15,323 results match your criteria European Journal of Immunology [Journal]


Successful direct-acting antiviral therapy in HIV/HCV co-infected patients fails to restore circulating mucosal-associated invariant T cells.

Eur J Immunol 2019 Apr 15. Epub 2019 Apr 15.

Clinic of Infectious Diseases, Department of Health Sciences, ASST Santi Paolo e Carlo, University of Milan.

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http://dx.doi.org/10.1002/eji.201948152DOI Listing

Avraham Ben-Nun-Pioneer, fighter, friend.

Eur J Immunol 2019 Apr;49(4):521-522

Max-Planck-Institute of Neurobiology, Martinsried, Germany and Biomedical Center, University, Munich, Germany.

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http://dx.doi.org/10.1002/eji.201970046DOI Listing

Impressum.

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Eur J Immunol 2019 Apr;49(4):666

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http://dx.doi.org/10.1002/eji.201970047DOI Listing

Inhibition of the sphingosine-1-phosphate pathway promotes the resolution of neutrophilic inflammation.

Eur J Immunol 2019 Apr 2. Epub 2019 Apr 2.

Departamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.

Sphingosine-1-phosphate (S1P) is an important sphingolipid derived from plasma membrane and has a known role in productive phase of inflammation, but its role in neutrophil survival and resolution phase of inflammation is unknown. Here, we investigated the effects of inhibition of S1P receptors and the blockade of S1P synthesis in BALB/c mice and human neutrophils. S1P and S1PR1-3 receptors expression were increased in cells from the pleural cavity stimulated with lipopolysaccharide (LPS). Read More

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http://dx.doi.org/10.1002/eji.201848049DOI Listing
April 2019
1 Read

Recruitment of hepatic macrophages from monocytes is independent of IL-4Rα but is associated with ablation of resident macrophages in schistosomiasis.

Eur J Immunol 2019 Mar 28. Epub 2019 Mar 28.

Immunology-Vaccinology, Department of Infectious and Parasitic Diseases, Faculty of Veterinary Medicine - FARAH, University of Liège, Liège, Belgium.

Alternatively-activated Mφs (AAMφ) accumulate in hepatic granulomas during schistosomiasis and have been suggested to originate in the bone marrow. What is less understood is how these Mφ responses are regulated after S. mansoni infection. Read More

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http://dx.doi.org/10.1002/eji.201847796DOI Listing
March 2019
1 Read

Human T-cell receptor V gene segment of alpha and beta families: A revised primer design strategy.

Eur J Immunol 2019 Mar 28. Epub 2019 Mar 28.

Institute for Research in Molecular Medicine, Universiti Sains Malaysia, Penang, Malaysia.

The application of human TCR in cancer immunotherapy has gained momentum with developments in tumor killing strategies using endogenous adaptive immune responses. The successful coverage of a diverse TCR repertoire is mainly attributed to the primer design of the human TCR V genes. Here, we present a refined primer design strategy of the human TCR V gene by clustering V gene sequence homolog for degenerate primer design based on the data from IMGT. Read More

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http://dx.doi.org/10.1002/eji.201747328DOI Listing

Brucella abortus nitric oxide metabolite regulates inflammasome activation and IL-1β secretion in murine macrophages.

Eur J Immunol 2019 Mar 28. Epub 2019 Mar 28.

Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.

NLRP3 inflammasome is a protein complex crucial to caspase-1 activation and IL-1β and IL-18 maturation. This receptor participates in innate immune responses to different pathogens, including the bacteria of genus Brucella. Our group recently demonstrated that Brucella abortus-induced IL-1β secretion involves NLRP3 inflammasome and it is partially dependent on mitochondrial ROS production. Read More

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http://dx.doi.org/10.1002/eji.201848016DOI Listing

TCR density in early iNKT cell precursors regulates agonist selection and subset differentiation in mice.

Eur J Immunol 2019 Mar 26. Epub 2019 Mar 26.

INSERM, UMR-1160, Institut Universitaire d'Hématologie, Paris, France.

It is established that iNKT cells are a cell type that require strong TCR signal for their proper development and represent a model for thymic agonist selection. The nature of the signal perceived by iNKT cells promoting their specification is not well understood. To address this question, we analyzed iNKT cell development in relevant TCR Vα14-Jα18 alpha chain transgenic mice (Vα14Tg). Read More

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http://dx.doi.org/10.1002/eji.201848010DOI Listing

Aspergillus fumigatus corneal infection is regulated by chitin synthases and by neutrophil-derived acidic mammalian chitinase.

Eur J Immunol 2019 Mar 23. Epub 2019 Mar 23.

Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, Ohio, United States.

Aspergillus fumigatus is an important cause of pulmonary and systemic infections in immune compromised individuals, and of corneal ulcers and blindness in immune competent patients. To examine the role of chitin synthases in Aspergillus corneal infection, we analyzed Aspergillus mutants of chitin synthase family 1 and family 2, and found that the quadruple mutants from both families were more readily killed by neutrophils in vitro, and that both exhibited an impaired ability to grow in the cornea. Further, inhibition of chitin synthases using Nikkomycin Z enhanced neutrophil killing in vitro and in vivo in a murine model of A. Read More

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http://dx.doi.org/10.1002/eji.201847851DOI Listing

Human milk oligosaccharides promote immune tolerance via direct interactions with human dendritic cells.

Eur J Immunol 2019 Mar 22. Epub 2019 Mar 22.

Departments of Immunology and of Human Milk Research & Analytical Science, Danone Nutricia Research, Utrecht, The Netherlands.

Human milk oligosaccharides (HMOS) are a complex mixture of bioactive components supporting the immune development of breastfed-infants. Dendritic cells (DCs) play a central role in the regulation of immune responses, being specialized in antigen presentation and driving T-cell priming as well as differentiation. However, little is known about the direct effects of HMOS on human DC phenotypes and functions. Read More

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http://dx.doi.org/10.1002/eji.201847971DOI Listing

Autoreactive B-lymphocytes in SLE and RA patients: Isolation and characterisation using extractable nuclear and citrullinated antigens bound to immunobeads.

Eur J Immunol 2019 Mar 20. Epub 2019 Mar 20.

Servicio de Inmunología, UGC de Hematología, Inmunología y Genética, Hospital Universitario Puerta del Mar (HUPM), Cádiz, Spain.

Systemic lupus erythematosus and rheumatoid arthritis are autoimmune diseases characterised by B-cell hyperactivation and production of autoantibodies (AutoAbs) against various self-antigens, including extractable nuclear antigens and citrullinated peptides. Therefore, B lymphocytes and antibody-secreting cells are considered relevant targets for therapies. However, isolation and characterisation of auto-reactive specific B lymphocytes are limited, primarily due to technical issues. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/eji.20184806
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http://dx.doi.org/10.1002/eji.201848065DOI Listing
March 2019
4 Reads

Rituximab/Bendamustine treatment of chronic lymphatic leukemia leads to sustained remission of antiphospholipid antibodies.

Eur J Immunol 2019 Mar 20. Epub 2019 Mar 20.

Department of Rheumatology, American University of Beirut, Beirut, Lebanon.

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http://dx.doi.org/10.1002/eji.201848042DOI Listing
March 2019
3 Reads

Expression of c-Kit discriminates between two functionally distinct subsets of human type 2 innate lymphoid cells.

Eur J Immunol 2019 Mar 20. Epub 2019 Mar 20.

Center for Infectious Medicine, Department of Medicine, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, Sweden.

Human type 2 innate lymphoid cells (ILC2) are the only ILC subset that shows heterogeneous expression of the SCF receptor c-Kit (CD117). Despite its use as surface marker to distinguish ILC populations, its influence on ILC2 biology has not been investigated. Here, we show that c-Kit expression of peripheral blood ILC distinguishes two functionally distinct ILC2 subsets (c-Kit and c-Kit ). Read More

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http://dx.doi.org/10.1002/eji.201848006DOI Listing
March 2019
1 Read

Deletion of Galectin-3 attenuates acute pancreatitis in mice by affecting activation of innate inflammatory cells.

Eur J Immunol 2019 Mar 20. Epub 2019 Mar 20.

Center for Molecular Medicine and Stem Cell Research, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia.

Acute pancreatitis is characterized by autodigestion of pancreatic cells followed by acute inflammation leading to pathology and death. In experimental acute pancreatitis, pancreatic acinar cells and infiltrating macrophages express Galectin-3 but its role in pathology of this disease is unknown. Therefore, we studied its role using Galectin-3 deficient mice. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/eji.20184789
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http://dx.doi.org/10.1002/eji.201847890DOI Listing
March 2019
7 Reads

Peripheral and systemic antigens elicit an expandable pool of resident memory CD8 T cells in the bone marrow.

Eur J Immunol 2019 Mar 20. Epub 2019 Mar 20.

Department of Hematopoiesis, Sanquin Research, Amsterdam, The Netherlands.

BM has been put forward as a major reservoir for memory CD8  T cells. In order to fulfill that function, BM should "store" memory CD8 T cells, which in biological terms would require these "stored" memory cells to be in disequilibrium with the circulatory pool. This issue is a matter of ongoing debate. Read More

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http://dx.doi.org/10.1002/eji.201848003DOI Listing

Accelerated thymopoiesis and improved T-cell responses in HLA-A2/-DR2 transgenic BRGS-based human immune system mice.

Eur J Immunol 2019 Mar 19. Epub 2019 Mar 19.

Inserm U1223, Paris, France.

Human immune system (HIS) mouse models provide a robust in vivo platform to study human immunity. Nevertheless, the signals that guide human lymphocyte differentiation in HIS mice remain poorly understood. Here, we have developed a novel Balb/c Rag2 Il2rg Sirpa (BRGS) HIS mouse model expressing human HLA-A2 and -DR2 transgenes (BRGSA2DR2). Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/eji.20184800
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http://dx.doi.org/10.1002/eji.201848001DOI Listing
March 2019
9 Reads
4.034 Impact Factor

The B cell novel protein 1 (BCNP1) regulates BCR signaling and B cell apoptosis.

Eur J Immunol 2019 Mar 19. Epub 2019 Mar 19.

Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, China.

The BCR plays a central role in B cell development, survival, activation, and differentiation. We have identified the B cell novel protein 1 (BCNP1) as a new regulator of BCR signaling. BCNP1 contains a pleckstrin homology domain, three proline-rich motifs, and a potential SH2 binding site, and is predominantly expressed by B cells. Read More

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http://dx.doi.org/10.1002/eji.201847985DOI Listing
March 2019
4.034 Impact Factor

Creatine supplementation impairs airway inflammation in an experimental model of asthma involving P2 × 7 receptor.

Eur J Immunol 2019 Mar 19. Epub 2019 Mar 19.

Brazilian Institute of Teaching and Research in Pulmonary and Exercise Immunology (IBEPIPE), São José dos Campos, São Paulo, Brazil.

Creatine (Cr) is a substrate for adenosine triphosphate synthesis, and it is the most used dietary supplement among professional and recreative athletes and sportsmen. Creatine supplementation may increase allergic airway response, but the cellular and molecular mechanisms are unknown. We used murine model of OVA-induced chronic asthma and showed that Cr supplementation increased total proteins, ATP level, lymphocytes, macrophages, and IL-5 levels in BALF, as well as IL-5 in the supernatant of re-stimulated mediastinal lymph nodes. Read More

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http://dx.doi.org/10.1002/eji.201847657DOI Listing
March 2019
3 Reads

The Ubiquitin-proteasome pathway regulates Nectin2/CD112 expression and impairs NK cell recognition and killing.

Eur J Immunol 2019 Mar 19. Epub 2019 Mar 19.

Department of Molecular Medicine, "Sapienza" University of Rome, Laboratory affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Rome, Italy.

Nectin2 is a member of immunoglobulin-like cell adhesion molecules and plays a prominent role in the establishment of adherens and tight junctions. It is also upregulated on the surface of tumor and virus-infected cells where it functions as a ligand for the activating receptor CD226, thus contributing to cytotoxic lymphocyte-mediated recognition and killing of damaged cells. Little is currently known about the regulation of Nectin2 expression and, in particular, whether posttranscriptional and posttranslational mechanisms are involved. Read More

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http://dx.doi.org/10.1002/eji.201847848DOI Listing

Expression of IL-7Rα and KLRG1 defines functionally distinct CD8 T-cell populations in humans.

Eur J Immunol 2019 Mar 18. Epub 2019 Mar 18.

Department of Experimental Immunology, Amsterdam Infection and Immunity Institute, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

During acute viral infections in mice, IL-7Rα and KLRG1 together are used to distinguish the short-lived effector cells (SLEC; IL-7Rα KLRG ) from the precursors of persisting memory cells (MPEC; IL-7Rα KLRG1 ). We here show that these markers can be used to define distinct subsets in the circulation and lymph nodes during the acute phase and in "steady state" in humans. In contrast to the T cells in the circulation, T cells derived from lymph nodes hardly contain any KLRG1-expressing cells. Read More

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http://dx.doi.org/10.1002/eji.201847897DOI Listing
March 2019
4 Reads

CD1b presents self and Borrelia burgdorferi diacylglycerols to human T cells.

Eur J Immunol 2019 Mar 10. Epub 2019 Mar 10.

Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.

Lyme disease is a common multisystem disease caused by infection with a tick-transmitted spirochete, Borrelia burgdorferi and related Borrelia species. The monoglycosylated diacylglycerol known as B. burgdorferi glycolipid II (BbGL-II) is a major target of antibodies in sera from infected individuals. Read More

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http://dx.doi.org/10.1002/eji.201847949DOI Listing
March 2019
3 Reads

T cell memory in Capri: A successful course organized by the EFIS-EJI Ruggero Ceppellini Advanced School of Immunology funded by Serafino Zappacosta.

Eur J Immunol 2019 Mar;49(3):361-363

Institute of Molecular Biology and Pathology, National Research Council (CNR), Rome, Italy.

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http://dx.doi.org/10.1002/eji.201970035DOI Listing

Impressum.

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Eur J Immunol 2019 Mar;49(3):508

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http://dx.doi.org/10.1002/eji.201970036DOI Listing

Cerebral adrenoleukodystrophy is associated with loss of tolerance to profilin.

Eur J Immunol 2019 Mar 4. Epub 2019 Mar 4.

Division of Pediatric Blood and Marrow Transplant, Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA.

Childhood cerebral adrenoleukodystrophy (cALD) is a devastating manifestation of ALD accompanied by demyelination, inflammation, and blood brain barrier (BBB) disruption with shared characteristics of an auto-immune disease. We utilized plasma samples pre- and postdevelopment of cALD to determine the presence of specific auto-antibodies. Mass spectrometry of protein specifically bound with post-cALD plasma antibody identified Profilin1 (PFN1) as the target. Read More

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http://dx.doi.org/10.1002/eji.201848043DOI Listing

The thioredoxin-1 and glutathione/glutaredoxin-1 systems redundantly fuel murine B-cell development and responses.

Eur J Immunol 2019 Feb 25. Epub 2019 Feb 25.

Institute of Molecular Health Sciences, ETH Zurich, Zürich, Switzerland.

Antioxidant systems maintain cellular redox homeostasis. The thioredoxin-1 (Trx1) and the glutathione (GSH)/glutaredoxin-1 (Grx1) systems are key players in preserving cytosolic redox balance. In fact, T lymphocytes critically rely on reducing equivalents from the Trx1 system for DNA biosynthesis during metabolic reprogramming upon activation. Read More

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http://dx.doi.org/10.1002/eji.201848044DOI Listing
February 2019

Epithelium-specific MyD88 signaling, but not DCs or macrophages, control acute intestinal infection with Clostridium difficile.

Eur J Immunol 2019 Feb 25. Epub 2019 Feb 25.

Institute of Infection Immunology, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Medical School Hannover (MHH) and the Helmholtz Centre for Infection Research (HZI), Hannover, Germany.

Infection with Clostridium difficile is one of the major causes of health care acquired diarrhea and colitis. Signaling though MyD88 downstream of TLRs is critical for initiating the early protective host response in mouse models of C. difficile infection (CDI). Read More

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http://dx.doi.org/10.1002/eji.201848022DOI Listing
February 2019
1 Read

Interferon signature in patients with STAT1 gain-of-function mutation is epigenetically determined.

Eur J Immunol 2019 Feb 23. Epub 2019 Feb 23.

Department of Biomedicine, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia.

STAT1 gain-of-function (GOF) variants lead to defective Th17 cell development and chronic mucocutaneous candidiasis (CMC), but frequently also to autoimmunity. Stimulation of cells with STAT1 inducing cytokines like interferons (IFN) result in hyperphosphorylation and delayed dephosphorylation of GOF STAT1. However, the mechanism how the delayed dephosphorylation exactly causes the increased expression of STAT1-dependent genes, and how the intracellular signal transduction from cytokine receptors is affected, remains unknown. Read More

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http://dx.doi.org/10.1002/eji.201847955DOI Listing
February 2019
2 Reads

Enhancing immunity prevents virus-induced T-cell-mediated immunopathology in B cell-deficient mice.

Eur J Immunol 2019 Feb 22. Epub 2019 Feb 22.

Institute for Immunology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.

Hyper-activated or deviated immune responses can result in immunopathological diseases. Paradoxically, immunodeficiency represents a frequent cause of such immune-mediated pathologies. Immunopathological manifestations are commonly treated by immunosuppression, but in situations in which immunodeficiency is the basis of disease development, enhancing immunity may represent an alternative treatment option. Read More

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http://dx.doi.org/10.1002/eji.201847962DOI Listing
February 2019

Arc/Arg3.1 defines dendritic cells and Langerhans cells with superior migratory ability independent of phenotype and ontogeny in mice.

Eur J Immunol 2019 Feb 20. Epub 2019 Feb 20.

Institut für Neuroimmunologie und Multiple Sklerose, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany.

The key function of migratory dendritic cells (migDCs) is to take up antigens in peripheral tissues and migrate to draining lymph nodes (dLN) to initiate immune responses. Recently, we discovered that in the mouse immune system activity-regulated cytoskeleton associated protein/activity-regulated gene 3.1 (Arc/Arg3. Read More

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http://dx.doi.org/10.1002/eji.201847797DOI Listing
February 2019

CCL21-expression and accumulation of CCR7 NK cells in livers of patients with primary sclerosing cholangitis.

Eur J Immunol 2019 Feb 20. Epub 2019 Feb 20.

Research Department of Virus Immunology, Heinrich Pette Institute, Hamburg, Germany.

The pathogenesis of primary sclerosing cholangitis (PSC), an autoimmune liver disease, remains unknown. The aim of this study was to characterize peripheral blood and intrahepatic NK cells from patients with PSC. Peripheral blood samples from patients with PSC, other autoimmune liver diseases, and from healthy control individuals were used, as well as liver tissues from PSC patients undergoing liver transplantation. Read More

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http://dx.doi.org/10.1002/eji.201847965DOI Listing
February 2019
3 Reads

Poly(I:C) stimulation is superior than Imiquimod to induce the antitumoral functional profile of tumor-conditioned macrophages.

Eur J Immunol 2019 Feb 18. Epub 2019 Feb 18.

Humanitas Clinical and Research Center IRCCS, Department of Innate Immunity and Inflammation, via Manzoni 56, 20089, Rozzano, Milan, Italy.

Macrophage plasticity is the ability of mononuclear phagocytes to change phenotype, function, and genetic reprogramming upon encounter of specific local stimuli. In the tumor microenvironment, Tumor-Associated Macrophages (TAMs) acquire an immune-suppressive and tumor-promoting phenotype. With the aim to re-educate TAMs to antitumor effectors, in this study, we used two immunestimulatory compounds: the TLR7 agonist Imiquimod (IMQ) and the TLR3 agonist Poly(I:C). Read More

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http://dx.doi.org/10.1002/eji.201847888DOI Listing
February 2019
8 Reads

Autophagy and immunological aberrations in systemic lupus erythematosus.

Eur J Immunol 2019 Apr 25;49(4):523-533. Epub 2019 Feb 25.

Renal Division, Peking University First Hospital, Peking University Institute of Nephrology, Key Laboratory of Renal Disease, Ministry of Health of China, Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education, Beijing, 100034, People's Republic of China.

Systemic lupus erythematosus (SLE) is a complex autoimmune disease, in which immune defects can occur at multiple points of the cascading auto-aggressive immune reactions, resulting in a striking heterogeneity of clinical presentations. The clinical manifestations of such autoimmune response can be severe: common manifestations symptoms include rash and renal inflammation progressing to kidney failure. Autophagy, the cellular "self-digestion" process, is a key factor in the interplay between innate and adaptive immunity. Read More

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http://doi.wiley.com/10.1002/eji.201847679
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http://dx.doi.org/10.1002/eji.201847679DOI Listing
April 2019
4 Reads
4.034 Impact Factor

Styk1 is specifically expressed in NK1.1 lymphocytes including NK, γδ T, and iNKT cells in mice, but is dispensable for their ontogeny and function.

Eur J Immunol 2019 Feb 13. Epub 2019 Feb 13.

Institute of Immunology, Hannover Medical School, Hannover, Germany.

Innate T cells, NK cells, and innate-like lymphocytes (ILCs) share transcriptional signatures that translate into overlapping developmental and functional programs. A prominent example for genes that are highly expressed in NK cells but not in ILCs is serine-threonine-tyrosine kinase 1 (Styk1 encoded by Styk1). We found Styk1 to be specifically expressed in lymphocytes positive for Killer cell lectin-like receptor subfamily B, member 1, also known as CD161 or NK1. Read More

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http://dx.doi.org/10.1002/eji.201848033DOI Listing
February 2019
3 Reads

Dnase1-deficient mice spontaneously develop a systemic lupus erythematosus-like disease.

Eur J Immunol 2019 Apr 21;49(4):590-599. Epub 2019 Feb 21.

Department of Cellular Microbiology, Max Planck Institute for Infection Biology, Berlin, Germany.

Systemic lupus erythematosus (SLE) is an autoimmune disease that has high morbidity and can result in multi-organ damage. SLE is characterized by dysregulated activation of T- and B-lymphocytes and the production of autoantibodies directed against nuclear components. The endonuclease deoxyribonuclease 1 (DNase1) is abundant in blood and a subset of SLE patients have mutations in DNASE1. Read More

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http://dx.doi.org/10.1002/eji.201847875DOI Listing
April 2019
2 Reads

Dendritic cells modulate c-kit expression on the edge between activation and death.

Eur J Immunol 2019 Apr 25;49(4):534-545. Epub 2019 Feb 25.

Institute of Molecular Biology and Pathology, National Research Council (CNR), Rome, Italy.

Dendritic cells (DCs) are key players in immunity and tolerance. Some DCs express c-kit, the receptor for stem cell factor (SCF), nevertheless c-kit functional role and the regulation of its expression in DCs are incompletely defined. We recently demonstrated that autocrine SCF sustains a pro-survival circuit, and that SCF increases phospho-AKT in c-kit+ mouse bone marrow-derived DCs (BMdDCs). Read More

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http://doi.wiley.com/10.1002/eji.201847683
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http://dx.doi.org/10.1002/eji.201847683DOI Listing
April 2019
7 Reads

Impressum.

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Eur J Immunol 2019 Feb;49(2):353

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http://dx.doi.org/10.1002/eji.201970026DOI Listing
February 2019

Croatian Immunological Society: Our half century.

Eur J Immunol 2019 Feb;49(2):208-211

Department for Histology and Embriology, University of Rijeka Faculty of Medicine, Braće Banchetta 20/1, 51000, Rijeka, Croatia.

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http://dx.doi.org/10.1002/eji.201970025DOI Listing
February 2019

Protection from EAE in DOCK8 mutant mice occurs despite increased Th17 cell frequencies in the periphery.

Eur J Immunol 2019 Feb 6. Epub 2019 Feb 6.

The John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia.

Mutation of Dedicator of cytokinesis 8 (DOCK8) has previously been reported to provide resistance to the Th17 cell dependent EAE in mice. Contrary to expectation, we observed an elevation of Th17 cells in two different DOCK8 mutant mouse strains in the steady state. This was specific for Th17 cells with no change in Th1 or Th2 cell populations. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/eji.20184796
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http://dx.doi.org/10.1002/eji.201847960DOI Listing
February 2019
7 Reads

CXCR4, but not CXCR3, drives CD8 T-cell entry into and migration through the murine bone marrow.

Eur J Immunol 2019 Apr 15;49(4):576-589. Epub 2019 Feb 15.

Department of Hematopoiesis, Sanquin Research and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

The BM serves as a blood-forming organ, but also supports the maintenance and immune surveillance function of many T cells. Yet, in contrast to other organs, little is known about the molecular mechanisms that drive T-cell migration to and localization inside the BM. As BM accumulates many CXCR3-expressing memory CD8 T cells, we tested the involvement of this chemokine receptor, but found that CXCR3 is not required for BM entry. Read More

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http://dx.doi.org/10.1002/eji.201747438DOI Listing
April 2019
2 Reads

Lipopolysaccharide impacts murine CD103 DC differentiation, altering the lung DC population balance.

Eur J Immunol 2019 Apr 12;49(4):638-652. Epub 2019 Feb 12.

Centre de Recherche, Institut Universitaire de Cardiologie et de Pneumologie de Québec, Université Laval, Québec, Canada.

Conventional DCs are a heterogeneous population that bridge the innate and adaptive immune systems. The lung DC population comprises CD103 XCR1 DC1s and CD11b DC2s; their various combined functions cover the whole spectrum of immune responses needed to maintain homeostasis. Here, we report that in vivo exposure to LPS leads to profound alterations in the proportions of CD103 XCR1 DCs in the lung. Read More

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http://dx.doi.org/10.1002/eji.201847910DOI Listing

Mannan-binding lectin attenuates acetaminophen-induced hepatotoxicity by regulating CYP2E1 expression via ROS-dependent JNK/SP1 pathway.

Eur J Immunol 2019 Apr 12;49(4):564-575. Epub 2019 Feb 12.

Department of Immunology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.

Mannan-binding lectin (MBL) acts as a soluble pattern recognition molecule in the innate immune system, which is primarily produced by the liver. MBL deficiency occurs with high frequency in the population and is reported to be associated with susceptibility to several liver diseases. In the present study, we investigated the pathophysiological role of MBL in acetaminophen (APAP)-induced hepatotoxicity. Read More

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http://dx.doi.org/10.1002/eji.201847830DOI Listing
April 2019
4 Reads

The contribution of active and passive mechanisms of 5mC and 5hmC removal in human T lymphocytes is differentiation- and activation-dependent.

Eur J Immunol 2019 Apr 8;49(4):611-625. Epub 2019 Feb 8.

Institute for Research in Biomedicine (IRB), Università della Svizzera italiana (USI), Bellinzona, Switzerland.

In mammals, the 5'-methylcytosine (5mC) modification in the genomic DNA contributes to the dynamic control of gene expression. 5mC erasure is required for the activation of developmental programs and occurs either by passive dilution through DNA replication, or by enzymatic oxidation of the methyl mark to 5-hydroxymethylcytosine (5hmC), which can persist as such or undergo further oxidation and enzymatic removal. The relative contribution of each mechanism to epigenetic control in dynamic biological systems still remains a compelling question. Read More

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http://dx.doi.org/10.1002/eji.201847967DOI Listing
April 2019
1 Read

IL-10 promotes malignant pleural effusion in mice by regulating T 1- and T 17-cell differentiation and migration.

Eur J Immunol 2019 Apr 12;49(4):653-665. Epub 2019 Feb 12.

Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.

The role of IL-10 in malignant pleural effusion (MPE) remains unknown. By using murine MPE models, we observed that an increase in pleural IL-10 was a significant predictor of increased risk of death. We noted that T 1- and T 17-cell content in MPE was higher in IL-10 mice than in WT mice, and IL-10 deficiency promoted differentiation into T 1 but not into T 17 cells. Read More

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http://dx.doi.org/10.1002/eji.201847685DOI Listing
April 2019
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Styk1 expression is a hallmark of murine NK cells and other NK1.1 subsets but is dispensable for NK-cell development and effector functions.

Eur J Immunol 2019 Jan 28. Epub 2019 Jan 28.

CIRI, Centre International de Recherche en Infectiologie - International Center for Infectiology Research, Lyon, France.

To gain insight into the biology of NK cells, others and we previously identified the NK-cell signature, defined as the set of transcripts which expression is highly enriched in these cells compared to other immune subtypes. The transcript encoding the Serine/threonine/tyrosine kinase 1 (Styk1) is part of this signature. However, the role of Styk1 in the immune system is unknown. Read More

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http://dx.doi.org/10.1002/eji.201847721DOI Listing
January 2019
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CD69 memory T lymphocytes of the bone marrow and spleen express the signature transcripts of tissue-resident memory T lymphocytes.

Eur J Immunol 2019 Jan 23. Epub 2019 Jan 23.

Cell Biology, Deutsches Rheuma-Forschungszentrum Berlin (DRFZ), a Leibniz Institute, Berlin, Germany.

It is a matter of current debate whether the bone marrow is a hub for circulating memory T lymphocytes and/or the home of resident memory T lymphocytes. Here we demonstrate for CD69 murine CD8 , and CD69 murine and human CD4 memory T lymphocytes of the bone marrow, making up between 30 and 60% of bone marrow memory T lymphocytes, that they express the gene expression signature of tissue-resident memory T lymphocytes. This suggests that a substantial proportion of bone marrow memory T lymphocytes are resident. Read More

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http://dx.doi.org/10.1002/eji.201847982DOI Listing
January 2019

Impaired antigen-specific lymphocyte priming in mice after Toll-like receptor 4 activation via induction of monocytic myeloid-derived suppressor cells.

Eur J Immunol 2019 Apr 1;49(4):546-563. Epub 2019 Feb 1.

Laboratory of Oncology, Pharmacy Practice and Sciences, Graduate School of Pharmaceutical Sciences, Tohoku University, Aramaki, Sendai, Japan.

In sepsis, the pathology involves a shift from a proinflammatory state toward an immunosuppressive phase. We previously showed that an agonistic anti-TLR4 antibody induced long-term endotoxin tolerance and suppressed antigen-specific secondary IgG production when primed prior to immunization with antigen. These findings led us to speculate that TLR4-induced innate tolerance due to primary infection causes an immunosuppressive pathology in sepsis. Read More

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http://dx.doi.org/10.1002/eji.201847805DOI Listing
April 2019
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TLR signals license CD8 T cells to destroy oligodendrocytes expressing an antigen shared with a Listeria pathogen.

Eur J Immunol 2019 Mar 11;49(3):413-427. Epub 2019 Feb 11.

Department of Neuropathology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.

Increasing evidence suggests a role of CD8 T cells in autoimmune demyelinating CNS disease, which, however, is still controversially discussed. Mice, which express ovalbumin (OVA) as cytosolic self-antigen in oligodendrocytes (ODC-OVA mice), respond to CNS infection induced by OVA-expressing attenuated Listeria with CD8 T cell-mediated inflammatory demyelination. This model is suitable to decipher the contribution of CD8 T cells and the pathogen in autoimmune CNS disease. Read More

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http://doi.wiley.com/10.1002/eji.201847834
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http://dx.doi.org/10.1002/eji.201847834DOI Listing
March 2019
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Transformation of mature mouse B cells into malignant plasma cells in vitro via introduction of defined genetic elements.

Eur J Immunol 2019 Mar 4;49(3):454-461. Epub 2019 Feb 4.

Center for Hematology and Regenerative Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm, Sweden.

An experimental system where defined alterations in gene function or gene expression levels in primary B cells would result in the development of transformed plasma cells in vitro would be useful in order to facilitate studies of the underlying molecular mechanisms of plasma cell malignancies. Here, such a system is described in which primary murine B cells rapidly become transformed into surface CD138 , IgM , CD19 IgM-secreting plasma cells as a result of expression of the transcription factors IRF4 and MYC together with simultaneous expression of BMI1, mutated p53 or silencing of p19 , and suppression of intrinsic apoptosis through expression of BCLXL. Analysis of gene expression patterns revealed that this combination of transforming genes resulted in expression of a number of genes previously associated with terminally differentiated B cells (plasma cells) and myeloma cells, whereas many genes associated with mature B cells and B-cell lymphomas were not expressed. Read More

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http://dx.doi.org/10.1002/eji.201847855DOI Listing
March 2019
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Soluble CD93 is an apoptotic cell opsonin recognized by α β.

Eur J Immunol 2019 Apr 7;49(4):600-610. Epub 2019 Feb 7.

Department of Microbiology and Immunology, Center for Human Immunology, The University of Western Ontario, London, Ontario, Canada.

Efferocytosis is essential for homeostasis and prevention of the inflammatory and autoimmune diseases resulting from apoptotic cell lysis. CD93 is a transmembrane glycoprotein previously implicated in efferocytosis, with mutations in CD93 predisposing patients to efferocytosis-associated diseases. CD93 is a cell surface protein, which is proteolytically shed under inflammatory conditions, but it is unknown how CD93 mediates efferocytosis or whether its efferocytic activity is mediated by the soluble or membrane-bound form. Read More

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http://doi.wiley.com/10.1002/eji.201847801
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http://dx.doi.org/10.1002/eji.201847801DOI Listing
April 2019
16 Reads