15,304 results match your criteria European Journal of Immunology [Journal]


Enhancing immunity prevents virus-induced T cell-mediated immunopathology in B cell-deficient mice.

Eur J Immunol 2019 Feb 22. Epub 2019 Feb 22.

Institute for Immunology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.

Hyper-activated or deviated immune responses can result in immunopathological diseases. Paradoxically, immunodeficiency represents a frequent cause of such immune-mediated pathologies. Immunopathological manifestations are commonly treated by immunosuppression, but in situations in which immunodeficiency is the basis of disease development, enhancing immunity may represent an alternative treatment option. Read More

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http://dx.doi.org/10.1002/eji.201847962DOI Listing
February 2019

Arc/Arg3.1 defines dendritic cells and Langerhans cells with superior migratory ability independent of phenotype and ontogeny in mice.

Eur J Immunol 2019 Feb 20. Epub 2019 Feb 20.

Institut für Neuroimmunologie und Multiple Sklerose, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany.

The key function of migratory dendritic cells (migDCs) is to take up antigens in peripheral tissues and migrate to draining lymph nodes (dLN) to initiate immune responses. Recently, we discovered that in the mouse immune system activity-regulated cytoskeleton associated protein/activity-regulated gene 3.1 (Arc/Arg3. Read More

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http://dx.doi.org/10.1002/eji.201847797DOI Listing
February 2019

CCL21-expression and accumulation of CCR7 NK cells in livers of patients with primary sclerosing cholangitis.

Eur J Immunol 2019 Feb 20. Epub 2019 Feb 20.

Research Department of Virus Immunology, Heinrich Pette Institute, Hamburg, Germany.

The pathogenesis of primary sclerosing cholangitis (PSC), an autoimmune liver disease, remains unknown. The aim of this study was to characterize peripheral blood and intrahepatic NK cells from patients with PSC. Peripheral blood samples from patients with PSC, other autoimmune liver diseases, and from healthy control individuals were used, as well as liver tissues from PSC patients undergoing liver transplantation. Read More

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http://dx.doi.org/10.1002/eji.201847965DOI Listing
February 2019

Poly(I:C) stimulation is superior than Imiquimod to induce the anti-tumoral functional profile of tumor-conditioned macrophages.

Eur J Immunol 2019 Feb 18. Epub 2019 Feb 18.

IRCCS Clinical and Research Institute Humanitas, Via A. Manzoni 113, 20089, Rozzano, Milan, Italy.

Macrophage plasticity is the ability of mononuclear phagocytes to change phenotype, function and genetic re-programming upon encounter of specific local stimuli. In the tumor micro-environment, Tumor-Associated Macrophages (TAMs) acquire an immune-suppressive and tumor-promoting phenotype. With the aim to re-educate TAMs to anti-tumor effectors, in this study we used two immune-stimulatory compounds: the TLR7 agonist Imiquimod (IMQ) and the TLR3 agonist Poly(I:C). Read More

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http://dx.doi.org/10.1002/eji.201847888DOI Listing
February 2019

Autophagy and immunological aberrations in systemic lupus erythematosus.

Eur J Immunol 2019 Feb 18. Epub 2019 Feb 18.

Renal Division, Peking University First Hospital, Peking University Institute of Nephrology, Key Laboratory of Renal Disease, Ministry of Health of China, Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education, Beijing, 100034, People's Republic of China.

Systemic lupus erythematosus (SLE) is a complex autoimmune disease, in which immune defects can occur at multiple points of the cascading auto-aggressive immune reactions, resulting in a striking heterogeneity of clinical presentations. The clinical manifestations of such autoimmune response can be severe:-common manifestations symptoms include rash and renal inflammation progressing to kidney failure. Autophagy, the cellular "self-digestion" process, is a key factor in the interplay between innate and adaptive immunity. Read More

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http://doi.wiley.com/10.1002/eji.201847679
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http://dx.doi.org/10.1002/eji.201847679DOI Listing
February 2019
4 Reads

Styk1 is specifically expressed in NK1.1 lymphocytes including NK, γδ T, and iNKT cells in mice, but is dispensable for their ontogeny and function.

Eur J Immunol 2019 Feb 13. Epub 2019 Feb 13.

Institute of Immunology, Hannover Medical School, Hannover, Germany.

Innate T cells, NK cells, and innate-like lymphocytes (ILCs) share transcriptional signatures that translate into overlapping developmental and functional programs. A prominent example for genes that are highly expressed in NK cells but not in ILCs is serine-threonine-tyrosine kinase 1 (Styk1 encoded by Styk1). We found Styk1 to be specifically expressed in lymphocytes positive for Killer cell lectin-like receptor subfamily B, member 1, also known as CD161 or NK1. Read More

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http://dx.doi.org/10.1002/eji.201848033DOI Listing
February 2019
1 Read

Dnase1-deficient mice spontaneously develop a systemic lupus erythematosus-like disease.

Eur J Immunol 2019 Feb 13. Epub 2019 Feb 13.

Department of Cellular Microbiology, Max Planck Institute for Infection Biology, Berlin, Germany.

Systemic lupus erythematosus (SLE) is an autoimmune disease that has high morbidity and can result in multi-organ damage. SLE is characterized by dysregulated activation of T- and B-lymphocytes and the production of autoantibodies directed against nuclear components. The endonuclease deoxyribonuclease 1 (DNase1) is abundant in blood and a subset of SLE patients have mutations in DNASE1. Read More

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http://dx.doi.org/10.1002/eji.201847875DOI Listing
February 2019
1 Read

Dendritic Cells modulate c-kit expression on the edge between activation and death.

Eur J Immunol 2019 Feb 13. Epub 2019 Feb 13.

Institute of Molecular Biology and Pathology, National Research Council (CNR), Rome, Italy.

Dendritic cells (DCs) are key players in immunity and tolerance. Some DCs express c-kit, the receptor for Stem Cell Factor (SCF), nevertheless c-kit functional role and the regulation of its expression in DCs are incompletely defined. We recently demonstrated that autocrine SCF sustains a pro-survival circuit, and that SCF increases phospho-AKT in c-kit+ mouse Bone Marrow-derived DCs (BMdDCs). Read More

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http://doi.wiley.com/10.1002/eji.201847683
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http://dx.doi.org/10.1002/eji.201847683DOI Listing
February 2019
1 Read

Impressum.

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Eur J Immunol 2019 Feb;49(2):353

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http://dx.doi.org/10.1002/eji.201970026DOI Listing
February 2019

Croatian Immunological Society: Our half century.

Eur J Immunol 2019 Feb;49(2):208-211

Department for Histology and Embriology, University of Rijeka Faculty of Medicine, Braće Banchetta 20/1, 51000, Rijeka, Croatia.

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http://dx.doi.org/10.1002/eji.201970025DOI Listing
February 2019

Protection from EAE in DOCK8 mutant mice occurs despite increased Th17 cell frequencies in the periphery.

Eur J Immunol 2019 Feb 6. Epub 2019 Feb 6.

The John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia.

Mutation of Dedicator of cytokinesis 8 (DOCK8) has previously been reported to provide resistance to the Th17 cell dependent EAE in mice. Contrary to expectation, we observed an elevation of Th17 cells in two different DOCK8 mutant mouse strains in the steady state. This was specific for Th17 cells with no change in Th1 or Th2 cell populations. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/eji.20184796
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http://dx.doi.org/10.1002/eji.201847960DOI Listing
February 2019
2 Reads

CXCR4, but not CXCR3, drives CD8 T-cell entry into and migration through the murine bone marrow.

Eur J Immunol 2019 Feb 1. Epub 2019 Feb 1.

Department of Hematopoiesis, Sanquin Research and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

The BM serves as a blood-forming organ, but also supports the maintenance and immune surveillance function of many T cells. Yet, in contrast to other organs, little is known about the molecular mechanisms that drive T-cell migration to and localization inside the BM. As BM accumulates many CXCR3-expressing memory CD8 T cells, we tested the involvement of this chemokine receptor, but found that CXCR3 is not required for BM entry. Read More

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http://dx.doi.org/10.1002/eji.201747438DOI Listing
February 2019

Lipopolysaccharide impacts murine CD103 DC differentiation, altering the lung DC population balance.

Eur J Immunol 2019 Feb 1. Epub 2019 Feb 1.

Centre de Recherche, Institut Universitaire de Cardiologie et de Pneumologie de Québec, Université Laval, Québec, Canada.

Conventional DCs are a heterogeneous population that bridge the innate and adaptive immune systems. The lung DC population comprises CD103 XCR1 DC1s and CD11b DC2s; their various combined functions cover the whole spectrum of immune responses needed to maintain homeostasis. Here, we report that in vivo exposure to LPS leads to profound alterations in the proportions of CD103 XCR1 DCs in the lung. Read More

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http://dx.doi.org/10.1002/eji.201847910DOI Listing
February 2019

Mannan-binding lectin attenuates acetaminophen-induced hepatotoxicity by regulating CYP2E1 expression via ROS-dependent JNK/SP1 pathway.

Eur J Immunol 2019 Feb 1. Epub 2019 Feb 1.

Department of Immunology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.

Mannan-binding lectin (MBL) acts as a soluble pattern recognition molecule in the innate immune system, which is primarily produced by the liver. MBL deficiency occurs with high frequency in the population and is reported to be associated with susceptibility to several liver diseases. In the present study, we investigated the pathophysiological role of MBL in acetaminophen (APAP)-induced hepatotoxicity. Read More

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http://dx.doi.org/10.1002/eji.201847830DOI Listing
February 2019
1 Read

The contribution of active and passive mechanisms of 5mC and 5hmC removal in human T lymphocytes is differentiation- and activation-dependent.

Eur J Immunol 2019 Jan 30. Epub 2019 Jan 30.

Institute for Research in Biomedicine (IRB), Università della Svizzera italiana (USI), Bellinzona, Switzerland.

In mammals, the 5'-methylcytosine (5mC) modification in the genomic DNA contributes to the dynamic control of gene expression. 5mC erasure is required for the activation of developmental programs and occurs either by passive dilution through DNA replication, or by enzymatic oxidation of the methyl mark to 5-hydroxymethylcytosine (5hmC), which can persist as such or undergo further oxidation and enzymatic removal. The relative contribution of each mechanism to epigenetic control in dynamic biological systems still remains a compelling question. Read More

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http://dx.doi.org/10.1002/eji.201847967DOI Listing
January 2019

IL-10 promotes malignant pleural effusion in mice by regulating T 1- and T 17-cell differentiation and migration.

Eur J Immunol 2019 Jan 29. Epub 2019 Jan 29.

Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.

The role of IL-10 in malignant pleural effusion (MPE) remains unknown. By using murine MPE models, we observed that an increase in pleural IL-10 was a significant predictor of increased risk of death. We noted that T 1- and T 17-cell content in MPE was higher in IL-10 mice than in WT mice, and IL-10 deficiency promoted differentiation into T 1 but not into T 17 cells. Read More

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http://dx.doi.org/10.1002/eji.201847685DOI Listing
January 2019
1 Read
4.034 Impact Factor

Styk1 expression is a hallmark of murine NK cells and other NK1.1 subsets but is dispensable for NK-cell development and effector functions.

Eur J Immunol 2019 Jan 28. Epub 2019 Jan 28.

CIRI, Centre International de Recherche en Infectiologie - International Center for Infectiology Research, Lyon, France.

To gain insight into the biology of NK cells, others and we previously identified the NK-cell signature, defined as the set of transcripts which expression is highly enriched in these cells compared to other immune subtypes. The transcript encoding the Serine/threonine/tyrosine kinase 1 (Styk1) is part of this signature. However, the role of Styk1 in the immune system is unknown. Read More

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http://dx.doi.org/10.1002/eji.201847721DOI Listing
January 2019

CD69 memory T lymphocytes of the bone marrow and spleen express the signature transcripts of tissue-resident memory T lymphocytes.

Eur J Immunol 2019 Jan 23. Epub 2019 Jan 23.

Cell Biology, Deutsches Rheuma-Forschungszentrum Berlin (DRFZ), a Leibniz Institute, Berlin, Germany.

It is a matter of current debate whether the bone marrow is a hub for circulating memory T lymphocytes and/or the home of resident memory T lymphocytes. Here we demonstrate for CD69 murine CD8 , and CD69 murine and human CD4 memory T lymphocytes of the bone marrow, making up between 30 and 60% of bone marrow memory T lymphocytes, that they express the gene expression signature of tissue-resident memory T lymphocytes. This suggests that a substantial proportion of bone marrow memory T lymphocytes are resident. Read More

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http://dx.doi.org/10.1002/eji.201847982DOI Listing
January 2019

Impaired antigen-specific lymphocyte priming in mice after Toll-like receptor 4 activation via induction of monocytic myeloid-derived suppressor cells.

Eur J Immunol 2019 Jan 22. Epub 2019 Jan 22.

Laboratory of Oncology, Pharmacy Practice and Sciences, Graduate School of Pharmaceutical Sciences, Tohoku University, Aramaki, Sendai, Japan.

In sepsis, the pathology involves a shift from a proinflammatory state toward an immunosuppressive phase. We previously showed that an agonistic anti-TLR4 antibody induced long-term endotoxin tolerance and suppressed antigen-specific secondary IgG production when primed prior to immunization with antigen. These findings led us to speculate that TLR4-induced innate tolerance due to primary infection causes an immunosuppressive pathology in sepsis. Read More

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http://dx.doi.org/10.1002/eji.201847805DOI Listing
January 2019

TLR signals license CD8 T cells to destroy oligodendrocytes expressing an antigen shared with a Listeria pathogen.

Eur J Immunol 2019 Jan 22. Epub 2019 Jan 22.

Department of Neuropathology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.

Increasing evidence suggests a role of CD8 T cells in autoimmune demyelinating CNS disease, which, however, is still controversially discussed. Mice, which express ovalbumin (OVA) as cytosolic self-antigen in oligodendrocytes (ODC-OVA mice), respond to CNS infection induced by OVA-expressing attenuated Listeria with CD8 T cell-mediated inflammatory demyelination. This model is suitable to decipher the contribution of CD8 T cells and the pathogen in autoimmune CNS disease. Read More

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http://doi.wiley.com/10.1002/eji.201847834
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http://dx.doi.org/10.1002/eji.201847834DOI Listing
January 2019
4 Reads

Transformation of mature mouse B cells into malignant plasma cells in vitro via introduction of defined genetic elements.

Eur J Immunol 2019 Jan 21. Epub 2019 Jan 21.

Center for Hematology and Regenerative Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm, Sweden.

An experimental system where defined alterations in gene function or gene expression levels in primary B cells would result in the development of transformed plasma cells in vitro would be useful in order to facilitate studies of the underlying molecular mechanisms of plasma cell malignancies. Here, such a system is described in which primary murine B cells rapidly become transformed into surface CD138 , IgM , CD19 IgM-secreting plasma cells as a result of expression of the transcription factors IRF4 and MYC together with simultaneous expression of BMI1, mutated p53 or silencing of p19 , and suppression of intrinsic apoptosis through expression of BCLXL. Analysis of gene expression patterns revealed that this combination of transforming genes resulted in expression of a number of genes previously associated with terminally differentiated B cells (plasma cells) and myeloma cells, whereas many genes associated with mature B cells and B-cell lymphomas were not expressed. Read More

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http://dx.doi.org/10.1002/eji.201847855DOI Listing
January 2019
1 Read

Soluble CD93 is an apoptotic cell opsonin recognized by α β.

Eur J Immunol 2019 Jan 18. Epub 2019 Jan 18.

Department of Microbiology and Immunology, Center for Human Immunology, The University of Western Ontario, London, Ontario, Canada.

Efferocytosis is essential for homeostasis and prevention of the inflammatory and autoimmune diseases resulting from apoptotic cell lysis. CD93 is a transmembrane glycoprotein previously implicated in efferocytosis, with mutations in CD93 predisposing patients to efferocytosis-associated diseases. CD93 is a cell surface protein, which is proteolytically shed under inflammatory conditions, but it is unknown how CD93 mediates efferocytosis or whether its efferocytic activity is mediated by the soluble or membrane-bound form. Read More

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http://doi.wiley.com/10.1002/eji.201847801
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http://dx.doi.org/10.1002/eji.201847801DOI Listing
January 2019
11 Reads

The end of omics? High dimensional single cell analysis in precision medicine.

Eur J Immunol 2019 Feb 25;49(2):212-220. Epub 2019 Jan 25.

Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland.

High-dimensional single-cell (HDcyto) technologies, such as mass cytometry (CyTOF) and flow cytometry, are the key techniques that hold a great promise for deciphering complex biological processes. During the last decade, we witnessed an exponential increase of novel HDcyto technologies that are able to deliver an in-depth profiling in different settings, such as various autoimmune diseases and cancer. The concurrent advance of custom data-mining algorithms has provided a rich substrate for the development of novel tools in translational medicine research. Read More

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http://dx.doi.org/10.1002/eji.201847758DOI Listing
February 2019
1 Read

Residual LCMV antigen in transiently CD4 T cell-depleted mice induces high levels of virus-specific antibodies but only limited B-cell memory.

Eur J Immunol 2019 Jan 12. Epub 2019 Jan 12.

Institute for Immunology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.

Infection of C57BL/6 mice with lymphocytic choriomeningitis virus (LCMV) strain Armstrong (Arm) induces an acute infection with rapid virus clearance by CD8 T cells independently of CD4 T cell help. Residual viral antigen may, however, persist for a prolonged time. Here, we demonstrate that mice that had been transiently depleted of CD4 T cells during acute LCMV Arm infection generated high levels of virus-specific IgG antibodies (Ab) after viral clearance. Read More

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http://dx.doi.org/10.1002/eji.201847772DOI Listing
January 2019
2 Reads

Untangling "NETosis" from NETs.

Eur J Immunol 2019 Feb 15;49(2):221-227. Epub 2019 Jan 15.

Institute of Pharmacology, University of Bern, Bern, Switzerland.

Neutrophil extracellular trap (NET) formation is a cellular function of neutrophils that facilitates the immobilization and killing of invading microorganisms in the extracellular milieu. To form NETs, neutrophils release a DNA scaffold consisting of mitochondrial DNA binding granule proteins. This process does not depend on cell death, but requires glycolytic ATP production for rearrangements in the microtubule network and F-actin. Read More

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http://dx.doi.org/10.1002/eji.201747053DOI Listing
February 2019
1 Read

Helios and Helios Treg subpopulations are phenotypically and functionally distinct and express dissimilar TCR repertoires.

Eur J Immunol 2019 Jan 8. Epub 2019 Jan 8.

Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

The transcription factor Helios is expressed in a large subset of Foxp3 Tregs. We previously proposed that Helios is a marker of thymic derived Treg (tTreg), while Helios Treg were induced from Foxp3 T conventional (Tconv) cells in the periphery (pTreg). To compare the two Treg subpopulations, we generated Helios-GFP reporter mice and crossed them to Foxp3-RFP reporter mice. Read More

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http://doi.wiley.com/10.1002/eji.201847935
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http://dx.doi.org/10.1002/eji.201847935DOI Listing
January 2019
9 Reads
4.034 Impact Factor

Impressum.

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Eur J Immunol 2019 Jan;49(1):199

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http://dx.doi.org/10.1002/eji.201970016DOI Listing
January 2019
1 Read

Advancing the therapeutic potential of the IL-1 family in inflammatory diseases - Meeting report.

Eur J Immunol 2019 Jan;49(1):8-10

National Childrens Research Centre, Our Ladys Childrens Hospital Crumlin, Dublin, Ireland.

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http://dx.doi.org/10.1002/eji.201970015DOI Listing
January 2019
1 Read

XIAP deficiency in hematopoietic recipient cells drives donor T-cell activation and GvHD in mice.

Eur J Immunol 2018 Dec 25. Epub 2018 Dec 25.

Medizinische Klinik III, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.

Patients with X-linked lymphoproliferative syndrome type 2 (XLP-2) (BIRC4 deficiency) suffer from hyperinflammation often observed during the conditioning regimen prior to allogeneic bone marrow transplant. This article shows that in mice hematopoietic recipient cells contribute to graft-versus-host disease by the secretion of elevated levels of proinflammatory cytokines during engraftment when BIRC4 is absent. Read More

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http://dx.doi.org/10.1002/eji.201847818DOI Listing
December 2018
2 Reads

B mouse: A novel transgenic mouse strain to track and deplete B cells.

Eur J Immunol 2018 Dec 22. Epub 2018 Dec 22.

Research group Neuroinflammation and Mucosal Immunology, Max Planck Institute of Biochemistry, Martinsried, Germany.

B mice express a red fluorescent protein together with the diphtheria toxin receptor selectively in B cells. B cells can be effectively visualized by red fluorescence and can be efficiently depleted in a highly controlled fashion to study their functional capacity in vivo. Read More

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http://dx.doi.org/10.1002/eji.201847930DOI Listing
December 2018
2 Reads

High-dimensional single-cell proteomics analysis identifies immune checkpoint signatures and therapeutic targets in ulcerative colitis.

Eur J Immunol 2018 Dec 22. Epub 2018 Dec 22.

Roche Pharma Research and Early Development, Immunology, Inflammation and Infectious Diseases (I3) Discovery and Translational Area, Roche Innovation Center Basel, Basel, Switzerland.

Immune checkpoints are regulators of immune cells and play key roles in the modulation of immune responses. The role of checkpoints in autoimmune disease is poorly understood but likely to be central since checkpoint inhibition during cancer treatment can cause autoimmunity. We generated a high-dimensional single-cell proteomics data set from PBMCs of healthy individuals and patients with ulcerative colitis (UC) by mass cytometry, enabling systems-wide analyses of immune cell frequencies and cell type-specific expression patterns of 12 immune checkpoints. Read More

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http://doi.wiley.com/10.1002/eji.201847862
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http://dx.doi.org/10.1002/eji.201847862DOI Listing
December 2018
4 Reads

ID2 and ID3 are indispensable for Th1 cell differentiation during influenza virus infection in mice.

Eur J Immunol 2018 Dec 22. Epub 2018 Dec 22.

CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing, China.

Antigen-specific Th1 cells could be a passage to the infection sites during infection to execute effector functions, such as help CD8 T cells to localize in these sites by secretion of anti-viral cytokines-IFN-γ or direct cytotoxicity of antigen-bearing cells. However, the molecular components that modulate Th1 cell differentiation and function in response to viral infection remain incompletely understood. Here, we reported that both inhibitor of DNA binding 3(Id3) protein and inhibitor of DNA binding 2(Id2) protein promoted Th1 cell differentiation. Read More

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http://dx.doi.org/10.1002/eji.201847822DOI Listing
December 2018
1 Read

Activation of integrated stress response pathway regulates IL-1β production through posttranscriptional and translational reprogramming in macrophages.

Eur J Immunol 2019 Feb 4;49(2):277-289. Epub 2019 Jan 4.

Department of Biotechnology and Bioinformatics, School of Life Sciences, University of Hyderabad, Hyderabad, India.

Immune cells sense and programme its cellular machinery appropriately to the environmental changes through the activation of cytoprotective adaptive pathway so-called the "integrated stress response (ISR)". However, the mechanisms implicated in ISR-induced protective responses are poorly understood. Here, we show that ISR activation by arsenite (Ar) results in suppression of IL-1β production in macrophages and inhibition of DSS-induced colitis in a murine model through a novel posttranscriptional and translation regulatory (PTR) mechanism. Read More

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http://doi.wiley.com/10.1002/eji.201847513
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http://dx.doi.org/10.1002/eji.201847513DOI Listing
February 2019
8 Reads
4.034 Impact Factor

IL-4 promotes stromal cell expansion and is critical for development of a type-2, but not a type 1 immune response.

Eur J Immunol 2018 Dec 21. Epub 2018 Dec 21.

Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, IN, USA.

IL-4 is critical for differentiation of Th2 cells and antibody isotype switching, but our work demonstrated that it is produced in the peripheral LN under both Type 2, and Type 1 conditions, raising the possibility of other functions. We found that IL-4 is vital for proper positioning of hematopoietic and stromal cells in steady state, and the lack of IL-4 or IL-4Rα correlates with disarrangement of both follicular dendritic cells and CD31 endothelial cells. We observed a marked disorganization of B cells in these mice, suggesting that the lymphocyte-stromal cell axis is maintained by the IL-4 signaling pathway. Read More

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http://dx.doi.org/10.1002/eji.201847789DOI Listing
December 2018
1 Read

Characterization of regulatory T cells in obese omental adipose tissue in humans.

Eur J Immunol 2019 Feb 8;49(2):336-347. Epub 2019 Jan 8.

Department of Surgery, University of British Columbia, Vancouver, BC, Canada.

Obesity-associated visceral adipose tissue (AT) inflammation promotes insulin resistance and type 2 diabetes (T2D). In mice, lean visceral AT is populated with anti-inflammatory cells, notably regulatory T cells (Tregs) expressing the IL-33 receptor ST2. Conversely, obese AT contains fewer Tregs and more proinflammatory cells. Read More

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http://dx.doi.org/10.1002/eji.201847570DOI Listing
February 2019
1 Read
4.034 Impact Factor

IL-10 signaling in dendritic cells is required for tolerance induction in a murine model of allergic airway inflammation.

Eur J Immunol 2019 Feb 3;49(2):302-312. Epub 2019 Jan 3.

Allergy Research Group, Department of Dermatology, Medical Center, University of Freiburg, Freiburg, Germany.

Allergen specific tolerance induction efficiently ameliorates subsequent allergen induced inflammatory responses. The underlying regulatory mechanisms have been attributed mainly to interleukin (IL)-10 produced by diverse hematopoietic cells, while targets of IL-10 in allergen specific tolerance induction have not yet been well defined. Here, we investigate potential cellular targets of IL-10 in allergen specific tolerance induction using mice with a cell type specific inactivation of the IL-10 receptor gene. Read More

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http://dx.doi.org/10.1002/eji.201847883DOI Listing
February 2019
1 Read
4.034 Impact Factor

Anti-EF-Tu IgG titers increase with age and may contribute to protection against the respiratory pathogen Haemophilus influenzae.

Eur J Immunol 2018 Dec 19. Epub 2018 Dec 19.

Clinical Microbiology, Department of Translational Medicine, Faculty of Medicine, Lund University, Malmö, Sweden.

Non-typeable Haemophilus influenzae (NTHi) is a pathogen that commonly colonizes the nasopharynx of preschool children, causing opportunistic infections including acute otitis media (AOM). Patients suffering from chronic obstructive pulmonary disease (COPD) are persistently colonized with NTHi and occasionally suffer from exacerbations by the bacterium leading to increased morbidity. Elongation-factor thermo unstable (EF-Tu), a protein critical for bacterial protein synthesis, has been found to moonlight on the surface of several bacteria. Read More

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http://dx.doi.org/10.1002/eji.201847871DOI Listing
December 2018
3 Reads

Invariant natural killer T cells stimulated with cholesteryl glycosides modulate immune responses in allergy and delayed-type hypersensitivity.

Eur J Immunol 2019 Feb 4;49(2):348-350. Epub 2019 Jan 4.

School of Biosciences, University of Birmingham, Birmingham, United Kingdom.

Invariant NKT cells were stimulated with cholesteryl O-acyl α-glycosides in the context of CD1d. The activated NKT cells have potential to sustain the homeostasis in the body exposed to excess in either Th1- or Th2-immunity. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/eji.20184782
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http://dx.doi.org/10.1002/eji.201847825DOI Listing
February 2019
3 Reads

Memory CD4 T cells enhance B-cell responses to drifting influenza immunization.

Eur J Immunol 2019 Feb 21;49(2):266-276. Epub 2018 Dec 21.

Infectious Disease Research Institute, Seattle, WA, USA.

Influenza A annually infects 5-10% of the world's human population resulting in one million deaths. Influenza causes annual epidemics and reinfects previously exposed individuals because of antigenic drift in the glycoprotein hemagglutinin. Due to antigenic drift, the immune system is simultaneously exposed to novel and conserved parts of the influenza virus via vaccination and/or infection throughout life. Read More

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http://dx.doi.org/10.1002/eji.201847852DOI Listing
February 2019
1 Read

HMGB1 microparticles present in urine are hallmarks of nephritis in patients with systemic lupus erythematosus.

Eur J Immunol 2019 Feb 7;49(2):323-335. Epub 2019 Jan 7.

Grupo de Inmunología Celular e Inmunogenética, Instituto de Investigaciones Médicas, Facultad de Medicina, Universidad de Antioquia UdeA, Medellín, Colombia.

Non-classical monocytes infiltrate the kidney parenchyma and participate in tissue damage in patients with lupus nephritis (LN). Circulating microparticles (MPs) seem to play critical roles in the activation of monocytes in systemic lupus erythematosus (SLE) patients. This study aims to characterize the phenotypes of MPs and monocyte subsets in LN patients and to determine their potential to discriminate between SLE patients with and without LN. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/eji.20184774
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http://dx.doi.org/10.1002/eji.201847747DOI Listing
February 2019
7 Reads

Expression of Plet1 controls interstitial migration of murine small intestinal dendritic cells.

Eur J Immunol 2019 Feb 14;49(2):290-301. Epub 2018 Dec 14.

Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands.

Under homeostatic conditions, dendritic cells (DCs) continuously patrol the intestinal lamina propria. Upon antigen encounter, DCs initiate C-C motif chemokine receptor 7 (CCR7) expression and migrate into lymph nodes to direct T cell activation and differentiation. The mechanistic underpinnings of DC migration from the tissues to lymph nodes have been largely elucidated, contributing greatly to our understanding of DC functionality and intestinal immunity. Read More

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http://dx.doi.org/10.1002/eji.201847671DOI Listing
February 2019
4 Reads

Human anti-NKp46 antibody for studies of NKp46-dependent NK cell function and its applications for type 1 diabetes and cancer research.

Eur J Immunol 2019 Feb 17;49(2):228-241. Epub 2018 Dec 17.

The Concern Foundation Laboratories at the Lautenberg Center for Immunology and Cancer Research, The BioMedical Research Institute Israel Canada of the Faculty of Medicine (IMRIC), The Hebrew University Hadassah Medical School, Jerusalem, Israel.

Natural killer (NK) cells are innate lymphocytes that efficiently eliminate cancerous and infected cells. NKp46 is an important NK activating receptor shown to participate in recognition and activation of NK cells against pathogens, tumor cells, virally infected cells, and self-cells in autoimmune conditions, including type I and II diabetes. However, some of the NKp46 ligands are unknown and therefore investigating human NKp46 activity and its critical role in NK cell biology is problematic. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/eji.20184761
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http://dx.doi.org/10.1002/eji.201847611DOI Listing
February 2019
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The role of Eomes in human CD4 T cell differentiation: A question of context.

Eur J Immunol 2019 Jan;49(1):38-41

CIRI, Centre International de Recherche en Infectiologie - International Center for Infectiology Research, Inserm, U1111, Ecole Normale Supérieure de Lyon, Université Lyon 1, CNRS, UMR5308, Lyon, France.

Eomesodermin (Eomes) is a transcription factor (TF) of the T-box family closely related to T-bet known for its role in CD8 T cell and natural killer cell differentiation. However, the role of Eomes in CD4 T-cell differentiation is less well appreciated. In this issue of the European Journal of Immunology [Eur. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/eji.20184800
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http://dx.doi.org/10.1002/eji.201848000DOI Listing
January 2019
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Self-glycerophospholipids activate murine phospholipid-reactive T cells and inhibit iNKT cell activation by competing with ligands for CD1d loading.

Eur J Immunol 2019 Feb 18;49(2):242-254. Epub 2018 Dec 18.

Autoimmunity and Tolerance Laboratory, Division of Rheumatology, Department of Medicine, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, USA.

Glycosphingolipids and glycerophospholipids bind CD1d. Glycosphingolipid-reactive invariant NKT-cells (iNKT) exhibit myriad immune effects, however, little is known about the functions of phospholipid-reactive T cells (PLT). We report that the normal mouse immune repertoire contains αβ T cells, which recognize self-glycerophospholipids such as phosphatidic acid (PA) in a CD1d-restricted manner and don't cross-react with iNKT-cell ligands. Read More

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http://doi.wiley.com/10.1002/eji.201847717
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http://dx.doi.org/10.1002/eji.201847717DOI Listing
February 2019
18 Reads

Already ENLIGHT-TENed? Equipping young immunologists with a combination of research-related and transferrable competencies.

Eur J Immunol 2018 Dec;48(12):1926-1928

Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany.

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http://doi.wiley.com/10.1002/eji.201870145
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http://dx.doi.org/10.1002/eji.201870145DOI Listing
December 2018
2 Reads

Impressum.

Authors:

Eur J Immunol 2018 Dec;48(12):2073

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http://dx.doi.org/10.1002/eji.201870146DOI Listing
December 2018
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B7H6 is a functional ligand for NKp30 in rat and cattle and determines NKp30 reactivity toward human cancer cell lines.

Eur J Immunol 2019 Jan 13;49(1):54-65. Epub 2018 Dec 13.

Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.

NK cells kill cancer cells and infected cells upon activation by cell surface receptors. Human NKp30 is an activating receptor expressed by all mature NK cells. The B7 family member B7H6 has been identified as one ligand for NKp30. Read More

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http://dx.doi.org/10.1002/eji.201847746DOI Listing
January 2019
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4.034 Impact Factor

B cells latently infected with murine gammaherpesvirus 68 (MHV-68) are present in the mouse thymus-A step toward immune evasion?

Eur J Immunol 2019 Feb 10;49(2):351-352. Epub 2018 Dec 10.

Research Unit Lung Repair and Regeneration, Helmholtz Zentrum München - German Research Center for Environmental Health (GmbH), Munich, Germany.

We show that latently gammaherpesvirus-infected B cells are present in the thymus. This could result in a functional T-cell tolerance against certain viral epitopes. It is conceivable that also antigens from other viruses or pathogens may be conveyed to the thymus for their immune evasion. Read More

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http://dx.doi.org/10.1002/eji.201847886DOI Listing
February 2019
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CD300 receptor family in viral infections.

Eur J Immunol 2018 Nov 28. Epub 2018 Nov 28.

Immunopathology Group, Biocruces Bizkaia Health Research Institute, Barakaldo, Bizkaia, Spain.

The CD300 molecules constitute an evolutionarily significant family of receptors that are expressed on myeloid and lymphoid cells, but also on other cell types, such as tuft cells. Many of the CD300 receptors have been shown to recognize lipids, e.g. Read More

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http://dx.doi.org/10.1002/eji.201847951DOI Listing
November 2018
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PD-1 expression is upregulated on adapted T cells in experimental autoimmune encephalomyelitis but is not required to maintain a hyporesponsive state.

Eur J Immunol 2019 Jan 7;49(1):112-120. Epub 2018 Dec 7.

MRC Centre for Inflammation Research, Centre for Multiple Sclerosis Research, Centre for Immunity, Infection and Evolution, The University of Edinburgh, Edinburgh, UK.

T cell adaptation is an important peripheral tolerogenic process which ensures that the T cell population can respond effectively to pathogens but remains tolerant to self-antigens. We probed the mechanisms of T cell adaptation using an experimental autoimmune encephalomyelitis (EAE) model in which the fate of autopathogenic T cells could be followed. We demonstrated that immunisation with a high dose of myelin basic protein (MBP) peptide and complete Freund's adjuvant failed to effectively initiate EAE, in contrast to low dose MBP peptide immunisation which readily induced disease. Read More

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http://dx.doi.org/10.1002/eji.201847868DOI Listing
January 2019
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