292,592 results match your criteria European Journal of Nutrition [Journal]


Diagnostic leukapheresis for CTC analysis in breast cancer patients: CTC frequency, clinical experiences and recommendations for standardized reporting.

Cytometry A 2018 Dec;93(12):1213-1219

Faculty of the Heinrich-Heine, General, Visceral and Pediatric Surgery, University Hospital and Medical Faculty, University Düsseldorf, Düsseldorf, North Rhine-Westphalia, Germany.

Diagnostic leukapheresis (DLA) is based on continuous centrifugation that collects mononuclear cells from peripheral blood with a density of 1.055-1.08 g/ml. Read More

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December 2018

DEPArray™ system: An automatic image-based sorter for isolation of pure circulating tumor cells.

Cytometry A 2018 Dec;93(12):1260-1266

Menarini Silicon Biosystems S.p.A, Bologna, Italy.

Circulating tumor cells (CTCs) are rare cells shed into the bloodstream by invasive tumors and their analysis offers a promising noninvasive tool to predict and monitor therapeutic responses. CTCs can be isolated from patient blood and their characterization at single-cell level can inform on the genomic landscape of a tumor. All CTC enrichment methods bear a burden of contaminating normal cells, which mandate a further step of purification to enable reliable downstream genetic analysis. Read More

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December 2018

Polychaete mucopolysaccharide alters sediment microbial diversity and stimulates ammonia-oxidising functional groups.

FEMS Microbiol Ecol 2018 Dec 14. Epub 2018 Dec 14.

Marine Biological Association of the United Kingdom, The Laboratory, Citadel Hill, Plymouth, PL1 2PB.

Sediment nitrogen cycling is a network of microbially-mediated biogeochemical processes that are vital in regulating ecosystem functioning. Mucopolysaccharides (mucus) are produced by many invertebrates and have the potential to be an important source of organic carbon and nitrogen to sediment microorganisms. At present, we have limited understanding of how mucopolysaccharide moderates total sediment microbial communities and specific microbial functional groups that drive nitrogen cycling processes. Read More

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December 2018
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Renal relapse in antineutrophil cytoplasmic autoantibody-associated vasculitis: unpredictable, but predictive of renal outcome.

Rheumatology (Oxford) 2019 Jan;58(1):103-109

Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.

Objectives: To determine predictors of renal relapse and end-stage renal failure (ESRF) in patients with ANCA-associated vasculitis.

Methods: Data from four European Vasculitis Society randomized controlled trials, conducted roughly simultaneously between 15 March 1995 and 30 September 2002, was pooled to determine predictors of long-term renal outcome. The respective trial inclusion criteria covered the entire spectrum of disease severity. Read More

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January 2019

Measuring mental well-being in Denmark: Validation of the original and short version of the Warwick-Edinburgh mental well-being scale (WEMWBS and SWEMWBS) and cross-cultural comparison across four European settings.

Psychiatry Res 2018 Dec 5;271:502-509. Epub 2018 Dec 5.

The Danish National Institute of Public Health, University of Southern Denmark, Studiestraede 6, 1455 Copenhagen, Denmark. Electronic address:

This study examined the psychometric properties of the Danish WEMWBS and its short version (SWEMWBS) in a Danish population sample, and compared scores in Denmark with scores representative of three other European settings. A total of 3,508 Danish men and women aged 16-95 filled out an electronic survey. Face validity was examined by cognitive interviews. Read More

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December 2018

Targeted and untargeted LC-MS polyphenolic profiling and chemometric analysis of propolis from different regions of Croatia.

J Pharm Biomed Anal 2018 Dec 4;165:162-172. Epub 2018 Dec 4.

University of Rijeka, Department of Biotechnology, Centre for high-throughput technologies, Radmile Matejčić 2, 51000 Rijeka, Croatia. Electronic address:

Propolis is a complex biological matrix consisting mostly of plant resins and waxes, and in a small proportion of the herbal secondary metabolites, phenols. Phenols are components that are responsible for biological activities of propolis, however, their qualitative and quantitative composition is strongly influenced by climate and vegetation. Although studies on profiling of propolis samples from different countries have been carried out for some time propolis from Croatia is still not characterized till now. Read More

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December 2018

Vertico-horizontal atlantoaxial index (VHAI): A new craniovertebral radiographic index.

Clin Neurol Neurosurg 2018 Dec 3;176:83-88. Epub 2018 Dec 3.

Department of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. Electronic address:

Objective: The purpose of this study was to develop a new index that can reliably quantify the reduction of basilar invagination with atlantoaxial dislocation.

Patients And Methods: Between May 2012 and September 2017, 40 patients with congenital basilar invagination and atlantoaxial dislocation as well as 100 sex-and age-matched control subjects were recruited for this study. All patients underwent direct posterior reduction and fixation. Read More

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December 2018

Linking biodiversity to ecosystem services supply: Patterns across aquatic ecosystems.

Sci Total Environ 2018 Dec 3;657:517-534. Epub 2018 Dec 3.

Department of Biology & CESAM, University of Aveiro, Campus de Santiago, 3810-193 Aveiro, Portugal.

Global initiatives have been increasingly focusing on mainstreaming the values of biodiversity and ecosystem services into decision-making at all levels. Due to the accelerated rate at which biodiversity is declining and its consequences for the functioning of ecosystems and subsequently, the services they provide, there is need to develop comprehensive assessments of the services and the benefits nature delivers to society. Based on expert evaluation, we identified relevant flow linkages in the supply-side of the socio-ecological system, i. Read More

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December 2018
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West Nile virus epizootic in Germany, 2018.

Antiviral Res 2018 Dec 11. Epub 2018 Dec 11.

Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Institute of Novel and Emerging Infectious Diseases, Greifswald-Insel Riems, Germany; German Centre for Infection Research (DZIF), Partner Site Hamburg-Luebeck-Borstel, Greifswald-Insel Riems, Germany. Electronic address:

The summer of 2018 in Germany was the second hottest and driest on record. These generally extremely favorable climatic conditions most likely triggered the further expansion and the efficient propagation of the zoonotic arthropod-borne West Nile virus in many Southern/Southeastern and even Central European countries. WNV infections were detected for the first time in resident wild and aviary birds, such as common blackbirds, northern goshawks and great grey owls in Eastern and Southeastern Germany. Read More

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December 2018

The role of RNA adenosine demethylases in the control of gene expression.

Biochim Biophys Acta Gene Regul Mech 2018 Dec 11. Epub 2018 Dec 11.

Central European Institute of Technology (CEITEC), Masaryk University, Brno 625 00, Czech Republic. Electronic address:

RNA modifications are being recognized as an essential factor in gene expression regulation. They play essential roles in germ line development, differentiation and disease. In eukaryotic mRNAs, N-adenosine methylation (mA) is the most prevalent internal chemical modification identified to date. Read More

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December 2018

Novel aspects of PCSK9 and lipoprotein receptors in renal disease-related dyslipidemia.

Cell Signal 2018 Dec 11. Epub 2018 Dec 11.

Dept. of Nephrology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.

Chronic kidney disease (CKD) is a global health problem with a profound impact on quality of life. Cardiovascular disease is established as a major cause of morbidity and mortality in patients with CKD. Dyslipidemia is frequently observed in CKD patients, suggesting a causal relation between dyslipidemia and cardiovascular disease in CKD patients. Read More

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December 2018

Mortality of patients with chronic disease: an increasing problem.

J Pediatr (Rio J) 2018 Dec 11. Epub 2018 Dec 11.

Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria, Pediatric Intensive Care Unit, Madrid, Spain; Maternal and Child Health and Development Network, RETICS funded by the PN I+D+I 2013-2016 (Spain), ISCIII-Sub-Directorate General for Research Assessment and Promotion and the European Regional Development Fund (ERDF), Spain; Universidad Complutense de Madrid, Facultad de Medicina, Departamento de Salud Pública y Maternoinfantil, Madrid, Spain. Electronic address:

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December 2018

Phenotypic variability and neuropsychological findings associated with C9orf72 repeat expansions in a Bulgarian dementia cohort.

PLoS One 2018 14;13(12):e0208383. Epub 2018 Dec 14.

Karolinska Institutet, Dept NVS, Division for Neurogeriatrics, Bioclinicum, Akademiska stråket, Solna, Sweden.

Background: The GGGGCC repeat expansion in the C9orf72 gene was recently identified as a major cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) in several European populations. The objective of this study was to determine the frequency of C9orf72 repeat expansions in a Bulgarian dementia cohort and to delineate the associated clinical features.

Methods And Findings: PCR-based assessments of the C9orf72 hexanucleotide repeat expansion in all study samples (including 82 FTD, 37 Alzheimer's disease (AD), and 16 other neurodegenerative/dementia disorder cases) were performed. Read More

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December 2018

Interventions to treat cutaneous leishmaniasis in children: A systematic review.

PLoS Negl Trop Dis 2018 Dec 14;12(12):e0006986. Epub 2018 Dec 14.

Unidad Clínica de Leishmaniasis, Centro Internacional de Entrenamiento e Investigaciones Médicas (CIDEIM), Cali, Colombia.

Background: Case management in children with cutaneous leishmaniasis (CL) is mainly based on studies performed in adults. We aimed to determine the efficacy and harms of interventions to treat CL in children.

Methods: We conducted a systematic review of clinical trials and cohort studies, assessing treatments of CL in children (≤12 years old). Read More

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December 2018

Overestimation of an outbreak of Enterobacter cloacae in a neonatal intensive care unit in Germany, 2015.

Pediatr Infect Dis J 2018 Dec 13. Epub 2018 Dec 13.

Department for Infectious Disease Epidemiology, Robert Koch-Institute, Germany.

Background: In August 2015 seventeen neonates with Enterobacter (E.) cloacae colonisation were identified in a neonatal intensive care unit (NICU) in Germany. Two developed severe brain abscesses. Read More

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December 2018

Society of Cardiovascular Anesthesiologists/European Association of Cardiothoracic Anaesthetists Practice Advisory for the Management of Perioperative Atrial Fibrillation in Patients Undergoing Cardiac Surgery.

Anesth Analg 2019 Jan;128(1):33-42

Department of Perioperative Medicine, Barts Heart Centre, St Bartholomew's Hospital, London, United Kingdom.

Postoperative atrial fibrillation (poAF) is the most common adverse event after cardiac surgery and is associated with increased morbidity, mortality, and hospital and intensive care unit length of stay. Despite progressive improvements in overall cardiac surgical operative mortality and postoperative morbidity, the incidence of poAF has remained unchanged at 30%-50%. A number of evidence-based recommendations regarding the perioperative management of atrial fibrillation (AF) have been released from leading cardiovascular societies in recent years; however, it is unknown how closely these guidelines are being followed by medical practitioners. Read More

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January 2019

Compliance with vaccination schedules.

Hum Vaccin Immunother 2018 Dec 14. Epub 2018 Dec 14.

a Medical School , European University , Cyprus.

Childhood immunization is amongst the most cost-effective public health interventions for reducing children's morbidity and mortality. Vaccination coverage is commonly used to assess the vaccination status of a community. Adherence to schedule is critical for providing maximum effectiveness against vaccine-preventable diseases in the community. Read More

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December 2018

Bone-targeted agent treatment patterns and the impact of bone metastases on patients with advanced breast cancer in the United States.

Curr Med Res Opin 2018 Dec 14:1-16. Epub 2018 Dec 14.

e Global Health Economics, Amgen Inc. , Thousand Oaks , CA , USA.

Objective: Bone metastases are common among patients with advanced breast cancer, putting patients at increased risk of skeletal-related events (SREs). This study described impact of bone metastases, utilization of bone-targeted agents (BTAs) and physicians' decision processes for BTA use in advanced breast cancer.

Methods: Data were collected using the Adelphi Breast Cancer Disease-Specific Programme in the United States. Read More

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December 2018
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Compatibility of CO laser surgery and fluorescence detection in head and neck cancer cells.

Head Neck 2018 Dec 14. Epub 2018 Dec 14.

Department of Otorhinolaryngology and Head and Neck Surgery, Radboud University Medical Center, Nijmegen, The Netherlands.

Background: Surgical treatment of cancer requires tumor excision with emphasis on function preservation which is achieved in (early stage) laryngeal cancer by transoral carbon dioxide (CO ) laser surgery. Whereas conventional laser surgery is restricted by the surgeon's visual recognition of tumor tissue, new approaches based on fluorescence-guided surgery (FGS) improve the detection of the tumor and its margin. However, it is unclear whether fluorophores are compatible with high-power laser application or whether precision is compromised by laser-induced bleaching of the dye. Read More

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December 2018

The sensitivity of the forest carbon budget shifts across processes along with stand development and climate change.

Ecol Appl 2018 Dec 14. Epub 2018 Dec 14.

National Research Council of Italy, Institute for Agriculture and Forestry Systems, in the Mediterranean (CNR-ISAFOM), 87036, Rende, CS, Italy.

The future trajectory of atmospheric CO concentration depends on the development of the terrestrial carbon sink, which in turn is influenced by forest dynamics under changing environmental conditions. An in-depth understanding of model sensitivities and uncertainties in non steady-state conditions is necessary for reliable and robust projections of forest development and under scenarios of global warming and CO -enrichment. Here, we systematically assessed if a bio-geochemical process-based model (3D-CMCC-CNR), which embeds similarities with many other vegetation models, applied in simulating net primary productivity (NPP) and standing woody biomass (SWB), maintained a consistent sensitivity to its 55 input parameters through time, during forest-ageing and -structuring as well as under climate-change scenarios. Read More

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December 2018

Coding of Experimental Conditions in Microfluidic Droplet Assays Using Colored Beads and Machine Learning Supported Image Analysis.

Small 2018 Dec 14:e1802384. Epub 2018 Dec 14.

Bio Pilot Plant, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute, 07745, Jena, Germany.

To efficiently exploit the potential of several millions of droplets that can be considered as individual bioreactors in microfluidic experiments, methods to encode different experimental conditions in droplets are needed. The approach presented here is based on coencapsulation of colored polystyrene beads with biological samples. The decoding of the droplets, as well as content quantification, are performed by automated analysis of triggered images of individual droplets in-flow using bright-field microscopy. Read More

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December 2018

Estimating the global distribution of field size using crowdsourcing.

Glob Chang Biol 2019 Jan 22;25(1):174-186. Epub 2018 Nov 22.

International Institute for Applied Systems Analysis, ESM, Laxenburg, Austria.

There is an increasing evidence that smallholder farms contribute substantially to food production globally, yet spatially explicit data on agricultural field sizes are currently lacking. Automated field size delineation using remote sensing or the estimation of average farm size at subnational level using census data are two approaches that have been used. However, both have limitations, for example, automatic field size delineation using remote sensing has not yet been implemented at a global scale while the spatial resolution is very coarse when using census data. Read More

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January 2019

Climate change impact and adaptation for wheat protein.

Glob Chang Biol 2019 Jan 22;25(1):155-173. Epub 2018 Nov 22.

Institute of Crop Science and Resource Conservation INRES, University of Bonn, Bonn, Germany.

Wheat grain protein concentration is an important determinant of wheat quality for human nutrition that is often overlooked in efforts to improve crop production. We tested and applied a 32-multi-model ensemble to simulate global wheat yield and quality in a changing climate. Potential benefits of elevated atmospheric CO concentration by 2050 on global wheat grain and protein yield are likely to be negated by impacts from rising temperature and changes in rainfall, but with considerable disparities between regions. Read More

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January 2019

An antibiofilm coating of 5-aryl-2-aminoimidazole covalently attached to a titanium surface.

J Biomed Mater Res B Appl Biomater 2018 Dec 13. Epub 2018 Dec 13.

Department of Microbial and Molecular Systems, Centre of Microbial and Plant Genetics (CMPG), KU Leuven, Kasteelpark Arenberg 20 Box 2460, 3001 Leuven, Belgium.

Biofilms, especially those formed by Staphylococcus aureus, play a key role in the development of orthopedic implant infections. Eradication of these infections is challenging due to the elevated tolerance of biofilm cells against antimicrobial agents. In this study, we developed an antibiofilm coating consisting of 5-(4-bromophenyl)-N-cyclopentyl-1-octyl-1H-imidazol-2-amine, designated as LC0024, covalently bound to a titanium implant surface (LC0024-Ti). Read More

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December 2018

Black Phosphorus Cytotoxicity Assessments Pitfalls: Advantages and Disadvantages of Metabolic and Morphological Assays.

Chemistry 2018 Dec 13. Epub 2018 Dec 13.

Department of Inorganic Chemistry, University of Chemistry and Technology Prague, Technická 5, 166 28, Prague 6, Czech Republic.

Black phosphorus (BP) belongs to a group of 2D nanomaterials and nowadays attracts constantly increasing attention. Parallel to the growing utilization of BP nanomaterial increase also the requirements for the thorough comprehension of its potential impact on human and animal health. The aim of this study was to compare and discuss five assays commonly used for the cytotoxicity assessments of nanomaterials with a special focus on BP nanoparticles. Read More

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December 2018

Using density based indexes to characterize excited states evolution.

J Comput Chem 2018 Dec 14. Epub 2018 Dec 14.

Chimie ParisTech, PSL Research University, CNRS, Institut de Recherche de Chimie Paris, F-75005, Paris, France.

With the aim of offering new computational tools helping in the description of photochemical reactions and phenomena occurring at the excited state, we present in this work the capability of a density based index (Π) in locating decay channels from higher to lower excited states. The Π index, previously applied to disclose non-radiative decay channels from the first excited state to the ground state, is very simple in its formulation and can be evaluated, practically with no extra computational cost, and coupled to any quantum method able to provide excited states densities. Indeed, this index relies only on the knowledge of energetics and electron densities of the different electronic states involved in the decay. Read More

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December 2018

Pressure pain sensitivity is associated with dental fear in adults in middle age: Findings from the Northern Finland 1966 birth cohort study.

Community Dent Oral Epidemiol 2018 Dec 13. Epub 2018 Dec 13.

Department of Community Dentistry, University of Turku, Turku, Finland.

Introduction: Dental fear is a prevalent problem leading to severe deterioration of oral health and health-related quality of life. Despite the knowledge that dental fear is closely linked to painful experience, the association between pain sensitivity and dental fear remains unclear. This study was designed to evaluate this association with validated measures of dental fear and pressure pain sensitivity in a cohort population. Read More

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December 2018

Big data analysis of ab Initio molecular integrals in the neglect of diatomic differential overlap approximation.

J Comput Chem 2018 Dec 14. Epub 2018 Dec 14.

Max-Planck-Institut für Kohlenforschung, 45470, Mülheim an der Ruhr, Germany.

Most modern semiempirical quantum-chemical (SQC) methods are based on the neglect of diatomic differential overlap (NDDO) approximation to ab initio molecular integrals. Here, we check the validity of this approximation by computing all relevant integrals for 32 typical organic molecules using Gaussian-type orbitals and various basis sets (from valence-only minimal to all-electron triple-ζ basis sets) covering in total more than 15.6 million one-electron (1-e) and 10. Read More

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December 2018

Sublaminar organization of the human subplate: developmental changes in the distribution of neurons, glia, growing axons and extracellular matrix.

J Anat 2018 Dec 13. Epub 2018 Dec 13.

Croatian Institute for Brain Research, School of Medicine, University of Zagreb, Zagreb, Croatia.

The objective of this paper was to collect normative data essential for analyzing the subplate (SP) role in pathogenesis of developmental disorders, characterized by abnormal circuitry, such as hypoxic-ischemic lesions, autism and schizophrenia. The main cytological features of the SP, such as low cell density, early differentiation of neurons and glia, plexiform arrangement of axons and dendrites, presence of synapses and a large amount of extracellular matrix (ECM) distinguish this compartment from the cell-dense cortical plate (CP; towards pia) and large fiber bundles of external axonal strata of fetal white matter (towards ventricle). For SP delineation from these adjacent layers based on combined cytological criteria, we analyzed the sublaminar distribution of different microstructural elements and the associated maturational gradients throughout development, using immunocytochemical and histological techniques on postmortem brain material (Zagreb Neuroembryological Collection). Read More

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December 2018

Geographical adaptation prevails over species-specific determinism in trees' vulnerability to climate change at Mediterranean rear-edge forests.

Glob Chang Biol 2018 Dec 13. Epub 2018 Dec 13.

Ecoclimatology, Department of Ecology and Ecosystem Management, Technische Universität München, Freising, Germany.

Climate change may reduce forest growth and increase forest mortality, which is connected to high carbon costs through reductions in gross primary production and net ecosystem exchange. Yet the spatiotemporal patterns of vulnerability to both short-term extreme events as well as gradual environmental changes are quite uncertain across the species' limits of tolerance to dryness. Such information is fundamental for defining ecologically relevant upper limits of species tolerance to drought and hence, to predict the risk of increased forest mortality and shifts in species composition. Read More

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December 2018

A Fluorogenic Probe for Cell Surface Phosphatidylserine Using an Intramolecular Indicator Displacement Sensing Mechanism.

Angew Chem Int Ed Engl 2018 Nov 22. Epub 2018 Nov 22.

University of Sydney, School of Chemistry, Sydney, NSW, 2006, Australia.

The detection of externalized phosphatidylserine (PS) on the cell surface is commonly used to distinguish between living, apoptotic, and necrotic cells. The tools of choice for many researchers to study apoptosis are annexin V-fluorophore conjugates. However, the use of this 35 kDa protein is associated with several drawbacks, including temperature sensitivity, Ca dependence, and slow binding kinetics. Read More

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November 2018

Harnessing the untapped potential of nucleotide-binding oligomerization domain ligands for cancer immunotherapy.

Med Res Rev 2018 Dec 13. Epub 2018 Dec 13.

University of Ljubljana, Faculty of Pharmacy, Ljubljana, Slovenia.

In the last decade, cancer immunotherapy has emerged as an effective alternative to traditional therapies such as chemotherapy and radiation. In contrast to the latter, cancer immunotherapy has the potential to distinguish between cancer and healthy cells, and thus to avoid severe and intolerable side-effects, since the cancer cells are effectively eliminated by stimulated immune cells. The cytosolic nucleotide-binding oligomerization domains 1 and 2 receptors (NOD1 and NOD2) are important components of the innate immune system and constitute interesting targets in terms of strengthening the immune response against cancer cells. Read More

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December 2018

Increasing incidence of lentigo maligna and lentigo maligna melanoma in Catalonia.

Int J Dermatol 2018 Dec 13. Epub 2018 Dec 13.

Department of Dermatology, Hospital Universitari Arnau de Vilanova, University of Lleida, IRBLleida, Lleida & CIBERONC, Lleida, Spain.

Background: Recent epidemiological studies suggest that past data where superficial spreading melanoma was by far the most common subtype of melanoma may not reflect current patterns of sun exposure or other risk factors more involved in other subtypes of melanoma as lentigo maligna (LM) or lentigo maligna melanoma (LMM).

Methods: In order to measure the current situation in our country, all cases of LM and LMM diagnosed in 23 hospitals in Catalonia, from 2000 to 2007, were recorded.

Results: Although for the global period LM/LMM represented only 8. Read More

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December 2018

Carry-over effects of early thermal conditions on somatic and germline oxidative damages are mediated by compensatory growth in sticklebacks.

J Anim Ecol 2018 Nov 22. Epub 2018 Nov 22.

Departamento de Ecoloxía e Bioloxía Animal, Universidade de Vigo, Vigo, Spain.

Most studies of climate change impacts focus on the effects of summer temperatures, which can immediately impact fitness of breeders, but winter temperatures are expected to have a greater impact on development and growth of animals with long-lasting consequences. Exposure to warmer temperatures can increase cellular oxidative damage in ectotherms. Yet, it is unknown whether thermal stress during early life has prolonged effects on oxidative status during adulthood. Read More

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November 2018

Genome sequence of Methylocystis hirsuta CSC1, a polyhydroxyalkanoate producing methanotroph.

Microbiologyopen 2018 Dec 12:e771. Epub 2018 Dec 12.

Departamento de Ingeniería Química y Tecnología del Medio Ambiente, Escuela de Ingenierías Industriales, Universidad de Valladolid, Valladolid, Spain.

Polyhydroxyalkanoates (PHAs) are biodegradable plastics that can be produced by some methanotrophic organisms such as those of the genus Methylocystis. This allows the conversion of a detrimental greenhouse gas into an environmentally friendly high added-value bioproduct. This study presents the genome sequence of Methylocystis hirsuta CSC1 (a high yield PHB producer). Read More

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December 2018

Fabrication of Kidney Proximal Tubule Grafts Using Biofunctionalized Electrospun Polymer Scaffolds.

Macromol Biosci 2018 Dec 13:e1800412. Epub 2018 Dec 13.

Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Universiteitsweg 99,, 3584, CG Utrecht, The Netherlands.

The increasing prevalence of end-stage renal disease and persistent shortage of donor organs call for alternative therapies for kidney patients. Dialysis remains an inferior treatment as clearance of large and protein-bound waste products depends on active tubular secretion. Biofabricated tissues could make a valuable contribution, but kidneys are highly intricate and multifunctional organs. Read More

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December 2018

Developing a list of invasive alien species likely to threaten biodiversity and ecosystems in the European Union.

Glob Chang Biol 2018 Dec 12. Epub 2018 Dec 12.

Environment Agency Austria, Vienna, Austria.

The European Union (EU) has recently published its first list of invasive alien species (IAS) of EU concern to which current legislation must apply. The list comprises species known to pose great threats to biodiversity and needs to be maintained and updated. Horizon scanning is seen as critical to identify the most threatening potential IAS that do not yet occur in Europe to be subsequently risk assessed for future listing. Read More

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December 2018

External validation of the PREDICT tool in Spanish women with breast cancer participating in population-based screening programmes.

J Eval Clin Pract 2018 Dec 12. Epub 2018 Dec 12.

Department of Epidemiology and Evaluation, IMIM-Hospital del Mar, Research Network on Health Services in Chronic Diseases (REDISSEC), Barcelona, Spain.

Rationale, Aims, And Objectives: To externally validate the PREDICT tool in a cohort of women participating in a population-based breast cancer screening programme who were diagnosed with breast cancer between 2000 and 2008 in Spain.

Methods: A total of 535 women were included in the validation study. We calculated predicted 5-year survival using the beta values from the development of the PREDICT model and predicted and observed events for a given risk groups. Read More

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December 2018

Data-driven adult asthma phenotypes based on clinical characteristics are associated with asthma outcomes twenty years later.

Allergy 2018 Dec 13. Epub 2018 Dec 13.

Inserm, Univ. Grenoble Alpes, CNRS, IAB, Team of environmental epidemiology applied to reproduction and respiratory health, 38000, Grenoble, France.

Background: Research based on cluster analyses led to the identification of particular phenotypes confirming phenotypic heterogeneity of asthma. The long-term clinical course of asthma phenotypes defined by clustering analysis remains unknown, although it is a key aspect to underpin their clinical relevance. We aimed to estimate risk of poor asthma events between asthma clusters identified 20 years earlier. Read More

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December 2018

A comparison of the EU regulatory approach to directed mutagenesis with that of other jurisdictions, consequences for international trade and potential steps forward.

New Phytol 2018 Dec 13. Epub 2018 Dec 13.

Biotechnology Directorate, Ministry of AgroIndustry, Buenos Aires, Argentina; National University of Quilmes, Bernal, Argentina.

A special regulatory regime applies to products of recombinant nucleic acid modifications. A ruling from the European Court of Justice has interpreted this regulatory regime in a way that it also applies to emerging mutagenesis techniques. Elsewhere regulatory progress is also ongoing. Read More

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December 2018

A systematic review of validated tools assessing functional and aesthetic outcomes following fibula free flap reconstruction of the mandible.

Head Neck 2018 Dec 12. Epub 2018 Dec 12.

Head and Neck Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.

Background: Segmental mandibulectomy impairs health-related quality of life (QoL), by altering speech, mastication, swallowing, and facial aesthetics. Fibula free flap (FFF) used for mandible reconstruction is known to improve outcomes; however, minimal information exists in the literature regarding patient-reported outcomes. We aim to assess how current studies evaluate patient perception following segmental mandibulectomy and FFF mandible reconstruction. Read More

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December 2018

Are children smoke-free at home? Using wearable cameras to study children's exposure to smoking and smoking paraphernalia in private spaces.

Child Care Health Dev 2018 Nov 22. Epub 2018 Nov 22.

Department of Public Health, University of Otago, Wellington, New Zealand.

Background: There is limited evidence available on the nature of children's exposure to smoking and smoking paraphernalia in private spaces (homes and cars). We aimed to evaluate the extent and nature of children's exposure to smoking in these settings using image data captured by wearable cameras.

Methods: One-hundred and sixty-eight children wore wearable cameras for 4 days that automatically took pictures every 7 s. Read More

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November 2018

Declining population trends of European mountain birds.

Glob Chang Biol 2018 Dec 11. Epub 2018 Dec 11.

Dachverband Deutscher Avifaunisten (DDA) e.V., Geschäftsstelle, Münster, Germany.

Mountain areas often hold special species communities, and they are high on the list of conservation concern. Global warming and changes in human land use, such as grazing pressure and afforestation, have been suggested to be major threats for biodiversity in the mountain areas, affecting species abundance and causing distribution shifts towards mountaintops. Population shifts towards poles and mountaintops have been documented in several areas, indicating that climate change is one of the key drivers of species' distribution changes. Read More

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December 2018

Relation of Left Atrial Appendage Closure Devices to Topographic Neighboring Structures using Standardized Imaging by Cardiac Computed Tomography Angiography.

Clin Cardiol 2018 Dec 11. Epub 2018 Dec 11.

First Department of Medicine, University Medical Center Mannheim (UMM), Faculty of Medicine Mannheim, University of Heidelberg, European Center for AngioScience (ECAS), and DZHK (German Center for Cardiovascular Research) partner site Heidelberg/Mannheim, Mannheim, Germany.

Background: Although left atrial appendage (LAA) anatomy and topographic relations are well understood, little is known about the impairment of neighboring structures (NBS) by an implanted left atrial appendage closure (LAAC) device. This prospective longitudinal observational study for the first time describes distances of implanted LAAC devices to NBS using a standardized imaging protocol of cardiac computed tomography angiography (cCTA).

Hypothesis: cCTA imaging is an eligible tool for post-implantation evaluation of LAAC devices and their relation to neighboring structures. Read More

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December 2018

High-pressure behaviour of Prussian blue analogues: interplay of hydration, Jahn-Teller distortions and vacancies.

Dalton Trans 2018 Dec 14. Epub 2018 Dec 14.

Department of Chemistry, University of Oxford, Inorganic Chemistry Laboratory, South Parks Road, Oxford OX1 3QR, UK.

We report a high-pressure crystallographic study of four hydrated Prussian blue analogues: M[Pt(CN)6] and M[Co(CN)6]0.67 (M = Mn2+, Cu2+) in the range 0-3 GPa. Mn[Co(CN)6]0. Read More

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December 2018

Oncologic outcomes in prostate cancer patients treated with robot-assisted radical prostatectomy: results from a single institution series with more than 10 years follow up.

Minerva Urol Nefrol 2018 Dec 14. Epub 2018 Dec 14.

Department of Urology, OLV Aalst, Belgium.

Background: Robot-assisted radical prostatectomy (RARP) has gained increasing diffusion as standard of care in the surgical treatment of prostate cancer (PCa) patients, even in the absence of robust long-term oncologic comparative data. To report oncologic outcomes of RARP at more than 10 years follow up.

Methods: We retrospectively evaluated 173 consecutive PCa patients underwent RARP between 2002 and 2005 at a single European center with complete clinic and pathologic data and potential follow up of at least 10 years. Read More

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December 2018

External validation of Imamura nomogram as a tool to predict preoperatively laser semi-rigid ureterolithotripsy outcomes.

Minerva Urol Nefrol 2018 Dec 14. Epub 2018 Dec 14.

Department of Urology, Sant'Andrea Hospital, "Sapienza" University of Rome, Rome, Italy.

Background: We aimed to validate Imamura nomogram for prediction of stone free rate in patients undergoing ureterolithotripsy.

Methods: From January 2013 to June 2016, patients undergoing laser semi-rigid ureterolithotripsy were prospectively enrolled at our centre. All patients were preoperatively assessed with clinical history, blood samples, uranalysis and non-contrast enhanced CT. Read More

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December 2018

Increased IL-1β levels are associated with an imbalance of "oxidant/antioxidant" status during Behçet's disease.

Eur Cytokine Netw 2018 Sep;29(3):95-102

USTHB, "Cytokines and NO Synthases" team, LBCM, FSB, BP 32, El Alia, 16111, Bab ezzouar, Algiers, Algeria.

Behçet's disease is a multisystem disease. It stands at the crossroad between the autoimmunity and auto-inflammatory disorders. In this study, we sought to address a relationship that might exist between interleukin-1β (IL-1β) and the oxidants/antioxidants markers in Behçet's patients. Read More

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September 2018

Neural circuitry of a polycystin-mediated hydrodynamic startle response for predator avoidance.

Elife 2018 Dec 14;7. Epub 2018 Dec 14.

Living Systems Institute, University of Exeter, Exeter, United Kingdom.

Startle responses triggered by aversive stimuli including predators are widespread across animals. These coordinated whole-body actions require the rapid and simultaneous activation of a large number of muscles. Here we study a startle response in a planktonic larva to understand the whole-body circuit implementation of the behaviour. Read More

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December 2018