299,488 results match your criteria European Journal of Hospital Pharmacy Science EJHP-S[Journal]


Wildlife, human and environmental costs of using lead ammunition: An economic review and analysis.

Ambio 2019 Mar 16. Epub 2019 Mar 16.

Wildfowl & Wetlands Trust, Slimbridge, Gloucestershire, GL2 7BT, UK.

A proposed European Union (EU)-wide restriction on the use of lead gunshot for shooting in and over wetlands estimated that the societal benefits of a restriction outweighed costs, despite few identified benefits being quantified economically. A subsequent Annex XV Investigation Report on the evidence of impacts of lead ammunition in terrestrial environments concluded that additional measures to control its use are warranted, although to date this has not been further evaluated. To help inform this process, we review the literature and undertake new analyses to estimate the costs of continued use of lead ammunition associated with impacts on wildlife, people and the environment. Read More

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http://link.springer.com/10.1007/s13280-019-01157-2
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http://dx.doi.org/10.1007/s13280-019-01157-2DOI Listing
March 2019
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Switching "Real-World" Diabetes Patients to Degludec from Other Basal Insulins Provides Different Clinical Benefits According to Their Baseline Glycemic Control.

Adv Ther 2019 Mar 16. Epub 2019 Mar 16.

eSwiss Medical and Surgical Center, St Gallen, Switzerland.

Introduction: The stable, ultra-long duration of action of insulin degludec (degludec) minimizes fluctuations in glucose-lowering activity over the daily (24-h) dosing period, and comparative studies with other basal insulins suggest that these properties translate into a lower risk of hypoglycemia at equivalent levels of glycemic control. Results from the real-world European multicenter, retrospective chart review study of 2550 patients with type 1 and type 2 diabetes (T1D and T2D) in routine clinical care EU-TREAT (NCT02662114) showed that patients benefited from improved glycemic control and significantly reduced rates of hypoglycemia following a switch to degludec.

Methods: In this post hoc analysis, EU-TREAT patients were stratified into good (≤ 7. Read More

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http://dx.doi.org/10.1007/s12325-019-00916-7DOI Listing
March 2019
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Implementing an Updated "Break the Cycle" Intervention to Reduce Initiating Persons into Injecting Drug Use in an Eastern European and a US "opioid epidemic" Setting.

AIDS Behav 2019 Mar 16. Epub 2019 Mar 16.

HIV Center for Clinical and Behavioral Studies at The New York State Psychiatric Institute and Columbia University, New York, USA.

We tested the hypothesis that an updated "Break the Cycle" (BtC) intervention, based in social cognitive theory and motivational interviewing, would reduce the likelihood that current persons who inject drugs (PWID) would assist persons who do not inject drugs (non-PWID) with first injections in Tallinn, Estonia and Staten Island, New York City. 402 PWID were recruited, a baseline interview covering demographics, drug use, and assisting non-PWID with first drug injections was administered, followed by BtC intervention. 296 follow-up interviews were conducted 6 months post-intervention. Read More

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http://dx.doi.org/10.1007/s10461-019-02467-yDOI Listing

A novel method to address the association between received dose intensity and survival outcome: benefits of approaching treatment intensification at a more individualised level in a trial of the European Osteosarcoma Intergroup.

Cancer Chemother Pharmacol 2019 Mar 16. Epub 2019 Mar 16.

Mathematical Institute Leiden University, Niels Bohrweg 1, 2333 CA, Leiden, The Netherlands.

Purpose: There is lack of consensus on the prognostic value of received high dose intensity in osteosarcoma survivorship. Many studies have not shown a clear survival benefit when dose intensity is increased. The aim of this study is to go beyond chemotherapy intensification by arm-wide escalation of intended dose and/or compression of treatment schedule, while conversely addressing the relationship between treatment intensity and survival at the patient level. Read More

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http://dx.doi.org/10.1007/s00280-019-03797-3DOI Listing

European consensus-based recommendations for diagnosis and treatment of immunoglobulin A vasculitis-the SHARE initiative.

Rheumatology (Oxford) 2019 Mar 16. Epub 2019 Mar 16.

Department of Paediatric Rheumatology, Alder Hey Children's NHS Foundation Trust, Liverpool, UK.

Objectives: IgA vasculitis (IgAV, formerly known as Henoch-Schönlein purpura) is the most common cause of systemic vasculitis in childhood. To date, there are no internationally agreed, evidence-based guidelines concerning the appropriate diagnosis and treatment of IgAV in children. Accordingly, treatment regimens differ widely. Read More

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http://dx.doi.org/10.1093/rheumatology/kez041DOI Listing

Pros and cons of antithrombotic therapy in end-stage kidney disease: a 2019 update.

Nephrol Dial Transplant 2019 Mar 16. Epub 2019 Mar 16.

the Academy of Romanian Scientists (AOSR).

Dialysis patients manifest both an increased thrombotic risk and a haemorrhagic tendency. A great number of patients with chronic kidney disease requiring dialysis have cardiovascular comorbidities (coronary artery disease, atrial fibrillation or venous thromboembolism) and different indications for treatment with antithrombotics (primary or secondary prevention). Unfortunately, few randomized controlled trials deal with antiplatelet and/or anticoagulant therapy in dialysis. Read More

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http://dx.doi.org/10.1093/ndt/gfz040DOI Listing

A European study on decellularized homografts for pulmonary valve replacement: initial results from the prospective ESPOIR Trial and ESPOIR Registry data†.

Eur J Cardiothorac Surg 2019 Mar 15. Epub 2019 Mar 15.

Department of Cardiac, Thoracic, Transplantation, and Vascular Surgery, Hannover Medical School, Hannover, Germany.

Objectives: Decellularized pulmonary homografts (DPH) have shown excellent results for pulmonary valve replacement. However, controlled multicentre studies are lacking to date.

Methods: Prospective European multicentre trial evaluating DPH for pulmonary valve replacement. Read More

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http://dx.doi.org/10.1093/ejcts/ezz054DOI Listing

Utilisation of mammography by women with mobility impairment in the UK: secondary analysis of cross-sectional data.

BMJ Open 2019 Mar 15;9(3):e024571. Epub 2019 Mar 15.

Centre of Environmental and Natural Resource Economics, Faculty of Economics and Business, Universidad de Chile, Santiago de Chile, Chile.

Objectives: Research has shown that people with physical impairment report lower utilisation of preventive services. The aim of this study was to examine whether women with mobility impairments have lower odds of using mammography compared with women with no such impairment, and explore the factors that are associated with lower utilisation.

Sample And Design: We performed secondary analysis, using logistic regressions, of deidentified cross-sectional data from the European Health Interview Survey, Wave 2. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-024571DOI Listing

Orchiectomy in species: technical aspects and effect on courtship behaviour.

Vet Rec 2019 Mar 16. Epub 2019 Mar 16.

Clinic for Zoo Animals, Exotic Pets and Wildlife, University of Zurich, Zurich, Switzerland.

Courtship behaviour of tortoises includes biting, ramming, chasing, same-sex sexual behaviour, and it commonly is excessive in European tortoise species kept as pets. As a result, males are kept individually. To assess the effect of orchiectomy on excessive courtship behaviour in European tortoises, 50 tortoises ( , and ) underwent endoscopically assisted orchiectomy from April through September 2013 to 2017. Read More

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http://dx.doi.org/10.1136/vr.105095DOI Listing

Muscle fibre morphology and microarchitecture in cerebral palsy patients obtained by 3D synchrotron X-ray computed tomography.

Comput Biol Med 2019 Feb 14;107:265-269. Epub 2019 Feb 14.

Department of Neuroscience, University of Copenhagen, Denmark.

Background: Synchrotron X-ray computed tomography (SXCT) allows for three-dimensional imaging of objects at a very high resolution and in large field-of-view.

Purpose: The aim of this study was to use SXCT imaging for morphological analysis of muscle tissue, in order to investigate whether the analysis reveals complementary information to two-dimensional microscopy.

Methods: Three-dimensional SXCT images of muscle biopsies were taken from participants with cerebral palsy and from healthy controls. Read More

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http://dx.doi.org/10.1016/j.compbiomed.2019.02.008DOI Listing
February 2019

Determination of homogeneity of the top surface deadlayer in an old HPGe detector.

Appl Radiat Isot 2019 Mar 4;147:182-188. Epub 2019 Mar 4.

SCK, CEN, Boeretang, 2400, Mol, Belgium.

A collimated source of Am was scanned over the endcap of a 21 year old coaxial HPGe-detector that had spent about 75% of its life at room temperature (and the remaining time at 77 K). The detector response was recorded and used as a measure of the relative thickness of the top deadlayer. This thickness was not homogeneous and was thicker near to the outer surface of the crystal compared to the centre, which could be a result of increased diffusion of Li atoms during times the detector was kept at room temperature. Read More

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http://dx.doi.org/10.1016/j.apradiso.2019.02.019DOI Listing

Progress in neuromodulation of the brain; a role for magnetic nanoparticles?

Prog Neurobiol 2019 Mar 13. Epub 2019 Mar 13.

School for Mental Health and Neuroscience, Departments of Neurosurgery, Maastricht University, Maastricht, 6200 MD, The Netherlands; European Graduate School of Neuroscience (EURON); Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Department of Neurosurgery, Nijmegen, The Netherlands. Electronic address:

The field of neuromodulation is developing rapidly. Current techniques, however, are still limited as they i) either depend on permanent implants, ii) require invasive procedures, iii) are not cell-type specific, iv) involve slow pharmacokinetics or v) have a restricted penetration depth making it difficult to stimulate regions deep within the brain. Refinements into the different fields of neuromodulation are thus needed. Read More

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http://dx.doi.org/10.1016/j.pneurobio.2019.03.002DOI Listing

A view of the maternal inheritance of Espírito Santo populations: The contrast between the admixed and Pomeranian descent groups.

Forensic Sci Int Genet 2019 Mar 6;40:175-181. Epub 2019 Mar 6.

Núcleo de Genética Humana e Molecular (NGHM), Universidade Federal do Espírito Santo (UFES), Fernando Ferrari Avenue, 514 - Goiabeiras, Vitória, Espírito Santo, 29075-910, Brazil; Programa de Pós-Graduacão em Biotecnologia, Universidade Federal do Espírito Santo (UFES), Marechal Campos Avenue, 1468 - Bonfim, Vitória, Espírito Santo, 29047-105, Brazil.

In addition to its valuable utility in forensic investigations, mitochondrial DNA (mtDNA) analysis is a reliable tool to uncover the origins of admixed populations, such as Brazilians. The state of Espírito Santo (ES), similar to other coastal Brazilian states, has a population shaped by 3 main ancestral roots: Amerindian, African and European. Among the latter, the Pomeranian descendants stand out due to the preservation of the traditional aspects of their culture, especially the Pomeranian language. Read More

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http://dx.doi.org/10.1016/j.fsigen.2019.03.007DOI Listing

Choice of protocol for the in vivo bioassay of equine Chorionic Gonadotropin (eCG / PMSG) in immature female rats.

Theriogenology 2019 Mar 9;130:99-102. Epub 2019 Mar 9.

CNRS, INRA, Physiologie de la Reproduction et des Comportements (PRC), 37380, Nouzilly, France.

Equine Chorionic Gonadotropin (eCG) previously known as Pregnant Mare Serum Gonadotropin (PMSG) has been used for decades in regulating reproduction in various domestic animal species. Its use necessitates a good measurement of its bioactivity in commercial preparations. The EUROPEAN PHARMACOPEIA (EP 7. Read More

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http://dx.doi.org/10.1016/j.theriogenology.2019.03.004DOI Listing

Dynamics on clonal and plasmid backgrounds of Enterobacteriaceae producing acquired AmpC in Portuguese clinical settings throughout time.

Int J Antimicrob Agents 2019 Mar 13. Epub 2019 Mar 13.

UCIBIO/REQUIMTE. Laboratório de Microbiologia, Faculdade de Farmácia, Universidade do Porto, Porto, Portugal. Electronic address:

Objectives: To provide detailed molecular data on clinical acquired AmpC (qAmpC)-producing Enterobacteriaceae from two different periods (2002-2008 and 2010-2013) in order to clarify the contribution of clonal and plasmid genetic platforms for the current epidemiological scenario concerning extended-spectrum beta-lactams resistance.

Methods: We analysed 1246 Enterobacteriaceae non-susceptible to third-generation cephalosporins from 2 hospitals and 1 community laboratory between 2010 and 2013. Bacterial identification, antibiotic susceptibility, identification of qAmpC and plasmid-mediated quinolone resistance genes, clonal (PFGE, MLST) and plasmid (S1-/I-CeuI-PFGE, replicon typing, hybridization) analysis were performed by standard methods. Read More

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http://dx.doi.org/10.1016/j.ijantimicag.2019.03.013DOI Listing

Unique device identification and traceability for medical software: A major challenge for manufacturers in an ever-evolving marketplace.

J Biomed Inform 2019 Mar 13:103150. Epub 2019 Mar 13.

Institute of Clinical Physiology, CNR, Pisa, Italy.

Background And Objectives: Similarly to what already established and implemented in the United States, the concept of the Unique Device Identification (UDI) system has been introduced with the European Regulations for medical devices MDR (EU) 2017/745 and in-vitro diagnostic medical devices IVDR (EU) 2017/746 and it is on the way to become a worldwide standard. The aim of this work was to provide a possible approach for the implementation of UDI and traceability in Europe for standalone software medical devices according to lifecycle and quality system standards.

Methods: The key points of the UDI regulation were determined and analyzed in order to identify the main issues related to the manufacturing of software medical devices and, in particular, labeling, privacy aspects, UDI assignment criteria, and international standards compliance. Read More

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http://dx.doi.org/10.1016/j.jbi.2019.103150DOI Listing

Ccne1 Overexpression Causes Chromosome Instability in Liver Cells and Liver Tumor Development in Mice.

Gastroenterology 2019 Mar 13. Epub 2019 Mar 13.

Department of Biochemistry and Molecular Biology; Department of Pediatric and Adolescent Medicine; Department of Pediatrics. Electronic address:

Background & Aims: The CCNE1 locus, which encodes cyclin E1, is amplified in many types of cancer cells and is activated in hepatocellular carcinomas (HCCs) from patients infected with hepatitis B virus or adeno-associated virus type 2, due to integration of the virus nearby. We investigated cell cycle and oncogenic effects of cyclin E1 overexpression in tissues of mice.

Methods: We generated mice with doxycycline-inducible expression of Ccne1 (Ccne1 mice) and activated overexpression of cyclin E1 from age 3 weeks onwards. Read More

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http://dx.doi.org/10.1053/j.gastro.2019.03.016DOI Listing

Epidemiology and burden of pancreatic cancer.

Presse Med 2019 Mar 13. Epub 2019 Mar 13.

Unit of Clinical Epidemiology, IEO, European Institute of Oncology IRCCS, Milan, Italy. Electronic address:

Pancreatic cancer, although infrequent, has a very poor prognosis, making it currently the fourth common causes of cancer mortality in most developed countries including the European Union (EU). Its incidence varies across regions, which suggests that lifestyle factors play an important role in its etiology, although part of the variation could be ascribed to difference in diagnostic and coding practices. Because pancreatic cancer is strongly age-dependent, increasing population longevity and ageing will lead to an increase of the global burden of pancreatic cancer. Read More

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http://dx.doi.org/10.1016/j.lpm.2019.02.030DOI Listing

Recommendations of the Spanish Antibiogram Committee (COESANT) for selecting antimicrobial agents and concentrations for in vitro susceptibility studies using automated systems.

Enferm Infecc Microbiol Clin 2019 Mar 13. Epub 2019 Mar 13.

Red Española de Investigación en Patología Infecciosa (REIPI), Instituto de Salud Carlos III, Madrid, Spain; Unidad de Gestión Clínica de Microbiología, Hospital Reina Sofía, Departamento de Microbiología, Universidad de Córdoba, Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain.

Automated antimicrobial susceptibility testing devices are widely implemented in clinical microbiology laboratories in Spain, mainly using EUCAST (European Committee on Antimicrobial Susceptibility Testing) breakpoints. In 2007, a group of experts published recommendations for including antimicrobial agents and selecting concentrations in these systems. Under the patronage of the Spanish Antibiogram Committee (Comité Español del Antibiograma, COESANT) and the Study Group on Mechanisms of Action and Resistance to Antimicrobial Agents (GEMARA) from the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC), and aligned with the Spanish National Plan against Antimicrobial Resistance (PRAN), a group of experts have updated this document. Read More

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http://dx.doi.org/10.1016/j.eimc.2019.01.017DOI Listing

Inequality among industrial workers in the late 19th century United States.

Authors:
Michael R Haines

Econ Hum Biol 2019 Mar 4. Epub 2019 Mar 4.

Department of Economics, Colgate University, 13 Oak Drive, Hamilton, NY 13346, United States. Electronic address:

This paper uses the large cross sectional survey of 8544 workers in nine industries (pig iron, bar iron, steel, coal, coke, cottons, woolens, and glass) in the United States and five European countries (Belgium, Great Britain, France, Belgium, and Switzerland) to examine inequality in the industrial working class in the late nineteenth century. The paper looks at incomes, the food budget share (estimated using the Almost Ideal Demand System), and home ownership. The results show regular gradients with the unskilled workers doing less well than semi-skilled and skilled workers. Read More

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http://dx.doi.org/10.1016/j.ehb.2019.02.005DOI Listing

Training in communication skills, end-of-life care, and coping strategies as the key to preventing burnout in clinicians.

Aust Crit Care 2019 Mar 13. Epub 2019 Mar 13.

Department of Biological and Health Psychology, Universidad Autónoma de Madrid, Spain.

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http://dx.doi.org/10.1016/j.aucc.2019.01.008DOI Listing

Barriers to health care access and service utilization of refugees in Austria: Evidence from a cross-sectional survey.

Health Policy 2019 Mar 6. Epub 2019 Mar 6.

Johannes Kepler University Linz, and Vienna Institute for International Economic Studies (wiiw), Rahlgasse 5, 1060 Vienna, Austria. Electronic address:

This paper provides evidence on (1) refugees' subjective well-being, (2) their access and barriers to health care utilization and (3) their perception of health care provision in Austria, one of the countries most heavily affected by the European 'refugee crisis.' It is based on primary data from the Refugee Health and Integration Survey (ReHIS), a cross-sectional survey of roughly five hundred Syrian, Iraqi and Afghan refugees. Results indicate that refugees' self-rated health falls below the resident population's, in particular for female and Afghan refugees. Read More

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http://dx.doi.org/10.1016/j.healthpol.2019.01.014DOI Listing

Improving lives by accelerating progress towards the UN Sustainable Development Goals for adolescents living with HIV: a prospective cohort study.

Lancet Child Adolesc Health 2019 Apr;3(4):245-254

Department of Global Health, University College London, London, UK.

Background: Low-income and middle-income countries (LMICs) face major challenges in achieving the UN's Sustainable Development Goals (SDGs) for vulnerable adolescents. We aimed to test the UN Development Programme's proposed approach of development accelerators-provisions that lead to progress across multiple SDGs-and synergies between accelerators on achieving SDG-aligned targets in a highly vulnerable group of adolescents in South Africa.

Methods: We did standardised interviews and extracted longitudinal data from clinical records at baseline (2014-15) and 18-month follow-up (2016-17) for adolescents aged 10-19 years living with HIV in the Eastern Cape province of South Africa. Read More

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http://dx.doi.org/10.1016/S2352-4642(19)30033-1DOI Listing

Bisphenol P activates hormonal genes and introduces developmental outcomes in Chironomus tentans.

Ecotoxicol Environ Saf 2019 Mar 13;174:675-682. Epub 2019 Mar 13.

College of Life Sciences, Nanjing Normal University, 1 Wenyuan Road, Nanjing 210023, China. Electronic address:

The endocrine disrupting properties of bisphenol A (BPA) discharged to the environment have been newly identified by the European Chemicals Agency, increasing the need to assess the environmental endocrine disrupting potentials of its alternatives with which it shares close structural features. However, few investigations of the environmental endocrine disrupting functions of BPA analogs have been conducted to date. In this study, the endocrine disrupting effects of a BPA analog of bisphenol P (BPP) were investigated in the nonbiting midge (Chironomus tentans), a model organism in ecotoxicology. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2019.03.018DOI Listing

A simple dilute-and-shoot method for screening and simultaneous quantification of nicotine and alkaloid impurities in electronic cigarette refills (e-liquids) by UHPLC-DAD.

J Pharm Biomed Anal 2019 Mar 2;169:225-234. Epub 2019 Mar 2.

Medicines and health products, Scientific Direction of Chemical and Physical Health Risks, Sciensano, Rue Juliette Wytsmanstraat 14, 1050 Brussels, Belgium. Electronic address:

The electronic cigarette (e-cigarette) has emerged as a popular alternative to the traditional hazardous tobacco cigarette. The substantial increase in e-cigarette use also urgently calls for controlling the quality of e-cigarette refill liquid products (e-liquids). Currently, the most important quality indicator of e-liquid products is the quantification of nicotine and its related impurities. Read More

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http://dx.doi.org/10.1016/j.jpba.2019.03.002DOI Listing

Soft tissue grafts for dural reconstruction after meningioma surgery.

Bosn J Basic Med Sci 2019 Mar 11. Epub 2019 Mar 11.

Department of Neurosurgery, University Medical Centre Ljubljana, Ljubljana, Slovenia; Alma Mater Europaea - European Center Maribor (AMEU-ECM), Maribor, Slovenia.

The meninges are involved in various pathologies and are often directly or indirectly severed during surgical procedures, especially the dura mater. This can pose a real challenge for the surgeon, as a proper reconstruction of the meninges is important to prevent complications such as cerebrospinal fluid leak (CSF). A variety of techniques for dural reconstruction have been described, employing natural and artificial materials. Read More

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http://dx.doi.org/10.17305/bjbms.2019.3949DOI Listing

Selection for temperament has no negative consequences on important production traits in farmed mink.

J Anim Sci 2019 Mar 16. Epub 2019 Mar 16.

Department of Molecular Biology and Genetics, Aarhus University, Tjele, Denmark.

Danish and European legislation recommends mink breeding programs that include selection for "confidence", defined as exploratory activity in a standardized behavioral test. Although this recommendation may improve mink welfare, farmers may consider this criterion risky due to possible negative consequences on other traits. The overall objectives of this study were to estimate the heritability of exploratory/fearful behavior, and to identify genetic correlations with other traits of major economic importance in mink fur production. Read More

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http://dx.doi.org/10.1093/jas/skz089DOI Listing
March 2019
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Close-Person Spill-Overs in End-of-Life Care: Using Hierarchical Mapping to Identify Whose Outcomes to Include in Economic Evaluations.

Pharmacoeconomics 2019 Mar 15. Epub 2019 Mar 15.

School of Social and Community Medicine, University of Bristol, Bristol, UK.

Background: Guidelines for economic evaluations often request that costs and outcomes beyond the patient are captured; this can include carers and also other affected parties. End-of-life care is one context where impacts of care spill over onto those other than patients, but there is little evidence about who should be included within economic evaluations.

Objective: The purpose of this article was to examine (1) how many people are close to those at the end of life (2); their characteristics; and (3) what influences the network size at the end of life. Read More

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http://dx.doi.org/10.1007/s40273-019-00786-5DOI Listing

Aflatoxin production and in vitro toxicity of Aspergilli section Flavi isolated from air samples collected from different environments.

Mycotoxin Res 2019 Mar 12. Epub 2019 Mar 12.

Department of Microbiology, Faculty of Pharmacy and Biochemistry, University of Zagreb, Schrottova 39, 10000, Zagreb, Croatia.

Aspergilli section Flavi, originally isolated from air samples collected from inhabited apartments (AP), unoccupied basements (BS), and processing facilities of a grain mill (GM), were analyzed for their potential to produce aflatoxin B (AFB) on solid media. The isolates were further characterized with regard to their cytotoxic, genotoxic, and pro-inflammatory properties in vitro. Aspergilli were identified based on partial calmodulin (CaM) gene sequencing; the producing capacities of isolates were analyzed by HPLC/FLD and confirmed by genes in biosynthesis (aflR, norA, omtA). Read More

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http://dx.doi.org/10.1007/s12550-019-00345-zDOI Listing

Summary of the proceedings of the International Forum 2018: "Value-based radiology".

Authors:

Insights Imaging 2019 Mar 15;10(1):34. Epub 2019 Mar 15.

The International Forum, established by the European Society of Radiology (ESR), aims to discuss important topics in the field of radiology with radiological partner societies from outside Europe. Value-based healthcare is currently a hot topic around the world and has been addressed in many papers. The ESR chose the topic "value-based radiology" for the ESR International Forum at ECR 2018 to discuss the trend within radiology to move from volume-based to value-based practice. Read More

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http://dx.doi.org/10.1186/s13244-019-0717-7DOI Listing

Comparative reproductive dormancy differentiation in European black scavenger flies (Diptera: Sepsidae).

Oecologia 2019 Mar 14. Epub 2019 Mar 14.

Department of Evolutionary Biology and Environmental Studies, University of Zurich, Winterthurerstrasse 190, 8057, Zurich, Switzerland.

Seasonality is a key environmental factor that regularly promotes life history adaptation. Insects invading cold-temperate climates need to overwinter in a dormant state. We compared the role of temperature and photoperiod in dormancy induction in the laboratory, as well as winter survival and reproduction in the field and the laboratory, of 5 widespread European dung fly species (Diptera: Sepsidae) to investigate their extent of ecological differentiation and thermal adaptation. Read More

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http://dx.doi.org/10.1007/s00442-019-04378-0DOI Listing

Laparoscopic subtotal colectomy with double-end ileosigmoidostomy in right iliac fossa facilitates second-stage surgery in patients with inflammatory bowel disease.

Surg Endosc 2019 Mar 14. Epub 2019 Mar 14.

Department of Colorectal Surgery, Beaujon Hospital, Assistance Publique-Hôpitaux de Paris, Université Paris VII, 100 Boulevard du Général Leclerc, 92110, Clichy, France.

Background: There is no consensus about the most appropriate management of rectal stump in laparoscopic subtotal colectomy (STC) performed for inflammatory bowel disease (IBD). The objective is to report our experience of laparoscopic STC with double-end ileosigmoidostomy in the right iliac fossa for IBD.

Methods: All patients undergoing laparoscopic STC and double-end ileosigmoidostomy in the right iliac fossa for IBD in 2 European expert centres were included. Read More

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http://dx.doi.org/10.1007/s00464-019-06749-3DOI Listing
March 2019
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Identification of naphthalene carboxylase subunits of the sulfate-reducing culture N47.

Biodegradation 2019 Mar 15. Epub 2019 Mar 15.

Biofilm Centre, Universität Duisburg-Essen, Essen, Germany.

Expanding industrialization and the associated usage and production of mineral oil products has caused a worldwide spread of polycyclic aromatic hydrocarbons. These pollutants accumulate and persist under anoxic conditions but little is known about the biochemical reactions catalyzing their anaerobic degradation. Recently, carboxylation of naphthalene was demonstrated for the sulfate-reducing culture N47. Read More

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http://dx.doi.org/10.1007/s10532-019-09872-zDOI Listing

Prevalence of fosfomycin resistance among ESBL-producing Escherichia coli isolates in the community, Switzerland.

Eur J Clin Microbiol Infect Dis 2019 Mar 15. Epub 2019 Mar 15.

Emerging Antibiotic Resistance Unit, Medical and Molecular Microbiology, Faculty of Science and Medicine, University of Fribourg, Chemin du Musée 18, 1700, Fribourg, Switzerland.

Our aim was to evaluate the prevalence of fosfomycin-resistant strains among ESBL-producing Escherichia coli isolates recovered from community patients in Switzerland. A total of 1225 ESBL-producing E. coli isolates were collected between 2012 and 2013 from a private and community laboratory. Read More

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http://dx.doi.org/10.1007/s10096-019-03531-0DOI Listing

Univariate comparison of performance of different cerebrovascular reactivity indices for outcome association in adult TBI: a CENTER-TBI study.

Acta Neurochir (Wien) 2019 Mar 15. Epub 2019 Mar 15.

Brain Physics Laboratory, Division of Neurosurgery, Dept of Clinical Neurosciences, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK.

Background: Monitoring cerebrovascular reactivity in adult traumatic brain injury (TBI) has been linked to global patient outcome. Three intra-cranial pressure (ICP)-derived indices have been described. It is unknown which index is superior for outcome association in TBI outside previous single-center evaluations. Read More

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http://dx.doi.org/10.1007/s00701-019-03844-1DOI Listing

Evidence of Neospora caninum infection in buffaloes (Bubalus bubalis) from Northwestern Romania.

Parasitol Res 2019 Mar 15. Epub 2019 Mar 15.

Department of Parasitology and Parasitic Diseases, Faculty of Veterinary Medicine, University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, Calea Mănăștur nr. 3-5, 400372, Cluj-Napoca, Romania.

Neospora caninum is a heteroxenous parasitic Apicomplexan protozoan, able to infect a variety of domestic and wild animals, mainly associated with reproductive disorders and abortions in susceptible species. Considering the importance of Romania in the European buffalo industry and the severe economic losses caused by N. caninum infection in livestock, the aim of the present study was to assess the occurrence of neosporosis in buffaloes raised in household and farming systems in northwestern Romania. Read More

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http://dx.doi.org/10.1007/s00436-019-06263-4DOI Listing

Methylobacterium oryzae CBMB20 influences photosynthetic traits, volatile emission and ethylene metabolism in Oryza sativa genotypes grown in salt stress conditions.

Planta 2019 Mar 15. Epub 2019 Mar 15.

Institute of Agricultural and Environmental Sciences, Estonian University of Life Sciences, Kreutzwaldi 1, 51006, Tartu, Estonia.

Main Conclusion: Inoculation of endophytic Methylobacterium oryzae CBMB20 in salt-stressed rice plants improves photosynthesis and reduces stress volatile emissions due to mellowing of ethylene-dependent responses and activating vacuolar H-ATPase. The objective of this study was to analyze the impact of ACC (1-aminocyclopropane-1-carboxylate) deaminase-producing Methylobacterium oryzae CBMB20 in acclimation of plant to salt stress by controlling photosynthetic characteristics and volatile emission in salt-sensitive (IR29) and moderately salt-resistant (FL478) rice (Oryza sativa L.) cultivars. Read More

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http://dx.doi.org/10.1007/s00425-019-03139-wDOI Listing

Invited review-next-generation sequencing: a modern tool in cytopathology.

Virchows Arch 2019 Mar 15. Epub 2019 Mar 15.

Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal.

In recent years, cytopathology has established itself as an independent diagnostic modality to guide clinical management in many different settings. The application of molecular techniques to cytological samples to identify prognostic and predictive biomarkers has played a crucial role in achieving this goal. While earlier studies have demonstrated that single biomarker testing is feasible on cytological samples, currently, this provides only limited and increasingly insufficient information in an era where an increasing number of biomarkers are required to guide patient care. Read More

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http://dx.doi.org/10.1007/s00428-019-02559-zDOI Listing

Unmet needs in the treatment of ankylosing spondylitis: a long-term observational study from a single university center.

Rheumatol Int 2019 Mar 15. Epub 2019 Mar 15.

Rheumatology Clinic, Department of Internal Medicine, Medical School, University of Ioannina, Ioannina, Greece.

Despite the progress in the treatment of ankylosing spondylitis (AS), a significant number of patients do not achieve low disease activity (LDA). The aim of the study is to estimate the size of unmet needs in the treatment of AS in a long-term observational study. Between January 2003 and December 2017, 220 patients with radiographic SpA were evaluated fulfilling the ASAS criteria. Read More

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http://dx.doi.org/10.1007/s00296-019-04277-wDOI Listing

Impact of health technology assessment and managed entry schemes on reimbursement decisions of centrally authorised medicinal products in Belgium.

Eur J Clin Pharmacol 2019 Mar 15. Epub 2019 Mar 15.

Department of clinical pharmacology and pharmacotherapy, Vrije Universiteit Brussel, Brussels, Belgium.

Purpose: Centrally authorised medicinal products (CAMPs) in the European Union may offer added therapeutic value (ATV) but may be linked to high prices and limited efficiency. Health technology assessment (HTA) and managed entry schemes (MES) may facilitate the reimbursement decision by providing reliable estimates of the medicinal product's value and costs and by controlling the remaining uncertainty, respectively. We investigated the impact of HTA criteria and the initiation of a MES on the reimbursement decision of CAMPs in Belgium. Read More

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http://dx.doi.org/10.1007/s00228-019-02665-6DOI Listing

Testcross performance of doubled haploid lines from European flint maize landraces is promising for broadening the genetic base of elite germplasm.

Theor Appl Genet 2019 Mar 15. Epub 2019 Mar 15.

Institute of Plant Breeding, Seed Sciences and Population Genetics, University of Hohenheim, Fruwirthstraße 21, 70599, Stuttgart, Germany.

Key Message: Selected doubled haploid lines averaged similar testcross performance as their original landraces, and the best of them approached the yields of elite inbreds, demonstrating their potential to broaden the narrow genetic diversity of the flint germplasm pool. Maize landraces represent a rich source of genetic diversity that remains largely idle because the high genetic load and performance gap to elite germplasm hamper their use in modern breeding programs. Production of doubled haploid (DH) lines can mitigate problems associated with the use of landraces in pre-breeding. Read More

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http://dx.doi.org/10.1007/s00122-019-03325-0DOI Listing

Reviewer recognition.

Authors:

Eur J Hum Genet 2019 Mar 15. Epub 2019 Mar 15.

In this issue we would like to thank all those listed below for taking the time to review for the European Journal of Human Genetics in 2018-your generosity is much appreciated and we hope your association with the journal continues in the future. Read More

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http://dx.doi.org/10.1038/s41431-019-0367-8DOI Listing

Plant glutathione biosynthesis revisited: Redox-mediated activation of glutamylcysteine ligase does not require homo-dimerization.

Biochem J 2019 Mar 15. Epub 2019 Mar 15.

COS Heidelberg, Heidelberg University, INF 360, Heidelberg, 69120, Germany

Plant ɣ-glutamylcysteine ligase (GCL), catalyzing the first and tightly regulated step of glutathione biosynthesis, is redox-activated via formation of an intramolecular disulfide bond. , redox-activation of recombinant GCL protein causes formation of homo-dimers. Here we have investigated whether dimerization occurs and if so whether it contributes to redox-activation. Read More

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http://dx.doi.org/10.1042/BCJ20190072DOI Listing

Recombinant nodavirus vaccine produced in bacteria and administered without purification elicits humoral immunity and protects European sea bass against infection.

Fish Shellfish Immunol 2019 Mar 12. Epub 2019 Mar 12.

Fish Innate Immune System Group, Department of Cell Biology and Histology, Faculty of Biology, Campus Regional de Excelencia Internacional "Campus Mare Nostrum", University of Murcia, 30100, Murcia, Spain. Electronic address:

Viral necrosis virus (NNV) or nodavirus causes fish viral encephalopathy and retinopathy worldwide. In some cases, mortalities in aquaculture industry can reach up to 100%, some species being especially sensitive as is the case of European sea bass (Dicentrarchus labrax), one of the main cultured species in the Mediterranean, with the consequent economical loses. Development of new vaccines against NNV is in the spotlight though few researches have focused in European sea bass. Read More

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http://dx.doi.org/10.1016/j.fsi.2019.03.013DOI Listing

Nutrition, Obesity and Cachexia in Patients with Heart Failure: A Consensus Statement from the HFSA Scientific Statements Committee.

J Card Fail 2019 Mar 12. Epub 2019 Mar 12.

Cardiovascular Division, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.

Dietary guidance for patients with heart failure (HF) has traditionally focused on sodium and fluid intake restriction, but dietary quality is frequently poor in patients with HF and may contribute to morbidity and mortality. Restrictive dietary counselling can lead to inadequate intake of macronutrients and micronutrients by patients with HF, with the potential for deficiencies of calcium, magnesium, zinc, iron, thiamine, vitamins D, E, K, and folate. Although inadequate intake and low plasma levels of micronutrients have been associated with adverse clinical outcomes, evidence supporting therapeutic repletion is limited. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10719164183091
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http://dx.doi.org/10.1016/j.cardfail.2019.03.007DOI Listing
March 2019
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Development of a dosing device for individualized dosing of orodispersible warfarin films.

Int J Pharm 2019 Mar 13;561:314-323. Epub 2019 Mar 13.

Heinrich Heine University Düsseldorf, Institute of Pharmaceutics and Biopharmaceutics, Universitätsstr. 1, 40225 Düsseldorf, Germany. Electronic address:

Individualized medicine is relevant to ensure safe and efficient pharmacotherapy. It requires a suitable dosage form and a matching dosing device to enable flexible dosing serving the needs of individual dose requirements. For oral films no flexible dosing option is available until today. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2019.03.019DOI Listing

Genomic Basis of Delayed Reward Discounting.

Behav Processes 2019 Mar 12. Epub 2019 Mar 12.

Department of Psychiatry, University of California San Diego, 9500 Gilman Dr., La Jolla, CA 92093, USA; Institute for Genomic Medicine, University of California San Diego, 9500 Gilman Dr., La Jolla, CA 92093, USA. Electronic address:

Delayed reward discounting (DRD) is a behavioral economic measure of impulsivity, reflecting how rapidly a reward loses value based on its temporal distance. In humans, more impulsive DRD is associated with susceptibility to a number of psychiatric diseases (e.g. Read More

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http://dx.doi.org/10.1016/j.beproc.2019.03.006DOI Listing

A case of autosomal recessive hypercholesterolemia caused by a new variant in the LDL receptor adaptor protein 1 gene.

J Clin Lipidol 2019 Feb 16. Epub 2019 Feb 16.

Centre for Cardiovascular Surgery and Transplantation, Brno, Czech Republic; Central European Institute of Technology and Medical Faculty, Masaryk University, Brno, Czech Republic.

We report a new variant in the LDLRAP1 gene associated with autosomal recessive hypercholesterolemia in a woman of central European ancestry. Read More

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http://dx.doi.org/10.1016/j.jacl.2019.02.003DOI Listing
February 2019

Supercritical fluid chromatography coupled to tandem mass spectrometry for the analysis of pesticide residues in dried spices. Benefits and drawbacks.

Anal Chim Acta 2019 Jun 18;1059:124-135. Epub 2019 Jan 18.

European Union Reference Laboratory for Pesticide Residues in Fruits & Vegetables, University of Almeria, Agrifood Campus of International Excellence (ceiA3) Department of Hydrogeology and Analytical Chemistry, Ctra. Sacramento S/N°, La Cañada de San Urbano, 04120, Almería, Spain. Electronic address:

This study describes the high sensitivity and the reduced ion suppression and matrix effect that can be achieved by supercritical fluid chromatography (SFC) in the analysis of dried spices as complex matrices. Samples selected for the evaluation were cayenne and black pepper, which are representative of complex dried spices. To carry out the evaluation of this technique, blank samples were fortified with a solution containing 162 pesticides at two concentration levels (50 and 200 μg kg). Read More

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http://dx.doi.org/10.1016/j.aca.2019.01.010DOI Listing

Molecularly imprinted polymers coupled to mass spectrometric detection for metallothionein sensing.

Talanta 2019 Jun 25;198:224-229. Epub 2019 Jan 25.

Department of Chemistry and Biochemistry, Mendel University in Brno, Zemedelska 1, CZ-613 00 Brno, Czech Republic; Central European Institute of Technology, Brno University of Technology, Purkynova 123, CZ-612 00 Brno, Czech Republic. Electronic address:

We report a facile method for detection of metallothionein (MT), a promising clinically relevant biomarker, in spiked plasma samples. This method, for the first time, integrates molecularly imprinted polymers as purification/pretreatment step with matrix assisted laser desorption/ionization time-of-flight mass spectrometric detection and with laser ablation inductively coupled plasma mass spectrometry for analysis of MTs. The prepared MT-imprinted polydopamine layer showed high binding capacity and specific recognition properties toward the template. Read More

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http://dx.doi.org/10.1016/j.talanta.2019.01.089DOI Listing