1,998 results match your criteria European Journal of Medical Research[Journal]


Detection of serum MCP-1 and TGF-β1 in polymyositis/dermatomyositis patients and its significance.

Eur J Med Res 2019 Feb 14;24(1):12. Epub 2019 Feb 14.

Department of Immunology, No. 983 of the Chinese People's Liberation Army Joint Support Force, No. 60 of Huangwei Street, Hebei District, Tianjin, 300142, China.

Objective: This study aims to detect serum levels of monocyte chemoattractant protein-1 (MPC-1) and transforming growth factor-β1 (TGF-β1) in polymyositis/dermatomyositis (PM/DM) patients complicated with interstitial lung disease (ILD), to reveal the significance of the changes in these levels in the pathogenesis of PM/DM complicated with ILD.

Methods: Serum MCP-1 and TGF-β1 levels in PM/DM patients complicated with ILD, patients with pulmonary infections and normal controls (n = 30, each) were detected using enzyme-linked immunosorbent assay (ELISA), and the correlation between PM/DM complicated with ILD and serum MCP-1 and TGF-β1 levels was analyzed.

Results: Serum MCP-1 and TGF-β1 levels were both higher in PM/DM patients complicated with ILD compared with patients with pulmonary infections and normal controls. Read More

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http://dx.doi.org/10.1186/s40001-019-0368-7DOI Listing
February 2019

Hemodynamic consequences of intravenously given E. coli suspension: observations in a fulminant sepsis model in pigs, a descriptive case-control study.

Eur J Med Res 2019 Feb 13;24(1):11. Epub 2019 Feb 13.

Department of Anesthesiology and Intensive Care, Faculty of Medicine, University of Debrecen, Nagyerdei krt 98, Debrecen, 4032, Hungary.

Background: The aim of the present work was to assess systemic hemodynamic changes using PiCCo monitoring in a porcine model of E. coli-induced fulminant sepsis.

Methods: Thirty-one healthy female Hungahib pigs were randomly assigned into control (n = 15) or septic groups (n = 16). Read More

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http://dx.doi.org/10.1186/s40001-019-0372-yDOI Listing
February 2019
1 Read

Human umbilical cord mesenchymal stem cells implantation accelerates cutaneous wound healing in diabetic rats via the Wnt signaling pathway.

Eur J Med Res 2019 Feb 8;24(1):10. Epub 2019 Feb 8.

Department of Plastic Surgery, PLA General Hospital, 28 Fuxing Road, Beijing, People's Republic of China.

Objective: Difficulty in wound healing is one common complication of diabetes mellitus. The study explored whether the therapeutic effect of human umbilical cord mesenchymal stem cells (hUCMSCs) on diabetic ulcer wound was enhanced by the activation of the Wnt signaling pathway.

Methods: Rat diabetic model was established by intraperitoneal injection of Streptozotocin (STZ). Read More

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http://dx.doi.org/10.1186/s40001-019-0366-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367839PMC
February 2019
1 Read

The assessment of the kinematics of the rescuer in continuous chest compression during a 10-min simulation of cardiopulmonary resuscitation.

Eur J Med Res 2019 Feb 8;24(1). Epub 2019 Feb 8.

Wydział Lekarski z Oddziałem Lekarsko-Dentystycznym w Zabrzu, Śląski Uniwersytet Medyczny w Katowicach, Katowice, Poland.

Background: In pursuit of improvement in cardiopulmonary resuscitation (CPR), new technologies for the measurement and assessment of CPR quality are implemented. In our study, we assessed the kinematics of the rescuer during continuous chest compression (CCC-CPR). The proper performance of the procedure is a survival predictor for patients with cardiac arrest (CA). Read More

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http://dx.doi.org/10.1186/s40001-019-0369-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367769PMC
February 2019
1 Read

Neuroendocrine carcinoma of gallbladder: a case series and literature review.

Eur J Med Res 2019 Feb 4;24(1). Epub 2019 Feb 4.

Department of Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Shuaifuyuan 1#, Beijing, 100730, People's Republic of China.

Background: Neuroendocrine carcinoma (NEC) of gallbladder is a rare tumor. The clinical manifestation, treatment, and prognosis of gallbladder NEC are rarely reported.

Case Presentation: Eight gallbladder NEC patients were admitted into our hospital. Read More

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https://eurjmedres.biomedcentral.com/articles/10.1186/s40001
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http://dx.doi.org/10.1186/s40001-019-0363-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362567PMC
February 2019
4 Reads

TPPA titer as a new adaptation for early diagnosis of congenital syphilis: a retrospective analysis of observation over three years in Yunnan, China.

Eur J Med Res 2019 Feb 2;24(1). Epub 2019 Feb 2.

Department of Dermatology and Venereology, First Affiliated Hospital of Kunming Medical University, Kunming, 650032, China.

Background: Early diagnosis of congenital syphilis (CS) is difficult. This study aimed to determine the serological response discipline of syphilis passive antibody (SPA) in infants born to mothers with syphilis and provide the basis for the early diagnosis of CS.

Methods: Thirty-three infants born to mothers with syphilis and six infants with CS were recruited. Read More

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http://dx.doi.org/10.1186/s40001-019-0367-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359842PMC
February 2019

In vivo evaluation of a regenerative approach to nasal dorsum augmentation with a polycaprolactone-based implant.

Eur J Med Res 2019 Jan 28;24(1). Epub 2019 Jan 28.

Department of Plastic Surgery and Hand Surgery, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.

Background: Alternative techniques for nasal dorsum augmentation are of paramount importance in reconstructive and plastic surgery. In contrast to autologous cartilage grafts, tissue-engineered grafts can be created de novo and yield low-none donor site morbidity as compared to autologous grafts like rib or ear cartilage. To address this demand, this study investigated the in vivo regenerative potential of polycaprolactone-based implants as an alternative to autologous cartilage grafting during rhinoplasty. Read More

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http://dx.doi.org/10.1186/s40001-019-0364-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348657PMC
January 2019

Staurosporine induces apoptosis in pancreatic carcinoma cells PaTu 8988t and Panc-1 via the intrinsic signaling pathway.

Eur J Med Res 2019 Jan 28;24(1). Epub 2019 Jan 28.

Department of Anesthesiology, University Medical Center Regensburg, Franz Josef Strauss Allee 11, 93053, Regensburg, Germany.

Background: Cancer, one of the leading causes of death worldwide, develops when the normal balance between mitosis and apoptosis is disrupted. The subsequently increased proliferation rate or decreased apoptosis rate of cells leads to uncontrolled cellular growth. Thus, the current aim of cancer research is to increase the apoptosis rate in tumor cells-while limiting the concurrent death of healthy cells-and to induce controlled apoptosis in abnormal cells. Read More

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http://dx.doi.org/10.1186/s40001-019-0365-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348604PMC
January 2019

Orthogeriatric treatment reduces potential inappropriate medication in older trauma patients: a retrospective, dual-center study comparing conventional trauma care and co-managed treatment.

Eur J Med Res 2019 Jan 22;24(1). Epub 2019 Jan 22.

Department of General, Trauma and Reconstructive Surgery, University Hospital, LMU Munich, Marchioninistr. 15, 81377, Munich, Germany.

Background: Multimorbidity and polypharmacy are common challenges in the treatment of older trauma patients. Therefore, various integrated care models were developed over the last few years, merging the expertise of geriatricians and trauma surgeons. The aim of this study was to evaluate, if the number of prescriptions of potentially inappropriate medication (PIM) could be reduced in these patients by an interdisciplinary co-managed concept compared to conventional trauma care. Read More

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http://dx.doi.org/10.1186/s40001-019-0362-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341562PMC
January 2019
1 Read

Hand osteoid osteoma: evaluation of diagnosis and treatment.

Eur J Med Res 2019 Jan 21;24(1). Epub 2019 Jan 21.

Department of Orthopaedics, Faculty of Medicine, Bezmialem Vakif University, Vatan Cd, Fatih, 34093, Istanbul, Turkey.

Background: OO (osteoid osteoma) is a common, osteoblastic, benign bone tumor but rarely seen in the hand region. There is still some debate about the diagnosis and treatment of hand OOs. In the present study, we aimed to evaluate the epidemiology, radiologic features, surgical treatment options and functional outcomes. Read More

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https://eurjmedres.biomedcentral.com/articles/10.1186/s40001
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http://dx.doi.org/10.1186/s40001-019-0361-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340177PMC
January 2019
5 Reads

Eradication of Acinetobacter baumannii/Enterobacter cloacae complex in an open proximal tibial fracture and closed drop foot correction with a multidisciplinary approach using the Taylor Spatial Frame: a case report.

Eur J Med Res 2019 Jan 19;24(1). Epub 2019 Jan 19.

Department for General, Trauma and Reconstructive Surgery, University Hospital, LMU Munich, Ludwig-Maximilians-Universität München, Marchioninistr. 15, 81377, München, Germany.

Background: Multi-drug-resistant bacteria (e.g. Carbapenem-resistant Acinetobacter baumannii, extended-spectrum betalactamase or carbapenemase-producing enterobacteriaceae) are emerging in early-onset infections. Read More

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http://dx.doi.org/10.1186/s40001-019-0360-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339402PMC
January 2019
1 Read

Cardio-oncology: need for novel structures.

Eur J Med Res 2019 Jan 3;24(1). Epub 2019 Jan 3.

Department of Cardiology and Vascular Medicine, West German Heart and Vascular Center, Medical Faculty, University Hospital Essen, Hufelandstr. 55, 45147, Essen, Germany.

Cancer and cardiovascular diseases are the main causes for morbidity and mortality in modern society. In the United States of America (USA), over 1.7 million new cancer cases will presumably be observed in 2018. Read More

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http://dx.doi.org/10.1186/s40001-018-0359-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317192PMC
January 2019
1 Read

Association between bisphenol A diglycidyl ether-specific IgG in serum and food sensitization in young children.

Eur J Med Res 2018 Dec 26;23(1):61. Epub 2018 Dec 26.

Department of Environmental Health, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyusyu, Fukuoka Prefecture, 807-8555, Japan.

Background: Recent studies have reported that endocrine-disrupting compound (EDC) exposure is related to food sensitization. Bisphenol A diglycidyl ether (BADGE) is one of the most widespread EDCs and its biological effects are considered to be greater on children than on adults. This study investigated the relationship between serum BADGE-specific immunoglobulin G (IgG) concentrations and food sensitization in young children by measuring food-specific IgE levels. Read More

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http://dx.doi.org/10.1186/s40001-018-0358-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306001PMC
December 2018
1 Read

Occlusive dressing-induced secretomes influence the migration and proliferation of mesenchymal stem cells and fibroblasts differently.

Eur J Med Res 2018 Dec 26;23(1):60. Epub 2018 Dec 26.

Department for Trauma Surgery, Orthopedic Surgery and Plastic Surgery, University Medical Center Goettingen, Goettingen, Germany.

Background: Fingertip injuries treated with occlusive dressings (ODs) lead to nearly scar-free, functionally, and aesthetically pleasing results. We hypothesized that paracrine factors in the wound fluid (secretome) may influence migration and proliferation of mesenchymal stem cells (MSCs) and fibroblasts and modulate the wound-healing process.

Methods: We could collect wound fluid samples from 4 fingertip injuries and 7 split skin donor sites at the 5th day during dressing change. Read More

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https://eurjmedres.biomedcentral.com/articles/10.1186/s40001
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http://dx.doi.org/10.1186/s40001-018-0357-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306003PMC
December 2018
5 Reads

Noise insertion in CT for cocaine body packing: where is the limit of extensive dose reduction?

Eur J Med Res 2018 Dec 7;23(1):59. Epub 2018 Dec 7.

Department of Diagnostic and Interventional Radiology, Medical Faculty, University Dusseldorf, Moorenstr. 5, 40225, Dusseldorf, Germany.

Background: To evaluate the detection rate and image quality in CT-body-packer-screening at different radiation-dose levels and to determine a dose threshold that enables a reliable detection of incorporated body packs and incidental findings with a maximum of dose saving.

Materials And Methods: We retrospectively included 27 individuals who underwent an abdominal CT with automated exposure control due to suspected body packing. CT images were reconstructed at different radiation-dose levels of 50%, 10, 5% and 1% using iterative reconstructions. Read More

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http://dx.doi.org/10.1186/s40001-018-0356-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284291PMC
December 2018
1 Read

Transcanalicular laser dacryocystorhinostomy for acquired nasolacrimal duct obstruction: an audit of 104 patients.

Eur J Med Res 2018 Nov 16;23(1):58. Epub 2018 Nov 16.

Department of Ophthalmology, University of Cologne, Kerpener Strasse 62, 50924, Cologne, Germany.

Purpose: External dacryocystorhinostomy (DCR) is considered as the gold standard in the treatment of acquired nasolacrimal duct obstruction. However, many advances have been made towards the development of modern minimally invasive therapies. These new techniques were proven less harmful to the patients' skin and medial palpebral structures with their palpebral-canalicular pump mechanism. Read More

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https://eurjmedres.biomedcentral.com/articles/10.1186/s40001
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http://dx.doi.org/10.1186/s40001-018-0355-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238333PMC
November 2018
13 Reads

The effect of statin treatment on circulating coenzyme Q10 concentrations: an updated meta-analysis of randomized controlled trials.

Eur J Med Res 2018 Nov 10;23(1):57. Epub 2018 Nov 10.

China Heart Institute of Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing, China.

Background: The effect of statin treatment on circulating coenzyme Q10 (CoQ10) has been studied in numerous randomized controlled trails (RCTs). However, whether statin treatment decreases circulating CoQ10 is still controversial.

Methods: PubMed, EMBASE, and the Cochrane Library were searched to identify RCTs to investigate the effect of statin treatment on circulating CoQ10. Read More

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https://eurjmedres.biomedcentral.com/articles/10.1186/s40001
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http://dx.doi.org/10.1186/s40001-018-0353-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230224PMC
November 2018
9 Reads

Early endothelial progenitor cells and vascular stiffness in psoriasis and psoriatic arthritis.

Eur J Med Res 2018 Nov 9;23(1):56. Epub 2018 Nov 9.

Department of Medicine I, Cardiology-Angiology-Nephrology, Klinikum Brandenburg, Medizinische Hochschule Brandenburg, Brandenburg, Germany.

Background: Both psoriasis (Ps) and psoriasis arthritis (PsA) have been associated with increased cardiovascular risk. Also, both are characterized by increased neovascularization. Endothelial progenitor cells (EPCs) have been implicated in promoting vascular repair in ischemic diseases. Read More

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https://eurjmedres.biomedcentral.com/articles/10.1186/s40001
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http://dx.doi.org/10.1186/s40001-018-0352-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225664PMC
November 2018
11 Reads

MicroRNA profiling of diabetic atherosclerosis in a rat model.

Eur J Med Res 2018 Nov 3;23(1):55. Epub 2018 Nov 3.

The First Department of General Surgery, The First People's Hospital of Yunnan Province, 157 JinBi Road, Kunming, 650032, Yunnan, People's Republic of China.

Objective: The incidence of diabetic atherosclerosis (DA) is increasing worldwide. The study aim was to identify differentially expressed microRNAs (DE-miRs) potentially associated with the initiation and/or progression of DA, thereby yielding new insights into this disease.

Methods: Matched iliac artery tissue samples were isolated from 6 male rats with or without DA. Read More

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https://eurjmedres.biomedcentral.com/articles/10.1186/s40001
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http://dx.doi.org/10.1186/s40001-018-0354-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215356PMC
November 2018
9 Reads
1.400 Impact Factor

Skarzynski Tinnitus Scale: validation of a brief and robust tool for assessing tinnitus in a clinical population.

Eur J Med Res 2018 Nov 1;23(1):54. Epub 2018 Nov 1.

World Hearing Center, Institute of Physiology and Pathology of Hearing, 17 Mokra st., Kajetany / 10 Mochnackiego, 02-042, Warsaw, Poland.

Background: Many tinnitus scales are available, but all of them have certain limitations. The aim of the current study was to present a psychometric data of a new brief and reliable questionnaire that could be conveniently used for evaluating tinnitus complaint in adults (either with normal or impaired hearing)-Skarzynski Tinnitus Scale (STS).

Methods: The study included 125 participants with at least 1 month of tinnitus duration. Read More

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http://dx.doi.org/10.1186/s40001-018-0347-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211414PMC
November 2018
2 Reads

Treatment of onychomycosis using a 1064-nm diode laser with or without topical antifungal therapy: a single-center, retrospective analysis in 56 patients.

Eur J Med Res 2018 Oct 24;23(1):53. Epub 2018 Oct 24.

Department of Dermatology, Heinrich-Heine-University, 40225, Düsseldorf, Germany.

Background: Currently available treatment options for onychomycosis such as topical and systemic antifungals are often of limited efficacy, difficult to administer or associated with relevant side effects. Non-ablative laser therapy is proposed to represent a safe alternative without the disadvantages of drugs. Yet, to date, the efficacy of laser therapy for onychomycosis is discussed controversially. Read More

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https://eurjmedres.biomedcentral.com/articles/10.1186/s40001
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http://dx.doi.org/10.1186/s40001-018-0340-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199788PMC
October 2018
8 Reads

A phase I-II controlled randomized trial using a promising novel cell-free formulation for articular cartilage regeneration as treatment of severe osteoarthritis of the knee.

Eur J Med Res 2018 Oct 24;23(1):52. Epub 2018 Oct 24.

Esteripharma México, S.A. de C.V, Patricio Sanz 1582, Colonia del Valle Centro, 03100, Ciudad de México, Mexico.

Background: A promising novel cell-free bioactive formulation for articular cartilage regeneration, called BIOF2, has recently been tested in pre-clinical trials. The aim of the present study was to evaluate the efficacy and safety of BIOF2 for intra-articular application in patients with severe osteoarthritis of the knee.

Methods: A prospective, randomized, 3-arm, parallel group clinical trial was conducted. Read More

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https://eurjmedres.biomedcentral.com/articles/10.1186/s40001
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http://dx.doi.org/10.1186/s40001-018-0349-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199741PMC
October 2018
19 Reads

Frequency of atrial thrombus formation in patients with atrial fibrillation under treatment with non-vitamin K oral anticoagulants in comparison to vitamin K antagonists: a systematic review and meta-analysis.

Eur J Med Res 2018 Oct 23;23(1):49. Epub 2018 Oct 23.

Department of Cardiovascular Medicine, University Hospital Münster, 48149, Münster, Germany.

Background: To assess the frequency of left atrium/left atrial appendage (LA/LAA) thrombus under treatment with non-vitamin K oral anticoagulants (NOACs) in comparison with vitamin K antagonists (VKAs) in patients with non-valvular atrial fibrillation (AF).

Methods: PubMed, Web of Science™, EMBASE and the Cochrane Library databases were searched for studies comparing NOACs with VKAs in AF patients who underwent diagnostic transoesophageal echocardiography (TEE).

Results: A total of four trials were considered eligible and were included in the meta-analysis. Read More

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https://eurjmedres.biomedcentral.com/articles/10.1186/s40001
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http://dx.doi.org/10.1186/s40001-018-0350-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198509PMC
October 2018
4 Reads

Donor liver quality after hypovolemic shock and venous systemic oxygen persufflation in an experimental animal model.

Eur J Med Res 2018 Oct 23;23(1):51. Epub 2018 Oct 23.

Department of Surgery, Faculty of Medicine, Rheinische Friedrich-Wilhelms-Universität, Sigmund-Freudstr. 25, 53127, Bonn, Germany.

Background: The ever growing demand for liver transplantation inevitably necessitates an expansion of the donor pool. Utilization of "shock organs" is considered suboptimal to date while the associated outcome has hardly been investigated.

Materials And Methods: Male Wistar rats underwent a period of 30 min of hypovolemic shock. Read More

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http://dx.doi.org/10.1186/s40001-018-0346-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198357PMC
October 2018
1 Read

Analysis of the bony geometry of the acromio-clavicular joint.

Eur J Med Res 2018 Oct 23;23(1):50. Epub 2018 Oct 23.

Department of Trauma Surgery, Klinikum rechts der Isar, Technical University of Munich, Germany, Ismaninger Strasse 22, 81675, Munich, Germany.

Background: The primary goal of this study was to analyse the anatomic configuration of the acromio-clavicular joint in a healthy population to be able to develop a classification in a second step. On the basis of the primary findings a secondary goal was to find potential clinical indications in refer to AC-joint dislocation and lateral clavicle fractures.

Methods: The upper thoracic aperture including both shoulder joints as well as both sterno-clavicular joints was retrospectively reformatted in a bone kernel in axial orientation with 0. Read More

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https://eurjmedres.biomedcentral.com/articles/10.1186/s40001
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http://dx.doi.org/10.1186/s40001-018-0348-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198440PMC
October 2018
15 Reads

Screening breast magnetic resonance imaging in women with hormone replacement therapy.

Eur J Med Res 2018 Oct 20;23(1):48. Epub 2018 Oct 20.

Department of Reproductive Endocrinology, Hangzhou Women's Hospital, Kunpeng Road 369, Hangzhou, 310008, China.

Objective: The objective of this study was to compare the performance of screening mammography versus magnetic resonance imaging (MRI) in hormone replacement therapy (HRT) users.

Methods: We performed a retrospective review of 4628 women who had mammography or breast MRI screening from the beginning of HRT use at three institutions from April 2005 to December 2015. Information of demographics, number of biopsies performed and pathologic outcomes were collected. Read More

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http://dx.doi.org/10.1186/s40001-018-0351-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195689PMC
October 2018
3 Reads

No association of TP53 codon 72 and intron 3 16-bp duplication polymorphisms with breast cancer risk in Chinese Han women: new evidence from a population-based case-control investigation.

Eur J Med Res 2018 Oct 11;23(1):47. Epub 2018 Oct 11.

Department of Gynecologic Oncology, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing Medical University Affiliated Cancer Hospital, 42# Baiziting Street, Nanjing, 210009, Jiangsu, People's Republic of China.

Background: Many studies have demonstrated that the genetic variants of tumor suppressor gene TP53 contribute to the prediction of breast cancer risk. However, most of them focused on Europeans and Americans; the investigations about Asians, especially Chinese women, are scarce. Thus, the aim of this study was to explore the influence of TP53 codon 72 and intron 3 16-bp duplication polymorphisms on the breast cancer risk in Chinese women, especially those from eastern China. Read More

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http://dx.doi.org/10.1186/s40001-018-0345-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180397PMC
October 2018
1 Read

The Munich Ankle Questionnaire (MAQ): a self-assessment tool for a comprehensive evaluation of ankle disorders.

Eur J Med Res 2018 Sep 28;23(1):46. Epub 2018 Sep 28.

Klinik und Poliklinik für Unfallchirurgie, Klinikum rechts der Isar, Technische Universität München, Ismaninger Str. 22, 81675, Munich, Germany.

Background: There are many approved patient-related outcome measurement tools regarding ankle pathologies. However, there is none incorporating the range of motion (ROM) as an objective parameter. Most instruments focus on subjective parameters such as pain and impairment at work or daily living. Read More

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http://dx.doi.org/10.1186/s40001-018-0344-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161467PMC
September 2018
1 Read

Ingenol mebutate induces a tumor cell-directed inflammatory response and antimicrobial peptides thereby promoting rapid tumor destruction and wound healing.

Eur J Med Res 2018 Sep 28;23(1):45. Epub 2018 Sep 28.

Department of Dermatology, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.

Background: Ingenol mebutat (IM)-gel is effective for the topical treatment of epithelial tumors, including actinic keratoses (AKs) or anogenital warts (AGW). AK patients treated with IM develop intensified inflammatory reactions on sights of prior clinical visible or palpable AKs as compared to the surrounding actinically damaged skin, suggesting the induction of a tumor cell-directed inflammation. AGW patients treated with IM develop even stronger inflammatory reactions with large erosions, suggesting a directed inflammatory response against HPV-infected keratinocytes. Read More

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http://dx.doi.org/10.1186/s40001-018-0343-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161468PMC
September 2018
5 Reads

Prospective randomized controlled trial in the treatment of lateral epicondylitis with a new dynamic wrist orthosis.

Eur J Med Res 2018 Sep 15;23(1):43. Epub 2018 Sep 15.

Orthopaedic-Surgery Centre (OCC), Tübingen, Germany.

Background: In the treatment of lateral epicondylitis (LE), the role of a new dynamic wrist orthosis is unclear.

Patients And Methods: Patients suffering from a LE longer than 3 months were multicentrically and prospectively randomized into a physiotherapeutic group (PT group) and in a physiotherapy group plus wrist orthosis (PT + O group). Physiotherapy consisted of daily eccentric strengthening exercises under initial professional supervision. Read More

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http://dx.doi.org/10.1186/s40001-018-0342-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6138897PMC
September 2018
4 Reads

Polymorphonuclear (PMN) elastase in patients after severe traumatic brain injury.

Eur J Med Res 2018 Sep 15;23(1):44. Epub 2018 Sep 15.

Department of Trauma Surgery, Klinikum rechts der Isar, Technical University of Munich, Ismaninger Str. 22, 81675, Munich, Germany.

Background: Data on PNM elastase levels in cerebrospinal fluid following traumatic brain injury (TBI) in humans are not available in the literature. Therefore, the aim of this prospective study was to evaluate the dynamics of PMN elastase in the cerebrospinal fluid (CSF) of patients after TBI.

Methods: Patients suffering from isolated, closed TBI, presenting with an initial Glasgow coma score ≤ 8 and with intracerebral hemorrhage on the initial cranial computed tomography scan (performed within 90 min after TBI) were enrolled. Read More

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http://dx.doi.org/10.1186/s40001-018-0341-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6138888PMC
September 2018
1 Read

Elbow arthroscopy in children and adolescents: analysis of outcome and complications.

Eur J Med Res 2018 Sep 15;23(1):42. Epub 2018 Sep 15.

Orthopaedic-Surgery Center (OCC), Tübingen, Germany.

Background: Chondral or osteochondral lesions, post-traumatic contracture and loose bodies of the elbow are often associated with chronic pain, stiffness, repetitive swelling and joint blockages. Therefore, arthroscopy of the elbow is often used in the elderly for the treatment of osteochondral defects or arthrolysis. There are only a few reports and studies about arthroscopic therapy of the elbow in children and adolescents. Read More

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https://eurjmedres.biomedcentral.com/articles/10.1186/s40001
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http://dx.doi.org/10.1186/s40001-018-0338-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6138926PMC
September 2018
13 Reads

A comparative study on the validity and reliability of anterior, medial, and posterior approaches for internal fixation in the repair of fractures of the coronoid process of the ulna.

Eur J Med Res 2018 Sep 11;23(1):40. Epub 2018 Sep 11.

Department of Orthopedics, Ningbo NO.6 Hospital, Ningbo, 315040, People's Republic of China.

Background: The coracoid process plays an important role in maintaining the stability of the elbow joint. A fracture of the coronoid process is often treated via surgical approaches, including open reduction and internal fixation, which aim to regain a stable, flexible, and loadable joint. In this study, we compared the anterior, medial, and posterior approaches of internal fixation in the repair of fractures of the coronoid process of the ulna. Read More

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http://dx.doi.org/10.1186/s40001-018-0336-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6131958PMC
September 2018
10 Reads

Evaluation of preoperative anxiety and fear of anesthesia using APAIS score.

Eur J Med Res 2018 Sep 11;23(1):41. Epub 2018 Sep 11.

Department of Anesthesiology, Suleymaniye Obstetrics & Pediatrics Training and Research Hospital, Istanbul, Turkey.

Background: Preoperative anxiety is one of the most important problems for the patients, because it causes emotional and psychiatric problems as well as physical problems. It is crucial to detect the patient's existing anxiety to assist patients. Our primary aim in this study is to investigate how the patient's age, gender, the operation, surgical briefing, type of anesthesia recommended for the operation ahead, and patient's prior anesthesia experience affect the patient's anxieties. Read More

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http://dx.doi.org/10.1186/s40001-018-0339-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6131845PMC
September 2018
3 Reads

Biomechanical and histological analyses of the fracture healing process after direct or prolonged reduction.

Eur J Med Res 2018 Sep 4;23(1):39. Epub 2018 Sep 4.

Hannover Medical School (MHH) -Trauma Department, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.

Background: Reduction of femoral shaft fractures remains a challenging problem in orthopaedic surgery. Robot-assisted reduction might ease reduction and fracture treatment. However, the influence of different reduction pathways on patients' physiology is not fully known yet. Read More

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http://dx.doi.org/10.1186/s40001-018-0337-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122772PMC
September 2018
2 Reads

Vasomotion of mice mesenteric arteries during low oxygen levels.

Eur J Med Res 2018 Aug 25;23(1):38. Epub 2018 Aug 25.

Department of Anesthesiology and Intensive Care Medicine, Justus-Liebig University Giessen, Rudolph-Buchheimstr. 7, 35392, Giessen, Germany.

Background: Ischemia of intestinal organs is a main cause of complications in surgical intensive care patients. Changes in the tonus of arteries contributing to vascular resistance play an important role in the determination of blood flow and thus oxygen supply of various abdominal organs. It is generally acknowledged that hypoxia itself is able to alter arterial tonus and thus blood flow. Read More

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https://eurjmedres.biomedcentral.com/articles/10.1186/s40001
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http://dx.doi.org/10.1186/s40001-018-0335-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109325PMC
August 2018
13 Reads

Standardized in vitro analysis of the degradability of hyaluronic acid fillers by hyaluronidase.

Eur J Med Res 2018 Aug 20;23(1):37. Epub 2018 Aug 20.

Departments of Dermatology, Medical Faculty, Research Laboratory for Dermatology and Immunology, Heinrich-Heine-University Duesseldorf, University Hospital Duesseldorf, Duesseldorf, Germany.

Background: Hyaluronidase is a hyaluronic acid (HA) metabolizing enzyme, which is approved as an adjuvant for infiltration anesthesia. The "off-label" use of hyaluronidase is regarded as gold standard for the management of HA-filler-associated complications. Yet, up to date there are only few studies that have systematically assessed the degradability of different HA-fillers by hyaluronidase. Read More

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https://eurjmedres.biomedcentral.com/articles/10.1186/s40001
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http://dx.doi.org/10.1186/s40001-018-0334-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6100712PMC
August 2018
6 Reads

Dynamic coronary roadmapping during percutaneous coronary intervention: a feasibility study.

Eur J Med Res 2018 Jul 31;23(1):36. Epub 2018 Jul 31.

Medical Faculty, Division of Cardiology, Pulmonology and Vascular Medicine, Heinrich-Heine University, Moorenstr. 5, 40225, Düsseldorf, Germany.

Background: A novel software ("Dynamic Coronary Roadmap") was developed, which offers a real-time, dynamic overlay of the coronary tree on fluoroscopy. Once the roadmap has been automatically generated during angiography it can be used for navigation during percutaneous coronary interventions (PCI). As a feasibility study, we aimed to investigate the feasibility of real-time dynamic coronary roadmapping and consecutive coronary overlay during elective PCI. Read More

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http://dx.doi.org/10.1186/s40001-018-0333-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6069549PMC
July 2018
4 Reads

Patient satisfaction after hook plate treatment of bony avulsion fracture of the distal phalanges.

Eur J Med Res 2018 Jul 20;23(1):35. Epub 2018 Jul 20.

Interdisciplinary Hand Department IHZ, Department of Trauma Surgery, Klinikum rechts der Isar, Technical University Munich, Munich, Germany.

Background: Bony avulsion fractures of the distal phalanges can result in mallet finger deformity if not treated appropriately. Therefore, only minimally displaced fractures can be treated conservatively with a good outcome, as dislocation occurs very often. Several surgical treatment options have been developed during the past decades. Read More

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http://dx.doi.org/10.1186/s40001-018-0332-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6053819PMC
July 2018
4 Reads

The influence of polymorphic GSTM1 gene on the increased susceptibility of non-viral hepatic cirrhosis: evidence from observational studies.

Eur J Med Res 2018 Jun 19;23(1):34. Epub 2018 Jun 19.

Department of Nursing, Jiading District Central Hospital Affiliated Shanghai University of Medicine & Health Sciences, 1 Cheng Bei Road, Jiading District, Shanghai, 201800, China.

It is reported that glutathione S-transferase mu (GSTM1) polymorphism is associated with non-viral hepatic cirrhosis (HC). However, some studies showed different views. Therefore, in this paper, a meta-analysis was conducted to get a more comprehensive understanding of GSTM1 polymorphisms in non-viral HC susceptibility. Read More

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http://dx.doi.org/10.1186/s40001-018-0331-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6011196PMC
June 2018
8 Reads

Correction to: Correlation analysis on serum inflammatory cytokine level and neurogenic pulmonary edema for children with severe hand-foot-mouth disease.

Eur J Med Res 2018 Jun 15;23(1):33. Epub 2018 Jun 15.

Department of Infections Disease, Zaozhuang Municipal Hospital, Leading Road No. 41, Shizhong District, Zaozhuang, 277100, Shandong, China.

The original publication of this article [1] contained two erroneous paragraphs related to the time and place for the admission of the pediatric patients with clinically diagnosed severe HFMD. The updated information has been indicated in bold. Read More

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http://dx.doi.org/10.1186/s40001-018-0327-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003195PMC
June 2018
8 Reads

Closure simulation for reduction of emergency patient diversion: a discrete agent-based simulation approach to minimizing ambulance diversion.

Eur J Med Res 2018 Jun 8;23(1):32. Epub 2018 Jun 8.

Klinik und Poliklinik für Unfallchirurgie, Klinikum rechts der Isar, Technische Universität München, Ismaninger Str. 22, 81675, Munich, Germany.

Background: The city of Munich uses web-based information system IVENA to promote exchange of information regarding hospital offerings and closures between the integrated dispatch center and hospitals to support coordination of the emergency medical services. Hospital crowding resulting in closures and thus prolonged transportation time poses a major problem. An innovative discrete agent model simulates the effects of novel policies to reduce closure times and avoid crowding. Read More

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http://dx.doi.org/10.1186/s40001-018-0330-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5994037PMC
June 2018
1 Read

Membrane-bound estrogen receptor alpha initiated signaling is dynamin dependent in breast cancer cells.

Eur J Med Res 2018 Jun 7;23(1):31. Epub 2018 Jun 7.

2nd Department of Medicine, Semmelweis University, Budapest, Szentkirályi utca 46., 1088, Hungary.

Background: Although membrane-associated estrogen receptors (mERs) have been known to play important role in steroid-induced signal transmission, we still know little about their function in the estrogen-induced proliferation of breast cancer cells.

Methods: In our current work we tried to separate membrane-initiated estrogen receptor signaling from the overall estrogenic effect in MCF-7 breast carcinoma cells. Re-analyzing expression data from multiple microarray experiments, we selected a set of key regulatory genes involved in proliferation regulation and estrogen signaling to monitor estrogen-induced transcription changes. Read More

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http://dx.doi.org/10.1186/s40001-018-0328-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992704PMC
June 2018
32 Reads

Non-linear optical microscopy and histological analysis of collagen, elastin and lysyl oxidase expression in breast capsular contracture.

Eur J Med Res 2018 Jun 4;23(1):30. Epub 2018 Jun 4.

Experimental Trauma Surgery, Department of Trauma Surgery, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.

Background: Capsular contracture is one of the most common complications in surgical interventions for aesthetic breast augmentation or post-mastectomy breast reconstruction involving the use of silicone prostheses. Although the precise cause of capsular contracture is yet unknown, the leading hypothesis is that it is caused by long-term unresolved foreign body reaction towards the silicone breast implant. To authors' best knowledge, this is the first study that elucidates the presence of lysyl oxidase (LOX)-an enzyme that is involved in collagen and elastin crosslinking within fibrous capsules harvested from patients with severe capsular contracture. Read More

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http://dx.doi.org/10.1186/s40001-018-0322-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987584PMC
June 2018
8 Reads

Comparison of the sixth and the seventh editions of the UICC classification for intrahepatic cholangiocarcinoma.

Eur J Med Res 2018 Jun 1;23(1):29. Epub 2018 Jun 1.

Department of General, Visceral and Transplantation Surgery, University Hospital Essen, University Duisburg-Essen, Hufelandstrasse 55, 45147, Essen, Germany.

Background: The current seventh edition of the TNM classification for intrahepatic cholangiocarcinoma (ICC) includes tumor number, vascular invasion, lymph node involvement but no longer the tumor size as compared to the sixth edition. The impact of the seventh edition on stage-based prognostic prediction for patients with ICC was evaluated.

Methods: Between 03/2001 and 02/2013, 98 patients with the diagnosis of an ICC were surgically treated at our center. Read More

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http://dx.doi.org/10.1186/s40001-018-0329-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984789PMC
June 2018
11 Reads

A lightweight sensing platform for monitoring sleep quality and posture: a simulated validation study.

Eur J Med Res 2018 May 30;23(1):28. Epub 2018 May 30.

Imperial College Healthcare NHS Trust, London, UK.

Background: The prevalence of self-reported shoulder pain in the UK has been estimated at 16%. This has been linked with significant sleep disturbance. It is possible that this relationship is bidirectional, with both symptoms capable of causing the other. Read More

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http://dx.doi.org/10.1186/s40001-018-0326-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5975552PMC
May 2018
3 Reads

Limitations in clinical outcome after posterior stabilization of thoracolumbar fractures do not correlate with dynamic trunk muscle dysfunction: an ultrasound controlled prospective cohort study.

Eur J Med Res 2018 May 24;23(1):26. Epub 2018 May 24.

Department of Trauma, University of Zurich, Rämistrasse 100, 8091, Zurich, Switzerland.

Background And Purpose: Posterior stabilization of the spine is associated with iatrogenic muscle damage. This is discussed to represent an important cause of postoperative pain, especially in open reduction and fixation. The aim of this study was to visualize muscular changes after open or percutaneous posterior stabilization of traumatic thoracolumbar spine fractures and to investigate whether or not these changes are related to the clinical outcome. Read More

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http://dx.doi.org/10.1186/s40001-018-0323-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968479PMC
May 2018
6 Reads

Clinical effect of selective interventional therapy on sub-acute ST-segment elevation myocardial infarction under the guidance of fractional flow reserve and coronary arteriography.

Eur J Med Res 2018 May 24;23(1):27. Epub 2018 May 24.

Department of Cardiology, Huai'an First People's Hospital, Nanjing Medical University, No. 6 West Beijing Road, Huaiyin District, Huai'an, 223300, China.

Objective: This study aims to compare the clinical effects of selective interventional therapy (PCI) under the guidance of fractional flow reserve (FFR) and coronary arteriography.

Methods: Patients with sub-acute ST-segment elevation myocardial infarction (sub-acute STEMI), who were under selective PCI treatment between April 2012 and June 2014, were included into this study. These patients were divided into two groups, based on FFR measurements: FFR-PCI group and radiography-PCI group. Read More

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http://dx.doi.org/10.1186/s40001-018-0319-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968604PMC
May 2018
2 Reads

Impact of anticoagulation and vasoactive medication on regained radial artery patency after catheterization: a case-control study.

Eur J Med Res 2018 May 22;23(1):25. Epub 2018 May 22.

Department of Cardiology and Vascular Medicine, West German Heart and Vascular Center Essen, Medical Faculty, University Hospital Essen, Hufelandstr. 55, 45147, Essen, Germany.

Background: Radial artery access is the primary approach for coronary interventions due to higher safety profile in comparison to femoral access. Radial artery occlusion (RAO) is the main complication of transradial catheterization that can lead to severe symptoms and a permanent artery occlusion. The incidence of RAO after transradial access ranges from 5 to 38% and data regarding treatment is scarce. Read More

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http://dx.doi.org/10.1186/s40001-018-0324-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964909PMC
May 2018
6 Reads

Loop ostomy following laparoscopic low anterior resection for rectal cancer after neoadjuvant chemoradiotherapy.

Eur J Med Res 2018 May 22;23(1):24. Epub 2018 May 22.

Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 1 Shuaifuyuan, Wangfujing, Dongcheng District, Beijing, 100730, China.

Background: Both loop ileostomy (LI) and loop transverse colostomy (LTC) could achieve absolute fecal diversion and have several advantages. This study compared LI and LTC following laparoscopic low anterior resection for rectal cancer after neoadjuvant chemoradiotherapy.

Methods: Between January 2009 and December 2016, 186 patients who underwent laparoscopic low anterior resection for rectal cancer and loop ostomy were included. Read More

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http://dx.doi.org/10.1186/s40001-018-0325-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964642PMC
May 2018
4 Reads
1.400 Impact Factor