4,993 results match your criteria European Journal of Nuclear Medicine and Molecular Imaging[Journal]


Functional imaging of concomitant lingual thyroid and parathyroid adenoma.

Eur J Nucl Med Mol Imaging 2019 Feb 20. Epub 2019 Feb 20.

CHU Bordeaux, Hôpital Haut-Lévêque, Service d'Endocrinologie, Diabétologie et Nutrition, 1 avenue Magellan, 33600, Pessac, France.

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http://dx.doi.org/10.1007/s00259-019-04283-xDOI Listing
February 2019

Clinical value of FDG-PET/CT in bacteremia of unknown origin with catalase-negative gram-positive cocci or Staphylococcus aureus.

Eur J Nucl Med Mol Imaging 2019 Feb 20. Epub 2019 Feb 20.

Department of Nuclear Medicine, Odense University Hospital, Sdr. Boulevard 29, Indgang 44, 46, 5000, Odense C, Denmark.

Introduction: Bacteremia is associated with high mortality, especially when the site of infection is unknown. While conventional imaging usually focus on specific body parts, FDG-PET/CT visualizes hypermetabolic foci throughout the body.

Purpose: To investigate the ability of FDG/PET-CT to detect the site of infection and its clinical impact in bacteremia of unknown origin with catalase-negative Gram-positive cocci (excluding pneumococci and enterococci) or Staphylococcus aureus (BUOCSA). Read More

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http://dx.doi.org/10.1007/s00259-019-04289-5DOI Listing
February 2019

F-FDG PET/CT in multiple myeloma: critical insights and future directions.

Eur J Nucl Med Mol Imaging 2019 Feb 15. Epub 2019 Feb 15.

CRCINA, INSERM, CNRS, Université d'Angers, Université de Nantes, Nantes, France.

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http://dx.doi.org/10.1007/s00259-019-04279-7DOI Listing
February 2019
1 Read

Correction to: Digital vs. analog PET/CT: intra-subject comparison of the SUVmax in target lesions and reference regions.

Eur J Nucl Med Mol Imaging 2019 Feb 9. Epub 2019 Feb 9.

Nuclear Medicine Department, Hospital Sant Pau, Autonomous University of Barcelona, Sant Antoni M. Claret, 167, 08025, Barcelona, Spain.

The article Digital vs. analog PET/CT: intra-subject comparison of the SUVmax in target lesions and reference regions, written by Francisco Fuentes-Ocampo, Diego Alfonso López-Mora, Albert Flotats, Gabriela Paillahueque. Read More

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http://dx.doi.org/10.1007/s00259-019-04280-0DOI Listing
February 2019

Correction to: Consensus document for the diagnosis of prosthetic joint infections: a joint paper by the EANM, EBJIS, and ESR (with ESCMID endorsement).

Eur J Nucl Med Mol Imaging 2019 Feb 9. Epub 2019 Feb 9.

Department of Orthopaedic Surgery, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

The authors regret to inform the readers that one of the author's name in the original publication of this article was spelled incorrectly as Victor Casar-Pullicino. The correct spelling is Victor N. Cassar-Pullicino and is now presented correctly in this article. Read More

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http://dx.doi.org/10.1007/s00259-019-04281-zDOI Listing
February 2019

Chemoradiotherapy for locally advanced cervix cancer without aortic lymph node involvement: can we consider metabolic parameters of pretherapeutic FDG-PET/CT for treatment tailoring?

Eur J Nucl Med Mol Imaging 2019 Feb 7. Epub 2019 Feb 7.

Department of Surgical Oncology, IUCT-Oncopole, 1 avenue Irène Joliot-Curie, 31059, Toulouse Cedex 9, France.

Purpose: Aim of the study was to assess impact of pretherapeutic FDG-PET/CT metabolic parameters on response to chemoradiotherapy (CRT) and survival in locally advanced cervical cancer (LACC) patients without paraaortic lymph node involvement.

Methods: LACC patients treated with CRT without macrometastatic involvement after paraaortic surgical staging were included. All patients had received at least 45 Gy radiotherapy and five cycles of platinum-based chemotherapy. Read More

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http://dx.doi.org/10.1007/s00259-018-4219-5DOI Listing
February 2019
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Preliminary results of the Phase 1 Lip-Re I clinical trial: biodistribution and dosimetry assessments in hepatocellular carcinoma patients treated with Re-SSS Lipiodol radioembolization.

Eur J Nucl Med Mol Imaging 2019 Feb 4. Epub 2019 Feb 4.

Department of Nuclear Medicine, Cancer Institute Eugène Marquis, Avenue de la Bataille Flandres-Dunkerque, CS 44229, 35042, Rennes, cedex, France.

Purpose: This study sought to provide preliminary results on the biodistribution and dosimetry following intra-arterial liver injection of Re-SSS Lipiodol on hepatocellular carcinoma patients included in the Phase I Lip-Re 1 study.

Methods: Results of the first six patients included are reported. Analysis of the Re-SSS Lipiodol biodistribution was based on planar scintigraphic and tomoscintigraphic (SPECT) studies performed at 1, 6, 24, 48, and 72 h post-administration. Read More

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http://dx.doi.org/10.1007/s00259-019-04277-9DOI Listing
February 2019
2 Reads

Pretreatment metabolic tumour volume in stage IIIA/B non-small-cell lung cancer uncovers differences in effectiveness of definitive radiochemotherapy schedules: analysis of the ESPATUE randomized phase 3 trial.

Eur J Nucl Med Mol Imaging 2019 Feb 1. Epub 2019 Feb 1.

Department of Radiation Oncology, West German Cancer Center, University of Duisburg-Essen Medical School, Hufelandstr. 55, 45122, Essen, Germany.

Purpose: According to the ACRIN 6668/RTOG 0235 trial, pretreatment metabolic tumour volume (MTV) as detected by F-fluorodeoxyglucose PET/CT is a prognostic factor in patients with stage III non-small-cell lung cancer (NSCLC) after definitive radiochemotherapy (RCT). To validate the prognostic value of MTV in patients with stage III NSCLC after RCT, we analysed mature survival data from the German phase III trial ESPATUE.

Methods: This analysis included patients who were staged by PET/CT and who were enrolled in the ESPATUE trial, a randomized study comparing definitive RCT (arm A) with surgery (arm B) after induction chemotherapy and RCT in patients with resectable stage IIIA/IIIB NSCLC. Read More

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http://dx.doi.org/10.1007/s00259-019-4270-xDOI Listing
February 2019

Ga-PSMA PET/CT for monitoring response to Lu-PSMA-617 radioligand therapy in patients with metastatic castration-resistant prostate cancer.

Eur J Nucl Med Mol Imaging 2019 Jan 29. Epub 2019 Jan 29.

Department of Nuclear Medicine, University Hospital Bonn, Bonn, Germany.

Purpose: To evaluate the use of Ga-PSMA PET/CT for monitoring response to Lu-617 PSMA radioligand therapy in patients with metastatic castrate-resistant prostate cancer (mCRPC).

Methods: Patients from the University Hospital Bonn and the University Hospital Aachen were retrospectively reviewed for this study. We included 48 patients with mCRPC who were treated with Lu-PSMA-617 and whose records included Ga-PSMA PET/CT imaging before the first and after the third or fourth treatment cycle. Read More

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http://dx.doi.org/10.1007/s00259-019-4258-6DOI Listing
January 2019

Imaging of tau deposits in adults with Niemann-Pick type C disease: a case-control study.

Eur J Nucl Med Mol Imaging 2019 Jan 28. Epub 2019 Jan 28.

The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, VIC, Australia.

Purpose: Niemann-Pick type C (NPC) is a cholesterol storage disease characterized by disruption in the endosomal-lysosomal transport system that leads to the accumulation of cholesterol and glycolipids in lysosomes. Developmental cognitive delay and progressive motor and cognitive impairment are characteristic of the disease. Tau accumulation has been reported in some NPC patients. Read More

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http://dx.doi.org/10.1007/s00259-019-4273-7DOI Listing
January 2019
1 Read

Economic sanctions are against basic human rights on health.

Eur J Nucl Med Mol Imaging 2019 Jan 28. Epub 2019 Jan 28.

Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1007/s00259-019-4269-3DOI Listing
January 2019

Pretreatment F-FDG PET/CT combined with quantification of clonal circulating plasma cells as a potential risk model in patients with newly diagnosed multiple myeloma.

Eur J Nucl Med Mol Imaging 2019 Jan 28. Epub 2019 Jan 28.

Division of Haematology/Oncology, Department of Internal Medicine, Kameda Medical Centre, 929 Higashi-chou, Kamogawa, 296-8602, Japan.

Purpose: Both F-FDG PET/CT and clonal circulating plasma cell (CPC) quantification are emerging tools for multiple myeloma (MM) prognostication that have been validated in recent studies. This study investigated the value of PET/CT coupled with CPC quantification for MM prognostication that may contribute to future risk-adapted treatment.

Methods: We retrospectively analysed the prognostic relevance of a combination of pretreatment PET/CT findings and CPC levels in 163 consecutive patients with newly diagnosed, symptomatic MM receiving novel agents during induction therapies. Read More

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http://dx.doi.org/10.1007/s00259-019-4275-5DOI Listing
January 2019

The mean striatal F-DOPA uptake is not a reliable cut-off threshold for biological tumour volume definition of glioma.

Eur J Nucl Med Mol Imaging 2019 Jan 26. Epub 2019 Jan 26.

Nuclear Medicine, Sant'Andrea Hospital, Department of Surgical and Medical Sciences and Translational Medicine, Faculty of Medicine and Psychology, Sapienza University of Rome, Rome, Italy.

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http://dx.doi.org/10.1007/s00259-019-4276-4DOI Listing
January 2019

Consensus document for the diagnosis of prosthetic joint infections: a joint paper by the EANM, EBJIS, and ESR (with ESCMID endorsement).

Eur J Nucl Med Mol Imaging 2019 Jan 26. Epub 2019 Jan 26.

Department of Orthopaedic Surgery, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Background: For the diagnosis of prosthetic joint infection, real evidence-based guidelines to aid clinicians in choosing the most accurate diagnostic strategy are lacking.

Aim And Methods: To address this need, we performed a multidisciplinary systematic review of relevant nuclear medicine, radiological, orthopaedic, infectious, and microbiological literature to define the diagnostic accuracy of each diagnostic technique and to address and provide evidence-based answers on uniform statements for each topic that was found to be important to develop a commonly agreed upon diagnostic flowchart.

Results And Conclusion: The approach used to prepare this set of multidisciplinary guidelines was to define statements of interest and follow the procedure indicated by the Oxford Centre for Evidence-based Medicine (OCEBM). Read More

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http://dx.doi.org/10.1007/s00259-019-4263-9DOI Listing
January 2019
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FDG atrial uptake is associated with an increased prevalence of stroke in patients with atrial fibrillation.

Eur J Nucl Med Mol Imaging 2019 Jan 25. Epub 2019 Jan 25.

Nuclear Medicine Department, Bichat-Claude Bernard Hospital, AP-HP, Paris, France.

Purpose: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and is associated with an increased risk of stroke. Indeed, silent AF is frequently identified in unexplained ischemic stroke. F-FDG-PET/CT is a powerful tool for assessing myocardial metabolic shift and inflammation, both potentially at stake in AF. Read More

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http://dx.doi.org/10.1007/s00259-019-4274-6DOI Listing
January 2019

Post-radiotherapy PET/CT for predicting treatment outcomes in head and neck cancer after postoperative radiotherapy.

Eur J Nucl Med Mol Imaging 2019 Jan 24. Epub 2019 Jan 24.

Department of Radiation Oncology, Case Western Reserve University and University Hospitals, Cleveland, OH, USA.

Purpose: The purpose of this study was to retrospectively review the role of post-treatment (post-tx) FDG-PET/CT scans in patients receiving postoperative intensity-modulated radiotherapy (IMRT) for head and neck squamous cell carcinomas (HNSCC).

Materials And Methods: Eighty-two patients with HNSCC treated with surgery and postoperative IMRT with or without chemotherapy from October 15, 2008 to December 31, 2014 that had post-tx PET/CT within 6 months of completing IMRT were included. PET/CT was considered positive based on multi-disciplinary review integrating clinical information. Read More

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http://dx.doi.org/10.1007/s00259-019-4272-8DOI Listing
January 2019
1 Read

Consensus document for the diagnosis of peripheral bone infection in adults: a joint paper by the EANM, EBJIS, and ESR (with ESCMID endorsement).

Eur J Nucl Med Mol Imaging 2019 Jan 24. Epub 2019 Jan 24.

Unit of Diagnostic and Interventional Radiology, IRCCS Istituto Ortopedico Galeazzi, Milan, Italy.

Introduction: In adults with a suspicion of peripheral bone infection, evidence-based guidelines in choosing the most accurate diagnostic strategy are lacking.

Aim And Methods: To provide an evidence-based, multidisciplinary consensus document on the diagnostic management of adult patients with PBIs, we performed a systematic review of relevant infectious, microbiological, orthopedic, radiological, and nuclear medicine literature. Delegates from four European societies (European Bone and Joint Infection Society, European Society of Microbiology and Infectious Diseases, European Society or Radiology, and European Association of Nuclear Medicine) defined clinical questions to be addressed, thoroughly reviewed the literature pertinent to each of the questions, and thereby evaluated the diagnostic accuracy of each diagnostic technique. Read More

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http://link.springer.com/10.1007/s00259-019-4262-x
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http://dx.doi.org/10.1007/s00259-019-4262-xDOI Listing
January 2019
6 Reads

Bronchial inflammatory granulation after endobronchial ultrasound-guided transbronchial needle aspiration and immunotherapy.

Eur J Nucl Med Mol Imaging 2019 Jan 21. Epub 2019 Jan 21.

Department of Nuclear Medicine, Shanghai Pulmonary Hospital, Tongji University School of Medicine, 507 Zhengmin Road, Shanghai, 200433, China.

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http://dx.doi.org/10.1007/s00259-019-4266-6DOI Listing
January 2019

The validity of F-GE180 as a TSPO imaging agent.

Eur J Nucl Med Mol Imaging 2019 Jan 17. Epub 2019 Jan 17.

Nantz National Alzheimer Center and Houston Methodist Research Institute, 6670 Bertner Ave, Houston, TX, 77030, USA.

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http://link.springer.com/10.1007/s00259-019-4268-4
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http://dx.doi.org/10.1007/s00259-019-4268-4DOI Listing
January 2019
2 Reads

Heart rate reserve during pharmacological stress is a significant negative predictor of impaired coronary flow reserve in women.

Eur J Nucl Med Mol Imaging 2019 Jan 16. Epub 2019 Jan 16.

Department of Nuclear Medicine, University Hospital Zurich, Raemistrasse 100, 8091, Zurich, Switzerland.

Purpose: Evidence to date has failed to adequately explore determinants of cardiovascular risk in women with coronary microvascular dysfunction (CMVD). Heart rate responses to adenosine mirror autonomic activity and may carry important prognostic information for the diagnosis of CMVD.

Methods: Hemodynamic changes during adenosine stress were analyzed in a propensity-matched cohort of 404 patients (202 women, mean age 65. Read More

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http://dx.doi.org/10.1007/s00259-019-4265-7DOI Listing
January 2019
1 Read

Prediction of biological characteristics of breast cancer using dual-phase FDG PET/CT.

Eur J Nucl Med Mol Imaging 2019 Jan 16. Epub 2019 Jan 16.

Department of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, 1-2-3 Kasumi, Minami-Ku, Hiroshima City, Hiroshima, 734-8551, Japan.

Purpose: The aim of this study was to assess whether the retention index (RI) determined using dual-phase F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) reflects the malignant features of breast cancer.

Methods: A total of 1,523 patients with breast cancer were retrospectively evaluated. PET/CT scans were performed at 1 h and 2 h after FDG administration before treatment. Read More

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http://dx.doi.org/10.1007/s00259-019-4259-5DOI Listing
January 2019
2 Reads

Predicting locally advanced rectal cancer response to neoadjuvant therapy with F-FDG PET and MRI radiomics features.

Eur J Nucl Med Mol Imaging 2019 Jan 13. Epub 2019 Jan 13.

Imaging Unit, Candiolo Cancer Institute, FPO-IRCCS, Strada Provinciale 142 km 3.95, 10060, Candiolo, TO, Italy.

Purpose: Pathological complete response (pCR) following neoadjuvant chemoradiotherapy or radiotherapy in locally advanced rectal cancer (LARC) is reached in approximately 15-30% of cases, therefore it would be useful to assess if pretreatment of F-FDG PET/CT and/or MRI texture features can reliably predict response to neoadjuvant therapy in LARC.

Methods: Fifty-two patients were dichotomized as responder (pR+) or non-responder (pR-) according to their pathological tumor regression grade (TRG) as follows: 22 as pR+ (nine with TRG = 1, 13 with TRG = 2) and 30 as pR- (16 with TRG = 3, 13 with TRG = 4 and 1 with TRG = 5). First-order parameters and 21 second-order texture parameters derived from the Gray-Level Co-Occurrence matrix were extracted from semi-automatically segmented tumors on T2w MRI, ADC maps, and PET/CT acquisitions. Read More

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http://dx.doi.org/10.1007/s00259-018-4250-6DOI Listing
January 2019
1 Read

Interim analysis of the REASSURE (Radium-223 alpha Emitter Agent in non-intervention Safety Study in mCRPC popUlation for long-teRm Evaluation) study: patient characteristics and safety according to prior use of chemotherapy in routine clinical practice.

Eur J Nucl Med Mol Imaging 2019 Jan 12. Epub 2019 Jan 12.

Royal Marsden Hospital, London, UK.

Purpose: REASSURE is a global, prospective, non-interventional study to assess long-term safety of radium-223 in patients with bone metastatic castration-resistant prostate cancer. Here we report an interim analysis of patients according to previous use of chemotherapy.

Methods: Radium-223 was administered in routine clinical practice. Read More

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http://link.springer.com/10.1007/s00259-019-4261-y
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http://dx.doi.org/10.1007/s00259-019-4261-yDOI Listing
January 2019
8 Reads

Diagnostic manifestations of total hemispheric glucose metabolism ratio in neuronal network diaschisis: diagnostic implications in Alzheimer's disease and mild cognitive impairment.

Eur J Nucl Med Mol Imaging 2019 Jan 12. Epub 2019 Jan 12.

Department of Nuclear Medicine, Odense University Hospital, Odense, Denmark.

Purpose: We tested the hypothesis that lateralized hemispheric glucose metabolism may have diagnostic implications in Alzheimer's disease (AD) and mild cognitive impairment (MCI).

Methods: We performed FDG-PET/CT in 23 patients (mean age 63.7 years, range 50-78, 17 females) diagnosed with AD (n = 15) or MCI (n = 8) during a six-month period in 2014. Read More

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http://dx.doi.org/10.1007/s00259-018-4248-0DOI Listing
January 2019
6 Reads
5.383 Impact Factor

Tiger man sign in sarcoid myopathy.

Eur J Nucl Med Mol Imaging 2019 Jan 12. Epub 2019 Jan 12.

Department of Nuclear Medicine, University Hospital Würzburg, Oberdürrbacher Straße 6, 97080, Würzburg, Germany.

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http://dx.doi.org/10.1007/s00259-019-4264-8DOI Listing
January 2019
1 Read

The evolving Editorial Board.

Authors:
Arturo Chiti

Eur J Nucl Med Mol Imaging 2019 03;46(3):539

Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, 20090, Pieve Emanuele, Milan, Italy.

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http://dx.doi.org/10.1007/s00259-019-4267-5DOI Listing
March 2019
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Diagnostic performance of Ga-PSMA PET/CT in the detection of prostate cancer prior to initial biopsy: comparison with cancer-predicting nomograms.

Eur J Nucl Med Mol Imaging 2019 Jan 11. Epub 2019 Jan 11.

Department of Nuclear Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.

Purpose: To assess the diagnostic performance of Ga-PSMA PET/CT for detecting suspected prostate cancer (PCa) and to compare it with that of two cancer-predicting nomograms.

Methods: We performed a retrospective analysis of 146 consecutive patients with suspected PCa based on symptoms or elevated total prostate-specific antigen (tPSA) levels who underwent Ga-PSMA PET/CT and histopathologic examinations from April 2017 to April 2018 in a large tertiary care hospital in China. The Ga-PSMA PET/CT results (PCa or benignancy) were evaluated by two experienced nuclear medicine specialists. Read More

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http://link.springer.com/10.1007/s00259-018-4255-1
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http://dx.doi.org/10.1007/s00259-018-4255-1DOI Listing
January 2019
7 Reads

Prospective comparison of (4S)-4-(3-F-fluoropropyl)-L-glutamate versus F-fluorodeoxyglucose PET/CT for detecting metastases from pancreatic ductal adenocarcinoma: a proof-of-concept study.

Eur J Nucl Med Mol Imaging 2019 Jan 11. Epub 2019 Jan 11.

Department of Surgery, National Taiwan University Hospital and National Taiwan University College of Medicine, 7 Chung-Shan South Rd., Taipei, 10002, Taiwan, Republic of China.

Purpose: (4S)-4-(3-F-Fluoropropyl)-L-glutamate (FSPG) positron emission tomography (PET) reflects system x transporter (xCT) expression. FSPG PET has been used to detect brain, lung, breast and liver cancer with only modest success. There is no report on the use of FSPG PET in pancreatic ductal adenocarcinoma (PDAC), presumably because of normal xCT expression in the pancreas. Read More

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http://dx.doi.org/10.1007/s00259-018-4251-5DOI Listing
January 2019
3 Reads

C-choline PET/CT predicts survival in prostate cancer patients with PSA < 1 NG/ml.

Eur J Nucl Med Mol Imaging 2019 Jan 10. Epub 2019 Jan 10.

Department of Nuclear Medicine, IRCCS San Raffaele Scientific Institute, Milan, Italy.

Purpose: The main drawback of C-choline PET/CT for restaging prostate cancer (PCa) patients with biochemical failure is the relatively low positive detection rate for prostate specific antigen (PSA) < 1 ng/ml. This study assessed whether C-choline PET/CT predicts survival in PCa patients with PSA < 1 ng/ml.

Methods: This retrospective study included 210 PCa patients treated with radical prostatectomy who underwent C-choline PET/CT from December 1, 2004 to July 31, 2007 due to biochemical failure. Read More

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http://dx.doi.org/10.1007/s00259-018-4253-3DOI Listing
January 2019
1 Read

Comparison of image quality and lesion detection between digital and analog PET/CT.

Eur J Nucl Med Mol Imaging 2019 Jan 10. Epub 2019 Jan 10.

Nuclear Medicine Department, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Pare Claret 167, 08025, Barcelona, Spain.

Objective: The purpose of this study was to compare image quality and lesion detection capability between a digital and an analog PET/CT system in oncological patients.

Materials And Methods: One hundred oncological patients (62 men, 38 women; mean age of 65 ± 12 years) were prospectively included from January-June 2018. All patients, who accepted to be scanned by two systems, consecutively underwent a single day, dual imaging protocol (digital and analog PET/CT). Read More

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http://dx.doi.org/10.1007/s00259-019-4260-zDOI Listing
January 2019
1 Read

Sex differences in [C]ABP688 binding: a positron emission tomography study of mGlu5 receptors.

Eur J Nucl Med Mol Imaging 2019 Jan 9. Epub 2019 Jan 9.

Department of Psychiatry, McGill University, 1033 Pine Avenue West, Montreal, QC, H3A 1A1, Canada.

Purpose: The purpose of this study was to assess, in a large sample of healthy young adults, sex differences in the binding potential of [C]ABP688, a positron emission tomography (PET) tracer selective for the metabotropic glutamate type 5 (mGlu5) receptor.

Methods: High resolution [C]ABP688 PET scans were acquired in 74 healthy volunteers (25 male, 49 female, mean age 20 ± 3.0). Read More

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http://link.springer.com/10.1007/s00259-018-4252-4
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http://dx.doi.org/10.1007/s00259-018-4252-4DOI Listing
January 2019
4 Reads

Cortical atrophic-hypometabolic dissociation in the transition from premanifest to early-stage Huntington's disease.

Eur J Nucl Med Mol Imaging 2019 Jan 9. Epub 2019 Jan 9.

Movement Disorders Unit, Neurology Department, Hospital de la Santa Creu i Sant Pau, Mas Casanovas 90, 08041, Barcelona, Spain.

Purpose: Huntington's disease (HD) is a fatal neurodegenerative disorder with no effective treatment currently available. Although the pathological hallmark of HD is massive striatal atrophy, it has been suggested that cortical deterioration may concomitantly occur and play a major role in the patient's functional independence. Our objective was to characterize cortical structural and metabolic neurodegeneration in the transition from premanifest to early-stage Huntington's disease (HD). Read More

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http://dx.doi.org/10.1007/s00259-018-4257-zDOI Listing
January 2019
2 Reads

Relationship between the expression of PD-1/PD-L1 and F-FDG uptake in bladder cancer.

Eur J Nucl Med Mol Imaging 2019 Jan 9. Epub 2019 Jan 9.

Department of Nuclear Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Purpose: Immunotherapy aimed at inhibiting the PD-1/PD-L1 immune checkpoint has been approved and used successfully for the treatment of bladder cancer. The identification of markers predictive of response to immune checkpoint inhibitors is critical to advancing the success of this therapy. F-FDG PET/CT is a molecular imaging technique that can provide phenotypic information on malignant tumours. Read More

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http://link.springer.com/10.1007/s00259-018-4208-8
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http://dx.doi.org/10.1007/s00259-018-4208-8DOI Listing
January 2019
7 Reads

Obligatory role of endoplasmic reticulum in brain FDG uptake.

Eur J Nucl Med Mol Imaging 2019 Jan 8. Epub 2019 Jan 8.

Nuclear Medicine, IRCCS Ospedale Policlinico San Martino, Largo Rosanna Benzi 10, 16132, Genoa, Italy.

Purpose: The endoplasmic reticulum (ER) contains hexose-6P-dehydrogenase (H6PD). This enzyme competes with glucose-6P-phosphatase for processing a variety of phosphorylated hexoses including 2DG-6P. The present study aimed to verify whether this ER glucose-processing machinery contributes to brain FDG uptake. Read More

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http://dx.doi.org/10.1007/s00259-018-4254-2DOI Listing
January 2019
2 Reads
5.383 Impact Factor

Tauopathy in veterans with long-term posttraumatic stress disorder and traumatic brain injury.

Eur J Nucl Med Mol Imaging 2019 Jan 7. Epub 2019 Jan 7.

Queensland Brain Institute, University of Queensland, Building 79, Upland Road, Saint Lucia, Brisbane, Queensland, 4072, Australia.

Purpose: Traumatic brain injury (TBI) and posttraumatic stress disorder (PTSD) have emerged as independent risk factors for an earlier onset of Alzheimer's disease (AD), although the pathophysiology underlying this risk is unclear. Postmortem studies have revealed extensive cerebral accumulation of tau following multiple and single TBI incidents. We hypothesized that a history of TBI and/or PTSD may induce an AD-like pattern of tau accumulation in the brain of nondemented war veterans. Read More

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http://dx.doi.org/10.1007/s00259-018-4241-7DOI Listing
January 2019
2 Reads

Testing the diagnostic accuracy of [18F]FDG-PET in discriminating spinal- and bulbar-onset amyotrophic lateral sclerosis.

Eur J Nucl Med Mol Imaging 2019 Jan 7. Epub 2019 Jan 7.

Vita-Salute San Raffaele University, Milan, Italy.

Purpose: The role for [18F]FDG-PET in supporting amyotrophic lateral sclerosis (ALS) diagnosis is not fully established. In this study, we aim at evaluating [18F]FDG-PET hypo- and hyper-metabolism patterns in spinal- and bulbar-onset ALS cases, at the single-subject level, testing the diagnostic value in discriminating the two conditions, and the correlations with core clinical symptoms severity.

Methods: We included 95 probable-ALS patients with [18F]FDG-PET scan and clinical follow-up. Read More

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http://link.springer.com/10.1007/s00259-018-4246-2
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http://dx.doi.org/10.1007/s00259-018-4246-2DOI Listing
January 2019
3 Reads

An unusual altered biodistribution of F-FDG on PET/CT: diffuse perimuscular uptake in the setting of acute adrenal crisis.

Eur J Nucl Med Mol Imaging 2019 Jan 7. Epub 2019 Jan 7.

Department of Radiology, Nuclear Medicine Section, University of Minnesota, Minneapolis, MN, USA.

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http://dx.doi.org/10.1007/s00259-018-4247-1DOI Listing
January 2019
2 Reads

Early F-FDOPA PET/CT imaging after carbidopa premedication as a valuable diagnostic option in patients with insulinoma.

Eur J Nucl Med Mol Imaging 2019 03 7;46(3):686-695. Epub 2019 Jan 7.

Biophysics and Nuclear Medicine, University Hospitals of Strasbourg, Strasbourg, France.

Purpose: Data on the diagnostic value of F-FDOPA PET/CT in patients with insulinoma are limited and are focused on small patient populations explored using different PET/CT protocols and the inconsistent use of carbidopa premedication. The aim of this study was to improve the current knowledge about the diagnostic value of F-FDOPA PET/CT combined with oral carbidopa premedication and early pancreatic imaging for tumour localization in patients with insulinoma-related hyperinsulinaemic hypoglycaemia (HH). The relationships among F-FDOPA quantitative uptake parameters, insulin secretion and tumour pathological features were also investigated. Read More

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http://dx.doi.org/10.1007/s00259-018-4245-3DOI Listing
March 2019
3 Reads

Digital vs. analog PET/CT: intra-subject comparison of the SUVmax in target lesions and reference regions.

Eur J Nucl Med Mol Imaging 2019 Jan 7. Epub 2019 Jan 7.

Nuclear Medicine Department, Hospital Sant Pau, Autonomous University of Barcelona, Sant Antoni M. Claret, 167, 08025, Barcelona, Spain.

Purpose: The purpose of this study was to assess whether digital photon counting technology in digital PET/CT influences the quantification of SUVmax in target lesions and regions of reference compared to analog PET/CT before an interchangeable use of either system in follow up studies.

Methods: From January to June of 2018, 100 oncological patients underwent successive PET/CT imaging with digital and analog systems in the same day. Fifty-eight patients underwent analog imaging first and digital imaging thereafter, and 42 patients the other way round. Read More

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http://dx.doi.org/10.1007/s00259-018-4256-0DOI Listing
January 2019
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Impact of Ga-68-PSMA PET/CT on management in prostate cancer patients with very early biochemical recurrence after radical prostatectomy.

Eur J Nucl Med Mol Imaging 2019 Jan 8. Epub 2019 Jan 8.

Division of Radiotherapy and Imaging, Centre for Cancer Imaging/SRD, The Institute of Cancer Research, 15 Cotswold Road, London, Sutton, SM2 5NG, UK.

Purpose: With the availability of ultra-sensitive PSA assays, early biochemical relapse (eBCR) of prostate cancer is increasingly being detected at values much lower than the conventional threshold of 0.2 ng/ml. Accurate localisation of disease in this setting may allow treatment modification and improved outcomes, especially in patients with pelvis-confined or extra-pelvic oligometastasis (defined as up to three pelvic nodal or distant sites). Read More

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http://dx.doi.org/10.1007/s00259-018-4249-zDOI Listing
January 2019
1 Read

F-DOPA PET/CT in brain tumors: impact on multidisciplinary brain tumor board decisions.

Eur J Nucl Med Mol Imaging 2019 03 5;46(3):558-568. Epub 2019 Jan 5.

Department of Nuclear Medicine, Centre Antoine-Lacassagne, Université Côte d'Azur (UCA), 33 Avenue de Valombrose, 06100, Nice, France.

Purpose: This study aimed to assess the therapeutic impact and diagnostic accuracy of F-DOPA PET/CT in patients with glioblastoma or brain metastases.

Methods: Patients with histologically proven glioblastoma or brain metastases were prospectively included in this monocentric clinical trial (IMOTEP). Patients were included either due to a clinical suspicion of relapse or to assess residual tumor infiltration after treatment. Read More

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http://dx.doi.org/10.1007/s00259-018-4240-8DOI Listing
March 2019
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Longitudinal tau and metabolic PET imaging in relation to novel CSF tau measures in Alzheimer's disease.

Eur J Nucl Med Mol Imaging 2019 Jan 4. Epub 2019 Jan 4.

Department of Neurobiology, Care Sciences and Society, Division of Clinical Geriatrics, Karolinska Institutet, Stockholm, Sweden.

Purpose: Studies comparing CSF and PET tau biomarkers have included only commercial CSF assays examining specific phosphorylation sites (e.g. threonine 181, P-tau) and mid-domain tau (i. Read More

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http://dx.doi.org/10.1007/s00259-018-4242-6DOI Listing
January 2019
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Effect of (Z)-isomer content on [C]ABP688 binding potential in humans.

Eur J Nucl Med Mol Imaging 2019 Jan 3. Epub 2019 Jan 3.

Department of Psychiatry, McGill University, 1033 Pine Avenue West, Montreal, QC, H3A 1A1, Canada.

Purpose: To determine how the low-affinity (Z)-isomer of the radiotracer [C]ABP688 affects binding potential values in vivo in humans.

Methods: High-resolution [C]ABP688 PET scans were acquired on 74 healthy volunteers (25 male, 49 female, mean age 20 ± 3.0). Read More

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http://link.springer.com/10.1007/s00259-018-4237-3
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http://dx.doi.org/10.1007/s00259-018-4237-3DOI Listing
January 2019
2 Reads

Development and dosimetry of Pb/Pb-labelled PSMA ligands: bringing "the lead" into PSMA-targeted alpha therapy?

Eur J Nucl Med Mol Imaging 2019 Jan 3. Epub 2019 Jan 3.

Department of Nuclear Medicine, University Hospital Heidelberg, INF 400, 69120, Heidelberg, Germany.

Purpose: The aims of this study were to develop a prostate-specific membrane antigen (PSMA) ligand for labelling with different radioisotopes of lead and to obtain an approximation of the dosimetry of a simulated Pb-based alpha therapy using its Pb imaging analogue.

Methods: Four novel Glu-urea-based ligands containing the chelators p-SCN-Bn-TCMC or DO3AM were synthesized. Affinity and PSMA-specific internalization were studied in C4-2 cells, and biodistribution in C4-2 tumour-bearing mice. Read More

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http://link.springer.com/10.1007/s00259-018-4220-z
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http://dx.doi.org/10.1007/s00259-018-4220-zDOI Listing
January 2019
3 Reads

Bloodpool SPECT as part of bone SPECT/CT in painful total knee arthroplasty (TKA): validation and potential biomarker of prosthesis biomechanics.

Eur J Nucl Med Mol Imaging 2019 Jan 2. Epub 2019 Jan 2.

Department of Nuclear Medicine, Antwerp University Hospital, Wilrijkstraat 10, 2650, Edegem, Belgium.

Purpose: To compare bloodpool SPECT with planar imaging in bone SPECT/CT of painful total knee arthroplasty (TKA) with respect to inter-rater agreement, confidence, prosthesis outcome, and biomechanical functioning.

Methods: Retrospective study of bloodpool SPECT and planar control images. Four raters used the validated Bruderholz scheme and a 5-point scale to grade uptake. Read More

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http://dx.doi.org/10.1007/s00259-018-4244-4DOI Listing
January 2019
3 Reads

Pitfalls in Ga-68-PSMA-PET/CT: incidental finding of parathyroid adenoma.

Eur J Nucl Med Mol Imaging 2018 Dec 19. Epub 2018 Dec 19.

Department of Nuclear Medicine, Technische Universität München, Klinikum rechts der Isar, Ismaninger Strasse 22, 81675, Munich, Germany.

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http://dx.doi.org/10.1007/s00259-018-4239-1DOI Listing
December 2018
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Dual-phase [18F]florbetapir in frontotemporal dementia.

Eur J Nucl Med Mol Imaging 2019 02 19;46(2):304-311. Epub 2018 Dec 19.

Wolfson Molecular Imaging Centre, Faculty of Medicine, Biology and Health, University of Manchester, 27 Palatine Road, Manchester, M20 3LJ, UK.

Purpose: The PET tracer [18F]florbetapir is a specific fibrillar amyloid-beta (Aβ) biomarker. During the late scan phase (> 40 min), it provides pathological information about Aβ status. Early scan phase (0-10 min) can provide FDG-'like' information. Read More

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http://dx.doi.org/10.1007/s00259-018-4238-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333719PMC
February 2019
6 Reads

Response assessment using Ga-PSMA ligand PET in patients undergoing Lu-PSMA radioligand therapy for metastatic castration-resistant prostate cancer.

Eur J Nucl Med Mol Imaging 2018 Dec 19. Epub 2018 Dec 19.

Working Group of Diagnostic Imaging in Urology, Austrian Society of Urology, Vienna, Austria.

Purpose: The first aim of this study was to evaluate Ga-PSMA conjugate 11 positron emission tomography (PSMA PET) parameters for assessment of response to Lu-PSMA-617 radioligand therapy (RLT) in patients with metastatic castration-resistant prostate cancer (mCRPC). The second aim was to investigate factors associated with overall survival (OS).

Methods: We retrospectively assessed mean standardized uptake values (SUVmean) and total tumor volumes (TTV) on PSMA PET in 38 of 55 mCRPC patients before and after RLT. Read More

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http://dx.doi.org/10.1007/s00259-018-4236-4DOI Listing
December 2018
2 Reads

The EANM practical guidelines for sentinel lymph node localisation in oral cavity squamous cell carcinoma.

Eur J Nucl Med Mol Imaging 2019 03 18;46(3):623-637. Epub 2018 Dec 18.

University Hospital San Pedro and Centre for Biomedical Research of La Rioja (CIBIR), Logroño, La Rioja, Spain.

Purpose: Sentinel lymph node biopsy is an essential staging tool in patients with clinically localized oral cavity squamous cell carcinoma. The harvesting of a sentinel lymph node entails a sequence of procedures with participation of specialists in nuclear medicine, radiology, surgery, and pathology. The aim of this document is to provide guidelines for nuclear medicine physicians performing lymphoscintigraphy for sentinel lymph node detection in patients with early N0 oral cavity squamous cell carcinoma. Read More

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http://link.springer.com/10.1007/s00259-018-4235-5
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http://dx.doi.org/10.1007/s00259-018-4235-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351508PMC
March 2019
12 Reads
5.383 Impact Factor

The good rays: let them shine!

Eur J Nucl Med Mol Imaging 2019 02 17;46(2):271-275. Epub 2018 Dec 17.

Department of Nuclear Medicine, Odense University Hospital, 5000, Odense C, Denmark.

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http://dx.doi.org/10.1007/s00259-018-4233-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333725PMC
February 2019
1 Read