292,673 results match your criteria European Journal of Ophthalmology[Journal]
Yonsei Med J 2019 Jan;60(1):10-21
Division of Rheumatology, Department of Internal Medicine, and Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul, Korea.
Antineutrophil cytoplasmic antibody-associated vasculitis (AAV) is a group of systemic necrotising vasculitides, which often involve small vessels, and which lead to few or no immune deposits in affected organs. According to clinical manifestations and pathological features, AAV is classified into three variants: microscopic polyangiitis, granulomatosis with polyangiitis (GPA), and eosinophilic GPA. The American College of Rheumatology 1990 criteria contributed to the classification of AAV, although currently the algorithm suggested by the European Medicines Agency in 2007 and the Chapel Hill Consensus Conference Nomenclature of Vasculitides proposed in 2012 have encouraged physicians to classify AAV patients properly. Read More
Environ Geochem Health 2018 Dec 15. Epub 2018 Dec 15.
Geological Survey of Slovenia, Dimičeva ulica 14, 1000, Ljubljana, Slovenia.
Street dust (SD) acts as a sink and a source of atmospheric particulate matter, which is especially significant in urban environments. World studies of natural and anthropogenic impacts on the elemental composition of SD are generally limited to specific areas or case studies. The objectives of this study are to determine the impacts of different anthropogenic atmospheric dust emitters and natural factors on the chemical composition of SD, and to define sources of variance in elemental composition of SD, temporal variations and geochemical associations of elements on large number of samples, collected in different time periods, anthropogenic environments and geological settings. Read More
Radiol Med 2018 Dec 15. Epub 2018 Dec 15.
S. C. Radioterapia, ASST dei Sette Laghi-Ospedale di Circolo e Fondazione Macchi, Varese, Italy.
Aims: To evaluate the use of radiotherapy (RT) for oligometastatic cancer (OMC) among radiation oncologists in Lombardy, Italy.
Methods And Study Design: A survey with 12 items regarding data of 2016 was sent to all 34 Lombardy RT centers. The survey included six general items and six specific items regarding patient/disease/treatment characteristics. Read More
Adv Ther 2018 Dec 15. Epub 2018 Dec 15.
Analytical Method Development Team, Samsung Bioepis Co., Ltd., Incheon, South Korea.
Introduction: Tumor necrosis factor (TNF-alpha) inhibitors, such as adalimumab, have shown success in treating autoimmune inflammatory diseases but are associated with substantial financial burdens to the healthcare system. Biosimilars, which are highly similar to biologic agents, offer the potential to reduce the financial burden of treatment. In the case of TNF-alpha inhibitors, they may also offer improved stability and enable prolonged use. Read More
Clin Oral Investig 2018 Dec 15. Epub 2018 Dec 15.
Department of Preventive and Social Dentistry, School of Dentistry, Seoul National University, 101 Daehak-ro, Jongno-gu, Seoul, 03080, South Korea.
Objectives: Saliva is a bodily fluid transuded from gingival crevice fluid and blood and contains many proteins. Proteins in saliva have been studied as markers for periodontal diseases. Mass spectrometric analysis is applied to investigate biomarker proteins that are related to periodontitis. Read More
Environ Sci Pollut Res Int 2018 Dec 15. Epub 2018 Dec 15.
Faculty of Food Engineering, Stefan cel Mare University of Suceava, 13 Universitatii Street, 720229, Suceava, Romania.
Worldwide, large amounts of food are wasted every year. Reducing of food waste at European level is taken very seriously and it has been adopted even a target of reducing the amount of food waste in half until 2030. In many countries of the European Union, food wastes are composted, while in countries like Romania, the composting is too little used or not at all, but efforts are being made to apply this process. Read More
Environ Monit Assess 2018 Dec 15;191(1):19. Epub 2018 Dec 15.
Wrocław University of Environmental and Life Sciences, Institute of Soil Science and Environmental Protection, Grunwaldzka 53, 50-357, Wrocław, Poland.
The legal regulatory/action levels of trace elements in soils are established at high concentrations, at which the crucial functions of soil are at risk or are eliminated. However, concentrations below these action levels, but above presumed natural levels, may also limit particular ecosystem services, including organic food production. Thus, defining the (ambient) background concentrations is an essential part of environmental or health risk assessment, e. Read More
Ann Ig 2019 Jan-Feb;31(1):76-85
Department of Medical and Surgical Sciences and Translational Medicine, Sapienza University of Rome, Rome, Italy.
Ice cream is a widely enjoyed food that is especially popular during summer. To ensure it is safe and ready-to-eat for consumers, legislation imposes a series of obligations for food business operators, and for competent authorities that have to carry out official controls, including official sampling. This article reviews the general and specific requirements applicable to the premises where ice cream is produced, concerning aspects related to health notification obligations and to implementing and maintaining procedures based on the principles of the Hazard Analysis and Critical Control Point system. Read More
Digestion 2018 Dec 14:1-10. Epub 2018 Dec 14.
Department of Gastroenterology, Asahi General Hospital, Chiba, Japan.
Background/aims: Feeding recommendations after endoscopic submucosal dissection (ESD) for gastric neoplasms are not established and based on clinical experience.
Methods: This was a prospective pilot randomized controlled trial. Patients undergoing ESD for gastric neoplasms were randomly assigned to solid (n = 50) or liquid diet (n = 50) groups. Read More
J Neurol Neurosurg Psychiatry 2018 Dec 15. Epub 2018 Dec 15.
Department of Clinical Genetics, Maastricht University Medical Centre, Maastricht, The Netherlands
Background: Neuropathic pain is common in peripheral neuropathy. Recent genetic studies have linked pathogenic voltage-gated sodium channel (VGSC) variants to human pain disorders. Our aims are to determine the frequency of , and variants in patients with pure small fibre neuropathy (SFN), analyse their clinical features and provide a rationale for genetic screening. Read More
J Neurol Neurosurg Psychiatry 2018 Dec 15. Epub 2018 Dec 15.
Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK
Objective: Many studies examining stroke outcomes focus on more severe strokes or have short follow-up periods, so the long-term outcomes post-minor ischaemic stroke are unclear.
Methods: We recruited participants from inpatient and outpatient services with a lacunar or minor cortical ischaemic stroke (National Institutes of Health Stroke Scale score <8) and assessed current and premorbid cognitive functioning (Addenbrooke's Cognitive Examination-Revised (ACE-R), National Adult Reading Test (NART)), physical functioning (Timed Get Up and Go (TUG), 9-Hole Peg Test (9HPT)), dependency (modified Rankin Scale (mRS)), depression (Beck's Depression Inventory) in-person and remotely (Stroke Impact Scale).
Results: We followed up 224/264 participants at 3 years (mean age at index stroke=67, 126 (56%) men, 25 non-contactable, 15 declined): 66/151 (44%) had cognitive impairment, mean ACE-R 88 (SD 9, range 54-100/100), 61/156 (39%) had depression and 26/223 (12%) were dependent (mRS=3-5). Read More
Photodiagnosis Photodyn Ther 2018 Dec 13. Epub 2018 Dec 13.
Biosciences, College of Life and Environmental Sciences, University of Exeter, Geoffrey Pope Building, Stocker Road, Exeter, Devon, EX4 4QD, UK.
Background: Photodynamic therapy (PDT) is a light activated drug therapy that can be used to treat a number of cancers and precancers. It is particularly useful in its topical form in dermatology but improvement of efficacy is required to widen its application.
Methods: An ester between aminolaevulinic acid (ALA) and CP94 was synthesised (AP2-18) and experimentally evaluated to determine whether protoporphyrin IX (PpIX)-induced PDT effectiveness could be improved. Read More
Pharmacol Res 2018 Dec 13. Epub 2018 Dec 13.
GRAP UMR1247, INSERM, Centre Universitaire de Recherche en Santé, Université de Picardie Jules Verne, Amiens, France. Electronic address:
Enferm Infecc Microbiol Clin 2018 Dec 12. Epub 2018 Dec 12.
Microbiology and Immunology Department, Interdisciplinary Research Centre Egas Moniz (CiiEM), Faculty of Pharmacy, University of Lisbon, 1649-003, Lisbon, Portugal.
Introduction: The rapid and complex evolution of bacterial resistance mechanisms in Klebsiella pneumoniae producing extended-spectrum β-lactamases and carbapenemases in Klebsiella pneumoniae is one of the most significant threats to public health. However, questions and controversies regarding the interactions between resistance and virulence in multidrug-resistant K. pneumoniae isolates remain unclear. Read More
Pathol Res Pract 2018 Dec 5. Epub 2018 Dec 5.
Institute for History, Theory and Ethics of Medicine, Medical Faculty, RWTH Aachen University, Wendlingweg 2, 52074 Germany. Electronic address:
The name of the Hamburg pathologist Carl August Krauspe (1895-1983) is closely linked to the history of the "European Society of Pathology" (ESP) and the "German Pathological Society" (DGP): He was one of the founding fathers of the ESP, became its vice president, and was appointed an honorary member in 1983. From 1953-1962 he also served as secretary of the DGP and editor of the association's proceedings. In 1962/63 he finally held the chairmanship of the DGP. Read More
J Thorac Cardiovasc Surg 2018 Nov 15. Epub 2018 Nov 15.
Division of Thoracic Surgery, European Institute of Oncology, IRCCS, Milan, Italy; Department of Oncology and Hematology-Oncology-DIPO, University of Milan, Milan, Italy.
Prev Vet Med 2018 Dec 5. Epub 2018 Dec 5.
European Food Safety Authority, Via Carlo Magno 1A, 43126 Parma, Italy.
Despite the wide use of the live attenuated Neethling lumpy skin disease (LSD) vaccine, only limited data existed on its efficacy and effectiveness prior to the large LSD epidemic in the Balkans, which took place during 2016-2017. In addition, analysis of risk factors for the disease was hardly performed with proper control for vaccination effects and potential differences in exposure to the virus. Data from the LSD epidemics in six Balkan countries (Bulgaria, Greece, Serbia, Montenegro, Former Yugoslav Republic of Macedonia (FYROM) and Albania) affected during 2016 were analyzed to determine vaccine effectiveness (VE) and risk factors for LSD infection at the farm level. Read More
Neurobiol Aging 2018 Nov 16. Epub 2018 Nov 16.
School of Biology, College of Science, University of Tehran, Tehran, Iran; Department of Biotechnology, College of Science, University of Tehran, Tehran, Iran. Electronic address:
Mutations in the same gene are sometimes the cause of different clinically diagnosed neurologic disorders; this emphasizes interrelationships between various neurologic diseases. In this light, we screened SLC52A3, which is the cause of Brown-Vialetto-Van Laere syndrome, and C19orf12, which is the cause of neurodegeneration with brain iron accumulation in 60 Iranian amyotrophic lateral sclerosis (ALS) patients without mutations in the 2 most important ALS-causing genes, SOD1 and C9orf72. To the best of our knowledge, neither SLC52A3 nor C19orf12 has been mutation-screened previously in ALS cohorts. Read More
Cancer Genet 2018 Dec 6;228-229:93-97. Epub 2018 Oct 6.
Molecular Oncology Research Center, Barretos Cancer Hospital, R. Antenor Duarte Villela, 1331. Barretos 14784-400, São Paulo, Brazil; Barretos School of Health Science, Dr. Paulo Prata. Av. Loja Maçonica Renovadora, 68. Barretos 14785-002, São Paulo, Brazil. Electronic address:
Portuguese immigration to Brazil occurred in several waves and greatly contributed to the genetic composition of current Brazilian population. In this study, we evaluated the frequency of a Portuguese founder Alu insertion in BRCA2 exon 3 (c.156_157insAlu) among individuals fulfilling Hereditary Breast and Ovarian Cancer (HBOC) syndrome criteria in 1,380 unrelated families originated from three distinct Brazilian States. Read More
J Safety Res 2018 Dec 21;67:155-163. Epub 2018 Oct 21.
Laboratory of Health and Road Safety, Department of Social Work, School of Health and Social Welfare, Technological Educational Institute of Crete, Estavromenos, P.C. 71004 Heraklion, Greece. Electronic address:
Introduction: This study aimed to assess the physical, psychological, and economic burden shouldered by severely injured two-wheel users in three European countries as well as the cost resulting from their hospitalization.
Methods: A total of seven public hospitals were involved in three countries: Greece, Italy, and Germany. Participants enrolled during a 12-month period starting in April 2013. Read More
Carbohydr Polym 2019 Feb 13;206:380-388. Epub 2018 Nov 13.
Laboratory of Enzyme Engineering and Microbiology, National School of Engineering of Sfax (ENIS), University of Sfax, P.O. Box 1173, Sfax, 3038, Tunisia.
A novel water-soluble polysaccharide named PLP1 was successfully isolated from root barks of Periploca laevigata by hot water extraction and further purified by DEAE-sepharose chromatography. PLP1 has a relative molar mass of 5.57 10 g/mol determined by Ultra-high performance liquid chromatography (UHPLC). Read More
Carbohydr Polym 2019 Feb 2;206:210-219. Epub 2018 Nov 2.
"Petru Poni" Institute of Macromolecular Chemistry, European Polysaccharide Network of Excellence (EPNOE), 41-A, Grigore Ghica Voda Alley, 700487, Iasi, Romania.
Composite hydrogels of poly(vinyl alcohol) (PVA) and C-fully oxidized pullulan (OxP) were prepared and investigated. Hydrogels with different content of OxP into the PVA matrix were prepared by freezing/thawing method. FTIR and NMR were used to assess the degree of interaction between the two polymers into the physical network. Read More
Breast 2018 Dec 6;43:130-134. Epub 2018 Dec 6.
IEO, European Institute of Oncology IRCCS, Milan, Italy; Department of Oncology and Hematology, University of Milano, Milan, Italy. Electronic address:
Histone deacetylase inhibitors (HDACi) are a relatively new class of drug that plays an important role in the epigenetic and non-epigenetic regulation in cancer, inducing death, apoptosis and cell cycle arrest in cancer cells. Although HDACi are approved only for hematologic malignancies, there are several trials in the breast cancer setting with promising results. In this review, we summarize the latest studies with HDACi in breast cancer from the emerging data in the translational research until its possible applicability in the clinical practice. Read More
Parasitol Int 2018 Dec 12. Epub 2018 Dec 12.
University of Zurich, Vetsuisse Faculty, Institute of Parasitology, Winterthurerstrasse 266a, 8057 Zurich, Switzerland. Electronic address:
Endoparasitic infections represent relevant causes of respiratory and gastrointestinal diseases in cats. The aim of the study was to investigate the occurrence of endoparasites in Swiss cats in order to evaluate the risk of onset of parasitic diseases and potential correlated zoonoses. Therefore 664 faecal samples from privately owned (n = 299), shelter (n = 197) and stray (n = 168) cats were investigated by sedimentation-flotation and 468 samples additionally by the Baermann technique. Read More
Gastroenterology 2018 Dec 12. Epub 2018 Dec 12.
Unit of Internal Medicine and Hepatology (UIMH), Department of Medicine - DIMED, University of Padova, Padova, Italy. Electronic address:
Background And Aims: Bacterial infections are common and life-threatening in patients with cirrhosis. Little is known about the epidemiology of bacterial infections in different regions. We performed a multicenter prospective intercontinental study to assess the prevalence and outcomes of bacterial and fungal infections in patients with cirrhosis. Read More
Swiss Med Wkly 2018 Nov 2;148:w14687. Epub 2018 Dec 2.
Laboratory of Virology, Division of Laboratory Medicine and Division of Infectious Diseases, University of Geneva Hospitals, Switzerland; University of Geneva Medical School, Switzerland.
Purpose: Eight confirmed cases of Legionnaires’ disease were identified at the Geneva University Hospitals between 28 July 2017 and 02 August 2017, leading to a detailed outbreak investigation.
Methods: Legionnaires’ disease cases were defined according to Swiss and European (ELDSNet) consensus guidelines. An outbreak investigation task force was put in place. Read More
Head Neck 2018 Dec 15. Epub 2018 Dec 15.
Department of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute, Brno, Czech Republic.
Background: Progress in radiation treatment of head and neck squamous cell carcinoma (HNSCC) deserves the studies focused on molecular predictors that would help to enhance individually tailored treatment.
Methods: p16/epidermal growth factor receptor (EGFR)/cluster of differentiation-44 (CD44) was immunohistochemically analyzed in 165 HNSCC patients.
Results: In the entire group and the p16 negative cohort, better 3-year overall survival and locoregional control correlated with p16 positivity, CD44, and EGFR negativity were observed. Read More
Head Neck 2018 Dec 15. Epub 2018 Dec 15.
Division of Public Health, Department of Family and Preventive Medicine, and Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah.
Background: The smoking prevalence among men in China is high, but the head and neck cancer incidence rates are low. This study's purpose was to investigate the impact of tobacco, betel quid, and alcohol on head and neck cancer risk in East Asia.
Methods: A multicenter case-control study (921 patients with head and neck cancer and 806 controls) in East Asia was conducted. Read More
Mol Oncol 2018 Dec 15. Epub 2018 Dec 15.
Huntsman Cancer Institute, Salt Lake City, Utah, USA.
Cancer survivorship has traditionally received little prioritisation and attention. For a long time, the treatment of cancer has been the main focus of healthcare providers' efforts. It is time to increase the amount of attention given to patients' long-term well-being and their ability to return to a productive and good life. Read More
Sociol Health Illn 2018 Dec 14. Epub 2018 Dec 14.
Department of Economics, University of Massachusetts, USA.
An unprecedented mortality crisis befell the former socialist countries between 1989 and 1995, representing one of the greatest demographic shocks of the period after the Second World War. While it is likely that country-level variation in the post-socialist mortality crisis in Eastern Europe can be explained by a constellation of political and socio-economic factors, no comprehensive review of the existing scholarly attempts at explaining these factors exists. We review 39 cross-national multi-variable peer reviewed studies of social determinants of mortality in post-socialist Europe in order to assess the social factors behind the post-socialist mortality crisis, determine the gaps in the existing literature and to make suggestions for future research. Read More
Am J Bot 2018 Dec 14. Epub 2018 Dec 14.
Department of Botany, Faculty of Science, Charles University, Benátská 2, CZ-128 01, Prague, Czech Republic.
Premise Of The Study: Genome duplication is associated with multiple changes at different levels, including interactions with pollinators and herbivores. Yet little is known whether polyploidy may also shape belowground interactions.
Methods: To elucidate potential ploidy-specific interactions with arbuscular mycorrhizal fungi (AMF), we compared mycorrhizal colonization and assembly of AMF communities in roots of diploid and tetraploid Centaurea stoebe s. Read More
Eur Child Adolesc Psychiatry 2018 Dec 14. Epub 2018 Dec 14.
Division of Psychiatry & Applied Psychology, University of Nottingham, Nottingham, UK.
Attention deficit hyperactivity disorder (ADHD) is a developmental disorder affecting up to 5% of children and adults and is underdiagnosed in many European countries. The process of access to care for this disorder is complex and variable across countries. In general, those affected, or their caregiver, will seek help through their primary care practitioners who are then often responsible for referral to other professionals for diagnosis and provision of treatment. Read More
Pediatr Nephrol 2018 Dec 14. Epub 2018 Dec 14.
Division of Pediatrics, Department of Medicine, Faculty of Medicine, University of Oviedo, CP 33006, Oviedo, Asturias, Spain.
Growth retardation is a major feature of chronic kidney disease (CKD) of onset in infants or children and is associated with increased morbidity and mortality. Several factors have been shown to play a causal role in the growth impairment of CKD. All these factors interfere with growth by disturbing the normal physiology of the growth plate of long bones. Read More
Aging Clin Exp Res 2018 Dec 14. Epub 2018 Dec 14.
Department of Electrophysiology, Heart Center of Leipzig, Leipzig, Germany.
Background: Cardiac implantable electronic devices (CIEDs) are widely used to treat bradyarrhythmias or improve the prognosis of patients with heart failure (HF).
Aims: To evaluate age-related (≤ 75 vs. > 75 years) attitudes, worries, psychological effects and needs in an Italian CIEDs population. Read More
Clin Res Cardiol 2018 Dec 14. Epub 2018 Dec 14.
Division of Adult Congenital and Valvular Heart Disease, Department of Cardiovascular Medicine, University Hospital Muenster, Muenster, Germany.
Background: Current trials and registries of transcatheter valve implantation (TAVI) mostly include patients older than 75 years. Little is known about younger patients who undergo this treatment. We investigated comorbidities among patients < 75 years old who underwent TAVI in the SAPIEN 3™ European post-approval SOURCE 3 Registry, and analysed outcomes at 30 days and 1 year. Read More
Surg Radiol Anat 2018 Dec 14. Epub 2018 Dec 14.
Department of Anatomy and Surgical Anatomy, School of Medicine, National and Kapodistrian University of Athens, Tetrapoleos 18, 75 Mikras Asias Str, 11527, Athens, Greece.
Purpose: The arc of Bühler, an anastomotic vessel between celiac artery and superior mesenteric artery, is a rare anatomic variation. Various radiologic and surgical procedures can be affected by its existence. We aim to review all available information and identify possible clinical implications. Read More
Radiologe 2018 Dec 14. Epub 2018 Dec 14.
Klinik für Diagnostische und Interventionelle Radiologie und Neuroradiologie, Klinikum Augsburg, Stenglinstr. 2, 86156, Augsburg, Deutschland.
Clinical/methodical Issue: Radiologic imaging for the assessment of individual cardiovascular risk.
Standard Radiological Methods: The correct estimation of the individual cardiovascular risk is prerequisite for the prevention of cardiovascular diseases. Here, extensive evidence is available for coronary calcium scans as well as coronary CT angiography (CTA). Read More
Eur Radiol 2018 Dec 14. Epub 2018 Dec 14.
Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany.
Objectives: To longitudinally investigate smoking cessation-related changes of quantitative computed tomography (QCT)-based airway metrics in a group of heavy smokers.
Methods: CT scans were acquired in a lung cancer screening population over 4 years at 12-month intervals in 284 long-term ex-smokers (ES), 405 continuously active smokers (CS), and 31 subjects who quitted smoking within 2 years after baseline CT (recent quitters, RQ). Total diameter (TD), lumen area (LA), and wall percentage (WP) of 1st-8th generation airways were computed using airway analysis software. Read More
Sci Rep 2018 Dec 14;8(1):17842. Epub 2018 Dec 14.
Istituto Italiano di Tecnologia, Social Cognition in Human-Robot Interaction, via Enrico Melen 83, 16152, Genova, Italy.
Most experimental protocols examining joint attention with the gaze cueing paradigm are "observational" and "offline", thereby not involving social interaction. We examined whether within a naturalistic online interaction, real-time eye contact influences the gaze cueing effect (GCE). We embedded gaze cueing in an interactive protocol with the iCub humanoid robot. Read More
Sci Rep 2018 Dec 14;8(1):17855. Epub 2018 Dec 14.
Department of Physics and Munich School of BioEngineering, Technical University of Munich, 85748, Garching, Germany.
Histological investigations are indispensable with regards to the identification of structural tissue details but are limited to two-dimensional images, which are often visualized in one and the same plane for comparison reasons. Nondestructive three-dimensional technologies such as X-ray micro- and nanoCT have proven to provide valuable benefits for the understanding of anatomical structures as they allow visualization of structural details in 3D and from arbitrary viewing angles. Nevertheless, low attenuation of soft tissue has hampered their application in the field of 3D virtual histology. Read More
Sci Rep 2018 Dec 14;8(1):17841. Epub 2018 Dec 14.
Optoelectronics Group - Department of Engineering, University of Sannio, I-82100, Benevento, Italy.
In this work, we report on the first demonstration of Lab on Fiber (LOF) dosimeter for ionizing radiation monitoring at ultra-high doses. The new dosimeter consists in a metallo-dielectric resonator at sub-wavelength scale supporting localized surface plasmon resonances realized on the optical fiber (OF) tip. The resonating structure involves two gold gratings separated by a templated dielectric layer of poly(methyl methacrylate) (PMMA). Read More
Transl Psychiatry 2018 Dec 14;8(1):280. Epub 2018 Dec 14.
Statistical Genomics and Data Analysis Core, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
Growing evidence suggests that the glutamatergic modulator ketamine has rapid antidepressant effects in treatment-resistant depressed subjects. The anticholinergic agent scopolamine has also shown promise as a rapid-acting antidepressant. This study applied genome-wide markers to investigate the role of genetic variants in predicting acute antidepressant response to both agents. Read More
J Exp Biol 2018 Dec 14;221(Pt 24). Epub 2018 Dec 14.
Department of Biology, Lund University, 22362 Lund, Sweden.
Insect migrations are spectacular natural events and resemble a remarkable relocation of biomass between two locations in space. Unlike the well-known migrations of daytime flying butterflies, such as the painted lady () or the monarch butterfly (), much less widely known are the migrations of nocturnal moths. These migrations - typically involving billions of moths from different taxa - have recently attracted considerable scientific attention. Read More
Mol Cancer Res 2018 Dec 14. Epub 2018 Dec 14.
European Cancer Stem Cell Research Institute, School of Biosciences, Cardiff University
Both alterations to the epigenome and loss of polarity have been linked to cancer initiation, progression and metastasis. It has previously been demonstrated that loss of the epigenetic reader protein Kaiso suppresses intestinal tumourigenesis in the Apc+/min mouse model, in which altered polarity plays a key role. Thus, we investigated the link between Kaiso deficiency, polarity and suppression of intestinal tumourigenesis. Read More
J Nucl Med 2018 Dec 14. Epub 2018 Dec 14.
Ludwig-Maximilians-University (LMU), Germany.
Gallium-prostate-specific membrane antigen positron emission tomography/computed tomography (Ga-PSMA PET/CT) offers unprecedented accuracy for staging of primary, persistent or recurrent prostate cancer. Thus, we hypothesized that PSMA PET/CT prior to radiotherapy significantly impacts the radiotherapeutic approach in comparison to the current standard of CT based approach. Between February 2014 and December 2017, a total of 172 patients received PSMA PET/CT before radiotherapy and were included in this retrospective analysis. Read More
Oncologist 2018 Dec 14. Epub 2018 Dec 14.
General Medical Research Center, Faculty of Medicine, Fukuoka University, Japan.
Background: The aim of this meta-analysis was to compare patient-reported outcomes (PROs) between programmed death receptor-1/programmed death-ligand 1 (PD-1/PD-L1) inhibitors and standard-of-care therapy in patients with advanced cancer.
Methods: We searched randomized controlled trials (RCTs) comparing single-agent PD-1/PD-L1 inhibitors (nivolumab, pembrolizumab, atezolizumab, avelumab, or durvalumab) with standard-of-care therapy in patients with advanced cancer reporting PROs with generic measures: the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 items (QLQ-C30) and the EuroQol Five Dimensions Questionnaire. The summary outcomes were changes in PROs from baseline to follow-up within and between treatment groups and time to deterioration (TTD) in PROs based on clinically meaningful change. Read More
Cancer Discov 2018 Dec 14. Epub 2018 Dec 14.
Doctors are convinced that Truxima, the first rituximab biosimilar approved by the FDA, is as effective as rituximab; European experience with the biosimilar over the last 2 years has also revealed no problems with unexpected side effects. However, cost will be a factor in determining whether doctors in the United States prescribe Truxima instead of rituximab. Read More
Lancet Respir Med 2018 Dec 11. Epub 2018 Dec 11.
Division of Respiratory Medicine, National Institute for Health Research, Nottingham Biomedical Research Centre, University of Nottingham, Nottingham, UK. Electronic address:
Background: Few genetic studies that focus on moderate-to-severe asthma exist. We aimed to identity novel genetic variants associated with moderate-to-severe asthma, see whether previously identified genetic variants for all types of asthma contribute to moderate-to-severe asthma, and provide novel mechanistic insights using expression analyses in patients with asthma.
Methods: In this genome-wide association study, we used a two-stage case-control design. Read More
Health Place 2018 Dec 10. Epub 2018 Dec 10.
JC School of Public Health and Primary Care, Faculty of Medicine, Chinese University of Hong Kong, Hong Kong. Electronic address:
The potential benefits of aquatic environments for public health have been understudied in Asia. We investigated the relationships between blue space exposures and health outcomes among a sample of predominantly older adults in Hong Kong. Those with a view of blue space from the home were more likely to report good general health, while intentional exposure was linked to greater odds of high wellbeing. Read More
Can J Diabetes 2018 Oct 9. Epub 2018 Oct 9.
Indigenous and Global Health Research Group, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada. Electronic address:
Objectives: The Canadian Diabetes Risk Assessment Questionnaire (CANRISK) is a validated, evidence-based, self-administered tool to assess the risk for type 2 diabetes mellitus in multiethnic Canadian adults. Identifying individuals at high risk for type 2 diabetes allows early intervention that improves modifiable risk factors. This study examined the risk factors for type 2 diabetes in multiethnic urban youth in Edmonton, Alberta. Read More