16 results match your criteria European Journal of Hospital Pharmacy[Journal]

  • Page 1 of 1

Rapid acting fentanyl formulations in breakthrough pain in cancer. Drug selection by means of the System of Objectified Judgement Analysis.

Eur J Hosp Pharm Sci Pract 2018 May 11;25(3):e2. Epub 2017 Jan 11.

Faculty of Medicine, Department of Cancer Research and Molecular Medicine, European Palliative Care Research Centre (PRC), Norwegian University of Science and Technology (NTNU) and St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.

Drug selection of rapid acting fentanyl formulations in the treatment of breakthrough pain in patients with cancer is performed by the System of Objectified Judgement Analysis method. All seven available formulations were included in the analysis. The following selection criteria were used: number of available strengths, variability in the rate of absorption, interactions, clinical efficacy, side effects, ease of administration and documentation. Read More

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http://dx.doi.org/10.1136/ejhpharm-2016-001127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931243PMC
May 2018
11 Reads

Evaluation of the physicochemical and biological stability of reconstituted and diluted SB2 (infliximab).

Eur J Hosp Pharm Sci Pract 2018 May 13;25(3):157-164. Epub 2017 Jan 13.

Quality Evaluation Team, Samsung Bioepis Co., Ltd, Incheon, Republic of Korea.

Objectives: To evaluate the critical quality attributes that might affect the stability of an infliximab biosimilar (SB2, Flixabi) when reconstituted or diluted and stored under refrigeration and at room temperature.

Methods: We largely adhered to the UK's National Health Service guidance requirements for the design of a robust stability study and for robust testing methods. Protocol components included evaluation of visual appearance, chemical stability, physical stability, pH, particle sizes and biological activity. Read More

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http://dx.doi.org/10.1136/ejhpharm-2016-001085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931250PMC
May 2018
10 Reads

Medication practice in hospitals: are nanosimilars evaluated and substituted correctly?

Eur J Hosp Pharm Sci Pract 2018 Mar 23;25(2):79-84. Epub 2017 Jan 23.

Vifor Pharma Ltd., Glattbrugg, Switzerland.

Introduction: This study investigates the drug selection and dispensing behaviour of hospital pharmacists of intravenous iron products including iron sucrose and iron sucrose similar, with special emphasis on substitution and interchangeability in France and Spain. Iron-carbohydrate complex drugs represent different available intravenous iron drugs and are part of the non-biological complex drug (NBCD) class, an expanding drug class with up to 30 brands available in intravenous pharmacotherapy and over 50 in clinical development. Follow-on versions of iron sucrose have appeared in some markets such as France and Spain, which were authorised by the generic approval pathway. Read More

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http://dx.doi.org/10.1136/ejhpharm-2016-001059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5868288PMC
March 2018
8 Reads

The European Falsified Medicines Directive in Poland: background, implementation and potential recommendations for pharmacists.

Eur J Hosp Pharm Sci Pract 2018 Jan 27;25(1):10-15. Epub 2016 Jul 27.

Said Business School, University of Oxford, Oxford, UK.

By February 2019, the Polish pharmaceutical industry, community and hospital pharmacies, wholesalers and parallel traders must all comply with the EU-wide Falsified Medicines Directive (FMD) legislation (2011/62/EU), to ensure that no medicinal product is dispensed to a patient without proper tracking and authentication. Here we describe how Poland is complying with the new EU regulations, the actions that have been taken to incorporate the FMD into Polish Pharmaceutical Law and whether or not these actions are sufficient. We found that Poland is only partially compliant with the FMD and further actions need to be undertaken to fully meet the Delegated Act (DA) requirements. Read More

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http://dx.doi.org/10.1136/ejhpharm-2016-000970DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5750370PMC
January 2018
14 Reads

Mandatory dexamethasone strictly monitored by pharmacists reduces the severity of pemetrexed-induced skin rash.

Eur J Hosp Pharm Sci Pract 2017 Sep 3;24(5):283-285. Epub 2016 Aug 3.

Department of Thoracic Malignancy, Osaka Prefectural Medical Center for Respiratory and Allergic Diseases, Habikino City, Osaka, Japan.

Objective: The present study aimed to retrospectively examine the effectiveness of mandatory dexamethasone (m-DEX) strictly monitored by pharmacists collaborating with medical physicians and nurses for reducing pemetrexed (PEM)-induced skin rash in patients with non-squamous non-small-cell lung cancer (ns-NSCLC).

Methods: We compared the rash grades during the first cycle of PEM-containing regimens between patients who received m-DEX after February 2012 and those who received dexamethasone (DEX) at their physician's discretion (d-DEX) before January 2012.

Results: Of 163 patients with ns-NSCLC included in this study, 89 received d-DEX and 74 received m-DEX. Read More

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http://dx.doi.org/10.1136/ejhpharm-2016-000957DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5739825PMC
September 2017
18 Reads

Deprescribing medicines in the acute setting to reduce the risk of falls.

Eur J Hosp Pharm Sci Pract 2017 Jan 19;24(1):10-15. Epub 2016 Aug 19.

NIHR CLAHRC NWL, Imperial College London, London, UK; Institute of Pharmaceutical Sciences, King's College London, London, UK.

Background: Falls are a common cause of morbidity and hospitalisation in older people. Inappropriate prescribing and polypharmacy contribute to falls risk in elderly patients. This study's aim was to quantify the problem and find out if medication review in the hospital setting led to deprescribing of medicines associated with falls risk. Read More

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http://dx.doi.org/10.1136/ejhpharm-2016-001003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5284469PMC
January 2017
19 Reads

Establishing good authentication practice (GAP) in secondary care to protect against falsified medicines and improve patient safety.

Eur J Hosp Pharm Sci Pract 2016 Mar 1;23(2):118-120. Epub 2015 Oct 1.

Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK; The Oxford-UCL Centre for the Advancement of Sustainable Medical Innovation (CASMI), The University of Oxford, Oxford, UK; Centre for Behavioural Medicine, UCL School of Pharmacy, University College London, London, UK; Harvard Stem Cell Institute, Cambridge, Massachusetts, USA; USCF-Stanford Center of Excellence in Regulatory Science and Innovation (CERSI), USA.

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http://dx.doi.org/10.1136/ejhpharm-2015-000750DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789696PMC
March 2016
18 Reads

Person-centred pharmaceutical care reduces emergency readmissions.

Eur J Hosp Pharm Sci Pract 2016 Mar 1;23(2):80-85. Epub 2015 Oct 1.

Division of Pharmacy , School of Medicine, Pharmacy and Health, Durham University, Queen's Campus, University Boulevard , Thornaby-On-Tees , UK.

Background: Unplanned readmissions to hospital are used in many healthcare systems as a quality indicator of care. Identifying patients at risk of readmission is difficult; existing prediction tools are only moderately sensitive. Correlations exist between certain medicines and emergency readmission, but it is not known whether the association is direct or indirect. Read More

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http://dx.doi.org/10.1136/ejhpharm-2015-000736DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789703PMC
March 2016
14 Reads
0.471 Impact Factor

Diluting ferric carboxymaltose in sodium chloride infusion solution (0.9% w/v) in polypropylene bottles and bags: effects on chemical stability.

Eur J Hosp Pharm Sci Pract 2016 Jan 12;23(1):22-27. Epub 2015 Aug 12.

Vifor Pharma Ltd. , Glattbrugg , Switzerland.

Objectives: This study was designed to assess the physicochemical stability of colloidal ferric carboxymaltose solution (Ferinject) when diluted and stored in polypropylene (PP) bottles and bags for infusion.

Methods: Two batches of ferric carboxymaltose solution (Ferinject) were diluted (500 mg, 200 mg and 100 mg iron in 100 mL saline) in PP bottles or bags under aseptic conditions. The diluted solutions were stored at 30°C and 75%±5% relative humidity (rH) for 72 h, and samples were withdrawn aseptically at preparation and after 24 h, 48 h and 72 h. Read More

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http://dx.doi.org/10.1136/ejhpharm-2015-000697DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4717364PMC
January 2016
49 Reads

A pilot survey of junior doctors' attitudes and awareness around medication review: time to change our educational approach?

Eur J Hosp Pharm Sci Pract 2015 Jul 3;22(4):243-248. Epub 2015 Jun 3.

National Institute of Health Research (NIHR) Collaboration for Leadership in Applied Health Research and Care Northwest London (CLAHRC NWL) , London , UK.

Objectives: Our aim was to explore junior doctors' attitudes and awareness around concepts related to medication review, in order to find ways to change the culture for reviewing, altering and stopping inappropriate or unnecessary medicines. Having already demonstrated the value of team working with senior doctors and pharmacists and the use of a medication review tool, we are now looking to engage first year clinicians and undergraduates in the process.

Method: An online survey about medication review was distributed among all 42 foundation year one (FY1) doctors at the Chelsea and Westminster Hospital NHS Foundation Trust in November 2014. Read More

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http://dx.doi.org/10.1136/ejhpharm-2015-000664DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516007PMC
July 2015
23 Reads

Stability of octreotide acetate decreases in a sodium bisulfate concentration-dependent manner: compatibility study with morphine and metoclopramide injections.

Eur J Hosp Pharm Sci Pract 2015 May 16;22(3):171-175. Epub 2015 Jan 16.

Department of Pharmacy , Saiseikai Takaoka Hospital , Takaoka , Japan.

Purpose: Sodium bisulfate is known to affect the stability of octreotide. However, the critical concentration of sodium bisulfate is not known. Therefore, we assessed the critical concentration of sodium bisulfate needed to preserve the stability of octreotide using actual drugs containing sodium bisulfate. Read More

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http://ejhp.bmj.com/lookup/doi/10.1136/ejhpharm-2014-000555
Publisher Site
http://dx.doi.org/10.1136/ejhpharm-2014-000555DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4431342PMC
May 2015
14 Reads

The feasibility of using dose-banded syringes to improve the safety and availability of patient-controlled opioid analgesic infusions in children.

Eur J Hosp Pharm Sci Pract 2014 Oct 24;21(5):306-308. Epub 2014 Jul 24.

Institute of Pharmaceutical Science, King's College London, King's Health Partners , London , UK ; Pharmacy Department , Evelina London Children's Hospital, Guy's & St Thomas' NHS Foundation Trust, King's Health Partners , London , UK.

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http://dx.doi.org/10.1136/ejhpharm-2014-000441DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4174165PMC
October 2014
16 Reads

Beliefs about medicines among Norwegian outpatients with chronic cardiovascular disease.

Eur J Hosp Pharm Sci Pract 2014 Apr 28;21(2):118-120. Epub 2013 Aug 28.

Department of Health Management and Health Economics , Institute of Health and Society, University of Oslo , Oslo , Norway ; Department of Biostatistics , Institute of Basic Medical Sciences, University of Oslo , Oslo , Norway.

Objective: To investigate the beliefs of Norwegian outpatients about medicines, and to explore if some patient-specific factors and drug use are associated with the beliefs.

Methods: Patients from an outpatient clinic for chronic cardiovascular diseases were referred by physicians to a pharmacist-led medication outpatient clinic. Here the patients were asked to complete the Beliefs about Medicines Questionnaire. Read More

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http://dx.doi.org/10.1136/ejhpharm-2013-000346DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3963598PMC
April 2014
8 Reads

Equivalence and interchangeability of narrow therapeutic index drugs in organ transplantation.

Authors:
Atholl Johnston

Eur J Hosp Pharm Sci Pract 2013 Oct 29;20(5):302-307. Epub 2013 Aug 29.

The calcineurin inhibitors (CNIs), ciclosporin and tacrolimus, are the mainstay of immunosuppression in solid organ transplantation. Generic formulations of these drugs are now available. With increasing pressure on healthcare budgets and the consequent need to match health expectations to available resources, substitution with a generic product appears an attractive option to reduce costs. Read More

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http://dx.doi.org/10.1136/ejhpharm-2012-000258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3786630PMC
October 2013
8 Reads

Cost per patient and potential budget implications of denosumab compared with zoledronic acid in adults with bone metastases from solid tumours who are at risk of skeletal-related events: an analysis for Austria, Sweden and Switzerland.

Eur J Hosp Pharm Sci Pract 2013 Aug 21;20(4):227-231. Epub 2013 Feb 21.

International Health Economics and Reimbursement , Amgen (Europe) GmbH , Zug , Switzerland.

Objectives: To assess cost implications per patient, per year, and to predict the potential annual budget impact when patients with bone metastases secondary to solid tumours at risk of skeletal-related events (SREs) transition from zoledronic acid (ZA; 4 mg every 3-4 weeks) to denosumab (120 mg every 4 weeks) in Austria, Sweden and Switzerland.

Methods: Country specific costs for medication and administration, patient management and SREs (defined as pathologic fracture, radiation to bone, surgery to bone and spinal cord compression) were assessed over a 1-year time horizon. Drug administration and patient management costs were taken from available public sources. Read More

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http://dx.doi.org/10.1136/ejhpharm-2012-000235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3717600PMC
August 2013
47 Reads

Development and validation of an HPLC method to determine the stability of fentanyl citrate and bupivacaine hydrochloride mixtures in infusion solutions.

Eur J Hosp Pharm Sci Pract 2012 Oct;19(5):447-451

Pharmaceutical Chemistry, Karol Marcinkowski University of Medical Sciences, Poznań, Poland ; Inhospital pharmacy, Heliodor Swięcicki Clinical Hospital of PUMS, Poznań, Poland.

Background: The use of a combination of different drugs in postoperative analgesia extends the time of analgesia, makes it more efficient and allows the use of lower drug doses, which leads to less risk of side effects and drug dependence. The aim of this study was to develop and validate an HPLC method to determine the stability of fentanyl citrate and bupivacaine hydrochloride mixtures in standard infusion solutions of 0.9% sodium chloride and 5% glucose. Read More

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http://ejhp.bmj.com/lookup/doi/10.1136/ejhpharm-2012-000088
Publisher Site
http://dx.doi.org/10.1136/ejhpharm-2012-000088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3591257PMC
October 2012
34 Reads
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