing
January 2019
2 Reads

Prenatal diagnosis of brainstem anomalies.

Eur J Paediatr Neurol 2018 Nov 6;22(6):1016-1026. Epub 2018 Jul 6.

Fetal Neurology Clinic, Ultrasound in Ob-Gyn Unit, Wolfson Medical Center, Holon, Israel; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel; Pediatric Neurology Unit, Wolfson Medical Center, Holon, Israel.

Prenatal diagnosis of brainstem anomalies is important due to the usually associated neurodevelopmental impairment and genetic implications. The extreme developmental changes that the brainstem and cerebellum undergo during fetal life pose a challenge for the characterization and definition of the different malformations. The present review aims to demonstrate the normal development of the fetal brainstem and to present the main features required for diagnosis of its anomalies according to available data in the medical literature. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10903798183022
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http://dx.doi.org/10.1016/j.ejpn.2018.06.011DOI Listing
November 2018
3 Reads

Fetal midline anomalies: Diagnosis and counselling Part 1: Corpus callosum anomalies.

Eur J Paediatr Neurol 2018 Nov 21;22(6):951-962. Epub 2018 Oct 21.

Womenś Health and Perinatology Research Group, Department of Clinical Medicine, Faculty of Health Sciences, UiT-The Arctic University of Norway, Tromsø, Norway; Department of Obstetrics and Gynaecology, University Hospital of Northern Norway, Tromsø, Norway. Electronic address:

Midline anomalies encompasses a heterogeneous group of conditions caused by an abnormal process of ventral induction after the end of primary neurulation. Advances in prenatal imaging techniques have led to an increase in the detection rate of such anomalies since the first trimester of pregnancy although a significant proportion of them remain undiagnosed until birth. Ultrasound is the primary technique in detecting such anomalies while fetal magnetic resonance imaging (MRI) is commonly performed to confirm the diagnosis and detect additional anomalies, especially those involving the cortical surface of the brain, which may potentially impact post-natal outcome. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10903798183020
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http://dx.doi.org/10.1016/j.ejpn.2018.08.007DOI Listing
November 2018
17 Reads

A systematic review of comorbidity between cerebral palsy, autism spectrum disorders and Attention Deficit Hyperactivity Disorder.

Eur J Paediatr Neurol 2019 Jan 2;23(1):31-42. Epub 2018 Nov 2.

Scientific Institute I.R.C.C.S, "Eugenio Medea", "La Nostra Famiglia", Unit for Severe Disabilities in Developmental Age and Young Adults (Developmental Neurology and Neurorehabilitation), Brindisi Research Centre, Brindisi, Italy. Electronic address:

Objectives: The aim of this systematic review was to examine the incidence and prevalence of comorbidity between Cerebral Palsy (CP), Autism spectrum disorders (ASDs) and Attention-Deficit/Hyperactivity Disorder (ADHD).

Methods: We searched for articles indexed in PubMed, EBSCOhost, Scopus, Web of Science and other potentially relevant internet sources using a combination of expressions including "cerebral palsy" AND "autism" OR "ASD" OR "pervasive development disorder" AND "Attention Deficit Hyperactivity Disorder" OR "ADHD".

Results: We identified 2542 studies on CP and ASD and 998 studies on CP and ADHD. Read More

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http://dx.doi.org/10.1016/j.ejpn.2018.10.005DOI Listing
January 2019
5 Reads

Usefulness of perampanel with concomitant levetiracetam for patients with drug-resistant epilepsy.

Eur J Paediatr Neurol 2019 Jan 2;23(1):197-203. Epub 2018 Nov 2.

Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Japan.

Purpose: The purpose was to evaluate the efficacy of treatment and the occurrence of aggression-related adverse events among children receiving perampanel (PER) with concomitant levetiracetam (LEV).

Methods: Patients were selected according to the following criteria: 1) between 12 and 18 years old; 2) seizures refractory to at least 2 first-line drugs; 3) at least 4 seizures a month before PER administration; and 4) at least 12 months of follow-up. Patients were subdivided into groups with and without LEV as concomitant treatment. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10903798183030
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http://dx.doi.org/10.1016/j.ejpn.2018.10.004DOI Listing
January 2019
7 Reads

Hearing impairment and hypoxia ischaemic encephalopathy: Incidence and associated factors.

Eur J Paediatr Neurol 2019 Jan 10;23(1):81-86. Epub 2018 Oct 10.

Neonatal Department, Rotunda Hospital, Dublin 1, Ireland. Electronic address:

Objective: To establish the local incidence of hearing loss in newborns with Hypoxic Ischaemic Encephalopathy (HIE) and to identify associated risk factors.

Study Design: Retrospective Cohort Study. Neonatal Intensive Care Unit (NICU) dual stage hearing screening protocol, including automated otoacoustic emissions (AOAE) and automated auditory brainstem response (AABR) testing. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10903798183012
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http://dx.doi.org/10.1016/j.ejpn.2018.10.002DOI Listing
January 2019
14 Reads

More daytime sleepiness and worse quality of sleep in patients with Dravet Syndrome compared to other epilepsy patients.

Eur J Paediatr Neurol 2019 Jan 27;23(1):61-69. Epub 2018 Sep 27.

Department of Pediatric Neurology, Antwerp University Hospital, University of Antwerp, Belgium.

Aim: Sleep problems are often reported in patients with a Dravet Syndrome (DS). In this study we explored the sleep behavior in DS and compared the prevalence of sleep problems with other epilepsy patients.

Methods: An online questionnaire based on the 'Sleep Behavior Questionnaire by Simonds & Parraga (SQ-SP)' was distributed amongst DS parents and a control group (parents from children with epilepsy). Read More

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http://dx.doi.org/10.1016/j.ejpn.2018.09.012DOI Listing
January 2019
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Mycophenolate mofetil, azathioprine and methotrexate usage in paediatric anti-NMDAR encephalitis: A systematic literature review.

Eur J Paediatr Neurol 2019 Jan 27;23(1):7-18. Epub 2018 Sep 27.

Neuroimmunology Group, Institute for Neuroscience and Muscle Research, Kids Research Institute at the Children's Hospital at Westmead, University of Sydney, Australia. Electronic address:

Background: Available data on mycophenolate mofetil (MMF), azathioprine (AZA) and methotrexate (MTX) for paediatric-onset anti-N-methyl-d-aspartate receptor encephalitis (anti-NMDARE) is limited.

Methods: Systematic literature review on patients treated with MMF/AZA/MTX for paediatric-onset anti-NMDARE, with focus on modes of use, efficacy and safety.

Results: 87 patients were included (age at onset median 11 years, range 0. Read More

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http://dx.doi.org/10.1016/j.ejpn.2018.09.008DOI Listing
January 2019
10 Reads

CSF neopterin, a useful biomarker in children presenting with influenza associated encephalopathy?

Eur J Paediatr Neurol 2019 Jan 28;23(1):204-213. Epub 2018 Sep 28.

Sydney Children's Hospital Network (SCHN), Australia; The University of New South Wales, Australia.

Purpose: Neurological complications of influenza cause significant disease in children. Central nervous system inflammation, the presumed mechanism of influenza-associated encephalopathy, is difficult to detect. Characteristics of children presenting with severe neurological complications of influenza, and potential biomarkers of influenza-associated encephalopathy are described. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10903798183020
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http://dx.doi.org/10.1016/j.ejpn.2018.09.009DOI Listing
January 2019
4 Reads
1.934 Impact Factor

Atypical language representation is unfavorable for language abilities following childhood stroke.

Eur J Paediatr Neurol 2019 Jan 25;23(1):102-116. Epub 2018 Sep 25.

Department of Pediatrics and Adolescent Medicine, Medical University Vienna, Vienna, Austria.

Brain plasticity has often been quoted as a reason for the more favorable outcome in childhood stroke compared to adult stroke. We investigated the relationship between language abilities and language localization in childhood stroke. Seventeen children and adolescents with left- or right-sided ischemic stroke and 18 healthy controls were tested with a comprehensive neurolinguistic test battery, and the individual neural representation of language was measured with an fMRI language paradigm. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10903798183018
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http://dx.doi.org/10.1016/j.ejpn.2018.09.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339521PMC
January 2019
2 Reads

Evaluation of long-term safety, tolerability, and behavioral outcomes with adjunctive rufinamide in pediatric patients (≥1 to <4 years old) with Lennox-Gastaut syndrome: Final results from randomized study 303.

Eur J Paediatr Neurol 2019 Jan 27;23(1):126-135. Epub 2018 Sep 27.

Formerly of Eisai Neurology Business Group, Eisai Inc., 100 Tice Boulevard, Woodcliff Lake, NJ 07677, USA. Electronic address:

Objective: Evaluate the long-term safety, tolerability, and behavioral effects of adjunctive rufinamide in pediatric patients (≥1 to <4 years old) with inadequately controlled seizures associated with Lennox-Gastaut syndrome (LGS).

Methods: Study 303 (ClinicalTrials.gov identifier NCT01405053) was a multicenter, randomized, open-label, Phase III trial. Read More

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http://dx.doi.org/10.1016/j.ejpn.2018.09.010DOI Listing
January 2019
1 Read
1.934 Impact Factor

Safety, tolerability, and effectiveness of oral zonisamide therapy in comparison with intramuscular adrenocorticotropic hormone therapy in infants with West syndrome.

Eur J Paediatr Neurol 2019 Jan 22;23(1):136-142. Epub 2018 Sep 22.

Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India. Electronic address:

West syndrome is a distinct, infantile onset, epileptic encephalopathy, associated with poor neurodevelopmental outcome. The present study was designed as a randomized, open-label, pilot study to evaluate the safety, feasibility, and effectiveness of oral zonisamide therapy in comparison with adrenocorticotropic hormone therapy in infants with West syndrome. Thirty infants with West syndrome were randomized to receive treatment with either synthetic, intramuscular adrenocorticotropic hormone (30-60 IU) or oral zonisamide (4-25 mg/kg/day). Read More

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http://dx.doi.org/10.1016/j.ejpn.2018.09.006DOI Listing
January 2019
1 Read

Methylphenidate use in males with Duchenne muscular dystrophy and a comorbid attention-deficit hyperactivity disorder.

Eur J Paediatr Neurol 2019 Jan 21;23(1):152-157. Epub 2018 Sep 21.

Kempenhaeghe Centre for Neurological Learning Disabilities, Heeze, the Netherlands; Maastricht University Medical Centre, Department of Neurology, School for Mental Health and Neuroscience, Maastricht, the Netherlands; Duchenne Centre Netherlands, the Netherlands.

Attention-deficit hyperactivity disorder (ADHD) is a common comorbidity in Duchenne muscular dystrophy (DMD). Until now, treatment with methylphenidate (MPH) has never been systematically assessed and described in this population. Our aim was to evaluate the effectiveness and safety of short acting MPH for learning problems in males with DMD and ADHD. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10903798183023
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http://dx.doi.org/10.1016/j.ejpn.2018.09.005DOI Listing
January 2019
12 Reads

Increased cerebral microbleeds and cortical superficial siderosis in pediatric patients with Down syndrome.

Eur J Paediatr Neurol 2019 Jan 12;23(1):158-164. Epub 2018 Sep 12.

Department of Radiology, University Hospital, LMU Munich, Marchioninistr. 15, 81377, Munich, Germany; Department of Radiology, The Hospital for Sick Children, 555 University Ave, Toronto, ON M5G1X8, Canada.

Background: Patients with Down syndrome carry a third copy of the amyloid precursor protein gene, which is localized on chromosome 21. Consequently, these patients are prone to develop early-onset Alzheimer disease and cerebral amyloid angiopathy. Post-mortem studies suggest increased amyloid deposition to be already detectable in children with Down syndrome. Read More

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http://dx.doi.org/10.1016/j.ejpn.2018.09.004DOI Listing
January 2019
2 Reads

Diagnosis of tuberous sclerosis complex in the fetus.

Eur J Paediatr Neurol 2018 Nov 12;22(6):1027-1034. Epub 2018 Sep 12.

1st Department of Pediatrics, Developmental Center "A. Fokas", Aristotle University of Thessaloniki, "Hippokratio" General Hospital, Thessaloniki, Greece. Electronic address:

Tuberous sclerosis complex is a dominantly inherited genetic disorder of striking clinical variability. It is caused by mutations in either TSC1 or TSC2 gene, which regulate cell growth and proliferation by inhibition of mTORC1 signaling. TS is characterized by the development of benign tumors in many tissues and organs and its neurological manifestations include epilepsy, autism, cognitive and behavioral dysfunction, and giant cell tumors. Read More

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http://dx.doi.org/10.1016/j.ejpn.2018.08.005DOI Listing
November 2018
10 Reads

Electroencephalography and brain magnetic resonance imaging in asphyxia comparing cooled and non-cooled infants.

Eur J Paediatr Neurol 2019 Jan 12;23(1):181-190. Epub 2018 Sep 12.

Department of Pediatrics, Division of Neonatology, Erasmus MC-Sophia Children's Hospital, Wytemaweg 80, 3015 CN, Rotterdam, the Netherlands; Department of Pediatrics, Division of Neonatology, Wilhelmina Children's Hospital, University Medical Center, Heidelberglaan 100, 3584 CX, Utrecht, the Netherlands. Electronic address:

Objective: The aim was to establish any differences in the predictive value of EEG and MRI for outcome in infants treated and not-treated with therapeutic hypothermia (HT) for perinatal asphyxia. We hypothesize that they are equally predictive and that combining both has the highest predictive value.

Study Design: We retrospectively compared data of infants with hypoxic-ischemic encephalopathy (HIE) who received HT (n = 45) between September 2009 and December 2013 with those of infants with HIE born between January 2004 and August 2009, before HT was available (NT, n = 37). Read More

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http://dx.doi.org/10.1016/j.ejpn.2018.09.001DOI Listing
January 2019
3 Reads
1.934 Impact Factor

Polysomnographic findings in Rett syndrome.

Eur J Paediatr Neurol 2019 Jan 12;23(1):214-221. Epub 2018 Sep 12.

Pediatric Noninvasive Ventilation and Sleep Unit, AP-HP, Hôpital Necker-Enfants Malades, Paris, France; Paris Descartes University, Paris, France; Research Unit INSERM U 955, Team 13, Créteil, France.

Introduction: Rett syndrome (RS) is a severe neurodevelopment disorder associated with abnormal breathing during wakefulness and disturbed nocturnal behaviour. Breathing abnormalities during daytime have been extensively reported but polysomnographic (PSG) findings have been poorly studied.

Materials And Methods: Consecutive patients with RS carrying distinct mutations in MECP2 gene, who underwent a PSG between October 2014 and January 2018, were included in the study. Read More

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http://dx.doi.org/10.1016/j.ejpn.2018.09.003DOI Listing
January 2019
15 Reads