302,032 results match your criteria European Journal of Hospital Pharmacy Practice EJHP-P[Journal]


Evaluating the Effect of Monitoring through Telephone (Tele-Monitoring) on Self-Care Behaviors and Readmission of Patients with Heart Failure after Discharge.

Appl Clin Inform 2019 Mar 17;10(2):261-268. Epub 2019 Apr 17.

Department of Nursing & Emergency Medicine, Dezful University of Medical Sciences, Dezful, Iran.

Background:  Heart failure is one of the serious cardiovascular diseases, which poses a global pandemic and places a heavy burden on health care systems worldwide. The incidence of this disease in Iran is higher than in other Asian countries. To reduce patients' complications, readmission rates, and health care expenditures, it is necessary to design interventions, which are culturally appropriate and based on community needs. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0039-1685167
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http://dx.doi.org/10.1055/s-0039-1685167DOI Listing
March 2019
2 Reads

Measuring Quality of Life in the Speaker with Dysarthria: Reliability and Validity of the European Portuguese Version of the QoL-DyS.

Folia Phoniatr Logop 2019 Apr 17:1-15. Epub 2019 Apr 17.

Dipartimento di Scienze Biomediche e Cliniche "L. Sacco," Università degli Studi di Milano, Milan, Italy.

Background: The impact of acquired dysarthria on the person's life and social participation is well recognized and is the key to the process of rehabilitation. Evaluation of the effectiveness of an intervention that addresses this impact is a challenge for clinicians and researchers.

Objectives: The purpose of this study was to evaluate the validity and reliability of the European Portuguese version of the Quality of Life in the Speaker with Dysarthria (QoL-DyS). Read More

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http://dx.doi.org/10.1159/000495564DOI Listing

Survival Advantage of African American Dialysis Patients with End-Stage Renal Disease Causes Related to APOL1.

Cardiorenal Med 2019 Apr 17;9(4):212-221. Epub 2019 Apr 17.

Kidney Disease Branch, NIDDK, Bethesda, Maryland, USA,

Background: Observational studies show that African American (AA) dialysis patients have longer survival than European Americans. We hypothesized that apolipoprotein L1 (APOL1) genetic variation, associated with nephropathy in AAs, contributes to the survival advantage in AA dialysis patients.

Methods: We examined the association between race and mortality among 37,097 adult dialysis patients, including 54% AAs and 46% European Americans from a large dialysis organization (entry period from July 2001 to June 2006, follow-up through June 2007), within each cause of end-stage renal disease (ESRD) category associated with APOL1 renal risk variants using Cox proportional hazard models. Read More

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https://www.karger.com/Article/FullText/496472
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http://dx.doi.org/10.1159/000496472DOI Listing
April 2019
1 Read

Gender and Editorial Authorship in High Impact Epidemiology Journals.

Am J Epidemiol 2019 Apr 17. Epub 2019 Apr 17.

Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland.

Women comprise about half of senior epidemiologists, but little is known about whether they are also viewed as leaders (i.e., authorities) in the field. Read More

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http://dx.doi.org/10.1093/aje/kwz094DOI Listing

Effects of dietary energy and protein content and lipid source on growth performance and carcass traits in Pekin ducks.

Poult Sci 2019 Apr 17. Epub 2019 Apr 17.

State Key Laboratory of Animal Nutrition, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, PR China.

The present study was conducted to determine the impact of dietary energy and protein concentrations and lipid sources on growth performance and carcass traits of Pekin ducks. In Exp. 1, 15-day-old ducks (6 replicate pens, 60 ducks/pen) were randomly assigned to 4 dietary treatments with different metabolizable energy (ME) and crude protein (CP) concentrations (2,850 kcal/kg and 16%, 2,950 kcal/kg and 16. Read More

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http://dx.doi.org/10.3382/ps/pez217DOI Listing

Local adaptation in natural European host grass populations with asymmetric symbiosis.

PLoS One 2019 17;14(4):e0215510. Epub 2019 Apr 17.

Natural Resources Institute Finland (Luke), Turku, Finland.

Recent work on microbiomes is revealing the wealth and importance of plant-microbe interactions. Microbial symbionts are proposed to have profound effects on fitness of their host plants and vice versa, especially when their fitness is tightly linked. Here we studied local adaptation of host plants and possible fitness contribution of such symbiosis in the context of abiotic environmental factors. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215510PLOS
April 2019
1 Read

The Development and Validation of the LIMPRINT Methodology.

Lymphat Res Biol 2019 Apr;17(2):127-134

2 Montpellier Medecine Vasculaire, EA2992, Universite Montpellier I, CHU Saint Eloi, Montpellier, France.

The acronym Limprint stands for Lymphedema IMpact and PRevalence INTernational and was run under the auspices of the International Lymphedema Framework (ILF), a charity dedicated to improving provision of care globally. The primary aim was to identify the number of people with chronic edema (chronic edema present for >3 months and due to a range of underlying etiologies and associated risk factors) within diverse health services in nine participating countries and to determine its impact using validated methods. An international protocol and sampling framework, online data capture system, and standard operating procedures were adopted. Read More

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https://www.liebertpub.com/doi/10.1089/lrb.2018.0081
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http://dx.doi.org/10.1089/lrb.2018.0081DOI Listing
April 2019
1 Read

Concentration and Prevalence of Aflatoxin M in Human Breast Milk in Iran: Systematic Review, Meta-Analysis, and Carcinogenic Risk Assessment: A Review.

J Food Prot 2019 Apr 15:785-795. Epub 2019 Apr 15.

8 Department of Food Science, Faculty of Food Engineering, University of Campinas, Rua Monteiro Lobato 80, 13083-862 Campinas, São Paulo, Brazil (ORCID: https://orcid.org/0000-0001-5769-0004 ).

This meta-analysis was designed to review the published reports regarding the concentration and/or prevalence of aflatoxin M (AFM) in human breast milk in Iran. The carcinogenic risk for Iranian infants consuming this milk was estimated with the hazard index. The PubMed and Scopus databases and the Scientific Information Database were screened for relevant studies between 1995 and 2017, and 11 of the 112 collected studies were included in the systematic review and meta-analysis. Read More

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http://dx.doi.org/10.4315/0362-028X.JFP-18-367DOI Listing

The Unique Protein Composition of Honey Revealed by Comprehensive Proteomic Analysis: Allergens, Venom-like Proteins, Antibacterial Properties, Royal Jelly Proteins, Serine Proteases, and Their Inhibitors.

J Nat Prod 2019 Apr 17. Epub 2019 Apr 17.

Proteomics Core Facility, Faculty of Science , Charles University , BIOCEV, Prumyslova 595 , Vestec , CZ-25242 , Czechia.

Honey is a unique natural product produced by European honeybees. Due to its high economic value, honey is considered to be well characterized chemically, and it is often discovered to be an adulterated commodity. However, this study shows that our knowledge of honey protein composition, which is of high medical and pharmaceutical importance, is incomplete. Read More

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http://dx.doi.org/10.1021/acs.jnatprod.8b00968DOI Listing

Preparation, Crystal Chemistry, and Hidden Magnetic Order in the Family of Trigonal Layered Tellurates AMn(4+)TeO (A = Li, Na, Ag, or Tl).

Inorg Chem 2019 Apr 17. Epub 2019 Apr 17.

Physics Faculty , M. V. Lomonosov Moscow State University , Moscow 119991 , Russia.

We report the first four magnetic representatives of the trigonal layered AM(4+)TeO (here, M = Mn) family. NaMnTeO was synthesized from NaMnO, NaNO, and TeO at 650-720 °C, but analogues for which A = Li and K could not be obtained by direct synthesis. However, those for which A = Li, Ag, and Tl (but not K) were prepared by exchange reactions between NaMnTeO and the corresponding molten nitrates. Read More

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http://dx.doi.org/10.1021/acs.inorgchem.8b03445DOI Listing

Chemistry of Layered Pnictogens: Phosphorus, Arsenic, Antimony, and Bismuth.

Angew Chem Int Ed Engl 2019 Apr 17. Epub 2019 Apr 17.

Department of Inorganic Chemistry, University of Chemistry and Technology Prague, Technicka 5, 166 28, Prague 6, Czech Republic.

Materials with few layers have been subjected to extensive research for the last few decades owing to their remarkable properties as for example catalysts, optical and electrical devices, or sensors. The properties and electronic structure of these materials can be tailored by the introduction of substituents. In the case of more reactive species, the modification also can improve stability, which is also an important factor with respect to device fabrication. Read More

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http://dx.doi.org/10.1002/anie.201900811DOI Listing

The genetic relationship between alcohol consumption and aspects of problem drinking in an ascertained sample.

Alcohol Clin Exp Res 2019 Apr 17. Epub 2019 Apr 17.

Washington University School of Medicine, Department of Psychiatry, St. Louis, MO, USA.

Background: Genome-wide association studies (GWAS) have begun to identify loci related to alcohol consumption, but little is known about whether this genetic propensity overlaps with specific indices of problem drinking in ascertained samples.

Methods: In 6,731 European-Americans who had been exposed to alcohol, we examined whether polygenic risk scores (PRS) from a GWAS of weekly alcohol consumption in the UK Biobank predicted variance in 6 alcohol-related phenotypes: alcohol use, maximum drinks within 24 hours (MAXD), total score on the self-rating of effects of ethanol questionnaire (SRE-T), DSM-IV alcohol dependence (DSM4AD), DSM-5 alcohol use disorder symptom counts (DSM5AUDSX), and reduction/cessation of problematic drinking. We also examined the extent to which an SNP (rs1229984) in ADH1B, which is strongly associated with both alcohol consumption and dependence, contributed to the polygenic association with these phenotypes and whether PRS interacted with sex, age, or family history of alcoholism to predict alcohol-related outcomes. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/acer.14064
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http://dx.doi.org/10.1111/acer.14064DOI Listing
April 2019
2 Reads

Endoscopic Resections in Inflammatory Bowel Disease: A Multicentre European Outcomes Study.

J Crohns Colitis 2019 Apr 17. Epub 2019 Apr 17.

Department of Gastroenterology, Queen Alexandra Hospital, Southwick Hill Road, Portsmouth.

Background: Inflammatory bowel disease is associated with an increased risk of colorectal cancer, with estimates ranging from 2-18%, depending on the duration of colitis. The management of neoplasia in colitis remains controversial. Current guidelines recommend endoscopic resection if the lesion is clearly visible with distinct margins. Read More

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https://academic.oup.com/ecco-jcc/advance-article/doi/10.109
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http://dx.doi.org/10.1093/ecco-jcc/jjz075DOI Listing
April 2019
1 Read

Association of Rare Copy Number Variants With Risk of Depression.

JAMA Psychiatry 2019 Apr 17. Epub 2019 Apr 17.

MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, Wales, United Kingdom.

Importance: The role of large, rare copy number variants (CNVs) in neuropsychiatric disorders is well established, but their association with common psychiatric disorders, such as depression, remains unclear.

Objective: To examine the association of a group of 53 CNVs associated with neurodevelopmental disorders and burden of rare CNVs with risk of depression.

Design, Setting, And Participants: This case-control study used data from the UK Biobank study sample, which comprised 502 534 individuals living in the United Kingdom. Read More

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http://dx.doi.org/10.1001/jamapsychiatry.2019.0566DOI Listing

Dual platelet antiaggregation therapy after myocardial revascularization surgery.

Rev Assoc Med Bras (1992) 2019 Mar 11;65(3):316-318. Epub 2019 Apr 11.

Department of Atherosclerosis of the Heart Institute of the Hospital das Clínicas of the Faculty of Medicine of the University of São Paulo, São Paulo, Brasil.

Coronary artery bypass graft (CABG) is a consolidated treatment in patients with coronary artery disease (CAD) for both symptom control and improvement of prognosis. The patency of venous grafts is still the most vulnerable point of the surgical treatment since it presents a high prevalence of occlusion both in the immediate postoperative period and in the long-term follow-up. Aspirin plays a well-established role in this setting, and for a long time, clopidogrel use has been restricted to patients allergic to aspirin. Read More

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http://dx.doi.org/10.1590/1806-9282.65.3.316DOI Listing

Do drinking problems in the past affect current consumption?

Cad Saude Publica 2019 8;35(4):e00025618. Epub 2019 Apr 8.

Centre for Business and Economics Research, Coimbra, Portugal.

Harmful use of alcohol ranks among the top five risk factors for disease, disability and death worldwide. However, not all individuals who consume alcohol throughout life are addicted and our premise is that addiction implies a chain of consumption that produces harmful effects. The objective of this study was to evaluate whether self-assessed past drinking problems - our measure of harmful alcohol consumption - affect the current alcohol consumption patterns. Read More

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http://dx.doi.org/10.1590/0102-311X00025618DOI Listing

Prevalence of sarcopenia and its associated factors: the impact of muscle mass, gait speed, and handgrip strength reference values on reported frequencies.

Clinics (Sao Paulo) 2019 Apr 8;74:e477. Epub 2019 Apr 8.

Laboratorio de Envelhecimento Humano - GeronLab, Faculdade de Ciencias Medicas, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, BR.

Objectives: Sarcopenia is a common treatable geriatric condition. The aim of this study was to estimate the prevalence of sarcopenia and its associated factors in community-dwelling elderly living in Rio de Janeiro, Brazil, and to discuss the impact of different muscle mass, handgrip strength and gait speed cut-off values on the reported frequency of sarcopenia.

Methods: The health habits, functional capacity, and anthropometric measurements of 745 individuals aged ≥65 years from the Frailty in Brazilian Older People study were analyzed. Read More

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http://dx.doi.org/10.6061/clinics/2019/e477DOI Listing

[Some comments on the 2017 European Guidelines on treatment of atherosclerotic lesions of brachiocephalic arteries].

Authors:
D F Beloiartsev

Angiol Sosud Khir 2019 ;25(1):109-114

Vascular Surgery Department, National Medical Research Centre of Surgery named after A.V. Vishnevsky under the RF Ministry of Public Health, Moscow, Russia.

Analysed herein are the indications for primary interventions in patients with atherosclerotic lesions of internal carotid arteries according to the recommendations laid down in the 2017 Guidelines of the European Society for Vascular Surgery. Read More

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http://dx.doi.org/10.33529/angio2019115DOI Listing
January 2019

Polygenic risk scores in coronary artery disease.

Curr Opin Cardiol 2019 Apr 15. Epub 2019 Apr 15.

Division of Cardiovascular Medicine and Cardiovascular Institute, Stanford University, Stanford, California, USA.

Purpose Of Review: Large genome-wide association studies (GWAS) have identified variants accounting for a substantial portion of the heritable risk for coronary artery disease (CAD). These studies have not only catalyzed drug discovery but also have opened the possibility of improved risk prediction and stratification. Here we review the current state-of-the art in polygenic risk scores (PRSs) and look to the future, as these scores move towards clinical application. Read More

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http://dx.doi.org/10.1097/HCO.0000000000000629DOI Listing

The BIOFLOW-III Italian Satellite Registry: 18-month results of the Orsiro stent in an all-comer high-risk population.

J Cardiovasc Med (Hagerstown) 2019 Apr 15. Epub 2019 Apr 15.

Division of Cardiology, Presidio Ospedaliero Di Venere, Bari Carbonara, Italy.

Aims: We aimed to corroborate clinical evidence on the safety and efficacy of the ultrathin-strut biodegradable-polymer sirolimus-eluting Orsiro stent in an all-comer population including high-risk subgroups.

Methods: The nationwide, prospective, all-comer BIOFLOW-III Satellite Registry was conducted at 18 Italian sites. High-risk subgroups [diabetes, small vessels (≤2. Read More

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http://dx.doi.org/10.2459/JCM.0000000000000795DOI Listing
April 2019
1 Read

Helicobacter pylori and hematological disorders.

Minerva Gastroenterol Dietol 2019 Apr 16. Epub 2019 Apr 16.

Hematology, AOU Città della Scienza e della Salute, Turin, Italy.

Helicobacter pylori (H. pylori) is one of the most common worldwide infection, which can affect adults as children. The prevalence of this bacterium is variable in different countries, depending on various hygienic and socioeconomic conditions and living customs. Read More

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https://www.minervamedica.it/index2.php?show=R08Y9999N00A190
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http://dx.doi.org/10.23736/S1121-421X.19.02580-7DOI Listing
April 2019
1 Read

Coping strategies in young and adult haemophilia patients: A tool for the adaptation to the disease.

Haemophilia 2019 Apr 17. Epub 2019 Apr 17.

Department of Basic Psychology and Methodology, Faculty of Psychology, University of Murcia, Murcia, Spain.

Introduction: Chronic diseases, after diagnosis, involve changes that have to favour coping with the new situation. The resources used will help control, manage and adapt to the disease. The psychological aspects may be influencing how the individual faces the situation. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/hae.13743
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http://dx.doi.org/10.1111/hae.13743DOI Listing
April 2019
1 Read

Judicialization of the right to health: (Un)compliance of the judicial decisions in Medellin, Colombia.

Int J Health Plann Manage 2019 Apr 17. Epub 2019 Apr 17.

Global Health and Tropical Medicine (GHTM), Unidade de Saúde Pública Internacional e Bioestatística, Instituto de Higiene e Medicina Tropical (IHMT), Universidade Nova de Lisboa, Lisbon, Portugal.

Introduction: The judicialization of health arose following the possibility of judicially demanding the right to health before national and international courts. In the case of Colombia, health litigation is done through a constitutional tool called the tutela action, which allows for the immediate protection of fundamental rights.

Methods: A retrospective cross-sectional study using a probabilistic stratified sample of 1031 users of the tutela actions, in Medellín, Colombia, between 2011 and 2014. Read More

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http://dx.doi.org/10.1002/hpm.2793DOI Listing

Classic galactosaemia in the Greek Cypriot population: An epidemiological and molecular study.

Ann Hum Genet 2019 Apr 17. Epub 2019 Apr 17.

Department of Biochemical Genetics, The Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus.

Classic galactosaemia is an inherited metabolic disorder of galactose metabolism caused by deficiency of the enzyme galactose-1-phosphate uridyltransferase (GALT) resulting from mutations in the GALT gene. The objectives of the present study were the determination of the carrier frequency of classic galactosaemia in the Greek Cypriot population and the molecular characterization of the disease alleles. We performed an epidemiological study involving 528 Greek Cypriots originating from all parts of Cyprus. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/ahg.12318
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http://dx.doi.org/10.1111/ahg.12318DOI Listing
April 2019
1 Read

Four Italian experiences on vaccination policies: results and lessons.

Ann Ig 2019 Mar-Apr;31(2 Supple 1):36-44

School of Medicine, University Vita-Salute San Raffaele, Milan, Italy.

Introduction: In 2018 the Council of Europe adopted a Recommendation on strengthened cooperation against vaccine preventable diseases. Among EU Member States, Italy has a long-lasting tradition of immunization policies implemented in the context of the National Health Service over the last forty years.

Methods: We identify, report and critically appraise four immunization strategies implemented in Italy in recent years and quantitatively assess their impact on coverage rates and other selected indicators. Read More

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http://dx.doi.org/10.7416/ai.2019.2275DOI Listing
April 2019
2 Reads

Group A rotavirus surveillance before vaccine introduction in Italy, September 2014 to August 2017.

Euro Surveill 2019 Apr;24(15)

The members of the RotaNet-Italy Study Group who contributed data are listed at the end of this article.

IntroductionGroup A rotaviruses (RVA) are the leading cause of acute gastroenteritis (AGE) in young children, causing ca 250,000 deaths worldwide, mainly in low-income countries. Two proteins, VP7 (glycoprotein, G genotype) and VP4 (protease-sensitive protein, P genotype), are the basis for the binary RVA nomenclature. Although 36 G types and 51 P types are presently known, most RVA infections in humans worldwide are related to five G/P combinations: G1P[8], G2P[4], G3P[8], G4P[8], G9P[8]. Read More

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http://dx.doi.org/10.2807/1560-7917.ES.2019.24.15.1800418DOI Listing

New and old biomarkers in the differential diagnosis of lung cancer: Pro-gastrin-releasing peptide in comparison with neuron-specific enolase, carcinoembryonic antigen, and CYFRA 21-1.

Int J Biol Markers 2019 Apr 17:1724600819834235. Epub 2019 Apr 17.

5 Division of Laboratory Medicine, Humanitas Clinical and Research Center, IRCCS, Rozzano Milan, Italy.

Background: Testing for circulating biomarkers in lung cancer is hampered by the insufficient specificity. We aimed to assess the relative diagnostic accuracy of pro-gastrin-releasing peptide (ProGRP) for the differential diagnosis of small cell lung cancer and compare it with more conventional biomarkers.

Methods: We enrolled a cohort of 390 patients with a clinical suspicion of lung cancer and for whom a histologic assessment was available. Read More

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http://dx.doi.org/10.1177/1724600819834235DOI Listing

Stability studies of rifampicin in plasma and urine of tuberculosis patients according to the European Medicines Agency Guidelines.

Bioanalysis 2019 Apr 17. Epub 2019 Apr 17.

Medical Officer, Dr Harisingh Gour Vishwavidyalaya (A Central University), Sagar, Madhya Pradesh, India.

The macrolide antibiotic rifampicin is prescribed against several infections, like tuberculosis disease. This drug decays to rifampicin quinone. The biological fluids were diluted in a micellar solution and directly injected. Read More

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http://dx.doi.org/10.4155/bio-2018-0174DOI Listing

Cell Encapsulation in Soft, Anisometric Poly(ethylene) Glycol Microgels Using a Novel Radical-Free Microfluidic System.

Small 2019 Apr 16:e1900692. Epub 2019 Apr 16.

DWI-Leibniz Institute for Interactive Materials, Forckenbeckstrasse 50, 52074, Aachen, Germany.

Complex 3D artificial tissue constructs are extensively investigated for tissue regeneration. Frequently, materials and cells are delivered separately without benefitting from the synergistic effect of combined administration. Cell delivery inside a material construct provides the cells with a supportive environment by presenting biochemical, mechanical, and structural signals to direct cell behavior. Read More

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http://dx.doi.org/10.1002/smll.201900692DOI Listing

Integrating genetic mutations and expression profiles for survival prediction of lung adenocarcinoma.

Thorac Cancer 2019 Apr 16. Epub 2019 Apr 16.

Stem Cell Translational Research Center, Tongji Hospital, Tongji University School of Medicine, Shanghai, China.

Background: Lung adenocarcinoma (LUAD) is a set of heterogeneous diseases with distinct genetic and transcriptomic characteristics. Since the introduction of the 2011 International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society histologic classification, increasing evidence has provided insights into genomic mutations and rearrangements among individual histologic subtypes of LUAD. However, how genotypic and phenotypic features of LUAD are interconnected is not well understood. Read More

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http://dx.doi.org/10.1111/1759-7714.13072DOI Listing

Diagnostic accuracy of left atrial remodelling and natriuretic peptide levels for preclinical heart failure.

ESC Heart Fail 2019 Apr 16. Epub 2019 Apr 16.

Department of Medicine, Mackay Medical College, New Taipei City, Taiwan.

Aims: Left atrial (LA) remodelling is an important predictor of cardiovascular events of heart failure (HF) and atrial fibrillation. Data regarding diagnostic value of LA remodelling on diastolic dysfunction (DD) and preclinical HF remain largely unexplored.

Methods And Results: We assessed LA dimension (LAD) in 8368 consecutive asymptomatic Asians (mean age: 49. Read More

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http://dx.doi.org/10.1002/ehf2.12430DOI Listing

HPV-vaccination and cancer cervical screening in 53 WHO European Countries: An update on prevention programs according to income level.

Cancer Med 2019 Apr 16. Epub 2019 Apr 16.

Local Health Unit, Teramo, Italy.

Human papillomavirus (HPV) is the most common sexually transmitted disease in the world. The aim of our study is to describe the differences in HPV-vaccination coverage and screening programs in WHO European Countries notably according to income levels. Multiple correspondence analysis was applied to examine the association among the following variables: Gross National Income (GNI) levels (Lower-Middle Income, LMI; Upper-Middle Income, UMI; and High Income, HI); type of CC screening program (coverage; opportunistic/organized); vaccination payment policies (free or partial or total charge); mortality rates/100 000 (≤3; >3-6; >6-9; >9); incidence rates/100 000 (≤7; >7-15; >15-21; >21). Read More

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http://dx.doi.org/10.1002/cam4.2048DOI Listing

Sarcopenia and its association with falls and fractures in older adults: A systematic review and meta-analysis.

J Cachexia Sarcopenia Muscle 2019 Apr 16. Epub 2019 Apr 16.

Department of Human Movement Sciences, @AgeAmsterdam, Faculty of Behavioural and Movement Sciences, Amsterdam Movement Sciences, Vrije Universiteit, Amsterdam, The Netherlands.

Sarcopenia is a potentially modifiable risk factor for falls and fractures in older adults, but the strength of the association between sarcopenia, falls, and fractures is unclear. This study aims to systematically assess the literature and perform a meta-analysis of the association between sarcopenia with falls and fractures among older adults. A literature search was performed using MEDLINE, EMBASE, Cochrane, and CINAHL from inception to May 2018. Read More

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http://dx.doi.org/10.1002/jcsm.12411DOI Listing

Summary of the Second Congress of the International Society for Apheresis-European Group and the Austrian Apheresis Association.

Ther Apher Dial 2018 Aug;22(4):317-318

President, Austrian Apheresis Association, ATHOS Institute, Vienna, Austria.

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http://dx.doi.org/10.1111/1744-9987.12722DOI Listing

Resident Burnout in United States and European Urology Residents: An International Concern.

BJU Int 2019 Apr 16. Epub 2019 Apr 16.

MedStar Washington Hospital Center, Department of Urology.

Background: Although the rate of burnout in urologists is high and associated with severe negative sequelae, the extent and predictors of burnout in urology trainees remains poorly understood OBJECTIVE: To describe the prevalence and predictors of burnout in US and European urology residents.

Material And Methods: Anonymous 32-question survey of urology trainees across the US and 4 European countries analyzing personal, program and institutional factors. Burnout was assessed using the validated abridged Maslach Burnout Inventory. Read More

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http://dx.doi.org/10.1111/bju.14774DOI Listing

Aerobic capacity correlates with health-related quality of life after breast cancer surgery.

Eur J Cancer Care (Engl) 2019 Apr 16:e13050. Epub 2019 Apr 16.

Department of Rehabilitation Medicine, Catholic Kwandong University International St Mary's Hospital, Incheon, Korea.

To investigate the relation of physical functions to health-related quality of life (HRQOL), physical activity and fatness of patients during breast cancer treatment within 1 year after surgery. We retrospectively reviewed the patients with breast cancer at the cancer rehabilitation clinic within 1 year after surgery. Physical function assessment included aerobic capacity, muscle strength, flexibility and oedema. Read More

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http://dx.doi.org/10.1111/ecc.13050DOI Listing

Impact of combined healthy lifestyle factors on survival in an adult general population and in high-risk groups: prospective results from the Moli-sani Study.

J Intern Med 2019 Apr 16. Epub 2019 Apr 16.

Department of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli, IS, Italy.

Background: There is poor knowledge on the association between combined lifestyles with mortality risk among individuals at high risk, and little is known on the biological mechanisms that could be on the pathway.

Methods: Longitudinal analysis on 22 839 individuals from the Moli-sani Study (Italy, 2005-2010). Among them, we identified 5200 elderly individuals (≥65 year), 2127 subjects with diabetes and 1180 with cardiovascular disease (CVD) at baseline. Read More

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http://dx.doi.org/10.1111/joim.12907DOI Listing

Artificial Microbial Arenas: Materials for Observing and Manipulating Microbial Consortia.

Adv Mater 2019 Apr 16:e1900284. Epub 2019 Apr 16.

Microverse Cluster, Friedrich Schiller University Jena, Neugasse 23, 07743, Jena, Germany.

From the smallest ecological niche to global scale, communities of microbial life present a major factor in system regulation and stability. As long as laboratory studies remain restricted to single or few species assemblies, however, very little is known about the interaction patterns and exogenous factors controlling the dynamics of natural microbial communities. In combination with microfluidic technologies, progress in the manufacture of functional and stimuli-responsive materials makes artificial microbial arenas accessible. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/adma.2019002
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http://dx.doi.org/10.1002/adma.201900284DOI Listing
April 2019
1 Read

Medical Algorithm: Diagnosis and Treatment of Chronic Rhinosinusitis.

Allergy 2019 Apr 16. Epub 2019 Apr 16.

Upper Airway Research Laboratory, Ghent University Hospital, Dep. of Otorhinolaryngology, Ghent, Belgium.

Chronic rhinosinusitis (CRS) is a disease affecting more than 10% of the European population, causing symptoms and impacting quality of life. CRS is classically differentiated into disease without and with nasal polyps (CRSsNP, CRSwNP) based on clinical signs, specifically using nasal endoscopy for diagnosis (1). However, the differentiation into phenotypes allows to conclude on dominant remodelling patterns (fibrosis in CRSsNP or oedema and polyp formation in CRSwNP), but does only partly predict the natural course of disease; phenotypes do not adequately appreciate the current discussion about different surgical approaches or innovative biologics. Read More

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http://dx.doi.org/10.1111/all.13823DOI Listing

Treatment in childhood central nervous system demyelinating disorders.

Dev Med Child Neurol 2019 Apr 16. Epub 2019 Apr 16.

Department of Pediatric Neurology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.

The last two decades witnessed significant advances in the treatment of acquired demyelinating disorders: thirteen new agents have been approved for the treatment of multiple sclerosis in adults by the European Medicines Agency and US Food and Drug Administration in the last twenty years. Although the long-term efficacy and safety profiles of some new drugs are still being assessed in paediatric MS, clinicians may have to use them in the management of paediatric onset MS resistant to first-line medications, based on results obtained in adult-onset disease. This review summarizes the current approach to treatment in children with demyelinating syndromes. Read More

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http://dx.doi.org/10.1111/dmcn.14228DOI Listing

Practical guidance for engaging patients in health research, treatment guidelines and regulatory processes: results of an expert group meeting organized by the World Health Organization (WHO) and the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO).

Aging Clin Exp Res 2019 Apr 16. Epub 2019 Apr 16.

WHO Collaborating Centre for Public Health Aspects of Musculoskeletal Health and Aging, Liège, Belgium.

There is increasing emphasis on patient-centred research to support the development, approval and reimbursement of health interventions that best meet patients' needs. However, there is currently little guidance on how meaningful patient engagement may be achieved. An expert working group, representing a wide range of stakeholders and disciplines, was convened by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) and the World Health Organization (WHO). Read More

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http://dx.doi.org/10.1007/s40520-019-01193-8DOI Listing

Correction to: PyPNS: Multiscale Simulation of a Peripheral Nerve in Python.

Neuroinformatics 2019 Apr 16. Epub 2019 Apr 16.

Department of Bioengineering, Imperial College London, South Kensington, London, SW7 2AZ, UK.

The original version of this article unfortunately contained a mistake. The following text: "This project has received funding from European Research Council (ERC) Synergy Grant no. 319818. Read More

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http://dx.doi.org/10.1007/s12021-019-09421-2DOI Listing

Comparison and optimization of different methods for Microcystis aeruginosa's harvesting and the role of zeta potential on its efficiency.

Environ Sci Pollut Res Int 2019 Apr 16. Epub 2019 Apr 16.

CEB-Centre of Biological Engineering, University of Minho, Braga, Portugal.

This study has compared the harvesting efficiency of four flocculation methods, namely, induced by pH, FeCl, AlCl and chitosan. No changes were observed on M. aeruginosa cells. Read More

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http://dx.doi.org/10.1007/s11356-019-04803-0DOI Listing

High level of clinical inertia in insulin initiation in type 2 diabetes across Central and South-Eastern Europe: insights from SITIP study.

Acta Diabetol 2019 Apr 16. Epub 2019 Apr 16.

Department of Endocrinology, Diabetes and Metabolic Diseases, University Medical Centre, Ljubljana, Slovenia.

Aims: Little is known regarding initiation of insulin therapy in type 2 diabetes (T2D) in Central and South-Eastern European countries. Therefore, we conducted a survey to characterise the prescribing practices of specialist diabetes healthcare professionals in this region and assessed factors that influence clinical decision-making regarding insulin initiation in T2D.

Methods: A cross-sectional survey sampled 211 specialist diabetes healthcare prescribers from five Central and South-Eastern European countries (Bulgaria, Croatia, Greece, Hungary, and Slovenia). Read More

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http://dx.doi.org/10.1007/s00592-019-01346-1DOI Listing

Absolute basophil count is associated with time to recurrence in patients with high-grade T1 bladder cancer receiving bacillus Calmette-Guérin after transurethral resection of the bladder tumor.

World J Urol 2019 Apr 16. Epub 2019 Apr 16.

Department of Clinical Medicine and Surgery, Federico II University of Naples, Naples, Italy.

Background: Basophils, eosinophils and monocytes may be involved in BCG-induced immune responses and be associated with outcomes of bladder cancer patients receiving intravesical BCG. Our objective was to explore the association of baseline counts of basophils, eosinophils and monocytes with outcomes of patients with high-grade T1 bladder cancer receiving a standard course of intravesical BCG.

Methods: We retrospectively reviewed medical records of patients with primary T1 HG/G3 bladder cancer. Read More

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http://dx.doi.org/10.1007/s00345-019-02754-2DOI Listing

Incidence and excess mortality of hip fractures in a predominantly Caucasian population in the South of Brazil.

Arch Osteoporos 2019 Apr 16;14(1):47. Epub 2019 Apr 16.

Endocrine Center of UFPR, Universidade Federal do Paraná, Curitiba, Brazil.

Introduction: Osteoporosis is a very common disease, and data on its epidemiology is important for health care strategy implementation. Brazil is a developing country; its population is aging, leading to an expected increase in hip fractures and their undesirable consequences.

Objective: Assess the incidence of osteoporotic hip fractures and subsequent mortality in Southern Brazil as part of a large epidemiological study aiming to reinforce the data for FRAX Brazil. Read More

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http://dx.doi.org/10.1007/s11657-019-0597-yDOI Listing

Research driving innovation: what are key factors for successful integration of translational science into oncology care concepts? 5th European Roundtable Meeting (ERTM) May 4th, 2018, Berlin, Germany.

J Cancer Res Clin Oncol 2019 Apr 16. Epub 2019 Apr 16.

German Cancer Society, Berlin, Germany.

Purpose: To identify key factors for successful integration of translational science into cancer care.

Results: Organisation of the health care system matters to optimally bridge between public and private cancer research, cancer registries and routine care. Currently, there are deficits on various levels of connectivity. Read More

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http://dx.doi.org/10.1007/s00432-019-02916-0DOI Listing

Will worker DNELs derived under the European REACH regulation extend the landscape of occupational exposure guidance values?

Arch Toxicol 2019 Apr 16. Epub 2019 Apr 16.

Integrative Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

Derived no-effect levels for workers (wDNELs) under the European REACH legislation have many aspects in common with occupational exposure limits (OELs). In an attempt to examine under which circumstances wDNELs might be used as exposure guidance outside their intended application, we compared derivation methods, coverage of substances and numerical values of wDNELs against two regulatory OEL lists (European Commission and Sweden) and three sets of recommendations (European SCOEL, German MAK and US ACGIH). Finally, we looked closer at wDNELs where SCOEL concluded that data were insufficient to derive an OEL. Read More

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http://dx.doi.org/10.1007/s00204-019-02439-0DOI Listing